• Clinical predictors of non-response to lithium treatment in the Pharmacogenomics of Bipolar Disorder (PGBD) study 

  Lin, Yan; Maihofer, Adam X.; Stapp, Emma; Ritchey, Megan; Alliey-Rodriguez, Ney; Anand, Amit; Balaraman, Yokesh; Berrettini, Wade H; Bertram, Holli; Bhattacharjee, Abesh; Calkin, Cynthia V.; Conroy, Carla; Coryell, William; D´Arcangelo, Nicole; DeModena, Anna; Biernacka, Joanna M.; Fisher, Carrie; Frazier, Nicole; Frye, Mark; Gao, Keming; Garnham, Julie; Gershon, Elliot; Glazer, Kara; Goes, Fernando S; Goto, Toyomi; Karberg, Elizabeth; Harrington, Gloria J.; Jakobsen, Petter; Kamali, Masoud; Kelly, Marisa; Leckband, Susan G.; Lohoff, Falk W.; Stautland, Andrea; McCarthy, Michael J.; McInnis, Melvin G.; Mondimore, Francis; Morken, Gunnar; Nurnberger, John I.; Ødegaard, Ketil Joachim; Syrstad, Vigdis Elin Giæver; Ryan, Kelly; Schinagle, Martha; Schøyen, Helle Kristine; Andreassen, Ole; Shaw, Martha; Shilling, Paul D.; Slaney, Claire; Tarwater, Bruce; Calabrese, Joseph R.; Alda, Martin; Nievergelt, Caroline M.; Zandi, Peter P.; Kelsoe, John R. (Journal article; Peer reviewed, 2021)

  Background Lithium is regarded as a first-line treatment for bipolar disorder (BD), but partial response and non-response commonly occurs. There exists a need to identify lithium non-responders prior to initiating treatment. ...

• Prevalence of atherosclerosis and association with 5-year outcome: The Norwegian Stroke in the Young Study 

  Nawaz, Beenish; Fromm, Annette; Øygarden, Halvor; Eide, Geir E; Saeed, Sahrai; Meijer, Rudy; Bots, Michiel L; Sand, Kristin M; Thomassen, Lars; Næss, Halvor; Waje-Andreassen, Ulrike (Journal article; Peer reviewed, 2021)

  Objectives: We studied the prevalence of atherosclerosis among ischaemic stroke patients ≤60 years and controls at the time of the index stroke, and its association with occurrence of new cardiovascular events (CVEs) and ...

• Cardiovascular changes in young renal failure patients 

  Tøndel, Camilla; Marti, Hans Peter (Journal article; Peer reviewed, 2021)

  Progresses in medical care of severe kidney disease and congenital anomalies of kidney and urinary tract make it possible for a higher percentage of young renal failure patients to survive and enter adulthood. There is ...

• Aetiological risk factors are associated with distinct imaging findings in patients with chronic pancreatitis: A study of 959 cases from the Scandinavian Baltic Pancreatic Club (SBPC) imaging database 

  Engjom, Trond; Nordaas, Ingrid Kvåle; Tjora, Erling; Dimcevski, Georg Gjorgji; Haldorsen, Ingfrid S.; Olesen, Søren Schou; Drewes, Asbjørn Mohr; Zviniene, Kristina; Barauskas, Giedrus; Riis Jespersen, Hans Søe; Jensen, Nanna; Borch, Anders; Nøjgaard, Camilla; Novovic, Srdan; Kardasheva, Svetlana S.; Okhlobystin, Alexey; Hauge, Truls; Waage, Anne; Frøkjær, Jens Brøndum (Journal article; Peer reviewed, 2021)

  Objectives The relation between aetiology and structural changes of the pancreas in patients with chronic pancreatitis (CP) is not fully understood. Earlier studies are limited by focusing on selected factors in studies ...

• Antiseizure medication in patients with Glioblastoma- a collaborative cohort study 

  Knudsen-Baas, Kristin M.; Storstein, Anette; Zarabla, Alessia; Maialetti, Andrea; Giannarelli, Diana; Beghi, Ettore; Maschio, Marta (Journal article; Peer reviewed, 2021)

  Purpose We investigated, whether epileptic seizures (ES) as presenting symptom in adult patients with GBM are associated with better Overall Survival (OS) compared to ES presenting later during the course of GBM, and ...

• Vitrectomy-Assisted Biopsy: An in vitro Study on the Impact of Cut Rate and Probe Size 

  Ulltang, Erlend; Kiilgaard, Jens Folke; Mola, Nazanin; Scheie, David; Heegaard, Steffen; Krohn, Jørgen Gitlesen (Journal article; Peer reviewed, 2021)

  Purpose: The aim of this study was to optimize the technique of performing vitrectomy-assisted biopsy of intraocular tumors by comparing the cytohistological findings in specimens obtained with different vitrectomy probes ...

