Blar i Department of Clinical Science på tittel

Viser treff 42-61 av 2308

    • Aiming towards evidence based interpretation of cardiac biomarkers in patients presenting with chest pain : The WESTCOR study 

      Tjora, Hilde Lunde (Doctoral thesis, 2022-08-23)
      Bakgrunn: Ca 10% av alle pasientar i akuttmottak blir innlagt med brystsmerter og spørsmål om akutt koronarsyndrom (AKS), men under ¼ av pasientane har AKS. Metode:WESTCOR studien er ein prospektiv observasjonsstudie som ...

    • Aiming toWards Evidence baSed inTerpretation of Cardiac biOmarkers in patients pResenting with chest pain using Point of Care Testing (WESTCOR-POC): study design 

      Thulin, Ingrid Viola Lavesson; Jordalen, Silje Marie Farestveit; Lekven, Ole Christian; Krishnapillai, Jeyaseelan; Steiro, Ole-Thomas; Collinson, Paul; Apple, Fred; Cullen, Louise; Norekvål, Tone Merete; Wisløff, Torbjørn; Vikenes, Kjell; Omland, Torbjørn; Bjørneklett, Rune Oskar; Aakre, Kristin Moberg (Journal article; Peer reviewed, 2023)
      Objectives: Patients presenting with symptoms suggestive of acute coronary syndrome (ACS) contribute to a high workload and overcrowding in the Emergency Department (ED). Accelerated diagnostic protocols for non-ST-elevation ...

    • Airway Inflammation and Bronchial Remodelling in Toluene Diisocyanate-exposed BALB/c Mouse Model 

      Sun, Li-Zhi; Elsayed, S.; Bronstad, A. M.; Van Do, T.; Irgens, Ågot; Aardal, N. P.; Aasen, T. B. (Peer reviewed; Journal article, 2007)
      Toluene diisocyanate (TDI), a highly reactive industrial chemical, is one of the leading causes of occupation-related asthma in industrialized countries. The pathogenesis of TDI-induced asthma, however, remains not fully ...

    • The airway microbiota of stable COPD : Association with exacerbation frequency and the risks associated with bronchoscopic data collection 

      Leiten, Elise Orvedal (Doctoral thesis, 2022-03-25)
      Background: Acute exacerbations of COPD are an important cause of mortality and morbidity in patients with COPD. It is incompletely understood why some COPD patients experience frequent exacerbations, while others rarely ...

    • Airway obstruction, dynamic hyperinflation, and breathing pattern during incremental exercise in COPD patients 

      Frisk, Bente; Espehaug, Birgitte; Hardie, Jon Andrew; Strand, Liv Inger; Moe-Nilssen, Rolf; Eagan, Tomas Mikal; Bakke, Per; Thorsen, Einar (Peer reviewed; Journal article, 2014-02-01)
      Ventilatory capacity is reduced in chronic obstructive pulmonary disease (COPD) patients. Tidal volume (VT) is lower and breathing frequency higher at a given ventilation (VE) compared to healthy subjects. We examined ...

    • Airway symptoms and atopy in young children prescribed asthma medications: A large‐scale cohort study 

      Mikalsen, Ingvild Bruun; Dalen, Ingvild; Karlstad, Øystein; Eide, Geir Egil; Magnus, Maria Christine; Nystad, Wenche; Øymar, Knut (Peer reviewed; Journal article, 2019)
      Diagnosing asthma and deciding treatment are difficult in young children. An inappropriate and too high prescription rate of inhaled corticosteroids (ICS) is suggested, but how airway symptoms are associated with prescriptions ...

    • The alarmins high mobility group box protein 1 and S100A8/A9 display different inflammatory profiles after acute knee injury 

      Aulin, C.; Larsson, S.; Vogl, T.; Roth, J.; Åkesson, A.; Swärd, P.; Heinbäck, R.; Harris, Helena Erlandsson; Struglics, A. (Journal article; Peer reviewed, 2022)
      Objective To compare the concentrations of high mobility group box 1 protein (HMGB1) and S100A8/A9 in synovial fluid between patients with knee injuries and osteoarthritis (OA), and knee healthy subjects. To investigate ...

