• Abundant Genetic Overlap between Blood Lipids and Immune-Mediated Diseases Indicates Shared Molecular Genetic Mechanisms 

      Andreassen, Ole Andreas; Desikan, Rahul S.; Wang, Yunpeng; Thompson, Wesley K.; Schork, Andrew J.; Zuber, Verena; Doncheva, Nadezhda T.; Ellinghaus, E.va; Mattingsdal, Morten; Franke, Andre; Lie, Benedicte. A.; Mills, Ian Geoffrey; Aukrust, Pål; McEvoy, Linda K.; Djurovic, Srdjan; Karlsen, Tom Hemming; Dale, Anders M. (Peer reviewed; Journal article, 2015-04-08)
      Epidemiological studies suggest a relationship between blood lipids and immune-mediated diseases, but the nature of these associations is not well understood. We used genome-wide association studies (GWAS) to investigate ...
    • Attenuated Notch signaling in schizophrenia and bipolar disorder 

      Hoseth, Eva Zsuzsanna; Krull, Florian; Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Gardsjord, Erlend Strand; Steen, Nils Eiel; Melle, Ingrid; Brattbakk, Hans-Richard; Steen, Vidar Martin; Aukrust, Pål; Djurovic, Srdjan; Andreassen, Ole Andreas; Ueland, Thor (Peer reviewed; Journal article, 2018-03-28)
      The Notch signaling pathway plays a crucial role in neurodevelopment and in adult brain homeostasis. We aimed to further investigate Notch pathway activity in bipolar disorder (BD) and schizophrenia (SCZ) by conducting a ...
    • Bariatric surgery reduces fasting total fatty acids and increases n-3 polyunsaturated fatty acids in morbidly obese individuals 

      Hovland, Anders; Nestvold, Torunn Kristin; Bohov, Pavol; Trøseid, Marius; Aukrust, Pål; Berge, Rolf Kristian; Nielsen, Erik Waage; Retterstøl, Kjetil; Lappegård, Knut Tore (Peer reviewed; Journal article, 2017)
      Background: Obesity is a global pandemic leading to increased mortality and increased risk of cardiovascular disease. Bariatric surgery is an established treatment of obesity leading to weight loss and reduction of mortality. ...
    • The carnitine-butyrobetaine-TMAO pathway after cardiac transplant: Impact on cardiac allograft vasculopathy and acute rejection 

      Trøseid, Marius; Mayerhofer, Christiane Caroline; Broch, Kaspar; Arora, Satish; Svardal, Asbjørn M.; Hov, Johannes Espolin Roksund; Andreassen, Arne K.; Gude, Einar; Karason, Kristjan; Dellgren, Gøran; Berge, Rolf Kristian; Gullestad, Lars; Aukrust, Pål; Ueland, Thor (Peer reviewed; Journal article, 2019)
      BACKGROUND: Alterations in the partly microbiota-dependent carnitine–γ-butyrobetaine (γBB)–trimethylamine N-oxide (TMAO) pathway have been linked to the progression of heart failure and atherosclerotic disease. We evaluated ...
    • Cytokine network in adults with falciparum malaria and HIV-1: increased IL-8 and IP-10 levels are associated with disease severity 

      Berg, Åse; Patel, Sam; Gonca, Miguel; Catarina, David; Otterdal, Kari; Ueland, Thor; Dalen, Ingvild; Kvaløy, Jan Terje; Mollnes, Tom Eirik; Aukrust, Pål; Langeland, Nina (Peer reviewed; Journal article, 2014-12-11)
      Background Co-infection with malaria and HIV increases the severity and mortality of both diseases, but the cytokine responses related to this co-infection are only partially characterised. The aim of this study was to ...
    • Effects of interval training on inflammatory biomarkers in patients with ischemic heart failure 

      Isaksen, Kjetil; Halvorsen, Bente; Munk, Peter Scott; Aukrust, Pål; Larsen, Alf Inge (Peer reviewed; Journal article, 2019)
      Objectives. Exercise training has been proposed to have anti-inflammatory effects. We examined whether aerobic interval training (AIT) can attenuate the inflammatory response in ischemic heart failure (HF) as measured by ...
    • Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder 

      Hoseth, Eva Zsuzsanna; Krull, Florian; Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Gardsjord, Erlend Strand; Steen, Nils Eiel; Melle, Ingrid; Brattbakk, Hans-Richard; Steen, Vidar Martin; Aukrust, Pål; Djurovic, Srdjan; Andreassen, Ole Andreas; Ueland, Thor (Peer reviewed; Journal article, 2018)
      The Wnt signaling pathway plays a crucial role in neurodevelopment and in regulating the function and structure of the adult nervous system. Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental disorders with ...
    • High neopterin and IP-10 levels in cerebrospinal fluid are associated with neurotoxic tryptophan metabolites in acute central nervous system infections 

