Browsing Faculty of Medicine by Subject "Addison's disease"
Now showing items 1-3 of 3
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Glucocorticoid pharmacogenetics in Addison's disease - The role of the immunophilin FK506-binding protein (FKBP51) for glucocorticoid sensitivity
(Master thesis, 2008-05-31)There is great variation in the inter-individual sensitivity to glucocorticoids. The immunophilin FK506 binding protein (FKBP51) confers short-loop negative feedback inhibition of the glucocorticoid signalling pathway. ... -
Multisteroid LC-MS/MS assay for glucocorticoids and androgens, and its application in Addison’s disease
(Peer reviewed; Journal article, 2013)Objective: Liquid chromatography–tandem mass spectrometry (LC–MS/MS) offers superior analytical specificity compared with immunoassays, but it is not available in many regions and hospitals due to expensive instrumentation ... -
The role of autoantibodies in cell mediated autoimmune Addison`s disease
(Master thesis, 2012-05-31)Background: Addison`s disease (primary adrenal insufficiency) is a prototypic organ-specific autoimmune disease affecting the adrenal cortex. Autoimmune Addison`s disease (AAD) is often characterized by autoantibodies ...