• Early empirical antibiotics and adverse clinical outcomes in infants born very preterm: A population-based cohort 

      Vatne, Anlaug; Hapnes, Nina; Stensvold, Hans Jørgen; Dalen, Ingvild; Guthe, Hans Jørgen Timm; Støen, Ragnhild; Brigtsen, Anne Karin; Rønnestad, Arild Erland; Klingenberg, Claus Andreas (Journal article; Peer reviewed, 2022)
      Objective: The objective of this study was to evaluate the association between empirical antibiotic therapy in the first postnatal week in uninfected infants born very preterm and the risk of adverse outcomes until ...
    • Early evolution of radial glial cells in Bilateria 

      Helm, Conrad; Karl, Anett; Beckers, Patrick; Kaul-Strehlow, Sabrina; Ulbricht, Elke; Kourtesis, Ioannis; Kuhrt, Heidrun; Hausen, Harald; Bartolomaeus, Thomas; Reichenbach, Andreas; Bleidorn, Christoph (Journal article; Peer reviewed, 2017)
      Bilaterians usually possess a central nervous system, composed of neurons and supportive cells called glial cells. Whereas neuronal cells are highly comparable in all these animals, glial cells apparently differ, and in ...
    • Early Evolutionary Selection of NAD Biosynthesis Pathway in Bacteria 

      Sharma, Suraj; Hsieh, Yin-Chen; Dietze, Jørn; Bockwoldt, Mathias; Strømland, Øyvind; Ziegler, Mathias; Heiland, Ines (Journal article; Peer reviewed, 2022)
      Bacteria use two alternative pathways to synthesize nicotinamide adenine dinucleotide (NAD) from nicotinamide (Nam). A short, two-step route proceeds through nicotinamide mononucleotide (NMN) formation, whereas the other ...
    • Early Forms of α-Synuclein Pathology Are Associated with Neuronal Complex I Deficiency in the Substantia Nigra of Individuals with Parkinson’s Disease 

      Flønes, Irene Hana; Nyland, Harald Inge; Sandnes, Dagny Ann; Alves, Guido Werner; Tysnes, Ole-Bjørn; Tzoulis, Charalampos (Journal article; Peer reviewed, 2022)
      Idiopathic Parkinson’s disease (iPD) is characterized by degeneration of the dopaminergic substantia nigra pars compacta (SNc), typically in the presence of Lewy pathology (LP) and mitochondrial respiratory complex I (CI) ...
    • Early Gut Fungal and Bacterial Microbiota and Childhood Growth 

      Schei, Kasper; Simpson, Melanie Rae; Avershina, Ekaterina; Rudi, Knut; Øien, Torbjørn; Juliusson, Petur Benedikt; Underhill, David; Salamati, Saideh; Ødegård, Rønnaug (Journal article; Peer reviewed, 2020)
      Introduction: Childhood growth is a sensitive marker of health. Animal studies show increased height and weight velocity in the presence of fungal as well as antibiotic supplement in feed. Human studies on early gut ...
    • Early Holocene Temperature Oscillations Exceed Amplitude of Observed and Projected Warming in Svalbard Lakes 

      Bilt, Willem van der; D'Andrea, William J.; Werner, Johannes; Bakke, Jostein (Journal article; Peer reviewed, 2019)
      Arctic climate is uniquely sensitive to ongoing warming. The feedbacks that drive this amplified response remain insufficiently quantified and misrepresented in model scenarios of future warming. Comparison with paleotemperature ...
    • Early human impacts and ecosystem reorganization in southern-central Africa 

      Thompson, Jessica; Wright, David K.; Ivory, Sarah J; Choi, Jeong-Heon; Nightingale, Sheila; Mackay, Alex; Schilt, Flora; Otarola-Castillo, Erik; Mercader, Julio; Forman, Steven L.; Pietsch, Timothy; Cohen, Andrew S.; Arrowsmith, J. Ramon; Welling, Menno; Davis, Jacob; Schiery, Benjamin; Kaliba, Potiphar; Malijani, Oris; Blome, Margaret W.; O'Driscoll, Corey A.; Mentzer, Susan M.; Miller, Christopher E.; Heo, Seoyoung; Choi, Jungyu; Tembo, Joseph; Mapemba, Fredrick; Simengwa, Davie; Gomani-Chindebvu, Elizabeth (Journal article; Peer reviewed, 2021-05-05)
      Modern Homo sapiens engage in substantial ecosystem modification, but it is difficult to detect the origins or early consequences of these behaviors. Archaeological, geochronological, geomorphological, and paleoenvironmental ...
    • Early identification of treatment non-response in first-episode psychosis 

