Browsing Bergen Open Research Archive by Author "Bjørndal, Bodil"
Now showing items 1-20 of 29
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A chicken protein hydrolysate exerts anti-atherosclerotic effect beyond plasma cholesterol-lowering activity in Apoe−/− mice
Bjørndal, Bodil; Aloysius, Thomas Aquinas; Lund, Anders; Slizyte, Rasa; Bohov, Pavol; Carvajal, Ana Karina; Berge, Rolf Kristian (Peer reviewed; Journal article, 2019-01-13)Chicken protein hydrolysates (CPHs) generated from rest raw materials through enzymatic hydrolysis using Corolase PP or Alcalase were shown to reduce inflammation and stimulate hepatic mitochondrial fatty acid oxidation ... -
Dietary intake of n-3 long-chain polyunsaturated fatty acids and risk of myocardial infarction in coronary artery disease patients with or without diabetes mellitus: a prospective cohort study
Strand, Elin; Pedersen, Eva Kristine Ringdal; Svingen, Gard Frodahl Tveitevåg; Schartum-Hansen, Hall; Rebnord, Eirik Wilberg; Bjørndal, Bodil; Seifert, Reinhard; Bohov, Pavol; Meyer, Klaus; Hiltunen, J. Kalervo; Nordrehaug, Jan Erik; Nilsen, Dennis W. T.; Berge, Rolf Kristian; Nygård, Ottar (Peer reviewed; Journal article, 2013-10-08)Background: A beneficial effect of a high n-3 long-chain polyunsaturated fatty acid (LCPUFA) intake has been observed in heart failure patients, who are frequently insulin resistant. We investigated the potential influence ... -
Fish oil and krill oil differentially modify the liver and brain lipidome when fed to mice
Skorve, Jon; Hilvo, Mika; Vihervaara, Terhi; Burri, Lena; Bohov, Pavol; Tillander, Veronika; Bjørndal, Bodil; Suoniemi, Matti; Laaksonen, Reijo; Ekroos, Kim; Berge, Rolf Kristian; Alexson, Stefan E.H. (Peer reviewed; Journal article, 2015-08-11)Background: Marine food is an important source of omega-3 fatty acids with beneficial health effects. Oils from marine organisms have different fatty acid composition and differ in their molecular composition. Fish oil ... -
Fish oil and krill oil supplementations differentially regulate lipid catabolic and synthetic pathways in mice
Tillander, Veronika; Bjørndal, Bodil; Burri, Lena; Bohov, Pavol; Skorve, Jon; Berge, Rolf Kristian; Alexson, Stefan E. H. (Peer reviewed; Journal article, 2014-04-27)Background: Marine derived oils are rich in long-chain polyunsaturated omega-3 fatty acids, in particular eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which have long been associated with health promoting ... -
A fish protein hydrolysate alters fatty acid composition in liver and adipose tissue and increases plasma carnitine levels in a mouse model of chronic inflammation
Bjørndal, Bodil; Berge, Christ; Ramsvik, Marie Sannes; Svardal, Asbjørn; Bohov, Pavol; Skorve, Jon; Berge, Rolf Kristian (Peer reviewed; Journal article, 2013-10-07)Background: There is growing evidence that fish protein hydrolysate (FPH) diets affect mitochondrial fatty acid metabolism in animals. The aim of the study was to determine if FPH could influence fatty acid metabolism and ... -
Krill oil reduces plasma triacylglycerol level and improves related lipoprotein particle concentration, fatty acid composition and redox status in healthy young adults - a pilot study
Berge, Rolf Kristian; Ramsvik, Marie Sannes; Bohov, Pavol; Svardal, Asbjørn; Nordrehaug, Jan Erik; Rostrup, Espen; Bruheim, Inge; Bjørndal, Bodil (Peer reviewed; Journal article, 2015-12-15)Background: Lipid abnormalities, enhanced inflammation and oxidative stress seem to represent a vicious circle in atherogenesis, and therapeutic options directed against these processes seems like a reasonable approach in ... -
Lipid, fatty acid, carnitine- and choline derivative profiles in rheumatoid arthritis outpatients with different degrees of periodontal inflammation
