Browsing Faculty of Mathematics and Natural Sciences by Title
Now showing items 3300-3319 of 9927
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Functional and molecular characterisation of a unique double homozygous variant causing ABCA4-related retinopathy
(Master thesis, 2023-06-02) -
Functional assessment of 3'UTR regulatory elements using the zebrafish (Danio rerio) model system - towards modulating protein levels in Atlantic salmon (Salmo salar) for more sustainable aquaculture
(Master thesis, 2021-11-22)Post-transcriptional regulation is a complex process that encompasses a myriad of different structures and mechanisms. There are several indications that regulatory elements in the 3'UTR play an important role in the ... -
Functional characterisation of polybasic motifs in the nucleolar PtdIns(3,4,5)P3- interacting proteins proliferation-associated protein 2G4 and poly(ADP-ribose) polymerase 1
(Doctoral thesis, 2023-06-13)Fosfoinositid 3-kinase (PI3K)-signalveien er viktig for flere cellulære prosesser, inklusiv celleoverlevelse, proliferasjon og proteinsyntese. Den er godt beskrevet i cytoplasmaet. I tillegg kan fosfatidylinositol ... -
Functional characterisation of three human nicotinamide mononucleotide adenylyltransferases
(Doctoral thesis, 2008-08-25)Nicotinamide adenine dinucleotide, NAD, is an essential redox factor in many, primarily catabolic, hydrogen transfer reactions. While the redox reactions are not accompanied by a net loss of the pyridine nucleotides, NAD+ ... -
Functional characterization of Atlantic salmon (Salmo salar L.) PepT2 transporters
(Journal article; Peer reviewed, 2022)The high-affinity/low-capacity system Slc15a2 (PepT2) is responsible for the reuptake of di/tripeptides from the renal proximal tubule, but it also operates in many other tissues and organs. Information regarding PepT2 in ... -
Functional characterization of Carboxyl Ester Lipase variants causing diabetes and exocrine dysfunction
(Master thesis, 2016-11-21)The digestive enzyme carboxyl ester lipase (CEL) is mainly expressed in the acinar cells of the pancreas. We have previously identified disease-causing mutations in a variable number of tandem repeats (VNTR) domain, localised ... -
Functional characterization of ErbB3-binding protein 1 (EBP1) tumor mutants
(Master thesis, 2021-06-15)Four C-terminal EBP1 mutants, Q367H, Q367K, K373E-Ins K372R-Del, discovered in various cancer tumors werer investigated by PipStrip assay, whre Q367K had increased binding. Thermal denaturation and immonostaing localization. -
Functional characterization of N-terminal acetyltransferase 10 (NAA10) variants potentially causing disease
(Master thesis, 2019-12-14)Approximately 80-90 % of all eukaryotic proteins are co- or post-translationally acetylated on their N-terminus by a group of enzymes called N-terminal acetyltransferases (NATs) (Arnesen et al., 2009). To date, eight NATs ... -
Functional characterization of rare variants of SCHAD, a protein involved in unregulated insulin secretion
(Master thesis, 2018-06-26)Congenital Hyperinsulinism of Infancy (CHI) is a group of rare inherited disorders characterized by persistent hypoglycaemia due to inappropriate elevated secretion of insulin from the pancreatic beta cells. CHI can be ... -
Functional dissection of a genetic locus for visceral fat mass (11q23.3)
(Master thesis, 2021-06-01) -
Functional Evolution of Clustered Aquaporin Genes Reveals Insights into the Oceanic Success of Teleost Eggs
(Journal article; Peer reviewed, 2023)Aquaporin-mediated oocyte hydration is considered important for the evolution of pelagic eggs and the radiative success of marine teleosts. However, the molecular regulatory mechanisms controlling this vital process are ... -
Functional inequalities on path space of sub-Riemannian manifolds and applications
(Journal article; Peer reviewed, 2021)We consider the path space of a manifold with a measure induced by a stochastic flow with an infinitesimal generator that is hypoelliptic, but not elliptic. These generators can be seen as sub-Laplacians of a sub-Riemannian ... -
Functional investigations of the Ecdysone Receptor and production of ecdysone in the salmon louse (Lepeophtheirus salmonis)
(Doctoral thesis, 2016-05-24)The salmon louse Lepeophtheirus salmonis is a marine ectoparasitic copepod naturally infecting salmonid fishes in the Northern hemisphere. At present, salmon louse infections are the most severe disease problem in the ... -
Functional modifications associated with gastrointestinal tract organogenesis during metamorphosis in Atlantic halibut (Hippoglossus hippoglossus)
(Peer reviewed; Journal article, 2014-02-19)Background: Flatfish metamorphosis is a hormone regulated post-embryonic developmental event that transforms a symmetric larva into an asymmetric juvenile. In altricial-gastric teleost fish, differentiation of the stomach ... -
Functional Sites in Proteins: analysis and annotation of five nuclear functional sites for the ELM resource
(Master thesis, 2004)Proteins are molecular tools which a cell expresses from specific genes, where the protein has one or several functions. An example of a protein function can be to detect a particular hormone, transporting itself to the ... -
Functional specialization of Aurora kinase homologs during oogenic meiosis in the tunicate Oikopleura dioica
(Journal article; Peer reviewed, 2023)A single Aurora kinase found in non-vertebrate deuterostomes is assumed to represent the ancestor of vertebrate Auroras A/B/C. However, the tunicate Oikopleura dioica, a member of the sister group to vertebrates, possesses ... -
Functional studies of two wild type variants of HIV-1 Tat
(Master thesis, 2003) -
Functional traits of alpine plant communities show long-term resistance to changing herbivore densities
(Journal article; Peer reviewed, 2021)Herbivores shape vegetation by suppressing certain plant species while benefitting others. By thus modifying plant species functional composition, herbivores affect carbon cycling, albedo, vegetation structure and species' ...