• Studies of gene expression in the Parkinson’s disease brain 

  Dick, Fiona (Doctoral thesis, 2021-10-01)

  Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder, affecting ~1.8% of the population above 65 years. A combination of genetic and environmental factors contributes to the risk of PD, but the ...

• Preference-based instrumental variables in health research rely on important and underreported assumptions: a systematic review 

  Widding-Havneraas, Tarjei; Chaulagain, Ashmita; Lyhmann, Ingvild; Zachrisson, Henrik Daae; Elwert, Felix; Markussen, Simen; McDaid, David; Mykletun, Arnstein (Journal article; Peer reviewed, 2021)

  Objective: Preference-based instrumental variables (PP IV) designs can identify causal effects when patients receive treatment due to variation in providers’ treatment preference. We offer a systematic review and methodological ...

• Gastric dysmotility and visceral hypersensitivity – an ultrasound approach to functional GI disorders and diabetic gastroparesis 

  Steinsvik, Elisabeth Kjelsvik (Doctoral thesis, 2021-09-24)

  Background: Functional dyspepsia (FD), irritable bowel syndrome (IBS) and diabetic gastroparesis (DG) are conditions with overlapping symptoms and motility characteristics. The objective of this dissertation was to investigate ...

• The anatomic centers of the femoral and tibial insertions of the anterior cruciate ligament: a systematic review of imaging and cadaveric studies reporting normal center locations 

  Parkar, Anagha P; Adriaensen, Miraude E.A.M.P.; Vindfeld, Søren; Solheim, Eirik (Journal article; Peer reviewed, 2016)

  Background: The anterior cruciate ligament (ACL) is regularly reconstructed if knee joint function is impaired. Anatomic graft tunnel placement, often assessed with varying measurement methods, in the femur and tibia is ...

• ISUOG Practice Guidelines (updated): use of Doppler velocimetry in obstetrics 

  Bhide, Amarnath; Acharya, Ganesh; Baschat, Ahmet Alexander; Bilardo, Caterina Maddalena; Brezinka, Christoph; Cafici, Daniel; Ebbing, Cathrine; Hernandez-Andrade, Edgar A.; Kalache, Karim; Kingdom, John; Kiserud, Torvid; Surendran, Sailesh Kumar; Lee, Wesley; Lees, Christoph; Leung, Kwok Yin; Malinger, Gustavo; Mari, Giancarlo; Prefumo, Federico; Sepulveda, Waldo; Trudinger, Brian (Journal article; Peer reviewed, 2021)

• Overexpression of mir-20a-5p in tumor epithelium is an independent negative prognostic indicator in prostate cancer—a multi-institutional study 

  Stoen, Maria J.; Andersen, Sigve; Rakaee, Mehrdad; Pedersen, Mona I.; Ingebriktsen, Lise M.; Dønnem, Tom; Lombardi, Ana P. G.; Kilvaer, Thomas K.; Rasmussen Busund, Lill-Tove; Richardsen, Elin (Journal article; Peer reviewed, 2021)

  Objective: assessing the prognostic role of miR-20a-5p, in terms of clinical outcome, in a large multi-institutional cohort study. Methods: Tissue microarrays from 535 patients’ prostatectomy specimens were constructed. ...

• Long-term effects of fecal microbiota transplantation (FMT) in patients with irritable bowel syndrome 

  El-Salhy, Magdy; Bråthen Kristoffersen, Anja; Valeur, Jørgen; Casén, Christina; Hatlebakk, Jan Gunnar; Gilja, Odd Helge; Hausken, Trygve (Journal article; Peer reviewed, 2021)

  Background We recently found fecal microbiota transplantation (FMT) in irritable bowel syndrome (IBS) patients to be an effective and safe treatment after 3 months. The present follow-up study investigated the efficacy ...

• Gene expression alterations in salivary gland epithelia of Sjögren’s syndrome patients are associated with clinical and histopathological manifestations 

  Dela Cruz, Ariana; Kartha, Vinay; Tilston-Lunel, Andrew; Mi, Rongjuan; Reynolds, Taylor L.; Mingueneau, Michael; Monti, Stefano; Jensen, Janicke Liaaen; Skarstein, Kathrine; Varelas, Xaralabos; Kukuruzinska, Maria A. (Journal article; Peer reviewed, 2021)

  Sjögren’s syndrome (SS) is a complex autoimmune disease associated with lymphocytic infiltration and secretory dysfunction of salivary and lacrimal glands. Although the etiology of SS remains unclear, evidence suggests ...

• High expression of miR‑17‑5p in tumor epithelium is a predictor for poor prognosis for prostate cancer patients 

  Støen, Maria Jenvin; Andersen, Sigve; Rakaee, Mehrdad; Pedersen, Mona Irene; Ingebriktsen, Lise Martine; Bremnes, Roy M.; Dønnem, Tom; Lombardi, Ana Paola; Kilvær, Thomas Karsten; Rasmussen Busund, Lill-Tove; Richardsen, Elin (Journal article; Peer reviewed, 2021)

  MicroRNAs (miRs) are small non-coding RNA molecules, which are involved in the development of various malignancies, including prostate cancer (PCa). miR-17-5p is considered the most prominent member of the miR-17-92 cluster, ...

• On the Epidemiology, Diagnosis and Treatment of Upper Tract Urothelial Carcinoma 

  Almås, Bjarte (Doctoral thesis, 2021-09-17)

  Aims: The overall aim of this thesis was to increase our knowledge about the epidemiology, diagnostics and treatment of upper tract urothelial carcinoma (UTUC). For paper 1, the aim was to obtain contemporary knowledge ...