Beyer, Kathrin; Lie, Stein Atle; Bjørndal, Bodil; Berge, Rolf K.; Svardal, Asbjørn M.; Brun, Johan G.; Bolstad, Anne Isine (Journal article; Peer reviewed, 2021)Rheumatoid arthritis (RA) and periodontitis are chronic inflammatory diseases with several pathogenic pathways in common. Evidence supports an association between the diseases, but the exact underlying mechanisms behind ... -
Lipid-Lowering Effects of Tetradecylthioacetic Acid in Antipsychotic-Exposed, Female Rats: Challenges with Long-Term Treatment
Skrede, Silje; Fernø, Johan; Bjørndal, Bodil; Brede, Wenche Rødseth; Bohov, Pavol; Berge, Rolf Kristian; Steen, Vidar Martin (Peer reviewed; Journal article, 2012-11-30)Background: Psychiatric patients often require chronic treatment with antipsychotic drugs, and while rats are frequently used to study antipsychotic-induced metabolic adverse effects, long-term exposure has only partially ... -
Long-term treatment with the pan-PPAR agonist tetradecylthioacetic acid or fish oil is associated with increased cardiac content of n-3 fatty acids in rat
Strand, Elin; Bjørndal, Bodil; Nygård, Ottar; Burri, Lena; Berge, Christ; Bohov, Pavol; Christensen, Bjørn Jostein; Berge, Kjetil; Wergedahl, Hege; Viste, Asgaut; Berge, Rolf Kristian (Peer reviewed; Journal article, 2012-06-27)Background: Excess peroxisome proliferator-activated receptor (PPAR) stimulation has been associated with detrimental health effects including impaired myocardial function. Recently, supplementation with n-3 polyunsaturated ... -
A mitochondria-targeted fatty acid analogue influences hepatic glucose metabolism and reduces the plasma insulin/glucose ratio in male Wistar rats
Lindquist, Carine; Bjørndal, Bodil; Bakke, Hege Gilbø; Slettom, Grete; Karoliussen, Marie; Rustan, Arild; Thoresen, G. Hege; Skorve, Jon; Nygård, Ottar; Berge, Rolf Kristian (Peer reviewed; Journal article, 2019-09-24)A fatty acid analogue, 2-(tridec-12-yn-1-ylthio)acetic acid (1-triple TTA), was previously shown to have hypolipidemic effects in rats by targeting mitochondrial activity predominantly in liver. This study aimed to determine ... -
Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice
Skarpengland, Tonje; Holm, Sverre; Scheffler, Katja; Gregersen, Ida; Dahl, Tuva Børresdatter; Suganthan, Rajikala; Segers, Filip; Østlie, Ingunn; Otten, Jeroen J.T.; Gomez, Luisa Fernanda Luna; Ketelhuth, Daniel F.J.; Lundberg, Anna M.; Neurauter, Christine Gran; Hildrestrand, Gunn Annette; Skjelland, Mona; Bjørndal, Bodil; Svardal, Asbjørn M.; Iversen, Per Ole; Hedin, Ulf; Nygård, Ståle; Olstad, Ole Kristoffer; Krohg-Sørensen, Kirsten; Slupphaug, Geir; Eide, Lars; Kusnierczyk, Anna; Folkersen, Lasse; Ueland, Thor; Berge, Rolf Kristian; Hansson, Göran K.; Biessen, Erik A.L.; Halvorsen, Bente; Bjørås, Magnar; Aukrust, Pål (Journal article; Peer reviewed, 2016)Increasing evidence suggests that oxidative DNA damage accumulates in atherosclerosis. Recently, we showed that a genetic variant in the human DNA repair enzyme NEIL3 was associated with increased risk of myocardial ... -
Peroxisome Proliferator-Activated Receptor Activation is Associated with Altered Plasma One-Carbon Metabolites and B-Vitamin Status in Rats
Lysne, Vegard; Strand, Elin; Svingen, Gard Frodahl Tveitevåg; Bjørndal, Bodil; Pedersen, Eva Ringdal; Midttun, Øivind; Olsen, Thomas; Ueland, Per Magne; Berge, Rolf Kristian; Nygård, Ottar (Peer reviewed; Journal article, 2016-01-05)Plasma concentrations of metabolites along the choline oxidation pathway have been linked to increased risk of major lifestyle diseases, and peroxisome proliferator-activated receptors (PPARs) have been suggested to be ... -
A Phospholipid-Protein Complex from Antarctic Krill Reduced Plasma Homocysteine Levels and Increased Plasma Trimethylamine-N-Oxide (TMAO) and Carnitine Levels in Male Wistar Rats
