Blar i Bergen Open Research Archive på tittel

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    • Identification and Description of the Key Molecular Components of the Egg Strings of the Salmon Louse (Lepeophtheirus salmonis) 

      Borchel, Andreas; Kongshaug, Heidi; Nilsen, Frank (Peer reviewed; Journal article, 2019-12-03)
      The salmon louse Lepeophtheirus salmonis is a parasite of Atlantic salmon and other salmonids. Every year, it causes high costs for the Norwegian aquaculture industry. While the morphology of the female genital tract has ...

    • Identification and development of small molecule therapies for the treatment of acute myeloid leukaemia 

      Leitch, Calum (Doctoral thesis, 2022-02-11)
      Acute myeloid leukaemia (AML) is a cancer of the bone marrow in which immature myeloid cells exhibit uncontrolled proliferation and failure to differentiate. The global 5-year overall survival rate for AML ranges between ...

    • Identification and functional characterization of a novel susceptibility locus for small vessel vasculitis with MPO-ANCA 

      Dahlqvist, Johanna; Ekman, Diana; Sennblad, Bengt; Kozyrev, Sergey V.; Nordin, Jessika; Karlsson, Åsa; Meadows, Jennifer R. S.; Hellbacher, Erik; Rantapää-Dahlqvist, Solbritt; Berglin, Ewa; Stegmayr, Bernd; Haslund, Bo; Palm, Øyvind; Haukeland, Hilde; Gunnarsson, Iva; Bruchfeld, Annette; Segelmark, Mårten; Ohlsson, Sophie; Mohammad, Aladdin J.; Svärd, Anna Jessica; Pullerits, Rille; Herlitz, Hans; Söderbergh, Annika; Pielberg, Gerli Rosengren; Rosenberg, Lina Hultin; Bianchi, Matteo; Muren, Eva; Omdal, Roald; Jonsson, Roland; Eloranta, Maija-Leena; Rönnblom, Lars; Söderkvist, Peter; Knight, Ann; Eriksson, Per; Lindblad-Toh, Kerstin (Journal article; Peer reviewed, 2021)
      Objective To identify and characterize genetic loci associated with the risk of developing ANCA-associated vasculitides (AAV). Methods Genetic association analyses were performed after Illumina sequencing of 1853 genes ...

    • Identification and genetic characterization of Saprolegnia parasitica, isolated from farmed and wild fish in Finland 

      Engblom, Christine; Landor, Lotta Anni Ingeborg; Sjöqvist, Conny; Korkea-aho, Tiina; Viljamaa-Dirks, Satu; Paulin, Lars; Wiklund, Tom (Journal article; Peer reviewed, 2023)
      Oomycete infections in farmed fish are one of the most significant disease issues in salmonid aquaculture worldwide. In the present study, Saprolegnia spp. in different farmed fish species in Finland were identified, and ...

    • Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31 

      Permuth-Wey, Jennifer; Lawrenson, K; Shen, HC; Velkova, A; Tyrer, JP; Chen, ZH; Lin, HY; Chen, YA; Tsai, YY; Qu, XT; Ramus, SJ; Karevan, R; Lee, J; Lee, N; Larson, MC; Aben, KK; Anton-Culver, H; Antonenkova, N; Antoniou, AC; Armasu, SM; Bacot, F; Baglietto, L; Bandera, EV; Barnholtz-Sloan, J; Beckmann, MW; Birrer, MJ; Bloom, G; Bogdanova, N; Brinton, LA; Brooks-Wilson, A; Brown, R; Butzow, R; Cai, QY; Campbell, I; Chang-Claude, J; Chanock, S; Chenevix-Trench, G; Cheng, JQ; Cicek, MS; Coetzee, GA; Cook, LS; Couch, FJ; Cramer, DW; Cunningham, JM; Dansonka-Mieszkowska, A; Despierre, E; Doherty, JA; Dork, T; du Bois, A; Durst, M; Easton, DF; Eccles, D; Edwards, R; Ekici, AB; Fasching, PA; Fenstermacher, DA; Flanagan, JM; Garcia-Closas, M; Gentry-Maharaj, A; Giles, GG; Glasspool, RM; Gonzalez-Bosquet, J; Goodman, MT; Gore, M; Gorski, B; Gronwald, J; Hall, P; Halle, Mari Kyllesø; Harter, P; Heitz, F; Hillemanns, P; Hoatlin, M; Hogdall, CK; Hogdall, E; Hosono, S; Jakubowska, A; Jensen, A; Jim, H; Kalli, KR; Karlan, BY; Kaye, SB; Kelemen, LE; Kiemeney, LA; Kikkawa, F; Konecny, GE; Krakstad, Camilla; Kjaer, SK; Kupryjanczyk, J; Lambrechts, D; Lambrechts, S; Lancaster, JM; Le, ND; Leminen, A; Levine, DA; Liang, D; Lim, BK; Lin, J; Lissowska, J; Lu, KH; Lubinski, J; Lurie, G; Massuger, LFAG; Matsuo, K; McGuire, V; McLaughlin, JR; Menon, U; Modugno, F; Moysich, KB; Nakanishi, T; Narod, SA; Nedergaard, L; Ness, RB; Nevanlinna, H; Nickels, S; Noushmehr, H; Odunsi, K; Olson, SH; Orlow, I; Paul, J; Pearce, CL; Pejovic, T; Pelttari, LM; Pike, MC; Poole, EM; Raska, P; Renner, SP; Risch, HA; Rodriguez-Rodriguez, L; Rossing, MA; Rudolph, A; Runnebaum, IB; Rzepecka, IK; Salvesen, Helga Birgitte; Schwaab, I; Severi, G; Shridhar, V; Shu, XO; Shvetsov, YB; Sieh, W; Song, HL; Southey, MC; Spiewankiewicz, B; Stram, D; Sutphen, R; Teo, SH; Terry, KL; Tessier, DC; Thompson, PJ; Tworoger, SS; van Altena, AM; Vergote, I; Vierkant, RA; Vincent, D; Vitonis, AF; Wang-Gohrke, S; Weber, RP; Wentzensen, N; Whittemore, AS; Wik, Elisabeth; Wilkens, LR; Winterhoff, B; Woo, YL; Wu, AH; Xiang, YB; Yang, HP; Zheng, W; Ziogas, A; Zulkifli, F; Phelan, CM; Iversen, E; Schildkraut, JM; Berchuck, A; Fridley, BL; Goode, EL; Pharoah, PDP; Monteiro, ANA; Sellers, TA; Gayther, SA (Peer reviewed; Journal article, 2013-03-27)
      Epithelial ovarian cancer (EOC) has a heritable component that remains to be fully characterized. Most identified common susceptibility variants lie in non-protein-coding sequences. We hypothesized that variants in the 3′ ...

    • Identification and molecular characterization of two acetylcholinesterases from the salmon louse, Lepeophtheirus salmonis 

      Kaur, Kiranpreet; Bakke, Marit Jørgensen; Nilsen, Frank; Horsberg, Tor Einar (Peer reviewed; Journal article, 2015-05-04)
      Acetylcholinesterase (AChE) is an important enzyme in cholinergic synapses. Most arthropods have two genes (ace1 and ace2), but only one encodes the predominant synaptic AChE, the main target for organophosphates. Resistance ...

    • Identification and quantification of soundscape components in the Marginal Ice Zone 

      Geyer, Florian; Sagen, Hanne; Hope, Gaute; Babiker, Mohamed; Worcester, Peter F. (Peer reviewed; Journal article, 2016)
      Acoustic experiments using an integrated ice station were carried out during August 2012 and September 2013 in the Marginal Ice Zone (MIZ) of Fram Strait. The two experiments lasted four days each and collected under-ice ...

    • Identification and quantification of valuable platform chemicals in aqueous product streams from a preliminary study of a large pilot-scale steam explosion of woody biomass using quantitative nuclear magnetic resonance spectroscopy 

      Ghoreishi, Solmaz; Løhre, Camilla; Hermundsgård, Dag Helge; Molnes, Joakim Lindgaard; Tanase-Opedal, Mihaela; Brusletto, Rune; Barth, Tanja (Journal article; Peer reviewed, 2022)
      Steam explosion breaks down the polymeric matrix and enables the recovery of valuable compounds from lignocellulosic feedstock. In the steam explosion process, biomass is treated with high-pressure steam which subsequently ...

    • Identification of a Blood-Based Protein Biomarker Panel for Lung Cancer Detection 

      El-Khoury, Victoria; Schritz, Anna; Kim, Sang-Yoon; Lesur, Antoine; Sertamo, Katriina; Bernardin, Francois; Petritis, Konstantinos; Pirrotte, Patrick; Selinsky, Cheryl; Whiteaker, Jeffrey R; Zhang, Haizhen; Kennedy, Jacob J; Lin, Chenwei; Lee, Lik Wee; Yan, Ping; Tran, Nhan L; Inge, Landon J; Chalabi, Khaled; Decker, Georges; Bjerkvig, Rolf; Paulovich, Amanda G; Berchem, Guy; Kim, Yeoun Jin (Journal article; Peer reviewed, 2020)
      Lung cancer is the deadliest cancer worldwide, mainly due to its advanced stage at the time of diagnosis. A non-invasive method for its early detection remains mandatory to improve patients’ survival. Plasma levels of 351 ...

