Browsing Bergen Open Research Archive by Author "Reikvam, Håkon"
Now showing items 61-68 of 68
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Therapeutic targeting the cell division cycle 25 (CDC25) phosphatases in human acute myeloid Leukemia - The possibility to target several kinases through inhibition of the various CDC25 isoforms
Brenner, Annette; Reikvam, Håkon; Lavecchia, Antonio; Bruserud, Øystein (Peer reviewed; Journal article, 2014-11-12)The cell division cycle 25 (CDC25) phosphatases include CDC25A, CDC25B and CDC25C. These three molecules are important regulators of several steps in the cell cycle, including the activation of various cyclin-dependent ... -
Therapeutic use of valproic acid and all-trans retinoic acid in acute myeloid leukemia—literature review and discussion of possible use in relapse after allogeneic stem cell transplantation
Bruserud, Øystein; Tsykunova, Galina; Hernandez-Valladares, Maria; Reikvam, Håkon; Tvedt, Tor Henrik Anderson (Journal article; Peer reviewed, 2021)Even though allogeneic stem cell transplantation is the most intensive treatment for acute myeloid leukemia (AML), chemo-resistant leukemia relapse is still one of the most common causes of death for these patients, as is ... -
Thrombocytopaenia in the critically ill
Bruserud, Øyvind; Mosevoll, Knut Anders; Kristoffersen, Einar Klæboe; Kvåle, Reidar; Reikvam, Håkon (Journal article; Peer reviewed, 2021) -
Thrombosis and thrombocytopenia after HPV vaccination
Johansen, Silje; Lægreid, Ingvild Jenssen; Ernstsen, Siw Leiknes; Azrakhsh, Nessar Ahmad; Kittang, Astrid Marta Olsnes; Lindås, Roald; Gjertsen, Bjørn Tore; Vetti, Nils; Mørtberg, Trude Victoria; Sørvoll, Ingvild Hausberg; Holme, Pål Andre; Ahlen, Maria Therese; Reikvam, Håkon (Journal article; Peer reviewed, 2021)Background Vaccine-induced immune thrombotic thrombocytopenia (VITT) has so far only been reported after adenovirus vector severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines. Objective We report ... -
Toll-like Receptor 4, Osteoblasts and Leukemogenesis; the Lesson from Acute Myeloid Leukemia
Bruserud, Øystein; Reikvam, Håkon; Brenner, Annette (Journal article; Peer reviewed, 2022-01-23)Toll-like receptor 4 (TLR4) is a pattern-recognizing receptor that can bind exogenous and endogenous ligands. It is expressed by acute myeloid leukemia (AML) cells, several bone marrow stromal cells, and nonleukemic cells ... -
Tuberculosis-Associated Hemophagocytic Lymphohistiocytosis: A Review of Current Literature
Fauchald, Trym; Blomberg, Bjørn; Reikvam, Håkon (Journal article; Peer reviewed, 2023)Hemophagocytic lymphohistiocytosis (HLH) is a condition of immune dysregulation and hyperinflammation, leading to organ failure and death. Malignancy, autoimmune conditions, and infections, including Mycobacterium tuberculosis ... -
Vacuolar ATPase Is a Possible Therapeutic Target in Acute Myeloid Leukemia: Focus on Patient Heterogeneity and Treatment Toxicity
Bartaula-Brevik, Sushma; Leitch, Calum; Valladares, Maria del Carmen Hernandez; Aasebø, Elise; Berven, Frode Steingrimsen; Selheim, Frode; Brenner, Annette; Rye, Kristin Paulsen; Hagen, Marie; Reikvam, Håkon; Mc Cormack, Emmet; Bruserud, Øystein; Tvedt, Tor Henrik Anderson (Journal article; Peer reviewed, 2023)Vacuolar ATPase (V-ATPase) is regarded as a possible target in cancer treatment. It is expressed in primary acute myeloid leukemia cells (AML), but the expression varies between patients and is highest for patients with a ... -
Weight gain during treatment course of allogenic hematopoietic stem cell transplantation in patients with hematological malignancies affects treatment outcome
Johansen, Silje; Blomberg, Bjørn; Vo, Anh Khoi; Wendelbo, Øystein; Reikvam, Håkon (Journal article; Peer reviewed, 2022)Background aims Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for patients with hematological malignancies; however, allo-HSCT does not come without the cost of treatment-related ...