Blar i Bergen Open Research Archive på tittel
Viser treff 14598-14617 av 34385
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Identification of a Blood-Based Protein Biomarker Panel for Lung Cancer Detection
(Journal article; Peer reviewed, 2020)Lung cancer is the deadliest cancer worldwide, mainly due to its advanced stage at the time of diagnosis. A non-invasive method for its early detection remains mandatory to improve patients’ survival. Plasma levels of 351 ... -
Identification of a core EMT signature that separates basal-like breast cancers into partial- and post-EMT subtypes
(Journal article; Peer reviewed, 2023)Epithelial-mesenchymal transition (EMT) is a cellular plasticity program critical for embryonic development and tissue regeneration, and aberrant EMT is associated with disease including cancer. The high degree of plasticity ... -
Identification of a nonlinear parameter in a parabolic equation by a linear approach
(Department of Applied Mathematics report, Research report, 1993-03) -
Identification of a novel polymorphism associated with reduced clozapine concentration in schizophrenia patients—a genome-wide association study adjusting for smoking habits
(Journal article; Peer reviewed, 2020)Clozapine (CLZ) is the superior antipsychotic drug for treatment of schizophrenia, but exhibits an extensive interpatient pharmacokinetic variability. Here, we conducted a genome-wide association study (GWAS) of CLZ serum ... -
Identification of a Phage Display-Derived Peptide Interacting with the N-Terminal Region of Factor VII Activating Protease (FSAP) Enables Characterization of Zymogen Activation
(Journal article; Peer reviewed, 2022)Factor VII Activating protease (FSAP) has a protective effect in diverse disease conditions as inferred from studies in FSAP–/– mice and humans deficient in FSAP activity due to single-nucleotide polymorphism. The zymogen ... -
Identification of a potential allosteric site of Golgi α-mannosidase II using computer-aided drug design
(Peer reviewed; Journal article, 2019-05-08)Golgi α-mannosidase II (GMII) is a glycoside hydrolase playing a crucial role in the N-glycosylation pathway. In various tumour cell lines, the distribution of N-linked sugars on the cell surface is modified and correlates ... -
Identification of acute coronary syndrome in the era of high-sensitivity troponin assays
(Doctoral thesis, 2023-06-02)Bakgrunn: Det er mulig å bedre pasientflyt og diagnostisk presisjon ved utredning av pasienter med mistenkt akutt koronarsyndrom (AKS). Konsentrasjonen av kardialt troponin (cTnT eller cTnI) kan benyttes til å forutse ... -
Identification of biomarkers for glycaemic deterioration in type 2 diabetes
(Journal article; Peer reviewed, 2023)We identify biomarkers for disease progression in three type 2 diabetes cohorts encompassing 2,973 individuals across three molecular classes, metabolites, lipids and proteins. Homocitrulline, isoleucine and 2-aminoadipic ... -
Identification of boosted Higgs bosons decaying into b-quark pairs with the ATLAS detector at 13 TeV
(Peer reviewed; Journal article, 2019)This paper describes a study of techniques for identifying Higgs bosons at high transverse momenta decaying into bottom-quark pairs, H→bb¯, for proton–proton collision data collected by the ATLAS detector at the Large ... -
Identification of BST2 Contributing to the Development of Glioblastoma Based on Bioinformatics Analysis
(Journal article; Peer reviewed, 2022)Rigorous molecular analysis of the immune cell environment and immune response of human tumors has led to immune checkpoint inhibitors as one of the most promising strategies for the treatment of human cancer. However, in ... -
Identification of critical enzymes in the salmon louse chitin synthesis pathway as revealed by RNA interference-mediated abrogation of infectivity
(Journal article; Peer reviewed, 2020)Treatment of infestation by the ectoparasite Lepeophtheirus salmonis relies on a small number of chemotherapeutant treatments that currently meet with limited success. Drugs targeting chitin synthesis have been largely ... -
Identification of Cumin (Cuminum cyminum) MicroRNAs through Deep Sequencing and Their Impact on Plant Secondary Metabolism
(Journal article; Peer reviewed, 2023-04-25)The pharmacological properties of plants lie in the content of secondary metabolites that are classified into different categories based on their biosynthesis, structures, and functions. MicroRNAs (miRNAs) are small ... -
Identification of diagnostic and prognostic biomarkers of PD using a multiplex proteomics approach
(Journal article; Peer reviewed, 2023)Given the complexity of Parkinson's disease (PD), achieving acceptable diagnostic and prognostic accuracy will require the support of a panel of diverse biomarkers. We used Proximity extension assays to measure a panel of ... -
Identification of diarrheagenic Escherichia coli isolated from infants and children in Dar es Salaam, Tanzania
(Peer reviewed; Journal article, 2007-08-09)Background: Relatively few studies have been done in Tanzania to detect and classify diarrheagenic Escherichia coli (DEC) strains among children with diarrhea. This study aimed at investigating DEC among children in Dar ... -
Identification of DNA methylation changes in newborns related to maternal smoking during pregnancy
(Peer reviewed; Journal article, 2014-10-01)Background: Maternal smoking during pregnancy is associated with significant infant morbidity and mortality, and may influence later disease risk. One mechanism by which smoking (and other environmental factors) might have ... -
Identification of Dynamic Changes in Proteins Associated with the Cellular Cytoskeleton after Exposure to Okadaic Acid
(Peer reviewed; Journal article, 2013)Exposure of cells to the diarrhetic shellfish poison, okadaic acid, leads to a dramatic reorganization of cytoskeletal architecture and loss of cell-cell contact. When cells are exposed to high concentrations of okadaic ... -
Identification of Epigenetic Modifications Following Treatment with Olanzapine
(Master thesis, 2018-12-19)No chronic disease burdens the world more than psychiatric disorders (Collins et al., 2011), with an estimated 40% of the population in 30 European countries affected in any given year (Insel et al., 2012). Current medical ... -
Identification of gait domains and key gait variables following hip fracture
(Peer reviewed; Journal article, 2015-11-18)Background Restoration of gait is an important goal of rehabilitation after hip fracture. Numerous spatial and temporal gait variables have been reported in the literature, but beyond gait speed, there is little agreement ... -
Identification of Genetic Loci Shared Between Attention-Deficit/Hyperactivity Disorder, Intelligence, and Educational Attainment
(Peer reviewed; Journal article, 2020)Background: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that is consistently associated with lower levels of educational attainment. A recent large genome-wide association study identified ... -
Identification of genetic loci shared between schizophrenia and the Big Five personality traits
(Peer reviewed; Journal article, 2017-05-22)Schizophrenia is associated with differences in personality traits, and recent studies suggest that personality traits and schizophrenia share a genetic basis. Here we aimed to identify specific genetic loci shared between ...