Department of Clinical Medicine
Recent Submissions
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Kunnskapsoppsummering og klassifisering av tiltaket: Mestringskurs for ungdom (DU) ( 3 utg.)
(Journal article; Peer reviewed, 2024)Bakgrunn: Denne artikkelen er en kunnskapsoppsummering om effektene av Depresjonsmestring for ungdom (DU). Artikkelen er en revisjon av tidligere evalueringer av DU i Ungsinn (Wergeland, Skotheim & Kvello, 2016; Kvello, ... -
A Randomised, Double-Blind, Placebo-Controlled, Cross-Over Clinical Trial to Evaluate the Biological Effects and Safety of a Polyphenol Supplement on Healthy Ageing
(Journal article; Peer reviewed, 2024)DailyColors™ is a supplement made up of several phytonutrients that aims to replicate elements from the Mediterranean diet. These include fruit, berry and vegetable extracts that are rich in key phytochemicals such as ... -
Evaluation of dialectical behavior therapy for adolescents in routine clinical practice: a pre-post study
(Journal article; Peer reviewed, 2024)Background Self-harm and suicidal ideation are prevalent among adolescents, cause physical and psychosocial disability, and have potentially life-threatening consequences. Dialectical behavioral therapy for Adolescents ... -
Multi-omics profiling reveals dysregulated ribosome biogenesis and impaired cell proliferation following knockout of CDR2L
(Journal article; Peer reviewed, 2024)Background Cerebellar degeneration-related (CDR) proteins are associated with paraneoplastic cerebellar degeneration (PCD) – a rare, neurodegenerative disease caused by tumour-induced autoimmunity against neural antigens ... -
Genetic associations with psychosis and affective disturbance in Alzheimer's disease
(Journal article; Peer reviewed, 2024)Introduction: Individuals with Alzheimer's disease (AD) commonly experience neuropsychiatric symptoms of psychosis (AD+P) and/or affective disturbance (depression, anxiety, and/or irritability, AD+A). This study's goal was ... -
Platelet transfusions in adult ICU patients with thrombocytopenia: A sub-study of the PLOT-ICU inception cohort study
(Journal article; Peer reviewed, 2024)Background: Platelet transfusions are frequently used in the intensive care unit (ICU), but current practices including used product types, volumes, doses and effects are unknown. Study design and methods: Sub-study of ... -
Holdninger til fysisk aktivitet hos personer i Norge med primær totalprotese i kne eller hofte: En nasjonal spørreundersøkelse
(Journal article; Peer reviewed, 2024)Bakgrunn: I Europa øker andelen proteseoperasjoner. Samtidig går det fysiske aktivitetsnivået i befolkningen ned. Andelen med overvekt og fedme øker. Et transeuropeisk prosjekt for å promotere fysisk aktivitet hos pasienter ... -
Subsequent fracture risk in Norwegians and immigrants with an index forearm fracture: a cohort study
(Journal article; Peer reviewed, 2024)Summary: The current study investigated subsequent fracture risk following a forearm fracture in three country of birth categories: Norway, Europe and North America, and other countries. Subsequent fracture risk was modestly ... -
Stable glioma incidence and increased patient survival over the past two decades in Norway: a nationwide registry-based cohort study
(Journal article; Peer reviewed, 2024)Background: Surveillance of incidence and survival of central nervous system tumors is essential to monitor disease burden and epidemiological changes, and to allocate health care resources. Here, we describe glioma incidence ... -
Activation of Neurotoxic Astrocytes Due to Mitochondrial Dysfunction Triggered by POLG Mutation
(Journal article; Peer reviewed, 2024)Mitochondrial diseases are associated with neuronal death and mtDNA depletion. Astrocytes respond to injury or stimuli and damage to the central nervous system. Neurodegeneration can cause astrocytes to activate and acquire ... -
Cellular adhesion molecules in drug-naïve and previously medicated patients with schizophrenia-spectrum disorders
(Journal article; Peer reviewed, 2024)Background Endothelial inflammation may be involved in the pathogenesis of schizophrenia, and cellular adhesion molecules (CAMs) on endothelial cells may facilitate leukocyte binding and transendothelial migration of cells ... -
Epidemiology and natural history of POLG disease in Norway: a nationwide cohort study
(Journal article; Peer reviewed, 2024)Objective To investigate the prevalence and natural history of POLG disease in the Norwegian population. Methods A national, population-based, retrospective study using demographic, clinical, and genetic data of ... -
Impact of Prosigna test on adjuvant treatment decision in lymph node-negative early breast cancer—a prospective national multicentre study (EMIT-1)
(Journal article; Peer reviewed, 2024)Background EMIT-1 is a national, observational, single-arm trial designed to assess the value of the Prosigna, Prediction Analysis of Microarray using the 50 gene classifier (PAM50)/Risk of Recurrence (ROR), test as a ... -
Risk factors for mortality in patients admitted to a psychiatric acute ward: A prospective cohort study
(Journal article; Peer reviewed, 2024)Introduction: Associations between psychiatric disorders and mortality have been extensively studied, but limited evidence exists regarding influence of clinical characteristics on mortality risk, at the time of acute ... -
Accounting for NAD Concentrations in Genome-Scale Metabolic Models Captures Important Metabolic Alterations in NAD-Depleted Systems
(Journal article; Peer reviewed, 2024)Nicotinamide adenine dinucleotide (NAD) is a ubiquitous molecule found within all cells, acting as a crucial coenzyme in numerous metabolic reactions. It plays a vital role in energy metabolism, cellular signaling, and DNA ... -
Depressive Symptoms Are Not Associated with Predementia Cerebrospinal Fluid Amyloid Pathology
(Journal article; Peer reviewed, 2024)Introduction: Depressive symptoms are associated with Alzheimer’s disease (AD), but their neurobiological and neuropsychological correlates remain poorly understood. We investigate if depressive symptoms are associated ... -
Status epilepticus in POLG disease: a large multinational study
(Journal article; Peer reviewed, 2024)We aimed to provide a detailed phenotypic description of status epilepticus (SE) in a large cohort of patients with POLG disease and identify prognostic biomarkers to improve the management of this life-threatening condition. ... -
Patients with total hip arthroplasty were more physically active 9.6 years after surgery: a case-control study of 429 hip arthroplasty cases and 29,272 participants from a population-based health study
(Journal article; Peer reviewed, 2024)Background and purpose: Few studies report on long-term levels of physical activity after THA compared with a control population. This case-control study aimed to find the long-term habitual level of leisure-time physical ... -
Do emergency medical dispatchers choose the same response to serious injury in men and women – a qualitative study
(Journal article; Peer reviewed, 2024-04-13)Background: Recent research has indicated that sex is an important determinant of emergency medical response in patients with possible serious injuries. Men were found to receive more advanced prehospital treatment and ... -
Inadequate nutritional care for malnourished patients in four university hospitals – The QuaNuT study
(Journal article; Peer reviewed, 2024)Background & Aims: Adequate nutritional care to malnourished patients is described as a human right, and recommendations from nutritional care guidelines are legally binding in Norway. The primary objective of this study ...