    • Identification of a core EMT signature that separates basal-like breast cancers into partial- and post-EMT subtypes 

      Knutsen, Erik; Sajib, Saikat Das; Fiskaa, Tonje; Lorens, James Bradley; Gudjonsson, Thorarinn; Mælandsmo, Gunhild Mari; Johansen, Steinar Daae; Seternes, Ole Morten; Perander, Maria (Journal article; Peer reviewed, 2023)
      Epithelial-mesenchymal transition (EMT) is a cellular plasticity program critical for embryonic development and tissue regeneration, and aberrant EMT is associated with disease including cancer. The high degree of plasticity ...

    • Identification of a nonlinear parameter in a parabolic equation by a linear approach 

      Tai, Xue-Cheng; Kärkkäinen, Tommi (Department of Applied Mathematics report, Research report, 1993-03)

    • Identification of a novel polymorphism associated with reduced clozapine concentration in schizophrenia patients—a genome-wide association study adjusting for smoking habits 

      Smith, Robert Løvsletten; O’Connell, Kevin; Athanasiu, Lavinia; Djurovic, Srdjan; Kringen, Marianne K.; Andreassen, Ole Andreas; Molden, Espen (Journal article; Peer reviewed, 2020)
      Clozapine (CLZ) is the superior antipsychotic drug for treatment of schizophrenia, but exhibits an extensive interpatient pharmacokinetic variability. Here, we conducted a genome-wide association study (GWAS) of CLZ serum ...

    • Identification of a Phage Display-Derived Peptide Interacting with the N-Terminal Region of Factor VII Activating Protease (FSAP) Enables Characterization of Zymogen Activation 

      Berge-Seidl, Sebastian; Nielsen, Nis Valentin; Alfonso, Armando A Rodriguez; Etscheid, Michael; Kandanur, Sai Priya Sarma; Haug, Bengt Erik; Stensland, Maria; Thiede, Bernd; Karacan, M; Preising, N; Wiese, S; Standker, L; Declerck, Paul J.; Løset, Geir Åge; Kanse, Sandip (Journal article; Peer reviewed, 2022)
      Factor VII Activating protease (FSAP) has a protective effect in diverse disease conditions as inferred from studies in FSAP–/– mice and humans deficient in FSAP activity due to single-nucleotide polymorphism. The zymogen ...

    • Identification of a potential allosteric site of Golgi α-mannosidase II using computer-aided drug design 

      Irsheid, Lina; Wehler, Thomas; Borek, Christoph; Kiefer, Werner; Brenk, Ruth; Ortiz-Soto, Maria Elena; Seibel, Jurgen; Schirmeister, Tanja (Peer reviewed; Journal article, 2019-05-08)
      Golgi α-mannosidase II (GMII) is a glycoside hydrolase playing a crucial role in the N-glycosylation pathway. In various tumour cell lines, the distribution of N-linked sugars on the cell surface is modified and correlates ...

    • Identification of acute coronary syndrome in the era of high-sensitivity troponin assays 

      Steiro, Ole-Thomas (Doctoral thesis, 2023-06-02)
      Bakgrunn: Det er mulig å bedre pasientflyt og diagnostisk presisjon ved utredning av pasienter med mistenkt akutt koronarsyndrom (AKS). Konsentrasjonen av kardialt troponin (cTnT eller cTnI) kan benyttes til å forutse ...

    • Identification of biomarkers for glycaemic deterioration in type 2 diabetes 

      Slieker, Roderick C.; Donnelly, Louise A.; Akalestou, Elina; Lopez-Noriega, Livia; Melhem, Rana; Güneş, Ayşim; Abou Azar, Frederic; Efanov, Alexander; Georgiadou, Eleni; Muniangi-Muhitu, Hermine; Sheikh, Mahsa; Giordano, Giuseppe N.; Åkerlund, Mikael; Ahlqvist, Emma; Ali, Ashfaq; Banasik, Karina; Brunak, Søren; Barovic, Marko; Bouland, Gerard A.; Burdet, Frédéric; Canouil, Mickaël; Dragan, Iulian; Elders, Petra J. M.; Fernandez, Celine; Festa, Andreas; Fitipaldi, Hugo; Froguel, Phillippe; Gudmundsdottir, Valborg; Gudnason, Vilmundur; Gerl, Mathias J.; van der Heijden, Amber A.; Jennings, Lori L.; Hansen, Michael K.; Kim, Min; Leclerc, Isabelle; Klose, Christian; Kuznetsov, Dmitry; Mansour Aly, Dina; Mehl, Florence; Marek, Diana; Melander, Olle; Niknejad, Anne; Ottosson, Filip; Pavo, Imre; Duffin, Kevin; Syed, Samreen K.; Shaw, Janice L.; Cabrera, Over; Pullen, Timothy J.; Simons, Kai; Solimena, Michele; Suvitaival, Tommi; Wretlind, Asger; Rossing, Peter; Lyssenko, Valeriya; Legido Quigley, Cristina; Groop, Leif; Thorens, Bernard; Franks, Paul W.; Lim, Gareth E.; Estall, Jennifer; Ibberson, Mark; Beulens, Joline W. J.; ’t Hart, Leen M; Pearson, Ewan R.; Rutter, Guy A. (Journal article; Peer reviewed, 2023)
      We identify biomarkers for disease progression in three type 2 diabetes cohorts encompassing 2,973 individuals across three molecular classes, metabolites, lipids and proteins. Homocitrulline, isoleucine and 2-aminoadipic ...