    • Alcohol at bedtime induces minor changes in sleep stages and blood gases in stable chronic obstructive pulmonary disease 

      Holmedahl, Nils Henrik; Øverland, Britt; Fondenes, Ove; Ellingsen, Ivar; Hardie, Jon Andrew (Peer reviewed; Journal article, 2014-05-17)
      Purpose/background: The purpose of this study is to explore the effect of a moderate dose of alcohol on sleep architecture and respiration in chronic obstructive pulmonary disease (COPD). Alcohol depresses both hypercapnic ...

    • Algebraic topology-based machine learning using MRI predicts outcomes in primary sclerosing cholangitis 

      Singh, Yashbir; Jons, William A.; Eaton, John E.; Vesterhus, Mette Nåmdal; Karlsen, Tom Hemming; Bjørk, Ida; Abildgaard, Andreas; Jørgensen, Kristin Kaasen; Folseraas, Trine; Little, Derek; Gulamhusein, Aliya F.; Petrovic, Kosta; Negård, Anne; Conte, Gian Marco; Sobek, Joseph D.; Jagtap, Jaidip; Venkatesh, Sudhakar K.; Gores, Gregory J.; LaRusso, Nicholas F.; Lazaridis, Konstantinos N.; Erickson, Bradley J. (Journal article; Peer reviewed, 2022)
      Background: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease that can lead to cirrhosis and hepatic decompensation. However, predicting future outcomes in patients with PSC is challenging. Our ...

    • All-Optical Electrophysiology in hiPSC-Derived Neurons With Synthetic Voltage Sensors 

      Puppo, Francesca; Sadegh, Sanaz; Trujillo, Cleber A.; Thunemann, Martin; Campbell, Evan P.; Vandenberghe, Matthieu; Shan, Xiwei; Akkouh, Ibrahim; Miller, Evan W.; Bloodgood, Brenda L.; Silva, Gabriel A.; Dale, Anders M.; Einevoll, Gaute; Djurovic, Srdjan; Andreassen, Ole Andreas; Muotri, Alysson R.; Devor, Anna (Journal article; Peer reviewed, 2021)
      Voltage imaging and “all-optical electrophysiology” in human induced pluripotent stem cell (hiPSC)-derived neurons have opened unprecedented opportunities for high-throughput phenotyping of activity in neurons possessing ...

    • Allele diversity of the H-ras-1 variable number of tandem repeats in Norwegian lung cancer patients 

      Ryberg, D.; Tefre, T.; Skaug, V.; Stangeland, Lodve; Øvrebø, S.; Naalsund, A.; Børresen, A.-L.; Haugen, Aa. (Peer reviewed; Journal article, 1992-11)
      We have examined restriction fragment length polymorphisms of the H-ras-1 gene in germ-line DNA from 214 lung cancer patients and 309 unaffected controls. When DNA samples were digested with MspI/HpaII, Southern blot ...

    • Alterations in schizophrenia-associated genes can lead to increased power in delta oscillations 

      Mäki-Marttunen, Tuomo; Krull, Florian; Bettella, Francesco; Hagen, Espen; Næss, Solveig; Ness, Torbjørn V; Moberget, Torgeir; Elvsåshagen, Torbjørn; Metzner, Christoph; Devor, Anna; Edwards, Andrew G.; Fyhn, Marianne; Djurovic, Srdjan; Dale, Anders; Andreassen, Ole Andreas; Einevoll, Gaute (Peer reviewed; Journal article, 2019-02)
      Genome-wide association studies have implicated many ion channels in schizophrenia pathophysiology. Although the functions of these channels are relatively well characterized by single-cell studies, the contributions of ...

    • Altered biomarkers for cardiovascular disease and inflammation in autoimmune Addison's disease - a cross-sectional study 

      Sævik, Åse Bjorvatn; Ueland, Grethe Åstrøm; Åkerman, Anna-Karin; Methlie, Paal; Quinkler, Marcus; Jørgensen, Anders Palmstrøm; Höybye, Charlotte; Debowska, Aleksandra; Nedrebø, Bjørn Gunnar; Dahle, Anne Lise; Carlsen, Siri; Tomkowicz, Aneta; Sollid, Stina Therese; Nermoen, Ingrid; Grønning, Kaja; Dahlqvist, Per; Grimnes, Guri; Skov, Jakob; Finnes, Trine Elisabeth; Valland, Susanna Fonneland; Wahlberg, Jeanette; Holte, Synnøve Emblem; Kämpe, Olle; Bensing, Sophie; Husebye, Eystein Sverre; Øksnes, Marianne (Journal article; Peer reviewed, 2023)
      Objective: Increased prevalence of cardiovascular disease has been reported in autoimmune Addison's disease (AAD), but pathomechanisms are poorly understood. Design: Cross-sectional study. Methods: We compared serum ...

