Browsing Faculty of Medicine by Title
Now showing items 745-764 of 8754
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Bidirectional Dysregulation of AMPA Receptor-Mediated Synaptic Transmission and Plasticity in Brain Disorders
(Journal article; Peer reviewed, 2020-07-10)AMPA receptors (AMPARs) are glutamate-gated ion channels that mediate the majority of fast excitatory synaptic transmission throughout the brain. Changes in the properties and postsynaptic abundance of AMPARs are pivotal ... -
Bidirectional genetic overlap between autism spectrum disorder and cognitive traits
(Journal article; Peer reviewed, 2023)Autism spectrum disorder (ASD) is a highly heritable condition with a large variation in cognitive function. Here we investigated the shared genetic architecture between cognitive traits (intelligence (INT) and educational ... -
Bile Acid Profiles in Primary Sclerosing Cholangitis and their Ability to Predict Hepatic Decompensation
(Journal article; Peer reviewed, 2021)Background and Aims: Altered bile acid (BA) homeostasis is an intrinsic facet of cholestatic liver diseases, but clinical usefulness of plasma BA assessment in primary sclerosing cholangitis (PSC) remains understudied. We ... -
Bimodal expression of potential drug target CLL-1 (CLEC12A) on CD34+ blasts of AML patients
(Journal article; Peer reviewed, 2021)Objectives This study aims to retrospectively assess C-lectin-like molecule 1 (CLL-1) bimodal expression on CD34+ blasts in acute myeloid leukemia (AML) patients (total N = 306) and explore potential CLL-1 bimodal ... -
Bio-psycho-social factors’ associations with brain age: a large-scale UK Biobank diffusion study of 35,749 participants
(Journal article; Peer reviewed, 2023)Brain age refers to age predicted by brain features. Brain age has previously been associated with various health and disease outcomes and suggested as a potential biomarker of general health. Few previous studies have ... -
Bioactive copolymer scaffolds for bone tissue engineering. Efficacy and host response
(Doctoral thesis, 2015-12-11)Current research focuses on developing a novel bone-inducing scaffold that could deliver controlled osteogenic growth factors. Several aspects, in particular those influencing the efficacy of such bioactive scaffolds, such ... -
Bioactive fatty acids and coronary heart disease. Mechanisms and clinical effects of dietary fatty acids
(Doctoral thesis, 2013-06-26)Background: A high intake of omega-3 (n-3) long-chain polyunsaturated fatty acids (LCPUFAs), which are potential peroxisome proliferator-activated receptor (PPAR) agonists, has been associated with proposed favourable ... -
Bioactive peptides from microalgae: Focus on anti-cancer and immunomodulating activity
(Journal article; Peer reviewed, 2021)In addition to the rapidly expanding field of using microalgae for food and feed, microalgae represent a tremendous potential for new bioactive compounds with health-promoting effects. One field where new therapeutics is ... -
Bioaerosols in the Slaughter Department of Processing Factories for Farmed Salmon. Bacteria and Endotoxins
(Master thesis, 2021-05-15)Bakgrunn Er det mulig at patogene og opportunistiske bakterier kommer inn i lakseslakteriene med fisk og sjøvann og aerosoliseres langs prosesslinjen? Målet i denne studien var å skaffe mer kunnskap om bioaerosolsammensetningen ... -
Bioavailability of iodine from a meal consisting of sushi and a wakame seaweed salad—A randomized crossover trial
(Journal article; Peer reviewed, 2023)The consumption of seaweed is on the rise in the Western world. Seaweeds may contain substantial amounts of iodine, and some species could serve as a potential dietary iodine source. However, limited data on the iodine ... -
Bioavailability of iron, zinc, folate and vitamin A when fortified in condiments and seasonings
(Peer reviewed; Journal article, 2015-11)Seasonings and condiments can be candidate vehicles for micronutrient fortification if consumed consistently and if dietary practices ensure bioavailability of the nutrient. In this review, we identify factors that may ... -
A biobank of primary teeth within the Norwegian mother and child cohort study (MoBa) per 2014: A resource for the future
(Peer reviewed; Journal article, 2014)The Norwegian Mother and Child Cohort Study (MoBa) is a prospective population-based cohort study including more than 100,000 pregnancies and following the children through childhood, using questionnaires and collecting ... -
Biochemical analysis of novel NAA10 variants suggests distinct pathogenic mechanisms involving impaired protein N‑terminal acetylation
(Journal article; Peer reviewed, 2022)NAA10 is the catalytic subunit of the N-terminal acetyltransferase complex, NatA, which is responsible for N-terminal acetylation of nearly half the human proteome. Since 2011, at least 21 different NAA10 missense variants ... -
Biochemical and biophysical characterisation of HMBS variants associated with acute intermittent porphyria
(Master thesis, 2022-06-01) -
BioContainers: An open-source and community-driven framework for software standardization
(Peer reviewed; Journal article, 2017-03-30)Motivation BioContainers (biocontainers.pro) is an open-source and community-driven framework which provides platform independent executable environments for bioinformatics software. BioContainers allows labs of all sizes ... -
Biofilm and dental biomaterials
(Peer reviewed; Journal article, 2015-05-26)All treatment involving the use of biomaterials in the body can affect the host in positive or negative ways. The microbiological environment in the oral cavity is affected by the composition and shape of the biomaterials ... -
Biofilm and planktonic lifestyles of Porphyromonas gingivalis and Fusobacterium nucleatum. Proteomic analysis of bacteria grown as planktonic cells, mono- and dual species biofilm, and characterization of the biofilm extracellular polymeric matrix’
(Doctoral thesis, 2018-04-06)Periodontitis is one of the most prevalent infectious diseases affecting humans. Periodontitis leads to the destruction of the dental support tissues, which in the terminal stage causes loss of teeth. Periodontitis is ... -
Bioinformatic analyses of miRNA-mRNA signature during hiPSC differentiation towards insulin-producing cells upon HNF4α mutation
(Journal article; Peer reviewed, 2020)Mutations in the hepatocyte nuclear factor 4α (HNF4α) gene affect prenatal and postnatal pancreas development, being characterized by insulin-producing β-cell dysfunction. Little is known about the cellular and molecular ... -
Bioinformatic and Genetic Association Analysis of MicroRNA Target Sites in One-Carbon Metabolism Genes
(Peer reviewed; Journal article, 2011-07-12)One-carbon metabolism (OCM) is linked to DNA synthesis and methylation, amino acid metabolism and cell proliferation. OCM dysfunction has been associated with increased risk for various diseases, including cancer and neural ... -
Biological Characteristics of Stem-Like Cells in Oral Squamous Cell Carcinoma
(Doctoral thesis, 2013-06-18)It has been shown that many solid malignancies, including oral squamous cell carcinoma (OSCC), contain a small population of tumorigenic cells referred to as cancer stem-like cells (CSCs) or tumor initiating cells (TICs). ...