Blar i Faculty of Medicine på tittel

Viser treff 608-627 av 8826

    • Atypical (non-V600E) BRAF mutations in metastatic colorectal cancer in population and real-world cohorts 

      Osterlund, Emerik; Ristimäki, Ari; Mäkinen, Markus J.; Kytölä, Soili; Kononen, Juha; Pfeiffer, Per; Soveri, Leena-Maija; Keinänen, Mauri; Sorbye, Halfdan; Nunes, Luís; Salminen, Tapio; Nieminen, Lasse; Uutela, Aki; Halonen, Päivi; Ålgars, Annika; Sundström, Jari; Kallio, Raija; Ristamäki, Raija; Lamminmäki, Annamarja; Stedt, Hanna; Heervä, Eetu; Kuopio, Teijo; Sjöblom, Tobias; Isoniemi, Helena; Glimelius, Bengt; Osterlund, Pia (Journal article; Peer reviewed, 2023)
      BRAF-V600E mutation (mt) is a strong negative prognostic and predictive biomarker in metastatic colorectal cancer (mCRC). Non-V600Emt, designated atypical BRAFmt (aBRAFmt) are rare, and little is known about their frequency, ...

    • Atypical glandular lesions of the cervix and risk of cervical cancer 

      Graue, Renate; Lönnberg, Stefan; Skare, Gry Baadstrand; Sæther, Solbjørg Makalani Myrtveit; Bjørge, Tone (Journal article; Peer reviewed, 2020)
      Introduction Cytology screening has been effective in reducing risks for cervical squamous cell carcinoma but less so for adenocarcinoma. We explored the association of atypical glandular cells or absence of glandular ...

    • Augmented CD4+ T-cell and humoral responses after repeated annual influenza vaccination with the same vaccine component A/H1N1pdm09 over 5 years 

      Trieu, Mai Chi; Zhou, Fan; Jalloh, Sarah Larteley Lartey; Sridhar, Saranya; Mjaaland, Siri; Cox, Rebecca Jane (Peer reviewed; Journal article, 2018-08-14)
      Annual seasonal influenza vaccination is recommended for high-risk populations and often occupational groups such as healthcare workers (HCWs). Repeated annual vaccination has been reported to either have no impact or ...

    • Augmented reality versus standard tests to assess cognition and function in early Alzheimer’s disease 

      Muurling, Marijn; de Boer, Casper; Vairavan, Srinivasan; Harms, Robbert L.; Chadha, Antonella Santuccione; Tarnanas, Ioannis; Luis, Estefania Vilarino; Religa, Dorota; Gjestsen, Martha Therese; Galluzzi, Samantha; Ibarria Sala, Marta; Koychev, Ivan; Hausner, Lucrezia; Gkioka, Mara; Aarsland, Dag; Visser, Pieter Jelle; Brem, Anna-Katharine (Journal article; Peer reviewed, 2023)
      Augmented reality (AR) apps, in which the virtual and real world are combined, can recreate instrumental activities of daily living (IADL) and are therefore promising to measure cognition needed for IADL in early Alzheimer’s ...

    • The autism birth cohort (ABC): A study of autism spectrum disorders in MoBa 

      Suren, Pål; Schjølberg, Synnve; Øyen, Anne-Siri; Lie, Kari Kveim; Hornig, Mady; Bresnahan, Michaeline; Bakke, Therese Wardenær; Roth, Christine; Alsaker, Elin Hilde Roti; Schreuder, Patricia; Stenberg, Nina; Reichborn-Kjennerud, Ted; Hirtz, Deborah; Susser, Ezra; Magnus, Per; Lipkin, Ian; Stoltenberg, Camilla (Peer reviewed; Journal article, 2014)
      Background: Autism spectrum disorders (ASDs) are characterized by persistent deficits in social communication and interaction and restricted, repetitive patterns of behavior, interests or activities. In most cases, the ...

