• Use of sildenafil and other phosphodiesterase type 5 inhibitors among pregnant women in Scandinavia 

  Cesta, Carolyn E.; Segovia Chacón, Silvia; Engeland, Anders; Broe, Anne; Damkier, Per; Furu, Kari; Kieler, Helle; Karlsson, Pär (Journal article; Peer reviewed, 2021)

  Introduction For phosphodiesterase type 5 (PDE5) inhibitors, such as sildenafil, the only approved indication in women is for pulmonary arterial hypertension. These drugs are increasingly being proposed and tested for ...

• Targeted Next-Generation Sequencing of Cancer-Related Genes in a Norwegian Patient Cohort With Head and Neck Squamous Cell Carcinoma Reveals Novel Actionable Mutations and Correlations With Pathological Parameters 

  Dongre, Harsh N.; Haave, Hilde; Fromreide, Siren; Erland, Fredrik Atteraas; Moe, Svein Erik Emblem; Dhayalan, Sophia Manueldas; Riis, Rasmus Kopperud; Sapkota, Dipak; Costea, Daniela Elena; Aarstad, Hans Jørgen; Vintermyr, Olav Karsten (Journal article; Peer reviewed, 2021)

  Background: Targeted next-generation sequencing (NGS) is increasingly applied in clinical oncology to advance personalized treatment. Despite success in many other tumour types, use of targeted NGS panels for assisting ...

• Analysis of salivary mycobiome in a cohort of oral squamous cell carcinoma patients from Sudan identifies higher salivary carriage of malassezia as an independent and favorable predictor of overall survival 

  Mohamed, Nazar; Litlekalsøy, Jorunn; Ahmed, Israa Abdul Rhman; Martinsen, Einar Marius Hjellestad; Furriol, Jessica; Javier-Lopez, Ruben; Elsheikh, Mariam; Mohamed, Nuha Mohamed Gaafar; Morgado, Luis; Mundra, Sunil; Johannessen, Anne Christine; Osman, Tarig Al-Hadi; Nginamau, Elisabeth Sivy; Suleiman, Ahmed; Costea, Daniela Elena (Journal article; Peer reviewed, 2021-10-12)

  Background: Microbial dysbiosis and microbiome-induced inflammation have emerged as important factors in oral squamous cell carcinoma (OSCC) tumorigenesis during the last two decades. However, the “rare biosphere” of the ...

• Profiling and functional analysis of microRNA deregulation in cancer-associated fibroblasts in oral squamous cell carcinoma depicts an anti-invasive role of microRNA-204 via regulation of their motility 

  Rajthala, Saroj; Min, Anjie; Parajuli, Himalaya; Debnath, Kala Chand; Ljøkjel, Borghild; Hoven, Kristin Marie; Kvalheim, Arild; Lybak, Stein; Neppelberg, Evelyn; Vintermyr, Olav Karsten; Johannessen, Anne Christine; Sapkota, Dipak; Costea, Daniela Elena (Journal article; Peer reviewed, 2021-11-04)

  Background: Knowledge on the role of miR changes in tumor stroma for cancer progression is limited. This study aimed to investigate the role of miR dysregulation in cancer-associated fibroblasts (CAFs) in oral squamous ...

• One chance to get it right: Improving clinical handovers for better symptom control at the end of life 

  Goldraij, Gabriel; Tripodoro, Vilma Adriana; Aloisio, Melisa; Castro, Sandra Analiá; Gerlach, Christina; Mayland, Catriona Rachel; Haugen, Dagny Renata Faksvåg (Journal article; Peer reviewed, 2021)

  Poor communication contributes to morbidity and mortality, not only in general medical care but also at the end oflife. This leads to issues relating to symptom control and quality of care. As part of an international ...

• CRMP5 Antibodies—Diagnostic Challenges 

  Totland, Cecilie; Haugen, Mette; Vedeler, Christian Alexander (Journal article; Peer reviewed, 2021-09-22)

  CRMP5-associated paraneoplastic neurological syndromes (PNS) are rare, and only few studies describe larger cohorts of patients with CRMP5 antibodies. We have included 24 patients with CRMP5 antibodies and compared clinical ...

