Recent Submissions

  • Use of sildenafil and other phosphodiesterase type 5 inhibitors among pregnant women in Scandinavia 

    Cesta, Carolyn E.; Segovia Chacón, Silvia; Engeland, Anders; Broe, Anne; Damkier, Per; Furu, Kari; Kieler, Helle; Karlsson, Pär (Journal article; Peer reviewed, 2021)
    Introduction For phosphodiesterase type 5 (PDE5) inhibitors, such as sildenafil, the only approved indication in women is for pulmonary arterial hypertension. These drugs are increasingly being proposed and tested for ...
  • Challenges and possible solutions in cross-disciplinary and cross-sectorial research teams within the domain of e-mental health 

    Nordgreen, Tine; Rabbi, Fazle; Tørresen, Jim; Skar, Yngvar Sigmund; Guribye, Frode; Inal, Yavuz; Flobak, Eivind; Wake, Jo Dugstad; Mukhiya, Suresh Kumar; Aminifar, Amin; Myklebost, Sunniva Brurok; Lundervold, Astri J.; Kenter, Robin Maria Francisca; Hammar, Åsa Karin; Kahlon, Smiti; Nordby, Emilie; Sekse, Ragnhild Johanne Tveit; Griffin, Kristine Fonnes; Jakobsen, Petter; Pham, Hoang Minh; Côté-Allard, Ulysse Teller Masao; Noori, Farzan Majeed; Lamo, Yngve (Journal article; Peer reviewed, 2021)
    Purpose: Mental illness presents a huge individual, societal and economic challenges, currently accounting for 20% of the worldwide burden of disease. There is a gap between the need for and access to services. Digital ...
  • A whole blood based resuscitation strategy in civilian medical services: Experience from a Norwegian hospital in the period 2017–2020 

    Hagen, Kristin Gjerde; Strandenes, Geir; Kristoffersen, Einar Klæboe; Braathen, Hanne; Sivertsen, Joar; Bjerkvig, Christopher Kalhagen; Sommerfelt-Pettersen, Nina Grindheim; Aasheim, Irmelin Beathe; Lunde, Turid Helen Felli; Hervig, Tor; Apelseth, Torunn Oveland (Journal article; Peer reviewed, 2021)
    Background: Civilian and military guidelines recommend early balanced transfusion to patients with life-threatening bleeding. Low titer group O whole blood was introduced as the primary blood product for resuscitation of ...
  • EUS-guided gastroenterostomy with a lumen apposing self-expandable metallic stent relieves gastric outlet obstruction–a Scandinavian case series 

    Havre, Roald Flesland; Dai, C.; Roug, Stine; Novovic, Srdan; Schmidt, P.N.; Feldager, E.; Karstensen, J.G.; Pham, Khanh Do-Cong (Journal article; Peer reviewed, 2021)
    Background: EUS-guided gastroenterostomy (EUS-GE) with lumen-apposing metallic stents (LAMS) in patients with gastric outlet obstruction (GOO) has proven to be an alternative to luminal stenting in the duodenum and surgical ...
  • Temperature-dependent autoactivation associated with clinical variability of PDGFRB Asn666 substitutions 

    Bredrup, Cecilie; Cristea, Ileana; Safieh, Leen Abu; Di Maria, Emilio; Gjertsen, Bjørn Tore; Tveit, Kåre Steinar; Thu, Frode; Bull, Nils; Edward, Deepak P.; Hennekam, Raoul C.; Høvding, Gunnar Jr; Haugen, Olav H.; Houge, Gunnar Douzgos; Rødahl, Eyvind; Bruland, Ove (Journal article; Peer reviewed, 2021)
    Ocular pterygium-digital keloid dysplasia (OPDKD) presents in childhood with ingrowth of vascularized connective tissue on the cornea leading to severely reduced vision. Later the patients develop keloids on digits but are ...
  • Sex disparity in acute myeloid leukaemia with FLT3 internal tandem duplication mutations: implications for prognosis 

    Hellesøy, Monica; Engen, Caroline Benedicte Nitter; Grob, Tim; Löwenberg, Bob; Valk, Peter J. M.; Gjertsen, Bjørn T. (Journal article; Peer reviewed, 2021)
    Incidence, molecular presentation and outcome of acute myeloid leukaemia (AML) are influenced by sex, but little attention has been directed at untangling sex-related molecular and phenotypic differences between female and ...
  • Vitamin B status and association with antiseizure medication in pregnant women with epilepsy 

