Blar i Bergen Open Research Archive på forfatter "Bernd, August"
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Increased plasma colloid osmotic pressure facilitates the uptake of therapeutic macromolecules in a xenograft tumour model
Hofmann, Matthias; McCormack, Emmet; Mujic, Maja; Roßberg, Maila; Bernd, August; Bereiter-Hahn, Jürgen; Gjertsen, Bjørn Tore; Wiig, Helge; Kippenberger, Stefan (Peer reviewed; Journal article, 2009-08)Elevated tumor interstitial fluid pressure (TIFP) is a characteristic of most solid tumors. Clinically, TIFP may hamper the uptake of chemotherapeutic drugs into the tumor tissue reducing their therapeutic efficacy. In ... -
Lowering of tumor interstitial fluid pressure reduces tumor cell proliferation in a xenograft tumor model
Hofmann, Matthias; Guschel, Maike; Bernd, August; Bereiter-Hahn, Jürgen; Kaufmann, Robert; Tandi, Christa; Wiig, Helge; Kippenberger, Stefan (Peer reviewed; Journal article, 2006-02)High tumor interstitial fluid pressure (TIFP) is a characteristic of most solid tumors. TIFP may hamper adequate uptake of macromolecular therapeutics in tumor tissue. In addition, TIFP generates mechanical forces affecting ...