Browsing Department of Clinical Science by Title

Now showing items 1794-1813 of 2310

    • Prolonged and persistent diarrhoea is not restricted to children with acute malnutrition: an observational study in Ethiopia 

      Zangenberg, Mike; Johansen, Øystein Haarklau; Abdissa, Alemseged; Eshetu, Beza; Kurtzhals, Jørgen Anders; Friis, Henrik; Sommerfelt, Halvor; Langeland, Nina; Hanevik, Kurt (Peer reviewed; Journal article, 2019)
      Objectives: To assess the prevalence of prolonged and persistent diarrhoea, to estimate their co‐occurrence with acute malnutrition and association with demographic and clinical factors. Methods: Case–control study where ...

    • Prolonging the delivery of influenza virus vaccine improves the quantity and quality of the induced immune responses in mice 

      Beukema, Martin; Gong, Shuran; Al-Jaawni, Kasem; de Vries-Idema, Jacqueline J.; Krammer, Florian; Zhou, Fan; Cox, Rebecca Jane; Huckriede, Anke (Journal article; Peer reviewed, 2023)
      Introduction: Influenza vaccines play a vital role in protecting individuals from influenza virus infection and severe illness. However, current influenza vaccines have suboptimal efficacy, which is further reduced in cases ...

    • A proposed method to investigate reliability throughout a questionnaire 

      Wentzel-Larsen, Tore; Norekvål, Tone M.; Ulvik, Bjørg; Nygård, Ottar; Pripp, Are Hugo (Peer reviewed; Journal article, 2011-10-05)
      Background: Questionnaires are used extensively in medical and health care research and depend on validity and reliability. However, participants may differ in interest and awareness throughout long questionnaires, which ...

    • A prospective observational study on newborn resuscitation in a high-resource setting 

      Bjorland, Peder Aleksander (Doctoral thesis, 2022-10-28)
      Bakgrunn: Omkring åtte prosent av verdens nyfødte har behov for pustehjelp for å klare overgangen fra intra- til ekstrauterint liv. Nøyaktig forekomst er usikker og varierer antagelig mellom ulike settinger, men resuscitering ...

    • A prospective study of pulmonary outcomes and chest computed tomography in the first year after COVID-19 

      Lerum, Tøri Vigeland; Meltzer, Carin; Rivero, Jezabel Rodriguez; Aaløkken, Trond Mogens; Brønstad, Eivind; Aarli, Bernt Bøgvald; Lund, Kristine Marie Aarberg; Durheim, Michael Thomas; Ashraf, Haseem; Einvik, Gunnar; Skjønsberg, Ole Henning; Stavem, Knut (Journal article; Peer reviewed, 2023)
      COVID-19 primarily affects the respiratory system. We aimed to evaluate how pulmonary outcomes develop after COVID-19 by assessing participants from the first pandemic wave prospectively 3 and 12 months following hospital ...

    • A prospective, active haemovigilance study with combined cohort analysis of 19 175 transfusions of platelet components prepared with amotosalen-UVA photochemical treatment 

      Knutson, Folkre; Osselaer, Jean Claude; Pierelli, Luca; Lozano, Miguel; Cid, Joan Rodríguez; Tardivel, René H.; Garraud, Olivier; Hervig, Tor; Domanović, Dragoslav; Cukjati, Marko; Gudmundsson, Sveinn; Hjálmarsdóttir, Ína B.; Castrillo, Azucena; González, Rocío; Brihante, Dialina; Santos, Marlene; Schlenke, Peter; Elliott, Anne; Lin, Jin-Sying; Tappe, David; Stassinopoulos, Adonis; Green, Jennifer M.; Corash, Larry (Peer reviewed; Journal article, 2015-05-15)
      Background and Objectives: A photochemical treatment process (PCT) utilizing amotosalen and UVA light (INTERCEPT™ Blood System) has been developed for inactivation of viruses, bacteria, parasites and leucocytes that can ...

    • Prospects and challenges in the development of universal influenza vaccines 

      Madsen, Anders; Brokstad, Rebecca Jane Cox (Journal article; Peer reviewed, 2020-07-06)
      Current influenza vaccines offer suboptimal protection and depend on annual reformulation and yearly administration. Vaccine technology has rapidly advanced during the last decade, facilitating development of next-generation ...

