Browsing Department of Biomedicine by Author "Kopperud, Reidun Kristin"

Now showing items 1-7 of 7

    • Activation of Protein Kinase A and Exchange Protein Directly Activated by cAMP Promotes Adipocyte Differentiation of Human Mesenchymal Stem Cells 

      Jia, Bingbing; Madsen, Lise; Petersen, Rasmus Koefoed; Techer, Nathalie; Kopperud, Reidun Kristin; Ma, Tao; Døskeland, Stein Ove; Ailhaud, Gérard; Wang, Jinfu; Amri, Ez-Zoubir; Kristiansen, Karsten (Peer reviewed; Journal article, 2012-03-27)
      Human mesenchymal stem cells are primary multipotent cells capable of differentiating into several cell types including adipocytes when cultured under defined in vitro conditions. In the present study we investigated the ...

    • Androgen receptor as potential therapeutic target in metastatic endometrial cancer 

      Tangen, Ingvild Løberg; Onyango, Therese Bredholt; Kopperud, Reidun Kristin; Berg, Anna; Halle, Mari Kyllesø; Øyan, Anne Margrete; Werner, Henrica Maria Johanna; Trovik, Jone; Kalland, Karl-Henning; Salvesen, Helga Birgitte; Krakstad, Camilla (Peer reviewed; Journal article, 2016-06-30)
      Purpose: The expression and involvement of estrogen (ER) and progesterone receptor (PR) is extensively studied in endometrial cancer. Androgen receptor (AR) is a hormone receptor less studied in female cancers, and we here ...

    • Epac1 null mice have nephrogenic diabetes insipidus with deficient corticopapillary osmotic gradient and weaker collecting duct tight junctions 

      Åsrud, Kathrine Sivertsen; Bjørnstad, Ronja; Kopperud, Reidun Kristin; Pedersen, Line; van der Hoeven, Barbara; Karlsen, Tine Veronica; Rygh, Cecilie Brekke; Curry, Fitz-Roy; Bakke, Marit; Reed, Rolf K.; Tenstad, Olav; Døskeland, Stein Ove (Journal article; Peer reviewed, 2020)
      Aim The cAMP‐mediator Epac1 (RapGef3) has high renal expression. Preliminary observations revealed increased diuresis in Epac1−/− mice. We hypothesized that Epac1 could restrict diuresis by promoting transcellular collecting ...

    • Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expression 

      Nygaard, Gyrid; Herfindal, Lars; Åsrud, Kathrine Sivertsen; Bjørnstad, Ronja; Kopperud, Reidun Kristin; Oveland, Eystein; Berven, Frode; Myhren, Lene Elisabeth; Høivik, Erling Andre; Lunde, Turid Helen Felli; Bakke, Marit; Døskeland, Stein Ove; Selheim, Frode (Peer reviewed; Journal article, 2017)
      Epac1 (Exchange protein directly activated by cAMP 1) limits fluid loss from the circulation by tightening the endothelial barrier. We show here that Epac1−/− mice, but not Epac2−/− mice, have prolonged bleeding time, ...

    • Increased microvascular permeability in mice lacking Epac1 (Rapgef3) 

      Kopperud, Reidun Kristin; Rygh, Cecilie Brekke; Karlsen, Tine Veronica; Krakstad, Camilla; Kleppe, Rune; Høivik, Erling Andre; Bakke, Marit; Tenstad, Olav; Selheim, Frode; Liden, Åsa; Madsen, Lise; Pavlin, Tina; Taxt, Torfinn; Kristiansen, K.; Curry, FE; Reed, Rolf K.; Doskeland, Stein Ove (Peer reviewed; Journal article, 2017-02)
      Aim: Maintenance of the blood and extracellular volume requires tight control of endothelial macromolecule permeability, which is regulated by cAMP signalling. This study probes the role of the cAMP mediators rap guanine ...

    • Introduction of aromatic ring-containing substituents in cyclic nucleotides is associated with inhibition of toxin uptake by the hepatocyte transporters OATP 1B1 and 1B3 

      Herfindal, Lars; Krakstad, Camilla; Myhren, Lene Elisabeth; Hagland, Hanne; Kopperud, Reidun Kristin; Teigen, Knut; Schwede, Frank; Kleppe, Rune; Døskeland, Stein Ove (Peer reviewed; Journal article, 2014-04-16)
      Analogs of the cyclic nucleotides cAMP and cGMP have been extensively used to mimic or modulate cellular events mediated by protein kinase A (PKA), Exchange protein directly activated by cAMP (Epac), or protein kinase G ...

    • Long-term consumption of an obesogenic high fat diet prior to ischemia-reperfusion mediates cardioprotection via Epac1-dependent signaling 

      Edland, Fridtjov; Wergeland, Anita; Kopperud, Reidun Kristin; Åsrud, Kathrine Sivertsen; Hoivik, Erling A; Witsø, Solveig Lund; Æsøy, Reidun; Madsen, L; Kristiansen, K.; Bakke, Marit; Doskeland, Stein Ove; Jonassen, Anne K (Peer reviewed; Journal article, 2016-11-28)
      Background: Obesity is still considered a risk factor for cardiovascular disease, although more recent knowledge also suggests obesity to be associated with reduced morbidity and mortality - the “obesity paradox”. This ...