Browsing Faculty of Medicine by Title
Now showing items 769-788 of 8826
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Biofilm and dental biomaterials
(Peer reviewed; Journal article, 2015-05-26)All treatment involving the use of biomaterials in the body can affect the host in positive or negative ways. The microbiological environment in the oral cavity is affected by the composition and shape of the biomaterials ... -
Biofilm and planktonic lifestyles of Porphyromonas gingivalis and Fusobacterium nucleatum. Proteomic analysis of bacteria grown as planktonic cells, mono- and dual species biofilm, and characterization of the biofilm extracellular polymeric matrix’
(Doctoral thesis, 2018-04-06)Periodontitis is one of the most prevalent infectious diseases affecting humans. Periodontitis leads to the destruction of the dental support tissues, which in the terminal stage causes loss of teeth. Periodontitis is ... -
Bioinformatic analyses of miRNA-mRNA signature during hiPSC differentiation towards insulin-producing cells upon HNF4α mutation
(Journal article; Peer reviewed, 2020)Mutations in the hepatocyte nuclear factor 4α (HNF4α) gene affect prenatal and postnatal pancreas development, being characterized by insulin-producing β-cell dysfunction. Little is known about the cellular and molecular ... -
Bioinformatic and Genetic Association Analysis of MicroRNA Target Sites in One-Carbon Metabolism Genes
(Peer reviewed; Journal article, 2011-07-12)One-carbon metabolism (OCM) is linked to DNA synthesis and methylation, amino acid metabolism and cell proliferation. OCM dysfunction has been associated with increased risk for various diseases, including cancer and neural ... -
Biological Characteristics of Stem-Like Cells in Oral Squamous Cell Carcinoma
(Doctoral thesis, 2013-06-18)It has been shown that many solid malignancies, including oral squamous cell carcinoma (OSCC), contain a small population of tumorigenic cells referred to as cancer stem-like cells (CSCs) or tumor initiating cells (TICs). ... -
The Biological Context of C-Reactive Protein as a Prognostic Marker in Renal Cell Carcinoma: Studies on the Acute Phase Cytokine Profile
(Journal article; Peer reviewed, 2020)High serum levels of the acute phase protein C-reactive protein (CRP) are associated with an adverse prognosis in renal cancer. The acute phase reaction is cytokine-driven and includes a wide range of inflammatory mediators. ... -
Biological markers and cognitive function in painful temporomandibular disorder
(Doctoral thesis, 2023-09-01)Bakgrunn og mål: Smertefull temporomandibulær lidelse (pTMD) er preget av smerte og dysfunksjon i tyggeapparatet og kjeveleddet. Det overordnede målet med denne avhandlingen var å karakterisere en pasientgruppe med ... -
Biological mechanisms for chronic fatigue in primary Sjøgren`s syndrome
(Doctoral thesis, 2012-06-15)Background: Primary Sjøgren`s syndrome (pSS) is a chronic autoimmune disease, characterised by lymphocytic infiltration of exocrine glands and autoantibody production. Fatigue is a frequent phenomenon in pSS, associated ... -
Biological responses of dental pulp cells to surfaces modified by collagen 1 and fibronectin
(Journal article; Peer reviewed, 2020)Collagen 1 (COL1) and fibronectin (FN) are extracellular matrix proteins that contribute in cell activity and involve in regulating dental pulp cells (DPCs). The purpose of this study was to investigate the effect of COL1 ... -
Biological responses of dental pulp stem cells to surfaces modified by collagen 1 and fibronectin
(Master thesis, 2014-01-18)Collagen 1 and fibronectin are extracellular matrix proteins that contribute in cell activity and involve in regulating dental pulp stem cells. The purpose of this in vitro study was to investigate the effect of collagen ... -
Biological Responses to Aliphatic Polyester Scaffolds for Bone Tissue Engineering Applications
(Doctoral thesis, 2010-12-03)Currently, various strategies are used to stimulate healing of bone defects and restore lost alveolar bone and periodontal support. The concept of tissue engineering has emerged as a valid approach to the current therapies ... -
Biological variation of cardiac myosin-binding protein C in healthy individuals
(Journal article; Peer reviewed, 2021)Objectives Cardiac myosin-binding protein C (cMyC) is a novel biomarker of myocardial injury, with a promising role in the triage and risk stratification of patients presenting with acute cardiac disease. In this study, ... -
Biological variation of secretoneurin; a novel cardiovascular biomarker implicated in arrhythmogenesis
(Journal article, 2021)Background Secretoneurin is a novel prognostic biomarker that may predict mortality in heart failure and the occurrence of ventricular arrhythmias. This study reports the within subject variation (CVI), between subject ... -
The biology of aging and cancer: A brief overview of shared and divergent molecular hallmarks
(Peer reviewed; Journal article, 2017-10)Aging is the inevitable time-dependent decline in physiological organ function and is a major risk factor for cancer development. Due to advances in health care, hygiene control and food availability, life expectancy is ... -
Biomarker and pathology studies in neurodegenerative cognitive impairment
(Doctoral thesis, 2019-10-16)Background: Dementia is a major cause of functional impairment and early death in older age groups. Neurodegenerative disorders are the most common cause of dementia. The most frequent neuropathological lesions include ... -
Biomarker changes as surrogate endpoints in early-phase trials in heart failure with reduced ejection fraction
(Journal article; Peer reviewed, 2022)Aims No biomarker has achieved widespread acceptance as a surrogate endpoint for early-phase heart failure (HF) trials. We assessed whether changes over time in a panel of plasma biomarkers were associated with subsequent ... -
Biomarker profiles in serum and saliva of experimental Sjögren's syndrome: associations with specific autoimmune manifestations
(Peer reviewed; Journal article, 2008-02-20)Introduction Sjögren's syndrome (SS) is a systemic autoimmune disease that mainly targets the exocrine glands. The aim of this study was to investigate the involvement of 87 proteins measured in serum and 75 proteins ... -
Biomarker prognostication of cognitive impairment may be feasible even in out-of hospital cardical arrest survivors with good neurological outcome
(Journal article; Peer reviewed, 2021)Background Patients surviving out-of hospital cardicac arrest, with good neurological outcome according to Cerebral Performance Category, frequently have neuropsychological impairment. We studied whether biomarker data ... -
Biomarker signature and pathophysiological pathways in patients with chronic heart failure and metabolic syndrome
(Journal article; Peer reviewed, 2023)Aim The comorbidities that collectively define metabolic syndrome are common in patients with heart failure. However, the role of metabolic syndrome in the pathophysiology of heart failure is not well understood. We ... -
Biomarkers and Algorithms for the Diagnosis of Vitamin B12 Deficiency
(Peer reviewed; Journal article, 2016-06-27)Vitamin B12 (cobalamin, Cbl, B12) is an indispensable water-soluble micronutrient that serves as a coenzyme for cytosolic methionine synthase (MS) and mitochondrial methylmalonyl-CoA mutase (MCM). Deficiency of Cbl, whether ...