• No evidence of extensive non-CpG methylation in mtDNA 

  Guitton, Romain; Sanchez Nido, Gonzalo; Tzoulis, Charalampos (Journal article; Peer reviewed, 2022)

  While most research suggests mitochondrial DNA (mtDNA) harbors low or no methylation, a few studies claim to report evidence of high-level methylation in the mtDNA. The reasons behind these contradictory results are likely ...

• Studies of mtDNA epigenetics and structural integrity in health, aging, and Parkinson’s disease 

  Guitton, Romain (Doctoral thesis, 2025-06-05)

  Mitokondriell dysfunksjon er et kjennetegn ved aldring og nevrodegenerative sykdommer, inkludert Parkinsons sykdom (PD), men de underliggende mekanismene er fortsatt dårlig forstått. Et voksende interesseområde er mitokondriell ...

• Prediction of non-responders to oral appliance treatment of obstructive sleep apnea: a pilot study 

  Opsahl, Ulrik Leidland; Berge, Morten Eirik; Lehmann, Sverre; Bjorvatn, Bjørn; Johansson, Anders (Journal article; Peer reviewed, 2025)

  Purpose: Several clinically available variables have been identified as predictors of non-response to oral appliance (OA) treatment, including endotypical traits such as severe upper airway collapsibility, unstable ventilatory ...

• Measures to improve the treatment effect of oral appliance therapy in obstructive sleep apnea patients 

  Opsahl, Ulrik Leidland (Doctoral thesis, 2025-06-06)

  Obstruktiv søvnapné (OSA) er en utbredt søvnforstyrrelse assosiert med betydelig helserisiko, der behandling med apnéskinne (OA) er anerkjent hovedsakelig som andrelinjebehandling. Selv om OA-behandling er mye brukt, ...

• Lung function outcomes from childhood to adulthood after extremely preterm birth : Data from three population-based cohorts 

  Bårdsen, Tonje (Doctoral thesis, 2025-06-04)

  Bakgrunn: I perioden fra 1980 til 2000 skjedde det en enorm medisinsk utvikling i nyfødtmedisinen som førte til økende overlevelse for barn født ekstremt prematurt (EP), det vil i dette arbeidet si fødsel før 28 svangerskapsuker ...

• Chemokine associations with blood cerebrospinal fluid (CSF) barrier permeability and delirium 

  Denver, Paul; Tortorelli, Lucas; Hov, Karen Roksund; Berg, Jens Petter; Giil, Lasse Melvær; Nazmi, Arshed; Lopez-Rodriguez, Ana; Healy, Dáire; Murray, Carol; Barry, Robyn; Watne, Leiv; Cunningham, Colm (Journal article; Peer reviewed, 2025)

  Delirium is a highly prevalent neuropsychiatric syndrome characterised by acute and fluctuating impairments in attention and cognition. Mechanisms driving delirium are poorly understood but it has been suggested that blood ...

• Maternal seafood intake, dietary contaminant exposure, and risk of juvenile idiopathic arthritis: exploring gene-environment interactions 

  Dåstøl, Vilde Øverlien; Haftorn, Kristine Løkås; Rudsari, Hamid Khoshfekr; Jaholkowski, Piotr Pawel; Størdal, Ketil; Håberg, Siri Eldevik; Weinberg, Clarice R.; Rider, Lisa G.; Andreassen, Ole; Brantsæter, Anne Lise; Caspersen, Ida Henriette; Sanner, Helga (Journal article; Peer reviewed, 2024)

  Objectives: Juvenile idiopathic arthritis (JIA) originates from a complex interplay between genetic and environmental factors. We investigated the association between seafood intake and dietary contaminant exposure during ...

• Worldwide trends in the underweight and obesity from 1990 to 2022: a pooled analysis of 3,633 population-representative studies with 222 million school-aged children, adolescents, and adults 

