• Strong tuberculin response after BCG vaccination is associated with low multiple sclerosis risk: a population-based cohort study 

  Nakken, Ola; Holmøy, Trygve; Stigum, Hein; Myhr, Kjell-Morten; Dahl, Jesper; Heldal, Einar; Meyer, Haakon Eduard (Journal article; Peer reviewed, 2022)

  Background: Multiple sclerosis (MS) is characterized by inflammatory lesions in the central nervous system involving pro-inflammatory T-cells. Immune dysregulation is well described in prevalent disease, but it is not known ...

• Ureteroscopy for stone disease in the paediatric population: lessons learned and outcomes in a Nordic setting 

  Jones, Charles Patrick Warburton; Æsøy, Mathias S.; Gjengstø, Peder; Beisland, Christian; Ulvik, Øyvind (Journal article; Peer reviewed, 2022)

  Introduction: Paediatric stone disease is rare in the Nordic communities. Still, the condition can require surgical intervention in the form of ureteroscopy (URS). Here, we report outcomes achieved at a regional (tertiary) ...

• A novel age-related gene expression signature associates with proliferation and disease progression in breast cancer 

  Ingebriktsen, Lise Martine; Finne, Kenneth; Akslen, Lars Andreas; Wik, Elisabeth (Journal article; Peer reviewed, 2022)

  Background and objective Breast cancer (BC) diagnosed at ages <40 years presents with more aggressive tumour phenotypes and poorer clinical outcome compared to older BC patients. Here, we explored transcriptional BC ...

• Quantitative pupillometry in comatose out-of-hospital cardiac arrest patients: A post-hoc analysis of the TTH48 trial 

  Paramanathan, Sansuthan; Grejs, Anders Morten; Søreide, Eldar; Duez, Christophe Henri Valdemar; Jeppesen, Anni Nørgaard; Reinertsen, Åse Johanne; Strand, Kristian; Kirkegaard, Hans (Journal article; Peer reviewed, 2022)

  Background: Quantitative pupillometry is an objective method to examine pupil reaction and subsequently grade the response on a neurological pupil index (NPi) scale from 0 to 5. The aim of the present sub-study was to ...

• Cancer and stroke: commonly encountered by clinicians, but little evidence to guide clinical approach 

  Woock, Malin; Martinez-Majander, Nicolas; Seiffge, David J.; Selvik, Henriette Aurora; Nordanstig, Annika; Redfors, Petra; Lindgren, Erik; Sanchez van Kammen, Mayte; Rentzos, Alexandros; Coutinho, Jonathan M.; Doyle, Karen; Næss, Halvor; Putaala, Jukka; Jood, Katarina; Tatlisumak, Turgut (Journal article; Peer reviewed, 2022)

  The association between stroke and cancer is well-established. Because of an aging population and longer survival rates, the frequency of synchronous stroke and cancer will become even more common. Different pathophysiologic ...

• The Romberg sign, unilateral vestibulopathy, cerebrovascular risk factors, and long-term mortality in dizzy patients 

  Berge, Jan Erik; Goplen, Frederik Kragerud; Aarstad, Hans Jørgen; Storhaug, Tobias Andre; Nordahl, Stein Helge Glad (Journal article; Peer reviewed, 2022)

  Objectives: Describe the relationship between unsteadiness, canal paresis, cerebrovascular risk factors, and long-term mortality in patients examined for dizziness of suspected vestibular origin. Study design: Observational ...

• Epidemiology of abdominal trauma: An age- and sex-adjusted incidence analysis with mortality patterns 

  Larsen, Johannes Wiik; Søreide, Kjetil; Søreide, Jon Arne; Tjosevik, Kjell E; Kvaløy, Jan Terje; Thorsen, Kenneth (Journal article; Peer reviewed, 2022)

  Purpose Abdominal injuries may occur in up to one-third of all patients who suffer severe trauma, but little is known about epidemiological trends and characteristics in a Northern European setting. This study investigated ...

