• Maternal and offspring genetic risk score analyses of fetal alcohol exposure and attention-deficit hyperactivity disorder risk in offspring 

  Haan, Elis; Sallis, Hannah M.; Ystrøm, Eivind; Njølstad, Pål Rasmus; Andreassen, Ole Andreas; Reichborn-Kjennerud, Ted; Munafo, Marcus R.; Havdahl, Alexandra; Zuccolo, Luisa (Journal article; Peer reviewed, 2021)

  Background: Studies investigating the effects of prenatal alcohol exposure on childhood attention-deficit hyperactivity disorder (ADHD) symptoms using conventional observational designs have reported inconsistent findings, ...

• Characterising the shared genetic determinants of bipolar disorder, schizophrenia and risk-taking 

  Hindley, Guy Frederick Lanyon; Bahrami, Shahram; Steen, Nils Eiel; O'Connell, Kevin Sean; Frei, Oleksandr; Shadrin, Alexey; Bettella, Francesco; Rødevand, Linn; Fan, Chun-Chieh; Dale, Anders; Djurovic, Srdjan; Smeland, Olav Bjerkehagen; Andreassen, Ole (Journal article; Peer reviewed, 2021)

  Increased risk-taking is a central component of bipolar disorder (BIP) and is implicated in schizophrenia (SCZ). Risky behaviours, including smoking and alcohol use, are overrepresented in both disorders and associated ...

• Role of a Digital Clinical Decision–Support System in General Practitioners’ Management of COPD in Norway 

  Vijayakumar, Varun Kumar; Mustafa, Tehmina; Nore, Bjarte Kjell; Garatun-Tjeldstø, Kjell Yngvar; Næss, Øystein; Johansen, Odd Erik; Aarli, Bernt Bøgvald (Journal article; Peer reviewed, 2021)

  Background: The study investigated if a web-based clinical decision–support system (CDSS) tool would improve general practitioners’ (GPs) accuracy of diagnosis and classification of patients with chronic obstructive pulmonary ...

• Nationwide audit and feedback on implementation of antibiotic stewardship programmes in Norwegian hospitals 

  Skodvin, Brita; Høgli, June Utnes; Gravningen, Kirsten Midttun; Neteland, Marion Iren; Harthug, Stig; Akselsen, Per Espen (Journal article; Peer reviewed, 2021)

  Background Implementation of antibiotic stewardship programmes (ASPs) in hospitals is challenging and there is a knowledge gap on how to pursue this process efficiently. Objectives To evaluate whether audit and feedback ...

• Mortality and non-use of antipsychotic drugs after acute admission in schizophrenia: A prospective total-cohort study 

  Strømme, Maria Fagerbakke; Mellesdal, Liv Solrunn; Bartz-Johannesen, Christoffer; Kroken, Rune Andreas; Krogenes, Marianne; Mehlum, Lars; Johnsen, Erik (Journal article; Peer reviewed, 2021)

  Background In society at large, it is debated whether use of antipsychotic drugs is associated with increased or decreased mortality among patients with schizophrenia. Large register studies have demonstrated an increased ...

• Risk of Relapse Among Opioid‐Dependent Patients Treated With Extended‐Release Naltrexone or Buprenorphine‐Naloxone: A Randomized Clinical Trial 

  Opheim, Arild; Gaulen, Zhanna; Solli, Kristin Klemmetsby; Latif, Zill-E-Huma; Fadnes, Lars T.; Saltyte Benth, Jurate; Kunøe, Nikolaj; Tanum, Lars Håkon Reiestad (Journal article; Peer reviewed, 2021)

  Background and Objectives Compare the risk of relapse to heroin and other illicit opioids among opioid-dependent patients receiving treatment with extended-release naltrexone (XR-NTX) or buprenorphine-naloxone ...

• Unmet Surgical Need in Malawi 

  Varela, Carlos Gomes (Doctoral thesis, 2021-10-04)

  Introduction Globally, and especially in sub-Saharan Africa, including Malawi, surgical conditions receive a low level of priority in national health systems. The burden of surgical diseases is not well documented and the ...

• Dødsfall i sykehjem etter covid-19-vaksine 

  Wyller, Torgeir Bruun; Kittang, Bård Reiakvam; Ranhoff, Anette Hylen; Harg, Pernille; Myrstad, Marius (Journal article; Peer reviewed, 2021)

  Bakgrunn: I perioden 27.12.2020–15.2.2021 ble om lag 29 400 av Norges ca. 35 000 sykehjemspasienter vaksinert med mRNA-vaksinen BNT162b2. I samme tidsrom mottok Statens legemiddelverk 100 meldinger om mistenkte fatale ...