      Quist-Paulsen, Else; Aukrust, Pål; Kran, Anne-Marte Bakken; Dunlop, Oona Borghild; Ormaasen, Vidar; Stiksrud, Birgitte; Midttun, Øivind; Ueland, Thor; Ueland, Per Magne; Mollnes, Tom Eirik; Dyrhol-Riise, Anne Ma (Peer reviewed; Journal article, 2018-11-23)
      Background The host response to intruders in the central nervous system (CNS) may be beneficial but could also be harmful and responsible for neurologic symptoms and sequelae in CNS infections. This immune response induces ...
    • Impact of HIV and type 2 diabetes on gut microbiota diversity, tryptophan catabolism and endothelial dysfunction 

      Hoel, Hedda Benedicte; Hove-Skovsgaard, Malene; Hov, Johannes Espolin Roksund; Gaardbo, Julie Christine; Holm, Kristian; Kummen, Martin; Rudi, Knut; Nwosu, Felix; Valeur, Jørgen; Gelpi, Marco; Seljeflot, Ingebjørg; Ueland, Per Magne; Gerstoft, Jan; Ullum, Henrik; Aukrust, Pål; Nielsen, Susanne Dam; Trøseid, Marius (Peer reviewed; Journal article, 2018-04-30)
      HIV infection and type 2 diabetes are associated with altered gut microbiota, chronic inflammation, and increased cardiovascular risk. We aimed to investigate the combined effect of these diseases on gut microbiota composition ...
    • Impaired HDL function amplifies systemic inflammation in common variable immunodeficiency 

      Macpherson, Magnhild Eide; Halvorsen, Bente; Yndestad, Arne; Ueland, Thor; Mollnes, Tom Eirik; Berge, Rolf Kristian; Rashidi, Azita; Otterdal, Kari; Gregersen, Ida; Kong, Xiang Yi; Holven, Kirsten Bjørklund; Aukrust, Pål; Fevang, Børre; Jørgensen, Silje Fjellgård (Peer reviewed; Journal article, 2019-07-01)
      Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency, characterized by inadequate antibody responses and recurrent bacterial infections. Paradoxically, a majority of CVID patients ...
    • Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19 

      Jørgensen, Marthe Jøntvedt; Holter, Jan Cato; Christensen, Erik; Schjalm, Camilla; Tonby, Kristian; Pischke, Soeren; Jenum, Synne; Skeie, Linda Gail; Nur, Sarah; Lind, Andreas; Opsand, Hanne; Enersen, Tone Burvald; Grøndahl, Ragnhild; Hermann, Anne; Dudman, Susanne Gjeruldsen; Müller, Fredrik; Ueland, Thor; Mollnes, Tom Eirik; Aukrust, Pål; Heggelund, Lars; Holten, Aleksander Rygh; Dyrhol-Riise, Anne Ma (Journal article; Peer reviewed, 2020-12)
      In SARS-CoV-2 infection there is an urgent need to identify patients that will progress to severe COVID-19 and may benefit from targeted treatment. In this study we analyzed plasma cytokines in COVID-19 patients and ...
    • Increased severity and mortality in adults co-infected with malaria and HIV in Maputo, Mozambique: a prospective cross-sectional study 

      Berg, Åse; Patel, Sam; Aukrust, Pål; David, Catarina; Gonca, Miguel; Berg, Einar Sverre; Dalen, Ingvild; Langeland, Nina (Peer reviewed; Journal article, 2014-02-05)
      Background: Co-infection with falciparum malaria and HIV-1 increases the severity and mortality of both infections in unstable malaria-transmission areas. In contrast, in stable transmission areas, HIV co-infection increases ...
    • Inflammation markers in multiple sclerosis: CXCL16 reflects and may also predict disease activity 

      Holmøy, Trygve; Løken-Amsrud, Kristin Ingeleiv; Bakke, Jacob; Beiske, Antonie Giæver; Bjerve, Kristian S; Hovdal, Harald Olav; Lilleås, Finn; Midgard, Rune; Pedersen, Tom; Saltyte Benth, Jurate; Torkildsen, Øivind; Wergeland, Stig; Myhr, Kjell-Morten; Michelsen, Annika; Aukrust, Pål; Ueland, Thor (Peer reviewed; Journal article, 2013-09-19)
      Background. Serum markers of inflammation are candidate biomarkers in multiple sclerosis (MS). ω-3 fatty acids are suggested to have anti-inflammatory properties that might be beneficial in MS. We aimed to explore the ...
    • IP-10 differentiates between active and latent tuberculosis irrespective of HIV status and declines during therapy 

