Blar i Bergen Open Research Archive på forfatter "Goksøyr, Anders"
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Liver transcriptome analysis of Atlantic cod (Gadus morhua) exposed to PCB 153 indicates effects on cell cycle regulation and lipid metabolism
Yadetie, Fekadu; Karlsen, Odd André; Eide, Marta; Hogstrand, Christer; Goksøyr, Anders (Peer reviewed; Journal article, 2014-06-17)Background: Polychlorinated biphenyls (PCBs) are persistent organic pollutants (POPs) with harmful effects in animals and humans. Although PCB 153 is one of the most abundant among PCBs detected in animal tissues, its ... -
Machine Learning Approaches for Biomarker Discovery Using Gene Expression Data
Zhang, Xiaokang; Jonassen, Inge; Goksøyr, Anders (Chapter, 2021)Biomarkers are of great importance in many fields, such as cancer research, toxicology, diagnosis and treatment of diseases, and to better understand biological response mechanisms to internal or external intervention. ... -
Modulation of neuro-dopamine homeostasis in juvenile female Atlantic cod (Gadus morhua) exposed to polycyclic aromatic hydrocarbons and perfluoroalkyl substances
Khan, Essa Ahsan; Bertotto, Luisa B.; Dale, Karina; Lille-Langøy, Roger; Yadetie, Fekadu; Karlsen, Odd Andre; Goksøyr, Anders; Schlenk, Daniel; Arukwe, Augustine (Peer reviewed; Journal article, 2019)The dopaminergic effect of PAH and PFAS mixtures, prepared according to environmentally relevant concentrations, has been studied in juvenile female Atlantic cod (Gadus morhua). Benzo[a]pyrene, dibenzothiophene, fluorene, ... -
Multiple-stressor effects in an apex predator: combined influence of pollutants and sea ice decline on lipid metabolism in polar bears
Tartu, Sabrina; Lille-Langøy, Roger; Størseth, Trond Røvik; Bourgeon, Sophie; Brunsvik, Anders; Goksøyr, Anders; Jenssen, Bjørn Munro; Polder, Anuschka; Thiemann, Gregory W.; Torget, Vidar; Routti, Heli (Peer reviewed; Journal article, 2017-11-28)There is growing evidence from experimental and human epidemiological studies that many pollutants can disrupt lipid metabolism. In Arctic wildlife, the occurrence of such compounds could have serious consequences for ... -
Photo-enhanced toxicity of crude oil on early developmental stages of Atlantic cod (Gadus morhua)
Aranguren Abadía, Libe; Yadetie, Fekadu; Donald, Carey; Sørhus, Elin; Myklatun, Lars Eirik; Zhang, Xiaokang; Lie, Kai Kristoffer; Perrichon, Prescilla; Nakken, Charlotte Langeland; Durif, Caroline; Shema, Steven; Browman, Howard; Skiftesvik, Anne Berit; Goksøyr, Anders; Meier, Sonnich; Karlsen, Odd André (Journal article; Peer reviewed, 2022)Photo-enhanced toxicity of crude oil is produced by exposure to ultraviolet (UV) radiation. Atlantic cod (Gadus morhua) embryos were exposed to crude oil with and without UV radiation (290–400 nm) from 3 days post fertilization ... -
Polycyclic aromatic hydrocarbons modulate the activity of Atlantic cod (Gadus morhua) vitamin D receptor paralogs in vitro
Goksøyr, Siri Øfsthus; Goldstone, Jed; Lille-Langøy, Roger; Lock, Erik Jan Robert; Olsvik, Pål Asgeir; Goksøyr, Anders; Karlsen, Odd André (Journal article; Peer reviewed, 2021)Vitamin D receptor (VDR) mediates the biological function of the steroid hormone calcitriol, which is the metabolically active version of vitamin D. Calcitriol is important for a wide array of physiological functions, ... -
Proteomics and lipidomics analyses reveal modulation of lipid metabolism by perfluoroalkyl substances in liver of Atlantic cod (Gadus morhua)
Dale, Karina; Yadetie, Fekadu; Müller, Mette Helen Bjørge; Pampanin, Daniela Maria; Gilabert, Alejandra; Zhang, Xiaokang; Tairova, Zhanna; Haarr, Ane; Lille-Langøy, Roger; Lyche, Jan Ludvig; Porte, Cinta; Karlsen, Odd Andre; Goksøyr, Anders (Journal article; Peer reviewed, 2020)The aim of the present study was to investigate effects of defined mixtures of polycyclic aromatic hydrocarbons (PAHs) and perfluoroalkyl substances (PFASs), at low, environmentally relevant (1× = L), or high (20× = H) ... -
Quantitative analyses of the hepatic proteome of methylmercury-exposed Atlantic cod (Gadus morhua) suggest oxidative stress-mediated effects on cellular energy metabolism
Yadetie, Fekadu; Bjørneklett, Silje; Garberg, Hilde K; Oveland, Eystein; Berven, Frode; Goksøyr, Anders; Karlsen, Odd André (Peer reviewed; Journal article, 2016-08-05)Background: Methylmecury (MeHg) is a widely distributed environmental pollutant with considerable risk to both human health and wildlife. To gain better insight into the underlying mechanisms of MeHg-mediated toxicity, we ... -
Quantitative transcriptomics, and lipidomics in evaluating ovarian developmental effects in Atlantic cod (Gadus morhua) caged at a capped marine waste disposal site
