Blar i Department of Clinical Science på utgivelsesdato

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    • Functional Analyses of Rare Germline Missense BRCA1 Variants Located within and outside Protein Domains with Known Functions 

      Hovland, Henrikke Nilsen; Mchaina, Eunice Kabanyana; Vetti, Hildegunn Høberg; Ariansen, Sarah Louise; Sjursen, Wenche; Van Ghelue, Marijke; Haukanes, Bjørn Ivar; Knappskog, Per Morten; Aukrust, Ingvild; Berge, Elisabet Ognedal (Journal article; Peer reviewed, 2023-01-19)
      The BRCA1 protein is implicated in numerous important cellular processes to prevent genomic instability and tumorigenesis, and pathogenic germline variants predispose carriers to hereditary breast and ovarian cancer (HBOC). ...

    • Modulation of Unfolded Protein Response Restores Survival and Function of β-Cells Exposed to the Endocrine Disruptor Bisphenol A 

      Daian, Laura Maria; Tanko, Gabriela; Vacaru, Andrei Mircea; Ghila, Luiza Mihaela; Chera, Simona; Vacaru, Ana-Maria (Journal article; Peer reviewed, 2023-01-19)
      Diabetes is a metabolic disease that currently affects nearly half a billion people worldwide. β-cells dysfunction is one of the main causes of diabetes. Exposure to endocrine-disrupting chemicals is correlated with increased ...

    • GM-CSF, Flt3-L and IL-4 affect viability and function of conventional dendritic cell types 1 and 2 

      Lellahi, Seyed Mohammad; Azeem, Waqas; Hua, Yaping; Gabriel, Benjamin; Rye, Kristin Paulsen; Reikvam, Håkon; Kalland, Karl Henning (Journal article; Peer reviewed, 2023-01-12)
      Conventional type 1 dendritic cells (cDC1) and conventional type 2 dendritic cells (cDC2) have attracted increasing attention as alternatives to monocyte-derived dendritic cells (moDCs) in cancer immunotherapy. Use of cDCs ...

    • Host blood-based biosignatures for subclinical TB and incipient TB: A prospective study of adult TB household contacts in Southern India 

      Sivakumaran, Dhanasekaran; Jenum, Synne; Srivastava, Aashish; Steen, Vidar Martin; Vaz, Mario; Doherty, Timothy Mark; Ritz, Christian; Grewal, Harleen (Journal article; Peer reviewed, 2023-01-11)
      A large proportion of the global tuberculosis (TB) burden is asymptomatic and not detectable by symptom-based screening, driving the TB epidemic through continued M. tuberculosis transmission. Currently, no validated tools ...

    • Patients with Bacterial Sepsis Are Heterogeneous with Regard to Their Systemic Lipidomic Profiles 

      Mosevoll, Knut Anders; Hansen, Bent-Are; Gundersen, Ingunn Margareetta; Reikvam, Håkon; Bruserud, Øyvind; Bruserud, Øystein; Wendelbo, Øystein (Journal article; Peer reviewed, 2023)
      Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. In the present study, we investigated the systemic/serum lipidomic profile at the time of hospital admission for ...

    • Clinical outcomes among young patients with Fabry disease who initiated agalsidase beta treatment before 30 years of age: An analysis from the Fabry registry 

      Hopkin, Robert J.; Cabrera, Gustavo; Jefferies, John; Yang, Meng; Ponce, Elvira; Brand, Eva; Feldt-Rasmussen, Ulla; Germain, Dominique P.; Guffon, Nathalie; Jovanovic, Ana; Kantola, Ilkka; Karaa, Amel; Martins, Ana; Tøndel, Camilla; Wilcox, William R; Yoo, Han-Wook; Burlina, Alessandro; Mauer, Michael (Journal article; Peer reviewed, 2023)
      Background Clinical manifestations of classic Fabry disease (α-galactosidase A deficiency) usually occur in childhood, while complications involving major organs typically develop in adulthood. Outcomes of Fabry-specific ...