Bjørndal, Bodil; Ramsvik, Marie Sannes; Lindquist, Carine; Nordrehaug, Jan Erik; Bruheim, Inge; Svardal, Asbjørn M.; Nygård, Ottar; Berge, Rolf Kristian (Peer reviewed; Journal article, 2015-09-08)Seafood is assumed to be beneficial for cardiovascular health, mainly based on plasma lipid lowering and anti-inflammatory effects of n-3 polyunsaturated fatty acids. However, other plasma risk factors linked to cardiovascular ... -
A phospholipid-protein complex from krill with antioxidative and immunomodulating properties reduced plasma triacylglycerol and hepatic lipogenesis in rats
Ramsvik, Marie Sannes; Bjørndal, Bodil; Bruheim, Inge; Bohov, Pavol; Berge, Rolf Kristian (Peer reviewed; Journal article, 2015-07-16)Dietary intake of marine omega-3 polyunsaturated fatty acids (n-3 PUFAs) can change the plasma profile from atherogenic to cardioprotective. In addition, there is growing evidence that proteins of marine origin may have ... -
Phospholipids from herring roe improve plasma lipids and glucose tolerance in healthy, young adults
Bjørndal, Bodil; Strand, Elin; Gjerde, Jennifer; Bohov, Pavol; Svardal, Asbjørn; Diehl, Bernd W. K.; Innis, Sheila M.; Berger, Alvin; Berge, Rolf Kristian (Peer reviewed; Journal article, 2014-05-17)Background: Herring roe is an underutilized source of n-3 polyunsaturated fatty acids (PUFAs) for human consumption with high phospholipid (PL) content. Studies have shown that PL may improve bioavailability of n-3 PUFAs. ... -
Plasma 3-hydroxyisobutyrate (3-HIB) and methylmalonic acid (MMA) are markers of hepatic mitochondrial fatty acid oxidation in male Wistar rats
Nilsen, Mona Synnøve; Lindquist, Carine; Stafsnes, Marit Hallvardsdotter; Bjørndal, Bodil; Bruheim, Per; Aloysius, Thomas Aquinas; Nygård, Ottar; Skorve, Jon; Madsen, Lise; Dankel, Simon N; Berge, Rolf Kristian (Journal article; Peer reviewed, 2021)Objective Discovery of specific markers that reflect altered hepatic fatty acid oxidation could help to detect an individual's risk of fatty liver, type 2 diabetes and cardiovascular disease at an early stage. Lipid and ... -
The PPAR pan-agonist tetradecylthioacetic acid promotes redistribution of plasma cholesterol towards large HDL
Lundåsen, Thomas; Pedrelli, Matteo; Bjørndal, Bodil; Rozell, Björn; Kuiper, Raoul; Burri, Lena; Pavanello, Chiara; Turri, Marta; Skorve, Jon; Berge, Rolf Kristian; Alexson, Stefan E.H.; Tillander, Veronika (Journal article; Peer reviewed, 2020)Tetradecylthioacetic acid (TTA) is a synthetic fatty acid with a sulfur substitution in the β-position. This modification renders TTA unable to undergo complete β-oxidation and increases its biological activity, including ... -
A protein extract from chicken reduces plasma homocysteine in rats
Lysne, Vegard; Bjørndal, Bodil; Vik, Rita; Nordrehaug, Jan Erik; Skorve, Jon; Nygård, Ottar; Berge, Rolf Kristian (Peer reviewed; Journal article, 2015-06-04)The present study aimed to evaluate effects of a water-soluble protein fraction of chicken (CP), with a low methionine/glycine ratio, on plasma homocysteine and metabolites related to homocysteine metabolism. Male Wistar ... -
A randomized, double-blind, placebo-controlled clinical study to investigate the efficacy of herring roe oil for treatment of psoriasis
Tveit, Kåre Steinar; Brokstad, Karl Albert; Berge, Rolf Kristian; Sæbø, Per Christian; Hallaråker, Hogne; Brekke, Stian; Meland, Nils; Bjørndal, Bodil (Journal article; Peer reviewed, 2020-05-07)The effect of omega-3 polyunsaturated fatty acid supplements in patients with psoriasis vulgaris has previously been investigated, but interventions varied in source, composition, dose, administration route and duration ... -
Receptor for activated C-kinase (RACK1) plays a central role in Ras-mediated signal transduction
Lillehaug, Johan; Myklebust, Line Merethe; Raae, Arnt Johan; Bjørndal, Bodil (Conference object; Peer reviewed, 2010-09-24)