    • Autism risk associated with parental age and with increasing difference in age between the parents 

      Sandin, S; Schendel, D; Magnusson, P; Hultman, C; Surén, Pål; Susser, Ezra; Grønborg, T; Gissler, M; Gunnes, Nina; Gross, R; Henning, M; Bresnahan, M; Sourander, A; Hornig, M; Carter, K; Francis, R; Parner, E; Leonard, H; Rosanoff, M; Stoltenberg, Camilla; Reichenberg, A (Peer reviewed; Journal article, 2015)
      Advancing paternal and maternal age have both been associated with risk for autism spectrum disorders (ASD). However, the shape of the association remains unclear, and results on the joint associations is lacking. This ...

    • Autoantibodies against type I IFNs in patients with life-threatening COVID-19 

      Bastard, Paul; Rosen, Lindsey B.; Zhang, Qian; Michailidis, Eleftherios; Hoffmann, Hans-Heinrich; Zhang, Yu; Dorgham, Karim; Philippot, Quentin; Rosain, Jérémie; Béziat, Vivien; Manry, Jérémy; Shaw, Elana; Haljasmägi, Liis; Peterson, Pärt; Lorenzo, Lazaro; Bizien, Lucy; Trouillet-Assant, Sophie; Dobbs, Kerry; de Jesus, Adriana Almeida; Belot, Alexandre; Kallaste, Anne; Catherinot, Emilie; Tandjaoui-Lambiotte, Yacine; Le Pen, Jeremie; Kerner, Gaspard; Bigio, Benedetta; Seeleuthner, Yoann; Yang, Rui; Bolze, Alexandre; Spaan, András N; Delmonte, Ottavia M.; Abers, Michael S.; Aiuti, Alessandro; Casari, Giorgio; Lampasona, Vito; Piemonti, Lorenzo; Ciceri, Fabio; Bilguvar, Kaya; Lifton, Richard P.; Vasse, Marc; Smadja, David M.; Migaud, Mélanie; Hadjadj, Jérome; Terrier, Benjamin; Duffy, Darragh; Quintana-Murci, Lluis; van de Beek, Diederik; Roussel, Lucie; Vinh, Donald C.; Tangye, Stuart G.; Haerynck, Filomeen; Dalmau, David; Martinez-Picado, Javier; Brodin, Petter; Nussenzweig, Michel C.; Boisson-Dupuis, Stéphanie; Rodríguez-Gallego, Carlos; Vogt, Guillaume; Mogensen, Trine H.; Oler, Andrew J.; Gu, Jingwen; Burbelo, Peter D.; Cohen, Jeffrey I.; Biondi, Andrea; Bettini, Laura Rachele; D'Angio, Mariella; Bonfanti, Paolo; Rossignol, Patrick; Mayaux, Julien; Rieux-Laucat, Frédéric; Husebye, Eystein Sverre; Fusco, Francesca; Ursini, Matilde Valeria; Imberti, Luisa; Sottini, Alessandra; Paghera, Simone; Quiros-Roldan, Eugenia; Rossi, Camillo; Castagnoli, Riccardo; Montagna, Daniela; Licari, Amelia; Marseglia, Gian Luigi; Duval, Xavier; Ghosn, Jade; Tsang, John S.; Goldbach-Mansky, Raphaela; Kisand, Kai; Lionakis, Michail; Puel, Anne; Zhang, Shen-Ying; Holland, Steven M.; Gorochov, Guy; Jouanguy, Emmanuelle; Rice, Charles M.; Cobat, Aurelie; Notarangelo, Luigi D.; Abel, Laurent; Su, Helen C.; Casanova, Jean-Laurent (Journal article; Peer reviewed, 2020)
      Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease ...

