Browsing Bergen Open Research Archive by Title

Now showing items 14003-14022 of 34308

    • Human cognitive ability is influenced by genetic variation in components of postsynaptic signalling complexes assembled by NMDA receptors and MAGUK proteins 

      Hill, Wayne David; Davies, Gail; Van De Lagemaat, Louie N.; Christoforou, Andrea; Marioni, Riccardo R.; Duarte Fernandes, Carla; Liewald, David Cherry; Croning, Mike D.R.; Payton, Anthony; Craig, Leone C.A.; Whalley, Lawrence J.; Horan, Michael; Ollier, William E.R.; Hansell, Narelle K.; Wright, Margaret J.; Martin, Nicholas G.; Montgomery, Grant W.; Steen, Vidar Martin; Le Hellard, Stephanie; Espeseth, Thomas; Lundervold, Astri; Reinvang, Ivar; Starr, John M.; Pendleton, Neil; Grant, Seth G.N.; Bates, Timothy C.; Deary, Ian John (Peer reviewed; Journal article, 2014)
      Differences in general cognitive ability (intelligence) account for approximately half of the variation in any large battery of cognitive tests and are predictive of important life events including health. Genome-wide ...

    • Human computer interaction design for data mining in cancer registries 

      Kanza, Grace Benjamin (Master thesis, 2014-06-01)
      Cancer registries are created, managed and data mined to gain knowledge about long-term outcomes, effects of the medication and clinical factors influencing the patient well-being. Such clinical registries have been a good ...

    • The human dimension of biodiversity changes on islands 

      Nogué, Sandra; Santos, Ana; Birks, Harry John Betteley; Björck, Svante; Castilla-Beltrán, Alvaro; Connor, Simon; de Boer, Erik J.; de Nascimento, Lea; Felde, Vivian Astrup; Fernández-Palacios, José María; Froyd, Cynthia; Haberle, Simon G.; Hooghiemstra, Henry; Ljung, Karl; Norder, Sietze J.; Peñuelas, Josep; Prebble, Matthew; Stevenson, Janelle; Whittaker, Robert J.; Willis, Kathy J.; Wilmshurst, Janet M.; Steinbauer, Manuel (Journal article; Peer reviewed, 2021)
      Islands are among the last regions on Earth settled and transformed by human activities, and they provide replicated model systems for analysis of how people affect ecological functions. By analyzing 27 representative ...

    • Human Embryonic Development : Effects of Physical Activity and Sleep in Physiological Pregnancies 

      Vietheer, Alexander (Doctoral thesis, 2024-05-03)
      Bakgrunn: Forskningsfeltet "Developmental Origin of Health and Disease" (DOHaD) har vist hvor betydningsfull fosterutviklingen er for individets fremtidige helse og sykdomsrisiko. I senere år har den tidligste perioden av ...

    • Human footprints provide snapshot of last interglacial ecology in the Arabian interior 

      Stewart, Mathew; Clark-Wilson, Richard; Breeze, Paul S; Janulis, Klint; Candy, Ian; Armitage, Simon James; Ryves, David B.; Louys, Julien; Duval, Mathieu; Price, Gilbert J; Cuthbertson, Patrick; Bernal, Marco A.; Drake, Nick A; Alsharekh, Abdullah; Zahrani, Badr; Al-Omari, Abdulaziz; Roberts, Patrick; Groucutt, Huw S.; Petraglia, Michael D. (Journal article; Peer reviewed, 2020)
      The nature of human dispersals out of Africa has remained elusive because of the poor resolution of paleoecological data in direct association with remains of the earliest non-African people. Here, we report hominin and ...

