Department of Clinical Medicine
Nye registreringer
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Cross-sectional analysis of use of real-world data in single technology appraisals of oncological medicine by the National Institute for Health and Care Excellence in 2011-2021
(Journal article; Peer reviewed, 2024)Objectives This study aims to identify how real-world data (RWD) have been used in single technology appraisals (STAs) of cancer drugs by the National Institute for Health and Care Excellence (NICE). Design Cross-sectional ... -
Transient Neonatal Myasthenia Gravis as a Common Complication of a Rare Disease: A Systematic Review
(Journal article; Peer reviewed, 2024)Myasthenia gravis (MG) is a rare autoimmune disease. Transient neonatal myasthenia gravis (TNMG) is caused by pathogenic maternal autoantibodies that cross the placenta and disrupt signaling at the neuromuscular junction. ... -
Malnutrition as a prognostic factor for 2-year mortality in hospitalized patients in Norway: A matched cohort study
(Journal article; Peer reviewed, 2024)Background: Risk of malnutrition and malnutrition have been previously associated with increased risk of mortality. It remains unclear, however, whether the severity of malnutrition differentiates in association with ... -
ESR essentials: MRI of the knee—practice recommendations by ESSR
(Journal article; Peer reviewed, 2024)Many studies and systematic reviews have been published about MRI of the knee and its structures, discussing detailed anatomy, imaging findings, and correlations between imaging and clinical findings. This paper includes ... -
Classification of Vitamin D Status Based on Vitamin D Metabolism: A Randomized Controlled Trial in Hypertensive Patients
(Journal article; Peer reviewed, 2024)Circulating 25-hydroxyvitamin D (25(OH)D) is the generally accepted indicator of vitamin D status. Since hydroxylation of 25(OH)D to 24-25-dihydroxyvitamin D (24,25(OH)2D) is the first step of its catabolism, it has been ... -
Biological implications of the hypervariable VNTR region in the carboxyl ester lipase (CEL) gene
(Doctoral thesis, 2025-05-07)Karboksylester-lipase (CEL) er eit fordøyingsenzym som hovudsakleg blir uttrykt i bukspyttkjertelen. CEL-genet inneheld ein region med repeterte DNA-sekvensar i det siste eksonet, også kalla ein VNTR-region. Repetisjonslengder ... -
The Dark and Gloomy Brain: Grey Matter Volume Alterations in Major Depressive Disorder-Fine-Grained Meta-Analyses
(Journal article; Peer reviewed, 2024)Background: While the brain correlates of major depressive disorder (MDD) have been extensively studied, there is no consensus conclusion so far. Various meta-analyses tried to determine the most consistent findings, but ... -
Common single-base insertions in the VNTR of the carboxyl ester lipase (CEL) gene are benign and also likely to arise somatically in the exocrine pancreas
(Journal article; Peer reviewed, 2024)The CEL gene encodes carboxyl ester lipase, a pancreatic digestive enzyme. CEL is extremely polymorphic due to a variable number tandem repeat (VNTR) located in the last exon. Single-base deletions within this VNTR cause ... -
Factors Underlying the Difference in Response to Fecal Microbiota Transplantation Between IBS Patients with Severe and Moderate Symptoms
(Journal article; Peer reviewed, 2024)Background: Previous studies showed that patients with Severe IBS respond better to fecal microbiota transplantation (FMT) than do those with Moderate IBS. Aims: The present study aimed to determine the effects of the ... -
Generalized myasthenia gravis with acetylcholine receptor antibodies: A guidance for treatment
(Journal article; Peer reviewed, 2024)Background Generalized myasthenia gravis (MG) with antibodies against the acetylcholine receptor is a chronic disease causing muscle weakness. Access to novel treatments warrants authoritative treatment recommendations. ... -
The application of brain organoid for drug discovery in mitochondrial diseases
(Journal article; Peer reviewed, 2024)Mitochondrial diseases are difficult to treat due to the complexity and multifaceted nature of mitochondrial dysfunction. Brain organoids are three-dimensional (3D) structures derived from human pluripotent stem cells ... -
New, simplified versus standard photodynamic therapy (PDT) regimen for superficial and nodular basal cell carcinoma (BCC): A single-blind, non-inferiority, randomised controlled multicentre study
(Journal article; Peer reviewed, 2024)Background Topical photodynamic therapy (PDT) is an approved and widely used treatment for low-risk basal cell carcinoma (BCC), comprising two sessions with an interval of 1 week. Simplification of the treatment course ... -
Outcomes with the Adjustable Transobturator Male System (ATOMS) for the Treatment of Male Stress Urinary Incontinence After Prostate Surgery and the Impact of Previous Radiotherapy
(Journal article; Peer reviewed, 2024)Background and objective The adjustable transobturator male system (ATOMS) is an established treatment for patients with urinary incontinence after prostate surgery. Our objective was to evaluate the efficacy and the ... -
Kitesurfing and snowkiting injuries in Norway: a retrospective study
(Journal article; Peer reviewed, 2024)Background Kiteboarding (kitesurfing on water and snowkiting) is a fairly new sport and is defined as a high-risk sport. The injury rate has been reported to be between 6 and 9 per 1000 h. The aim of the study was to ... -
Facilitators and barriers of implementing end-of-life care volunteering in a hospital in five European countries: the iLIVE study
(Journal article; Peer reviewed, 2024)Background: End-of-life (EoL) care volunteers in hospitals are a novel approach to support patients and their close ones. The iLIVE Volunteer Study supported hospital volunteer coordinators from five European countries to ... -
Adverse Childhood Experiences and the Risk of Multiple Sclerosis Development: A Review of Potential Mechanisms
(Journal article; Peer reviewed, 2024)Adverse childhood experiences (ACEs), such as abuse, neglect, and household dysfunction, contribute to long-term systemic toxic stress and inflammation that may last well into adulthood. Such early-life stressors have been ... -
Healthcare utilization and costs associated with autologous haematopoietic stem cell transplantation in Norwegian patients with relapsing remitting multiple sclerosis
(Journal article; Peer reviewed, 2024)Multiple sclerosis (MS) patients experience long-term deterioration of neurological function, reduced quality of life, long-lasting treatment cycles, and an increased risk of early workability loss imposing an economic ... -
Surveillance after surgery for pancreatic cancer: a global scoping review of guidelines and a nordic Survey of contemporary practice
(Journal article; Peer reviewed, 2024)Objectives Most patients with pancreatic cancer who have undergone surgical resection eventually develop disease recurrence. This study aimed to investigate whether there is evidence to support routine surveillance ... -
The epidemiology and societal costs of myasthenia gravis in Norway: A non-interventional study using national registry data
(Journal article; Peer reviewed, 2024)Background and purpose With the emergence of new treatment options for myasthenia gravis (MG), there is a need for information regarding epidemiology, healthcare utilization, and societal costs to support economic ... -
An analysis of omega-3 clinical trials and a call for personalized supplementation for dementia prevention
(Journal article; Peer reviewed, 2024)Introduction Targeted interventions are needed to delay or prevent the onset of neurodegenerative diseases. Poor dietary habits are associated with cognitive decline, highlighting the benefits of a healthy diet with ...
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