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dc.contributor.authorKraby, Maria Ryssdalen_US
dc.contributor.authorKrüger, Kristien_US
dc.contributor.authorOpdahl, Signeen_US
dc.contributor.authorVatten, Lars Johanen_US
dc.contributor.authorAkslen, Lars A.en_US
dc.contributor.authorBofin, Anna M.en_US
dc.date.accessioned2019-04-09T12:46:51Z
dc.date.available2019-04-09T12:46:51Z
dc.date.issued2015
dc.PublishedKraby MR, Krüger K, Opdahl S, Vatten LJ, Akslen LA, Bofin A M. Microvascular proliferation in luminal A and basal-like breast cancer subtypes. Journal of Clinical Pathology. 2015;68(11):891-897eng
dc.identifier.issn0021-9746
dc.identifier.issn1472-4146
dc.identifier.urihttps://hdl.handle.net/1956/19304
dc.description.abstractAims: The aims of this study were to examine microvessel density (MVD), proliferating MVD (pMVD) and Vascular Proliferation Index (VPI) in basal-like phenotype (BP) and luminal A subtypes of breast cancer and to study their prognostic value. Methods: Dual-colour immunohistochemistry for von Willebrand factor and Ki67 was done on sections from 62 luminal A and 62 BP tumours matched for grade and selected from 909 breast cancers previously reclassified into molecular subtypes. Associations between MVD, pMVD and VPI, molecular subtypes and breast cancer prognosis were estimated using linear regression and survival analyses. Results: Both pMVD (difference 1.9 microvessels/mm2 (p=0.002)) and VPI (difference 1.7 percentage points (p=0.014)) were higher in BP tumours compared with luminal A. No clear difference between subtypes was found for MVD. However, only MVD was associated with prognosis. HR for breast cancer death for all cases was 1.10 (95% CI 1.02 to 1.18) per 10 vessels increase. Among luminal A tumours, HR was 1.22 per 10 vessels increase (p<0.001) and in BP it was 1.04 (p=0.37). Conclusions: High MVD was associated with poor prognosis in luminal A, but not in BP cancers. Vascular proliferation was higher in BP, indicating a more active angiogenesis than in luminal A tumours. The luminal A subgroup comprised mostly histopathological grade 3 cancers in this selected series, and further studies are needed to clarify whether MVD provides additional prognostic information for luminal A tumours irrespective of grade. This may contribute to stratification of this large group of patients and may aid in identifying tumours with a particularly good prognosis.en_US
dc.language.isoengeng
dc.publisherBMJeng
dc.titleMicrovascular proliferation in luminal Aand basal-like breast cancer subtypesen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2018-12-04T08:50:15Z
dc.description.versionacceptedVersionen_US
dc.rights.holderCopyright 2015 The Author(s)
dc.identifier.doihttps://doi.org/10.1136/jclinpath-2015-203037
dc.identifier.cristin1279339
dc.source.journalJournal of Clinical Pathology
dc.relation.projectNorges forskningsråd: 223250
dc.relation.projectNorges forskningsråd: 191778


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