• Dental caries in children and adolescents with juvenile idiopathic arthritis and controls: a multilevel analysis 

  Gil, Elisabeth G.; Åstrøm, Anne-Kristine N; Lie, Stein Atle; Rygg, Marite; Fischer, Johannes; Rosén, Annika; Bletsa, Athanasia; Luukko, Keijo; Shi, Xie-Qi; Halbig, Josefine; Frid, Paula; Cetrelli, Lena Elisabet; Tylleskär, Karin; Rosendahl, Karen; Skeie, Marit Slåttelid (Journal article; Peer reviewed, 2021)

  Background Optimal utilization of dental caries data is crucial in epidemiological research of individuals with juvenile idiopathic arthritis (JIA). The aims were to: explore whether caries is more prevalent among children ...

• Agenda navigation in consultations covering multiple topics. A qualitative case study from general practice 

  Guassora, Ann Dorrit; Johansen, May-Lill; Malterud, Kirsti (Journal article; Peer reviewed, 2021)

  Objective To explore how agenda navigation may be accomplished underway in consultations covering multiple topics, we identified and analyzed one GP’s communicative strategies. Design, setting, and subjects A qualitative ...

• Studies of gene expression in the Parkinson’s disease brain 

  Dick, Fiona (Doctoral thesis, 2021-10-01)

  Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder, affecting ~1.8% of the population above 65 years. A combination of genetic and environmental factors contributes to the risk of PD, but the ...

• Novel preoperative biomarkers and evaluation of altered treatment strategies to improve outcome for endometrial cancer patients 

  Forsse, David (Doctoral thesis, 2021-10-01)

  Background: Endometrial cancer is the most common gynecological cancer among women in countries with a high developmental index, and the incidence is expected to rise. Major controversies in the treatment of endometrial ...

• Wavelet Screening identifies regions highly enriched for differentially methylated loci for orofacial clefts 

  Denault, William Robert Paul; Romanowska, Julia; Haaland, Øystein Ariansen; Lyle, Robert; Taylor, Jack A.; Xu, Zongli; Lie, Rolv T.; Gjessing, Håkon K.; Jugessur, Astanand (Journal article; Peer reviewed, 2021)

  DNA methylation is the most widely studied epigenetic mark in humans and plays an essential role in normal biological processes as well as in disease development. More focus has recently been placed on understanding ...

• Shared genetic architecture between neuroticism, coronary artery disease and cardiovascular risk factors 

  Torgersen, Kristin Stensland; Bahrami, Shahram; Frei, Oleksandr; Shadrin, Alexey; O'Connell, Kevin Sean; Smeland, Olav Bjerkehagen; Munkhaugen, John; Djurovic, Srdjan; Dammen, Toril; Andreassen, Ole A. (Journal article; Peer reviewed, 2021)

  Neuroticism is associated with poor health, cardiovascular disease (CVD) risk factors and coronary artery disease (CAD). The conditional/conjunctional false discovery rate method (cond/conjFDR) was applied to genome wide ...

• Preference-based instrumental variables in health research rely on important and underreported assumptions: a systematic review 

  Widding-Havneraas, Tarjei; Chaulagain, Ashmita; Lyhmann, Ingvild; Zachrisson, Henrik Daae; Elwert, Felix; Markussen, Simen; McDaid, David; Mykletun, Arnstein (Journal article; Peer reviewed, 2021)

  Objective: Preference-based instrumental variables (PP IV) designs can identify causal effects when patients receive treatment due to variation in providers’ treatment preference. We offer a systematic review and methodological ...

