N-terminal modifications of cellular proteins: the enzymes involved, their substrate specificities and biological effects
dc.contributor.author | Varland, Sylvia | |
dc.contributor.author | Osberg, Camilla | |
dc.contributor.author | Arnesen, Thomas | |
dc.date.accessioned | 2016-01-04T13:07:21Z | |
dc.date.available | 2016-01-04T13:07:21Z | |
dc.date.issued | 2015-06-16 | |
dc.Published | Proteomics 2015 | eng |
dc.identifier.issn | 1615-9861 | en_US |
dc.identifier.uri | https://hdl.handle.net/1956/10857 | |
dc.description.abstract | The vast majority of eukaryotic proteins are N-terminally modified by one or more processing enzymes. Enzymes acting on the very first amino acid of a polypeptide include different peptidases, transferases, and ligases. Methionine aminopeptidases excise the initiator methionine leaving the nascent polypeptide with a newly exposed amino acid that may be further modified. N-terminal acetyl-, methyl-, myristoyl-, and palmitoyltransferases may attach an acetyl, methyl, myristoyl, or palmitoyl group, respectively, to the α-amino group of the target protein N-terminus. With the action of ubiquitin ligases, one or several ubiquitin molecules are transferred, and hence, constitute the N-terminal modification. Modifications at protein N-termini represent an important contribution to proteomic diversity and complexity, and are essential for protein regulation and cellular signaling. Consequently, dysregulation of the N-terminal modifying enzymes is implicated in human diseases. We here review the different protein N-terminal modifications occurring co- or post-translationally with emphasis on the responsible enzymes and their substrate specificities. | en_US |
dc.language.iso | eng | eng |
dc.publisher | Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim | en_US |
dc.relation.uri | http://onlinelibrary.wiley.com/doi/10.1002/pmic.201400619/epdf | |
dc.rights | Attribution CC BY | eng |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0 | eng |
dc.subject | α-amino group | eng |
dc.subject | Acetylation | eng |
dc.subject | N-terminal | eng |
dc.subject | Cell biology | eng |
dc.title | N-terminal modifications of cellular proteins: the enzymes involved, their substrate specificities and biological effects | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2015-12-22T10:30:55Z | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2015 The Authors | en_US |
dc.identifier.doi | https://doi.org/10.1002/pmic.201400619 | |
dc.identifier.cristin | 1242076 | |
dc.subject.nsi | VDP::Medisinske Fag: 700 | en_US |