Browsing Department of Clinical Science by Title

Now showing items 1927-1946 of 2310

    • Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples 

      Bailey, Matthew H.; Meyerson, William U.; Dursi, L. Jonathan; Wang, Liang-Bo; Dong, Guanlan; Liang, Wen-Wei; Weerasinghe, Amila; Li, Shantao; Li, Yize; Kelso, Sean; Aure, Miriam Ragle; Børresen-Dale, Anne-Lise; Langerød, Anita; Baumhoer, Daniel; Bjerkehagen, Bodil; Garred, Øystein; Lingjærde, Ole Christian; Sauer, Torill; Zaikova, Olga; Myklebost, Ola; Knappskog, Stian; Vazquez, Miguel; Akbani, Rehan; Anur, Pavana; Buchanan, Alex; Chiotti, Kami; Covington, Kyle; Creason, Allison; Niu, Beifang; Bieg, Matthias; Boutros, Paul C.; Buchhalter, Ivo; Butler, Adam P.; Chen, Ken; Chong, Zechen; Drechsel, Oliver; Aaltonen, Lauri; Abascal, Federico; Abeshouse, Adam; Aburatani, H; Adams, David J.; Van Loo, Peter; Saksena, Gordon; Ellrott, Kyle; Wendl, Michael C.; Wheeler, David A.; Getz, Gad; Simpson, Jared T.; Gerstein, Mark B.; Ding, Li (Journal article; Peer reviewed, 2020)
      The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part ...

    • Return to work after coronary artery bypass grafting and aortic valve replacement surgery: A scoping review 

      Mortensen, Michael André Helnes; Sandvik, Reidun Karin Norheim Myhre; Svendsen, Øyvind Sverre; Haaverstad, Rune; Moi, Asgjerd Litlere (Journal article; Peer reviewed, 2021)
      Background Coronary artery bypass grafting surgery and aortic valve replacement surgery are essential treatment options for people suffering from angina pectoris or aortic valve disease. Surgery aims to prolong life ...

    • Revealing missing human protein isoforms based on Ab initio prediction, RNA-seq and proteomics 

      Hu, Zhiqiang; Scott, Hamish S.; Qin, Guangrong; Zheng, Guangyong; Chu, Xixia; Xie, Lu; Adelson, David L.; Oftedal, Bergithe Eikeland; Venugopal, Parvathy; Babic, Milena; Hahn, Christopher N.; Zhang, Bing; Wang, Xiaojing; Li, Nan; Wei, Chaochun (Peer reviewed; Journal article, 2015-07-09)
      Biological and biomedical research relies on comprehensive understanding of protein-coding transcripts. However, the total number of human proteins is still unknown due to the prevalence of alternative splicing. In this ...

    • Review of Clinical Questions Submitted to Norwegian Drug Information Centres Concerning Administration and Dosage to Older Patients of Relevance to Patient-Centric Care 

      Schjøtt, Jan; Andreassen, Lillan Mo; Dale, Gro Helen; Stokes, Charlotte L. (Journal article; Peer reviewed, 2021)
      Patient-centric care entails optimising healthcare provision to patients based on their perspective and opinion. It involves appropriate treatment at a reasonable cost and a focus on patient characteristics in the ...

    • Revisiting the prognostic role of FLT3 mutations in acute myelogenous leukemia 

      Reikvam, Håkon (Journal article; Peer reviewed, 2023)
      Introduction: Approximately one-third of patients with acute myelogenous leukemia (AML) harbor mutations in the fms-like tyrosine kinase 3 (FLT3) gene. The features regarding prognostic impact of FLT3 mutated AML have been ...

    • The Rho GTPase RND3 regulates adipocyte lipolysis 

      Dankel, Simon N; Røst, Therese Halvorsen; Kulyté, Agné; Fandalyuk, Zinayida; Skurk, Thomas; Hauner, Hans; Sagen, Jørn V.; Rydén, Mikael; Arner, Peter; Mellgren, Gunnar (Peer reviewed; Journal article, 2019)
      Background: Adipose tissue plays a crucial role in diet- and obesity-related insulin resistance, with implications for several metabolic diseases. Identification of novel target genes and mechanisms that regulate adipocyte ...

    • Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency 

      Jørgensen, Silje Fjellgård; Macpherson, Magnhild Eide; Bjørnetrø, Tonje; Holm, Kristian; Kummen, Martin; Rashidi, Azita; Michelsen, Annika; Lekva, Tove; Halvorsen, Bente; Trøseid, Marius; Mollnes, Tom Eirik; Berge, Rolf Kristian; Yndestad, Arne; Ueland, Thor; Karlsen, Tom Hemming; Aukrust, Pål; Hov, Johannes Espolin Roksund; Fevang, Børre (Peer reviewed; Journal article, 2019-01-17)
      Common variable immunodefciency (CVID) patients have reduced gut microbial diversity compared to healthy controls. The reduced diversity is associated with gut leakage, increased systemic infammation and ten “key” bacteria ...

    • Rifaximin or Saccharomyces boulardii in heart failure with reduced ejection fraction: Results from the randomized GutHeart trial 

      Awoyemi, Ayodeji Olawale; Mayerhofer, Cristiane; Felix, Alex S.; Hov, Johannes Espolin Roksund; Moscavitch, Samuel D.; Lappegård, Knut Tore; Hovland, Anders; Halvorsen, Sigrun; Halvorsen, Bente; Gregersen, Ida; Svardal, Asbjørn M.; Berge, Rolf Kristian; Hansen, Simen Hyll; Götz, Alexandra; Holm, Kristian; Aukrust, Pål; Åkra, Sissel; Seljeflot, Ingebjørg; Solheim, Svein; Lorenzo, Andrea; Gullestad, Lars; Trøseid, Marius; Broch, Kaspar (Journal article; Peer reviewed, 2021)
      Background The gut microbiota represents a potential treatment target in heart failure (HF) through microbial metabolites such as trimethylamine N-oxide (TMAO) and systemic inflammation. Treatment with the probiotic yeast ...

    • Right atrium and cryptogenic ischaemic stroke in the young: A case-control study 

      Pöyhönen, Pauli; Kuusisto, Jouni; Pirinen, Jani; Räty, Heli; Lehmonen, Lauri; Paakkanen, Riitta; Martinez-Majander, Nicolas; Gerdts, Eva; Putaala, Jukka; Sinisalo, Juha; Järvinen, Vesa (Journal article; Peer reviewed, 2021)
      Background Recent studies suggest left atrial (LA) dysfunction in cryptogenic stroke. We studied the dynamics of right atrium (RA) and right atrial appendage (RAA) in young adults with cryptogenic stroke. We hypothesised ...

    • Risk assessment and antibody responses to SARS-CoV-2 in healthcare workers 

      Bansal, Amit; Trieu, Mai Chi; Mohn, Kristin Greve-Isdahl; Madsen, Anders; Olofsson, Jan Stefan; Sandnes, Helene Heitmann; Sævik, Marianne; Søyland, Hanne; Hansen, Lena; Onyango, Therese Bredholt; Tøndel, Camilla; Brokstad, Karl Albert; Syre, Heidi; Riis, Åse Garløv; Langeland, Nina; Cox, Rebecca Jane (Journal article; Peer reviewed, 2023)
      Background: Preventing infection in healthcare workers (HCWs) is crucial for protecting healthcare systems during the COVID-19 pandemic. Here, we investigated the seroepidemiology of SARS-CoV-2 in HCWs in Norway with ...

    • Risk estimates of imminent cardiovascular death and heart failure hospitalization are improved using serial natriuretic peptide measurements in patients With coronary artery disease and type 2 diabetes 

      Wolsk, Emil; Claggett, Brian; Diaz, Rafael; Dickstein, Kenneth; Gerstein, Hertzel C.; Køber, Lars; Lewis, Eldrin F.; Maggioni, Aldo P.; McMurray, John J.V.; Probstfield, Jeffrey L.; Riddle, Matthew C.; Solomon, Scott D.; Tardif, Jean-Claude; Pfeffer, Marc A. (Journal article; Peer reviewed, 2022)
      Background: Baseline and temporal changes in natriuretic peptide (NP) concentrations have strong prognostic value with regard to long‐term cardiovascular risk stratification. To increase the clinical utility of NP sampling ...

    • Risk factors and recurrence of cause-specific postpartum hemorrhage: A population-based study 

      Linde, Lorentz Erland; Rasmussen, Svein; Moster, Dag; Kessler, Jørg; Baghestan, Elham; Gissler, Mika; Ebbing, Cathrine (Journal article; Peer reviewed, 2022)
      Objective To explore risk profiles of the different types of postpartum hemorrhage (PPH >500ml or severe PPH >1500ml) and their recurrence risks in a subsequent delivery. Methods With data from The Medical Birth ...

