Blar i Bergen Open Research Archive på tittel

Viser treff 12972-12991 av 35892

    • A genome-wide association study provides insights into the genetic etiology of 57 essential and non-essential trace elements in humans 

      Moksnes, Marta Riise; Hansen, Ailin Falkmo; Wolford, Brooke; Thomas, Laurent Francois; Rasheed, Humaira; Simic, Anica; Bhatta, Laxmi; Brantsæter, Anne Lise; Surakka, Ida; Zhou, Wei; Magnus, Per Minor; Njølstad, Pål Rasmus; Andreassen, Ole; Syversen, Tore; Zheng, Jie; Fritsche, Lars; Evans, David M.; Warrington, Nicole Maree; Nøst, Therese Haugdahl; Åsvold, Bjørn Olav; Flaten, Trond Peder; Willer, Cristen J.; Hveem, Kristian; Brumpton, Ben Michael (Journal article; Peer reviewed, 2024)
      Trace elements are important for human health but may exert toxic or adverse effects. Mechanisms of uptake, distribution, metabolism, and excretion are partly under genetic control but have not yet been extensively mapped. ...

    • Genome-wide association study reveals dynamic role of genetic variation in infant and early childhood growth 

      Helgeland, Øyvind; Vaudel, Marc; Juliusson, Petur Benedikt; Holmen, Oddgeir Lingaas; Juodakis, Julius; Bacelis, Jonas; Jacobsson, Bo; Lindekleiv, Haakon; Hveem, Kristian; Lie, Rolv T.; Knudsen, Gun Peggy Strømstad; Stoltenberg, Camilla; Magnus, Per; Sagen, Jørn V.; Molven, Anders; Johansson, Stefan; Njølstad, Pål Rasmus (Peer reviewed; Journal article, 2019-10-01)
      Infant and childhood growth are dynamic processes with large changes in BMI during development. By performing genome-wide association studies of BMI at 12 time points from birth to eight years (9286 children, 74,105 ...

    • Genome-wide copy number variation (CNV) in patients with autoimmune Addison’s disease 

      Brønstad, Ingeborg; Wolff, Anette S. B.; Løvås, Kristian; Knappskog, Per; Husebye, Eystein Sverre (Peer reviewed; Journal article, 2011-08-18)
      Background: Addison’s disease (AD) is caused by an autoimmune destruction of the adrenal cortex. The pathogenesis is multi-factorial, involving genetic components and hitherto unknown environmental factors. The aim of the ...

    • Genome-wide DNA methylation profiling of non-small cell lung carcinomas 

      Carvalho, Rejane Hughes; Haberle, Vanja; Hou, Jun; van Gent, Teus; Thongjuea, Supat; van Ijcken, Wilfred F.J.; Kockx, Christel; Brouwer, Rutger; Rijkers, Erikjan; Sieuwerts, Anieta; Foekens, John; van Vroonhoven, Mirjam; Aerts, Joachim; Grosveld, Frank; Lenhard, Boris; Philipsen, Sjaak (Peer reviewed; Journal article, 2012-06-22)
      Background: Non-small cell lung carcinoma (NSCLC) is a complex malignancy that owing to its heterogeneity and poor prognosis poses many challenges to diagnosis, prognosis and patient treatment. DNA methylation is an important ...

    • The genome-wide dynamics of the binding of Ldb1 complexes during erythroid differentiation 

      Soler, Eric; Andrieu-Soler, Charlotte; Boer, Ernie de; Bryne, Jan Christian; Thongjuea, Supat; Stadhouders, Ralph; Palstra, Robert-Jan; Stevens, Mary; Kockx, Christel; IJcken, Wilfred van; Hou, Jun; Steinhoff, Christine; Rijkers, Erikjan; Lenhard, Boris; Grosveld, Frank (Peer reviewed; Journal article, 2010)
      One of the complexes formed by the hematopoietic transcription factor Gata1 is a complex with the Ldb1 (LIM domain-binding protein 1) and Tal1 proteins. It is known to be important for the development and differentiation ...

    • Genome-wide histone acetylation analysis reveals altered transcriptional regulation in the Parkinson’s disease brain 

      Toker, Lilah; Tran, Gia T.; Sundaresan, Janani; Tysnes, Ole-Bjørn; Alves, Guido; Haugarvoll, Kristoffer; Nido, Gonzalo S.; Dölle, Christian; Tzoulis, Charalampos (Journal article; Peer reviewed, 2021)
      Background: Parkinson’s disease (PD) is a complex, age-related neurodegenerative disorder of largely unknown etiology. PD is strongly associated with mitochondrial respiratory dysfunction, which can lead to epigenetic ...

    • Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers 

      Jansen, Iris E.; van der Lee, Sven J.; Gomez-Fonseca, Duber; de Rojas, Itziar; Dalmasso, Maria Carolina; Grenier-Boley, Benjamin; Athanasiu, Lavinia; Bahrami, Shahram; Bergh, Sverre; Djurovic, Srdjan; Fladby, Tormod; Jarholm, Jonas Alexander; Knapskog, Anne Brita; Pålhaugen, Lene; Saltvedt, Ingvild; Selbæk, Geir; Selnes, Per; Andreassen, Ole; Shadrin, Alexey; Skoog, Ingmar; Soininen, Hilkka; Tsolaki, Magda; Van Broeckhoven, Christine; Van Dongen, Jasper; van Swieten, John C.; Vandenberghe, Rik; Vidal, Jean-Sébastien; Visser, Pieter J.; Vogelgsang, Jonathan; Waern, Margda; Wagner, Michael; Wiltfang, Jens; Wittens, Mandy M.J.; Zetterberg, Henrik; Zulaica, Miren; van Duijn, Cornelia M.; Bjerke, Maria; Engelborghs, Sebastiaan; Jessen, Frank; Teunissen, Charlotte E.; Pastor, Pau; Hiltunen, Mikko; Ingelsson, Martin; Clarimón, Jordi; Sleegers, Kristel; Ruiz, Agustín; Ramirez, Alfredo; Cruchaga, Carlos; Lambert, Jean-Charles; van der Flier, Wiesje M. (Journal article; Peer reviewed, 2022)
      Amyloid-beta 42 (Aβ42) and phosphorylated tau (pTau) levels in cerebrospinal fluid (CSF) reflect core features of the pathogenesis of Alzheimer’s disease (AD) more directly than clinical diagnosis. Initiated by the European ...

    • A genome-wide scan of cleft lip triads identifies parent-of-origin interaction effects between ANK3 and maternal smoking, and between ARHGEF10 and alcohol consumption 

      Haaland, Øystein Ariansen; Romanowska, Julia; Gjerdevik, Miriam; Lie, Rolv T.; Gjessing, Håkon K.; Jugessur, Astanand (Journal article; Peer reviewed, 2019-06-24)
      Background: Although both genetic and environmental factors have been reported to influence the risk of isolated cleft lip with or without cleft palate (CL/P), the exact mechanisms behind CL/P are still largely unaccounted ...

    • A genome-wide search for gene-environment effects in isolated cleft lip with or without cleft palate triads points to an interaction between maternal periconceptional vitamin use and variants in ESRRG 

      Haaland, Øystein Ariansen; Lie, Rolv T.; Romanowska, Julia; Gjerdevik, Miriam; Gjessing, Håkon K.; Jugessur, Astanand (Peer reviewed; Journal article, 2018-02-26)
      Background: It is widely accepted that cleft lip with or without cleft palate (CL/P) results from the complex interplay between multiple genetic and environmental factors. However, a robust investigation of these ...

    • Genome-wide SNP analyses reveal population structure of Portunus pelagicus alongVietnam coastline 

      Dang, BT; Rahman, MA; Tran, SQ; Glenner, Henrik (Peer reviewed; Journal article, 2019-11-05)
      The blue swimming crab (Portunus pelagicus Linnaeus, 1758) is one of the commercially exploited crab fishery resources in Vietnam. This is the first study to provide a broad survey of genetic diversity, population structure ...

    • Genome-wide transcription analysis of histidine-related cataract in Atlantic salmon (Salmo salar L) 

      Tröße, Christiane; Waagbø, Rune; Breck, Olav; Stavrum, Anne-Kristin; Petersen, Kjell; Olsvik, Pål A. (Peer reviewed; Journal article, 2009-07-09)
      Purpose: Elevated levels of dietary histidine have previously been shown to prevent or mitigate cataract formation in farmed Atlantic salmon (Salmo salar L). The aim of this study was to shed light on the mechanisms by ...

    • Genomes of Thaumarchaeota from deep sea sediments reveal specific adaptations of three independently evolved lineages 

      Kerou, Melina; Ponce-Toledo, Rafael I.; Zhao, Rui; Abby, Sophie S.; Hirai, Miho; Nomaki, Hidetaka; Takaki, Yoshihiro; Nunoura, Takuro; Jørgensen, Steffen Leth; Schleper, Christa (Journal article; Peer reviewed, 2021)
      Marine sediments represent a vast habitat for complex microbiomes. Among these, ammonia oxidizing archaea (AOA) of the phylum Thaumarchaeota are one of the most common, yet little explored, inhabitants, which seem ...

    • Genomic Adaptations to an Endoparasitic Lifestyle in the Morphologically Atypical Crustacean Sacculina carcini (Cirripedia: Rhizocephala) 

      Martin, Sebastian; Lesny, Peter; Glenner, Henrik; Hecht, Jochen; Vilcinskas, Andreas; Bartolomaeus, Thomas; Podsiadlowski, Lars (Journal article; Peer reviewed, 2022)
      The endoparasitic crustacean Sacculina carcini (Cirripedia: Rhizocephala) has a much simpler morphology than conventional filter-feeding barnacles, reflecting its parasitic lifestyle. To investigate the molecular basis of ...

