• Pellino-2 in nonimmune cells: novel interaction partners and intracellular localization 

  Cristea, Ileana; Bruland, Ove; Rødahl, Eyvind; Bredrup, Cecilie (Journal article; Peer reviewed, 2021)

  Pellino-2 is an E3 ubiquitin ligase that mediates intracellular signaling in innate immune pathways. Most studies of endogenous Pellino-2 have been performed in macrophages, but none in nonimmune cells. Using yeast two-hybrid ...

• Ultrasound and Microbubbles Enhance Uptake of Doxorubicin in Murine Kidneys 

  Eikrem, Øystein Solberg; Kotopoulis, Spiros; Popa, Mihaela-Lucia; Safont, Mireia Mayoral; Fossan, Kjell Ove; Leh, Sabine; Landolt, Lea; Babickova, Janka; Gudbrandsen, Oddrun Anita; Gilja, Odd Helge; Riedel, Bettina Maria Ingeborg; Schjøtt, Jan Didrik; McCormack, Emmet; Marti, Hans-Peter (Journal article; Peer reviewed, 2021-11-29)

  The use of ultrasound and microbubble-enhanced drug delivery, commonly referred to as sonoporation, has reached numerous clinical trials and has shown favourable results. Nevertheless, the microbubbles and acoustic path ...

• Multiple simultaneous embolic cerebral infarctions 11 months after COVID-19 

  Advani, Rajiv; Strømsnes, Torbjørn Austveg; Stjernstrøm, Espen; Lugg, Sebastian T. (Journal article; Peer reviewed, 2021-08-18)

  Background: The coronavirus disease (COVID-19) pandemic has led to an unprecedented worldwide burden of disease. However, little is known of the longer-term implications and consequences of COVID-19. One of these may be a ...

• Pellino-2 intracellular localization and inflammasome overactivation in skin and corneal disease 

  Cristea, Ileana (Doctoral thesis, 2021-12-17)

  Background: Ocular pterygium-digital keloids dysplasia (OPDKD) is a rare, genetic disorder characterized by early onset corneal overgrowth and later development of keloids on distal limbs. We identified a de novo PELI2 ...

• Cabozantinib is effective in melanoma brain metastasis cell lines and affects key signaling pathways 

  Mannsåker, Trond Are; Hoang, Tuyen; Aasen, Synnøve Nymark; Bjørnstad, Ole Vidhammer; Parajuli, Himalaya; Sundstrøm, Terje; Thorsen, Frits (Journal article; Peer reviewed, 2021-11-14)

  Melanomas have a high potential to metastasize to the brain. Recent advances in targeted therapies and immunotherapies have changed the therapeutical landscape of extracranial melanomas. However, few patients with melanoma ...

• Prediction of type 1 diabetes at birth: Cord blood metabolites vs genetic risk score in the Norwegian mother, father, and child cohort 

  Tapia, German; Suvitaival, Tommi; Ahonen, Linda; Lund-Blix, Nicolai Andre; Njølstad, Pål Rasmus; Joner, Geir; Skrivarhaug, Torild; Legido-Quigley, Cristina; Størdal, Ketil; Stene, Lars Christian Mørch (Journal article; Peer reviewed, 2021)

  Background and aim: Genetic markers are established as predictive of type 1 diabetes, but unknown early life environment is believed to be involved. Umbilical cord blood may reflect perinatal metabolism and exposures. We ...

• Acetaminophen use during pregnancy and offspring attention deficit hyperactivity disorder - a longitudinal sibling control study 

  Gustavson, Kristin; Ystrøm, Eivind; Ask, Helga; Torvik, Fartein Ask; Hornig, Mady; Susser, Ezra; Lipkin, Ian; Lupattelli, Angela; Stoltenberg, Camilla; Magnus, Per Minor; Mjaaland, Siri; Askeland, Ragna Bugge; Walle, Kjersti Mæhlum; Bresnahan, Michaeline; Nordeng, Hedvig Marie Egeland; Reichborn-Kjennerud, Ted (Journal article, 2021)

  Background: Maternal acetaminophen use during pregnancy is associated with increased risk of ADHD in the child. This could reflect causal influence of acetaminophen on fetal neurodevelopment or could be due to confounding ...

• Social determinants and changes in energy drink consumption among adolescents in Norway, 2017-2019: a cross-sectional study 

  Kaldenbach, Siri; Strand, Tor Arne; Solvik, Beate Stokke; Holten-Andersen, Mads Nikolaj (Journal article; Peer reviewed, 2021)

  Objectives: To describe the social determinants and development in energy drink consumption among Norwegian adolescents in 2017, 2018 and 2019. Design: Cross-sectional, online, annual, nationwide surveys (Ungdata). ...