    • Autoantibody discovery across monogenic, acquired, and COVID-19-associated autoimmunity with scalable PhIP-seq 

      Vazquez, Sara E.; Mann, Sabrina A.; Bodansky, Aaron; Kung, Andrew F.; Quandt, Zoe; Ferré, Elise M N; Landegren, Nils; Eriksson, Daniel; Bastard, Paul; Zhang, Shen-Ying; Liu, Jamin; Mitchell, Anthea; Proekt, Irina; Yu, David; Mandel-Brehm, Caleigh; Wang, Chung-Yu; Miao, Brenda; Sowa, Gavin; Zorn, Kelsey; Chan, Alice Y.; Tagi, Veronica M.; Shimizu, Chisato; Tremoulet, Adriana; Lynch, Kara; Wilson, Michael R.; Kämpe, Olle; Dobbs, Kerry; Delmonte, Ottavia M.; Bacchetta, Rosa; Notarangelo, Luigi D.; Burns, Jane C.; Casanova, Jean-Laurent; Lionakis, Michail S.; Torgerson, Troy R.; Anderson, Mark S.; DeRisi, Joseph L. (Journal article; Peer reviewed, 2022)
      Phage immunoprecipitation sequencing (PhIP-seq) allows for unbiased, proteome-wide autoantibody discovery across a variety of disease settings, with identification of disease-specific autoantigens providing new insight ...

    • Autoantigenic properties of the aminoacyl tRNA synthetase family in idiopathic inflammatory myopathies 

      Preger, Charlotta; Notarnicola, Antonella; Hellström, Cecilia; Wigren, Edvard; Fernandes-Cerqueira, Cátia; Kvarnström, Marika; Wahren Herlenius, Marie Elisabeth; Idborg, Helena; Lundberg, Ingrid E.; Persson, Helena; Gräslund, Susanne; Jakobsson, Per-Johan (Journal article; Peer reviewed, 2023)
      Objectives: Autoantibodies are thought to play a key role in the pathogenesis of idiopathic inflammatory myopathies (IIM). However, up to 40% of IIM patients, even those with clinical manifestations of anti-synthetase ...

    • Autocrine activation of MAPK signaling mediates intrinsic tolerance to androgen deprivation in LY6D prostate cancer cells 

      Steiner, Ivana; Flores-Tellez, Teresita del N.J.; Mevel, Renaud; Ali, Amin; Wang, Pengbo; Schofield, Pieta; Behan, Caron; Forsythe, Nicholas; Ashton, Garry; Taylor, Catherine; Mills, Ian Geoffrey; Oliveira, Pedro; McDade, Simon S.; Zaiss, Dietmar M.; Choudhury, Ananya; Lacaud, Georges; Baena, Esther (Journal article; Peer reviewed, 2023)
      The emergence of castration-resistant prostate cancer remains an area of unmet clinical need. We recently identified a subpopulation of normal prostate progenitor cells, characterized by an intrinsic resistance to androgen ...

    • Autoimmune Addison's Disease and DNA Methylation. Identification of Differentially Methylated Regions and Development of Methylation Specific PCR for Selected Genes 

      Islam, Shahinul (Master thesis, 2012-07-01)
      Autoimmune Addison's Disease (AAD) is a classical organ-specific autoimmune disease (AID) that is characterized by autoreactivity towards the adrenal cortex, leading to insufficient production of steroid hormones and death ...

    • Autoimmune polyendocrine syndrome type I. Novel diagnostic assays and immune regulation 

      Oftedal, Bergithe E. V. (Doctoral thesis, 2012-02-10)
      Autoimmune polyendocrine syndrome type I (APS-I) is a rare, monogenetic recessively inherited disease caused by mutations in the autoimmune regulator (AIRE) gene. The patients display different endocrine and ectodermal ...

    • Autoimmune primary adrenal insufficiency – autoantibodies and cell regeneration 

      Rahman, Md Obaidur (Doctoral thesis, 2024-02-02)
      Autoimmun primær binyrebarksvikt er en sjelden lidelse som skyldes autoimmun ødeleggelse av binyrebarken, og foreløpig finnes det ingen kurativ behandling. Her undersøkte vi to distinkte aspekter ved sykdommen, en molekylær ...

