Blar i Department of Biomedicine på tidsskrift "PLOS ONE"
Viser treff 1-9 av 9
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Attention-deficit/hyperactivity disorder and smoking habits in pregnant women
(Journal article; Peer reviewed, 2020)Background Attention-deficit/hyperactivity disorder (ADHD) has been associated with an increased risk of tobacco smoking, and more difficulties with smoking cessation compared to non-ADHD individuals. Women with ADHD may ... -
Biophysical analysis of Plasmodium falciparum Hsp70-Hsp90 organising protein (PfHop) reveals a monomer that is characterised by folded segments connected by flexible linkers
(Journal article; Peer reviewed, 2020)Plasmodium falciparum causes the most lethal form of malaria. The cooperation of heat shock protein (Hsp) 70 and 90 is thought to facilitate folding of select group of cellular proteins that are crucial for cyto-protection ... -
CCT196969 effectively inhibits growth and survival of melanoma brain metastasis cells
(Journal article; Peer reviewed, 2022)Melanomas frequently metastasize to the brain. Despite recent progress in the treatment of melanoma brain metastasis, therapy resistance and relapse of disease remain unsolved challenges. CCT196969 is a SRC family kinase ... -
Conserved intramolecular networks in GDAP1 are closely connected to CMT-linked mutations and protein stability
(Journal article; Peer reviewed, 2023)Charcot-Marie-Tooth disease (CMT) is the most common inherited peripheral polyneuropathy in humans, and its subtypes are linked to mutations in dozens of different genes, including the gene coding for ganglioside-induced ... -
Crystal and solution structures reveal oligomerization of individual capsid homology domains of Drosophila Arc
(Journal article; Peer reviewed, 2021)Synaptic plasticity is vital for brain function and memory formation. One of the key proteins in long-term synaptic plasticity and memory is the activity-regulated cytoskeleton-associated protein (Arc). Mammalian Arc forms ... -
High-affinity anti-Arc nanobodies provide tools for structural and functional studies
(Journal article; Peer reviewed, 2022)Activity-regulated cytoskeleton-associated protein (Arc) is a multidomain protein of retroviral origin with a vital role in the regulation of synaptic plasticity and memory formation in mammals. However, the mechanistic ... -
Metabolic analysis of amino acids and vitamin B6 pathways in lymphoma survivors with cancer related chronic fatigue
(Journal article; Peer reviewed, 2020)Chronic cancer-related fatigue (CF) is a common and distressing condition in a subset of cancer survivors and common also after successful treatment of malignant lymphoma. The etiology and pathogenesis of CF is unknown, ... -
Structural characterization of two nanobodies targeting the ligand-binding pocket of human Arc
(Journal article; Peer reviewed, 2024)The activity-regulated cytoskeleton-associated protein (Arc) is a complex regulator of synaptic plasticity in glutamatergic neurons. Understanding its molecular function is key to elucidate the neurobiology of memory and ... -
Survival in a consecutive series of 467 glioblastoma patients: Association with prognostic factors and treatment at recurrence at two independent institutions
(Journal article; Peer reviewed, 2023-02-02)Therapy of recurrent glioblastoma (GBM) is challenging due to lack of standard treatment. We investigated physicians’ treatment choice at recurrence and prognostic and predictive factors for survival in GBM patients from ...