• Chronically elevated exogenous glucose elicits antipodal effects on the proteome signature of differentiating human iPSC-derived pancreatic progenitors 

  Ghila, Luiza; Legøy, Thomas Aga; Mathisen, Andreas Frøslev; Abadpour, Shadab; Paulo, Joao A.; Scholz, Hanne Bjørnson; Ræder, Helge; Chera, Simona (Journal article; Peer reviewed, 2021-04-02)

  The past decade revealed that cell identity changes, such as dedifferentiation or transdifferentiation, accompany the insulin-producing β-cell decay in most diabetes conditions. Mapping and controlling the mechanisms ...

• Sex disparity in acute myeloid leukaemia with FLT3 internal tandem duplication mutations: implications for prognosis 

  Hellesøy, Monica; Engen, Caroline Benedicte Nitter; Grob, Tim; Löwenberg, Bob; Valk, Peter J. M.; Gjertsen, Bjørn T. (Journal article; Peer reviewed, 2021)

  Incidence, molecular presentation and outcome of acute myeloid leukaemia (AML) are influenced by sex, but little attention has been directed at untangling sex-related molecular and phenotypic differences between female and ...

• One chance to get it right: Improving clinical handovers for better symptom control at the end of life 

  Goldraij, Gabriel; Tripodoro, Vilma Adriana; Aloisio, Melisa; Castro, Sandra Analiá; Gerlach, Christina; Mayland, Catriona Rachel; Haugen, Dagny Renata Faksvåg (Journal article; Peer reviewed, 2021)

  Poor communication contributes to morbidity and mortality, not only in general medical care but also at the end oflife. This leads to issues relating to symptom control and quality of care. As part of an international ...

• A human iPSC-astroglia neurodevelopmental model reveals divergent transcriptomic patterns in schizophrenia 

  Szabo, Attila; Akkouh, Ibrahim Ahmed; Vandenberghe, Matthieu; Osete, Jordi Requena; Hughes, Timothy; Heine, Vivi M.; Smeland, Olav Bjerkehagen; Glover, Joel Clinton; Andreassen, Ole; Djurovic, Srdjan (Journal article; Peer reviewed, 2021)

  While neurodevelopmental abnormalities have been associated with schizophrenia (SCZ), the role of astroglia in disease pathophysiology remains poorly understood. In the present study, we used a human induced pluripotent ...

• Genetic association study of childhood aggression across raters, instruments, and age 

  Ip, Hill F.; van der Laan, Camiel M.; Krapohl, Eva M. L.; Brikell, Isabell; Sánchez-Mora, Cristina; Nolte, Ilja M.; Pourcain, Beate St; Bolhuis, Koen; Palviainen, Teemu; Zafarmand, Hadi; Colodro-Conde, Lucía; Gordon, Scott; Zayats, Tetyana; Aliev, Fazil; Jiang, Chang; Wang, Carol A.; Saunders, Gretchen; Karhunen, Ville; Hammerschlag, Anke R.; Adkins, Daniel E.; Border, Richard; Peterson, Roseann E.; Prinz, Joseph A.; Thiering, Elisabeth; Seppälä, Iikka; Vilor-Tejedor, Natàlia; Ahluwalia, Tarunveer S.; Day, Felix R.; Hottenga, Jouke-Jan; Allegrini, Andrea G.; Rimfeld, Kaili; Chen, Qi; Yi, Lu; Martin, Joanna; Soler Artigas, Marìa; Rovira, Paula; Bosch, Rosa; Español, Gemma; Ramos-Quiroga, Josep Antonio; Neumann, Alexander; Haavik, Jan; Harris, Jennifer Ruth; Helgeland, Øyvind; Johansson, Stefan; Knudsen, Gun Peggy Strømstad; Njølstad, Pål Rasmus; Havdahl, Alexandra; Magnus, Per Minor; Reichborn-Kjennerud, Ted; Boomsma, Dorret I. (Journal article; Peer reviewed, 2021)

  Childhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from ...

• A whole blood based resuscitation strategy in civilian medical services: Experience from a Norwegian hospital in the period 2017–2020 

  Hagen, Kristin Gjerde; Strandenes, Geir; Kristoffersen, Einar Klæboe; Braathen, Hanne; Sivertsen, Joar; Bjerkvig, Christopher Kalhagen; Sommerfelt-Pettersen, Nina Grindheim; Aasheim, Irmelin Beathe; Lunde, Turid Helen Felli; Hervig, Tor; Apelseth, Torunn Oveland (Journal article; Peer reviewed, 2021)

  Background: Civilian and military guidelines recommend early balanced transfusion to patients with life-threatening bleeding. Low titer group O whole blood was introduced as the primary blood product for resuscitation of ...

