• Studies of mtDNA epigenetics and structural integrity in health, aging, and Parkinson’s disease 

  Guitton, Romain (Doctoral thesis, 2025-06-05)

  Mitokondriell dysfunksjon er et kjennetegn ved aldring og nevrodegenerative sykdommer, inkludert Parkinsons sykdom (PD), men de underliggende mekanismene er fortsatt dårlig forstått. Et voksende interesseområde er mitokondriell ...

• No evidence of extensive non-CpG methylation in mtDNA 

  Guitton, Romain; Sanchez Nido, Gonzalo; Tzoulis, Charalampos (Journal article; Peer reviewed, 2022)

  While most research suggests mitochondrial DNA (mtDNA) harbors low or no methylation, a few studies claim to report evidence of high-level methylation in the mtDNA. The reasons behind these contradictory results are likely ...

• The association of premorbid conditions with 6-month mortality in acutely admitted ICU patients over 80 years 

  de Lange, Dylan W.; Soliman, Ivo W.; Leaver, Susannah; Boumendil, Ariane; Haas, Lenneke E. M.; Watson, Ximena; Boulanger, Carol; Szczeklik, Wojciech; Artigas, Antonio; Morandi, Alessandro; Andersen, Finn Husøy; Jung, Christian; Moreno, Rui; Walther, Sten M; Oeyen, Sandra; Schefold, Joerg C.; Cecconi, Maurizio; Marsh, Brian; Joannidis, Michael; Nalapko, Yuriy; Elhadi, Muhammed; Fjølner, Jesper; Guidet, Bertrand; Flaatten, Hans Kristian (Journal article; Peer reviewed, 2024)

  Background Premorbid conditions influence the outcome of acutely ill adult patients aged 80 years and over who are admitted to the ICU. The aim of this study was to determine the influence of such premorbid conditions ...

• Genetic association of antinuclear antibodies with HLA in JIA patients: a Swedish cohort study 

  Saleh, Raya; Sundberg, Erik; Olsson, Mia; Tengvall, Katarina; Alfredsson, Lars; Kockum, Ingrid; Padyukov, Leonid; Harris, Anna Helena Erlandsson (Journal article; Peer reviewed, 2024)

  Background Juvenile Idiopathic Arthritis (JIA) is a complex autoimmune disease and the most common chronic rheumatological disease affecting children under the age of 16. The etiology of JIA remains poorly understood, ...

• Microbiota and Cytokine Modulation: Innovations in Enhancing Anticancer Immunity and Personalized Cancer Therapies 

  Farhadi Rad, Hamidreza; Tahmasebi, Hamed; Javani, Samaneh; Hemati, Maral; Zakerhamidi, Darya; Hosseini, Masoomeh; Alibabaei, Farnaz; Banihashemian, Seyedeh Zahra; Oksenych, Valentyn; Eslami, Majid (Journal article; Peer reviewed, 2024)

  The gut microbiota plays a crucial role in modulating anticancer immunity, significantly impacting the effectiveness of various cancer therapies, including immunotherapy, chemotherapy, and radiotherapy. Its impact on the ...

• Harmonized Data Quality Indicators Maintain Data Quality in Long-Term Safety Studies Using Multiple Sclerosis Registries/Data Sources: Experience from the CLARION Study 

  Hillert, Jan; Butzkueven, Helmut; Magyari, Melinda; Wergeland, Stig; Moore, Nicholas; Soilu-Hänninen, Merja; Ziemssen, Tjalf; Kuhle, Jens; Pontieri, Luigi; Forsberg, Lars; Aarseth, Jan Harald; Zhu, Chao; Sicignano, Nicholas; Mushnikov, Vasili; Bezemer, Irene; Sabidó, Meritxell (Journal article; Peer reviewed, 2024)

  Purpose: Understanding the long-term safety of disease-modifying therapies for multiple sclerosis (MS) in routine clinical practice can be undertaken through registry-based studies. However, variability of data quality ...

• Different gene expression patterns between mouse and human brain pericytes revealed by single-cell/nucleus RNA sequencing 

  Miao, Yuyang; Li, Weihan; Jeansson, Marie; Mäe, Maarja Andaloussi; Muhl, Lars; He, Liqun (Journal article; Peer reviewed, 2024)

  Aims: Pericytes in the brain play important roles for microvascular physiology and pathology and are affected in neurological disorders and neurodegenerative diseases. Mouse models are often utilized for pathophysiology ...

• A Systematic Review: Fecal Bacterial Profile in Patients with Irritable Bowel Syndrome Analyzed with the GA-Map Dysbiosis Test Based on the 16S rRNA Gene of Bacterial Species or Groups 

  Teige, Erica Sande; Sortvik, Urd; Lied, Gülen Arslan (Journal article; Peer reviewed, 2024)

  Purpose: The diagnosis of irritable bowel syndrome (IBS) is based on symptom-based criteria due to lack of reliable disease-specific biomarkers. Gut microbiota is perturbed in IBS and when comparing different methods used ...

• Neural regeneration in the human central nervous system—from understanding the underlying mechanisms to developing treatments. Where do we stand today? 

  Kvistad, Christopher Elnan; Kråkenes, Torbjørn; Gavasso, Sonia; Bø, Lars (Journal article; Peer reviewed, 2024)

  Mature neurons in the human central nervous system (CNS) fail to regenerate after injuries. This is a common denominator across different aetiologies, including multiple sclerosis, spinal cord injury and ischemic stroke. ...