• Waiting time for hip fracture surgery: hospital variation, causes, and effects on postoperative mortality. Data on 37,708 operations reported to the Norwegian Hip fracture Register from 2014 to 2018 

  Kjærvik, Cato; Gjertsen, Jan-Erik; Engesæter, Lars B.; Stensland, Eva; Dybvik, Eva Hansen; Søreide, Odd (Journal article, 2021)

  Aims: This study aimed to describe preoperative waiting times for surgery in hip fracture patients in Norway, and analyze factors affecting waiting time and potential negative consequences of prolonged waiting time. Methods: ...

• Endothelial cells in emerging viral infections 

  Hol, Johanna; Haraldsen, Guttorm; Falk, Knut; Edelmann, Reidunn Jetne (Journal article; Peer reviewed, 2021-02-24)

  There are several reasons to consider the role of endothelial cells in COVID-19 and other emerging viral infections. First, severe cases of COVID-19 show a common breakdown of central vascular functions. Second, SARS-CoV-2 ...

• The role of imaging in anterior cruciate ligament reconstruction 

  Parkar, Anagha P. (Doctoral thesis, 2021-08-27)

  The thesis is based on four articles examining the role of imaging after surgical reconstruction of the anterior cruciate ligament of the knee. Post-operative imaging is commonly performed to validate ACL graft tunnel ...

• Lower conversion rate with robotic assisted rectal resections compared with conventional laparoscopy; a national cohort study 

  Myrseth, Elisabeth; Nymo, Linn Såve; Gjessing, Petter Fosse; Kørner, Hartwig; Kvaløy, Jan Terje; Norderval, Stig (Journal article; Peer reviewed, 2021)

  Background Conversion from laparoscopic to open access colorectal surgery is associated with a poorer postoperative outcome. The aim of this study was to assess conversion rates and outcomes after standard laparoscopic ...

• Early constipation predicts faster dementia onset in Parkinson's disease 

  Camacho, Marta; Macleod, Angus D.; Grødem, Jodi Maple; Evans, Jonathan R.; Breen, David P.; Cummins, G; Wijeyekoon, Ruwani; Greenland, Julia; Alves, Guido Werner; Tysnes, Ole-Bjørn; Lawson, Rachel A.; Barker, Roger A.; Williams-Gray, Caroline H. (Journal article; Peer reviewed, 2021)

  Constipation is a common but not a universal feature in early PD, suggesting that gut involvement is heterogeneous and may be part of a distinct PD subtype with prognostic implications. We analysed data from the Parkinson’s ...

• Cost utility analysis of intramedullary nailing and skeletal traction treatment for patients with femoral shaft fractures in Malawi 

  Chokotho, Linda; Donnelley, Claire A; Young, Sven; Lau, Brian C.; Wu, Hao-Hua; Mkandawire, Nyengo; Gjertsen, Jan-Erik; Hallan, Geir; Agarwal-Harding, Kiran J; Shearer, David (Journal article; Peer reviewed, 2021)

  Background and purpose — In Malawi, both skeletal traction (ST) and intramedullary nailing (IMN) are used in the treatment of femoral shaft fractures, ST being the mainstay treatment. Previous studies have found that IMN ...

• Association of GBA Genotype With Motor and Functional Decline in Patients With Newly Diagnosed Parkinson Disease 

  Grødem, Jodi Maple; Dalen, Ingvild; Tysnes, Ole-Bjørn; Macleod, Angus D.; Forsgren, Lars; Counsell, Carl E.; Alves, Guido Werner (Journal article; Peer reviewed, 2021)

  Objective To establish the significance of glucocerebrosidase gene (GBA) carrier status on motor impairment in a large cohort of patients with incident Parkinson disease (PD). Methods Three European population-based ...

• Zilucoplan: An Investigational Complement C5 Inhibitor for the Treatment of Acetylcholine Receptor Autoantibody–Positive Generalized Myasthenia Gravis 

  Howard, James F.; Vissing, John; Gilhus, Nils Erik; Leite, Maria Isabel; Utsugisawa, Kimiaki; Duda, Petra W.; Farzaneh-Far, Ramin; Murai, Hiroyuki; Wiendl, Heinz (Journal article; Peer reviewed, 2021)

  Generalized myasthenia gravis (gMG) is an autoimmune disorder in which pathogenic autoantibodies damage the neuromuscular junction, causing disabling or life-threatening muscle weakness. Most treatments nonspecifically ...

• Development and clinical implementation of a structured, simulation-based training programme in laparoscopic appendectomy: Description, validation and evaluation 

  Skjold-Ødegaard, Benedicte; Ersdal, Hege Langli; Assmus, Jörg; Nedrebø, Bjørn Steinar Olden; Sjo, Ole; Søreide, Kjetil (Journal article; Peer reviewed, 2021)

  Background: Laparoscopic appendectomy is a common procedure in general surgery but is likely underused in structured and real-life teaching. This study describes the development, validation and evaluation of implementing ...

• Genome-wide histone acetylation analysis reveals altered transcriptional regulation in the Parkinson’s disease brain 

  Toker, Lilah; Tran, Gia T.; Sundaresan, Janani; Tysnes, Ole-Bjørn; Alves, Guido; Haugarvoll, Kristoffer; Nido, Gonzalo S.; Dölle, Christian; Tzoulis, Charalampos (Journal article; Peer reviewed, 2021)

  Background: Parkinson’s disease (PD) is a complex, age-related neurodegenerative disorder of largely unknown etiology. PD is strongly associated with mitochondrial respiratory dysfunction, which can lead to epigenetic ...

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