Recent Submissions

  • Antiemetic treatment of hyperemesis gravidarum in 1,064 Norwegian women and the impact of European warning on metoclopramide: a retrospective cohort study 2002–2019 

    Erdal, Hilde; Holst, Lone; Heitmann, Kristine; Trovik, Jone (Journal article; Peer reviewed, 2022-06-02)
    Background: Women suffering from severe nausea and vomiting during pregnancy, hyperemesis gravidarum, have poor quality of life and increased risk of potentially fatal maternal and fetal complications. There is increasing ...
  • Analysis of host-pathogen gene association networks reveals patient-specific response to streptococcal and polymicrobial necrotising soft tissue infections 

    Jahagirdar, Sanjeevan; Morris, Lorna; Benis, Nirupama; Oppegaard, Oddvar; Svenson, Mattias; Hyldegaard, Ole; Skrede, Steinar; Norrby-Teglund, Anna; Bruun, Trond; Rath, Eivind; Nedrebø, Torbjørn; Arnell, Per; Rosen, Anders; Hedetoft, Morten; Madsen, Martin B.; Svensson, Mattias; Snäll, Johanna; Karlsson, Ylva; Nekludov, Michael; Martins dos Santos, Vitor A. P.; Saccenti, Edoardo (Journal article; Peer reviewed, 2022)
    Background: Necrotising soft tissue infections (NSTIs) are rapidly progressing bacterial infections usually caused by either several pathogens in unison (polymicrobial infections) or Streptococcus pyogenes (mono-microbial ...
  • Transcriptomic Profiling Reveals That HMGB1 Induces Macrophage Polarization Different from Classical M1 

    Qu, Heshuang; Heinbäck, Rebecka; Salo, Henna; Ewing, Ewoud; Espinosa, Alexander; Aulin, Cecilia; Harris, Anna Helena Erlandsson (Journal article; Peer reviewed, 2022-06-02)
    Macrophages are key inflammatory immune cells that display dynamic phenotypes and functions in response to their local microenvironment. In different conditions, macrophage polarization can be induced by high-mobility group ...
  • Shared genetic loci between depression and cardiometabolic traits 

    Torgersen, Kristin Stensland; Rahman, Zillur; Bahrami, Shahram; Hindley, Guy Frederick Lanyon; Parker, Nadine; Frei, Oleksandr; Shadrin, Alexey; O'Connell, Kevin Sean; Tesli, Martin Steen; Smeland, Olav Bjerkehagen; Munkhaugen, John; Djurovic, Srdjan; Dammen, Toril; Andreassen, Ole (Journal article; Peer reviewed, 2022-05-13)
    Epidemiological and clinical studies have found associations between depression and cardiovascular disease risk factors, and coronary artery disease patients with depression have worse prognosis. The genetic relationship ...
  • Neuronal Dysfunction Is Linked to the Famine-Associated Risk of Proliferative Retinopathy in Patients With Type 2 Diabetes 

    Fedotkina, Olena; Jain, Ruchi; Prasad, Rashmi B.; Luk, Andrea; García-Ramírez, Marta; Özgümüs, Türküler; Cherviakova, Liubov; Khalimon, Nadiya; Svietleisha, Tetiana; Buldenko, Tetiana; Kravchenko, Victor; Jain, Deepak; Vaag, Allan; Chan, Juliana; Khalangot, Mykola D.; Hernández, Cristina; Nilsson, Peter M.; Simo, Rafael; Artner, Isabella; Lyssenko, Valeriya (Journal article; Peer reviewed, 2022-05-05)
    Persons with type 2 diabetes born in the regions of famine exposures have disproportionally elevated risk of vision-threatening proliferative diabetic retinopathy (PDR) in adulthood. However, the underlying mechanisms are ...
  • Clonal evolution after treatment pressure in multiple myeloma: heterogenous genomic aberrations and transcriptomic convergence 

    Misund, Kristine; Hofste op Bruinink, Davine; Coward, Eivind; Hoogenboezem, Remco M.; Rustad, Even Holth; Sanders, Mathijs A.; Rye, Morten Beck; Sponaas, Anne-Marit; van der Holt, Bronno; Zweegman, Sonja; Hovig, Eivind; Meza, Leonardo Zepeda; Sundan, Anders; Myklebost, Ola; Sonneveld, Pieter; Waage, Anders (Journal article; Peer reviewed, 2022)
    We investigated genomic and transcriptomic changes in paired tumor samples of 29 in-house multiple myeloma (MM) patients and 28 patients from the MMRF CoMMpass study before and after treatment. A change in clonal composition ...
  • Auxilin is a novel susceptibility gene for congenital heart block which directly impacts fetal heart function 

