• Characteristics, management and survival of ICU patients with coronavirus disease-19 in Norway, March-June 2020. A prospective observational study 

  Laake, Jon Henrik; Buanes, Eirik A.; Småstuen, Milada C.; Kvåle, Reidar; Olsen, Brita Fosser; Rustøen, Tone; Strand, Kristian; Sørensen, Vibecke; Hofsø, Kristin (Journal article; Peer reviewed, 2021)

  Background: Norwegian hospitals have operated within capacity during the COVID-19 pandemic. We present patient and management characteristics, and outcomes for the entire cohort of adult (>18 years) COVID-19 patients ...

• Digital Image Analysis of the Proliferation Markers Ki67 and Phosphohistone H3 in Gastroenteropancreatic Neuroendocrine Neoplasms: Accuracy of Grading Compared with Routine Manual Hot Spot Evaluation of the Ki67 Index 

  Lea, Dordi; Gudlaugsson, Einar G.; Skaland, Ivar; Lillesand, Melinda; Søreide, Kjetil; Søreide, Jon A. (Journal article; Peer reviewed, 2021)

  Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are rare epithelial neoplasms. Grading is based on mitotic activity or the percentage of Ki67-positive cells in a hot spot. Routine methods have poor intraobserver ...

• Long-Term Survival in 1,931 Patients With Dizziness: Disease- and Symptom-Specific Mortality 

  Berge, Jan Erik; Nordahl, Stein Helge Glad; Aarstad, Hans Jørgen; Goplen, Frederik Kragerud (Journal article; Peer reviewed, 2021)

  Objective: To evaluate mortality among patients referred for suspected vestibular disorder and to examine whether specific symptoms or disorders predict long-term survival among patients with dizziness or vertigo. Study ...

• Ultrasound imaging for assessing functions of the GI tract 

  Steinsvik, Elisabeth Kjelsvik; Hatlebakk, Jan Gunnar; Hausken, Trygve; Nylund, Kim; Gilja, Odd Helge (Journal article; Peer reviewed, 2021)

  Objective: In the following review we outline how ultrasound can be used to measure physiological processes in the gastrointestinal tract. Approach: We have investigated the potential of ultrasound in assessing ...

• Dizziness and physical health are associated with pain in dizzy patients—A cross‐sectional study 

  Gustavsen, Ingvild Ølfarnes; Wilhelmsen, Kjersti; Goode, Adam P.; Nordahl, Stein Helge Glad; Goplen, Frederik Kragerud; Nilsen, Roy Miodini; Magnussen, Liv Heide (Journal article; Peer reviewed, 2021)

  Background and Purpose Associations between dizziness, health-related quality of life, and musculoskeletal pain have not been systematically explored in patients with vestibular disorders. Such knowledge may be important ...

• KRAS mutation analysis by droplet digital PCR of duodenal juice from patients with MODY8 and other pancreatic diseases 

  Choi, Man Hung; Tjora, Erling; Forthun, Rakel Brendsdal; Engjom, Trond; Ræder, Helge; Hovland, Randi; Molven, Anders (Journal article; Peer reviewed, 2021)

  Background Maturity-onset diabetes of the young type 8 (MODY8 or CEL-MODY) is an inherited pancreatic disease characterized by chronic inflammation of the pancreas and diabetes. It is not known whether MODY8 patients ...

• Management of cluster headache and other trigeminal autonomic cephalalgias in pregnancy and breastfeeding 

  Bjørk, Marte-Helene; Kristoffersen, Espen Saxhaug; Tronvik, Erling Andreas; Nordeng, Hedvig Marie Egeland (Journal article; Peer reviewed, 2021)

  Many clinicians lack experience in managing trigeminal autonomic cephalalgias (TACs) in pregnancy and lactation. In addition to cluster headache, TACs include hemicrania continua, paroxysmal hemicrania, and short-lasting ...

• Accounting for symptom heterogeneity can improve neuroimaging models of antidepressant response after electroconvulsive therapy 

  Wade, Benjamin; Hellemann, Gerhard S.; Espinoza, Randall; Woods, Roger P.; Joshi, Shantanu H.; Redlich, Ronny; Dannlowski, Udo; Jorgensen, Anders; Abbott, Christopher; Oltedal, Leif; Narr, Katherine L. (Journal article; Peer reviewed, 2021)

  Depression symptom heterogeneity limits the identifiability of treatment-response biomarkers. Whether improvement along dimensions of depressive symptoms relates to separable neural networks remains poorly understood. We ...