• Genetic association study of childhood aggression across raters, instruments, and age 

  Ip, Hill F.; van der Laan, Camiel M.; Krapohl, Eva M. L.; Brikell, Isabell; Sánchez-Mora, Cristina; Nolte, Ilja M.; Pourcain, Beate St; Bolhuis, Koen; Palviainen, Teemu; Zafarmand, Hadi; Colodro-Conde, Lucía; Gordon, Scott; Zayats, Tetyana; Aliev, Fazil; Jiang, Chang; Wang, Carol A.; Saunders, Gretchen; Karhunen, Ville; Hammerschlag, Anke R.; Adkins, Daniel E.; Border, Richard; Peterson, Roseann E.; Prinz, Joseph A.; Thiering, Elisabeth; Seppälä, Iikka; Vilor-Tejedor, Natàlia; Ahluwalia, Tarunveer S.; Day, Felix R.; Hottenga, Jouke-Jan; Allegrini, Andrea G.; Rimfeld, Kaili; Chen, Qi; Yi, Lu; Martin, Joanna; Soler Artigas, Marìa; Rovira, Paula; Bosch, Rosa; Español, Gemma; Ramos-Quiroga, Josep Antonio; Neumann, Alexander; Haavik, Jan; Harris, Jennifer Ruth; Helgeland, Øyvind; Johansson, Stefan; Knudsen, Gun Peggy Strømstad; Njølstad, Pål Rasmus; Havdahl, Alexandra; Magnus, Per Minor; Reichborn-Kjennerud, Ted; Boomsma, Dorret I. (Journal article; Peer reviewed, 2021)

  Childhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from ...

• Birth Weight Is Associated With Kidney Size in Middle-Aged Women 

  Lillås, Bjørn Steinar; Qvale, Tor Hatlestad; Richter, Blazej Konrad; Vikse, Bjørn Egil (Journal article; Peer reviewed, 2021)

  Introduction Low birth weight (LBW) is associated with increased risk of kidney disease due to lower nephron endowment leading to hyperfiltration and subsequent nephron loss. Kidney size is commonly used as a proxy for ...

• A human iPSC-astroglia neurodevelopmental model reveals divergent transcriptomic patterns in schizophrenia 

  Szabo, Attila; Akkouh, Ibrahim Ahmed; Vandenberghe, Matthieu; Osete, Jordi Requena; Hughes, Timothy; Heine, Vivi M.; Smeland, Olav Bjerkehagen; Glover, Joel Clinton; Andreassen, Ole; Djurovic, Srdjan (Journal article; Peer reviewed, 2021)

  While neurodevelopmental abnormalities have been associated with schizophrenia (SCZ), the role of astroglia in disease pathophysiology remains poorly understood. In the present study, we used a human induced pluripotent ...

• Gender Differences in Kidney Stone Disease (KSD): Findings from a Systematic Review 

  Gillams, Kathryn; Jones, Patrick; Juliebø, Siri Øvereng; Somani, Bhaskar K. (Journal article; Peer reviewed, 2021)

  Purpose of review: The prevalence of kidney stones is rising and historically carries a preponderance for males. However, recent evidence has questioned whether this gender gap is closing. The aim of this systematic review ...

• Challenges and possible solutions in cross-disciplinary and cross-sectorial research teams within the domain of e-mental health 

  Nordgreen, Tine; Rabbi, Fazle; Tørresen, Jim; Skar, Yngvar Sigmund; Guribye, Frode; Inal, Yavuz; Flobak, Eivind; Wake, Jo Dugstad; Mukhiya, Suresh Kumar; Aminifar, Amin; Myklebost, Sunniva Brurok; Lundervold, Astri J.; Kenter, Robin Maria Francisca; Hammar, Åsa Karin; Kahlon, Smiti; Nordby, Emilie; Sekse, Ragnhild Johanne Tveit; Griffin, Kristine Fonnes; Jakobsen, Petter; Pham, Hoang Minh; Côté-Allard, Ulysse Teller Masao; Noori, Farzan Majeed; Lamo, Yngve (Journal article; Peer reviewed, 2021)

  Purpose: Mental illness presents a huge individual, societal and economic challenges, currently accounting for 20% of the worldwide burden of disease. There is a gap between the need for and access to services. Digital ...