    Meisgen, Sabrina; Hedlund, Malin; Ambrosi, Aurelie; Folkersen, Lasse; Ottosson, Vijole; Forsberg, David; Thorlacius, Gudny Ella; Biavati, Luca; Strandberg, Linn; Mofors, Johannes; Ramskold, Daniel; Ruhrmann, Sabrina; Meneghel, Lauro; Nyberg, William; Espinosa, Alexander; Hamilton, Robert Murray; Franco-Cereceda, Anders; Hamsten, Anders; Olsson, Tomas; Greene, Lois; Eriksson, Per; Gemzell-Danielsson, Kristina; Salomonsson, Stina; Kuchroo, Vijay K; Herlenius, Eric; Kockum, Ingrid; Sonesson, Sven-Erik; Herlenius, Marie Elisabeth Wahren (Journal article; Peer reviewed, 2022)
    Objective: Neonatal lupus erythematosus (NLE) may develop after transplacental transfer of maternal autoantibodies with cardiac manifestations (congenital heart block, CHB) including atrioventricular block, atrial and ...
  • The value of histological examination in the diagnosis of tuberculous lymphadenitis in the era of rapid molecular diagnosis 

    Tahseen, Sabira; Ambreen, Atiqa; Ishtiaq, Sheeba; Khanzada, Faisal M.; Safdar, Nauman; Sviland, Lisbet; Mustafa, Tehmina (Journal article; Peer reviewed, 2022)
    Extrapulmonary tuberculosis often poses a diagnostic challenge. This study aimed to assess the value of histological examination in diagnosing tuberculous lymphadenitis (LNTB) when performed simultaneously with rapid ...
  • Islet cell replacement and transplantation immunology in a mouse strain with inducible diabetes 

    Bhagchandani, Preksha; Chang, Charles A.; Zhao, Weichen; Ghila, Luiza Mihaela; Herrera, Pedro L.; Chera, Simona; Kim, Seung K. (Journal article; Peer reviewed, 2022)
    Improved models of experimental diabetes are needed to develop cell therapies for diabetes. Here, we introduce the B6 RIP-DTR mouse, a model of experimental diabetes in fully immunocompetent animals. These inbred mice ...
  • Prematur ovarialinsuffisiens 

    Vogt, Elinor Margrethe Chelsom; Russell, Hannah Ni Bhriain; Øksnes, Marianne; Lund, Agnethe (Journal article; Peer reviewed, 2022)
    Prematur ovarialinsuffisiens defineres som tap av ovariefunksjon før 40 års alder og er en kompleks tilstand med heterogen etiologi. Tidlig diagnose og igangsetting av hormonerstattende behandling er viktig for å lindre ...
  • Radiation induced brain necrosis after proton therapy for head and neck cancer 

    Engeseth, Grete May (Doctoral thesis, 2022-12-09)
    Protonterapi gir reduksjon i normalvevsdoser sammenlignet med strålebehandling med fotoner, og det er antatt at dette vil resultere i en lavere forekomst av stråleinduserte seinskader. For å kompensere for en økt biologisk ...
  • Physician participation in quality improvement work- interest and opportunity: a cross-sectional survey 

    Deilkås, Ellen C Tveter; Rosta, Judith; Baathe, Fredrik; Søfteland, Eirik; Lexberg, Åse; Røise, Olav; Isaksson Rø, Karin Elisabet (Journal article; Peer reviewed, 2022-10-25)
    Background: Lack of physician involvement in quality improvement threatens the success and sustainability of quality improvement measures. It is therefore important to assess physicians´ interests and opportunities to be ...
  • Geographical variation in orthopedic procedures in Norway: Cross-sectional population-based study 

    Holsen, Maria; Hovind, Veronica; Bedane, Haji Kedir; Osvoll, Knut Ivar; Gjertsen, Jan-Erik; Furnes, Ove Nord; Walsh, Mary E.; Ingebrigtsen, Tor (Journal article; Peer reviewed, 2022)
    Background: Standardized surgery rates for common orthopedic procedures vary across geographical areas in Norway. We explored whether area-level factors related to demand and supply in publicly funded healthcare are ...
  • MRI adipose tissue segmentation and quantification in R (RAdipoSeg) 