• Gender Differences in Kidney Stone Disease (KSD): Findings from a Systematic Review 

  Gillams, Kathryn; Jones, Patrick; Juliebø, Siri Øvereng; Somani, Bhaskar K. (Journal article; Peer reviewed, 2021)

  Purpose of review: The prevalence of kidney stones is rising and historically carries a preponderance for males. However, recent evidence has questioned whether this gender gap is closing. The aim of this systematic review ...

• Temperature-dependent autoactivation associated with clinical variability of PDGFRB Asn666 substitutions 

  Bredrup, Cecilie; Cristea, Ileana; Safieh, Leen Abu; Di Maria, Emilio; Gjertsen, Bjørn Tore; Tveit, Kåre Steinar; Thu, Frode; Bull, Nils; Edward, Deepak P.; Hennekam, Raoul C.; Høvding, Gunnar Jr; Haugen, Olav H.; Houge, Gunnar Douzgos; Rødahl, Eyvind; Bruland, Ove (Journal article; Peer reviewed, 2021)

  Ocular pterygium-digital keloid dysplasia (OPDKD) presents in childhood with ingrowth of vascularized connective tissue on the cornea leading to severely reduced vision. Later the patients develop keloids on digits but are ...

• Vitamin B status and association with antiseizure medication in pregnant women with epilepsy 

  Husebye, Elisabeth Synnøve Nilsen; Riedel, Bettina Maria Ingeborg; Monsen, Anne-Lise Bjørke; Spigset, Olav; Daltveit, Anne Kjersti Nesje; Gilhus, Nils Erik; Bjørk, Marte-Helene (Journal article; Peer reviewed, 2021)

  Objective Antiseizure medication (ASM) use interacts with vitamin B status in nonpregnant epilepsy populations. We aimed to examine the association between ASM and vitamin B status in pregnant women with epilepsy. Methods ...

• Challenges and possible solutions in cross-disciplinary and cross-sectorial research teams within the domain of e-mental health 

  Nordgreen, Tine; Rabbi, Fazle; Tørresen, Jim; Skar, Yngvar Sigmund; Guribye, Frode; Inal, Yavuz; Flobak, Eivind; Wake, Jo Dugstad; Mukhiya, Suresh Kumar; Aminifar, Amin; Myklebost, Sunniva Brurok; Lundervold, Astri J.; Kenter, Robin Maria Francisca; Hammar, Åsa Karin; Kahlon, Smiti; Nordby, Emilie; Sekse, Ragnhild Johanne Tveit; Griffin, Kristine Fonnes; Jakobsen, Petter; Pham, Hoang Minh; Côté-Allard, Ulysse Teller Masao; Noori, Farzan Majeed; Lamo, Yngve (Journal article; Peer reviewed, 2021)

  Purpose: Mental illness presents a huge individual, societal and economic challenges, currently accounting for 20% of the worldwide burden of disease. There is a gap between the need for and access to services. Digital ...

• CRMP5 Antibodies—Diagnostic Challenges 

  Totland, Cecilie; Haugen, Mette; Vedeler, Christian Alexander (Journal article; Peer reviewed, 2021-09-22)

  CRMP5-associated paraneoplastic neurological syndromes (PNS) are rare, and only few studies describe larger cohorts of patients with CRMP5 antibodies. We have included 24 patients with CRMP5 antibodies and compared clinical ...

• Profiling and functional analysis of microRNA deregulation in cancer-associated fibroblasts in oral squamous cell carcinoma depicts an anti-invasive role of microRNA-204 via regulation of their motility 

  Rajthala, Saroj; Min, Anjie; Parajuli, Himalaya; Debnath, Kala Chand; Ljøkjel, Borghild; Hoven, Kristin Marie; Kvalheim, Arild; Lybak, Stein; Neppelberg, Evelyn; Vintermyr, Olav Karsten; Johannessen, Anne Christine; Sapkota, Dipak; Costea, Daniela Elena (Journal article; Peer reviewed, 2021-11-04)

  Background: Knowledge on the role of miR changes in tumor stroma for cancer progression is limited. This study aimed to investigate the role of miR dysregulation in cancer-associated fibroblasts (CAFs) in oral squamous ...

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