    • Proteasome‐mediated regulation of GATA2 expression and androgen receptor transcription in benign prostate epithelial cells 

      Azeem, Waqas; Olsen, Jan Roger; Hellem, Margrete Reime; Hua, Yaping; Marvyin, Kristo; Ke, Xisong; Øyan, Anne Margrete; Kalland, Karl Henning (Journal article; Peer reviewed, 2022)
      GATA2 has been shown to be an important transcription factor together with androgen receptor (AR) in prostate cancer cells. Less is known about GATA2 in benign prostate epithelial cells. We have investigated if GATA2 ...

    • Protected sampling is preferable in bronchoscopic studies of the airway microbiome 

      Grønseth, Rune; Drengenes, Christine; Wiker, Harald G; Tangedal, Solveig; Xue, Yaxin; Husebø, Gunnar; Svanes, Øistein; Lehmann, Sverre; Aardal, Marit Elisabeth; Hoang, Tuyen; Kalananthan, Tharmini; Martinsen, Einar Marius Hjellestad; Leiten, Elise Orvedal; Aanerud, Marianne; Nordeide, Eli; Haaland, Ingvild; Jonassen, Inge; Bakke, Per S.; Eagan, Tomas Mikal (Journal article; Peer reviewed, 2017)
      The aim was to evaluate susceptibility of oropharyngeal contamination with various bronchoscopic sampling techniques. 67 patients with obstructive lung disease and 58 control subjects underwent bronchoscopy with ...

    • A protein extract from chicken reduces plasma homocysteine in rats 

      Lysne, Vegard; Bjørndal, Bodil; Vik, Rita; Nordrehaug, Jan Erik; Skorve, Jon; Nygård, Ottar; Berge, Rolf Kristian (Peer reviewed; Journal article, 2015-06-04)
      The present study aimed to evaluate effects of a water-soluble protein fraction of chicken (CP), with a low methionine/glycine ratio, on plasma homocysteine and metabolites related to homocysteine metabolism. Male Wistar ...

    • Protein Post-Translational Modification Crosstalk in Acute Myeloid Leukemia Calls for Action 

      Hernandez-Valladares, Maria; Wangen, Rebecca; Berven, Frode; Guldbrandsen, Astrid (Peer reviewed; Journal article, 2019)
      Background: Post-translational modification (PTM) crosstalk is a young research field. However, there is now evidence of the extraordinary characterization of the different proteoforms and their interactions in a biological ...

    • Protein profiling reveals inter-individual protein homogeneity of arachnoid cyst fluid and high qualitative similarity to cerebrospinal fluid 

      Berle, Magnus; Kroksveen, Ann Cathrine; Haaland, Øystein; Aye, Thin T.; Opsahl, Jill Anette; Oveland, Eystein; Wester, Knut; Ulvik, Rune Johan; Helland, Christian Andre; Berven, Frode S. (Peer reviewed; Journal article, 2011-05-20)
      Background: The mechanisms behind formation and filling of intracranial arachnoid cysts (AC) are poorly understood. The aim of this study was to evaluate AC fluid by proteomics to gain further knowledge about ACs. Two goals ...

    • Proteogenomic Analysis of Polymorphisms and Gene Annotation Divergences in Prokaryotes using a Clustered Mass Spectrometry-Friendly Database 

      De Souza, Gustavo A.; Arntzen, Magnus Øverlie; Fortuin, Suereta; Schürch, Anita; Målen, Hiwa; McEvoy, Christopher R.; Van Soolingen, Dick; Thiede, Bernd; Warren, Robin M.; Wiker, Harald G. (Peer reviewed; Journal article, 2011-01)
      Precise annotation of genes or open reading frames is still a difficult task that results in divergence even for data generated from the same genomic sequence. This has an impact in further proteomic studies, and also ...

    • Proteogenomics in Microbiology: Taking the Right Turn at the Junction of Genomics and Proteomics 

      Kucharova, Veronika; Wiker, Harald G. (Peer reviewed; Journal article, 2014-12)
      High-accuracy and high-throughput proteomic methods have completely changed the way we can identify and characterize proteins. MS-based proteomics can now provide a unique supplement to genomic data and add a new level of ...

