Blar i Department of Clinical Science på tittel
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Identification of inhibitors of tryptophan hydroxylase 1
(Master thesis, 2014-05-20)Background: In this study we use molecular docking to find compounds that interact with the enzyme tryptophan hydroxylase (TPH), followed by experimental validation. TPH is a tetrahydrobiopterin (BH4) dependent enzyme that ... -
Identification of microRNAs from medicinal plant Murraya Koenigii by high-throughput sequencing and their functional implications in secondary metabolite biosynthesis
(Journal article; Peer reviewed, 2022)MicroRNAs (miRNAs) are small noncoding RNA molecules that play crucial post-transcriptional regulatory roles in plants, including development and stress-response signaling. However, information about their involvement in ... -
Identification of nine new susceptibility loci for endometrial cancer
(Peer reviewed; Journal article, 2018-08-09)Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial ... -
Identification of novel monocistronic HTLV-1 mRNAs encoding functional Rex isoforms
(Peer reviewed; Journal article, 2015-07-02)Background: Human T cell leukemia virus type 1 (HTLV-1) gene expression is controlled by the key regulatory proteins Tax and Rex. The concerted action of these proteins results in a two-phase kinetics of viral expression ... -
Identification of pharmacological chaperones for Phenylalanine Hydroxylase. A virtual screening approach to discover novel drug candidates for treatment of phenylketonuria
(Master thesis, 2014-05-20)Phenylalanine hydroxylase (PAH) is an enzyme that catalyses the hydroxylation of phenylalanine into tyrosine in the liver, which is the rate-limiting step in phenylalanine catabolism. PAH is a non-heme iron-dependent enzyme ... -
Identification of pleiotropy at the gene level between psychiatric disorders and related traits
(Journal article; Peer reviewed, 2021)Major mental disorders are highly prevalent and make a substantial contribution to the global disease burden. It is known that mental disorders share clinical characteristics, and genome-wide association studies (GWASs) ... -
Identification of shared genetic variants between schizophrenia and lung cancer
(Peer reviewed; Journal article, 2018-01-12)Epidemiology studies suggest associations between schizophrenia and cancer. However, the underlying genetic mechanisms are not well understood, and difficult to identify from epidemiological data. We investigated if there ... -
Identification of subclinical tuberculosis in household contacts using exposure scores and contact investigations
(Journal article; Peer reviewed, 2020-01-31)Background: The goal of tuberculosis elimination put forward in the End TB Strategy prioritizes diagnosis and treatment of incipient and subclinical TB, recently defined by key stakeholders as “asymptomatic, early pre-clinical ... -
Identification of susceptibility pathways for the roleof chromosome 15q25.1 in modifying lung cancerrisk
(Peer reviewed; Journal article, 2018-08-13)Genome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, the pathogenic pathways, through which susceptibility SNPs within chromosome 15q25.1 ... -
Identification of the functional role of GSK3β in the ex vivo female rat heart at ischemic reperfusion--with special reference to Akt-dependent signalling
(Master thesis, 2009-05-14)Coronary heart disease is the leading cause of death worldwide, arising mainly from ischemic heart disease. Currently, the most effective method for reducing mortality in patients suffering from a coronary occlusion is ... -
Identifikasjon av fettsyrer i omega-3 produkter ved hjelp av gasskromatografi med massespektrometrisk deteksjon
(Master thesis, 2012-08-24)The purpose of this study was to identify fatty acids in omega-3 products that are sold in the market in different countries and build databases of mass spectra and chromatographic retention indices. These databases can ... -
Identifying nootropic drug targets via large-scale cognitive GWAS and transcriptomics
(Journal article; Peer reviewed, 2021)Broad-based cognitive deficits are an enduring and disabling symptom for many patients with severe mental illness, and these impairments are inadequately addressed by current medications. While novel drug targets for ... -
Identifying target areas of medicines information efforts to pregnant and breastfeeding women by reviewing questions to SafeMotherMedicine: A Norwegian web-based public medicines information service
(Journal article; Peer reviewed, 2022)Background Online information about safety of medications during pregnancy and breastfeeding is shown to be conflicting, resulting in anxiety and abstaining from use. The aim of this study was to characterize questions ... -
Identifying targets for antibiotic stewardship interventions through analysis of the antibiotic prescribing process in hospitals - a multicentre observational cohort study
(Journal article; Peer reviewed, 2020)Background: In order to change antibiotic prescribing behaviour, we need to understand the prescribing process. The aim of this study was to identify targets for antibiotic stewardship interventions in hospitals through ... -
IFN-α with dasatinib broadens the immune repertoire in patients with chronic-phase chronic myeloid leukemia
(Journal article; Peer reviewed, 2022)In chronic myeloid leukemia (CML), combination therapies with tyrosine kinase inhibitors (TKIs) aim to improve the achievement of deep molecular remission that would allow therapy discontinuation. IFN-α is one promising ... -
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(Journal article, 2022) -
IL-18 and IL-18 binding protein are related to disease severity and parasitemia during falciparum malaria
(Journal article; Peer reviewed, 2021)Background: Several inflammatory molecules participate in the immune response to malaria. Interleukin (IL)-18 is an inflammatory cytokine activated by NLRP3 inflammasomes. In clinical falciparum malaria, with and without ... -
IL-6 Responsiveness of CD4+ and CD8+ T Cells after Allogeneic Stem Cell Transplantation Differs between Patients and Is Associated with Previous Acute Graft versus Host Disease and Pretransplant Antithymocyte Globulin Therapy
(Journal article; Peer reviewed, 2022)Graft-versus-host disease (GVHD), one of the most common and serious complications after allogeneic stem cell transplantation, is mediated by allocative T cells. IL-6 mediates both pro- and anti-inflammatory effects and ... -
ILD-specific health-related quality of life in systemic sclerosis-associated ILD compared with IPF
(Journal article; Peer reviewed, 2020)Abstract Introduction Idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-associated interstitial lung disease (SSc-ILD) are fibrotic ILDs with divergent disease populations. Little is known about health-related ...