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    • Fueling the flames of colon cancer – does CRP play a direct pro-inflammatory role? 

      Køstner, Anne Helene; Fuglestad, Anniken Jørlo; Georgsen, Jeanette Baehr; Nielsen, Patricia Switten; Christensen, Kristina Bang; Zibrandtsen, Helle; Parner, Erik Thorlund; Rajab, Ibraheem M.; Potempa, Lawrence A.; Steiniche, Torben; Kersten, Christian (Journal article; Peer reviewed, 2023-03-17)
      Background: Systemic inflammation, diagnostically ascribed by measuring serum levels of the acute phase reactant C-reactive protein (CRP), has consistently been correlated with poor outcomes across cancer types. CRP exists ...

    • Full breastfeeding protection against common enteric bacteria and viruses: Results from the MAL-ED cohort study 

      Mccormick, Benjamin J. J; Richard, Stephanie A; Murray-Kolb, Laura E; Kang, Gagandeep; Lima, Aldo A. M; Mduma, Estomih; Kosek, Margaret N; Rogawski Mcquade, Elizabeth T; Houpt, Eric R; Bessong, Pascal; Shrestha, Sanjaya; Bhutta, Zulfiqar; Ahmed, Tahmeed; Caulfield, Laura E; Acosta, Angel Mendez; De Burga, Rosa Rios; Chavez, Cesar Banda; Flores, Julian Torres; Olotegui, Maribel Paredes; Pinedo, Silvia Rengifo; Salas, Mery Siguas; Trigoso, Dixner Rengifo; Vasquez, Angel Orbe; Ahmed, Imran; Alam, Didar; Ali, Asad; Bhutta, Zulfiqar A.; Qureshi, Shahida; Rasheed, Muneera Abdul; Soofi, Sajid; Turab, Ali; Yousafzai, Aisha; Zaidi, Anita K. M.; Bodhidatta, Ladaporn; Ammu, Geetha; Babji, Sudhir; Bose, Anuradha; George, Ajila T.; Hariraju, Dinesh; Jennifer, M Steffi; John, Sushil; Kaki, Shiny; Karunakaran, Priyadarshani; Koshy, Beena; Lazarus, Robin P.; Muliyil, Jayaprakash; Ragasudha, Preethi; Raghava, Mohan Venkata; Raju, Sophy; Ramachandran, Anup; Ramadas, Rakhi; Ramanujam, Karthikeyan; Rose, Anuradha; Roshan, Reeba; Sharma, Srujan L.; Shanmuga Sundaram, Sundaram; Thomas, Rahul J.; Pan, William K.; Ambikapathi, Ramya; Carreon, J. Daniel; Doan, Viyada; Hoest, Christel; Knobler, Stacey; McCormick, Benjamin J. J.; McGrath, Monica; Miller, Mark A.; Psaki, Stephanie; Rasmussen, Zeba; Seidman, Jessica C.; Gottlieb, Michael; Lang, Dennis R.; Tountas, Karen H.; Svensen, Erling; Amour, Caroline; Bayyo, Eliwaza; Mduma, Estomih R.; Mvungi, Regisiana; Nshama, Rosemary; Pascal, John; Swema, Buliga Mujaga; Yarrot, Ladislaus; Mason, Carl J.; Shamsir Ahmed, Ahmed; Alam, Md Ashraful; Haque, Rashidul; Haque, Umma; Hossain, Md Iqbal; Islam, Munirul; Mahfuz, Mustafa; Mondal, Dinesh; Nahar, Baitun; Tofail, Fahmida; Chandyo, Ram Krishna; Shrestha, Prakash Sunder; Shrestha, Rita; Chandyo, Manjeswori Ulak; Bauck, Aubrey; Black, Robert E.; Checkley, William; Lee, Gwenyth O.; Schulze, Kerry; Yori, Pablo Peñataro; Ross, A. Catharine; Schaefer, Barbara; Simons, Suzanne; Pendergast, Laura; Abreu, Cláudia B.; Costa, Hilda; Di Moura, Alessandra; Filho, José Quirino; Havt, Alexandre; Leite, Álvaro M.; Lima, Noélia L.; Lima, Ila F.; Maciel, Bruna L. L.; Medeiros, Pedro H. Q. S.; Moraes, Milena; Mota, Francisco S.; Oriá, Reinaldo B.; Quetz, Josiane; Soares, Alberto M.; Mota, Rosa M. S.; Patil, Crystal L.; Mahopo, Cloupas; Maphula, Angelina; Nyathi, Emanuel; Samie, Amidou; Barrett, Leah; Dillingham, Rebecca; Gratz, Jean; Guerrant, Richard L.; Houpt, Eric; Petri, William A.; Platts-Mills, James; Rogawski, Elizabeth; Scharf, Rebecca; Rogawski, Elizabeth T.; Shrestha, Binob; Rayamajhi, Bishnu Bahadur; Strand, Tor Arne (Journal article; Peer reviewed, 2022)
      Background Breastfeeding is known to reduce the risk of enteropathogen infections, but protection from specific enteropathogens is not well characterized. Objective The aim was to estimate the association between full ...

