Browsing Bergen Open Research Archive by Author "Azuaje, Francisco"

Now showing items 1-5 of 5

    • Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis 

      Sundstrøm, Terje; Prestegarden, Lars; Azuaje, Francisco; Aasen, Synnøve Nymark; Røsland, Gro Vatne; Varughese, Jobin K.; Bahador, Marzieh; Bernatz, Simon; Braun, Yannick; Harter, Patrick N.; Skaftnesmo, Kai Ove; Ingham, Elizabeth S.; Mahakian, Lisa M.; Tam, Sarah; Tepper, Clifford G.; Petersen, Kjell; Ferrara, Katherine W.; Tronstad, Karl Johan; Lund-Johansen, Morten; Beschorner, Rudi; Bjerkvig, Rolf; Thorsen, Frits (Peer reviewed; Journal article, 2019-04-10)
      Melanoma patients carry a high risk of developing brain metastases, and improvements in survival are still measured in weeks or months. Durable disease control within the brain is impeded by poor drug penetration across ...

    • Oncolytic H-1 parvovirus binds to sialic acid on laminins for cell attachment and entry 

      Kulkarni, Amit; Ferreira, Tiago; Bretscher, Clemens; Grewenig, Annabel; El-Andaloussi, Nazim; Bonifati, Serena; Marttila, Tiina; Palissot, Valèrie; Hossain, Jubayer A.; Azuaje, Francisco; Miletic, Hrvoje; Ystaas, Lars Andreas Rømo; Golebiewska, Anna; Niclou, Simone Pierrette; Roeth, Ralf; Niesler, Beate; Weiss, Amélie; Brino, Laurent; Marchini, Antonio (Journal article; Peer reviewed, 2021)
      H-1 parvovirus (H-1PV) is a promising anticancer therapy. However, in-depth understanding of its life cycle, including the host cell factors needed for infectivity and oncolysis, is lacking. This understanding may guide ...

    • Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology 

      Golebiewska, Anna; Hau, Ann-Christin; Oudin, Anaïs; Stieber, Daniel; Yabo, Yahaya A.; Baus, Virginie; Barthelemy, Vanessa; Klein, Eliane; Bougnaud, Sébastien; Keunen, Olivier; Wantz, May; Michelucci, Alessandro; Neirinckx, Virginie; Muller, Arnaud; Kaoma, Tony; Nazarov, Petr V.; Azuaje, Francisco; De Falco, Alfonso; Flies, Ben; Richart, Lorraine; Poovathingal, Suresh K; Arns, Thais; Grzyb, Kamil; Mock, Andreas; Herold-Mende, Christel; Steino, Anne; Brown, Dennis; May, Patrick; Miletic, Hrvoje; Malta, Tathiane M.; Noushmehr, Houtan; Kwon, Yong-Jun; Jahn, Winnie; Klink, Barbara; Tanner, Georgette; Stead, Lucy F.; Mittelbronn, Michel; Skupin, Alexander; Hertel, Frank; Bjerkvig, Rolf; Niclou, Simone Pierrette (Journal article; Peer reviewed, 2020)
      Patient-based cancer models are essential tools for studying tumor biology and for the assessment of drug responses in a translational context. We report the establishment a large cohort of unique organoids and patient-derived ...

    • Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment 

      Dirkse, Anna; Golebiewska, Anna; Buder, Thomas; Nazarov, Petr V.; Muller, Arnaud; Poovathingal, Suresh K.; Brons, Nicolaas H. C.; Leite, Sonia; Sauvageot, Nicolas; Sarkisjan, Dzjemma; Seyfrid, Mathieu; Fritah, Sabrina; Stieber, Daniel; Michelucci, Alesandro; Hertel, Frank; Herold-Mende, Christel; Azuaje, Francisco; Skupin, Alexander; Bjerkvig, Rolf; Deutsch, Andreas; Voss-Böhme, Anja; Niclou, Simone Pierrette (Peer reviewed; Journal article, 2019-04-16)
      The identity and unique capacity of cancer stem cells (CSC) to drive tumor growth and resistance have been challenged in brain tumors. Here we report that cells expressing CSC-associated cell membrane markers in Glioblastoma ...

    • Temozolomide-induced rna interactome uncovers novel lncrna regulatory loops in glioblastoma 

      Fritah, Sabrina; Muller, Arnaud; Jiang, Wei; Mitra, Ramkrishna; Sarmini, Mohamad; Dieterle, Monika; Golebiewska, Anna; Ye, Tao; van Dyck, Eric; Herold-Mende, Christel; Zhao, Zhongming; Azuaje, Francisco; Niclou, Simone Pierrette (Journal article; Peer reviewed, 2020-09-10)
      Resistance to chemotherapy by temozolomide (TMZ) is a major cause of glioblastoma (GBM) recurrence. So far, attempts to characterize factors that contribute to TMZ sensitivity have largely focused on protein-coding genes, ...