    • Autoimmune Thyroid Disorders in Autoimmune Addison Disease 

      Stokland, Ann-Elin Meling; Ueland, Grethe Åstrøm; Lima, Kari; Grønning, Kaja; Finnes, Trine Elisabeth; Svendsen, Margrethe; Tomkowicz, Aneta Ewa; Holte, Synnøve Emblem; Sollid, Stina Therese; Debowska, Aleksandra; Singsås, Hallvard; Rensvik, Marthe Landsverk; Lejon, Helle; Sørmo, Dag-Erik; Svare, Anders; Blika, Sigrid; Milova, Petya; Korsgaard, Elin; Husby, Øystein; Breivik, Lars Ertesvåg; Jørgensen, Anders Palmstrøm; Husebye, Eystein Sverre (Journal article; Peer reviewed, 2022)
      Context: Autoimmune thyroid disease is the most common endocrine co-morbidity in autoimmune Addison's disease (AAD), but detailed investigations of prevalence and clinical course is lacking. Objective: Provide comprehensive ...

    • Autoimmunity and viral immunity in Addison’s disease 

      Waade Edvardsen, Kine Susann (Doctoral thesis, 2015-11-27)
      Autoimmune Addison’s disease (AAD) is caused by an immunological destruction of the steroid producing cells of the adrenal cortex. Both genetic and environmental factors are involved in disease development, and while ...

    • Autologous stem cells as a promising therapeutic approach for augmentation of alveolar bone 

      Gjerde, Cecilie Gudveig (Doctoral thesis, 2020-08-28)
      The current gold standard for reconstructive bone surgery is based on autologous bone grafts. However, the risk of complications at both the donor and recipient sites is considerable. There is therefore a need to explore ...

    • Automated Quantification and Integrative Analysis of 2D and 3D Mitochondrial Shape and Network Properties 

      Nikolaisen, Julie; Nilsson, Linn Iren Hodneland; Pettersen, Ina Katrine Nitschke; Willems, Peter H. G. M.; Lorens, James B.; Koopman, Werner J. H.; Tronstad, Karl Johan (Peer reviewed; Journal article, 2014-07-02)
      Mitochondrial morphology and function are coupled in healthy cells, during pathological conditions and (adaptation to) endogenous and exogenous stress. In this sense mitochondrial shape can range from small globular ...

    • Automated segmentation of endometrial cancer on MR images using deep learning 

      Hodneland, Erlend; Dybvik, Julie Andrea; Wagner-Larsen, Kari Strøno; Solteszova, Veronika; Zanna, Antonella; Fasmer, Kristine Eldevik; Krakstad, Camilla; Lundervold, Arvid; Lundervold, Alexander Selvikvåg; Salvesen, Øyvind; Erickson, Bradley J.; Haldorsen, Ingfrid S. (Journal article; Peer reviewed, 2021)
      Preoperative MR imaging in endometrial cancer patients provides valuable information on local tumor extent, which routinely guides choice of surgical procedure and adjuvant therapy. Furthermore, whole-volume tumor analyses ...

    • Automated spectrophotometric bicarbonate analysis in duodenal juice compared to the back titration method 

      Erchinger, Friedemann Georg; Engjom, Trond; Gudbrandsen, Oddrun Anita; Tjora, Erling; Gilja, Odd Helge; Dimcevski, Georg Gjorgji (Peer reviewed; Journal article, 2016-02-03)
      Objectives We have recently evaluated a short endoscopic secretin test for exocrine pancreatic function. Bicarbonate concentration in duodenal juice is an important parameter in this test. Measurement of bicarbonate by ...

    • Automated splitting into batches for observational biomedical studies with sequential processing 

      Burger, Bram; Vaudel, Marc; Barsnes, Harald (Journal article; Peer reviewed, 2022)
      Experimental design usually focuses on the setting where treatments and/or other aspects of interest can be manipulated. However, in observational biomedical studies with sequential processing, the set of available samples ...