Khan, Essa Ahsan; Zhang, Xiaokang; Hanna, Eileen Marie; Bartosova, Zdenka; Yadetie, Fekadu; Jonassen, Inge; Goksøyr, Anders; Arukwe, Augustine (Journal article; Peer reviewed, 2020)In the present study, a previously capped waste disposal site at Kollevåg (Norway) was selected to study the effects of contaminant leakage on biomarkers associated with Atlantic cod (Gadus morhua) reproductive endocrinology ... -
ReCodLiver0.9: Overcoming Challenges in Genome-Scale Metabolic Reconstruction of a Non-model Species
Hanna, Eileen Marie; Zhang, Xiaokang; Eide, Marta; Fallahi, Shirin; Furmanek, Tomasz; Yadetie, Fekadu; Zielinski, Daniel Craig; Goksøyr, Anders; Jonassen, Inge (Journal article; Peer reviewed, 2020-11)The availability of genome sequences, annotations, and knowledge of the biochemistry underlying metabolic transformations has led to the generation of metabolic network reconstructions for a wide range of organisms in ... -
Single PFAS and PFAS mixtures affect nuclear receptor- and oxidative stress-related pathways in precision-cut liver slices of Atlantic cod (Gadus morhua)
Dale, Karina; Yadetie, Fekadu; Horvli, Torill; Zhang, Xiaokang; Frøysa, Håvard G; Karlsen, Odd André; Goksøyr, Anders (Journal article; Peer reviewed, 2022)The aim of the present study was to investigate effects of per- and polyfluoroalkyl substances (PFAS), both single compounds and a mixture of these, using precision-cut liver slices (PCLS) from Atlantic cod (Gadus morhua). ... -
Spawning time in adult polar cod (Boreogadus saida) altered by crude oil exposure, independent of food availability
Strople, Leah Catherine; Vieweg, Ireen; Yadetie, Fekadu; Odei, Derrick Kwame; Thorsen, Anders; Karlsen, Odd André; Goksøyr, Anders; Sørensen, Lisbet; Sarno, Antonio; Hansen, Bjørn Henrik; Frantzen, marianne; Hansen, Øyvind J; Puvanendran, Velmurugu; Nahrgang, Jasmine (Journal article; Peer reviewed, 2023)Fish early life stages are well known for their sensitivity to crude oil exposure. However, the effect of crude oil exposure on adults and their gametes during their spawning period is not well studied. Polar cod, a key ... -
Substituted Two- To Five-Ring Polycyclic Aromatic Compounds Are Potent Agonists of Atlantic Cod (Gadus morhua) Aryl Hydrocarbon Receptors Ahr1a and Ahr2a
Lille-Langøy, Roger; Jørgensen, Kåre Bredeli; Goksøyr, Anders; Pampanin, Daniela Maria; Sydnes, Magne Olav; Karlsen, Odd André (Journal article; Peer reviewed, 2021)Polycyclic aromatic hydrocarbons (PAHs) are among the most toxic and bioavailable components found in petroleum and represent a high risk to aquatic organisms. The aryl hydrocarbon receptor (Ahr) is a ligand-activated ... -
Toxicity assessment of urban marine sediments from Western Norway using a battery of stress-activated receptors and cell-based bioassays from fish
Goksøyr, Siri Øfsthus; Sørensen, Helene; Grøsvik, Bjørn Einar; Pampanin, Daniela Maria; Goksøyr, Anders; Karlsen, Odd André (Journal article; Peer reviewed, 2021)A luciferase reporter gene-based bioassay battery consisting of stress-activated receptors from fish, complemented with traditional fish cell-based bioassays, were used to assess the toxicity of marine sediment samples ... -
Transcriptome responses in copepods Calanus finmarchicus, Calanus glacialis and Calanus hyperboreus exposed to phenanthrene and benzo[a]pyrene
Yadetie, Fekadu; Brun, Nadja Rebecca; Giebichenstein, Julia; Dmoch, Katarzyna; Hylland, Ketil; Borgå, Katrine; Karlsen, Odd André; Goksøyr, Anders (Journal article; Peer reviewed, 2022)Arctic and sub-arctic pelagic organisms can be exposed to effluents and spills from offshore petroleum-related activities and thus it is important to understand how they respond to crude oil related contaminants such as ... -
Transcriptome responses in polar cod (Boreogadus saida) liver slice culture exposed to benzo[a]pyrene and ethynylestradiol: insights into anti-estrogenic effects
Yadetie, Fekadu; Brun, Nadja R; Vieweg, Ireen; Nahrgang, Jasmine; Karlsen, Odd André; Goksøyr, Anders (Journal article; Peer reviewed, 2021)Polar cod (Boreogadus saida) is a key species in the arctic marine ecosystem vulnerable to effects of pollution, particularly from petroleum related activities. To facilitate studying the effects of those pollutants, we ... -
Xenobiotic metabolism and its physiological consequences in high‑Antarctic Notothenioid fishes
Strobel, Anneli; Lille-Langøy, Roger; Segner, Helmut; Burkhardt-Holm, Patricia; Goksøyr, Anders; Karlsen, Odd André (Journal article; Peer reviewed, 2022)The Antarctic ecosystem is progressively exposed to anthropogenic contaminants, such as polycyclic aromatic hydrocarbons (PAHs). So far, it is largely unknown if PAHs leave a mark in the physiology of high-Antarctic fish. ...