  Ostojic, Sergej; Phelps, Nowell H.; Singleton, Rosie K.; Zhou, Bin; Heap, Rachel; Mishra, Anu; Bennett, James B.; Paciorek, Christopher J; Lhoste, Victor P.F.; Carillo-Larco, Rodrigo; Stevens, Gretchen A.; Rodriguez-Martinez, Andrea; Bixby, Honor; Bentham, James; Danaei, Mariachiara; Rayner, Archie; Barradas-Pires, Ana; Cowan, Melanie J; Savin, Stefan; Riley, Leanne M; Aguilar-Salinas, Carlos; Aryal, Krishna Kumar; Andersen, Lars Bo; Anderssen, Sigmund Alfred; Bere, Elling Tufte; Bergh, Ingunn Holden; Bjertness, Espen; Bjertness, Marius Bergsmark; Ekelund, Ulf; Gerdts, Eva; Grøholt, Else Karin; Haugsgjerd, Teresa Risan; Htet, Aung Soe; Igland, Jannicke; Janszky, Imre; Kjerpeseth, Lars Jøran; Kolle, Elin; Krokstad, Steinar; Madar, Ahmed Ali; Mathiesen, Ellisiv B.; Meisfjord, Jørgen Rajan; Meyer, Haakon Eduard; Sen, Abhijit; Sørgjerd, Elin Pettersen; Sparboe-Nilsen, Bente; Steene-Johannessen, Jostein; Steinsbekk, Silje; Sulo, Gerhard; Tell, Grethe S.; Torheim, Liv Elin; Vik, Frøydis Nordgård; Wichstrøm, Lars; Wilsgaard, Tom (Journal article; Peer reviewed, 2024)

  Background Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, ...

• Streptokinase reduces Streptococcus dysgalactiae subsp. equisimilis biofilm formation 

  Tölken, Lea A.; Neufend, Janine V.; Oppegaard, Oddvar; Methling, Karen; Moll, Kirsten; Redanz, Sylvio; Katsburg, Miriam M D; Ali, Murtadha Q.; Shumba, Patience; Kreikemeyer, Bernd; Skrede, Steinar; Fulde, Marcus; Norrby-Teglund, Anna; Lalk, Michael; Kittang, Bård Reiakvam; Siemens, Nikolai (Journal article; Peer reviewed, 2024)

  Background Streptococcus dysgalactiae subspecies equisimilis (SDSE) is increasingly recognized as an emerging cause of invasive diseases including necrotizing soft tissue infections (NSTIs). In contrast to the closely ...

• Clinical characteristics, treatment, and outcomes for elderly patients in a dedicated Covid-19 ward at a primary health care facility in western Norway: a retrospective observational study 

  Kittang, Bård Reiakvam; Øien, Ane Tveiten; Engtrø, Einar; Skjellanger, Marian; Krüger, Kjell (Journal article; Peer reviewed, 2024)

  Background The coronavirus pandemic has hit the oldest and frailest individuals hard, particularly patients and residents in nursing homes. In March 2020, we established a Covid-19 ward at a nursing home in Bergen, ...

• Pregnancy outcomes as related to in utero exposure to air pollution and greenness: The Life-GAP Project 

  Sinsamala, Robin Mzati; Johannessen, Ane; Bertelsen, Randi Jacobsen; Accordini, Simone; Brandt, Jørgen; Frohn, Lise Marie; Geels, Camilla; Thorarinn, Gislason; Holm, Mathias; Janson, Christer; Markevych, Iana; Orru, Hans; Gomez Real, Francisco; Sigsgaard, Torben; Skulstad, Svein Magne; Svanes, Cecilie; Marcon, Alessandro (Journal article; Peer reviewed, 2024)

  Background: Lower birth weight and preterm birth may increase the risk of adverse health outcomes later in life. We examined whether maternal exposure to air pollution and greenness during pregnancy is associated with ...

• Diabetes and Osteoarthritis: Exploring the Interactions and Therapeutic Implications of Insulin, Metformin, and GLP-1-Based Interventions 

  Halabitska, Iryna; Babinets, Liliia; Oksenych, Valentyn; Kamyshnyi, Oleksandr (Journal article; Peer reviewed, 2024-07-23)

  Diabetes mellitus (DM) and osteoarthritis (OA) are prevalent chronic conditions with shared pathophysiological links, including inflammation and metabolic dysregulation. This study investigates the potential impact of ...

• Genomic insight into COVID-19 severity in MAFLD patients: a single-center prospective cohort study 

  Buchynskyi, Mykhailo; Oksenych, Valentyn; Kamyshna, Iryna; Budarna, Olena; Halabitska, Iryna; Petakh, Pavlo; Kamyshnyi, Oleksandr (Journal article; Peer reviewed, 2024-09-04)

  This study investigated the influence of single nucleotide polymorphisms (SNPs) in genes associated with the interferon pathway (IFNAR2 rs2236757), antiviral response (OAS1 rs10774671, OAS3 rs10735079), and viral entry ...

• Beta-Blockers of Different Generations: Features of Influence on the Disturbances of Myocardial Energy Metabolism in Doxorubicin-Induced Chronic Heart Failure in Rats 

  Belenichev, Igor; Goncharov, Olexiy; Bukhtiyarova, Nina; Kuchkovskyi, Oleh; Ryzhenko, Victor; Makyeyeva, Lyudmyla; Oksenych, Valentyn; Kamyshnyi, Oleksandr (Journal article; Peer reviewed, 2024-08-28)

  Beta-blockers are first-line drugs in the treatment of chronic heart failure (CHF). However, there is no consensus on the specific effects of the beta-blockers of the I-III generation on energy metabolism in CHF. The aim ...

