Recent Submissions

  • MicroRNA-138 abates fibroblast motility with effect on invasion of adjacent cancer cells 

    Rajthala, Saroj; Parajuli, Himalaya; Dongre, Harsh Nitin; Ljøkjel, Borghild; Hoven, Kristin Marie; Kvalheim, Arild; Lybak, Stein; Neppelberg, Evelyn; Sapkota, Dipak; Johannessen, Anne Christine; Costea, Daniela Elena (Journal article; Peer reviewed, 2022-03-17)
    Background: Recent studies have shown aberrant expression of micro-RNAs in cancer-associated fibroblasts (CAFs). This study aimed to investigate miR-138 dysregulation in CAFs in oral squamous cell carcinoma (OSCC) and its ...
  • Understanding proteostasis dysregulation in phenylketonuria – a paradigm disease for inborn error of metabolism 

    Prestegård, Karina Skjervheim (Doctoral thesis, 2022-09-06)
    Fenylketonuria (PKU) er en medfødt stoffskiftesykdom forårsaket av mutasjoner i genet for fenylalanin hydroksylase (PAH), og fører til ustabile og ofte feilfoldete enzymer med nedsatt evne til å metabolisere aminosyren ...
  • LRFN5 locus structure is associated with autism and influenced by the sex of the individual and locus conversions 

    Lybæk, Helle; Robson, Michael; de Leeuw, Nicole; Hehir-Kwa, Jayne Y.; Jeffries, Aaron; Haukanes, Bjørn Ivar; Berland, Siren; de Bruijn, Diederik; Mundlos, Stefan; Spielmann, Malte; Houge, Gunnar Douzgos (Journal article; Peer reviewed, 2022)
    LRFN5 is a regulator of synaptic development and the only gene in a 5.4 Mb mammalian-specific conserved topologically associating domain (TAD); the LRFN5 locus. An association between locus structural changes and developmental ...
  • Kaplan-Meier and Cox Regression Are Preferable for the Analysis of Time to Revision of Joint Arthroplasty: Thirty-One Years of Follow-up for Cemented and Uncemented THAs Inserted from 1987 to 2000 in the Norwegian Arthroplasty Register 

    Lie, Stein Atle; Fenstad, Anne Marie; Lygre, Stein Håkon Låstad; Kroken, Gard; Dybvik, Eva Hansen; Gjertsen, Jan-Erik; Hallan, Geir; Dale, Håvard; Furnes, Ove Nord (Journal article; Peer reviewed, 2022)
    Background: Previous studies have suggested that the probability function of 1 minus the Kaplan-Meier survivorship overestimates revision rates of implants and that patient death should be included in estimates as a competing ...
  • Buegangsdehiscens 

    Goplen, Frederik Kragerud; Hess-Erga, Jeanette; Opheim, Leif Runar; Silvola, Juha Tapio; Stene, Brit Kari; Törpel, Jörg; Uppheim, Alexander; Bunne, Bodil Iris Marie (Journal article; Peer reviewed, 2022)
    Buegangsdehiscens er en tilstand med plagsomme øresymptomer og svimmelhet forårsaket av en defekt i benet mellom det indre øret og midtre skallegrop. Sykdommen er ufarlig, og for mange pasienter er det tilstrekkelig med ...
  • Early Evolutionary Selection of NAD Biosynthesis Pathway in Bacteria 

    Sharma, Suraj; Hsieh, Yin-Chen; Dietze, Jørn; Bockwoldt, Mathias; Strømland, Øyvind; Ziegler, Mathias; Heiland, Ines (Journal article; Peer reviewed, 2022)
    Bacteria use two alternative pathways to synthesize nicotinamide adenine dinucleotide (NAD) from nicotinamide (Nam). A short, two-step route proceeds through nicotinamide mononucleotide (NMN) formation, whereas the other ...
  • Correlation between gene expression and MRI STIR signals in patients with chronic low back pain and Modic changes indicates immune involvement 

    Vigeland, Maria Dehli; Flåm, Siri Tennebø; Vigeland, Magnus Dehli; Espeland, Ansgar; Kristoffersen, Per Martin; Vetti, Nils; Wigemyr, Monica; Bråten, Lars Christian Haugli; Gjefsen, Elisabeth; Schistad, Ellina Iordanova; Haugen, Anne Julsrud; Johanessen, Anne Froholdt; Skouen, Jan Sture; Zwart, John Anker Henrik; Storheim, Kjersti; Pedersen, Linda Margareth; Lie, Benedicte Alexandra (Journal article; Peer reviewed, 2022-01-07)
    Disability and distress caused by chronic low back pain (LBP) lacking clear pathoanatomical explanations cause huge problems both for patients and society. A subgroup of patients has Modic changes (MC), identifiable by MRI ...
  • Systematic reporting of medical kidney biopsies 

