Department of Clinical Medicine
Nye registreringer
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Factors associated with self-rated health in a Norwegian population of older people participating in a preventive home visit program: a cross-sectional study
(Journal article; Peer reviewed, 2020)Background Assessing self-rated health by preventive home visits of older people can provide information about the person’s well-being, quality of life and risk of developing illness. The aim of this study was to examine ... -
Paraneoplastic cerebellar degeneration: Characterizing the Yo antibody antigens
(Doctoral thesis, 2021-03-16)Background: The pathogenesis of paraneoplastic cerebellar degeneration (PCD) with Yo-antibodies is unclear. The disease is generally accepted as immune-mediated, but whether the Yo antibodies themselves are pathogenic ... -
Early diagnosis is associated with improved clinical outcomes in benign esophageal perforation: an individual patient data meta‑analysis
(Journal article; Peer reviewed, 2020)Background Time of diagnosis (TOD) of benign esophageal perforation is regarded as an important risk factor for clinical outcome, although convincing evidence is lacking. The aim of this study is to assess whether time ... -
Liver Elastography in Primary Sclerosing Cholangitis Patients Using Three Different Scanner Systems
(Journal article; Peer reviewed, 2020)The aim of the study described here was to characterize three different liver elastography methods in primary sclerosing cholangitis (PSC) patients, for the first time exploring 2-D shear wave elastography (2-D-SWE) in PSC ... -
Mental health and health related quality of life in mitochondrial POLG disease
(Journal article; Peer reviewed, 2020)We aimed to assess the impact of POLG disease on mental health and quality of life in 15 patients using the Symptom Checklist-90-R (SCL-90-R) and Short-Form 36 Health Survey (RAND-36). We found increased scores in all nine ... -
Acute effects of whey protein on energy intake, appetite and gastric emptying in younger and older, obese men
(Journal article; Peer reviewed, 2020)Background Obesity is becoming more prevalent in older people. A management strategy in obese, young adults is to increase dietary protein relative to other macronutrients. It is not clear if this is effective in obese, ... -
Research Review: Recommendations for reporting on treatment trials for child and adolescent anxiety disorders – an international consensus statement
(Journal article; Peer reviewed, 2020)Background Anxiety disorders in children and young people are common and bring significant personal and societal costs. Over the last two decades, there has been a substantial increase in research evaluating psychological ... -
Differential transcript usage in the Parkinson’s disease brain
(Peer reviewed; Journal article, 2020)Studies of differential gene expression have identified several molecular signatures and pathways associated with Parkinson’s disease (PD). The role of isoform switches and differential transcript usage (DTU) remains, ... -
Virus transmission during orthopedic surgery on patients with COVID-19 – a brief narrative review
(Journal article; Peer reviewed, 2020)Background and purpose — COVID-19 is among the most impactful pandemics that the society has experienced. Orthopedic surgery involves procedures generating droplets and aerosols and there is concern amongst surgeons that ... -
The association of partial pressures of oxygen and carbon dioxide with neurological outcome after out-of-hospital cardiac arrest: an explorative International Cardiac Arrest Registry 2.0 study
(Journal article; Peer reviewed, 2020)Background Exposure to extreme arterial partial pressures of oxygen (PaO2) and carbon dioxide (PaCO2) following the return of spontaneous circulation (ROSC) after out-of-hospital cardiac arrest (OHCA) is common and may ... -
The short-term impact of methylprednisolone on patient-reported sleep in patients with advanced cancer in a randomized, placebo-controlled, double-blind trial
(Journal article; Peer reviewed, 2020)Purpose: Although corticosteroids are frequently used in patients with advanced cancer, few studies have examined the impact of these drugs on patient-reported sleep. We aimed to examine the short-term impact of ... -
Intrauterine growth restriction, preterm birth and risk of end-stage renal disease during the first 50 years of life
(Journal article; Peer reviewed, 2020)Background: Low birth weight (LBW) is associated with a higher risk of end-stage renal disease (ESRD). The relative impacts of absolute birth weight, birth weight in relation to gestational age and preterm birth are, ... -
Global FKRP Registry: observations in more than 300 patients with Limb Girdle Muscular Dystrophy R9
(Journal article; Peer reviewed, 2020-04)Objective The Global FKRP Registry is a database for individuals with conditions caused by mutations in the Fukutin‐Related Protein (FKRP) gene: limb girdle muscular dystrophy R9 (LGMDR9, formerly LGMD2I) and congenital ... -
Hip fracture treatment in Norway - deviation from evidence-based treatment guidelines: data from the Norwegian Hip Fracture Register, 2014 to 2018
(Journal article, 2020)Aims The aim of this study was to describe variation in hip fracture treatment in Norway expressed as adherence to international and national evidence-based treatment guidelines, to study factors influencing deviation ... -
Exploring the genetic contribution to idiopathic Parkinson disease
(Doctoral thesis, 2021-03-05)Background: Parkinson disease (PD) is a major cause of death and disability and has a devastating global socioeconomic impact. It affects 1-2% of the population above the age of 65 and its prevalence increases as the ... -
Meta-analysis of whole-exome sequencing data from two independent cohorts finds no evidence for rare variant enrichment in Parkinson disease associated loci
(Journal article; Peer reviewed, 2020-10-01)Parkinson disease (PD) is a complex neurodegenerative disorder influenced by both environmental and genetic factors. While genome wide association studies have identified several susceptibility loci, many causal variants ... -
The power of empirical data; lessons from the clinical registry initiatives in Scandinavian cancer care
(Journal article; Peer reviewed, 2020)Background In Scandinavia, there is a strong tradition for research and quality monitoring based on registry data. In Denmark, Norway and Sweden, 63 clinical registries collect data on disease characteristics, treatment ... -
Comparable Increases in Dural Sac Area After Three Different Posterior Decompression Techniques for Lumbar Spinal Stenosis: Radiological Results From a Randomized Controlled Trial in the NORDSTEN Study
(Journal article; Peer reviewed, 2020)Purpose: To investigate changes in dural sac area after three different posterior decompression techniques in patients undergoing surgery for lumbar spinal stenosis. Decompression of the nerve roots is the main surgical ... -
Effects of using the MyFood decision support system on hospitalized patients' nutritional status and treatment: A randomized controlled trial
(Journal article; Peer reviewed, 2020)Background & aims Compliance to guidelines for disease-related malnutrition is documented as poor. The practice of using paper-based dietary recording forms with manual calculation of the patient's nutritional intake is ... -
Cemented or uncemented hemiarthroplasty for femoral neck fracture? Data from the Norwegian Hip Fracture Register
(Journal article; Peer reviewed, 2020)Background A displaced femoral neck fracture in patients older than 70 years is a serious injury that influences the patient’s quality of life and can cause serious complications or death. Previous national guidelines ...
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