Department of Clinical Medicine
Recent Submissions
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Pellino-2 in nonimmune cells: novel interaction partners and intracellular localization
(Journal article; Peer reviewed, 2021)Pellino-2 is an E3 ubiquitin ligase that mediates intracellular signaling in innate immune pathways. Most studies of endogenous Pellino-2 have been performed in macrophages, but none in nonimmune cells. Using yeast two-hybrid ... -
Ultrasound and Microbubbles Enhance Uptake of Doxorubicin in Murine Kidneys
(Journal article; Peer reviewed, 2021-11-29)The use of ultrasound and microbubble-enhanced drug delivery, commonly referred to as sonoporation, has reached numerous clinical trials and has shown favourable results. Nevertheless, the microbubbles and acoustic path ... -
Pellino-2 intracellular localization and inflammasome overactivation in skin and corneal disease
(Doctoral thesis, 2021-12-17)Background: Ocular pterygium-digital keloids dysplasia (OPDKD) is a rare, genetic disorder characterized by early onset corneal overgrowth and later development of keloids on distal limbs. We identified a de novo PELI2 ... -
Multiple simultaneous embolic cerebral infarctions 11 months after COVID-19
(Journal article; Peer reviewed, 2021-08-18)Background: The coronavirus disease (COVID-19) pandemic has led to an unprecedented worldwide burden of disease. However, little is known of the longer-term implications and consequences of COVID-19. One of these may be a ... -
One chance to get it right: Improving clinical handovers for better symptom control at the end of life
(Journal article; Peer reviewed, 2021)Poor communication contributes to morbidity and mortality, not only in general medical care but also at the end oflife. This leads to issues relating to symptom control and quality of care. As part of an international ... -
Gender Differences in Kidney Stone Disease (KSD): Findings from a Systematic Review
(Journal article; Peer reviewed, 2021)Purpose of review: The prevalence of kidney stones is rising and historically carries a preponderance for males. However, recent evidence has questioned whether this gender gap is closing. The aim of this systematic review ... -
Temperature-dependent autoactivation associated with clinical variability of PDGFRB Asn666 substitutions
(Journal article; Peer reviewed, 2021)Ocular pterygium-digital keloid dysplasia (OPDKD) presents in childhood with ingrowth of vascularized connective tissue on the cornea leading to severely reduced vision. Later the patients develop keloids on digits but are ... -
Vitamin B status and association with antiseizure medication in pregnant women with epilepsy
(Journal article; Peer reviewed, 2021)Objective Antiseizure medication (ASM) use interacts with vitamin B status in nonpregnant epilepsy populations. We aimed to examine the association between ASM and vitamin B status in pregnant women with epilepsy. Methods ... -
Challenges and possible solutions in cross-disciplinary and cross-sectorial research teams within the domain of e-mental health
(Journal article; Peer reviewed, 2021)Purpose: Mental illness presents a huge individual, societal and economic challenges, currently accounting for 20% of the worldwide burden of disease. There is a gap between the need for and access to services. Digital ... -
CRMP5 Antibodies—Diagnostic Challenges
(Journal article; Peer reviewed, 2021-09-22)CRMP5-associated paraneoplastic neurological syndromes (PNS) are rare, and only few studies describe larger cohorts of patients with CRMP5 antibodies. We have included 24 patients with CRMP5 antibodies and compared clinical ... -
Profiling and functional analysis of microRNA deregulation in cancer-associated fibroblasts in oral squamous cell carcinoma depicts an anti-invasive role of microRNA-204 via regulation of their motility
(Journal article; Peer reviewed, 2021-11-04)Background: Knowledge on the role of miR changes in tumor stroma for cancer progression is limited. This study aimed to investigate the role of miR dysregulation in cancer-associated fibroblasts (CAFs) in oral squamous ... -
Targeted Next-Generation Sequencing of Cancer-Related Genes in a Norwegian Patient Cohort With Head and Neck Squamous Cell Carcinoma Reveals Novel Actionable Mutations and Correlations With Pathological Parameters
(Journal article; Peer reviewed, 2021)Background: Targeted next-generation sequencing (NGS) is increasingly applied in clinical oncology to advance personalized treatment. Despite success in many other tumour types, use of targeted NGS panels for assisting ... -
Birth Weight Is Associated With Kidney Size in Middle-Aged Women
(Journal article; Peer reviewed, 2021)Introduction Low birth weight (LBW) is associated with increased risk of kidney disease due to lower nephron endowment leading to hyperfiltration and subsequent nephron loss. Kidney size is commonly used as a proxy for ... -
EUS-guided gastroenterostomy with a lumen apposing self-expandable metallic stent relieves gastric outlet obstruction–a Scandinavian case series
(Journal article; Peer reviewed, 2021)Background: EUS-guided gastroenterostomy (EUS-GE) with lumen-apposing metallic stents (LAMS) in patients with gastric outlet obstruction (GOO) has proven to be an alternative to luminal stenting in the duodenum and surgical ... -
Analysis of salivary mycobiome in a cohort of oral squamous cell carcinoma patients from Sudan identifies higher salivary carriage of malassezia as an independent and favorable predictor of overall survival
(Journal article; Peer reviewed, 2021-10-12)Background: Microbial dysbiosis and microbiome-induced inflammation have emerged as important factors in oral squamous cell carcinoma (OSCC) tumorigenesis during the last two decades. However, the “rare biosphere” of the ... -
Base excision repair causes age-dependent accumulation of single-stranded DNA breaks that contribute to Parkinson disease pathology
(Journal article; Peer reviewed, 2021)Aging, genomic stress, and mitochondrial dysfunction are risk factors for neurodegenerative pathologies, such as Parkinson disease (PD). Although genomic instability is associated with aging and mitochondrial impairment, ... -
Cd11c‐cd8 spatial cross presentation: A novel approach to link immune surveillance and patient survival in soft tissue sarcoma
(Journal article; Peer reviewed, 2021)Checkpoint inhibitors are slowly being introduced in the care of specific sarcoma subtypes such as undifferentiated pleomorphic sarcoma, alveolar soft part sarcoma, and angiosarcoma even though formal indication is lacking. ... -
Short and long-term effects of single and multiple sessions of electroconvulsive therapy on brain gray matter volumes
(Journal article; Peer reviewed, 2021)Background: Electroconvulsive therapy (ECT) has been shown to induce broadly distributed cortical and subcortical volume increases, more prominently in the amygdala and the hippocampus. Structural changes after one ECT ... -
Distinct Mitochondrial Remodeling During Mesoderm Differentiation in a Human-Based Stem Cell Model
(Journal article; Peer reviewed, 2021-10-14)Given the considerable interest in using stem cells for modeling and treating disease, it is essential to understand what regulates self-renewal and differentiation. Remodeling of mitochondria and metabolism, with the shift ... -
Intestinal Ultrasound to Assess Disease Activity in Ulcerative Colitis: Development of a novel UC-Ultrasound Index
(Journal article; Peer reviewed, 2021)Introduction: Intestinal ultrasound [IUS] is useful to assess inflammation in ulcerative colitis [UC] patients. We aimed to develop an ultrasonographic activity index using endoscopy as the reference standard. Methods: ...
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