• Development and Optimization of Nasal Composition of a Neuroprotective Agent for Use in Neonatology after Prenatal Hypoxia 

  Belenichev, Igor; Aliyeva, Olena; Burlaka, Bogdan; Burlaka, Kristina; Kuchkovskyi, Oleh; Savchenko, Dmytro; Oksenych, Valentyn; Kamyshnyi, Oleksandr (Journal article; Peer reviewed, 2024-07-26)

  The intranasal route of drug administration is characterized by high bioavailability and is considered promising for rapid delivery of drugs with systemic action to the central nervous system (CNS), bypassing the blood-brain ...

• Dysregulation of miR-223, miR-146a, and miR-193a Expression Profile in Acute and Chronic Phases of Experimental Autoimmune Encephalomyelitis in C57BL/6 Mice 

  Gharibi, Saba; Moghimi, Bahram; Mahmoudi, Mohammad Bagher; Shahvazian, Ensieh; Yazd, Ehsan Farashahi; Yadegari, Maryam; Tahoori, Mohammad Taher; Yazdanpanah, Esmaeil; Haghmorad, Dariush; Oksenych, Valentyn (Journal article; Peer reviewed, 2024-09-06)

  Multiple sclerosis (MS) is a chronic autoimmune disease with an unknown etiology. The purpose of this research was to assess miR-223, miR-146a, and miR-193a in acute and chronic phases of experimental autoimmune encephalomyelitis ...

• Identification of Black Cumin (Nigella sativa) MicroRNAs by Next-Generation Sequencing and Their Implications in Secondary Metabolite Biosynthesis 

  Uriostegui-Pena, Andrea G.; Reyes-Calderón, Almendra; Gutiérrez-García, Claudia; Srivastava, Aashish; Sharma, Ashutosh; Paul, Sujay (Journal article; Peer reviewed, 2024-10-08)

  Secondary metabolites are bioactive compounds believed to contribute to the pharmacological properties of plants. MicroRNAs (miRNAs) are small non-coding RNA molecules involved in post-transcriptional regulation and are ...

• The association of premorbid conditions with 6-month mortality in acutely admitted ICU patients over 80 years 

  de Lange, Dylan W.; Soliman, Ivo W.; Leaver, Susannah; Boumendil, Ariane; Haas, Lenneke E. M.; Watson, Ximena; Boulanger, Carol; Szczeklik, Wojciech; Artigas, Antonio; Morandi, Alessandro; Andersen, Finn Husøy; Jung, Christian; Moreno, Rui; Walther, Sten M; Oeyen, Sandra; Schefold, Joerg C.; Cecconi, Maurizio; Marsh, Brian; Joannidis, Michael; Nalapko, Yuriy; Elhadi, Muhammed; Fjølner, Jesper; Guidet, Bertrand; Flaatten, Hans Kristian (Journal article; Peer reviewed, 2024)

  Background Premorbid conditions influence the outcome of acutely ill adult patients aged 80 years and over who are admitted to the ICU. The aim of this study was to determine the influence of such premorbid conditions ...

• Genetic association of antinuclear antibodies with HLA in JIA patients: a Swedish cohort study 

  Saleh, Raya; Sundberg, Erik; Olsson, Mia; Tengvall, Katarina; Alfredsson, Lars; Kockum, Ingrid; Padyukov, Leonid; Harris, Anna Helena Erlandsson (Journal article; Peer reviewed, 2024)

  Background Juvenile Idiopathic Arthritis (JIA) is a complex autoimmune disease and the most common chronic rheumatological disease affecting children under the age of 16. The etiology of JIA remains poorly understood, ...

• A Cross-Sectional Study of Peri-Implant Diseases in a Random Norwegian Population: Prevalence, Risk Indicators, and Clinical Validation of Patient-Reported Outcomes 

  Mauland, Erik Klepsland; Sørensen, Karoline; Aarbu, Naomi Østergren; Verket, Anders; Ellingsen, Stig Aanerød; Bull, Vibeke Hervik; Gaarden, Roya Torabi; Lie, Stein Atle; Bunæs, Dagmar Fosså (Journal article; Peer reviewed, 2024)

  Objectives The primary aim of this study was to investigate the prevalence of peri-implant diseases in a randomly selected Norwegian population. The secondary aims were to explore risk indicators for peri-implant diseases ...

View more