    Leh, Sabine; Dendooven, Amélie (Journal article; Peer reviewed, 2022)
    The medical kidney biopsy has an important added value in patient care in nephrology. In order to facilitate communication between the pathologist and the nephrologist and optimize patient care, both the content and form ...
  • Enhancement of cranial nerves in Lyme neuroborreliosis: incidence and correlation with clinical symptoms and prognosis 

    Lindland, Elisabeth Margrete Stokke; Solheim, Anne Marit; Dareez, Muhammad Nazeer; Eikeland, Randi; Ljøstad, Unn; Mygland, Åse Daasvand; Reiso, Harald; Lorentzen, Åslaug Rudjord; Harbo, Hanne; Beyer, Mona Kristiansen (Journal article; Peer reviewed, 2022)
    Purpose Symptoms of cranial neuritis are a common presentation of Lyme neuroborreliosis (LNB). Imaging studies are scarce and report contradictory low prevalence of enhancement compared to clinical studies of cranial ...
  • Association of adverse childhood experiences with the development of multiple sclerosis 

    Eid, Karine; Torkildsen, Øivind; Aarseth, Jan Harald; Aalstad, Mari; Bhan, Alok; Celius, Elisabeth Gulowsen; Cortese, Marianna; Daltveit, Anne Kjersti Nesje; Holmøy, Trygve; Myhr, Kjell-Morten; Riise, Trond; Schuler, Stephan; Torkildsen, Cecilie Fredvik; Wergeland, Stig; Gilhus, Nils Erik; Bjørk, Marte-Helene (Journal article; Peer reviewed, 2022)
    Objective To study whether exposure to childhood emotional, sexual or physical abuse is associated with subsequent multiple sclerosis (MS) development. Methods A nationwide, prospective cohort study based on participants ...
  • Changes in colonic enteroendocrine cells of patients with irritable bowel syndrome following fecal microbiota transplantation 

    Mazzawi, Tarek; Hausken, Trygve; El-Salhy, Magdy (Journal article; Peer reviewed, 2022)
    Objectives The aim was to investigate the effect of fecal microbiota transplantation (FMT) on colonic enteroendocrine cells densities in patients with irritable bowel syndrome (IBS). Materials and methods This study ...
  • Factors affecting fracture of zirconia dental crowns : Laboratory studies on retrievals and crown-shaped specimens 

    Skjold, Anneli (Doctoral thesis, 2022-09-02)
    Objektiv: De siste 20 årene har bruken av zirkonia som dentalt materiale har økt betydelig. Laboratorietester som undersøker materialstyrke, indikerer at de tilgjengelige zirkonia-materialene har tilstrekkelige mekaniske ...
  • Trends in Mortality Due to Myocardial Infarction, Stroke, and Pulmonary Embolism in Patients Receiving Dialysis 

    Ocak, Gurbey; Boenink, Rianne; Noordzij, Marlies; Bos, Willem Jan W.; Vikse, Bjørn Egil; Cases, Aleix; Kerschbaum, Julia; Helve, Jaakko; Nordio, Maurizio; Arici, Mustafa; Mercadal, Lucile; Wanner, Christoph; Palsson, Runolfur; Hommel, Kristine; De Meester, Johan; Kostopoulou, Myrto; Santamaria, Rafael; Rodrigo, Emilio; Rydell, Helena; Bell, Samira; Massy, Ziad A.; Jager, Kitty J.; Kramer, Anneke (Journal article; Peer reviewed, 2022)
    Importance: During the past decades, improvements in the prevention and management of myocardial infarction, stroke, and pulmonary embolism have led to a decline in cardiovascular mortality in the general population. ...
  • Genetic epidemiology of amyotrophic lateral sclerosis in Norway - a 2-year population based study 