    • Full family of flattening solitary waves for the critical generalized KdV equation 

      Martel, Yvan; Pilod, Didier Jacques Francois (Journal article; Peer reviewed, 2020)
      For the critical generalized KdV equation ∂tu+∂x(∂2xu+u5)=0 on R, we construct a full family of flattening solitary wave solutions. Let Q be the unique even positive solution of Q′′+Q5=Q. For any ν∈(0,13), there exist ...

    • A full year of turbulence measurements from a drift campaign in the Arctic Ocean 2019-2020 

      Schulz, K.; Mohrholz, Volker; Fer, Ilker; Janout, Markus; Hoppmann, Mario; Schaffer, Janin; Koenig, Zoe Charlotte (Journal article; Peer reviewed, 2022)
      Ocean turbulent mixing is a key process in the global climate system, regulating ocean circulation and the uptake and redistribution of heat, carbon, nutrients, oxygen and other tracers. In polar oceans, turbulent heat ...

    • Fully Automatic Whole-Volume Tumor Segmentation in Cervical Cancer 

      Hodneland, Erlend; Kaliyugarasan, Sathiesh Kumar; Wagner-Larsen, Kari Strøno; Lura, Njål Gjærde; Andersen, Erling; Bartsch, Hauke; Smit, Noeska Natasja; Halle, Mari Kyllesø; Krakstad, Camilla; Lundervold, Alexander Selvikvåg; Haldorsen, Ingfrid S. (Journal article; Peer reviewed, 2022-05-11)
      Uterine cervical cancer (CC) is the most common gynecologic malignancy worldwide. Whole-volume radiomic profiling from pelvic MRI may yield prognostic markers for tailoring treatment in CC. However, radiomic profiling ...

    • A fully coupled numerical model of thermo-hydro-mechanical processes and fracture contact mechanics in porous media 

      Stefansson, Ivar; Keilegavlen, Eirik; Berre, Inga (Journal article; Peer reviewed, 2021)
      Various phenomena in the subsurface are characterised by the interplay between deforming structures such as fractures and coupled thermal, hydraulic and mechanical processes. Simulation of subsurface dynamics can provide ...

    • A function of profilin in force generation during malaria parasite motility that is independent of actin binding 

      Moreau, Catherine A.; Quadt, Katharina A.; Piirainen, Henni; Kumar, Hirdesh; Bhargav, Saligram P.; Strauss, Léanne; Tolia, Niraj H; Wade, Rebecca C.; Spatz, Joachim P; Kursula, Inari; Frischknecht, Friedrich (Journal article; Peer reviewed, 2020)
      During transmission of malaria-causing parasites from mosquito to mammal, Plasmodium sporozoites migrate at high speed within the skin to access the bloodstream and infect the liver. This unusual gliding motility is based ...