    • Perceived barriers in family-based behavioural treatment of paediatric obesity – Results from the FABO study 

      Skjåkødegård, Hanna Flækøy; Hystad, Sigurd William; Bruserud, Ingvild Særvold; Conlon, Rachel P. K.; Wilfley, Denise; Frisk, Bente; Roelants, Mathieu; Juliusson, Pétur Benedikt; Danielsen, Yngvild Sørebø (Journal article; Peer reviewed, 2023)
      Background: To date, few studies have investigated perceived barriers among those who participate in and drop out of family-based behavioural treatment (FBT) for paediatric obesity. Examining experienced barriers during ...

    • Multidisciplinary approaches to identifying and managing global airways disease: Expert recommendations based on qualitative discussions 

      Backer, Vibeke; Cardell, Lars Olaf; Lehtimäki, Lauri; Toppila-Salmi, Sanna K.; Bjermer, Leif; Reitsma, Sietze; Hellings, Peter Wim; Weinfeld, Dan; Aanæs, Kasper; Ulrik, Charlotte Suppli; Braunstahl, Gert-Jan; Aarli, Bernt Bøgvald; Danielsen, Arild; Kankaanranta, Hannu; Steinsvåg, Sverre Karmhus; Bachert, Claus (Journal article; Peer reviewed, 2023)
      Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) and asthma frequently co-exist and share pathologic features. Taking a “global” treatment approach benefits diagnosis and treatment of both, but care is often ...

    • Use of inhaled ipratropium bromide to improve exercise-induced laryngeal obstruction cannot be recommended 

      Muralitharan, Praveen; Carlsen, Petter; Hilland, Magnus; Delestre-Levai, Irisz; Vollsæter, Maria; Hufthammer, Karl Ove; Engan, Mette; Røksund, Ola Drange; Halvorsen, Thomas; Clemm, Hege Synnøve Havstad (Journal article; Peer reviewed, 2023)
      Introduction: Exercise-induced laryngeal obstruction (EILO) is a common cause of exertional breathing problems in young adults. Current management generally consists of breathing advice, speech therapy, inspiratory muscle ...

    • Mitral annular dynamics are influenced by left ventricular load and contractility in an acute animal model 

      Persson, Robert Matongo; Aguilera, Hans Martin Dahl; Kvitting, Jon Peder Escobar; Grong, Ketil; Prot, Victorien Emile; Salminen, Pirjo-Riitta; Svenheim, Bård; Leiknes, Anita; Stangeland, Lodve; Haaverstad, Rune; Urheim, Stig (Journal article; Peer reviewed, 2023)
      The purpose of this study was to investigate the effects of loading conditions and left ventricular (LV) contractility on mitral annular dynamics. In 10 anesthetized pigs, eight piezoelectric transducers were implanted ...

    • Recommendations for robust and reproducible preclinical research in personalised medicine 

      Fosse, Vibeke Samuelsen; Oldoni, Emanuela; Bietrix, Florence; Budillon, Alfredo; Daskalopoulos, Evnagelos P.; Fratelli, Maddalena; Gerlach, Björn; Groenen, Peter M.A.; Hölter, Sabine M.; Menon, Julia M.L.; Mobasheri, Ali; Osborne, Nikki; Ritskes-Hoitinga, Merel; Ryll, Bettina; Schmitt, Elmar; Ussi, Anton; Andreu, Antonio L.; Mccormack, Emmet Matin (Journal article; Peer reviewed, 2023)
      Background Personalised medicine is a medical model that aims to provide tailor-made prevention and treatment strategies for defined groups of individuals. The concept brings new challenges to the translational step, both ...

