• norsk
    • English
  • norsk 
    • norsk
    • English
  • Logg inn
Vis innførsel 
  •   Hjem
  • Faculty of Medicine
  • Department of Global Public Health and Primary Care
  • Department of Global Public Health and Primary Care
  • Vis innførsel
  •   Hjem
  • Faculty of Medicine
  • Department of Global Public Health and Primary Care
  • Department of Global Public Health and Primary Care
  • Vis innførsel
JavaScript is disabled for your browser. Some features of this site may not work without it.

In Situ Expression of Cytokines and Cellular Phenotypes in the Lungs of Mice with Slowly Progressive Primary Tuberculosis

Mustafa, Tehmina; Phyu, S.; Nilsen, Rune; Jonsson, Roland; Bjune, Gunnar Aksel
Peer reviewed, Journal article
Thumbnail
Åpne
Article_SJI_51(16).pdf (377.6Kb)
Permanent lenke
https://hdl.handle.net/1956/2065
Utgivelsesdato
2000-06
Metadata
Vis full innførsel
Samlinger
  • Department of Clinical Dentistry [353]
  • Department of Global Public Health and Primary Care [2508]
Originalversjon
https://doi.org/10.1046/j.1365-3083.2000.00721.x
Sammendrag
The cellular phenotypes and the expression of cytokines were studied in the lungs of mice, using immunohistochemistry, during different phases of slowly progressive primary murine tuberculosis infection. During the first phase the small focal lesions in healthy mice contained predominantly interleukin-2 (IL-2)- expressing cells. A small number of tumour necrosis factor-a (TNF-a)-, monocyte chemoattractant protein-1 (MCP-1)- and IL-10-expressing cells were also present. IL-4-expressing cells were not detected. During the second phase the mice became unwell, but the bacterial counts and the size of focal lesions stabilized. IL-4- expressing cells appeared. The IL-10-, TNF-a- and MCP-1-expressing cells increased in number. On progression to phase three, the mice became seriously unwell and died rapidly. The inflammation spread to <80% of the lung parenchyma. There was a marked increase in the number of IL-10-expressing cells. Expression of other cytokines was similar to that observed in the second phase. In the lesions, 3±6% of the macrophages (Mf) containing mycobacterial antigens expressed high levels of IL-10 and TNF-a. The absolute numbers of CD3-, CD4- and CD11b-expressing cells in the lesions increased with the progression of infection. The numbers of CD8+ cells were reduced in the last phase of infection. The kinetics of T-lymphocyte subsets and the pattern of cytokine expression changed with the type and degree of tissue injury. The small number of Mf with a heavy load of mycobacterial antigens may be the cause of this disturbance in cytokine balance, thus leading to progression of inflammation.
Utgiver
Blackwell Science Ltd.
Opphavsrett
Copyright 2000 Blackwell Science Ltd

Kontakt oss | Gi tilbakemelding

Personvernerklæring
DSpace software copyright © 2002-2019  DuraSpace

Levert av  Unit
 

 

Bla i

Hele arkivetDelarkiv og samlingerUtgivelsesdatoForfattereTitlerEmneordDokumenttyperTidsskrifterDenne samlingenUtgivelsesdatoForfattereTitlerEmneordDokumenttyperTidsskrifter

Min side

Logg inn

Statistikk

Besøksstatistikk

Kontakt oss | Gi tilbakemelding

Personvernerklæring
DSpace software copyright © 2002-2019  DuraSpace

Levert av  Unit