• The Role of apoptosis in suicide gene therapy of glioblastoma 

  Afroz, Shohana (Master thesis, 2021-12-01)

• Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores 

  de Rojas, Itziar; Moreno-Grau, Sonia; Tesi, Niccolo; Grenier-Boley, Benjamin; Andrade, Victor; Jansen, Iris E.; Rongve, Arvid; Aarsland, Dag; Selbæk, Geir; Saltvedt, Ingvild; Sando, Sigrid Botne; Djurovic, Srdjan; Andreassen, Ole; Pedersen, Nancy L.; Stringa, Najada; Zettergren, Anna; Hernández, Isabel; Montrreal, Laura; Antunez, Carmen; Antonell, Anna; Tankard, Rick; Bis, Joshua C.; Sims, Rebecca; Bellenguez, Celine; Quintela, Inés; González-Pérez, Antonio; Calero, Miguel; Franco-Macias, Emilio; Macias, Juan; Blesa, Rafael; Cervera-Carles, Laura; Menendez-Gonzalez, Manuel; Frank-Garcia, Ana; Royo, José Luis; Moreno, Fermin; Vilas, Raquel Huerto; Baquero, Miquel; Diez-Fairen, Monica; Lage, Carmen; García-Madrona, Sebastian; Garcia-Gonzalez, Pablo; Alarcón-Martín, Emilio; Valero, Sergi; Sotolongo-Grau, Oscar; Ullgren, Abbe; Naj, Adam C.; Lemstra, Afina W.; Benaque, Alba; Perez-Cordon, Alba; Benussi, Alberto; Rabano, Alberto (Journal article; Peer reviewed, 2021)

  Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical ...

• Effects of nutritional interventions in individuals with chronic obstructive lung disease: A systematic review of randomized controlled trials 

  Furulund, Einar; Bemanian, Mitra; Berggren, Nina Andrea; Madebo, Tesfaye; Rivedal, Sara Hydle; Lid, Torgeir Gilje; Fadnes, Lars T. (Journal article; Peer reviewed, 2021)

  Background: The role of nutrition and dietary patterns has been widely investigated in cancer, cardiovascular disease, and diabetes, but there are limited data on nutritional impact on COPD. This systematic review ...

• Increased circulating IL-18 levels in severe mental disorders indicate systemic inflammasome activation 

  Szabo, Attila; O'Connell, Kevin Sean; Ueland, Thor; Sheikh, Mashhood Ahmed; Agartz, Ingrid; Andreou, Dimitrios; Aukrust, Pål; Boye, Birgitte; Bøen, Erlend; Drange, Ole Kristian; Elvsåshagen, Torbjørn; Engh, John; Hope, Sigrun; Høegh, Margrethe Collier; Joa, Inge; Johnsen, Erik; Kroken, Rune Andreas; Lagerberg, Trine Vik; Lekva, Tove; Malt, Ulrik Fredrik; Melle, Ingrid; Morken, Gunnar; Nærland, Terje; Steen, Vidar Martin; Sørensen, Kjetil; Wedervang-Resell, Kirsten; Weibell, Melissa Anne Elin Authen; Westlye, Lars Tjelta; Steen, Nils Eiel; Andreassen, Ole; Djurovic, Srdjan (Journal article; Peer reviewed, 2022)

  Background Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental illnesses (SMI) that are part of a psychosis continuum, and dysregulated innate immune responses have been suggested to be involved in their ...

• Consultations and antibiotic treatment for urinary tract infections in Norwegian primary care 2006–2015, a registry-based study 

  Haugom, Lars; Ruths, Sabine; Emberland, Knut Erik; Eliassen, Knut Eirik Ringheim; Rørtveit, Guri; Wensaas, Knut-Arne (Journal article; Peer reviewed, 2021)

  Background Extensive use of antibiotics and the resulting emergence of antimicrobial resistance is a major health concern globally. In Norway, 82% of antibiotics is prescribed in primary care and one in four prescriptions ...

• Viewing the image? Ultrasound examination during abortion preparations, ethical challenges 

  Kjelsvik, Marianne; Sekse, Ragnhild Johanne Tveit; Aasen, Elin Margrethe; Gjengedal, Eva (Journal article; Peer reviewed, 2021)

  During preparation for early abortion in Norway, an ultrasound examination is usually performed to determine gestation and viability. This article aims to provide a deeper understanding of women’s and health care personnel’s ...

