Department of Clinical Medicine
Nye registreringer
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Functional evaluation of 16 SCHAD missense variants: Only amino acid substitutions causing congenital hyperinsulinism of infancy lead to loss-of-function phenotypes in vitro
(Journal article; Peer reviewed, 2021)Short‐chain 3‐hydroxyacyl‐CoA dehydrogenase (SCHAD), encoded by the HADH gene, is a ubiquitously expressed mitochondrial enzyme involved in fatty acid oxidation. This protein also plays a role in insulin secretion as ... -
Functional and animal studies of short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD), a fatty acid beta-oxidation enzyme involved in congenital hyperinsulinism of infancy
(Doctoral thesis, 2021-02-16)Short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD) is a mitochondrial enzyme involved in fatty acid β-oxidation and the regulation of β-cell insulin secretion. Its role in insulin secretion became apparent in 2001 when ... -
Benign paroxysmal positional vertigo and treatment in biaxial rotational chair
(Doctoral thesis, 2021-04-23)Benign paroxysmal positional vertigo (BPPV) is the most common cause of peripheral dizziness. The overall aim of this thesis was to examine a new standardised intervention-tool to provide a better treatment for patients ... -
Stem cell function is conserved during shortterm storage of cultured epidermal cell sheets at 12˚C
(Journal article; Peer reviewed, 2020)Transplantation of cultured epidermal cell sheets (CES) can be life-saving for patients with large area burns. CES have also been successfully used to regenerate eye and urethral epithelia in animal models. Short-term ... -
Treatment of horizontal canal BPPV—a randomized sham-controlled trial comparing two therapeutic maneuvers of different speeds
(Journal article; Peer reviewed, 2020)Objectives: To compare the effect of a high‐speed barbecue maneuver with the modified Lempert maneuver and sham in patients with benign paroxysmal positional vertigo (BPPV) of the horizontal canal. Methods: Randomized ... -
Oxidative Stress in the Pathophysiology of Kidney Disease: Implications for Noninvasive Monitoring and Identification of Biomarkers
(Journal article; Peer reviewed, 2020)Kidney disease represents a serious global health problem. One of the main concerns is its late diagnosis, only feasible in a progressed disease state. The lack of a clinical manifestation in the early stages and the fact ... -
Feasibility and acceptability of introducing advance care planning on a thoracic medicine inpatient ward: an exploratory mixed method study
(Journal article; Peer reviewed, 2020)Background and aims Advance care planning (ACP) is communication about wishes and preferences for end-of-life care. ACP is not routinely used in any Norwegian hospitals. We performed a pilot study (2014–2017) introducing ... -
Factors affecting quality of end-of-life hospital care - a qualitative analysis of free text comments from the i-CODE survey in Norway
(Journal article; Peer reviewed, 2020)Background The ERANet-LAC CODE (Care Of the Dying Evaluation) international survey assessed quality of care for dying cancer patients in seven countries, by use of the i-CODE questionnaire completed by bereaved relatives. ... -
Drusenoid pigment epithelial detachment volume is associated with a decrease in best-corrected visual acuity and central retinal thickness: the Norwegian Pigment Epithelial Detachment Study (NORPED) report no. 1
(Journal article; Peer reviewed, 2020)Purpose To investigate the association of drusenoid pigment epithelial detachment (DPED) volume and change in best‐corrected visual acuity (BCVA) and central retinal thickness (CRT) during the growth phase of large ... -
Abnormal Uroguanylin Immunoreactive Cells Density in the Duodenum of Patients with Diarrhea-Predominant Irritable Bowel Syndrome Changes following Fecal Microbiota Transplantation
(Journal article; Peer reviewed, 2020)Altered densities of enteroendocrine cells play an important role in patients with irritable bowel syndrome (IBS). Uroguanylin activates guanylate cyclase-C to regulate intestinal electrolyte and water transport. Aim. To ... -
Multiple sclerosis -the impact of environmental- and lifestyle factors
(Doctoral thesis, 2021-04-15)Background: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS), likely caused by an interaction of genetic and environmental factors. Epstein-Barr virus infection, low serum ... -
Jodkokeboka
(Book, 2021) -
Is There a Trojan Horse to Aggressive Pancreatic Cancer Biology? A Review of the Trypsin-PAR2 Axis to Proliferation, Early Invasion, and Metastasis
(Journal article; Peer reviewed, 2020)Purpose: Pancreatic cancer is one of the most lethal of solid tumors and is associated with aggressive cancer biology. The purpose is to review the role of trypsin and effect on molecular and cellular processes potentially ... -
Exploring the effects of lifestyle on breast cancer risk, age at diagnosis, and survival: the EBBA-Life study
(Journal article; Peer reviewed, 2020)Purpose Whether an unfavorable lifestyle not only affects breast cancer risk, but also influences age at onset of breast cancer and survival, is under debate. Methods In a population-based cohort, the Energy Balance ... -
Hoftelidelser hos barn og unge- utredning og behandling av senfølger.
(Journal article; Peer reviewed, 2020) -
Evaluation of nutritional status and methods to identify nutritional risk in rheumatoid arthritis and spondyloarthritis
(Journal article; Peer reviewed, 2020-11-21)Patients with rheumatoid arthritis (RA) and spondyloarthritis (SpA) experience several nutritional challenges and are prone to develop malnutrition. This observational study aimed to perform a comprehensive nutritional ... -
MRPS23 amplification and gene expression in breast cancer; association with proliferation and the non-basal subtypes
(Journal article; Peer reviewed, 2020-01-16)Purpose MRPS23 is recognized as a driver of proliferation in luminal breast cancer. The aims of the present study were to describe MRPS23 copy number change in breast cancer, and to assess associations between MRPS23 copy ... -
Interictal epileptiform discharges vary across age groups
(Journal article; Peer reviewed, 2020-01)Objective To investigate whether the occurrence and morphology of interictal epileptiform discharges (IEDs) in scalp-EEG change by age. Methods 10,547 patients who had a standard or sleep deprived EEG recording reported ... -
Multidisciplinary intervention versus brief intervention in specialist healthcare. Attempting to improve outcomes for patients on sick leave with musculoskeletal pain
(Doctoral thesis, 2018-12-11)Background: Musculoskeletal pain (MSK), such as low back pain (LBP), neck pain and widespread pain, is among the most common health problems in industrial countries. Subsequently, MSK is associated with substantial healthcare ... -
Do direct oral anticoagulants (DOACs) cause delayed surgery, longer length of hospital stay, and poorer outcome for hip fracture patients?
(Journal article; Peer reviewed, 2020)Purpose The perioperative consequences of direct oral anticoagulants (DOACs) in hip fracture patients are not sufficiently investigated. The primary aim of this study was to determine whether DOAC-users have delayed surgery ...
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