Browsing Bergen Open Research Archive by Author "Bjune, Gunnar Aksel"
Now showing items 1-6 of 6
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Evidence for waning of latency in a cohort study of tuberculosis
Wiker, Harald G.; Mustafa, Tehmina; Bjune, Gunnar Aksel; Harbo, Morten (Peer reviewed; Journal article, 2010-02-23)Background To investigate how the risk of active tuberculosis disease is influenced by time since original infection and to determine whether the risk of reactivation of tuberculosis increases or decreases with age. Methods ... -
In Situ Expression of Cytokines and Cellular Phenotypes in the Lungs of Mice with Slowly Progressive Primary Tuberculosis
Mustafa, Tehmina; Phyu, S.; Nilsen, Rune; Jonsson, Roland; Bjune, Gunnar Aksel (Peer reviewed; Journal article, 2000-06)The cellular phenotypes and the expression of cytokines were studied in the lungs of mice, using immunohistochemistry, during different phases of slowly progressive primary murine tuberculosis infection. During the first ... -
Increased Expression of Fas Ligand in Human Tuberculosis and Leprosy Lesions: a Potential Novel Mechanism of Immune Evasion in Mycobacterial Infection
Mustafa, Tehmina; Bjune, Gunnar Aksel; Jonsson, Roland; Pando, R. Hernandez; Nilsen, Rune (Peer reviewed; Journal article, 2001-12)To study the location and mechanism of apoptosis within the human tuberculosis (TB) and leprosy lesions, parallel sections were analyzed for mycobacterial antigens (M.Ag), Fas ligand (FasL), Fas, CD68 and Mac387 by ... -
A Mouse Model for Latent Tuberculosis
Phyu, S.; Mustafa, Tehmina; Hofstad, T.; Nilsen, Rune; Fosse, R.; Bjune, Gunnar Aksel (Peer reviewed; Journal article, 1998-06)The aim of the study was to establish a reproducible murine model for latent tuberculosis. We propose an operational definition of latent murine tuberculosis as a stable Mycobacterium tuberculosis count in lungs and spleens ... -
A Mouse Model for Slowly Progressive Primary Tuberculosis
Mustafa, Tehmina; Phyu, S.; Nilsen, Rune; Jonsson, Roland; Bjune, Gunnar Aksel (Journal article, 1999-08)The progression from primary Mycobacterium tuberculosis infection to disease is usually slow in humans. The aim of this study was to develop and characterize a mouse model for slowly progressive primary tuberculosis, using ... -
Mycobacterial antigens accumulation in foamy macrophages in murine pulmonary tuberculosis lesions: Association with necrosis and making of cavities
Riaz, Syeda Mariam; Bjune, Gunnar Aksel; Wiker, Harald G; Sviland, Lisbeth; Mustafa, Tehmina (Journal article; Peer reviewed, 2020)Understanding mechanisms of cavitation in tuberculosis (TB) is the missing link that could advance the field towards better control of the infection. Descriptions of human TB suggest that postprimary TB begins as lipid ...