• Diagnostic performance of a SARS-CoV-2 rapid antigen test in a large, Norwegian cohort 

  Landaas, Elisabeth Toverud; Storm, Margrethe Larsdatter; Tollånes, Mette Christophersen; Barlinn, Regine; Kran, Anne-Marte Bakken; Bragstad, Karoline; Christensen, Andreas; Andreassen, Trude (Journal article; Peer reviewed, 2021)

  Background Rapid antigen tests (RATs) may be included in national strategies for handling the SARS-CoV-2 pandemic, as they provide test results rapidly, are easily performed outside laboratories, and enable immediate ...

• Artifacts on Magnetic Resonance Imaging from Electronic Identification Enablement in Silicone Gel Implants Are Not Negligible 

  Kurz, Kathinka Dæhli; Kallevåg, Øystein; Austrått, Kenneth; Styr, Bodil Margrethe; Leiknes, Jon Bjarne; Krøger, Pål (Journal article; Peer reviewed, 2021)

  Breast implants filled with silicone gel are used worldwide for cosmetic reasons, or breast reconstruction following risk-reducing or therapeutic mastectomy. The importance of identifiable implants is undeniable. A recent ...

• Prevalence, risk factors and association with delivery outcome of curable sexually transmitted infections among pregnant women in Southern Ethiopia 

  Zenebe, Mengistu Hailemariam; Mekonnen, Zeleke; Loha, Eskindir; Padalko, Elizaveta (Journal article; Peer reviewed, 2021)

  Introduction Curable sexually transmitted infections (STIs) such as infection with Chlamydia trachomatis (C. trachomatis), Neisseria gonorrhoeae (N. gonorrhoeae), and Trichomonas vaginalis (T. vaginalis) can lead to adverse ...

• The Effect of Intensive Implementation Support on Fidelity for Four Evidence‑Based Psychosis Treatments: A Cluster Randomized Trial 

  Ruud, Torleif; Drake, Robert E.; Saltyte Benth, Jurate; Drivenes, Karin; Hartveit, Miriam; Heiervang, Kristin Sverdvik; Høifødt, Tordis Sørensen; Haaland, Vegard Øksendal; Joa, Inge; Johannessen, Jan Olav; Johansen, Karl Johan; Stensrud, Bjørn; Haugom, Espen Woldsengen; Clausen, Hanne Kristin; Biringer, Eva Aaker; Bond, Gary R. (Journal article; Peer reviewed, 2021)

  Purpose Service providers need effective strategies to implement evidence-based practices (EBPs) with high fidelity. This study aimed to evaluate an intensive implementation support strategy to increase fidelity to EBP ...

• XAB2 promotes Ku eviction from single-ended DNA double-strand breaks independently of the ATM kinase 

  Sharma, Abhishek; Erasimus, Hélène; Pinto, Lia; Caron, Marie-Christine; Gopaul, Diyavarshini; Peterlini, Thibault; Neumann, Katrin; Nazarov, Petr V.; Fritah, Sabrina; Klink, Barbara; Herold-Mende, Christel C.; Niclou, Simone Pierrette; Pasero, Philippe; Calsou, Patrick; Masson, Jean-Yves; Britton, Sébastien; Van Dyck, Eric (Journal article; Peer reviewed, 2021)

  Replication-associated single-ended DNA double-strand breaks (seDSBs) are repaired predominantly through RAD51-mediated homologous recombination (HR). Removal of the non-homologous end-joining (NHEJ) factor Ku from resected ...

• Inhibition of the Human Hsc70 System by Small Ligands as a Potential Anticancer Approach 

  Dublang, Leire; Underhaug, Jarl; Flydal, Marte Innselset; Velasco-Carneros, Lorea; Maréchal, Jean-Didier; Moro, Fernando; Boyano, Maria Dolores; Martinez, Aurora; Muga, Arturo (Journal article; Peer reviewed, 2021)

  Heat shock protein (Hsp) synthesis is upregulated in a wide range of cancers to provide the appropriate environment for tumor progression. The Hsp110 and Hsp70 families have been associated to cancer cell survival and ...

• Abnormal neonatal sodium handling in skin precedes hypertension in the SAME rat 

  Mullins, Linda; Ivy, Jessica; Ward, Mairi; Tenstad, Olav; Wiig, Helge; Kitada, Kento; Manning, Jon; Rakova, Natalia; Müller, Dominik; Mullins, John (Journal article; Peer reviewed, 2021)

  We discovered high Na+ and water content in the skin of newborn Sprague–Dawley rats, which reduced ~ 2.5-fold by 7 days of age, indicating rapid changes in extracellular volume (ECV). Equivalent changes in ECV post birth ...

