Browsing Department of Biomedicine by Title
Now showing items 204-223 of 708
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Effects of blood contamination and the rostro-caudal gradient on the human cerebrospinal fluid proteome
(Peer reviewed; Journal article, 2014-03-05)Over the last years there has been an increased focus on the importance of knowing the effect of pre-analytical influence on the proteomes under study, particularly in the field of biomarker discovery. We present three ... -
Effects of dietary Lactobacillus plantarum and AHL lactonase on the control of Aeromonas hydrophila infection in tilapia
(Peer reviewed; Journal article, 2016-08)This study addressed the effects of dietary Lactobacillus plantarum or/and N-acylated homoserine lactonase (AHL lactonase) on controlling Aeromonas hydrophila infection in juvenile hybrid tilapia (Oreochromis niloticus♀ × ... -
Effects of Frozen Storage on Phospholipid Content in Atlantic Cod Fillets and the Influence on Diet-Induced Obesity in Mice
(Peer reviewed; Journal article, 2018-05-30)A large fraction of the n-3 polyunsaturated fatty acids (PUFAs) in cod fillet is present in the form of phospholipids (PLs). Freezing initiates hydrolysis of the PLs present in the fillet. Here, we compared the effects of ... -
Effects of oil compounds and persistent organic pollutants (POPs) on phospholipid composition in liver and brain of Atlantic cod (Gadus morhua)
(Doctoral thesis, 2012-10-12)The work in this thesis is part of a project led by the Institute of Marine Research (IMR), with partners at the Department of Biomedicine (University of Bergen, UiB), the National Institute of Nutrition and Seafood Research ... -
The effects of phenylalanine and tyrosine levels on dopamine production in rat PC12 cells. Implications for treatment of phenylketonuria, tyrosinemia type 1 and comorbid neurodevelopmental disorders
(Journal article; Peer reviewed, 2023)Phenylketonuria (PKU) is an autosomal recessive metabolic disorder caused by mutations in the phenylalanine hydroxylase (PAH) gene, resulting in phenylalanine accumulation and impaired tyrosine production. In Tyrosinemia ... -
Efficient and crucial quality control of HAP1 cell ploidy status
(Journal article; Peer reviewed, 2020)The near-haploid human cell line HAP1 recently became a popular subject for CRISPR/Cas9 editing, since only one allele requires modification. Through the gene-editing service at Horizon Discovery, there are at present more ... -
An eGFP expressing immunodeficent mouse model with dsRED transfected mammary tumours, and the effect of hyperbaric oxygen treatment
(Master thesis, 2009-11-20)Previous studies have shown significant anti-tumour effects of hyperbaric oxygen (HBO) treatment on chemically induced mammary tumours. Thus, to answer whether HBO has a general anti-tumour effect on mammary tumours, the ... -
Electrical synapses between AII amacrine cells in the retina: Function and modulation
(Peer reviewed; Journal article, 2012)Adaptation enables the visual system to operate across a large range of background light intensities. There is evidence that one component of this adaptation is mediated by modulation of gap junctions functioning as ... -
Electroconvulsive therapy-induced volumetric brain changes converge on a common causal circuit in depression
(Journal article; Peer reviewed, 2023)Neurostimulation is a mainstream treatment option for major depression. Neuromodulation techniques apply repetitive magnetic or electrical stimulation to some neural target but significantly differ in their invasiveness, ... -
An electrophysiological study in freely exploring rats - Place cell properties and place field stability in the absence or presence of reward as a motivational factor.
(Master thesis, 2009-06-02)The activity of pyramidal cells in the hippocampus can be spatially modulated. Numerous studies have been performed examining their properties, like what influences the position of their firing fields or what effect changes ... -
Electrotonic signal processing in AII amacrine cells: compartmental models and passive membrane properties for a gap junction-coupled retinal neuron
(Peer reviewed; Journal article, 2018-09)Amacrine cells are critical for processing of visual signals, but little is known about their electrotonic structure and passive membrane properties. AII amacrine cells are multifunctional interneurons in the mammalian ... -
Elevated body weight modulates subcortical volume change and associated clinical response following electroconvulsive therapy
(Journal article; Peer reviewed, 2021)Background: Obesity is a frequent somatic comorbidity of major depression, and it has been associated with worse clinical outcomes and brain structural abnormalities. Converging evidence suggests that electroconvulsive ... -
Elevated CD3+ and CD8+ tumor-infiltrating immune cells correlate with prolonged survival in glioblastoma patients despite integrated immunosuppressive mechanisms in the tumor microenvironment and at the systemic level
(Peer reviewed; Journal article, 2013-11-15)We characterized GBM patients' tumor and systemic immune contexture with aim to reveal themechanisms of immunological escape, their impact on patient outcome, and identify targets for immunotherapy. Increased CD3+ T-cell ... -
Elucidating tumour-associated microglia/macrophage diversity along glioblastoma progression and under ACOD1 deficiency
(Journal article; Peer reviewed, 2022)In glioblastoma (GBM), tumour-associated microglia/macrophages (TAMs) represent the major cell type of the stromal compartment and contribute to tumour immune escape mechanisms. Thus, targeting TAMs is emerging as a promising ... -
Enhanced cognitive function and antidepressant-like effects after krill oil supplementation in rats
(Peer reviewed; Journal article, 2013-01-25)Background: The purpose of the study was to evaluate the effects of krill oil (KO) on cognition and depression-like behaviour in rats. Methods: Cognition was assessed using the Aversive Light Stimulus Avoidance Test (ALSAT). ... -
Enhanced gene expression from retroviral vectors
(Peer reviewed; Journal article, 2008-02-25)Background: Retroviruses are widely used to transfer genes to mammalian cells efficiently and stably. However, genetic elements required for high-level gene expression are incompatible with standard systems. The retroviral ... -
Enhanced protein synthesis and secretion using a rational signal-peptide library approach as a tailored tool
(Peer reviewed; Journal article, 2011-11-22) -
Epac1 Is Crucial for Maintenance of Endothelial Barrier Function through A Mechanism Partly Independent of Rac1
(Journal article; Peer reviewed, 2020)Epac1 (exchange protein activated by cAMP) stabilizes the endothelial barrier, but detailed studies are limited by the side effects of pharmacological Epac1 modulators and transient transfections. Here, we compare the key ... -
Epac1 null mice have nephrogenic diabetes insipidus with deficient corticopapillary osmotic gradient and weaker collecting duct tight junctions
(Journal article; Peer reviewed, 2020)Aim The cAMP‐mediator Epac1 (RapGef3) has high renal expression. Preliminary observations revealed increased diuresis in Epac1−/− mice. We hypothesized that Epac1 could restrict diuresis by promoting transcellular collecting ... -
Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expression
(Peer reviewed; Journal article, 2017)Epac1 (Exchange protein directly activated by cAMP 1) limits fluid loss from the circulation by tightening the endothelial barrier. We show here that Epac1−/− mice, but not Epac2−/− mice, have prolonged bleeding time, ...