Blar i Bergen Open Research Archive på forfatter "Kursula, Petri"
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Myelin-derived and putative molecular mimic peptides share structural properties in aqueous and membrane-like environments
Tuusa, Jussi; Raasakka, Arne; Ruskamo, Salla; Kursula, Petri (Peer reviewed; Journal article, 2017-03-24)Background: Despite intense research, the causes of various neurological diseases remain enigmatic to date. A role for viral or bacterial infection and associated molecular mimicry has frequently been suggested in the ... -
Neuropathy-related mutations alter the membrane binding properties of the human myelin protein P0 cytoplasmic tail
Raasakka, Arne; Ruskamo, Salla; Barker, Robert; Krokengen, Oda Caspara; Vatne, Guro Helén; Kristiansen, Cecilie Katrin; Hallin, Erik Ingmar; Skoda, Maximilian W. A.; Bergmann, Ulrich; Wacklin-Knecht, Hanna; Jones, Nykola C; Hoffmann, Søren V; Kursula, Petri (Peer reviewed; Journal article, 2019-06-07)Schwann cells myelinate selected axons in the peripheral nervous system (PNS) and contribute to fast saltatory conduction via the formation of compact myelin, in which water is excluded from between tightly adhered lipid ... -
Phosphatidylserine receptors enhance SARS-CoV-2 infection
Bohan, Dana; Van Ert, Hanora; Ruggio, Natalie; Rogers, Kai J; Badreddine, Mohammad; Aguilar Briseno, José A; Elliff, Jonah; Rojas Chavez, Roberth Anthony; Gao, Boning; Stokowy, Tomasz; Christakou, Eleni; Kursula, Petri; Micklem, David Robert; Gausdal, Gro; Haim, Hillel; Minna, John; Lorens, James Bradley; Maury, Wendy (Journal article; Peer reviewed, 2021)Phosphatidylserine (PS) receptors enhance infection of many enveloped viruses through virion-associated PS binding that is termed apoptotic mimicry. Here we show that this broadly shared uptake mechanism is utilized by ... -
The quaternary structure of human tyrosine hydroxylase: effects of dystonia‐associated missense variants on oligomeric state and enzyme activity
Szigetvari, Peter Daniel; Muruganandam, Gopinath; Kallio, Juha; Hallin, Erik Ingmar; Fossbakk, Agnete; Loris, Remy; Kursula, Inari; Møller, Lisbeth Birk; Knappskog, Per; Kursula, Petri; Haavik, Jan (Journal article; Peer reviewed, 2019)Tyrosine hydroxylase (TH) is a multi-domain, homo-oligomeric enzyme that catalyses the rate-limiting step of catecholamine neurotransmitter biosynthesis. Missense variants of human TH are associated with a recessive ... -
Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity
Kouloulia, Stella; Hallin, Erik Ingmar; Simbriger, Konstanze; Amorim, Ines S; Lach, Gilliard; Amvrosiadis, Theoklitos; Chalkiadaki, Kleanthi; Kampaite, Agniete; Truong, Vinh Tai; Hooshmandi, Mehdi; Jafarnejad, Seyed Mehdi; Skehel, Paul; Kursula, Petri; Khoutorsky, Arkady; Gkogkas, Christos (Peer reviewed; Journal article, 2019)The translation initiation repressor 4E-BP2 is deamidated in the brain on asparagines N99/N102 during early postnatal brain development. This post-translational modification enhances 4E-BP2 association with Raptor, a central ... -
Shanks - multidomain molecular scaffolds of the postsynaptic density
Kursula, Petri (Peer reviewed; Journal article, 2019-03-06)The postsynaptic density (PSD) is a protein-rich assembly below the postsynaptic membrane, formed of large scaffolding proteins. These proteins carry a combination of protein interaction domains, which may interact with ... -
Stability and flexibility of full-length human oligodendrocytic QKI6
Raasakka, Arne; Kursula, Petri (Peer reviewed; Journal article, 2019-09-23)Objective: Oligodendrocytes account for myelination in the central nervous system. During myelin compaction, key proteins are translated in the vicinity of the myelin membrane, requiring targeted mRNA transport. Quaking ... -
Stable preparations of tyrosine hydroxylase provide the solution structure of the full-length enzyme
Bezem, Maria Teresa; Baumann, Anne; Skjærven, Lars; Meyer, Romain; Kursula, Petri; Martinez, Aurora; Flydal, Marte Innselset (Peer reviewed; Journal article, 2016-07-27)Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the biosynthesis of catecholamine neurotransmitters. TH is a highly complex enzyme at mechanistic, structural, and regulatory levels, and the preparation of ... -
Structural and biophysical characterization of transcription factor HNF-1A as a tool to study MODY3 diabetes variants
Kind, Laura; Raasakka, Arne; Molnes, Janne; Aukrust, Ingvild; Bjørkhaug, Lise; Njølstad, Pål Rasmus; Kursula, Petri; Arnesen, Thomas (Journal article; Peer reviewed, 2022)Hepatocyte nuclear factor 1A (HNF-1A) is a transcription factor expressed in several embryonic and adult tissues, modulating the expression of numerous target genes. Pathogenic variants in the HNF1A gene are known to cause ... -
Structural aspects of nucleotide ligand binding by a bacterial 2H phosphoesterase