    • Efficacy and safety of baricitinib in hospitalized adults with severe or critical COVID‑19 (Bari‑SolidAct): a randomised, double‑blind, placebo‑controlled phase 3 trial 

      Trøseid, Marius; Arribas, José R.; Assoumou, Lambert; Holten, Aleksander Rygh; Poissy, Julien; Terzic, Vida; Mazzaferri, Fulvia; Baño, Jesús Rodríguez; Eustace, Joe; Hites, Maya; Joannidis, Michael; Paiva, José-Artur; Reuter, Jean; Püntmann, Isabel; Patrick-Brown, Thale Dawn; Westerheim, Elin; Nezvalova-Henriksen, Katerina; Beniguel, Lydie; Dahl, Tuva Børresdatter; Bouscambert, Maude; Halanova, Monika; Péterfi, Zoltán; Tsiodras, Sotirios; Rezek, Michael; Briel, Matthias; Ünal, Serhat; Schlegel, Martin; Ader, Florence; Lacombe, Karine; Amdal, Cecilie Delphin; Rodrigues, Serge; Tonby, Kristian; Gaudet, Alexandre; Heggelund, Lars; Mootien, Joy; Johannessen, Asgeir; Møller, Jannicke Horjen; Pollan, Beatriz Diaz; Tveita, Anders Aune; Kildal, Anders Benjamin; Richard, Jean-Christophe; Dalgard, Olav; Simensen, Victoria Charlotte; Baldé, Aliou; de Gastines, Lucie; del Álamo, Marta; Aydin, Burç; Lund-Johansen, Fridtjof; Trabaud, Mary-Anne; Diallo, Alpha; Halvorsen, Bente; Røttingen, John-Arne; Tacconelli, Evelina; Yazdanpanah, Yazdan; Olsen, Inge Christoffer; Costagliola, Dominique; Study Group, EU-SolidAct (Journal article; Peer reviewed, 2023)
      Background Baricitinib has shown efficacy in hospitalized patients with COVID-19, but no placebo-controlled trials have focused specifically on severe/critical COVID, including vaccinated participants. Methods Bari-SolidAct ...

    • The contribution of functional HNF1A variants and polygenic susceptibility to risk of type 2 diabetes in ancestrally diverse populations 

      Stalbow, Lauren; Preuss, Michael H.; Smit, Roelof A.J.; Chami, Nathalie; Bjørkhaug, Lise; Aukrust, Ingvild; Gloyn, Anna L; Loos, Ruth J.F. (Journal article; Peer reviewed, 2023)
      Aims/hypothesis: We examined the contribution of rare HNF1A variants to type 2 diabetes risk and age of diagnosis, and the extent to which their impact is affected by overall genetic susceptibility, across three ancestry ...

    • Inflammation and cognition in severe mental illness: patterns of covariation and subgroups 

      Sæther, Linn Sofie; Ueland, Thor; Haatveit, Beathe; Maglanoc, Luigi; Szabo, Attila; Djurovic, Srdjan; Aukrust, Pål; Roelfs, Daniël; Ormerod, Monica Bettina E. Greenwood; Lagerberg, Trine Vik; Steen, Nils Eiel; Melle, Ingrid; Andreassen, Ole; Ueland, Torill (Journal article; Peer reviewed, 2023)
      A potential relationship between dysregulation of immune/inflammatory pathways and cognitive impairment has been suggested in severe mental illnesses (SMI), such as schizophrenia (SZ) and bipolar (BD) spectrum disorders. ...

    • Changes in cardiopulmonary exercise capacity and limitations 3 to 12 months after COVID-19 

      Ingul, Charlotte Bjørk; Edvardsen, Anne; Follestad, Turid; Trebinjac, Divna; Ankerstjerne, Odd Andre Wathne; Brønstad, Eivind; Rasch-Halvorsen, Øystein; Aarli, Bernt Bøgvald; Dalen, Håvard; Nes, Bjarne; Lerum, Tøri Vigeland; Einvik, Gunnar; Stavem, Knut; Skjørten, Ingunn (Journal article; Peer reviewed, 2023)
      Rationale: To describe cardiopulmonary function during exercise 12 months after hospital discharge for coronavirus disease 2019 (COVID-19), assess the change from 3 to 12 months, and compare the results with matched controls ...