    Husebye, Elisabeth Synnøve Nilsen; Riedel, Bettina Maria Ingeborg; Monsen, Anne-Lise Bjørke; Spigset, Olav; Daltveit, Anne Kjersti Nesje; Gilhus, Nils Erik; Bjørk, Marte-Helene (Journal article; Peer reviewed, 2021)
    Objective Antiseizure medication (ASM) use interacts with vitamin B status in nonpregnant epilepsy populations. We aimed to examine the association between ASM and vitamin B status in pregnant women with epilepsy. Methods ...
  • Gender Differences in Kidney Stone Disease (KSD): Findings from a Systematic Review 

    Gillams, Kathryn; Jones, Patrick; Juliebø, Siri Øvereng; Somani, Bhaskar K. (Journal article; Peer reviewed, 2021)
    Purpose of review: The prevalence of kidney stones is rising and historically carries a preponderance for males. However, recent evidence has questioned whether this gender gap is closing. The aim of this systematic review ...
  • Early manifestations of genetic risk for neurodevelopmental disorders 

    Askeland, Ragna Bugge; Hannigan, Laurie J.; Ask, Helga; Ayorech, Ziada; Tesli, Martin Steen; Corfield, Elizabeth; Magnus, Per Minor; Njølstad, Pål Rasmus; Andreassen, Ole A.; Smith, George Davey; Reichborn-Kjennerud, Ted; Havdahl, Alexandra (Journal article; Peer reviewed, 2021)
    Background: Attention deficit/hyperactivity disorder (ADHD), autism spectrum disorder (autism) and schizophrenia are highly heritable neurodevelopmental disorders, affecting the lives of many individuals. It is important ...
  • A strategy towards the generation of testable adverse outcome pathways for nanomaterials 

    Murugadoss, Sivakumar; Vrcek, Ivana Vinkovic; Pem, Barbara; Jagiello, Karolina; Judzinska, Beata; Sosnowska, Anita; Martens, Marvin; Willighagen, Egon L.; Puzyn, Tomasz; Dusinska, Maria; Cimpan, Mihaela-Roxana; Fessard, Valérie; Hoet, Peter H. (Journal article; Peer reviewed, 2021)
    Manufactured nanomaterials (NMs) are increasingly used in a wide range of industrial applications leading to a constant increase in the market size of nano-enabled products. The increased production and use of NMs are ...
  • The natural history of 21-hydroxylase autoantibodies in autoimmune Addison’s disease 

    Wolff, Anette Susanne Bøe; Breivik, Lars Ertesvåg; Hufthammer, Karl Ove; Grytaas, Marianne; Bratland, Eirik; Husebye, Eystein Sverre; Oftedal, Bergithe Eikeland (Journal article; Peer reviewed, 2021)
    Background: The most common cause of primary adrenal failure (Addison’s disease) in the Western world is autoimmunity characterized by autoantibodies against the steroidogenic enzyme 21-hydroxylase (CYP21A2, 21OH). Detection ...
  • Targeted Next-Generation Sequencing of Cancer-Related Genes in a Norwegian Patient Cohort With Head and Neck Squamous Cell Carcinoma Reveals Novel Actionable Mutations and Correlations With Pathological Parameters 

    Dongre, Harsh N.; Haave, Hilde; Fromreide, Siren; Erland, Fredrik Atteraas; Moe, Svein Erik Emblem; Dhayalan, Sophia Manueldas; Riis, Rasmus Kopperud; Sapkota, Dipak; Costea, Daniela Elena; Aarstad, Hans Jørgen; Vintermyr, Olav Karsten (Journal article; Peer reviewed, 2021)
    Background: Targeted next-generation sequencing (NGS) is increasingly applied in clinical oncology to advance personalized treatment. Despite success in many other tumour types, use of targeted NGS panels for assisting ...
  • Analysis of salivary mycobiome in a cohort of oral squamous cell carcinoma patients from Sudan identifies higher salivary carriage of malassezia as an independent and favorable predictor of overall survival 

    Mohamed, Nazar; Litlekalsøy, Jorunn; Ahmed, Israa Abdul Rhman; Martinsen, Einar Marius Hjellestad; Furriol, Jessica; Javier-Lopez, Ruben; Elsheikh, Mariam; Mohamed, Nuha Mohamed Gaafar; Morgado, Luis; Mundra, Sunil; Johannessen, Anne Christine; Osman, Tarig Al-Hadi; Nginamau, Elisabeth Sivy; Suleiman, Ahmed; Costea, Daniela Elena (Journal article; Peer reviewed, 2021-10-12)
    Background: Microbial dysbiosis and microbiome-induced inflammation have emerged as important factors in oral squamous cell carcinoma (OSCC) tumorigenesis during the last two decades. However, the “rare biosphere” of the ...
  • Profiling and functional analysis of microRNA deregulation in cancer-associated fibroblasts in oral squamous cell carcinoma depicts an anti-invasive role of microRNA-204 via regulation of their motility 

