Department of Clinical Medicine
Recent Submissions
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Multiple sclerosis -the impact of environmental- and lifestyle factors
(Doctoral thesis, 2021-04-15)Background: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS), likely caused by an interaction of genetic and environmental factors. Epstein-Barr virus infection, low serum ... -
Jodkokeboka
(Book, 2021) -
Is There a Trojan Horse to Aggressive Pancreatic Cancer Biology? A Review of the Trypsin-PAR2 Axis to Proliferation, Early Invasion, and Metastasis
(Journal article; Peer reviewed, 2020)Purpose: Pancreatic cancer is one of the most lethal of solid tumors and is associated with aggressive cancer biology. The purpose is to review the role of trypsin and effect on molecular and cellular processes potentially ... -
Exploring the effects of lifestyle on breast cancer risk, age at diagnosis, and survival: the EBBA-Life study
(Journal article; Peer reviewed, 2020)Purpose Whether an unfavorable lifestyle not only affects breast cancer risk, but also influences age at onset of breast cancer and survival, is under debate. Methods In a population-based cohort, the Energy Balance ... -
Hoftelidelser hos barn og unge- utredning og behandling av senfølger.
(Journal article; Peer reviewed, 2020) -
Evaluation of nutritional status and methods to identify nutritional risk in rheumatoid arthritis and spondyloarthritis
(Journal article; Peer reviewed, 2020-11-21)Patients with rheumatoid arthritis (RA) and spondyloarthritis (SpA) experience several nutritional challenges and are prone to develop malnutrition. This observational study aimed to perform a comprehensive nutritional ... -
MRPS23 amplification and gene expression in breast cancer; association with proliferation and the non-basal subtypes
(Journal article; Peer reviewed, 2020-01-16)Purpose MRPS23 is recognized as a driver of proliferation in luminal breast cancer. The aims of the present study were to describe MRPS23 copy number change in breast cancer, and to assess associations between MRPS23 copy ... -
Interictal epileptiform discharges vary across age groups
(Journal article; Peer reviewed, 2020-01)Objective To investigate whether the occurrence and morphology of interictal epileptiform discharges (IEDs) in scalp-EEG change by age. Methods 10,547 patients who had a standard or sleep deprived EEG recording reported ... -
Multidisciplinary intervention versus brief intervention in specialist healthcare. Attempting to improve outcomes for patients on sick leave with musculoskeletal pain
(Doctoral thesis, 2018-12-11)Background: Musculoskeletal pain (MSK), such as low back pain (LBP), neck pain and widespread pain, is among the most common health problems in industrial countries. Subsequently, MSK is associated with substantial healthcare ... -
Do direct oral anticoagulants (DOACs) cause delayed surgery, longer length of hospital stay, and poorer outcome for hip fracture patients?
(Journal article; Peer reviewed, 2020)Purpose The perioperative consequences of direct oral anticoagulants (DOACs) in hip fracture patients are not sufficiently investigated. The primary aim of this study was to determine whether DOAC-users have delayed surgery ... -
Predictors of chronic pain and level of physical function in total knee arthroplasty: a protocol for a systematic review and meta-analysis
(Journal article; Peer reviewed, 2020)Introduction: One in five patients undergoing total knee arthroplasty (TKA) experience unchanged or worse pain and physical function 1 year after surgery. Identifying risk factors for unfavourable outcomes is necessary to ... -
Quality of life, functional status and cost-effectiveness of treatment after femoral shaft fractures in Malawi. A comparison of skeletal traction and intramedullary nailing in a low resource setting.
(Doctoral thesis, 2021-03-26)Introduction: The incidence of femoral shaft fractures in Low- and Middle-Income Countries(LMICs) ranges from 15.7 to 45.5 per 100,000 people per year. A recent study in Malawi, a low-income country (LIC), estimated the ... -
Outcome at 1 year in patients with femoral shaft fractures treated with intramedullary nailing or skeletal traction in a low-income country: a prospective observational study of 187 patients in Malawi
(Journal article; Peer reviewed, 2020)Background and purpose — Intramedullary nailing (IMN) is underutilized in low-income countries (LICs) where skeletal traction (ST) remains the standard of care for femoral shaft fractures. This prospective study compared ... -
Computerized navigation: A useful tool in total knee replacement.
(Journal article; Peer reviewed, 2020)Background: The purpose of computer assistance in a total knee replacement is to achieve optimal alignment, size, and positioning of the implant. The method is safe and accurate and may be particularly useful in cases ... -
Supplementation with cod protein hydrolysate : Intervention studies in healthy adults and adults with metabolic syndrome
(Doctoral thesis, 2021-03-26)Background: Metabolic syndrome (MetS) is a cluster of metabolic disturbances, including hyperglycaemia, hypertension, dyslipidaemia and abdominal obesity, increasing the risk of non-communicable diseases, such as cardiovascular ... -
Dose Constraints for important Organs at Risk in the Head and Neck Region for Carbon Ion Radiotherapy optimized with the Local Effect Model I (LEM I)
(Doctoral thesis, 2021-03-25)Carbon ion radiotherapy (CIRT) exhibits higher relative biological effectiveness (RBE), compared to photon and proton RT. However, there are substantial uncertainties regarding the clinical RBE of carbon ions. Therefore, ... -
Supplementation with Low Doses of a Cod Protein Hydrolysate on Glucose Regulation and Lipid Metabolism in Adults with Metabolic Syndrome: A Randomized, Double-Blind Study
(Journal article; Peer reviewed, 2020)The risk of cardiovascular diseases and type 2 diabetes mellitus are increased in subjects with metabolic syndrome (MetS), and hydrolyzed fish protein may have favorable effects on metabolic health. Here, we investigated ... -
Whole-Volume Tumor MRI Radiomics for Prognostic Modeling in Endometrial Cancer
(Journal article; Peer reviewed, 2021)Background In endometrial cancer (EC), preoperative pelvic MRI is recommended for local staging, while final tumor stage and grade are established by surgery and pathology. MRI‐based radiomic tumor profiling may aid in ... -
Low birthweight is associated with lower glomerular filtration rate in middle-aged mainly healthy women
(Journal article; Peer reviewed, 2020)Background Low birthweight (LBW) has been shown to increase the risk of severe kidney disease. Studies have also shown associations between LBW and lower estimated glomerular filtration rate (GFR) in young adults. In this ... -
The effect of supplementation with low doses of a cod protein hydrolysate on satiety hormones and inflammatory biomarkers in adults with metabolic syndrome: A randomized, double-blind study
(Journal article; Peer reviewed, 2020-11)Metabolic syndrome (MetS) is characterised by metabolic abnormalities that increase the risk of developing type 2 diabetes mellitus and cardiovascular disease. Altered levels of circulating ghrelin, several adipokines and ...
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