Myllykoski, Matti; Kursula, Petri (Peer reviewed; Journal article, 2017-01-31)The 2H phosphoesterase family contains enzymes with two His-X-Ser/Thr motifs in the active site. 2H enzymes are found in all kingdoms of life, sharing little sequence identity despite the conserved overall fold and active ... -
Structural insights into Charcot–Marie–Tooth disease-linked mutations in human GDAP1
Sutinen, Aleksi; Nguyen, Giang Thi Tuyet; Raasakka, Arne; Muruganandam, Gopinath; Loris, Remy; Ylikallio, Emil; Tyynismaa, Henna; Bartesaghi, Luca; Ruskamo, Salla; Kursula, Petri (Journal article; Peer reviewed, 2022)Charcot–Marie–Tooth disease (CMT) is the most common inherited peripheral polyneuropathy in humans, and its different subtypes are linked to mutations in dozens of different genes. Mutations in ganglioside-induced ... -
Structural properties and peptide ligand binding of the capsid homology domains of human Arc
Hallin, Erik Ingmar; Bramham, Clive Raymond Evjen; Kursula, Petri (Journal article; Peer reviewed, 2021)The activity-regulated cytoskeleton-associated protein (Arc) is important for synaptic plasticity and the normal function of the brain. Arc interacts with neuronal postsynaptic proteins, but the mechanistic details of its ... -
Structural similarities and functional differences clarify evolutionary relationships between tRNA healing enzymes and the myelin enzyme CNPase
Muruganandam, Gopinath; Raasakka, Arne; Myllykoski, Matti; Kursula, Inari; Kursula, Petri (Peer reviewed; Journal article, 2017-05-16)Background: Eukaryotic tRNA splicing is an essential process in the transformation of a primary tRNA transcript into a mature functional tRNA molecule. 5′-phosphate ligation involves two steps: a healing reaction catalyzed ... -
Structure and dynamics of a human myelin protein P2 portal region mutant indicate opening of the β barrel in fatty acid binding proteins
Laulumaa, Saara; Nieminen, Tuomo; Raasakka, Arne; Krokengen, Oda C.; Safaryan, Anushik; Hallin, Erik Ingmar; Brysbaert, Guillaume; Lensink, Marc F.; Ruskamo, Salla; Vattulainen, Ilpo; Kursula, Petri (Peer reviewed; Journal article, 2018-06-25)Background: Myelin is a multilayered proteolipid sheath wrapped around selected axons in the nervous system. Its constituent proteins play major roles in forming of the highly regular membrane structure. P2 is a myelin-specific ... -
Structure and function of an atypical homodimeric actin capping protein from the malaria parasite
Bendes, Ábris Ádám; Kursula, Petri; Kursula, Inari (Journal article; Peer reviewed, 2022)Apicomplexan parasites, such as Plasmodium spp., rely on an unusual actomyosin motor, termed glideosome, for motility and host cell invasion. The actin filaments are maintained by a small set of essential regulators, which ... -
Structure and substrate specificity determinants of the taurine biosynthetic enzyme cysteine sulphinic acid decarboxylase
Mahootchi, Elaheh; Raasakk, Arne; Luan, Weisha; Muruganandam, Gopinath; Loris, Remy; Haavik, Jan; Kursula, Petri (Journal article; Peer reviewed, 2021)Pyridoxal 5́-phosphate (PLP) is an important cofactor for amino acid decarboxylases with many biological functions, including the synthesis of signalling molecules, such as serotonin, dopamine, histamine, γ-aminobutyric ... -
Structure of the ALS Mutation Target Annexin A11 Reveals a Stabilising N-Terminal Segment
Lillebostad, Peder August Gudmundsen; Raasakka, Arne; Hjellbrekke, Silje Johannessen; Patil, Sudarshan; Røstbø, Trude Kvalnes; Hollås, Hanne; Sakya, Siri; Szigetvari, Peter Daniel; Vedeler, Anni; Kursula, Petri (Journal article; Peer reviewed, 2020)The functions of the annexin family of proteins involve binding to Ca2+, lipid membranes, other proteins, and RNA, and the annexins share a common folded core structure at the C terminus. Annexin A11 (AnxA11) has a long ... -
Structure of the Complete Dimeric Human GDAP1 Core Domain Provides Insights into Ligand Binding and Clustering of Disease Mutations
Nguyen, Giang Thi Tuyet; Sutinen, Aleksi; Raasakka, Arne; Muruganandam, Gopinath; Loris, Remy; Kursula, Petri (Journal article; Peer reviewed, 2021)Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neurological disorders. Despite the common involvement of ganglioside-induced differentiation-associated protein 1 (GDAP1) in CMT, the protein structure ... -
Structure of the mouse acidic amino acid decarboxylase GADL1
Raasakka, Arne; Mahootchi, Elaheh; Winge, Ingeborg; Luan, Weisha; Kursula, Petri; Haavik, Jan (Journal article; Peer reviewed, 2018)Pyridoxal 5′-phosphate (PLP) is a ubiquitous cofactor in various enzyme classes, including PLP-dependent decarboxylases. A recently discovered member of this class is glutamic acid decarboxylase-like protein 1 (GADL1), ... -
Sub-atomic resolution crystal structures reveal conserved geometric outliers at functional sites
Laulumaa, Saara; Kursula, Petri (Peer reviewed; Journal article, 2019-08-22)Myelin protein 2 (P2) is a peripheral membrane protein of the vertebrate nervous system myelin sheath, having possible roles in both lipid transport and 3D molecular organization of the multilayered myelin membrane. We ...