    • Identification of boosted Higgs bosons decaying into b-quark pairs with the ATLAS detector at 13 TeV 

      Aad, Georges; Abbott, Brad; Abbott, Dale C.; Abdinov, Ovsat Bahram oglu; Abed Abud, Adam; Abeling, Kira; Abhayasinghe, Deshan Kavishka; Abidi, Syed Haider; AbouZeid, Hass; Abraham, Nadine L.; Bjørke, Kristian; Bugge, Magnar Kopangen; Cameron, David Gordon; Catmore, James Richard; Feigl, Simon; Garonne, Vincent; Gramstad, Eirik; Hellesund, Simen; Morisbak, Vanja; Oppen, Henrik; Ould-Saada, Farid; Pedersen, Maiken; Read, Alexander Lincoln; Røhne, Ole Myren; Sandaker, Heidi; Vadla, Knut Oddvar Høie; Buanes, Trygve; Djuvsland, Julia Isabell; Eigen, Gerald; Fomin, Nikolai; Lee, Graham Richard; Lipniacka, Anna; Martin dit Latour, Bertrand; Mæland, Steffen; Stugu, Bjarne; Træet, Are Sivertsen; Abramowicz, Halina; Abreu, Henso; Abulaiti, Yiming; Acharya, Bobby S.; Achkar, Baida; Adachi, Shunsuke; Adam, Lennart; Adam-Bourdarios, Claire; Adamczyk, Leszek; Adamek, Lukas; Adelman, Jareed; Adersberger, Michael; Adigüzel, Aytül; Adorni, Sofia; ATLAS, Collaboration (Peer reviewed; Journal article, 2019)
      This paper describes a study of techniques for identifying Higgs bosons at high transverse momenta decaying into bottom-quark pairs, H→bb¯, for proton–proton collision data collected by the ATLAS detector at the Large ...

    • Identification of BST2 Contributing to the Development of Glioblastoma Based on Bioinformatics Analysis 

      Kong, Yang; Xue, Zhiwei; Wang, Haiying; Cui, Guangqiang; Chen, Anjing; Liu, Jie; Wang, Jian; Li, Xingang; Huang, Bin (Journal article; Peer reviewed, 2022)
      Rigorous molecular analysis of the immune cell environment and immune response of human tumors has led to immune checkpoint inhibitors as one of the most promising strategies for the treatment of human cancer. However, in ...

    • Identification of critical enzymes in the salmon louse chitin synthesis pathway as revealed by RNA interference-mediated abrogation of infectivity 

      Braden, Laura; Michaud, Dylan; Igboeli, Okechukwu O.; Dondrup, Michael; Hamre, Lars Are; Dalvin, Sussie; Purcell, Sara; Kongshaug, Heidi; Eichner, Christiane; Nilsen, Frank; Fast, Mark D. (Journal article; Peer reviewed, 2020)
      Treatment of infestation by the ectoparasite Lepeophtheirus salmonis relies on a small number of chemotherapeutant treatments that currently meet with limited success. Drugs targeting chitin synthesis have been largely ...

    • Identification of Cumin (Cuminum cyminum) MicroRNAs through Deep Sequencing and Their Impact on Plant Secondary Metabolism 

      Reyes-Calderón, Almendra; Gutiérrez-García, Claudia; Urióstegui-Pena, Andrea G.; Srivastava, Aashish; Aguilar-Marcelino, Liliana; Iqbal, Hafiz M. N.; Ahmed, Shiek S. S. J.; Paul, Sujay; Sharma, Ashutosh (Journal article; Peer reviewed, 2023-04-25)
      The pharmacological properties of plants lie in the content of secondary metabolites that are classified into different categories based on their biosynthesis, structures, and functions. MicroRNAs (miRNAs) are small ...