      Wergeland, Ida; Pullar, Nadine Durema; Assmus, Jörg; Ueland, Thor; Tonby, Kristian; Feruglio, Siri; Kvale, Dag; Damås, Jan Kristian; Aukrust, Pål; Mollnes, Tom Eirik; Dyrhol-Riise, Anne Ma (Peer reviewed; Journal article, 2015-04)
      Objectives: Biomarkers for diagnosis and therapy efficacy in tuberculosis (TB) are requested. We have studied biomarkers that may differentiate between active and latent TB infection (LTBI), the influence of HIV infection ...
    • Krill oil attenuates left ventricular dilatation after myocardial infarction in rats 

      Fosshaug, Linn Elisabeth; Berge, Rolf Kristian; Beitnes, Jan Otto; Berge, Kjetil; Vik, Hogne; Aukrust, Pål; Gullestad, Lars; Vinge, Leif Erik; Øie, Erik (Peer reviewed; Journal article, 2011-12-29)
      Background: In the western world, heart failure (HF) is one of the most important causes of cardiovascular mortality. Supplement with n-3 polyunsaturated fatty acids (PUFA) has been shown to improve cardiac function in HF ...
    • NLRP3 inflammasome promotes myocardial remodeling during diet-induced obesity 

      Sokolova, Marina; Sjaastad, Ivar; Louwe, Maria Cornelia; Alfsnes, Katrine; Aronsen, Jan Magnus; Zhang, Lili; Haugstad, Solveig Bjærum; Bendiksen, Bård Andre; Øgaard, Jonas; Bliksøen, Marte; Lien, Egil; Berge, Rolf Kristian; Aukrust, Pål; Ranheim, Trine; Yndestad, Arne (Peer reviewed; Journal article, 2019-07-16)
      Background: Obesity is an increasingly prevalent metabolic disorder in the modern world and is associated with structural and functional changes in the heart. The NLRP3 inflammasome is an innate immune sensor that can be ...
    • Plasma tumour necrosis factor correlates with mRNA expression of tumour necrosis factor and mitochondrial transcription factors in skeletal muscle in patients with chronic heart failure treated with cardiac resynchronization therapy: potential role in myopathy 

      Larsen, Alf Inge; Valborgland, Torstein; Ogne, Christer; Lindal, Sigurd; Halvorsen, Bente; Munk, Peter Scott; Kvaløy, Jan Terje; Aukrust, Pål; Yndestad, Arne (Peer reviewed; Journal article, 2019)
      Chronic heart failure (CHF) is characterized by inflammation and skeletal muscle myopathy, including impaired fibre type distribution and reduced capillary density, reduced cytochrome oxidase activity and reduced mitochondrial ...
    • Predictors of exacerbations in chronic obstructive pulmonary disease - results from the Bergen COPD Cohort Study 

      Husebø, Gunnar Reksten; Bakke, Per; Aanerud, Marianne; Hardie, Jon Andrew; Ueland, Thor; Grønseth, Rune; Persson, Louise Jeanette Pauline; Aukrust, Pål; Eagan, Tomas Mikal (Peer reviewed; Journal article, 2014-10-03)
      Background: COPD exacerbations accelerate disease progression. Aims To examine if COPD characteristics and systemic inflammatory markers predict the risk for acute COPD exacerbation (AECOPD) frequency and duration. Methods: ...
    • Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency 

      Jørgensen, Silje Fjellgård; Macpherson, Magnhild Eide; Bjørnetrø, Tonje; Holm, Kristian; Kummen, Martin; Rashidi, Azita; Michelsen, Annika; Lekva, Tove; Halvorsen, Bente; Trøseid, Marius; Mollnes, Tom Eirik; Berge, Rolf Kristian; Yndestad, Arne; Ueland, Thor; Karlsen, Tom Hemming; Aukrust, Pål; Hov, Johannes Espolin Roksund; Fevang, Børre (Peer reviewed; Journal article, 2019-01-17)
      Common variable immunodefciency (CVID) patients have reduced gut microbial diversity compared to healthy controls. The reduced diversity is associated with gut leakage, increased systemic infammation and ten “key” bacteria ...
    • Risk factors for lung cancer in COPD - results from the Bergen COPD cohort study 

      Husebø, Gunnar; Nielsen, Rune; Hardie, Jon Andrew; Bakke, Per S.; Lerner, Lorena; D'Alessandro-Gabazza, Corina; Gyuris, Jeno; Gabazza, Esteban; Aukrust, Pål; Eagan, Tomas Mikal (Peer reviewed; Journal article, 2019)
      Background: COPD patients have an increased risk of developing lung cancer, but the underlying mechanisms are poorly understood. We aimed to identify risk factors for lung cancer in patients from the Bergen COPD Cohort ...