• The association between visual display terminal use and dry eye: a review 

  Fjærvoll, Haakon Kristoffer Olsen; Fjærvoll, Ketil Andreas Olsen; Magnø, Morten Scherven; Moschowits, Emily; Vehof, Jelle; Dartt, Darlene A.; Utheim, Tor Paaske (Journal article; Peer reviewed, 2021)

  Background: Dry eye disease (DED) is a multifactorial disease of the tear film and ocular surface. It causes ocular symptoms, reduced quality of life and a considerable economic burden on society. Prolonged use of visual ...

• Pellino-2 in nonimmune cells: novel interaction partners and intracellular localization 

  Cristea, Ileana; Bruland, Ove; Rødahl, Eyvind; Bredrup, Cecilie (Journal article; Peer reviewed, 2021)

  Pellino-2 is an E3 ubiquitin ligase that mediates intracellular signaling in innate immune pathways. Most studies of endogenous Pellino-2 have been performed in macrophages, but none in nonimmune cells. Using yeast two-hybrid ...

• Ultrasound and Microbubbles Enhance Uptake of Doxorubicin in Murine Kidneys 

  Eikrem, Øystein Solberg; Kotopoulis, Spiros; Popa, Mihaela-Lucia; Safont, Mireia Mayoral; Fossan, Kjell Ove; Leh, Sabine; Landolt, Lea; Babickova, Janka; Gudbrandsen, Oddrun Anita; Gilja, Odd Helge; Riedel, Bettina Maria Ingeborg; Schjøtt, Jan Didrik; McCormack, Emmet; Marti, Hans-Peter (Journal article; Peer reviewed, 2021-11-29)

  The use of ultrasound and microbubble-enhanced drug delivery, commonly referred to as sonoporation, has reached numerous clinical trials and has shown favourable results. Nevertheless, the microbubbles and acoustic path ...

• Multiple simultaneous embolic cerebral infarctions 11 months after COVID-19 

  Advani, Rajiv; Strømsnes, Torbjørn Austveg; Stjernstrøm, Espen; Lugg, Sebastian T. (Journal article; Peer reviewed, 2021-08-18)

  Background: The coronavirus disease (COVID-19) pandemic has led to an unprecedented worldwide burden of disease. However, little is known of the longer-term implications and consequences of COVID-19. One of these may be a ...

• Pellino-2 intracellular localization and inflammasome overactivation in skin and corneal disease 

  Cristea, Ileana (Doctoral thesis, 2021-12-17)

  Background: Ocular pterygium-digital keloids dysplasia (OPDKD) is a rare, genetic disorder characterized by early onset corneal overgrowth and later development of keloids on distal limbs. We identified a de novo PELI2 ...

• One chance to get it right: Improving clinical handovers for better symptom control at the end of life 

  Goldraij, Gabriel; Tripodoro, Vilma Adriana; Aloisio, Melisa; Castro, Sandra Analiá; Gerlach, Christina; Mayland, Catriona Rachel; Haugen, Dagny Renata Faksvåg (Journal article; Peer reviewed, 2021)

  Poor communication contributes to morbidity and mortality, not only in general medical care but also at the end oflife. This leads to issues relating to symptom control and quality of care. As part of an international ...

• Gender Differences in Kidney Stone Disease (KSD): Findings from a Systematic Review 

  Gillams, Kathryn; Jones, Patrick; Juliebø, Siri Øvereng; Somani, Bhaskar K. (Journal article; Peer reviewed, 2021)

  Purpose of review: The prevalence of kidney stones is rising and historically carries a preponderance for males. However, recent evidence has questioned whether this gender gap is closing. The aim of this systematic review ...

• Temperature-dependent autoactivation associated with clinical variability of PDGFRB Asn666 substitutions 

  Bredrup, Cecilie; Cristea, Ileana; Safieh, Leen Abu; Di Maria, Emilio; Gjertsen, Bjørn Tore; Tveit, Kåre Steinar; Thu, Frode; Bull, Nils; Edward, Deepak P.; Hennekam, Raoul C.; Høvding, Gunnar Jr; Haugen, Olav H.; Houge, Gunnar Douzgos; Rødahl, Eyvind; Bruland, Ove (Journal article; Peer reviewed, 2021)

  Ocular pterygium-digital keloid dysplasia (OPDKD) presents in childhood with ingrowth of vascularized connective tissue on the cornea leading to severely reduced vision. Later the patients develop keloids on digits but are ...

