Faculty of Medicine
Recent Submissions
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Fecal bacteria and short-chain fatty acids in irritable bowel syndrome: relations to subtype
(Journal article; Peer reviewed, 2024)Background: The relationship between gut microbiota and irritable bowel syndrome (IBS) subtype is unclear. We aimed to explore whether differences in fecal bacteria composition and short-chain fatty acid (SCFA) levels were ... -
Lower Limits for Reporting High-Sensitivity Cardiac Troponin Assays and Impact of Analytical Performance on Patient Misclassification
(Journal article; Peer reviewed, 2024)Background: Cardiac troponin measurements are indispensable for the diagnosis of myocardial infarction and provide useful information for long-term risk prediction of cardiovascular disease. Accelerated diagnostic pathways ... -
Repeat expansions in AR, ATXN1, ATXN2 and HTT in Norwegian patients diagnosed with amyotrophic lateral sclerosis
(Journal article; Peer reviewed, 2024)Genetic repeat expansions cause neuronal degeneration in amyotrophic lateral sclerosis as well as other neurodegenerative disorders such as spinocerebellar ataxia, Huntington’s disease and Kennedy’s disease. Repeat expansions ... -
Meeting Summary of The NYO3 5th NO-Age/AD Meeting and the 1st Norway-UK Joint Meeting on Aging and Dementia: Recent Progress on the Mechanisms and Interventional Strategies
(Journal article; Peer reviewed, 2024)Unhealthy aging poses a global challenge with profound healthcare and socioeconomic implications. Slowing down the aging process offers a promising approach to reduce the burden of a number of age-related diseases, such ... -
Plasma brain-derived tau is an amyloid-associated neurodegeneration biomarker in Alzheimer’s disease
(Journal article; Peer reviewed, 2024)Staging amyloid-beta (Aβ) pathophysiology according to the intensity of neurodegeneration could identify individuals at risk for cognitive decline in Alzheimer’s disease (AD). In blood, phosphorylated tau (p-tau) associates ... -
Preoperative fatty infiltration of paraspinal muscles assessed by MRI is associated with less improvement of leg pain 2 years after surgery for lumbar spinal stenosis
(Journal article; Peer reviewed, 2024)Abstract Purpose Fatty infiltration (FI) of the paraspinal muscles may associate with pain and surgical complications in patients with lumbar spinal stenosis (LSS). We evaluated the prognostic influence of MRI-assessed ... -
Implementing Clinical Guidelines for the Treatment of Psychosis: The Frontline Leaders’ Point of View. A Qualitative Study
(Journal article; Peer reviewed, 2024)Background: Despite the large amount of leadership and implementation theories and recommendations, healthcare services continue to struggle with efficiently incorporating new knowledge. The questioning of conventional ... -
Couple Relationship Problems in General Practice : A multiple methods study of prevalence and experiences from discussions of couple relationship problems in GP consultations
(Doctoral thesis, 2024-10-11)Bakgrunn: Samlivskvalitet er assosiert med fysisk og psykisk helse samt livslengde. Det mangler kunnskap om hvilken rolle samtaler om parforhold har og bør ha i allmennpraksis. Mål: Å kartlegge omfanget av samlivstemaer ... -
The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC derived Cortical Organoid of Alpers' Disease
(Journal article; Peer reviewed, 2024)Alpers' syndrome is an early-onset neurodegenerative disorder usually caused by biallelic pathogenic variants in the gene encoding the catalytic subunit of polymerase-gamma (POLG), which is essential for mitochondrial DNA ... -
Population-based tuberculosis screening : Prevalence, incidence and cluster analysis in southern Ethiopia
(Doctoral thesis, 2024-10-25)Bakgrunn: Detyyt har vært mange internasjonale initiativer for å stoppe tuberkuloseepidemien, og både tuberkulosedødelighet og insidensrater faller globalt. Likevel er sykdommen en betydelig utfordring for befolkninger og ... -
Maternal mortality in Sidama Region, southern Ethiopia : Results from surveys on mortality and the coverage of available interventions
(Doctoral thesis, 2024-10-22)Summary Background: Etiopia er et lavinntektsland hvor mødredødsfall er et stort samfunnshelse problem. I 2020 døde 10,000 mødre i Etiopia og dette representerte 3.6% av den globale byrden. Etiopia mangler et register ... -
Structure-based design of 1-deoxy-D-xylulose 5-phosphate reductoisomerase ligands
(Doctoral thesis, 2024-08-29)The widespread use of antibiotics has undoubtedly saved countless lives over the last century. However, their indiscriminate use has contributed to the emergence of antimicrobial resistance (AMR), posing a significant ... -
A scoping review on the associations between early childhood caries and sustainable cities and communities using the sustainable development goal 11 framework
(Journal article; Peer reviewed, 2024)Background: Early childhood caries (ECC) is a multifactorial disease in which environmental factors could play a role. The purpose of this scoping review was to map the published literature that assessed the association ... -
Association between early childhood caries and parental education and the link to the sustainable development goal 4: a scoping review
(Journal article; Peer reviewed, 2024-05-02)Background: The goal of the United Nations Sustainable Development Goal (SDG) 4 is to ensure inclusive and equitable quality education and promote lifelong learning opportunities for all. The aim of this scoping review was ... -
Early childhood caries, climate change and the sustainable development goal 13: a scoping review
(Journal article; Peer reviewed, 2024-05-03)Background: Sustainable development goal 13 centres on calls for urgent action to combat climate change and its impacts. The aim of this scoping review was to map the published literature for existing evidence on the ... -
Health complaints before and at one and five years after removal of dental amalgam restorations - data from a prospective cohort study in Norway
(Journal article; Peer reviewed, 2024)Objective: Health complaints attributed to dental amalgam fillings comprise both intraoral and general health complaints. There are data suggesting that patients with medically unexplained physical symptoms (MUPS) attributed ... -
Previous cartilage surgery is associated with inferior patient-reported outcomes after knee arthroplasty
(Journal article; Peer reviewed, 2024)Purpose: The hypothesis of the present study assumed that a history of focal cartilage lesions would not affect Knee Injury and Osteoarthritis Outcome scores (KOOSs) following knee arthroplasty compared to a matched national ... -
Biotin: a scoping review for Nordic Nutrition Recommendations 2023
(Journal article; Peer reviewed, 2024)Biotin is a water-soluble B-vitamin with key roles in metabolism and are found in most foods at low concentrations. Symptomatic biotin deficiency is rare, and few studies have investigated biotin requirements in relation ... -
Extracellular Vesicles as Next-Generation Diagnostics and Advanced Therapy Medicinal Products
(Journal article; Peer reviewed, 2024-06-13)Extracellular vesicles (EVs) hold great promise for clinical application as new diagnostic and therapeutic modalities. This paper describes major GMP-based upstream and downstream manufacturing processes for EV large-scale ... -
Feasibility of a physical activity intervention for children and adolescents with anxiety and depression
(Journal article; Peer reviewed, 2024-03-05)Background: Physical activity is identified as a key modifiable factor towards good short- and long-term mental health and has shown positive effects on anxiety and depression in children and adolescents. However, physical ...
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