• Neuronal Dysfunction Is Linked to the Famine-Associated Risk of Proliferative Retinopathy in Patients With Type 2 Diabetes 

  Fedotkina, Olena; Jain, Ruchi; Prasad, Rashmi B.; Luk, Andrea; García-Ramírez, Marta; Özgümüs, Türküler; Cherviakova, Liubov; Khalimon, Nadiya; Svietleisha, Tetiana; Buldenko, Tetiana; Kravchenko, Victor; Jain, Deepak; Vaag, Allan; Chan, Juliana; Khalangot, Mykola D.; Hernández, Cristina; Nilsson, Peter M.; Simo, Rafael; Artner, Isabella; Lyssenko, Valeriya (Journal article; Peer reviewed, 2022-05-05)

  Persons with type 2 diabetes born in the regions of famine exposures have disproportionally elevated risk of vision-threatening proliferative diabetic retinopathy (PDR) in adulthood. However, the underlying mechanisms are ...

• Clonal evolution after treatment pressure in multiple myeloma: heterogenous genomic aberrations and transcriptomic convergence 

  Misund, Kristine; Hofste op Bruinink, Davine; Coward, Eivind; Hoogenboezem, Remco M.; Rustad, Even Holth; Sanders, Mathijs A.; Rye, Morten Beck; Sponaas, Anne-Marit; van der Holt, Bronno; Zweegman, Sonja; Hovig, Eivind; Meza, Leonardo Zepeda; Sundan, Anders; Myklebost, Ola; Sonneveld, Pieter; Waage, Anders (Journal article; Peer reviewed, 2022)

  We investigated genomic and transcriptomic changes in paired tumor samples of 29 in-house multiple myeloma (MM) patients and 28 patients from the MMRF CoMMpass study before and after treatment. A change in clonal composition ...

• Auxilin is a novel susceptibility gene for congenital heart block which directly impacts fetal heart function 

  Meisgen, Sabrina; Hedlund, Malin; Ambrosi, Aurelie; Folkersen, Lasse; Ottosson, Vijole; Forsberg, David; Thorlacius, Gudny Ella; Biavati, Luca; Strandberg, Linn; Mofors, Johannes; Ramskold, Daniel; Ruhrmann, Sabrina; Meneghel, Lauro; Nyberg, William; Espinosa, Alexander; Hamilton, Robert Murray; Franco-Cereceda, Anders; Hamsten, Anders; Olsson, Tomas; Greene, Lois; Eriksson, Per; Gemzell-Danielsson, Kristina; Salomonsson, Stina; Kuchroo, Vijay K; Herlenius, Eric; Kockum, Ingrid; Sonesson, Sven-Erik; Herlenius, Marie Elisabeth Wahren (Journal article; Peer reviewed, 2022)

  Objective: Neonatal lupus erythematosus (NLE) may develop after transplacental transfer of maternal autoantibodies with cardiac manifestations (congenital heart block, CHB) including atrioventricular block, atrial and ...

• The value of histological examination in the diagnosis of tuberculous lymphadenitis in the era of rapid molecular diagnosis 

  Tahseen, Sabira; Ambreen, Atiqa; Ishtiaq, Sheeba; Khanzada, Faisal M.; Safdar, Nauman; Sviland, Lisbet; Mustafa, Tehmina (Journal article; Peer reviewed, 2022)

  Extrapulmonary tuberculosis often poses a diagnostic challenge. This study aimed to assess the value of histological examination in diagnosing tuberculous lymphadenitis (LNTB) when performed simultaneously with rapid ...

• Islet cell replacement and transplantation immunology in a mouse strain with inducible diabetes 

  Bhagchandani, Preksha; Chang, Charles A.; Zhao, Weichen; Ghila, Luiza Mihaela; Herrera, Pedro L.; Chera, Simona; Kim, Seung K. (Journal article; Peer reviewed, 2022)

  Improved models of experimental diabetes are needed to develop cell therapies for diabetes. Here, we introduce the B6 RIP-DTR mouse, a model of experimental diabetes in fully immunocompetent animals. These inbred mice ...

