Blar i Faculty of Mathematics and Natural Sciences på tittel
Viser treff 3302-3321 av 9919
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Functional characterization of Atlantic salmon (Salmo salar L.) PepT2 transporters
(Journal article; Peer reviewed, 2022)The high-affinity/low-capacity system Slc15a2 (PepT2) is responsible for the reuptake of di/tripeptides from the renal proximal tubule, but it also operates in many other tissues and organs. Information regarding PepT2 in ... -
Functional characterization of Carboxyl Ester Lipase variants causing diabetes and exocrine dysfunction
(Master thesis, 2016-11-21)The digestive enzyme carboxyl ester lipase (CEL) is mainly expressed in the acinar cells of the pancreas. We have previously identified disease-causing mutations in a variable number of tandem repeats (VNTR) domain, localised ... -
Functional characterization of ErbB3-binding protein 1 (EBP1) tumor mutants
(Master thesis, 2021-06-15)Four C-terminal EBP1 mutants, Q367H, Q367K, K373E-Ins K372R-Del, discovered in various cancer tumors werer investigated by PipStrip assay, whre Q367K had increased binding. Thermal denaturation and immonostaing localization. -
Functional characterization of N-terminal acetyltransferase 10 (NAA10) variants potentially causing disease
(Master thesis, 2019-12-14)Approximately 80-90 % of all eukaryotic proteins are co- or post-translationally acetylated on their N-terminus by a group of enzymes called N-terminal acetyltransferases (NATs) (Arnesen et al., 2009). To date, eight NATs ... -
Functional characterization of rare variants of SCHAD, a protein involved in unregulated insulin secretion
(Master thesis, 2018-06-26)Congenital Hyperinsulinism of Infancy (CHI) is a group of rare inherited disorders characterized by persistent hypoglycaemia due to inappropriate elevated secretion of insulin from the pancreatic beta cells. CHI can be ... -
Functional dissection of a genetic locus for visceral fat mass (11q23.3)
(Master thesis, 2021-06-01) -
Functional Evolution of Clustered Aquaporin Genes Reveals Insights into the Oceanic Success of Teleost Eggs
(Journal article; Peer reviewed, 2023)Aquaporin-mediated oocyte hydration is considered important for the evolution of pelagic eggs and the radiative success of marine teleosts. However, the molecular regulatory mechanisms controlling this vital process are ... -
Functional inequalities on path space of sub-Riemannian manifolds and applications
(Journal article; Peer reviewed, 2021)We consider the path space of a manifold with a measure induced by a stochastic flow with an infinitesimal generator that is hypoelliptic, but not elliptic. These generators can be seen as sub-Laplacians of a sub-Riemannian ... -
Functional investigations of the Ecdysone Receptor and production of ecdysone in the salmon louse (Lepeophtheirus salmonis)
(Doctoral thesis, 2016-05-24)The salmon louse Lepeophtheirus salmonis is a marine ectoparasitic copepod naturally infecting salmonid fishes in the Northern hemisphere. At present, salmon louse infections are the most severe disease problem in the ... -
Functional modifications associated with gastrointestinal tract organogenesis during metamorphosis in Atlantic halibut (Hippoglossus hippoglossus)
(Peer reviewed; Journal article, 2014-02-19)Background: Flatfish metamorphosis is a hormone regulated post-embryonic developmental event that transforms a symmetric larva into an asymmetric juvenile. In altricial-gastric teleost fish, differentiation of the stomach ... -
Functional Sites in Proteins: analysis and annotation of five nuclear functional sites for the ELM resource
(Master thesis, 2004)Proteins are molecular tools which a cell expresses from specific genes, where the protein has one or several functions. An example of a protein function can be to detect a particular hormone, transporting itself to the ... -
Functional specialization of Aurora kinase homologs during oogenic meiosis in the tunicate Oikopleura dioica
(Journal article; Peer reviewed, 2023)A single Aurora kinase found in non-vertebrate deuterostomes is assumed to represent the ancestor of vertebrate Auroras A/B/C. However, the tunicate Oikopleura dioica, a member of the sister group to vertebrates, possesses ... -
Functional studies of two wild type variants of HIV-1 Tat
(Master thesis, 2003) -
Functional traits of alpine plant communities show long-term resistance to changing herbivore densities
(Journal article; Peer reviewed, 2021)Herbivores shape vegetation by suppressing certain plant species while benefitting others. By thus modifying plant species functional composition, herbivores affect carbon cycling, albedo, vegetation structure and species' ... -
Functional traits, not productivity, predict alpine plant community openness to seedling recruitment under climatic warming
(Peer reviewed; Journal article, 2020)Understanding the degree to which plant communities are open to seedling recruitment is key to predicting how they will be impacted by climate change. We experimentally assessed whether communities assembled under colder ... -
Functionalization of the Imidazole Backbone by Means of a Tailored and Optimized Oxidative Heck Cross-Coupling
(Journal article; Peer reviewed, 2020)A general and selective Pd-catalyzed cross-coupling of aromatic boronic acids with vinyl-imidazoles is disclosed. Unlike most cross-coupling reactions, this method operates well in absence of bases avoiding the formation ... -
Fundamental aspects of water methane separation in zeolites
(Master thesis, 2013-06-03)The main objective of this thesis was to use molecular dynamics to investigate the methane interactions with zeolite, specifically the Linde Type A-3A, alongside with an investigation into the use of polynomial path ... -
Funksjonell karakterisering av østrogenreseptor α fra atlanterhavstorsk (Gadus morhua); kloning, ligandaktivering og induksjon av østrogenreseptorsignalveien i presisjonskuttede leverskiver
(Master thesis, 2017-11-07)Østrogenreseptor α (ERα) er en steroidreseptor som spiller en viktig rolle i regulering av genuttrykning under kjønnsutvikling og vitellogenese hos teleoster. Den aktiveres naturlig av endogene østrogener, men kan også ...