• Clinical outcome measures in dementia with Lewy bodies trials: critique and recommendations 

  Rodriguez-Porcel, Federico; Wyman-Chick, Kathryn A.; Abdelnour Ruiz, Carla; Toledo, Jon B.; Ferreira, Daniel; Urwyler, Prabitha; Weil, Rimona S.; Kane, Joseph; Pilotto, Andrea; Rongve, Arvid; Boeve, Bradley; Taylor, John-Paul; McKeith, Ian; Aarsland, Dag; Lewis, Simon J. G. (Journal article; Peer reviewed, 2022)

  The selection of appropriate outcome measures is fundamental to the design of any successful clinical trial. Although dementia with Lewy bodies (DLB) is one of the most common neurodegenerative conditions, assessment of ...

• Safety of breast feeding during rituximab treatment in multiple sclerosis 

  Rød, Brit Ellen; Torkildsen, Øivind; Myhr, Kjell-Morten; Bø, Lars; Wergeland, Stig (Journal article; Peer reviewed, 2022)

  Background There are limited data on the safety of breast feeding during rituximab therapy. Our objective is to determine exposure from breast feeding and biological effects of rituximab in breastfed infants. Methods ...

• Multimodal multi-center analysis of electroconvulsive therapy effects in depression: Brainwide gray matter increase without functional changes 

  van de Mortel, L.A.; Bruin, W.B.; Thomas, R.M.; Abbott, C.; Argyelan, M.; van Eijndhoven, P.; Mulders, P.; Narr, K.L.; Tendolkar, I.; Verdijk, J.P.A.J.; van Waarde, J.A.; Bartsch, Hauke; Oltedal, Leif; van Wingen, G.A. (Journal article; Peer reviewed, 2022)

  Background: Electroconvulsive therapy (ECT) is an effective treatment for severe depression and induces gray matter (GM) increases in the brain. Small-scale studies suggest that ECT also leads to changes in brain functioning, ...

• Kidney biopsy diagnosis in childhood in the Norwegian Kidney Biopsy Registry and the long-term risk of kidney replacement therapy: a 25-year follow-up 

  Gjerstad, Ann Christin; Skrunes, Rannveig; Tøndel, Camilla; Åsberg, Anders; Leh, Sabine; Klingenberg, Claus Andreas; Døllner, Henrik; Hammarström, Clara Louise; Bjerre, Anna Kristina (Journal article; Peer reviewed, 2022)

  Background: There is scarce information on biopsy-verified kidney disease in childhood and its progression to chronic kidney disease stage 5 (CKD 5). This study aims to review biopsy findings in children, and to investigate ...

• Trauma team training in Norwegian hospitals: an observational study 

  Bredin, Ida Celine; Gaup, Hedi Marina Joks; Brattebø, Guttorm; Wisborg, Torben (Journal article; Peer reviewed, 2022)

  Background Traumatic injuries are a leading cause of deaths in Norway, especially among younger males. Trauma-related mortality can be reduced by structural measures, such as organization of a trauma system. Many hospitals ...

• More Than Fish—Framing Aquatic Animals within Sustainable Food Systems 

  Pounds, Alexandra; Kaminski, Alexander M.; Budhathoki, Mausam; Gudbrandsen, Oddrun Anita; Kok, Björn; Horn, Stephanie; Malcorps, Wesley; Mamun, Abdullah-Al; McGoohan, Amy; Newton, Richard; Ozretich, Reed; Little, David C. (Journal article; Peer reviewed, 2022)

  Aquatic animals are diverse in terms of species, but also in terms of production systems, the people involved, and the benefits achieved. In this concept piece, we draw on literature to outline how the diversity of aquatic ...

• Agreement of clinical assessment of burn size and burn depth between referring hospitals and burn centres: A systematic review 

  Brekke, Ragnvald Ljones; Almeland, Stian Kreken; Hufthammer, Karl Ove; Hansson, Emma (Journal article; Peer reviewed, 2022)

  Background: The quality of burn care is highly dependent on the initial assessment and care. The aim of this systematic review was to investigate the agreement of clinical assessment of burn depth and %TBSA between the ...