• Identification of host biomarkers from dried blood spots for monitoring treatment response in extrapulmonary tuberculosis 

  Khalid, Shizza (Master thesis, 2021-10-12)

• Short and long-term effects of single and multiple sessions of electroconvulsive therapy on brain gray matter volumes 

  Brancati, Giulio Emilio; Brekke, Njål; Bartsch, Hauke; Sørhaug, Ole Johan Evjenth; Ousdal, Olga Therese; Hammar, Åsa Karin; Schuster, Peter Moritz; Ødegaard, Ketil Joachim; Kessler, Ute; Oltedal, Leif (Journal article; Peer reviewed, 2021)

  Background: Electroconvulsive therapy (ECT) has been shown to induce broadly distributed cortical and subcortical volume increases, more prominently in the amygdala and the hippocampus. Structural changes after one ECT ...

• Distinct Mitochondrial Remodeling During Mesoderm Differentiation in a Human-Based Stem Cell Model 

  Mostafavi, Sepideh; Balafkan, Novin; Pettersen, Ina Katrine Nitschke; Nido, Gonzalo Sanchez; Siller, Richard; Tzoulis, Charalampos; Sullivan, Gareth John; Bindoff, Laurence Albert (Journal article; Peer reviewed, 2021-10-14)

  Given the considerable interest in using stem cells for modeling and treating disease, it is essential to understand what regulates self-renewal and differentiation. Remodeling of mitochondria and metabolism, with the shift ...

• Wavelet Screening: a novel approach to analyzing GWAS data 

  Denault, William Robert Paul; Gjessing, Håkon K.; Juodakis, Julius; Jacobsson, Bo; Jugessur, Astanand (Journal article; Peer reviewed, 2021)

  Background Traditional methods for single-variant genome-wide association study (GWAS) incur a substantial multiple-testing burden because of the need to test for associations with a vast number of single-nucleotide ...

• Intestinal Ultrasound to Assess Disease Activity in Ulcerative Colitis: Development of a novel UC-Ultrasound Index 

  Bots, Steven; Nylund, Kim; Löwenberg, Mark; Gecse, Krisztina; D'Haens, Geert (Journal article; Peer reviewed, 2021)

  Introduction: Intestinal ultrasound [IUS] is useful to assess inflammation in ulcerative colitis [UC] patients. We aimed to develop an ultrasonographic activity index using endoscopy as the reference standard. Methods: ...

• Establishing quality indicators for prehospital advanced airway management: a modified nominal group technique consensus process 

  Kottmann, Alexandre; Krüger, Andreas J.; Sunde, Geir A.; Røislien, Jo; Heltne, John-Kenneth; Carron, Pierre Nicolas; Lockey, David; Sollid, Stephen J. M. (Journal article; Peer reviewed, 2021)

  Background: Prehospital advanced airway management is a complex intervention composed of numerous steps, interactions, and variables that can be delivered to a high standard in the prehospital setting. Standard research ...

• The Course of Carotid Plaque Vulnerability Assessed by Advanced Neurosonology 

  Aarli, Sander Johan; Thomassen, Lars; Waje-Andreassen, Ulrike; Logallo, Nicola; Kvistad, Christopher Elnan; Næss, Halvor; Fromm, Annette (Journal article; Peer reviewed, 2021-08-20)

  Background: Carotid artery atherosclerosis is a major risk factor for ischemic stroke. This risk is related to plaque vulnerability and is characterized by plaque morphology, intraplaque neovascularization, and cerebral ...

• Simultaneous Resection of Primary Colorectal Cancer and Synchronous Liver Metastases: Contemporary Practice, Evidence and Knowledge Gaps 

  Kleive, Dyre; Aas, Eline; Angelsen, Jon-Helge; Bringeland, Erling Audun; Nesbakken, Arild; Nymo, Linn Såve; Schultz, Johannes Kurt; Søreide, Kjetil; Yaqub, Sheraz (Journal article; Peer reviewed, 2021)

  The timing of surgical resection of synchronous liver metastases from colorectal cancer has been debated for decades. Several strategies have been proposed, but high-level evidence remains scarce. Simultaneous resection ...

• Interleukin-2 receptor in the pathogenesis of diabetic complications and Sjögren's syndrome 

  Keindl, Magdalena (Doctoral thesis, 2021-12-14)

  The cytokine interleukin-2 (IL-2) acts as a double-edged sword by promoting both immunity and immune tolerance. Regulatory T cells (Tregs) are responsible for maintaining self-tolerance and constitutively express the high ...

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