    • Human gain-of-function variants in HNF1A confer protection from diabetes but independently increase hepatic secretion of atherogenic lipoproteins 

      DeForest, Natalie; Kavitha, Babu; Hu, Siqi; Isaac, Roi; Krohn, Lynne; Wang, Minxian; Du, Xiaomi; De Arruda Saldanha, Camila; Gylys, Jenny; Merli, Edoardo; Abagyan, Ruben; Najmi, Laeya Abdoli; Mohan, Viswanathan; Flannick, Jason; Peloso, Gina M.; Gordts, Philip L.S.M.; Heinz, Sven; Deaton, Aimee M.; Khera, Amit V.; Olefsky, Jerrold; Radha, Venkatesan; Majithia, Amit R. (Journal article; Peer reviewed, 2023)
      Loss-of-function mutations in hepatocyte nuclear factor 1A (HNF1A) are known to cause rare forms of diabetes and alter hepatic physiology through unclear mechanisms. In the general population, 1:100 individuals carry a ...

    • Human gingival epithelial cells stimulate proliferation, migration, and tube formation of lymphatic endothelial cells in vitro 

      Indrelid, Stine Hufthammer; Dongre, Harsh Nitin; Nunes, Ivana Pereira; Virtej, Anca; Bletsa, Athanasia; Berggreen, Ellen (Journal article; Peer reviewed, 2023)
      Objective The aim of this study was to investigate the response of gingival epithelial cells to microbial and inflammatory signals. Background The gingival epithelial barrier provides the first line of defense and ...

    • Human intracranial pulsatility during the cardiac cycle: a computational modelling framework 

      Causemann, Marius; Vinje, Vegard; Rognes, Marie Elisabeth (Journal article; Peer reviewed, 2022)
      Background Today’s availability of medical imaging and computational resources set the scene for high-fidelity computational modelling of brain biomechanics. The brain and its environment feature a dynamic and complex ...

    • A human iPSC-astroglia neurodevelopmental model reveals divergent transcriptomic patterns in schizophrenia 

      Szabo, Attila; Akkouh, Ibrahim Ahmed; Vandenberghe, Matthieu; Osete, Jordi Requena; Hughes, Timothy; Heine, Vivi M.; Smeland, Olav Bjerkehagen; Glover, Joel Clinton; Andreassen, Ole; Djurovic, Srdjan (Journal article; Peer reviewed, 2021)
      While neurodevelopmental abnormalities have been associated with schizophrenia (SCZ), the role of astroglia in disease pathophysiology remains poorly understood. In the present study, we used a human induced pluripotent ...

    • Human Leukocyte Antigen alleles associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) 

      Lande, Asgeir; Fluge, Øystein; Strand, Elin Bolle; Flåm, Siri Tennebø; Sosa, Daisy Duarte; Mella, Olav; Egeland, Torstein; Saugstad, Ola Didrik; Lie, Benedicte Alexandra; Viken, Marte K (Journal article; Peer reviewed, 2020)
      The etiology and pathogenesis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) are unknown, and autoimmunity is one of many proposed underlying mechanisms. Human Leukocyte Antigen (HLA) associations are ...

    • Human mucosal IgA immune responses against enterotoxigenic escherichia coli 

      Riaz, Saman; Steinsland, Hans; Hanevik, Kurt (Journal article; Peer reviewed, 2020-08-29)
      Infection with enterotoxigenic Escherichia coli (ETEC) is a major contributor to diarrheal illness in children in low- and middle-income countries and travelers to these areas. There is an ongoing effort to develop vaccines ...

    • Human myelin protein P2: from crystallography to time-lapse membrane imaging and neuropathy-associated variants 

      Uusitalo, Maiju; Klenow, Martin Berg; Laulumaa, Saara; Blakeley, Matthew P.; Simonsen, Adam Cohen; Ruskamo, Salla; Kursula, Petri (Journal article; Peer reviewed, 2021)
      Peripheral myelin protein 2 (P2) is a fatty acid-binding protein expressed in vertebrate peripheral nervous system myelin, as well as in human astrocytes. Suggested functions of P2 include membrane stacking and lipid ...