    Rajthala, Saroj; Min, Anjie; Parajuli, Himalaya; Debnath, Kala Chand; Ljøkjel, Borghild; Hoven, Kristin Marie; Kvalheim, Arild; Lybak, Stein; Neppelberg, Evelyn; Vintermyr, Olav Karsten; Johannessen, Anne Christine; Sapkota, Dipak; Costea, Daniela Elena (Journal article; Peer reviewed, 2021-11-04)
    Background: Knowledge on the role of miR changes in tumor stroma for cancer progression is limited. This study aimed to investigate the role of miR dysregulation in cancer-associated fibroblasts (CAFs) in oral squamous ...
  • One chance to get it right: Improving clinical handovers for better symptom control at the end of life 

    Goldraij, Gabriel; Tripodoro, Vilma Adriana; Aloisio, Melisa; Castro, Sandra Analiá; Gerlach, Christina; Mayland, Catriona Rachel; Haugen, Dagny Renata Faksvåg (Journal article; Peer reviewed, 2021)
    Poor communication contributes to morbidity and mortality, not only in general medical care but also at the end oflife. This leads to issues relating to symptom control and quality of care. As part of an international ...
  • CRMP5 Antibodies—Diagnostic Challenges 

    Totland, Cecilie; Haugen, Mette; Vedeler, Christian Alexander (Journal article; Peer reviewed, 2021-09-22)
    CRMP5-associated paraneoplastic neurological syndromes (PNS) are rare, and only few studies describe larger cohorts of patients with CRMP5 antibodies. We have included 24 patients with CRMP5 antibodies and compared clinical ...
  • Genetic association study of childhood aggression across raters, instruments, and age 

    Ip, Hill F.; van der Laan, Camiel M.; Krapohl, Eva M. L.; Brikell, Isabell; Sánchez-Mora, Cristina; Nolte, Ilja M.; Pourcain, Beate St; Bolhuis, Koen; Palviainen, Teemu; Zafarmand, Hadi; Colodro-Conde, Lucía; Gordon, Scott; Zayats, Tetyana; Aliev, Fazil; Jiang, Chang; Wang, Carol A.; Saunders, Gretchen; Karhunen, Ville; Hammerschlag, Anke R.; Adkins, Daniel E.; Border, Richard; Peterson, Roseann E.; Prinz, Joseph A.; Thiering, Elisabeth; Seppälä, Iikka; Vilor-Tejedor, Natàlia; Ahluwalia, Tarunveer S.; Day, Felix R.; Hottenga, Jouke-Jan; Allegrini, Andrea G.; Rimfeld, Kaili; Chen, Qi; Yi, Lu; Martin, Joanna; Soler Artigas, Marìa; Rovira, Paula; Bosch, Rosa; Español, Gemma; Ramos-Quiroga, Josep Antonio; Neumann, Alexander; Haavik, Jan; Harris, Jennifer Ruth; Helgeland, Øyvind; Johansson, Stefan; Knudsen, Gun Peggy Strømstad; Njølstad, Pål Rasmus; Havdahl, Alexandra; Magnus, Per Minor; Reichborn-Kjennerud, Ted; Boomsma, Dorret I. (Journal article; Peer reviewed, 2021)
    Childhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from ...
  • Birth Weight Is Associated With Kidney Size in Middle-Aged Women 

    Lillås, Bjørn Steinar; Qvale, Tor Hatlestad; Richter, Blazej Konrad; Vikse, Bjørn Egil (Journal article; Peer reviewed, 2021)
    Introduction Low birth weight (LBW) is associated with increased risk of kidney disease due to lower nephron endowment leading to hyperfiltration and subsequent nephron loss. Kidney size is commonly used as a proxy for ...
  • A human iPSC-astroglia neurodevelopmental model reveals divergent transcriptomic patterns in schizophrenia 

    Szabo, Attila; Akkouh, Ibrahim Ahmed; Vandenberghe, Matthieu; Osete, Jordi Requena; Hughes, Timothy; Heine, Vivi M.; Smeland, Olav Bjerkehagen; Glover, Joel Clinton; Andreassen, Ole; Djurovic, Srdjan (Journal article; Peer reviewed, 2021)
    While neurodevelopmental abnormalities have been associated with schizophrenia (SCZ), the role of astroglia in disease pathophysiology remains poorly understood. In the present study, we used a human induced pluripotent ...

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