• Multifaceted intervention including Facebook-groups to improve guideline-adherence in ICU: A quasi-experimental interrupted time series study 

  Petosic, Antonija; Småstuen, Milada C.; Beeckman, Dimitri; Flaatten, Hans; Sunde, Kjetil; Wøien, Hilde (Journal article; Peer reviewed, 2021)

  Background: The impact of social media, with its speed, reach and accessibility, in interventions aimed to improve adherence to guidelines such as assessment of Pain, Agitation/Sedation and Delirium (PAD) in intensive care ...

• Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores 

  de Rojas, Itziar; Moreno-Grau, Sonia; Tesi, Niccolo; Grenier-Boley, Benjamin; Andrade, Victor; Jansen, Iris E.; Rongve, Arvid; Aarsland, Dag; Selbæk, Geir; Saltvedt, Ingvild; Sando, Sigrid Botne; Djurovic, Srdjan; Andreassen, Ole; Pedersen, Nancy L.; Stringa, Najada; Zettergren, Anna; Hernández, Isabel; Montrreal, Laura; Antunez, Carmen; Antonell, Anna; Tankard, Rick; Bis, Joshua C.; Sims, Rebecca; Bellenguez, Celine; Quintela, Inés; González-Pérez, Antonio; Calero, Miguel; Franco-Macias, Emilio; Macias, Juan; Blesa, Rafael; Cervera-Carles, Laura; Menendez-Gonzalez, Manuel; Frank-Garcia, Ana; Royo, José Luis; Moreno, Fermin; Vilas, Raquel Huerto; Baquero, Miquel; Diez-Fairen, Monica; Lage, Carmen; García-Madrona, Sebastian; Garcia-Gonzalez, Pablo; Alarcón-Martín, Emilio; Valero, Sergi; Sotolongo-Grau, Oscar; Ullgren, Abbe; Naj, Adam C.; Lemstra, Afina W.; Benaque, Alba; Perez-Cordon, Alba; Benussi, Alberto; Rabano, Alberto (Journal article; Peer reviewed, 2021)

  Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical ...

• Clinical responses following inspiratory muscle training in exercise-induced laryngeal obstruction 

  Sandnes, Astrid; Andersen, Tiina Maarit; Clemm, Hege Synnøve Havstad; Hilland, Magnus; Heimdal, John-Helge; Halvorsen, Thomas; Røksund, Ola Drange; Vollsæter, Maria (Journal article; Peer reviewed, 2021)

  Purpose Exercise-induced laryngeal obstruction (EILO) is relatively common in young people. Treatment rests on poor evidence; however, inspiratory muscle training (IMT) has been proposed a promising strategy. We aimed to ...

• CSF neurofilament light chain predicts 10-year clinical and radiologic worsening in multiple sclerosis 

  Bhan, Alok; Jacobsen, Cecilie; Dalen, Ingvild; Bergsland, Niels; Zivadinov, Robert; Alves, Guido Werner; Myhr, Kjell-Morten; Farbu, Elisabeth (Journal article; Peer reviewed, 2021)

  Background Neurofilament light chain (NfL) is an attractive biomarker of disease activity and progression in MS, but there is a lack in long-term prognostic data. Objective To test the long-term clinical and radiological ...

• Prevalence of patients “at risk of malnutrition” and nutritional routines among surgical and non-surgical patients at a large university hospital during the years 2008–2018 

  Skeie, Eli; Sygnestveit, Kari; Nilsen, Roy M.; Harthug, Stig; Koch, Anne Mette; Tangvik, Randi Julie (Journal article; Peer reviewed, 2021)

  Background & aims: Being “at risk of malnutrition”, which includes both malnutrition and the risk to be so, is associated with increased morbidity and mortality in both surgical and non-surgical patients. Several strategies ...

• Increased risk of hospitalisation and intensive care admission associated with reported cases of SARS-CoV-2 variants B.1.1.7 and B.1.351 in Norway, December 2020-May 2021 

  Veneti, Lamprini; Seppälä, Elina Marjukka; Storm, Margrethe Larsdatter; Valcarcel Salamanca, Beatriz; Buanes, Eirik Alnes; Aasand, Nina Therese; Naseer, Mohammed Umaer; Bragstad, Karoline; Hungnes, Olav; Bøås, Håkon; Kvåle, Reidar; Samareh Golestani, Karan; Feruglio, Siri Laura; Vold, Line; Nygård, Karin Maria; Whittaker, Robert Neil (Journal article; Peer reviewed, 2021)

  Introduction Since their emergence, SARS-CoV-2 variants of concern (VOC) B.1.1.7 and B.1.351 have spread worldwide. We estimated the risk of hospitalisation and admission to an intensive care unit (ICU) for infections ...

