Department of Clinical Medicine
Recent Submissions
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Polygenic overlap and shared genetic loci between loneliness, severe mental disorders, and cardiovascular disease risk factors suggest shared molecular mechanisms
(Journal article; Peer reviewed, 2021)Clinical and epidemiological evidence suggest that loneliness is associated with severe mental disorders (SMDs) and increases the risk of cardiovascular disease (CVD). However, the mechanisms underlying the relationship ... -
Short tau inversion recovery MRI of Modic changes: a reliability study
(Journal article; Peer reviewed, 2020)Background Limited reliability data exist for evaluation of spinal edema changes on magnetic resonance imaging (MRI) with short tau inversion recovery (STIR) sequences. Purpose To assess the inter-observer reliability ... -
Gastrointestinal Ultrasound Can Predict Endoscopic Activity in Crohn’s Disease
(Journal article; Peer reviewed, 2020-04-24)Purpose To explore the ability of gastrointestinal ultrasound (GIUS) to separate patients in endoscopic remission from patients with active disease in a heterogeneous hospital cohort with Crohn’s disease (CD). Materials ... -
The association between lithium use and neurocognitive performance in patients with bipolar disorder
(Journal article; Peer reviewed, 2020)Lithium remains the gold standard for the treatment of bipolar disorder (BD); however, its use has declined over the years mainly due to the side effects and the subjective experience of cognitive numbness reported by ... -
Cerebellar degeneration-related proteins in anti-Yo associated paraneoplastic cerebellar degeneration
(Doctoral thesis, 2021-06-25)Background: Paraneoplastic neurological syndromes (PNS) are rare immune-mediated diseases triggered by cancer, and characterized by circulating onconeural antibodies directed against antigens expressed by neurons and tumor ... -
Sepsis at ICU admission does not decrease 30-day survival in very old patients: a post-hoc analysis of the VIP1 multinational cohort study
(Journal article; Peer reviewed, 2020)Background The number of intensive care patients aged ≥ 80 years (Very old Intensive Care Patients; VIPs) is growing. VIPs have high mortality and morbidity and the benefits of ICU admission are frequently questioned. ... -
Iodine content of dietary supplements available on the Norwegian market
(Master thesis, 2021-05-18)Background: Insufficient iodine intake has been reported in groups of the Norwegian population. This is of concern, as iodine is an essential nutrient required throughout life. With few dietary sources of iodine, supplementation ... -
Metallionenivåer i blod fra pasienter med metall-mot-metall-hofteprotese
(Journal article; Peer reviewed, 2021)Bakgrunn: BHR-protese (Birmingham hip resurfacing) er satt inn i hoften til 445 personer i Norge. Bivirkninger av metallfrigjøring fra metall-mot-metall-leddflater av kobolt-krom-legering kan forekomme. Målet med studien ... -
Gut microbiota and therapeutic approaches for dysbiosis in irritable bowel syndrome: recent developments and future perspectives
(Journal article; Peer reviewed, 2020)Increased knowledge regarding the implications of gut microbiota in irritable bowel syndrome (IBS) suggests that a disturbed intestinal microenvironment (dysbiosis) might promote the development and maintenance of IBS ... -
The epithelial–mesenchymal transition regulators Twist, Slug, and Snail are associated with aggressive tumour features and poor outcome in prostate cancer patients
(Journal article; Peer reviewed, 2021)The prognostic importance of transcription factors promoting epithelial–mesenchymal transition (EMT) and angiogenesis has not been well explored in prostate cancer patients with long follow-up, nor the interplay between ... -
Tumour texture features from preoperative CT predict high-risk disease in endometrial cancer
(Journal article; Peer reviewed, 2021-01)BACKGROUND To enable more individualised treatment of endometrial cancer, improved methods for preoperative tumour characterization are warranted. Texture analysis is a method for quantification of heterogeneity in images, ... -
What Do We Mean by "Stone Free," and How Accurate Are Urologists in Predicting Stone-Free Status Following Ureteroscopy?
(Journal article; Peer reviewed, 2021)Background and Purpose: No consensus exists on how stone-free rates (SFRs) should be reported after stone treatment. The aim of this study was to assess how accurate urologists predict their patients being stone free after ... -
Ureteral Strictures Following Ureteroscopic Stone Treatment
(Journal article; Peer reviewed, 2020)Background and Purpose: Ureteral stricture is a rare, but serious complication following ureteroscopy (URS) for stones. The aim of this study was to investigate how many patients ended up with a ureteral stricture after ... -
Post hepatectomy liver failure (PHLF) – Recent advances in prevention and clinical management
(Journal article; Peer reviewed, 2021)Background Posthepatectomy liver failure (PHLF) is a relatively rare but feared complication following liver surgery, and associated with high morbidity, mortality and cost implications. Significant advances have been ... -
Oedema on STIR modified the effect of amoxicillin as treatment for chronic low back pain with Modic changes—subgroup analysis of a randomized trial
(Journal article; Peer reviewed, 2021)Objective To evaluate potential MRI-defined effect modifiers of amoxicillin treatment in patients with chronic low back pain and type 1 or 2 Modic changes (MCs) at the level of a previous lumbar disc herniation (index ... -
Wearing-off at the end of natalizumab dosing interval and risk of MS disease activity: A prospective 1-year follow-up study
(Journal article; Peer reviewed, 2020)Natalizumab effectively prevents disease activity in relapsing-remitting multiple sclerosis by binding α4 integrin and inhibiting leukocyte migration to the central nervous system. We recently reported an association between ... -
Strategies for the delay of surgery in the management of resectable hepatobiliary malignancies during the COVID-19 pandemic
(Journal article; Peer reviewed, 2020)Objective: We aimed to review data about delaying strategies for the management of hepatobiliary cancers requiring surgery during the covid-19 pandemic. Background: Given the covid-19 pandemic, many jurisdictions, to spare ... -
The impact of lifestyle factors on disease risk and long-term disability progression in multiple sclerosis
(Doctoral thesis, 2021-06-04)Background: Multiple sclerosis (MS) is a disabling inflammatory disease of the central nervous system (CNS) likely caused by genetic susceptible variants and environmental triggers. Low vitamin D levels and smoking are ... -
Sex-specific outcome disparities in very old patients admitted to intensive care medicine: a propensity matched analysis
(Journal article; Peer reviewed, 2020)Female and male very elderly intensive patients (VIPs) might differ in characteristics and outcomes. We aimed to compare female versus male VIPs in a large, multinational collective of VIPs with regards to outcome and ... -
Personalized estimation of one-year mortality risk after elective hip or knee arthroplasty for osteoarthritis.
(Journal article; Peer reviewed, 2020)Aims To develop and validate patient-centred algorithms that estimate individual risk of death over the first year after elective joint arthroplasty surgery for osteoarthritis. Methods A total of 763,213 hip and knee ...
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