      Wold, Kristin Fjelnseth; Ottesen, Akiah; Flaaten, Camilla Bärthel; Johnsen, Erik; Lagerberg, Trine Vik; Romm, Kristin Lie; Simonsen, Carmen; Ueland, Torill; Widing, Line Hustad; Åsbø, Gina; Melle, Ingrid (Journal article; Peer reviewed, 2023)
      Background Approximately one-third of patients with psychotic disorders does not respond to standard antipsychotic treatments. Consensus criteria for treatment resistance (TR) may aid the identification of non-response ...
    • Early indicators of disease progression in Fabry disease that may indicate the need for disease-specific treatment initiation: Findings from the opinion-based PREDICT-FD modified Delphi consensus initiative 

      Hughes, Derralynn A.; Aguiar, Patricio; Deegan, Patrick B; Ezgu, Fatih; Frustaci, Andrea; Lidove, Olivier; Linhart, Aleš; Lubanda, Jean-Claude; Moon, James C; Nicholls, Kathleen; Niu, Dau-Ming; Nowak, Albina; Ramaswami, Uma; Reisin, Ricardo; Rozenfeld, Paula; Schiffmann, Raphael; Svarstad, Einar; Thomas, Mark; Torra, Roser; Vujkovac, Bojan; Warnock, David G.; West, Michael L; Johnson, Jack; Rolfe, Mark J; Feriozzi, Sandro (Journal article; Peer reviewed, 2020)
      Objectives The PRoposing Early Disease Indicators for Clinical Tracking in Fabry Disease (PREDICT-FD) initiative aimed to reach consensus among a panel of global experts on early indicators of disease progression that may ...
    • Early Induction of Cross-Reactive CD8+ T-Cell Responses in Tonsils After Live-Attenuated Influenza Vaccination in Children 

      Mohn, Kristin Greve-Isdahl; Brokstad, Karl Albert; Islam, Shahinul; Oftung, Fredrik; Tøndel, Camilla; Aarstad, Hans Jørgen; Cox, Rebecca Jane (Journal article; Peer reviewed, 2020)
      Background Live-attenuated influenza vaccine (LAIV) was licensed for prophylaxis of children 2–17 years old in Europe in 2012 and is administered as a nasal spray. Live-attenuated influenza vaccine induces both mucosal ...
    • Early infant feeding practices in three African countries: the PROMISE-EBF trial promoting exclusive breastfeeding by peer counsellors 

      Engebretsen, Ingunn Marie S.; Nankabirwa, Victoria; Doherty, Tanya Mark; Diallo, Abdoulaye Hama; Nankunda, Jolly; Fadnes, Lars Thore; Ekström, Eva-Charlotte; Ramokolo, Vundli; Meda, Nicolas; Sommerfelt, Halvor; Jackson, Debra; Tylleskär, Thorkild; Tumwine, James K.; For the PROMISE-EBF study group (Peer reviewed; Journal article, 2014-11-18)
      Background: Immediate and exclusive initiation of breastfeeding after delivery has been associated with better neonatal survival and child health and are recommended by the WHO. We report its impact on early infant feeding ...
    • Early interruption of exclusive breastfeeding: results from the eight-country MAL-ED study 

      Patil, Crystal L.; Turab, Ali; Ambikapathi, Ramya; Nesamvuni, Cebisa; Chandyo, Ram K.; Bose, Anuradha; Islam, M. Munirul; Ahmed, A. M. Shamsir; Olortegui, Maribel Paredes; de Moraes, Milena Lima; Caulfield, Laura E. (Peer reviewed; Journal article, 2015-05-01)
      We report the infant feeding experiences in the first month of life for 2,053 infants participating in “Malnutrition and Enteric Infections: Consequences for Child Health and Development” (MAL-ED). Eight sites (in Bangladesh, ...
    • Early life child micronutrient status, maternal reasoning, and a nurturing household environment have persistent influences on child cognitive development at age 5 years: Results from MAL-ED 