• Efficacy of metacognitive interventions for psychiatric disorders: a systematic review and meta-analysis 

  Andersson, Erik; Aspvall, Kristina; Schettini, Greta; Kraepelien, Martin; Särnholm, Josefin; Wergeland, Gro Janne Henningsen; Öst, Lars Gøran (Journal article; Peer reviewed, 2025)

  Metacognitive interventions have received increasing interest the last decade and there is a need to synthesize the evidence of these type of interventions. The current study is an updated systematic review and meta-analysis ...

• Group cohesion and alliance predict cognitive-behavioral group treatment outcomes for youth with anxiety disorders 

  Fjermestad, Krister Westlye; Haggkvist Wallin, Malin; Naujokat, Frederike; McLeod, Bryce D.; Silverman, Wendy K.; Öst, Lars-Göran; Lerner, Matthew D.; Heiervang, Einar Røshol; Wergeland, Gro Janne Henningsen (Journal article; Peer reviewed, 2025)

  Knowledge about how to enhance group cognitive behavioral therapy (GCBT) outcomes is needed. In a randomized controlled effectiveness trial, we examined group cohesion (the bond between group members) and the alliance (the ...

• Clinical and laboratory characteristics during a 1-year follow-up in European Lyme neuroborreliosis: A prospective cohort study 

  Solheim, Anne Marit; Skarstein, Ingerid; Quarsten, Hanne; Lorentzen, Åslaug Rudjord; Berg-Hansen, Pål; Eikeland, Randi; Reiso, Harald; Mygland, Åse Daasvand; Ljøstad, Unn (Journal article; Peer reviewed, 2024)

  Background and Purpose We need more knowledge on clinical presentations, time course, biomarkers, and prognosis in European Lyme neuroborreliosis (LNB). Methods A prospective 12-month follow-up of predetermined clinical ...

• Body composition and rupture risk of intracranial aneurysms 

  Løvik, Katja; Laupsa-Borge, Johnny; Logallo, Nicola; Helland, Christian Andre (Journal article; Peer reviewed, 2024)

  Background Rupture of an intracranial aneurysm resulting in a subarachnoid hemorrhage (SAH) is a life-threatening situation. Obesity is an increasing health challenge associated with numerous comorbidities. However, ...

• Use of beta-blockers in patients with ductal carcinoma in situ and risk of invasive breast cancer recurrence: a Swedish retrospective cohort study 

  Strell, Carina; Smith, Daniel Robert; Valachis, Antonis; Woldeyesus, Hellén; Wadsten, Charlotta; Micke, Patrick; Fredriksson, Irma; Schiza, Aglaia (Journal article; Peer reviewed, 2024)

  Background Retrospective observational studies suggest a potential role of beta-blockers as a protective strategy against progression and metastasis in invasive breast cancer. In this context, we investigated the impact ...

• Critical appraisal of the “one-day-per-percent” rule - A register-based observational study 

  BREKKE, RAGNVALD LJONES; Almeland, Stian Kreken; Hufthammer, Karl Ove; Guttormsen, Anne Berit; Hansson, E; Onarheim, Henning (Journal article; Peer reviewed, 2024)

  Background The ”one-day-per-percent” rule states that for burn patients, one day of hospital stay can be expected for each percentage of burned body surface. This study aimed to test the rule's predictive value. Methods The ...

• Patient experiences and perceptions of kidney stone surgery: what lessons can be learned from TikTok? 

  Juliebø-Jones, Patrick; Tzelves, Lazaros; Beisland, Christian; Bosåen, Ingunn Roth; Somani, Bhaskar K. (Journal article; Peer reviewed, 2024)

  Introduction: The aim of this study was to perform an evaluation of patient experiences and perceptions regarding kidney stone surgery on the social media platform TikTok. An increasing number of the public use social media ...

• Interactions between cancer-associated fibroblasts and T-cells: functional crosstalk with targeting and biomarker potential 

  Milosevic, Vladan; Östman, Arne (Journal article; Peer reviewed, 2024)

  Cancer-associated fibroblasts (CAFs) are a heterogeneous cell population recognized as a key component of the tumour microenvironment (TME). Cancer-associated fibroblasts are known to play an important role in maintaining ...

• Remission in schizophrenia spectrum disorders: A randomized trial of amisulpride, aripiprazole and olanzapine 

  Drosos, Petros; Johnsen, Erik; Bartz-Johannessen, Christoffer; Larsen, Tor Kjetil; Reitan, Solveig Klæbo; Rettenbacher, Maria; Kroken, Rune Andreas (Journal article; Peer reviewed, 2024)

  Schizophrenia is a serious mental disorder, and monitoring remission is a widely used measure of effectiveness of the treatment provided. It is very important to identify possible factors correlating with remission. In our ...

• Health-related Quality of Life Assessment in Renal Cell Cancer: A Scoping Review 

  Gross, Franziska; Rasmussen, Ida Marie Lind; Beisland, Elisabeth Grov; Jorem, Gøril Tvedten; Beisland, Christian; Pappot, Helle; Arraras, Juan Ignacio; Pe, Madeline; Holzner, Bernhard A; Wintner, Lisa M (Journal article; Peer reviewed, 2025)

  Background and objective: In oncology, patient-reported outcome measures (PROMs) capturing health-related quality of life (HRQOL) play an increasing role in clinical trials, drug approval, and policy making. This scoping ...

• Multiparametric liver assessment in patients successfully treated for hepatitis C: a 4-year follow-up 

  Trelsgård, Audun M.; Mulabecirovic, Anesa; Leiva, Rafael Alexander Mo; Nordaas, Ingrid Kvåle; Mjelle, Anders Batman; Gilja, Odd Helge; Havre, Roald Flesland (Journal article; Peer reviewed, 2024)

  Background Hepatitis C virus (HCV) is a major cause of chronic liver disease, in which liver stiffness increases. Liver stiffness measurements (LSM) are therefore essential in diagnosing liver diseases and predicting ...

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