Blar i Department of Clinical Medicine på utgivelsesdato
Viser treff 1-20 av 2061
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Impact of birth weight on kidney health in middle-aged adults : Results from the Haugesund Low Birth Weight Study
(Doctoral thesis, 2024-06-07)Bakgrunn: Tidligere studier, inkludert flere studier basert på medisinsk fødselsregister i Norge, har vist en sammenheng mellom lav fødselsvekt og redusert nyrefunksjon hos voksne. Studier som bruker målt glomerulær ... -
Molecular mechanisms of mitochondrial dysfunction in neurodegenerative diseases
(Doctoral thesis, 2024-06-05)Bakgrunn Nevrodegenerative lidelser er komplekse lidelser i sentralnervesystemet som er typisk preget av akkumulering av feilfoldede proteiner og progressiv degenerasjon og død av sårbare cellepopulasjoner i de berørte ... -
Improving Outcomes of Antipsychotic Treatment in Schizophrenia
(Doctoral thesis, 2024-05-31)Bakgrunn/Formål: Den farmakologiske behandlingen av schizofreni gir langt fra optimale resultater, i forhold til både positive og negative symptomer. Denne avhandlingen hadde som hensikt å undersøke utfall i form av respons ... -
High-Dose Folic Acid Use during Pregnancy and Cancer Risk in Mothers and Children With Focus on Maternal Epilepsy
(Doctoral thesis, 2024-05-23)Norsk sammendrag: Bakgrunn: Gravide kvinner som tar antianfallsmedikasjon (ASM) anbefales høyere daglige doser av folsyre (>1 mg) enn den generelle befolkningen (0.4–0.8 mg) for å beskytte fosteret. Folsyre, den syntetiske ... -
Quantitative analogues to visual spike interpretation in EEG
(Doctoral thesis, 2024-05-03)Bakgrunn: Noen skarpe transienter i EEG er interiktale epileptiforme utladninger (IEU) og representerer en biomarkør for epilepsi. Visuell analyse er den gjeldende gullstandarden for å detektere IEUer. En slik analyse ... -
Cognitive assessment in the early stages of multiple sclerosis : the importance of screening and management of cognitive impairment
(Doctoral thesis, 2024-04-19)Bakgrunn: Kognitiv svekkelse er et vanlig symptom hos pasienter med multippel sklerose (MS), med potentielt stor innvirkning på livskvalitet, yrkesdeltagelse og sosialt liv. Dette kan oppstå i alle stadier og alle subtyper ... -
Multiple adversity: Childhood abuse, adult abuse, and perinatal depression in women with multiple sclerosis : A register-based cohort study
(Doctoral thesis, 2024-02-23)Bakgrunn: Stress kan spille en rolle ved multippel sklerose (MS). Stress i barndommen forårsaket av vold og overgrep er assosiert med økt risiko for kroniske sykdommer i voksen alder. Det er ukjent om slikt stress kan ... -
Clinical Management of Vestibular Schwannoma : The V-REX randomized trial and other clinical studies on vestibular schwannoma
(Doctoral thesis, 2024-01-20)Introduksjon: Vestibularis schwannomer (VS) er godartede svulster som utgår fra de Schwannske cellene rundt den åttende hjernenerven og utgjør ca. 8% av alle intrakranielle neoplasmer. Behandlingsalternativene er mikrokirurgisk ... -
Novel biomarkers in multiple sclerosis pathology with a focus on neuroprotection and myelin repair
(Doctoral thesis, 2024-01-16)Multippel sklerose (MS) er en sykdom som fører til skade på nervesystemet, kjennetegnet av definerte områder med vevsskade (lesjoner) i sentralnervesystemet (CNS). Dette resulterer i varig funksjonshemming hos pasienter. ... -
Vestibular Symptoms, Balance and Vestibular Function in Patients with Vestibular Schwannoma
(Doctoral thesis, 2024-01-12)Bakgrunn: Vestibularisschwannom (VS) er en godartet svulst på den 8.hjernenerve som ofte fører til hørselstap, øresus, ustøhet og vertigo. Behandling avhenger av svulstens størrelse og om svulsten vokser, og inkluderer ... -
Prevalence, Risk Factors, and Clinical and Biochemical Characteristics of Alemtuzumab-Induced Graves Disease