• Prematur ovarialinsuffisiens 

  Vogt, Elinor Margrethe Chelsom; Russell, Hannah Ni Bhriain; Øksnes, Marianne; Lund, Agnethe (Journal article; Peer reviewed, 2022)

  Prematur ovarialinsuffisiens defineres som tap av ovariefunksjon før 40 års alder og er en kompleks tilstand med heterogen etiologi. Tidlig diagnose og igangsetting av hormonerstattende behandling er viktig for å lindre ...

• Radiation induced brain necrosis after proton therapy for head and neck cancer 

  Engeseth, Grete May (Doctoral thesis, 2022-12-09)

  Protonterapi gir reduksjon i normalvevsdoser sammenlignet med strålebehandling med fotoner, og det er antatt at dette vil resultere i en lavere forekomst av stråleinduserte seinskader. For å kompensere for en økt biologisk ...

• Physician participation in quality improvement work- interest and opportunity: a cross-sectional survey 

  Deilkås, Ellen C Tveter; Rosta, Judith; Baathe, Fredrik; Søfteland, Eirik; Lexberg, Åse; Røise, Olav; Isaksson Rø, Karin Elisabet (Journal article; Peer reviewed, 2022-10-25)

  Background: Lack of physician involvement in quality improvement threatens the success and sustainability of quality improvement measures. It is therefore important to assess physicians´ interests and opportunities to be ...

• Geographical variation in orthopedic procedures in Norway: Cross-sectional population-based study 

  Holsen, Maria; Hovind, Veronica; Bedane, Haji Kedir; Osvoll, Knut Ivar; Gjertsen, Jan-Erik; Furnes, Ove Nord; Walsh, Mary E.; Ingebrigtsen, Tor (Journal article; Peer reviewed, 2022)

  Background: Standardized surgery rates for common orthopedic procedures vary across geographical areas in Norway. We explored whether area-level factors related to demand and supply in publicly funded healthcare are ...

• MRI adipose tissue segmentation and quantification in R (RAdipoSeg) 

  Haugen, Christine; Lysne, Vegard; Haldorsen, Ingfrid S.; Tjora, Erling; Gudbrandsen, Oddrun Anita; Sagen, Jørn Vegard; Dankel, Simon N; Mellgren, Gunnar (Journal article; Peer reviewed, 2022-10-08)

  Background: Excess adipose tissue is associated with increased cardiovascular and metabolic risk, but the volume of visceral and subcutaneous adipose tissue poses different metabolic risks. MRI with fat suppression can be ...

• Assessment of Small Bowel Motility and SMA Blood Flow Studied with Transabdominal Ultrasound 

  Nylund, Kim; Gjengsto, Andreas Jessen; Volkmann, Hilde Løland Von; Gilja, Odd Helge (Journal article; Peer reviewed, 2022)

  Purpose: Gastrointestinal ultrasound (GIUS) is a noninvasive imaging technique that may be used to study physiological changes in the small bowel. The aim of the study was to investigate the feasibility of measuring blood ...

• Hypersementose og endodontiske implikasjoner 

  Zakariyya, Gunel; Fristad, Inge (Journal article; Peer reviewed, 2022)

  Hypersementose er forbundet med lokale og systemiske faktorer, men etiologien er ikke godt kartlagt. Vanskeligheter med å bedømme røntgenologisk tykkelse på sementlaget ved hypersementose, vil direkte kunne påvirke beslutning ...

• Impact of rapid molecular testing on diagnosis, treatment and management of community-acquired pneumonia in Norway: a pragmatic randomised controlled trial (CAPNOR) 

  Serigstad, Sondre; Ritz, Christian; Faurholt-Jepsen, Daniel; Markussen, Dagfinn Lunde; Ebbesen, Marit Helen; Kommedal, Øyvind; Bjørneklett, Rune Oskar; Heggelund, Lars; Clark, Tristan W.; van Werkhoven, Cornelis H.; Knoop, Siri Tandberg; Ulvestad, Elling; Grewal, Harleen (Journal article; Peer reviewed, 2022)

  Background: Community-acquired pneumonia (CAP) causes a large burden of disease. Due to difficulties in obtaining representative respiratory samples and insensitive standard microbiological methods, the microbiological ...