• 1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans 

  Sønderby, Ida Elken; van der Meer, Dennis; Moreau, Clara; Kaufmann, Tobias; Walters, G. Bragi; Ellegaard, Maria; Abdellaoui, Abdel; Ames, David; Amunts, Katrin; Andersson, Micael; Armstrong, Nicola J.; Bernard, Manon; Blackburn, Nicholas B.; Blangero, John; Boomsma, Dorret I.; Brodaty, Henry; Brouwer, Rachel M.; Bülow, Robin; Bøen, Rune; Cahn, Wiepke; Calhoun, Vince D.; Caspers, Svenja; Ching, Christopher R. K.; Cichon, Sven; Ciufolini, Simone; Crespo-Facorro, Benedicto; Curran, Joanne E.; Dale, Anders M.; Dalvie, Shareefa; Dazzan, Paola; de Geus, Eco J. C.; Zubicaray, Greig I. de; Zwarte, Sonja M. C. de; Desrivieres, Sylvane; Doherty, Joanne L.; Donohoe, Gary; Draganski, Bogdan; Ehrlich, Stefan; Eising, Else; Espeseth, Thomas; Fejgin, Kim; Fisher, Simon E.; Fladby, Tormod; Frei, Oleksandr; Frouin, Vincent; Fukunaga, Masaki; Gareau, Thomas; Ge, Tian; Glahn, David C.; Grabe, Hans J.; Groenewold, Nynke A.; Gustafsson, Omar; Haavik, Jan; Haberg, Asta Kristine; Hall, Jeremy; Hashimoto, Ryota; Hehir-Kwa, Jayne Y.; Hibar, Derrek P.; Hillegers, Manon H. J.; Hoffmann, Per; Holleran, Laurena; Holmes, Avram J.; Johansson, Stefan; Jönsson, Erik Gunnar; Hellard, Stephanie Francoise Claire Le; Lundervold, Arvid; Lundervold, Astri J.; Moberget, Torgeir; Nordvik, Jan Egil; Sando, Sigrid Botne; Steen, Vidar Martin; Tamnes, Christian Krog; Agartz, Ingrid; Djurovic, Srdjan; Westlye, Lars Tjelta; Andreassen, Ole; Homuth, Georg; Hottenga, Jouke-Jan; Hulshoff Pol, Hilleke E.; Ikeda, Masashi; Jahanshad, Neda; Jockwitz, Christiane; Jørgensen, Niklas R.; Kikuchi, Masataka; Knowles, Emma E. M.; Kumar, Kuldeep; Leu, Costin; Linden, David E. J.; Liu, Jingyu; Maillard, Anne M.; Martin, Nicholas G.; Martin-Brevet, Sandra; Mather, Karen A.; Mathias, Samuel R.; McMahon, Katie L.; McRae, Allan F.; Medland, Sarah E.; Meyer-Lindenberg, Andreas; Modenato, Claudia; Monereo Sánchez, Jennifer; Morris, Derek W.; Mühleisen, Thomas W.; Murray, Robin M.; Nielsen, Jacob; Nyberg, Lars; Olde Loohuis, Loes M.; Ophoff, Roel A.; Owen, Michael J.; Paus, Tomas; Pausova, Zdenka; Peralta, Juan M.; Pike, G. Bruce; Prieto, Carlos; Quinlan, Erin B.; Reinbold, Céline S.; Reis Marques, Tiago; Rucker, James J. H.; Sachdev, Perminder S.; Schofield, Peter R.; Schork, Andrew J.; Schumann, Gunter; Shin, Jean; Shumskaya, Elena; Silva, Ana I.; Sisodiya, Sanjay M.; Stein, Dan J.; Strike, Lachlan T.; Suzuki, Ikuo K.; Teumer, Alexander; Thalamuthu, Anbupalam; Tordesillas-Gutiérrez, Diana; Uhlmann, Anne; Ulfarsson, Magnus O.; van ‘t Ent, Dennis; van den Bree, Marianne B. M.; Vanderhaeghen, Pierre; Vassos, Evangelos; Wen, Wei; Wittfeld, Katharina; Wright, Margaret J.; Stefansson, Hreinn; Stefansson, Kari; Jacquemont, Sébastien; Thompson, Paul M. (Journal article; Peer reviewed, 2021)

  Low-frequency 1q21.1 distal deletion and duplication copy number variant (CNV) carriers are predisposed to multiple neurodevelopmental disorders, including schizophrenia, autism and intellectual disability. Human carriers ...

• Derivation and Molecular Characterization of a Morphological Subpopulation of Human iPSC Astrocytes Reveal a Potential Role in Schizophrenia and Clozapine Response 

  Akkouh, Ibrahim; Hribkova, Hana; Grabiec, Marta; Budinska, Eva; Szabo, Attila; Kasparek, Tomas; Andreassen, Ole Andreas; Sun, Yuh-Man; Djurovic, Srdjan (Journal article; Peer reviewed, 2021)

  Astrocytes are the most abundant cell type in the human brain and are important regulators of several critical cellular functions, including synaptic transmission. Although astrocytes are known to play a central role in ...

• Role of integrin α11β1 in breast cancer 

  Smeland, Hilde Ytre-Hauge (Doctoral thesis, 2021-09-24)

  Breast cancer cells are strongly influenced by a complex tumor microenvironment comprised of a diversity of stromal cells, including a heterogeneous population of cancer associated fibroblasts (CAFs), in addition to the ...

• Gastric dysmotility and visceral hypersensitivity – an ultrasound approach to functional GI disorders and diabetic gastroparesis 

  Steinsvik, Elisabeth Kjelsvik (Doctoral thesis, 2021-09-24)

  Background: Functional dyspepsia (FD), irritable bowel syndrome (IBS) and diabetic gastroparesis (DG) are conditions with overlapping symptoms and motility characteristics. The objective of this dissertation was to investigate ...

• Association between complement component 4A expression, cognitive performance and brain imaging measures in UK Biobank 

  O'Connell, Kevin S.; Sønderby, Ida Elken; Frei, Oleksandr; van der Meer, Dennis; Athanasiu, Lavinia; Smeland, Olav Bjerkehagen; Alnæs, Dag; Kaufmann, Tobias; Westlye, Lars Tjelta; Steen, Vidar Martin; Andreassen, Ole Andreas; Hughes, Timothy; Djurovic, Srdjan (Journal article; Peer reviewed, 2021)

  Background Altered expression of the complement component C4A gene is a known risk factor for schizophrenia. Further, predicted brain C4A expression has also been associated with memory function highlighting that altered ...

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