Blar i Department of Clinical Science på utgivelsesdato
Viser treff 41-60 av 2295
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A pharmacokinetic study of NAD replenishment therapy using Nicotinamide Riboside
(Master thesis, 2023-05-22)Parkinson`s disease (PD) is a major cause of death and disability, and currently only symptomatic treatment is available. Nicotinamide adenine dinucleotide (NAD) is a crucial molecule for maintaining life and promoting ... -
Healthy Nordic diet and associations with plasma concentrations of metabolites in the choline oxidation pathway: a cross-sectional study from Northern Sweden
(Journal article; Peer reviewed, 2023-05-17)Background: The choline oxidation pathway and metabolites involved have been linked to diseases including cardiovascular disease, type 2 diabetes and cancer. A healthy Nordic diet is a recently defined dietary pattern ... -
Cryptosporidiosis in low-resource healthcare settings : Near-patient diagnostics, risk factors, and parasite shedding dynamics in young Ethiopian children
(Doctoral thesis, 2023-04-28)Bakgrunn: Tarmparasitten Cryptosporidium er en ledende årsak til diaré og dødsfall hos småbarn i lavinntektsland. Målretta behandling trengs, men forutsetter presise diagnostiske tester som er egna for ressursfattige ... -
In depth analyses of peripheral blood immune cell populations in patients with psoriasis - effect of biological treatment and alternative medicine
(Doctoral thesis, 2023-04-26)Psoriasis er en kronisk immun-mediert sykdom i huden med systemisk betennelse og ledsagende komorbiditeter. Selv om alvorlighetsgraden av sykdommen kan variere over tid, lider de fleste pasienter med psoriasis av mild til ... -
Identification of Cumin (Cuminum cyminum) MicroRNAs through Deep Sequencing and Their Impact on Plant Secondary Metabolism
(Journal article; Peer reviewed, 2023-04-25)The pharmacological properties of plants lie in the content of secondary metabolites that are classified into different categories based on their biosynthesis, structures, and functions. MicroRNAs (miRNAs) are small ... -
Family-based behavioral treatment of children with severe obesity : Effectiveness and perceived barriers
(Doctoral thesis, 2023-03-24)Bakgrunn: Få studier har prøvd ut familiebasert kognitiv atferdsterapi (FBT) innenfor den offentlige helsetjenesten. Mål: Sammenligne effekten av ... -
PIK3CA mutations and their impact on survival outcomes of patients with endometrial cancer: A systematic review and meta-analysis
(Journal article; Peer reviewed, 2023-03-21)Several studies have highlighted the frequent alterations of the PI3K pathway in endometrial cancer leading to increased signaling activation with potential for targeted treatment. The objective of this meta-study was to ... -
Functional analyses of BRCA1 variants of unknown significance found in hereditary breast or ovarian cancer families in Norway: A tool for improved diagnosis
(Doctoral thesis, 2023-03-21)Tumorsuppressorgenet BRCA1 speler mange viktige roller for å hindre tumorutvikling, og endringar i BRCA1-genet er ei av hovudårsakene til arveleg bryst- og eggstokk-kreft (HBOC). I artikkel I vart det laga ei oversikt over ... -
Validation of a modified South African triage scale in a high-resource setting: a retrospective cohort study
(Journal article; Peer reviewed, 2023-03-20)Background: Triage systems are widely used in emergency departments, but are not always validated. The South African Triage Scale (SATS) has mainly been studied in resource-limited settings. The aim of this study was to ... -
Fueling the flames of colon cancer – does CRP play a direct pro-inflammatory role?
(Journal article; Peer reviewed, 2023-03-17)Background: Systemic inflammation, diagnostically ascribed by measuring serum levels of the acute phase reactant C-reactive protein (CRP), has consistently been correlated with poor outcomes across cancer types. CRP exists ... -
Fluoroquinolone resistance among fecal extended spectrum βeta lactamases positive Enterobacterales isolates from children in Dar es Salaam, Tanzania
(Journal article; Peer reviewed, 2023-03-07)Background: Fluoroquinolones have been, and continue to be, routinely used for treatment of many bacterial infections. In recent years, most parts of the world have reported an increasing trend of fluoroquinolone resistant ... -
Epidemiology and etiology of primary ovarian insuffciency
(Doctoral thesis, 2023-03-02)Bakgrunn: Primær ovarialinsuffisiens (POI) er forårsaket av utilstrekkelig ovarieaktivitet og resulterer i for tidlig overgangsalder (alder <40 år). Diagnosen POI har livsendrende konsekvenser på grunn av infertilitet og ... -
Hyperglycemia in pregnancy. : Diagnostics, biomarkers, follow-up, and monitoring of glycemic control
(Doctoral thesis, 2023-02-24)Diabetes mellitus er blant de største globale folkehelseutfordringene i vår tid. Hyperglykemi affiserer ett av seks svangerskap og svangerskapsdiabetes (SVD) er den vanligste årsak. Gravide med hyperglykemi har økt risiko ... -
Phenotypic diversity of human adipose tissue-resident NK cells in obesity
(Journal article; Peer reviewed, 2023-02-22)Natural killer (NK) cells have emerged as key mediators of obesity-related adipose tissue inflammation. However, the phenotype of NK cell subsets residing in human adipose tissue are poorly defined, preventing a detailed ... -
Genetic determinants of macrolide and tetracycline resistance in penicillin non-susceptible Streptococcus pneumoniae isolates from people living with HIV in Dar es Salaam, Tanzania
(Journal article; Peer reviewed, 2023-02-20)Background: Over one million yearly deaths are attributable to Streptococcus pneumoniae and people living with HIV are particularly vulnerable. Emerging penicillin non-susceptible Streptococcus pneumoniae (PNSP) challenges ... -
Endothelial dysfunction in ME/CFS patients
(Journal article; Peer reviewed, 2023-02-02)Objective: A few earlier studies have found impaired endothelial function in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The present study investigated large-vessel and small-vessel endothelial ... -
Systemic metabolomic profiles in adult patients with bacterial sepsis: Characterization of patient heterogeneity at the time of diagnosis
(Journal article; Peer reviewed, 2023-01-24)Sepsis is a dysregulated host response to infection that causes potentially life-threatening organ dysfunction. We investigated the serum metabolomic profile at hospital admission for patients with bacterial sepsis. The ... -
Cleaning at work and at home as related to lung health : With a focus on asthma, COPD and lung function decline, vulnerability established early in life and potential impact for the next generation
(Doctoral thesis, 2023-01-20)Bakgrunn Renhold er en dagligdags oppgave for mange, men betyr også eksponering for renholdskjemikalier og desinfeksjonsmidler som kan være skadelige for luftveiene og forårsake lungesykdom. Astma er den vanligste ... -
Single-cell protein profiling in early therapy response evaluation of acute myeloid leukemia by mass cytometry
(Doctoral thesis, 2023-01-19)Akutt myelogen leukemi er ein aggressiv og heterogen form for blodkreft med om lag 150 nye tilfelle årleg i Noreg. Med ei total overlevingsrate på 25% har den dårlig prognose, særlig blant eldre. Behandlinga består av eit ... -
Functional Analyses of Rare Germline Missense BRCA1 Variants Located within and outside Protein Domains with Known Functions
(Journal article; Peer reviewed, 2023-01-19)The BRCA1 protein is implicated in numerous important cellular processes to prevent genomic instability and tumorigenesis, and pathogenic germline variants predispose carriers to hereditary breast and ovarian cancer (HBOC). ...