Blar i Bergen Open Research Archive på forfatter "Reikvam, Håkon"
-
A Patient With Maculopapular Rash and Lichenoid Skin Damage Caused by Ponatinib
Teigen, Ingrid Anna; Sæle, Anna Kristine Myrmel; Reikvam, Håkon (Journal article; Peer reviewed, 2020)Tyrosine kinase inhibitors (TKIs) are invaluable for the treatment of patients with chronic myelogenous leukemia. Although TKIs are generally better tolerated than traditional chemotherapy, dermatologic side effects are ... -
Patients with Bacterial Sepsis Are Heterogeneous with Regard to Their Systemic Lipidomic Profiles
Mosevoll, Knut Anders; Hansen, Bent-Are; Gundersen, Ingunn Margareetta; Reikvam, Håkon; Bruserud, Øyvind; Bruserud, Øystein; Wendelbo, Øystein (Journal article; Peer reviewed, 2023)Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. In the present study, we investigated the systemic/serum lipidomic profile at the time of hospital admission for ... -
Patients with treatment-requiring chronic graft versus host disease after allogeneic stem cell transplantation have altered metabolic profiles due to the disease and immunosuppressive therapy: Potential implication for biomarkers
Reikvam, Håkon; Grønningsæter, Ida Sofie; Mosevoll, Knut Anders; Lindås, Roald; Hatfield, Kimberley Joanne; Bruserud, Øystein (Journal article; Peer reviewed, 2018)Chronic graft versus host disease (cGVHD) is a common long-term complication after allogeneic hematopoietic stem cell transplantation. The objective of our study was to compare the metabolic profiles for allotransplant ... -
The PI3K-Akt-mTOR signaling pathway in human acute myeloid leukemia (AML) cells
Nepstad, Ina; Hatfield, Kimberley Joanne; Grønningsæter, Ida Sofie; Reikvam, Håkon (Journal article; Peer reviewed, 2020)Acute myeloid leukemia (AML) is a heterogeneous group of diseases characterized by uncontrolled proliferation of hematopoietic stem cells in the bone marrow. Malignant cell growth is characterized by disruption of normal ... -
Platelet Microparticles Protect Acute Myelogenous Leukemia Cells against Daunorubicin-Induced Apoptosis
Cacic, Daniel; Reikvam, Håkon; Nordgård, Oddmund; Meyer, Peter; Hervig, Tor (Journal article; Peer reviewed, 2021)The role of platelets in cancer development and progression is increasingly evident, and several platelet–cancer interactions have been discovered, including the uptake of platelet microparticles (PMPs) by cancer cells. ... -
Platelets for advanced drug delivery in cancer
Cacic, Daniel Limi; Hervig, Tor; Reikvam, Håkon (Journal article; Peer reviewed, 2023)Introduction: Cancer-related drug expenses are rising with the increasing cancer incidence and cost may represent a severe challenge for drug access for patients with cancer. Consequently, strategies for increasing therapeutic ... -
The possible importance of β3 integrins for leukemogenesis and chemoresistance in acute myeloid leukemia
Johansen, Silje; Brenner, Annette; Bartaula-Brevik, Sushma; Reikvam, Håkon; Bruserud, Øystein (Peer reviewed; Journal article, 2018-01-15)Acute myeloid leukemia (AML) is an aggressive bone marrow malignancy where the immature leukemia cells communicate with neighboring cells through constitutive cytokine release and through their cell surface adhesion ... -
Preconditioning serum levels of endothelial cell-derived molecules and the risk of posttransplant complications in patients treated with allogeneic stem cell transplantation.