• Impact of previous disease-modifying treatment on safety and efficacy in patients with MS treated with AHSCT 

  Stokke, Silje Agnethe; Burman, Joachim; Lehmann, Anne Kristine; Tolf, Andreas; Zjukovskaja, Christina; Melve, Guro Kristin; Bø, Lars; Torkildsen, Øivind (Journal article; Peer reviewed, 2022)

  Background Autologous haematopoietic stem cell transplantation (AHSCT) is a highly effective treatment for multiple sclerosis (MS). The impact of previous long-lasting disease-modifying treatments (DMT) for safety and ...

• Is intracranial volume a risk factor for IDH-mutant low-grade glioma? A case-control study 

  Sagberg, Lisa Millgård; Fyllingen, Even Hovig; Hansen, Tor Ivar; Strand, Per Sveino; Håvik, Aril Løge; Sundstrøm, Terje; Corell, Alba; Jakola, Asgeir Store; Salvesen, Øyvind; Solheim, Ole (Journal article; Peer reviewed, 2022)

  Purpose Risk of cancer has been associated with body or organ size in several studies. We sought to investigate the relationship between intracranial volume (ICV) (as a proxy for lifetime maximum brain size) and risk of ...

• Preoperative pelvic MRI and 2-[18F]FDG PET/CT for lymph node staging and prognostication in endometrial cancer—time to revisit current imaging guidelines? 

  Fasmer, Kristine Eldevik; Gulati, Ankush; Dybvik, Julie Andrea; Wagner-Larsen, Kari Strøno; Lura, Njål Gjærde; Salvesen, Øyvind; Forsse, David Erik; Trovik, Jone; Pijnenborg, Johanna M. A.; Krakstad, Camilla; Haldorsen, Ingfrid S. (Journal article; Peer reviewed, 2022)

  Objective This study presents the diagnostic performance of four different preoperative imaging workups (IWs) for prediction of lymph node metastases (LNMs) in endometrial cancer (EC): pelvic MRI alone (IW1), MRI and ...

• Medication Prescription, Common Side-effects, and Nutritional Status are Associated in Patients With Chronic Kidney Disease 

  Dahl, Helene; Sandblost, Silje Regine Thue; Welland, Natasha Lervaag; Sandnes, Kristina; Sekse, Ingegjerd; Sæle, Kristin; Marti, Hans Peter; Holst, Lone; Dierkes, Jutta (Journal article; Peer reviewed, 2022)

  Objective Chronic kidney disease (CKD) is associated with metabolic, nutritional, and extra-renal changes, as well as a high rate of comorbidities, which necessitates the prescription of numerous medications. Patients ...

• Influence of circulatory shock at hospital admission on outcome after out-of-hospital cardiac arrest 

  Düring, Joachim; Annborn, Martin; Dankiewicz, Josef; Dupont, Allison; Forsberg, Sune; Friberg, Hans; Kern, Karl B.; May, Teresa L.; McPherson, John; Patel, Nainesh; Seder, David B.; Stammet, Pascal; Sunde, Kjetil; Søreide, Eldar; Ullén, Susann; Nielsen, Niklas (Journal article; Peer reviewed, 2022)

  Hypotension after cardiac arrest could aggravate prolonged hypoxic ischemic encephalopathy. The association of circulatory shock at hospital admission with outcome after cardiac arrest has not been well studied. The objective ...

• Vasoactive and/or inotropic drugs in initial resuscitation of burn injuries: A systematic review 

  Knappskog, Kristine; Andersen, Nina Gjerde; Guttormsen, Anne Berit; Onarheim, Henning; Almeland, Stian Kreken; Beitland, Sigrid (Journal article; Peer reviewed, 2022)

  Background According to current guidelines, initial burn resuscitation should be performed with fluids alone. The aims of the study were to review the frequency of use of vasoactive and/or inotropic drugs in initial burn ...

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