    Olsen, Cathrine Goberg; Busk, Øyvind Løvold; Aanjesen, Tori Navestad; Alstadhaug, Karl Bjørnar; Bjørnå, Ingrid Kristine; Braathen, Geir Julius; Breivik, Kristin Lif; Demic, Natasha; Flemmen, Heidi Øyen; Hallerstig, Erika; HogenEsch, Ineke; Holla, Øystein Lunde; Jøntvedt, Anne Berit; Kampman, Margitta T.; Kleveland, Grethe; Kvernmo, Helene Ballo; Ljøstad, Unn; Maniaol, Angelina; Morsund, Åse Hagen; Nakken, Ola; Novy, Camilla; Rekand, Tiina; Schlüter, Katrin Ruth; Schuler, Stephan; Tveten, Kristian; Tysnes, Ole-Bjørn; Holmøy, Trygve; Høyer, Helle (Journal article; Peer reviewed, 2022)
    Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects motor neurons. In Europe, disease-causing genetic variants have been identified in 40-70% of familial ALS patients and approximately ...
  • "Det er det som gjør at jeg har et rikt liv" - En studie om hjemmeboende eldre sine erfaringer med fysisk og sosial aktivitet før og under covid-19 

    Smedsland, Hege (Master thesis, 2022-06-15)
    Det blir flere eldre i befolkningen og det er forventet en økning i levealder. For at eldre skal kunne opprettholde optimal kroppsfunksjon og ivareta helsa, er fysisk aktivitet av stor betydning. Da covid-19 kom, ble eldre ...
  • Long-Term Outcome in a Phase II Study of Regional Hyperthermia Added to Preoperative Radiochemotherapy in Locally Advanced and Recurrent Rectal Adenocarcinomas 

    Schem, Baard-Christian; Pfeffer, Frank; Ott, Martin Anton; Wiig, Johan N.; Sletteskog, Nils; Frøystein, Torbjørn; Myklebust, Mette Pernille; Leh, Sabine; Dahl, Olav; Mella, Olav (Journal article; Peer reviewed, 2022-01-29)
    Hyperthermia was added to standard preoperative chemoradiation for rectal adenocarcinomas in a phase II study. Patients with T3-4 N0-2 M0 rectal cancer or local recurrences were included. Radiation dose was 54 Gy combined ...
  • Mitochondrial respiratory chain dysfunction—A hallmark pathology of idiopathic Parkinson’s disease? 

    Flønes, Irene Hana; Tzoulis, Charalampos (Journal article; Peer reviewed, 2022)
    Parkinson’s disease (PD) is the most common age-dependent neurodegenerative synucleinopathy. Loss of dopaminergic neurons of the substantia nigra pars compacta, together with region- and cell-specific aggregations of ...
  • Metric based virtual simulation training for endovascular thrombectomy improves interventional neuroradiologists’ simulator performance 

    Schneider, Magnus Sundgot; Sandve, Knut Olav Lende; Kurz, Kathinka Dæhli; Dalen, Ingvild; Ospel, Johanna; Goyal, Mayank; Kurz, Friedrich Martin Wilhelm; Fjetland, Lars (Journal article; Peer reviewed, 2022)
    Objective Metric based virtual reality simulation training may enhance the capability of interventional neuroradiologists (INR) to perform endovascular thrombectomy. As pilot for a national simulation study we examined ...
  • Trends in the prevalence of breastfeeding up to 6 months of age using structured data from routine child healthcare visits 

    Revheim, Ingrid; Balthasar, Melissa Rajini; Akerkar, Rupali Rajendra; Stangenes, Kristine Marie; Almenning, Grethe; Nygaard, Eva; Markestad, Trond Jacob; Øverland, Simon Nygaard; Roelants, Mathieu; Juliusson, Pétur Benedikt (Journal article; Peer reviewed, 2022)
    Aim The Norwegian Action Plan for a Healthier Diet (2017–2021) set the target that 25% of infants should be exclusively breastfed for 6 months by 2022. Our aim was to determine trends in the prevalence and duration of ...
  • Seven-year trajectories of body weight, quality of life and comorbidities following Roux-en-Y gastric bypass and sleeve gastrectomy 

    Nielsen, Hans Jørgen; Nedrebø, Bjørn Gunnar; Fosså, Alexander; Andersen, John Roger; Assmus, Jörg; Dagsland, Vigdis Halvorsen; Dankel, Simon N; Gudbrandsen, Oddrun Anita; Fernø, Johan; Hjellestad, Iren Drange; Hjermstad, Marianne Jensen; Kolotkin, Ronette Loganzo; Thorsen, Håvard Luong; Mellgren, Gunnar; Flølo, Tone Nygaard (Journal article; Peer reviewed, 2022)
    Background/objectives There is limited long-term data comparing the outcomes of sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) for severe obesity, both with respect to body weight, quality of life (QOL) and ...

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