Blar i Bergen Open Research Archive på tittel
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Functional analysis of BRCA1 variants of uncertain significance (VUS)
(Master thesis, 2022-06-01) -
Functional analysis of metagenomes and metatranscriptomes using SEED and KEGG
(Peer reviewed; Journal article, 2011-02-15)Background: Metagenomics is the study of microbial organisms using sequencing applied directly to environmental samples. Technological advances in next-generation sequencing methods are fueling a rapid increase in the ... -
Functional analysis of the nonvisual opsins melanopsin and vertebrate ancient opsin (VA opsin) in Atlantic salmon (Salmo salar)
(Master thesis, 2017-06-15)The role of nonvisual photoreceptors is yet to be elucidated regarding the link to biological function. This study aims to characterise the expression pattern of melanopsin and vertebrate ancient opsin during early ... -
Functional analysis of tilS homologues in Bacteria and Archaea
(Master thesis, 2005-09-09)Out of all of the microorganisms sequenced so far about one third of the genes have unknown function. Several studies have shown that information on evolutionary relationships between unknown genes can aid in the prediction ... -
Functional and animal studies of short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD), a fatty acid beta-oxidation enzyme involved in congenital hyperinsulinism of infancy
(Doctoral thesis, 2021-02-16)Short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD) is a mitochondrial enzyme involved in fatty acid β-oxidation and the regulation of β-cell insulin secretion. Its role in insulin secretion became apparent in 2001 when ... -
Functional and Binding H1N1pdm09-Specific Antibody Responses in Occasionally and Repeatedly Vaccinated Healthcare Workers: A Five-Year Study (2009-2014)
(Journal article; Peer reviewed, 2021)Background: In 2009, a novel influenza A/H1N1pdm09 emerged and caused a pandemic. This strain continued to circulate and was therefore included in the seasonal vaccines up to the 2016/2017-season. This provided a unique ... -
Functional and molecular characterisation of a unique double homozygous variant causing ABCA4-related retinopathy
(Master thesis, 2023-06-02) -
Functional and Prognostic Role of MicroRNAs in Cancer Associated Fibroblasts and Stroma in Oral Squamous Cell Carcinoma
(Doctoral thesis, 2023-11-23)Nyere studier har vist at forandringer i bindevevscellene som omgir kreftsvulsten er viktige for utviklingen av munnhulekreft. Kreft stroma kan regulere fenotypen av kreftcellene, og på den måten kan påvirke klinisk forløpet ... -
The functional and structural asymmetries of the superior temporal sulcus
(Peer reviewed; Journal article, 2018-02)The superior temporal sulcus (STS) is an anatomical structure that increasingly interests researchers. This structure appears to receive multisensory input and is involved in several perceptual and cognitive core functions, ... -
Functional annotation of human long noncoding RNAs via molecular phenotyping
(Journal article; Peer reviewed, 2020)Long noncoding RNAs (lncRNAs) constitute the majority of transcripts in the mammalian genomes, and yet, their functions remain largely unknown. As part of the FANTOM6 project, we systematically knocked down the expression ... -
Functional assessment of 3'UTR regulatory elements using the zebrafish (Danio rerio) model system - towards modulating protein levels in Atlantic salmon (Salmo salar) for more sustainable aquaculture
(Master thesis, 2021-11-22)Post-transcriptional regulation is a complex process that encompasses a myriad of different structures and mechanisms. There are several indications that regulatory elements in the 3'UTR play an important role in the ... -
Functional asymmetry and effective connectivity of the auditory system during speech perception is modulated by the place of articulation of the consonant – A 7 T fMRI study
(Peer reviewed; Journal article, 2014-06-11)To differentiate between stop-consonants, the auditory system has to detect subtle place of articulation (PoA) and voice-onset time (VOT) differences between stop-consonants. How this differential processing is represented ... -
Functional brain networks in the schizophrenia spectrum and bipolar disorder with psychosis
(Journal article; Peer reviewed, 2020)Psychotic experiences have been proposed to lie on a spectrum, ranging from subclinical experiences to treatment-resistant schizophrenia. We aimed to characterize functional connectivity and brain network characteristics ... -
Functional changes in GABA and glutamate during motor learning
(Journal article; Peer reviewed, 2023)Functional magnetic resonance spectroscopy (fMRS) of GABA at 3 T poses additional challenges compared with fMRS of other metabolites because of the difficulties of measuring GABA levels; GABA is present in the brain at ... -
Functional characterisation of polybasic motifs in the nucleolar PtdIns(3,4,5)P3- interacting proteins proliferation-associated protein 2G4 and poly(ADP-ribose) polymerase 1
(Doctoral thesis, 2023-06-13)Fosfoinositid 3-kinase (PI3K)-signalveien er viktig for flere cellulære prosesser, inklusiv celleoverlevelse, proliferasjon og proteinsyntese. Den er godt beskrevet i cytoplasmaet. I tillegg kan fosfatidylinositol ... -
Functional characterisation of three human nicotinamide mononucleotide adenylyltransferases
(Doctoral thesis, 2008-08-25)Nicotinamide adenine dinucleotide, NAD, is an essential redox factor in many, primarily catabolic, hydrogen transfer reactions. While the redox reactions are not accompanied by a net loss of the pyridine nucleotides, NAD+ ... -
Functional characterization of all-trans retinoic acid-induced differentiation factor (ATRAID)
(Journal article; Peer reviewed, 2023)All-trans retinoic acid-induced differentiation (ATRAID) factor was first identified in HL60 cells. Several mRNA isoforms exist, but the respective proteins have not been fully characterized. In transfected cells expressing ... -
Functional characterization of Atlantic salmon (Salmo salar L.) PepT2 transporters
(Journal article; Peer reviewed, 2022)The high-affinity/low-capacity system Slc15a2 (PepT2) is responsible for the reuptake of di/tripeptides from the renal proximal tubule, but it also operates in many other tissues and organs. Information regarding PepT2 in ... -
Functional characterization of Carboxyl Ester Lipase variants causing diabetes and exocrine dysfunction
(Master thesis, 2016-11-21)The digestive enzyme carboxyl ester lipase (CEL) is mainly expressed in the acinar cells of the pancreas. We have previously identified disease-causing mutations in a variable number of tandem repeats (VNTR) domain, localised ... -
Functional characterization of ErbB3-binding protein 1 (EBP1) tumor mutants
(Master thesis, 2021-06-15)Four C-terminal EBP1 mutants, Q367H, Q367K, K373E-Ins K372R-Del, discovered in various cancer tumors werer investigated by PipStrip assay, whre Q367K had increased binding. Thermal denaturation and immonostaing localization.