    • Risk factors for development and maintenance of chronic whiplash 

      Myrtveit, Solbjørg Makalani (Doctoral thesis, 2015-05-13)
      Background: After experiencing whiplash accidents, most individuals recover rapidly. Others, however, develop chronic whiplash, a condition characterized by long lasting neck pain, somatic complaints and symptoms of anxiety ...

    • Risk factors for lung cancer in COPD - results from the Bergen COPD cohort study 

      Husebø, Gunnar Reksten; Nielsen, Rune; Hardie, Jon Andrew; Bakke, Per S.; Lerner, Lorena; D'Alessandro-Gabazza, Corina; Gyuris, Jeno; Gabazza, Esteban; Aukrust, Pål; Eagan, Tomas Mikal (Peer reviewed; Journal article, 2019)
      Background: COPD patients have an increased risk of developing lung cancer, but the underlying mechanisms are poorly understood. We aimed to identify risk factors for lung cancer in patients from the Bergen COPD Cohort ...

    • Risk factors for surgical site infection following cesarean delivery: A hospital-based case–control study 

      Kvalvik, Sedina Atic; Rasmussen, Svein; Thornhill, Heidi Frances; Baghestan, Elham (Journal article; Peer reviewed, 2021)
      Introduction Cesarean section is the single most important risk factor for postpartum infection. Where the rest of the world shows increasing trends, the cesarean section rates are low in Norway and risk factors for ...

    • Risk of atrial fibrillation and stroke among older men exposed to prolonged endurance sport practice: a 10-year follow-up. The Birkebeiner Ageing Study and the Tromsø Study 

      Johansen, Kristoffer Robin; Ranhoff, Anette Hylen; Sørensen, Eivind; Nes, Bjarne; Heitmann, Kim Arne; Apelland, Turid; Bucher Sandbakk, Silvana; Wilsgaard, Tom; Løchen, Maja-Lisa; Thelle, Dag Steinar; Morseth, Bente; Myrstad, Marius (Journal article; Peer reviewed, 2022)
      Aims: Endurance sport practice is associated with a high prevalence of atrial fibrillation (AF), which increases the risk of stroke in the general population. However, stroke risk in endurance athletes with AF is sparsely ...

    • Risk of miscarriage in women with psychiatric disorders 

      Magnus, Maria Christine; Havdahl, Alexandra; Morken, Nils-Halvdan; Wensaas, Knut-Arne; Wilcox, Allen J.; Håberg, Siri Eldevik (Journal article; Peer reviewed, 2021)
      Background Some psychiatric disorders have been associated with increased risk of miscarriage. However, there is a lack of studies considering a broader spectrum of psychiatric disorders to clarify the role of common as ...

    • Risk of Misclassification of decompression sickness 

      Sundal, Endre; Grønning, Marit; Troland, Kari; Irgens, Ågot; Aanderud, Leif; Thorsen, Einar (Peer reviewed; Journal article, 2011)
      Decompression sickness (DCS) is classified on the basis of which organ system is affected, and neurological DCS is considered more severe than DCS in joints and skin with respect to response to recompression treatment and ...

    • Risk of Subsequent Preeclampsia by Maternal Country of Birth: A Norwegian Population-Based Study 

      Mæland, Karolina Sofia; Morken, Nils-Halvdan; Schytt, Erica; Aasheim, Vigdis; Nilsen, Roy Miodini (Journal article; Peer reviewed, 2023)
      In this nationwide population-based study, we investigated the associations of preeclampsia in the first pregnancy with the risk of preeclampsia in the second pregnancy, by maternal country of birth using data from the ...

    • Risky Drinking among Norwegian Students: Associations with Participation in the Introductory Week, Academic Performance and Alcohol-related Attitudes 

      Myrtveit, Solbjørg Makalani; Askeland, Kristin Gärtner; Knudsen, Ann Kristin; Knapstad, Marit; Olsen, Rune; Nedregård, Truls; Skogen, Jens Christoffer (Peer reviewed; Journal article, 2016-09)
      AIMS – Substantial increase in heavy drinking upon transition from high school to college is common. Norwegian universities and university colleges arrange yearly introductory weeks to welcome new students. It has been ...