    • Human myelin proteolipid protein structure and lipid bilayer stacking 

      Ruskamo, Salla; Raasakka, Arne; Pedersen, Jan Skov; Martel, Anne; Škubník, Karel; Darwish, Tamim; Porcar, Lionel; Kursula, Petri (Journal article; Peer reviewed, 2022)
      The myelin sheath is an essential, multilayered membrane structure that insulates axons, enabling the rapid transmission of nerve impulses. The tetraspan myelin proteolipid protein (PLP) is the most abundant protein of ...

    • The Human N-Alpha-Acetyltransferase 40 (hNaa40p/ hNatD) Is Conserved from Yeast and N-Terminally Acetylates Histones H2A and H4 

      Hole, Kristine; Van Damme, Petra; Dalva, Monica; Aksnes, Henriette; Glomnes, Nina; Varhaug, Jan Erik; Lillehaug, Johan; Gevaert, Kris; Arnesen, Thomas (Peer reviewed; Journal article, 2011-09-15)
      Protein Na-terminal acetylation (Nt-acetylation) is considered one of the most common protein modification in eukaryotes, and 80-90% of all soluble human proteins are modified in this way, with functional implications ...

    • Human NAA30 can rescue yeast mak3∆ mutant growth phenotypes 

      Drazic, Adrian; Varland, Sylvia (Journal article; Peer reviewed, 2021)
      N-terminal acetylation is an irreversible protein modification that primarily occurs co-translationally, and is catalyzed by a highly conserved family of N-terminal acetyltransferases (NATs). The NatC complex (NAA30–NAA35–NAA38) ...

    • The human NAD metabolome: Functions, metabolism and compartmentalization 

      Nikiforov, Andrey; Kulikova, Veronika; Ziegler, Mathias (Peer reviewed; Journal article, 2015)
      The metabolism of NAD has emerged as a key regulator of cellular and organismal homeostasis. Being a major component of both bioenergetic and signaling pathways, the molecule is ideally suited to regulate metabolism and ...

    • Human nature is present. Approaching performance art through neuroscience with Example of ”The Artist is Present” (2010) by Marina Abramović 

      Longva, Fredrik Boye (Master thesis, 2015-05-15)
      Approaching Performance Art through Neuroscience with Example of "The Artist is Present" (2010) by Marina Abramović. In this master thesis, I demonstrate and discuss how perspectives from cognitive neuroscience can ...

    • Human organotypic airway and lung organoid cells of bronchiolar and alveolar differentiation are permissive to infection by influenza and SARS-CoV-2 respiratory virus 

      Ekanger, Camilla Tvedt; Zhou, Fan; Bohan, Dana; Lotsberg, Maria Lie; Ramnefjell, Maria; Hoareau, Laurence; Røsland, Gro Vatne; Lu, Ning; Aanerud, Marianne; Gärtner, Fabian; Salminen, Pirjo-Riitta; Bentsen, Mariann; Halvorsen, Thomas; Ræder, Helge; Akslen, Lars Andreas; Langeland, Nina; Brokstad, Rebecca Jane Cox; Maury, Wendy; Stuhr, Linda Elin Birkhaug; Lorens, James; Engelsen, Agnete Svendsen Tenfjord (Journal article; Peer reviewed, 2022)
      The ongoing coronavirus disease 2019 (COVID-19) pandemic has led to the initiation of unprecedented research efforts to understand the pathogenesis mediated by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). ...

    • Human pancreatic glucokinase. Structural and physico-chemical studies related to catalytic activation, kinetic cooperativity and GCK-diabetes. 

      Molnes, Janne (Doctoral thesis, 2012-10-19)
      Glucokinase (GK) functions as a glucose sensor in insulin-producing pancreatic-cells and as a regulator of hepatic glycolysis, glycogen synthesis and gluconeogenesis. Its key role in glucose homeostasis is evidenced by ...

    • Human remains from Tegea 

      Ingvarsson-Sundström, Anne (Papers and Monographs from the Norwegian Institute at Athens. series 4o, volume 4, Chapter, 2014)