• Vitamin B status and association with antiseizure medication in pregnant women with epilepsy 

  Husebye, Elisabeth Synnøve Nilsen; Riedel, Bettina Maria Ingeborg; Monsen, Anne-Lise Bjørke; Spigset, Olav; Daltveit, Anne Kjersti Nesje; Gilhus, Nils Erik; Bjørk, Marte-Helene (Journal article; Peer reviewed, 2021)

  Objective Antiseizure medication (ASM) use interacts with vitamin B status in nonpregnant epilepsy populations. We aimed to examine the association between ASM and vitamin B status in pregnant women with epilepsy. Methods ...

• Challenges and possible solutions in cross-disciplinary and cross-sectorial research teams within the domain of e-mental health 

  Nordgreen, Tine; Rabbi, Fazle; Tørresen, Jim; Skar, Yngvar Sigmund; Guribye, Frode; Inal, Yavuz; Flobak, Eivind; Wake, Jo Dugstad; Mukhiya, Suresh Kumar; Aminifar, Amin; Myklebost, Sunniva Brurok; Lundervold, Astri J.; Kenter, Robin Maria Francisca; Hammar, Åsa Karin; Kahlon, Smiti; Nordby, Emilie; Sekse, Ragnhild Johanne Tveit; Griffin, Kristine Fonnes; Jakobsen, Petter; Pham, Hoang Minh; Côté-Allard, Ulysse Teller Masao; Noori, Farzan Majeed; Lamo, Yngve (Journal article; Peer reviewed, 2021)

  Purpose: Mental illness presents a huge individual, societal and economic challenges, currently accounting for 20% of the worldwide burden of disease. There is a gap between the need for and access to services. Digital ...

• CRMP5 Antibodies—Diagnostic Challenges 

  Totland, Cecilie; Haugen, Mette; Vedeler, Christian Alexander (Journal article; Peer reviewed, 2021-09-22)

  CRMP5-associated paraneoplastic neurological syndromes (PNS) are rare, and only few studies describe larger cohorts of patients with CRMP5 antibodies. We have included 24 patients with CRMP5 antibodies and compared clinical ...

• Profiling and functional analysis of microRNA deregulation in cancer-associated fibroblasts in oral squamous cell carcinoma depicts an anti-invasive role of microRNA-204 via regulation of their motility 

  Rajthala, Saroj; Min, Anjie; Parajuli, Himalaya; Debnath, Kala Chand; Ljøkjel, Borghild; Hoven, Kristin Marie; Kvalheim, Arild; Lybak, Stein; Neppelberg, Evelyn; Vintermyr, Olav Karsten; Johannessen, Anne Christine; Sapkota, Dipak; Costea, Daniela Elena (Journal article; Peer reviewed, 2021-11-04)

  Background: Knowledge on the role of miR changes in tumor stroma for cancer progression is limited. This study aimed to investigate the role of miR dysregulation in cancer-associated fibroblasts (CAFs) in oral squamous ...

• Targeted Next-Generation Sequencing of Cancer-Related Genes in a Norwegian Patient Cohort With Head and Neck Squamous Cell Carcinoma Reveals Novel Actionable Mutations and Correlations With Pathological Parameters 

  Dongre, Harsh N.; Haave, Hilde; Fromreide, Siren; Erland, Fredrik Atteraas; Moe, Svein Erik Emblem; Dhayalan, Sophia Manueldas; Riis, Rasmus Kopperud; Sapkota, Dipak; Costea, Daniela Elena; Aarstad, Hans Jørgen; Vintermyr, Olav Karsten (Journal article; Peer reviewed, 2021)

  Background: Targeted next-generation sequencing (NGS) is increasingly applied in clinical oncology to advance personalized treatment. Despite success in many other tumour types, use of targeted NGS panels for assisting ...

• Birth Weight Is Associated With Kidney Size in Middle-Aged Women 

  Lillås, Bjørn Steinar; Qvale, Tor Hatlestad; Richter, Blazej Konrad; Vikse, Bjørn Egil (Journal article; Peer reviewed, 2021)

  Introduction Low birth weight (LBW) is associated with increased risk of kidney disease due to lower nephron endowment leading to hyperfiltration and subsequent nephron loss. Kidney size is commonly used as a proxy for ...