• Glioblastomas with primitive neuronal component harbor a distinct methylation and copy‑number profle with inactivation of TP53, PTEN, and RB1 

  Suwala, Abigail K.; Stichel, Damian; Schrimpf, Daniel; Maas, Sybren L. N.; Sill, Martin; Dohmen, Hildegard; Banan, Rouzbeh; Reinhardt, Annekathrin; Sievers, Philipp; Hinz, Felix; Blattner-Johnson, Mirjam; Hartmann, Christian; Schweizer, Leonille; Boldt, Henning B.; Kristensen, Bjarne Winther; Schittenhelm, Jens; Wood, Matthew D.; Chotar, Guillaume; Bjerkvig, Rolf; Das, Anirban; Tabori, Uri; Hasselblatt, Martin; Korshunov, Andrey; Abdullaev, Zied; Quezado, Martha; Aldape, Kenneth; Harter, Patrick N.; Snuderl, Matija; Hench, Jürgen; Frank, Stephan; Acker, Till; Brandner, Sebastian; Winkler, Frank; Wesseling, Pieter; Pfister, Stefan M.; Reuss, David E.; Wick, Wolfgang; von Deimling, Andreas; Jones, David T. W.; Sahm, Felix (Journal article; Peer reviewed, 2021)

  Glioblastoma IDH-wildtype presents with a wide histological spectrum. Some features are so distinctive that they are considered as separate histological variants or patterns for the purpose of classification. However, these ...

• Clinical responses following inspiratory muscle training in exercise-induced laryngeal obstruction 

  Sandnes, Astrid; Andersen, Tiina Maarit; Clemm, Hege Synnøve Havstad; Hilland, Magnus; Heimdal, John-Helge; Halvorsen, Thomas; Røksund, Ola Drange; Vollsæter, Maria (Journal article; Peer reviewed, 2021)

  Purpose Exercise-induced laryngeal obstruction (EILO) is relatively common in young people. Treatment rests on poor evidence; however, inspiratory muscle training (IMT) has been proposed a promising strategy. We aimed to ...

• Patient specific factors predicting adherence and treatment effect of oral appliance therapy in obstructive sleep apnea 

  Gjerde, Kjersti (Doctoral thesis, 2022-02-04)

  The overall objective of this thesis was to generate new knowledge about treatment with mandibular advancement devices (MAD). MAD. Adherence and MAD treatment effects were measured in patients suffering from obstructive ...

• Temporal variations in the nutrient content of Norwegian farmed Atlantic salmon (Salmo salar), 2005–2020 

  Reksten, Amalie Moxness; Ho, Quang Tri; Nøstbakken, Ole Jakob; Markhus, Maria Wik; Kjellevold, Marian; Bøkevoll, Annbjørg; Hannisdal, Rita; Frøyland, Livar; Madsen, Lise; Dahl, Lisbeth (Journal article; Peer reviewed, 2022)

  The changes in the feed of farmed Atlantic salmon (Salmo salar) towards a more plant-based diet affect the nutritional value of the fillets. By compiling the contents of a range of nutrients in 1108 samples of Norwegian ...

• The balance between NAD+ biosynthesis and consumption in ageing 

  Strømland, Øyvind; Diab, Joseph; Ferrario, Eugenio; Sverkeli, Lars Jansen; Ziegler, Mathias (Journal article; Peer reviewed, 2021)

  Nicotinamide adenine dinucleotide (NAD+) is a vital coenzyme in redox reactions. NAD+ is also important in cellular signalling as it is consumed by PARPs, SARM1, sirtuins and CD38. Cellular NAD+ levels regulate several ...

• Proteoglycans contribute to the functional integrity of the glomerular endothelial cell surface layer and are regulated in diabetic kidney disease 

  Khramova, Alina; Boi, Roberto; Fridén, Vincent; Granqvist, Anna Björnson; Nilsson, Ulf; Tenstad, Olav; Oveland, Eystein; Haraldsson, Börje; Ebefors, Kerstin; Nyström, Jenny (Journal article; Peer reviewed, 2021)

  All capillary endothelia, including those of the glomeruli, have a luminal cell surface layer (ESL) consisting of glycoproteins, glycolipids, proteoglycans (PGs) and glycosaminoglycans. Previous results have demonstrated ...

• CSF neurofilament light chain predicts 10-year clinical and radiologic worsening in multiple sclerosis 

  Bhan, Alok; Jacobsen, Cecilie; Dalen, Ingvild; Bergsland, Niels; Zivadinov, Robert; Alves, Guido Werner; Myhr, Kjell-Morten; Farbu, Elisabeth (Journal article; Peer reviewed, 2021)

  Background Neurofilament light chain (NfL) is an attractive biomarker of disease activity and progression in MS, but there is a lack in long-term prognostic data. Objective To test the long-term clinical and radiological ...

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