Lindås, Roald; Tvedt, Tor Henrik Anderson; Hatfield, Kimberley Joanne; Reikvam, Håkon; Bruserud, Øystein (Peer reviewed; Journal article, 2014-10-08)Endothelial cells are involved in the pathogenesis of acute graft-versus-host disease (GVHD) after allogeneic stem cell transplantation. These cells express several molecules that can be detected as biologically active ... -
Pretransplant Systemic Lipidomic Profiles in Allogeneic Stem Cell Transplant Recipients
Hatfield, Kimberley Joanne; Bruserud, Øystein; Reikvam, Håkon (Journal article; Peer reviewed, 2022-06-13)Allogeneic stem cell transplantation is used in the treatment of high-risk hematological malignancies. However, this treatment is associated with severe treatment-related morbidity and mortality. The metabolic status of ... -
Pretransplant systemic metabolic profiles in allogeneic hematopoietic stem cell transplant recipients - identification of patient subsets with increased transplant-related mortality
Reikvam, Håkon; Bruserud, Øystein; Hatfield, Kimberley Joanne (Journal article; Peer reviewed, 2023)Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is used in the treatment of high-risk acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS); however, the treatment has high risk of severe ... -
Proteomic Studies of Primary Acute Myeloid Leukemia Cells Derived from Patients Before and during Disease-Stabilizing Treatment Based on All-Trans Retinoic Acid and Valproic Acid
Hernandez-Valladares, Maria; Wangen, Rebecca; Aasebø, Elise; Reikvam, Håkon; Berven, Frode Steingrimsen; Selheim, Frode; Bruserud, Øystein (Journal article; Peer reviewed, 2021)All-trans retinoic acid (ATRA) and valproic acid (VP) have been tried in the treatment of non-promyelocytic variants of acute myeloid leukemia (AML). Non-randomized studies suggest that the two drugs can stabilize AML and ... -
The Regulation of Neutrophil Migration in Patients with Sepsis: The Complexity of the Molecular Mechanisms and Their Modulation in Sepsis and the Heterogeneity of Sepsis Patients
Bruserud, Øystein; Mosevoll, Knut Anders; Bruserud, Øyvind; Reikvam, Håkon; Wendelbo, Øystein (Journal article; Peer reviewed, 2023)Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Common causes include gram-negative and gram-positive bacteria as well as fungi. Neutrophils are among the first ... -
Resistance to the antiproliferative in vitro effect of PI3K-Akt-mTOR inhibition in primary human acute myeloid leukemia cells is associated with altered cell metabolism
Nepstad, Ina; Reikvam, Håkon; Brenner, Annette; Bruserud, Øystein; Hatfield, Kimberley Joanne (Peer reviewed; Journal article, 2018-01-27)Constitutive signaling through the phosphatidylinositol-3-kinase-Akt-mechanistic target of rapamycin (PI3K-Akt-mTOR) pathway is present in acute myeloid leukemia (AML) cells. However, AML is a heterogeneous disease, and ... -
Revisiting the prognostic role of FLT3 mutations in acute myelogenous leukemia
Reikvam, Håkon (Journal article; Peer reviewed, 2023)Introduction: Approximately one-third of patients with acute myelogenous leukemia (AML) harbor mutations in the fms-like tyrosine kinase 3 (FLT3) gene. The features regarding prognostic impact of FLT3 mutated AML have been ... -
Safety of hypoxic red blood cell administration in patients with transfusion-dependent hematological malignancies: An interim analysis
Reikvam, Håkon; Hetland, Geir; Ezligini, Farshid; Dorsch, Kim; Omert, Laurel; Dunham, Andrew; Almeland, Stian Kreken (Journal article; Peer reviewed, 2023)Anemia is a common symptom of hematological malignancies and red blood cell (RBC) transfusion is the primary supportive treatment, with many patients becoming transfusion dependent. Hemanext Inc. (Lexington, MA, United ... -
Spontaneous Splenic Artery Rupture as the First Symptom of Systemic Amyloidosis
Bruserud, Øystein; Tvedt, Tor Henrik Anderson; Ahmed, Aymen B; Vintermyr, Olav Karsten; Hervig, Tor Audun; Guttormsen, Anne Berit; Reikvam, Håkon (Journal article; Peer reviewed, 2021)Spontaneous splenic rupture is a life-threatening condition leading to a rapidly progressing hypovolemic shock due to intra-abdominal blood loss, with a mortality rate of about 10%. Spontaneous splenic rupture can be caused ... -
A subset of patients with acute myeloid leukemia has leukemia cells characterized by chemokine responsiveness and altered expression of transcriptional as well as angiogenic regulators
Brenner, Annette; Reikvam, Håkon; Bruserud, Øystein (Peer reviewed; Journal article, 2016-05-25)Acute myeloid leukemia (AML) is an aggressive and heterogeneous bone marrow malignancy, the only curative treatment being intensive chemotherapy eventually in combination with allogeneic stem cell transplantation. Both the ... -
Surgical Treatment of Severe Bowel Obstruction as a Rare Complication Following Allogenic Hematopoietic Stem Cell Transplantation
Reikvam, Håkon; Tvedt, Tor Henrik Anderson; Johansen, Silje; Setran, Hege Aase; Havre, Roald Flesland (Journal article, 2020)Gastrointestinal graft-versus-host disease (GVHD) and cytomegalovirus (CMV) disease are common complications occurring after allogeneic hematopoietic stem cell transplantation (allo-HSCT), and contribute to a high degree ... -
Systemic levels of the endothelium-derived soluble adhesion molecules endocan and E-selectin in patients with suspected deep vein thrombosis
Mosevoll, Knut Anders; Lindås, Roald; Wendelbo, Øystein; Bruserud, Øystein; Reikvam, Håkon (Peer reviewed; Journal article, 2014-09-30)The initial evaluation of patients with suspected deep vein thrombosis includes the use of biomarkers reflecting activation of the coagulation system. However, the thromboembolic process and neighboring inflammatory responses ... -
Systemic metabolomic profiles in adult patients with bacterial sepsis: Characterization of patient heterogeneity at the time of diagnosis
Mosevoll, Knut Anders; Hansen, Bent-Are; Gundersen, Ingunn Margareetta; Reikvam, Håkon; Bruserud, Øyvind; Bruserud, Øystein; Wendelbo, Øystein (Journal article; Peer reviewed, 2023-01-24)Sepsis is a dysregulated host response to infection that causes potentially life-threatening organ dysfunction. We investigated the serum metabolomic profile at hospital admission for patients with bacterial sepsis. The ...