• EUS-guided gastroenterostomy with a lumen apposing self-expandable metallic stent relieves gastric outlet obstruction–a Scandinavian case series 

  Havre, Roald Flesland; Dai, C.; Roug, Stine; Novovic, Srdan; Schmidt, P.N.; Feldager, E.; Karstensen, J.G.; Pham, Khanh Do-Cong (Journal article; Peer reviewed, 2021)

  Background: EUS-guided gastroenterostomy (EUS-GE) with lumen-apposing metallic stents (LAMS) in patients with gastric outlet obstruction (GOO) has proven to be an alternative to luminal stenting in the duodenum and surgical ...

• Analysis of salivary mycobiome in a cohort of oral squamous cell carcinoma patients from Sudan identifies higher salivary carriage of malassezia as an independent and favorable predictor of overall survival 

  Mohamed, Nazar; Litlekalsøy, Jorunn; Ahmed, Israa Abdul Rhman; Martinsen, Einar Marius Hjellestad; Furriol, Jessica; Javier-Lopez, Ruben; Elsheikh, Mariam; Mohamed, Nuha Mohamed Gaafar; Morgado, Luis; Mundra, Sunil; Johannessen, Anne Christine; Osman, Tarig Al-Hadi; Nginamau, Elisabeth Sivy; Suleiman, Ahmed; Costea, Daniela Elena (Journal article; Peer reviewed, 2021-10-12)

  Background: Microbial dysbiosis and microbiome-induced inflammation have emerged as important factors in oral squamous cell carcinoma (OSCC) tumorigenesis during the last two decades. However, the “rare biosphere” of the ...

• Base excision repair causes age-dependent accumulation of single-stranded DNA breaks that contribute to Parkinson disease pathology 

  SenGupta, Tanima; Palikaras, Konstantinos; Esbensen, Ying Q.; Konstantinidis, Georgios; Galindo, Francisco Jose Naranjo; Achanta, Kavya; Kassahun, Henok; Stavgiannoudaki, Ioanna; Bohr, Vilhelm A.; Akbari, Mansour; Gaare, Johannes; Tzoulis, Charalampos; Tavernarakis, Nektarios; Nilsen, Hilde (Journal article; Peer reviewed, 2021)

  Aging, genomic stress, and mitochondrial dysfunction are risk factors for neurodegenerative pathologies, such as Parkinson disease (PD). Although genomic instability is associated with aging and mitochondrial impairment, ...

• Cd11c‐cd8 spatial cross presentation: A novel approach to link immune surveillance and patient survival in soft tissue sarcoma 

  Su, Yanhong; Tsagozis, Panagiotis; Papakonstantinou, Andri; Tobin, Nicholas P.; Gultekin, Okan; Malmerfelt, Anna; Ingelshed, Katrine; Neo, Shi Yong; Lundquist, Johanna; Chaabane, Wiem; Nisancioglu, Maya H.; Leiss, Lina; Östman, Arne; Bergh, Jonas; Sedimbi, Saikiran K.; Lehti, Kaisa; Lehti, Kaisa; Lundqvist, Andreas; Stragliotto, Christina L.; Haglund, Felix; Ehnman, Monika (Journal article; Peer reviewed, 2021)

  Checkpoint inhibitors are slowly being introduced in the care of specific sarcoma subtypes such as undifferentiated pleomorphic sarcoma, alveolar soft part sarcoma, and angiosarcoma even though formal indication is lacking. ...

• Short and long-term effects of single and multiple sessions of electroconvulsive therapy on brain gray matter volumes 

  Brancati, Giulio Emilio; Brekke, Njål; Bartsch, Hauke; Sørhaug, Ole Johan Evjenth; Ousdal, Olga Therese; Hammar, Åsa Karin; Schuster, Peter Moritz; Ødegaard, Ketil Joachim; Kessler, Ute; Oltedal, Leif (Journal article; Peer reviewed, 2021)

  Background: Electroconvulsive therapy (ECT) has been shown to induce broadly distributed cortical and subcortical volume increases, more prominently in the amygdala and the hippocampus. Structural changes after one ECT ...

• Distinct Mitochondrial Remodeling During Mesoderm Differentiation in a Human-Based Stem Cell Model 

  Mostafavi, Sepideh; Balafkan, Novin; Pettersen, Ina Katrine Nitschke; Nido, Gonzalo Sanchez; Siller, Richard; Tzoulis, Charalampos; Sullivan, Gareth John; Bindoff, Laurence Albert (Journal article; Peer reviewed, 2021-10-14)

  Given the considerable interest in using stem cells for modeling and treating disease, it is essential to understand what regulates self-renewal and differentiation. Remodeling of mitochondria and metabolism, with the shift ...

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