    • Functional activity level reported by an informant is an early predictor of Alzheimer’s disease 

      Vik, Alexandra; Kocinski, Marek Michal; Rye, Ingrid Karlsen; Lundervold, Astri J.; Lundervold, Alexander Selvikvåg (Journal article; Peer reviewed, 2023)
      Background Loss of autonomy in day-to-day functioning is one of the feared outcomes of Alzheimer’s disease (AD), and relatives may have been worried by subtle behavioral changes in ordinary life situations long before these ...

    • Functional Analyses of Rare Germline Missense BRCA1 Variants Located within and outside Protein Domains with Known Functions 

      Hovland, Henrikke Nilsen; Mchaina, Eunice Kabanyana; Vetti, Hildegunn Høberg; Ariansen, Sarah Louise; Sjursen, Wenche; Van Ghelue, Marijke; Haukanes, Bjørn Ivar; Knappskog, Per Morten; Aukrust, Ingvild; Berge, Elisabet Ognedal (Journal article; Peer reviewed, 2023-01-19)
      The BRCA1 protein is implicated in numerous important cellular processes to prevent genomic instability and tumorigenesis, and pathogenic germline variants predispose carriers to hereditary breast and ovarian cancer (HBOC). ...

    • Functional analysis and exterior calculus on mixed-dimensional geometries 

      Boon, Wietse; Nordbotten, Jan Martin; Vatne, Jon Eivind (Journal article; Peer reviewed, 2020-07-12)
      We are interested in differential forms on mixed-dimensional geometries, in the sense of a domain containing sets of d-dimensional manifolds, structured hierarchically so that each d-dimensional manifold is contained in ...

    • Functional and Binding H1N1pdm09-Specific Antibody Responses in Occasionally and Repeatedly Vaccinated Healthcare Workers: A Five-Year Study (2009-2014) 

      Amdam, Håkon; Madsen, Anders; Zhou, Fan; Bansal, Amit; Trieu, Mai Chi; Cox, Rebecca Jane (Journal article; Peer reviewed, 2021)
      Background: In 2009, a novel influenza A/H1N1pdm09 emerged and caused a pandemic. This strain continued to circulate and was therefore included in the seasonal vaccines up to the 2016/2017-season. This provided a unique ...

    • Functional annotation of human long noncoding RNAs via molecular phenotyping 

      Ramilowski, Jordan; Yip, Chiu Wai Mickey; Agrawal, Saumya; Chang, Jen-Chien; Ciani, Yari; Kulakovskiy, Ivan; Mendez, Mickaël; Ching Ooi, Jasmine Li; Ouyang, John F; Parkinson, Nick; Kasukawa, Takeya; Kauppinen, Sakari; Kere, Juha; Lenhard, Boris; Schneider, Claudio; Suzuki, Harukazu; Yagi, Ken; De Hoon, Michiel J L; Shin, Jay W; Piero, Carninci (Journal article; Peer reviewed, 2020)
      Long noncoding RNAs (lncRNAs) constitute the majority of transcripts in the mammalian genomes, and yet, their functions remain largely unknown. As part of the FANTOM6 project, we systematically knocked down the expression ...

    • Functional brain networks in the schizophrenia spectrum and bipolar disorder with psychosis 

      van Dellen, Edwin; Börner, Corinna; Schutte, Maya; van Montfort, Simone; Abramovic, Lucija; Boks, Marco P.; Cahn, Wiepke; van Haren, Neeltje E.M.; Mandl, René; Stam, Cornelis J.; Sommer, Iris Else Clara (Journal article; Peer reviewed, 2020)
      Psychotic experiences have been proposed to lie on a spectrum, ranging from subclinical experiences to treatment-resistant schizophrenia. We aimed to characterize functional connectivity and brain network characteristics ...