• Male to female ratios in autism spectrum disorders by age, intellectual disability and attention-deficit/hyperactivity disorder 

  Posserud, Maj-Britt; Skretting Solberg, Berit; Engeland, Anders; Haavik, Jan; Klungsøyr, Kari (Journal article; Peer reviewed, 2021)

  Objective To examine the gender distribution in ASD in adults compared with children and the impact of comorbid intellectual disability (ID) and attention-deficit/hyperactivity disorder (ADHD) on the male to female ratio ...

• Mental and somatic health in university students with type 1 diabetes: new results from DiaSHoT18, a cross sectional national health and well-being survey 

  Bratke, Heiko Holger Karl-Ernst; Sivertsen, Børge (Journal article; Peer reviewed, 2021)

  Objectives To explore mental and somatic health, quality of life, alcohol-related problems, sleep problems, and diabetes related distress in university students with type 1 diabetes (T1D), compared to students without ...

• Controlled Attenuation Parameter in Healthy Individuals Aged 8–70 Years 

  Mjelle, Anders Batman; Mulabecirovic, Anesa; Olafsdottir, Edda Jonina; Gilja, Odd Helge; Havre, Roald Flesland; Vesterhus, Mette Nåmdal (Journal article; Peer reviewed, 2021)

  Purpose Controlled attenuation parameter (CAP) is a non-invasive method to assess the presence of liver steatosis. It has been evaluated in children and adults, mainly in either the obese or in subjects with suspected ...

• Bag-in-the-lens intraocular lens in paediatric cataract surgery: intraoperative and postoperative outcomes 

  Boonstra, Nils-Erik; Haugen, Olav H. (Journal article; Peer reviewed, 2021)

  Purpose: To report intra- and postoperative surgical outcome using the bag-in-the-lens (BIL) technique in paediatric cataract surgery. Methods: In a retrospective case series, we studied the outcomes of children aged ...

• Genotype-phenotype correlations and novel molecular insights into the DHX30-associated neurodevelopmental disorders 

  Mannucci, Ilaria; Dang, Nghi D. P.; Huber, Hannes; Murry, Jaclyn B.; Abramson, Jeff; Althoff, Thorsten; Banka, Siddharth; Baynam, Gareth; Bearden, David; Beleza-Meireles, Ana; Benke, Paul J.; Berland, Siren; Bierhals, Tatjana; Bilan, Frédéric; Bindoff, Laurence A.; Braathen, Geir Julius; Busk, Øyvind; Chenbhanich, Jirat; Denecke, Jonas; Escobar, Luis F.; Estes, Caroline; Fleischer, Julie; Groepper, Daniel; Haaxma, Charlotte A.; Hempel, Maja; Holler-Managan, Yolanda; Houge, Gunnar Douzgos; Jackson, Adam; Kellogg, Laura; Keren, Boris; Kiraly-Borri, Catherine; Kraus, Cornelia; Kubisch, Christian; Le Guyader, Gwenaël; Ljungblad, Ulf Wike; Martinez-Agosto, Julian A.; Brenman, Leslie Manace; Might, Matthew; Miller, David T.; Minks, Kelly Q.; Moghaddam, Billur; Nava, Caroline; Nelson, Stanley F.; Parant, John M.; Prescott, Trine; Rajabi, Farrah; Randrianaivo, Hanitra; Reiter, Simone B. C. Frizell; Schuurs-Hoeijmakers, Janneke; Shieh, Perry B.; Slavotinek, Anne; Smithson, Sarah; Stegmann, Alexander P. A.; Tomczak, Kinga; Tveten, Kristian; Wang, Jun; Whitlock, Jordan H.; Zweier, Christiane; McWalter, Kirsty; Juusola, Jane; Quintero-Rivera, Fabiola; Fischer, Utz; Yeo, Nan Cher; Kreienkamp, Hans-Jürgen; Lessel, Davor (Journal article; Peer reviewed, 2021)

  Background: We aimed to define the clinical and variant spectrum and to provide novel molecular insights into the DHX30-associated neurodevelopmental disorder. Methods: Clinical and genetic data from affected individuals ...