(Journal article; Peer reviewed, 2024)Objective Atypical Graves disease (GD) is a common complication in multiple sclerosis (MS) patients treated with alemtuzumab. We present epidemiological, clinical, and biochemical characteristics of alemtuzumab-induced ... -
Impaired glucose utilization in the brain of patients with delirium following hip fracture
(Journal article; Peer reviewed, 2024)Alterations in brain energy metabolism have long been proposed as one of several neurobiological processes contributing to delirium. This is supported by previous findings of altered CSF lactate and neuron-specific enolase ... -
The Delta III and Delta Xtend reverse shoulder arthroplasty. Risk of revision and failure mechanisms: a report on 3,650 cases from the Norwegian Arthroplasty Register 1994-2021
(Journal article; Peer reviewed, 2024)Background The Delta reverse shoulder arthroplasty (RSA) is commonly used worldwide and is the most frequently used RSA in Norway. The aim of this registry-based study was to report 10- and 20-year implant survival, ... -
COL11A1 is associated with developmental dysplasia of the hip and secondary osteoarthritis in the HUNT study
(Journal article; Peer reviewed, 2024)Objective: Developmental dysplasia of the hip (DDH) is a congenital condition affecting 2-3% of all infants. DDH increases the risk of osteoarthritis, is the cause of 30% of all total hip arthroplasties (THAs) in adults ... -
TP53 mutation and human papilloma virus status as independent prognostic factors in a Norwegian cohort of vulva squamous cell carcinoma
(Journal article; Peer reviewed, 2024)Introduction: Vulva squamous cell carcinoma (VSCC) develops through two separate molecular pathways—one involving high-risk human papilloma virus infection (HPV-associated), and the other without HPV infection (HPV-independent) ... -
Longer-term quality of care, effectiveness, and cost-effectiveness of implementing a model of care for osteoarthritis: A cluster-randomized controlled trial
(Journal article; Peer reviewed, 2024)Objective: To assess the quality of care, effectiveness, and cost-effectiveness over 12 months after implementing a structured model of care for hip and knee osteoarthritis (OA) in primary healthcare as compared to usual ... -
Potential of AI-Driven Chatbots in Urology: Revolutionizing Patient Care Through Artificial Intelligence
(Journal article; Peer reviewed, 2024)Purpose of Review Artificial intelligence (AI) chatbots have emerged as a potential tool to transform urology by improving patient care and physician efficiency. With an emphasis on their potential advantages and ... -
Transitioning from transrectal to transperineal prostate biopsy using a freehand cognitive approach
(Journal article; Peer reviewed, 2024)Objectives To report a single-centre experience of a complete transition from transrectal (TR) to transperineal (TP) prostate biopsy under local anaesthesia using a freehand cognitive coaxial approach and without use ... -
Prescribing patterns for higher dose folic acid in pregnant women with epilepsy treated with antiseizure medication
(Journal article; Peer reviewed, 2024)Objective: This study was undertaken to characterize the use of higher doses of folic acid (≥1 mg daily) in relation to pregnancy in Denmark, Norway, and Sweden in women with epilepsy treated with antiseizure medication ... -
The Association of Isocaloric Subtitution of Dietary Protein in Middle Age with Muscle Mass and Strength in Old Age: The Hordaland Health Study
(Journal article; Peer reviewed, 2024)Background Age-associated loss of muscle mass and strength is an important predictor of disability in older persons. Although several mechanisms contribute to the decline in muscle mass and function seen with aging, the ...