    • Genomic alterations associated with mutational signatures, DNA damage repair and chromatin remodeling pathways in cervical carcinoma 

      Halle, Mari Kyllesø; Sundaresan, Aishwarya; Zhang, Jianqing; Pedamallu, Chandra S.; Srinivasasainagendra, Vinodh; Blair, Jessica; Brooke, Dewey; Bertelsen, Bjørn; Woie, Kathrine; Shrestha, Sadeep; Tiwari, Hemant K.; Wong, Yick Fu; Krakstad, Camilla; Ojesina, Akinyemi I (Journal article; Peer reviewed, 2021)
      Despite recent advances in the prevention of cervical cancer, the disease remains a leading cause of cancer-related deaths in women worldwide. By applying the GISTIC2.0 and/or the MutSig2CV algorithms on 430 whole-exome-sequenced ...

    • Genomic analysis of pasteurella atlantica provides insight on its virulence factors and phylogeny and highlights the potential of reverse vaccinology in aquaculture 

      Ellul, Rebecca Marie; Kalatzis, Panos G.; Frantzen, Cyril Alexander; Haugland, Gyri Teien; Gulla, Snorre; Colquhoun, Duncan John; Middelboe, Mathias; Wergeland, Heidrun Inger; Rønneseth, Anita (Journal article; Peer reviewed, 2021)
      Pasteurellosis in farmed lumpsuckers, Cyclopterus lumpus, has emerged as a serious disease in Norwegian aquaculture in recent years. Genomic characterization of the causative agent is essential in understanding the biology ...

    • Genomic analysis reveals neutral and adaptive patterns that challenge the current management regime for East Atlantic cod Gadus morhua L 

      Johansen, Torild; Besnier, Francois; Sanchez, Maria Quintela; Jorde, Per Erik; Glover, Kevin; Westgaard, Jon-Ivar; Dahle, Geir; Lien, Sigbjørn; Kent, Matthew Peter (Journal article; Peer reviewed, 2020)
      Challenging long‐held perceptions of fish management units can help to protect vulnerable stocks. When a fishery consisting of multiple genetic stocks is managed as a single unit, overexploitation and depletion of minor ...

    • Genomic characterization and phylogenetic position of two new species in Rhabdoviridae infecting the parasitic copepod, salmon louse (Lepeophtheirus salmonis) 

      Økland, Arnfinn Lodden; Nylund, Are; Øvergård, Aina-Cathrine; Blindheim, Steffen H.; Watanabe, Kuninori; Grotmol, Sindre; Arnesen, Carl-Erik; Plarre, Heidrun (Peer reviewed; Journal article, 2014-11-17)
      Several new viruses have emerged during farming of salmonids in the North Atlantic causing large losses to the industry. Still the blood feeding copepod parasite, Lepeophtheirus salmonis, remains the major challenge for ...

    • Genomic characterization and therapeutic targeting of HPV undetected cervical carcinomas 

      Ruiz, Fiona J.; Sundaresan, Aishwarya; Zhang, Jin; Pedamallu, Chandra S.; Halle, Mari K.; Srinivasasainagendra, Vinodh; Zhang, Jianqing; Muhammad, Naoshad; Stanley, Jennifer; Markovina, Stephanie; Tiwari, Hemant K.; Grigsby, Perry W.; Krakstad, Camilla; Schwarz, Julie K.; Ojesina, Akinyemi I. (Journal article; Peer reviewed, 2021)
      Cervical cancer tumors with undetectable HPV (HPVU) have been underappreciated in clinical decision making. In this study, two independent CC datasets were used to characterize the largest cohort of HPVU tumors to date ...

    • Genomic epidemiology of Streptococcus dysgalactiae subsp. equisimilis strains causing invasive disease in Norway during 2018 

      Kaci, Alba; Jonassen, Christine M; Skrede, Steinar; Sivertsen, Audun; Steinbakk, Martin; Oppegaard, Oddvar (Journal article; Peer reviewed, 2023)
      Background: Streptococcus dysgalactiae subspecies equisimilis (SDSE) is an emerging global pathogen, yet the epidemiology and population genetics of SDSE species have not been extensively characterized. Methods: We ...

    • Genomic evidence of recent European introgression into North American farmed and wild Atlantic salmon 

      Bradbury, Ian R.; Lehnert, Sarah Jean; Kess, Tony; Van Wyngaarden, Mallory; Duffy, Steven; Messmer, Amber M.; Wringe, Brendan; Karoliussen, Silje; Dempson, J. Brian; Fleming, Ian A.; Solberg, Monica Favnebøe; Glover, Kevin Alan; Bentzen, Paul (Journal article; Peer reviewed, 2022)
      Gene flow between wild and domestic populations has been repeatedly demonstrated across a diverse range of taxa. Ultimately, the genetic impacts of gene flow from domestic into wild populations depend both on the degree ...