• Is simulation-based team training performed by personnel in accordance with the INACSL Standards of Best Practice: SimulationSM?—a qualitative interview study 

  Finstad, Anne Strand; Ballangrud, Randi; Aase, Ingunn; Wisborg, Torben; Romundstad, Luis Georg; Bjørshol, Conrad Arnfinn (Journal article; Peer reviewed, 2021)

  Background: Anesthesia personnel was among the first to implement simulation and team training including non-technical skills (NTS) in the field of healthcare. Within anesthesia practice, NTS are critically important in ...

• An mri-based radiomic prognostic index predicts poor outcome and specific genetic alterations in endometrial cancer 

  Jacob, Havjin; Dybvik, Julie Andrea; Ytre-Hauge, Sigmund; Fasmer, Kristine E.; Høivik, Erling Andre; Trovik, Jone; Krakstad, Camilla; Haldorsen, Ingfrid S. (Journal article; Peer reviewed, 2021)

  Integrative tumor characterization linking radiomic profiles to corresponding gene expression profiles has the potential to identify specific genetic alterations based on non-invasive radiomic profiling in cancer. The aim ...

• The Risk of Benign Paroxysmal Positional Vertigo After Head Trauma 

  Andersson, Helene; Jablonski, Greg Eigner; Nordahl, Stein Helge Glad; Nordfalk, Karl; Helseth, Eirik; Martens, Camilla; Røysland, Kjetil; Goplen, Frederik Kragerud (Journal article; Peer reviewed, 2021)

  Objectives: Head trauma may cause dislodgement of otoconia and development of benign paroxysmal positional vertigo (BPPV). The risk of developing BPPV is expected to be highest shortly after the trauma, then decrease and ...

• Nicotinamide Riboside and Metformin Ameliorate Mitophagy Defect in Induced Pluripotent Stem Cell-Derived Astrocytes With POLG Mutations 

  Chen, Anbin; Kristiansen, Cecilie Katrin; Hong, Yu; Kianian, Atefeh; Fang, Evandro Fei; Sullivan, Gareth John; Wang, Jian; Li, X.; Bindoff, Laurence Albert; Liang, Xiao (Journal article; Peer reviewed, 2021)

  Mitophagy specifically recognizes and removes damaged or superfluous mitochondria to maintain mitochondrial homeostasis and proper neuronal function. Defective mitophagy and the resulting accumulation of damaged mitochondria ...

• K+ regulates relocation of Pellino-2 to the site of NLRP3 inflammasome activation in macrophages 

  Cristea, Ileana; Bruland, Ove; Rødahl, Eyvind; Bredrup, Cecilie (Journal article; Peer reviewed, 2021)

  Pellino proteins are E3 ubiquitin ligases involved in the innate immune system. Recently, Pellino-2 was reported to modulate the activation of the mouse Nlrp3 inflammasome. We examined the intracellular localization of ...

• Axl-inhibitor bemcentinib alleviates mitochondrial dysfunction in the unilateral ureter obstruction murine model 

  Hoel, August; Osman, Tarig; Hoel, Fredrik; Elsaid, Hassan Osman Alhassan; Chen, Tony; Landolt, Lea Zoe; Babickova, Janka; Tronstad, Karl Johan; Lorens, James B.; Gausdal, Gro; Marti, Hans-Peter; Furriol, Jessica (Journal article; Peer reviewed, 2021)

  Renal fibrosis is a progressive histological manifestation leading to chronic kidney disease (CKD) and associated with mitochondrial dysfunction. In previous work, we showed that Bemcentinib, an Axl receptor tyrosine kinase ...

• Hip fracture in patients with cognitive impairment : Epidemiology and Patient-Reported Outcome Measures. Data from the Norwegian Hip Fracture Register 

  Kristoffersen, Målfrid Holen (Doctoral thesis, 2021-10-22)

  Norway has one of the highest incidences of hip fractures in the world. Every year around 9000 persons are operated for a hip fracture. The mean age of the patients is over 80 years and this injury is often accompanied by ...

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