Department of Clinical Medicine
Recent Submissions
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Do patients with lumbar spinal stenosis benefit from decompression of levels with adjacent moderate stenosis? A prospective cohort study from the NORDSTEN study
(Journal article; Peer reviewed, 2024)Background Lumbar spinal stenosis (LSS) is characterized by pain that radiates to the buttocks and/or legs, aggravated by walking and relieved by forward flexion. There is poor correlation between clinical symptoms and ... -
Risk factors and evolution of weight loss in Parkinson's disease: A 9-year population-based study
(Journal article; Peer reviewed, 2024)Introduction: Weight loss is considered a common complication of Parkinson's disease (PD), but there are few prospective longitudinal studies on weight loss in patients followed from time of PD diagnosis. We sought to ... -
Refractory and super-refractory status epilepticus in children and adolescents: A population-based study
(Journal article; Peer reviewed, 2024)Purpose Refractory (RSE) and super-refractory status epilepticus (SRSE) are serious medical emergencies whose long-term outcomes depend on the timeliness of their management. Population-based clinical and epidemiological ... -
Host-gut microbiota interactions shape parasite infections in farmed Atlantic salmon
(Journal article; Peer reviewed, 2024)Animals and their associated microbiota share long evolutionary histories. However, it is not always clear how host genotype and microbiota interact to affect phenotype. We applied a hologenomic approach to explore how ... -
Use of peripherally inserted central venous catheters and midline catheters for palliative care in patients with cancer: a systematic review
(Journal article; Peer reviewed, 2024)Background: Peripherally inserted central catheters (PICCs) and midline catheters (MCs) may offer convenient intravenous access, but evidence to support their place in palliative care is limited. This review aimed to assess ... -
The Prognostic Value of Human Papillomavirus Status in Penile Cancer: Outcomes From a Norwegian Cohort Study
(Journal article; Peer reviewed, 2024)Introduction: Penile squamous cell carcinoma (PSCC) can develop from human papillomavirus (HPV) infection. This study investigates if the prognostic value of the TNM stage groups or the components tumor stage (pT), grade ... -
Walking and balance in older adults with age-related hearing loss: A cross-sectional study of cases and matched controls
(Journal article; Peer reviewed, 2024)Background: Hearing loss (HL) is prevalent in older individuals. It is suggested that there is an association between age-related HL, walking and balance, leading to poorer function and increased risk of falls in older ... -
Brain Proteome Profiling Reveals Common and Divergent Signatures in Parkinson’s Disease, Multiple System Atrophy, and Progressive Supranuclear Palsy
(Journal article; Peer reviewed, 2024)The molecular pathogenesis of degenerative parkinsonisms, including Parkinson’s disease (PD), progressive supranuclear palsy (PSP), and Multiple system atrophy (MSA), remains largely unknown. To gain novel insight into ... -
Emerging Trends in AI and Radiomics for Bladder, Kidney, and Prostate Cancer: A Critical Review
(Journal article; Peer reviewed, 2024)This comprehensive review critically examines the transformative impact of artificial intelligence (AI) and radiomics in the diagnosis, prognosis, and management of bladder, kidney, and prostate cancers. These cutting-edge ... -
Does the use of surgical face masks reduce postoperative infections in traumatic wounds sutured outside hospital? A randomized study at a Norwegian casualty center
(Journal article; Peer reviewed, 2024)Objective To investigate if wearing surgical face mask by doctors and nurses during suturing of traumatic wounds has any impact on postoperative infection rate. Design Randomized controlled study with masked or ... -
Unmasking Patient Diversity: Exploring Cognitive and Antidepressive Effects of Electroconvulsive Therapy
(Journal article; Peer reviewed, 2024)Background Electroconvulsive therapy (ECT) is an established treatment for depression, but more data on effectiveness and safety in clinical practice is needed. The aim of this register-based study was to investigate ... -
Clinical characteristics and factors affecting disease severity in hospitalized tick-borne encephalitis patients in Norway from 2018 to 2022
(Journal article; Peer reviewed, 2024)Purpose To describe the clinical characteristics and factors associated with disease severity in a Norwegian cohort of hospitalized patients with tick-borne encephalitis (TBE). Methods This observational multicenter study ... -
Age-related phenotypes in breast cancer: A population-based study
(Journal article; Peer reviewed, 2024)Breast cancer in young (<40 years) is associated with a higher frequency of aggressive tumor types and poor prognosis. It remains unclear if there is an underlying age-related biology that contributes to the unfavorable ... -
Outcomes and considerations for retrograde intrarenal surgery (RIRS) in the setting of multiple and large renal stones (>15 mm) in children: Findings from multicentre and real-world setting
(Journal article; Peer reviewed, 2024)Purpose The aim of this study is to evaluate the outcomes of retrograde intra renal surgery (RIRS) in the setting of large or multiple stones in children (<18 years). Materials and Methods Retrospective analysis was ... -
Altered exosomal miRNA profiles in patients with paraneoplastic cerebellar degeneration
(Journal article; Peer reviewed, 2024)Objective Patients with ovarian cancer (OC) may develop anti-Yo-associated paraneoplastic cerebellar degeneration (PCD)—a cerebellar ataxia associated with tumor-induced autoimmunity against CDR2 and CDR2L proteins. ... -
Is self-screening for 'at risk of malnutrition' feasible in a home setting?
(Journal article; Peer reviewed, 2024)Introduction Despite malnutrition being established as a well-known risk for postoperative complications, the lack of screening for nutritional risk remains a challenge. The aim of this study was to investigate whether ... -
Genetics of hip dysplasia - a systematic literature review
(Journal article; Peer reviewed, 2024)Background Developmental dysplasia of the hip (DDH) is a congenital condition affecting 2–3% of all newborns. DDH increases the risk of osteoarthritis and is the cause of 30% of all total hip arthroplasties in adults < 40 ... -
The incidence of fractures in children under two years of age: a systematic review
(Journal article; Peer reviewed, 2024)Background Epidemiological research on fractures in children under the age of two is of great importance to help understand differences between accidental and abusive trauma. Objective This systematic review aimed ... -
Effect of pharmacological treatment of attention-deficit/hyperactivity disorder on later psychiatric comorbidity: a population-based prospective long-term study
(Journal article; Peer reviewed, 2024)Background Psychiatric comorbidity is frequent among persons with attention-deficit/hyperactivity disorder (ADHD). Whether pharmacological treatment of ADHD influences the incidence of psychiatric comorbidity is ... -
Mitochondrial complex I deficiency stratifies idiopathic Parkinson’s disease
(Journal article; Peer reviewed, 2024)Idiopathic Parkinson’s disease (iPD) is believed to have a heterogeneous pathophysiology, but molecular disease subtypes have not been identified. Here, we show that iPD can be stratified according to the severity of ...