    • Prognostic value of baseline functional status measures and geriatric screening in vulnerable older patients with metastatic colorectal cancer receiving palliative chemotherapy – The randomized NORDIC9-study 

      Liposits, Gabor Isivan; Ryg, Jesper; Skuladottir, Halla; Winther, Stine B.; Möller, Sören; Hofsli, Eva; Shah, Carl-Henrik; Poulsen, Laurids Østergaard; Berglund, Åke; Qvortrup, Camilla; Osterlund, Pia; Glimelius, Bengt; Sorbye, Halfdan; Pfeiffer, Per (Journal article; Peer reviewed, 2023)
      Introduction Appropriate patient selection based on functional status is crucial when considering older adults for palliative chemotherapy. This pre-planned analysis of the randomized NORDIC9-study explored the prognostic ...

    • Bounding the average causal effect in Mendelian randomisation studies with multiple proposed instruments: An application to prenatal alcohol exposure and attention deficit hyperactivity disorder 

      Diemer, Elizabeth W.; Havdahl, Alexandra; Andreassen, Ole A.; Munafò, Marcus R.; Njølstad, Pål Rasmus; Tiemeier, Henning; Zuccolo, Luisa; Swanson, Sonja A. (Journal article; Peer reviewed, 2023)
      Background As large-scale observational data become more available, caution regarding causal assumptions remains critically important. This may be especially true for Mendelian randomisation (MR), an increasingly popular ...

    • Durable immune responses after BNT162b2 vaccination in home-dwelling old adults 

      Hansen, Lena; Brokstad, Karl Albert; Bansal, Amit; Zhou, Fan; Bredholt, Geir; Onyango, Therese Bredholt; Sandnes, Helene Heitmann; Elyanow, Rebecca; Madsen, Anders; Trieu, Mai Chi; Sævik, Marianne; Søyland, Hanne; Olofsson, Jan Stefan; Vahokoski, Juha; Ertesvåg, Nina Urke; Fjelltveit, Elisabeth Berg; Shafiani, Shahin; Tøndel, Camilla; Chapman, Heidi; Kaplan, Ian; Mohn, Kristin Greve-Isdahl; Langeland, Nina; Cox, Rebecca Jane (Journal article; Peer reviewed, 2023)
      Objectives Elderly are an understudied, high-risk group vulnerable to severe COVID-19. We comprehensively analyzed the durability of humoral and cellular immune responses after BNT162b2 vaccination and SARS-CoV-2 infection ...

    • Risk of Subsequent Preeclampsia by Maternal Country of Birth: A Norwegian Population-Based Study 

      Mæland, Karolina Sofia; Morken, Nils-Halvdan; Schytt, Erica; Aasheim, Vigdis; Nilsen, Roy Miodini (Journal article; Peer reviewed, 2023)
      In this nationwide population-based study, we investigated the associations of preeclampsia in the first pregnancy with the risk of preeclampsia in the second pregnancy, by maternal country of birth using data from the ...

    • Associations between health behaviours, fertility and reproductive outcomes: triangulation of evidence in the Norwegian Mother, Father and Child Cohort Study (MoBa) 

      Wootton, Robyn E.; Lawn, Rebecca B.; Magnus, Maria C.; Treur, Jorien L.; Corfield, Elizabeth C.; Njølstad, Pål Rasmus; Andreassen, Ole A.; Lawlor, Deborah A.; Munafò, Marcus R.; Håberg, Siri E.; Smith, George Davey; Reichborn-Kjennerud, Ted; Magnus, Per; Havdahl, Alexandra (Journal article; Peer reviewed, 2023)
      Background Guidance to improve fertility includes reducing alcohol and caffeine consumption, achieving healthy weight-range and stopping smoking. Advice is informed by observational evidence, which is often biased by ...