• Use of quantitative pathology to improve grading and predict prognosis in tumours of the gastrointestinal tract 

  Lea, Dordi (Doctoral thesis, 2022-01-14)

  Cancer represents a formidable health burden and was the second leading cause of death globally in 2018. In Norway, almost 35000 new cancer cases were reported in 2019. For colon cancer, the incidence and mortality rates ...

• Current status of thulium fibre laser lithotripsy: an up-to-date review 

  Jones, Patrick; Beisland, Christian; Ulvik, Øyvind (Journal article; Peer reviewed, 2021)

  Objective To perform an up-to-date review to scope the current status of the thulium fibre laser (TFL) in the setting of stone lithotripsy and provide a guide for the clinical urologist. Methods A review of world ...

• How Does Implant Survivorship Vary with Different Corail Femoral Stem Variants? Results of 51,212 Cases with Up to 30 Years Of Follow-up from the Norwegian Arthroplasty Register 

  Melbye, Silje Marie; Haug, Sofie Cecilia Dietrich; Fenstad, Anne Marie; Furnes, Ove Nord; Gjertsen, Jan-Erik; Hallan, Geir (Journal article; Peer reviewed, 2021)

  Background: The Corail® cementless stem (DePuy Synthes) has been used in Norway since 1987 and is one of the most frequently used stems in THA worldwide. Although the published survival results of the standard Corail stem ...

• Variable expression of eighteen common housekeeping genes in human non-cancerous kidney biopsies 

  Strauss, Philipp; Furriol, Jessica; mikkelsen, Håvard (Journal article; Peer reviewed, 2021)

  Housekeeping, or reference genes (RGs) are, by definition, loci with stable expression profiles that are widely used as internal controls to normalize mRNA levels. However, due to specific events, such as pathological ...

• Gastrointestinal transit and contractility in diabetic constipation: A wireless motility capsule study on diabetes patients and healthy controls 

  Sangnes, Dag A.; Lundervold, Katarina; Bekkelund, Mattis; Volkmann, Hilde Løland Von; Berentsen, Birgitte; Gilja, Odd Helge; Dimcevski, Georg; Søfteland, Eirik (Journal article; Peer reviewed, 2021)

  Background: Diabetic constipation is traditionally attributed to slow colonic transit, despite limited evidence. More than half of patients find treatment unsatisfactory. To improve treatment, there is a need for better ...

• ILIVE Project Volunteer study. Developing international consensus for a European Core Curriculum for hospital end-of-life-care volunteer services, to train volunteers to support patients in the last weeks of life: A Delphi study 

  McGlinchey, Tamsin; Mason, Stephen R; Smeding, Ruthmarijke; Goosensen, Anne; Ruiz-Torreras, Inmaculada; Haugen, Dagny Renata Faksvåg; Bakan, Miša; Ellershaw, John E (Journal article; Peer reviewed, 2021)

  Background: Volunteers make a huge contribution to the health and wellbeing of the population and can improve satisfaction with care especially in the hospice setting. However, palliative and end-of-life-care volunteer ...

• Management and outcomes in critically ill nonagenarian versus octogenarian patients 

  Bruno, Raphael Romano; Wernly, Bernhard; Kelm, Malte; Boumendil, Ariane; Morandi, Alessandro; Andersen, Finn H.; Artigas, Antonio; Finazzi, Stefano; Cecconi, Maurizio; Christensen, Steffen; Faraldi, Loredana; Lichtenauer, Michael; Flaatten, Hans; Jung, Christian (Journal article; Peer reviewed, 2021)

  Background: Intensive care unit (ICU) patients age 90 years or older represent a growing subgroup and place a huge financial burden on health care resources despite the benefit being unclear. This leads to ethical problems. ...

• EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1 

  Ando, Toshinori; Arang, Nadia; Wang, Zhiyong; Costea, Daniela Elena; Feng, Xiaodong; Goto, Yusuke; Izumi, Hiroki; Gilardi, Mara; Ando, Kazuyo; Gutkind, J. Silvio (Journal article; Peer reviewed, 2021)

  The Hippo pathway is frequently dysregulated in cancer, leading to the unrestrained activity of its downstream targets, YAP/TAZ, and aberrant tumor growth. However, the precise mechanisms leading to YAP/TAZ activation in ...

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