    Haugen, Christine; Lysne, Vegard; Haldorsen, Ingfrid S.; Tjora, Erling; Gudbrandsen, Oddrun Anita; Sagen, Jørn Vegard; Dankel, Simon N; Mellgren, Gunnar (Journal article; Peer reviewed, 2022-10-08)
    Background: Excess adipose tissue is associated with increased cardiovascular and metabolic risk, but the volume of visceral and subcutaneous adipose tissue poses different metabolic risks. MRI with fat suppression can be ...
  • Assessment of Small Bowel Motility and SMA Blood Flow Studied with Transabdominal Ultrasound 

    Nylund, Kim; Gjengsto, Andreas Jessen; Volkmann, Hilde Løland Von; Gilja, Odd Helge (Journal article; Peer reviewed, 2022)
    Purpose: Gastrointestinal ultrasound (GIUS) is a noninvasive imaging technique that may be used to study physiological changes in the small bowel. The aim of the study was to investigate the feasibility of measuring blood ...
  • Hypersementose og endodontiske implikasjoner 

    Zakariyya, Gunel; Fristad, Inge (Journal article; Peer reviewed, 2022)
    Hypersementose er forbundet med lokale og systemiske faktorer, men etiologien er ikke godt kartlagt. Vanskeligheter med å bedømme røntgenologisk tykkelse på sementlaget ved hypersementose, vil direkte kunne påvirke beslutning ...
  • Impact of rapid molecular testing on diagnosis, treatment and management of community-acquired pneumonia in Norway: a pragmatic randomised controlled trial (CAPNOR) 

    Serigstad, Sondre; Ritz, Christian; Faurholt-Jepsen, Daniel; Markussen, Dagfinn Lunde; Ebbesen, Marit Helen; Kommedal, Øyvind; Bjørneklett, Rune Oskar; Heggelund, Lars; Clark, Tristan W.; van Werkhoven, Cornelis H.; Knoop, Siri Tandberg; Ulvestad, Elling; Grewal, Harleen (Journal article; Peer reviewed, 2022)
    Background: Community-acquired pneumonia (CAP) causes a large burden of disease. Due to difficulties in obtaining representative respiratory samples and insensitive standard microbiological methods, the microbiological ...
  • Dietary practices and nutritional status of young children in the former ensete monoculture dominated Sidama region, southern Ethiopia: A community based cross-sectional study 

    Kebede, Tsigereda Behailu; Mengesha, Selamawit; Lindtjorn, Bernt; Engebretsen, Ingunn Marie Stadskleiv (Journal article; Peer reviewed, 2022-09-14)
    Background: Child undernutrition is a challenge in Ethiopia, where morbidity and mortality among children are attributed to it. This study aimed to describe the dietary practices, household food insecurity, and nutritional ...
  • Assessing the Anti-Inflammatory Effects of an Orally Dosed Enzymatically Liberated Fish Oil in a House Dust Model of Allergic Asthma 

    Currie, Crawford; Framroze, Bomi; Singh, Dave; Lea, Simon; Bjerknes, Christian; Hermansen, Erland (Journal article; Peer reviewed, 2022-10-14)
    Eosinophils are a major driver of inflammation in a number of human diseases, including asthma. Biologic therapies targeting IL-5 have enabled better control of severe eosinophilic asthma, but no such advances have been ...
  • Health-related quality of life in patients with advanced melanoma treated with ipilimumab: prognostic implications and changes during treatment 

    Aamdal, Elin; Skovlund, Eva; Jacobsen, Kari Dolven; Straume, Oddbjørn; Kersten, Christian; Herlofsen, Oluf; Karlsen, Jarle; Hussain, Israr; Amundsen, Anita; Dalhaug, Astrid; Nyakas, Marta Sølvi; Hagene, Kirsten Thorin; Holmsen, Kjersti; Aamdal, Steinar; Kaasa, Stein; Guren, Tormod Kyrre; Kyte, Jon A (Journal article; Peer reviewed, 2022)
    Background: We have previously reported that the safety and efficacy of ipilimumab in real-world patients with metastatic melanoma were comparable to clinical trials. Few studies have explored health-related quality of ...

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