    • Altered development of fetal liver perfusion in pregnancies with pregestational diabetes 

      Lund, Agnethe; Ebbing, Cathrine; Rasmussen, Svein; Kiserud, Torvid; Hanson, Mark; Kessler, Jørg (Peer reviewed; Journal article, 2019-03-13)
      Background: Pregestational diabetes is associated with fetal macrosomia, and umbilical perfusion of the fetal liver has a role in regulating fetal growth. We therefore hypothesized that pregestational diabetes alters fetal ...

    • Altered Gut Microbial Metabolism of Essential Nutrients in Primary Sclerosing Cholangitis 

      Kummen, Martin; Thingholm, Louise B.; Rühlemann, Malte C.; Holm, Kristian; Hansen, Simen Hyll; Moitinho-Silva, Lucas; Liwinski, Timur; Zenouzi, Roman; Larsen, Christopher Storm; Midttun, Øivind; McCann, Adrian; Ueland, Per Magne; Høivik, Marte Lie; Vesterhus, Mette; Trøseid, Marius; Laudes, Matthias; Lieb, Wolfgang; Karlsen, Tom Hemming; Bang, Corinna; Schramm, Christoph; Franke, Andre; Hov, Johannes Espolin Roksund (Journal article; Peer reviewed, 2021)
      Background & Aims To influence host and disease phenotype, compositional microbiome changes, which have been demonstrated in patients with primary sclerosing cholangitis (PSC), must be accompanied by functional changes. ...

    • Altered immune activation and IL-23 signaling in response to Candida albicans in autoimmune polyendocrine syndrome type 1 

      Bruserud, Øyvind; Bratland, Eirik; Hellesen, Alexander; Delaleu, Nicolas; Reikvam, Håkon; Oftedal, Bergithe Eikeland; Wolff, Anette Susanne Bøe (Peer reviewed; Journal article, 2017-09-01)
      Objective: Autoimmune polyendocrine syndrome type 1 (APS-1) is a rare, childhood onset disease caused by mutations in the autoimmune regulator (AIRE) gene. Chronic mucocutaneous candidiasis (CMC) is one of the three major ...

    • Altered phenotype and Stat1 expression in Toll-like receptor 7/8 stimulated monocyte-derived dendritic cells from patients with primary Sjögren's syndrome 

      Vogelsang, Petra; Karlsen, Marie; Brun, Johan Gorgas; Jonsson, Roland; Appel, Silke (Peer reviewed; Journal article, 2014-08-11)
      Introduction: Dendritic cells (DC) are the most potent antigen-presenting cells of the immune system, involved in both initiating immune responses and maintaining tolerance. Dysfunctional and via toll-like receptor (TLR) ...

    • Alveolar function following extremely preterm birth 

      Satrell, Emma (Doctoral thesis, 2022-12-16)
      Bakgrunn: Ekstremt prematur (EP) fødsel skjer før normal lungeutvikling er fullført, og forstyrrer vekst og differensiering av alveolene. Mindre areal og tykkere membraner i alveolene gjør at lungenes evne til å drive ...

    • Amniotic fluid arginine from gestational weeks 13 to 15 is a predictor of birth weight, length, and head circumference 

      Jenssen, Astrid Bjørke; Ueland, Per Magne; Monsen, Anne Lise Bjørke (Peer reviewed; Journal article, 2017-12-14)
      Arginine is a constituent of proteins and a precursor for polyamines and nitric oxide, and is essential for placentation, angiogenesis, and growth. Maternal plasma arginine concentrations are found to be lower in pregnancies ...

    • AMPK som regulator av mitokondriell biogenese i en ny reporter-cellemodell 

      Ahmed, Bina Qassem (Master thesis, 2011-08-31)
      I dette prosjektet studerte vi rollen til den cellulære energisensoren Adenosine Monophosphate Aktivert Protein Kinase (AMPK) ved mitokondriell biogenese i en ny reportercellemodell, HelaNRF1mitoGFP. To kjente AMPK agonister, ...