Browsing Department of Clinical Science by Title
Now showing items 1254-1273 of 2310
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The kynurenine pathway in cognition, dementia, and aging
(Doctoral thesis, 2021-06-16)Background: Experimental studies implicate the kynurenine pathway in cognitive function, dementia, aging, and longevity. Comparatively, clinical studies are few and most lack comprehensive targeted metabolomic profiling ... -
The Kynurenine Pathway Is Upregulated by Methyl-deficient Diet and Changes Are Averted by Probiotics
(Journal article; Peer reviewed, 2021)Scope Probiotics exert immunomodulatory effects and may influence tryptophan metabolism in the host. Deficiency of nutrients related to C1 metabolism might stimulate inflammation by enhancing the kynurenine pathway. This ... -
Kynurenine Pathway Metabolites in the Blood and Cerebrospinal Fluid Are Associated with Human Aging
(Journal article; Peer reviewed, 2022)The kynurenine pathway is implicated in aging, longevity, and immune regulation, but longitudinal studies and assessment of the cerebrospinal fluid (CSF) are lacking. We investigated tryptophan (Trp) and downstream kynurenine ... -
Kynurenines, Neuropsychiatric Symptoms, and Cognitive Prognosis in Patients with Mild Dementia
(Journal article; Peer reviewed, 2019)Introduction: Circulating tryptophan (Trp) and its downstream metabolites, the kynurenines, are potentially neuroactive. Consequently, they could be associated with neuropsychiatric symptoms and cognitive prognosis in ... -
Label-free quantitative proteomic analysis of the oral bacteria Fusobacterium nucleatum and Porphyromonas gingivalis to identify protein features relevant in biofilm formation
(Journal article; Peer reviewed, 2021)Background The opportunistic pathogens Fusobacterium nucleatum and Porphyromonas gingivalis are Gram-negative bacteria associated with oral biofilm and periodontal disease. This study investigated interactions between F. ... -
Laboratory contamination in airway microbiome studies
(Peer reviewed; Journal article, 2019-08-14)Background The low bacterial load in samples acquired from the lungs, have made studies on the airway microbiome vulnerable to contamination from bacterial DNA introduced during sampling and laboratory processing. We have ... -
Laparoskopisk gastrisk bypassoperasjon versus livsstilsbehandling av unge med sykelig overvekt
(Journal article; Peer reviewed, 2020)BAKGRUNN Kunnskapsgrunnlaget om effekten av og komplikasjoner ved vektreduserende kirurgi hos ungdom er mangelfullt. Hovedformålet med 4XL-studien er å avklare om laparoskopisk Roux-en-Y gastrisk bypassoperasjon (LGBP) ... -
A large community outbreak of waterborne giardiasis- delayed detection in a non-endemic urban area
(BMC Public Health 6(141), Peer reviewed; Journal article, 2006-05-25)Background: Giardia is not endemic in Norway, and more than 90% of reported cases acquire the infection abroad. In late October 2004, an increase in laboratory confirmed cases of giardiasis was reported in the city of ... -
Large-scale genomics unveil polygenic architecture of human cortical surface area
(Peer reviewed; Journal article, 2015-07-20)Little is known about how genetic variation contributes to neuroanatomical variability, and whether particular genomic regions comprising genes or evolutionarily conserved elements are enriched for effects that influence ... -
Laryngeal response patterns during mechanically assisted cough in Amyotrophic Lateral Sclerosis
(Doctoral thesis, 2018-06-21)Background: Patients with amyotrophic lateral sclerosis (ALS) are treated with mechanical cough assist devices using the technique of mechanical insufflationexsufflation (MI-E) in order to improve cough and enhance clearance ... -
Laryngeal tube use in out-of-hospital cardiac arrest by paramedics in Norway
(Peer reviewed; Journal article, 2012-12-18)Background: Although there are numerous supraglottic airway alternatives to endotracheal intubation, it remains unclear which airway technique is optimal for use in prehospital cardiac arrests. We evaluated the use of the ... -
Late-onset sepsis in very preterm infants in Norway in 2009-2018: A population-based study
(Journal article; Peer reviewed, 2023)Objective: To evaluate epidemiology and outcomes among very preterm infants (<32 weeks’ gestation) with culture-positive and culture-negative late-onset sepsis (LOS). Design: Cohort study using a nationwide, population-based ... -
Late-week surgical treatment of endometrial cancer is associated with worse long-term outcome: Results from a prospective, multicenter study
(Peer reviewed; Journal article, 2017-08-03)Surgery is the cornerstone in primary endometrial cancer treatment, and with curative intent it constitutes total hysterectomy and bilateral salpingo-oopherectomy. In addition, lymphadenectomy is performed in selected ... -
Latencies longer than 3.5 ms after vagus nerve stimulation does not exclude a nonrecurrent inferior laryngeal nerve
(Peer reviewed; Journal article, 2014-08-28)Background: It has recently been reported that a signal latency shorter than 3.5 ms after electrical stimulation of the vagus nerve signify a nonrecurrent course of the inferior laryngeal nerve. We present a patient with ... -
Latitude, Birth Date, and Allergy
(PLoS Medicine 2(10): e294, Peer reviewed; Journal article, 2005-10-04)Background: The space and time distribution of risk factors for allergic diseases may provide insights into disease mechanisms. Allergy is believed to vary by month of birth, but multinational studies taking into account ... -
Learning from experience: a qualitative study of surgeons’ perspectives on reporting and dealing with serious adverse events
(Journal article; Peer reviewed, 2023)Introduction In surgery, serious adverse events have effects on the patient journey, the patient outcome and may constitute a burden to the surgeon involved. This study aims to investigate facilitators and barriers to ... -
Left ventricular dysfunction after two hours of polarizing or depolarizing cardioplegic arrest in a porcine model
(Peer reviewed; Journal article, 2019)Introduction: This experimental study compares myocardial function after prolonged arrest by St. Thomas’ Hospital polarizing cardioplegic solution (esmolol, adenosine, Mg2+) with depolarizing (hyperkalaemic) St. Thomas’ ... -
Left ventricular hypertrophy contributes to Myocardial Ischemia in Non-obstructive Coronary Artery Disease (the MicroCAD study)
(Peer reviewed; Journal article, 2019)Background: The underlying mechanisms causing myocardial ischemia in non-obstructive coronary artery disease (CAD) are still unclear. We explored whether left ventricular hypertrophy (LVH) was associated with myocardial ... -
A left ventricular phantom for 3D echocardiographic twist measurements
(Peer reviewed; Journal article, 2020)Traditional two-dimensional (2D) ultrasound speckle tracking echocardiography (STE) studies have shown a wide range of twist values, also for normal hearts, which is due to the limitations of short-axis 2D ultrasound. The ... -
Left ventricular venting during extracorporeal membrane oxygenation; the effects on cardiac performance in a porcine model of critical post-cardiotomy failure
(Journal article; Peer reviewed, 2022)Introduction Left ventricular distension is a major concern with postcardiotomy veno-arterial extracorporeal membrane oxygenation (VA-ECMO) supporting a critical heart failure after cardiac surgery. This porcine study ...