    • Functional characterization of all-trans retinoic acid-induced differentiation factor (ATRAID) 

      Mehrasa, Roya; Cristea, Ileana; Bredrup, Cecilie; Rødahl, Eyvind; Bruland, Ove (Journal article; Peer reviewed, 2023)
      All-trans retinoic acid-induced differentiation (ATRAID) factor was first identified in HL60 cells. Several mRNA isoforms exist, but the respective proteins have not been fully characterized. In transfected cells expressing ...

    • Functional characterization of Atlantic salmon (Salmo salar L.) PepT2 transporters 

      Vacca, Francesca; Gomes, Ana S.; Murashita, Koji; Cinquetti, Raffella; Roseti, Cristina; Barca, Amilcare; Rønnestad, Ivar; Verri, Tiziano; Bossi, Elena (Journal article; Peer reviewed, 2022)
      The high-affinity/low-capacity system Slc15a2 (PepT2) is responsible for the reuptake of di/tripeptides from the renal proximal tubule, but it also operates in many other tissues and organs. Information regarding PepT2 in ...

    • Functional connectome differences in individuals with hallucinations across the psychosis continuum 

      Schutte, Maya J. L.; Bohlken, Marc M.; Collin, Guusje; Abramovic, Lucija; Boks, Marco P. M.; Cahn, Wiepke; Dauwan, Meenakshi; van Dellen, Edwin; van Haren, Neeltje E. M.; Hugdahl, Kenneth; Koops, Sanne; Mandl, René C. W.; Sommer, Iris E. C. (Journal article; Peer reviewed, 2021)
      Hallucinations may arise from an imbalance between sensory and higher cognitive brain regions, reflected by alterations in functional connectivity. It is unknown whether hallucinations across the psychosis continuum exhibit ...

    • Functional Data Analysis of Non-manual Marking of Questions in Kazakh-Russian Sign Language 

      Kuznetsova, Anna; Imashev, Alfarabi; Mukushev, Medet; Sandygulova, Anara; Kimmelman, Vadim (Chapter, 2022)
      This paper is a continuation of Kuznetsova et al. (2021), which described non-manual markers of polar and wh-questions in comparison with statements in an NLP dataset of Kazakh-Russian Sign Language (KRSL) using Computer ...

    • Functional evaluation of 16 SCHAD missense variants: Only amino acid substitutions causing congenital hyperinsulinism of infancy lead to loss-of-function phenotypes in vitro 

      Velasco Pinto, Kelly; St-Louis, Johanna; Hovland, Henrikke N.; Thompson, Nels; Ottesen, Åsta; Choi, Man Hung; Pedersen, Line; Njølstad, Pål Rasmus; Arnesen, Thomas; Fjeld, Karianne; Aukrust, Ingvild; Myklebust, Line Merethe; Molven, Anders (Journal article; Peer reviewed, 2021)
      Short‐chain 3‐hydroxyacyl‐CoA dehydrogenase (SCHAD), encoded by the HADH gene, is a ubiquitously expressed mitochondrial enzyme involved in fatty acid oxidation. This protein also plays a role in insulin secretion as ...

    • Functional Evolution of Clustered Aquaporin Genes Reveals Insights into the Oceanic Success of Teleost Eggs 

      Ferré, Alba; Chauvigné, Francois; Vlasova, Anna; Norberg, Birgitta; Bargelloni, Luca; Guigó, Roderic; Finn, Roderick Nigel; Cerdà, Joan (Journal article; Peer reviewed, 2023)
      Aquaporin-mediated oocyte hydration is considered important for the evolution of pelagic eggs and the radiative success of marine teleosts. However, the molecular regulatory mechanisms controlling this vital process are ...

    • Functional inequalities on path space of sub-Riemannian manifolds and applications 

      Cheng, Li-Juan; Grong, Erlend; Thalmaier, Anton (Journal article; Peer reviewed, 2021)
      We consider the path space of a manifold with a measure induced by a stochastic flow with an infinitesimal generator that is hypoelliptic, but not elliptic. These generators can be seen as sub-Laplacians of a sub-Riemannian ...