• Dietary practices and nutritional status of young children in the former ensete monoculture dominated Sidama region, southern Ethiopia: A community based cross-sectional study 

  Kebede, Tsigereda Behailu; Mengesha, Selamawit; Lindtjorn, Bernt; Engebretsen, Ingunn Marie Stadskleiv (Journal article; Peer reviewed, 2022-09-14)

  Background: Child undernutrition is a challenge in Ethiopia, where morbidity and mortality among children are attributed to it. This study aimed to describe the dietary practices, household food insecurity, and nutritional ...

• Assessing the Anti-Inflammatory Effects of an Orally Dosed Enzymatically Liberated Fish Oil in a House Dust Model of Allergic Asthma 

  Currie, Crawford; Framroze, Bomi; Singh, Dave; Lea, Simon; Bjerknes, Christian; Hermansen, Erland (Journal article; Peer reviewed, 2022-10-14)

  Eosinophils are a major driver of inflammation in a number of human diseases, including asthma. Biologic therapies targeting IL-5 have enabled better control of severe eosinophilic asthma, but no such advances have been ...

• Health-related quality of life in patients with advanced melanoma treated with ipilimumab: prognostic implications and changes during treatment 

  Aamdal, Elin; Skovlund, Eva; Jacobsen, Kari Dolven; Straume, Oddbjørn; Kersten, Christian; Herlofsen, Oluf; Karlsen, Jarle; Hussain, Israr; Amundsen, Anita; Dalhaug, Astrid; Nyakas, Marta Sølvi; Hagene, Kirsten Thorin; Holmsen, Kjersti; Aamdal, Steinar; Kaasa, Stein; Guren, Tormod Kyrre; Kyte, Jon A (Journal article; Peer reviewed, 2022)

  Background: We have previously reported that the safety and efficacy of ipilimumab in real-world patients with metastatic melanoma were comparable to clinical trials. Few studies have explored health-related quality of ...

• Plasma unmetabolized folic acid in pregnancy and risk of autistic traits and language impairment in antiseizure medication-exposed children of women with epilepsy 

  Husebye, Elisabeth Synnøve Nilsen; Wendel, Annabel Willemijn Karine; Gilhus, Nils Erik; Riedel, Bettina Maria Ingeborg; Bjørk, Marte-Helene (Journal article; Peer reviewed, 2022)

  Background: Fetal exposure to unmetabolized folic acid (UMFA) during pregnancy may be associated with adverse neurodevelopment. Antiseizure medication (ASM) may interact with folate metabolism. Women with epilepsy using ...

• Dietary selenomethionine reduce mercury tissue levels and modulate methylmercury induced proteomic and transcriptomic alterations in hippocampi of adolescent BALB/c mice 

  Mellingen, Ragnhild Marie; Myrmel, Lene Secher; Rasinger, Josef; Lie, Kai Kristoffer; Bernhard, Annette; Madsen, Lise; Nøstbakken, Ole Jakob (Journal article; Peer reviewed, 2022-10-13)

  Methylmercury (MeHg) is a well-known environmental contaminant, particularly harmful to the developing brain. The main human dietary exposure to MeHg occurs through seafood consumption. However, seafood also contains several ...

• Gut microbiota and fecal microbiota transplantation in patients with food allergies: A systematic review 

  Jensen, Caroline; Antonsen, Marie Fagervik; Lied, Gülen Arslan (Journal article; Peer reviewed, 2022-09-26)

  The prevalence of food allergies (FAs) has increased considerably in recent decades, with the only available treatment being the avoidance of the specific food items causing the allergy. FAs may have a major impact on ...

• The survival gap between young and older patients after surgical resection for colorectal cancer remains largely based on early mortality: A EURECCA comparison of four European countries. 

  Bahadoer, Renu R.; Bastiaannet, Esther; Peeters, Koen C.M.J.; van Eycken, Elizabeth; Verbeeck, Julie; Guren, Marianne; Kørner, Hartwig; Martling, Anna; Johansson, Robert; van de Velde, Cornelis J.H.; Dekker, Jan Willem T. (Journal article; Peer reviewed, 2022)

  Background: A decade ago, it was demonstrated that the difference in survival between older patients and younger patients with colorectal cancer (CRC) was mainly due to mortality in the first postoperative year. Over the ...

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