      McCormick, Benjamin J.J.; Richard, Stephanie A.; Caulfield, Laura E.; Pendergast, Laura L.; Seidman, Jessica C.; Koshy, Beena; Roshan, Reeba; Shrestha, Rita; Svensen, Erling; Blacy, Ladislaus; Rasmussen, Zeba; Maphula, Angelina; Scharf, Rebecca; Nahar, Baitun; Haque, Sayma; Rasheed, Muneera; Oria, Reinaldo; Rogawski, Elizabeth T.; Murray-Kolb, Laura E. (Peer reviewed; Journal article, 2019)
      Background: Child cognitive development is influenced by early-life insults and protective factors. To what extent these factors have a long-term legacy on child development and hence fulfillment of cognitive potential is ...
    • The early life condition: Importance for sleep, circadian rhythmicity, behaviour and response to later life challenges 

      Mrdalj, Jelena (Doctoral thesis, 2014-12-09)
      Early life environment has a vast impact on development and adult functioning. Optimal brain development depends not only on genetic programming but also on specific external stimuli, where mother-infant relationships play ...
    • Early life course factors, early childhood caries and oral health related quality of life among five-year-olds – a prospective and intergenerational study from eastern Uganda 

      Birungi, Nancy (Doctoral thesis, 2016-11-11)
      Background: The Early childhood caries, ECC, literature considering children in low income countries is limited to a few cross-sectional studies. Longitudinal studies using causal diagrams (DAGs) with intergenerational ...
    • Early life environment and snoring in adulthood 

      Franklin, Karl A.; Janson, Christer; Gíslason, Thórarinn; Gulsvik, Amund; Gunnbjörnsdottir, Maria; Lærum, Birger Norderud; Lindberg, Eva; Norrman, Eva; Nyström, Lennarth; Omenaas, Ernst; Torén, Kjell; Svanes, Cecilie (Peer reviewed; Journal article, 2008-08-22)
      Background: To our knowledge, no studies of the possible association of early life environment with snoring in adulthood have been published. We aimed to investigate whether early life environment is associated with snoring ...
    • Early life exposures contributing to accelerated lung function decline in adulthood – a follow-up study of 11,000 adults from the general population 

      Kirkeleit, Jorunn; Riise, Trond; Wielscher, Mathias; Accordini, Simone; Carsin, Anne-Elie; Dratva, Julie; Franklin, Karl A.; Garcia-Aymerich, Judith; Jarvis, Deborah; Leynaert, Benedicte; Lodge, Caroline J.; Gomez Real, Francisco; Schlünssen, Vivi; Corsico, Angelo Guido; Heinrich, Joachim; Holm, Matthias; Janson, Christer; Benediktsdóttir, Bryndís; Jogi, Rain; Dharmage, Shyamali C.; Jarvelin, Marjo-Riitta; Svanes, Cecilie (Journal article; Peer reviewed, 2023)
      Background We aimed to assess whether exposure to risk factors in early life from conception to puberty continue to contribute to lung function decline later in life by using a pooled cohort comprising approx. 11,000 adults ...
    • Early life factors in relation to cardiovacular disease in old age in Bergen: a Norwegian retrospective cohort study based on the Hordaland Study (HUSK) 

      Skogen, Jens Christoffer; Stewart, Robert; Knapstad, Marit; Øverland, Simon Nygaard; Mykletun, Arnstein (Peer reviewed; Journal article, 2014-07)
      Objectives: The fetal origins of adult disease hypothesis describes associations found for fetal or early-life expos- ures with cardiovascular risk and disease in adulthood. The extension or not of these associations into ...
    • Early life growth and associations with lung function and bronchial hyperresponsiveness at 11-years of age 

      Mikalsen, Ingvild Bruun; Halvorsen, Thomas; Juliusson, Pétur Benedikt; Magnus, Maria Christine; Nystad, Wenche; Stensrud, Trine; Størdal, Ketil; Vollsæter, Maria; Øymar, Knut Asbjørn Alexander (Journal article; Peer reviewed, 2021)
      Low birthweight and being born small-for-gestational age (SGA) are linked to asthma and impaired lung function. Particularly, poor intrauterine growth followed by rapid catch-up growth during childhood may predispose for ...
    • Early life growth is affecting timing of spawning in the semelparous Barents Sea capelin (Mallotus villosus) 

      Berg, Florian; Shirajee, Samina; Folkvord, Arild; Godiksen, Jane Aanestad; Skaret, Georg; Slotte, Aril (Journal article; Peer reviewed, 2021)
      Capelin (Mallotus villosus) is a forage fish and a key species in the Barents Sea (BS). The BS capelin are semelparous and hence only spawn once along the north coasts of Norway and Russia before they die. The age at ...