    • Proteome and Phosphoproteome Changes Associated with Prognosis in Acute Myeloid Leukemia 

      Aasebø, Elise; Berven, Frode; Bartaula-Brevik, Sushma; Stokowy, Tomasz; Hovland, Randi; Vaudel, Marc; Døskeland, Stein Ove; Mc Cormack, Emmet; Batth, Tanveer S; Olsen, Jesper V; Bruserud, Øystein; Selheim, Frode; Hernandez-Valladares, Maria (Journal article; Peer reviewed, 2020)
      Acute myeloid leukemia (AML) is a hematological cancer that mainly affects the elderly. Although complete remission (CR) is achieved for the majority of the patients after induction and consolidation therapies, nearly ...

    • Proteomic Analysis of Zebrafish Protein Recoding via mRNA Editing by ADAR Enzymes 

      Nasaev, Shamsudin S.; Kopeykina, Anna S.; Kuznetsova, Ksenia; Levitsky, Lev I.; Moshkovskii, Sergei A. (Journal article; Peer reviewed, 2022)
      RNA editing by adenosine deaminases of the ADAR family can lead to protein recoding, since inosine formed from adenosine in mRNA is complementary to cytosine; the resulting codon editing might introduce amino acid substitutions ...

    • Proteomic Comparison of Bone Marrow Derived Osteoblasts and Mesenchymal Stem Cells 

      Aasebø, Elise; Brenner, Annette; Hernandez-Valladares, Maria; Birkeland, Even; Berven, Frode Steingrimsen; Selheim, Frode; Bruserud, Øystein (Journal article; Peer reviewed, 2021)
      Mesenchymal stem cells (MSCs) can differentiate into osteoblasts, and therapeutic targeting of these cells is considered both for malignant and non-malignant diseases. We analyzed global proteomic profiles for osteoblasts ...

    • Proteomic Profiling of Primary Human Acute Myeloid Leukemia Cells Does Not Reflect Their Constitutive Release of Soluble Mediators 

      Aasebø, Elise; Hernandez-Valladares, Maria; Selheim, Frode; Berven, Frode; Brenner, Annette; Bruserud, Øystein (Peer reviewed; Journal article, 2018-12-20)
      Acute myeloid leukemia (AML) is a heterogeneous disease, and communication between leukemic cells and their neighboring leukemia-supporting normal cells is involved in leukemogenesis. The bone marrow cytokine network is ...

    • Proteomic Studies of Primary Acute Myeloid Leukemia Cells Derived from Patients Before and during Disease-Stabilizing Treatment Based on All-Trans Retinoic Acid and Valproic Acid 

      Hernandez-Valladares, Maria; Wangen, Rebecca; Aasebø, Elise; Reikvam, Håkon; Berven, Frode Steingrimsen; Selheim, Frode; Bruserud, Øystein (Journal article; Peer reviewed, 2021)
      All-trans retinoic acid (ATRA) and valproic acid (VP) have been tried in the treatment of non-promyelocytic variants of acute myeloid leukemia (AML). Non-randomized studies suggest that the two drugs can stabilize AML and ...

    • A proteomics sample metadata representation for multiomics integration and big data analysis 

      Dai, Chengxin; Füllgrabe, Anja; Pfeuffer, Julianus; Solovyeva, Elizaveta M.; Deng, Jingwen; Moreno, Pablo; Kamatchinathan, Selvakumar; Kundu, Deepti Jaiswal; George, Nancy; Fexova, Silvie; Grüning, Björn A.; Föll, Melanie Christine; Griss, Johannes; Vaudel, Marc; Audain, Enrique; Locard-Paulet, Marie; Turewicz, Michael; Eisenacher, Martin; Uszkoreit, Julian; Van Den Bossche, Tim; Schwämmle, Veit; Webel, Henry; Schulze, Stefan; Bouyssié, David; Jayaram, Savita; Duggineni, Vinay Kumar; Samaras, Patroklos; Wilhelm, Mathias; Choi, Meena; Wang, Mingxun; Kohlbacher, Oliver; Brazma, Alvis; Papatheodorou, Irene; Bandeira, Nuno; Deutsch, Eric W.; Vizcaíno, Juan Antonio; Bai, Mingze; Sachsenberg, Timo; Levitsky, Lev I.; Perez-Riverol, Yasset (Journal article; Peer reviewed, 2021)
      The amount of public proteomics data is rapidly increasing but there is no standardized format to describe the sample metadata and their relationship with the dataset files in a way that fully supports their understanding ...