• Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores 

  de Rojas, Itziar; Moreno-Grau, Sonia; Tesi, Niccolo; Grenier-Boley, Benjamin; Andrade, Victor; Jansen, Iris E.; Rongve, Arvid; Aarsland, Dag; Selbæk, Geir; Saltvedt, Ingvild; Sando, Sigrid Botne; Djurovic, Srdjan; Andreassen, Ole; Pedersen, Nancy L.; Stringa, Najada; Zettergren, Anna; Hernández, Isabel; Montrreal, Laura; Antunez, Carmen; Antonell, Anna; Tankard, Rick; Bis, Joshua C.; Sims, Rebecca; Bellenguez, Celine; Quintela, Inés; González-Pérez, Antonio; Calero, Miguel; Franco-Macias, Emilio; Macias, Juan; Blesa, Rafael; Cervera-Carles, Laura; Menendez-Gonzalez, Manuel; Frank-Garcia, Ana; Royo, José Luis; Moreno, Fermin; Vilas, Raquel Huerto; Baquero, Miquel; Diez-Fairen, Monica; Lage, Carmen; García-Madrona, Sebastian; Garcia-Gonzalez, Pablo; Alarcón-Martín, Emilio; Valero, Sergi; Sotolongo-Grau, Oscar; Ullgren, Abbe; Naj, Adam C.; Lemstra, Afina W.; Benaque, Alba; Perez-Cordon, Alba; Benussi, Alberto; Rabano, Alberto (Journal article; Peer reviewed, 2021)

  Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical ...

• Clinical responses following inspiratory muscle training in exercise-induced laryngeal obstruction 

  Sandnes, Astrid; Andersen, Tiina Maarit; Clemm, Hege Synnøve Havstad; Hilland, Magnus; Heimdal, John-Helge; Halvorsen, Thomas; Røksund, Ola Drange; Vollsæter, Maria (Journal article; Peer reviewed, 2021)

  Purpose Exercise-induced laryngeal obstruction (EILO) is relatively common in young people. Treatment rests on poor evidence; however, inspiratory muscle training (IMT) has been proposed a promising strategy. We aimed to ...

• CSF neurofilament light chain predicts 10-year clinical and radiologic worsening in multiple sclerosis 

  Bhan, Alok; Jacobsen, Cecilie; Dalen, Ingvild; Bergsland, Niels; Zivadinov, Robert; Alves, Guido Werner; Myhr, Kjell-Morten; Farbu, Elisabeth (Journal article; Peer reviewed, 2021)

  Background Neurofilament light chain (NfL) is an attractive biomarker of disease activity and progression in MS, but there is a lack in long-term prognostic data. Objective To test the long-term clinical and radiological ...

• Prevalence of patients “at risk of malnutrition” and nutritional routines among surgical and non-surgical patients at a large university hospital during the years 2008–2018 

  Skeie, Eli; Sygnestveit, Kari; Nilsen, Roy M.; Harthug, Stig; Koch, Anne Mette; Tangvik, Randi Julie (Journal article; Peer reviewed, 2021)

  Background & aims: Being “at risk of malnutrition”, which includes both malnutrition and the risk to be so, is associated with increased morbidity and mortality in both surgical and non-surgical patients. Several strategies ...

• Increased risk of hospitalisation and intensive care admission associated with reported cases of SARS-CoV-2 variants B.1.1.7 and B.1.351 in Norway, December 2020-May 2021 

  Veneti, Lamprini; Seppälä, Elina Marjukka; Storm, Margrethe Larsdatter; Valcarcel Salamanca, Beatriz; Buanes, Eirik Alnes; Aasand, Nina Therese; Naseer, Mohammed Umaer; Bragstad, Karoline; Hungnes, Olav; Bøås, Håkon; Kvåle, Reidar; Samareh Golestani, Karan; Feruglio, Siri Laura; Vold, Line; Nygård, Karin Maria; Whittaker, Robert Neil (Journal article; Peer reviewed, 2021)

  Introduction Since their emergence, SARS-CoV-2 variants of concern (VOC) B.1.1.7 and B.1.351 have spread worldwide. We estimated the risk of hospitalisation and admission to an intensive care unit (ICU) for infections ...

• Use of quantitative pathology to improve grading and predict prognosis in tumours of the gastrointestinal tract 

  Lea, Dordi (Doctoral thesis, 2022-01-14)

  Cancer represents a formidable health burden and was the second leading cause of death globally in 2018. In Norway, almost 35000 new cancer cases were reported in 2019. For colon cancer, the incidence and mortality rates ...

• Current status of thulium fibre laser lithotripsy: an up-to-date review 

  Jones, Patrick; Beisland, Christian; Ulvik, Øyvind (Journal article; Peer reviewed, 2021)

  Objective To perform an up-to-date review to scope the current status of the thulium fibre laser (TFL) in the setting of stone lithotripsy and provide a guide for the clinical urologist. Methods A review of world ...

• How Does Implant Survivorship Vary with Different Corail Femoral Stem Variants? Results of 51,212 Cases with Up to 30 Years Of Follow-up from the Norwegian Arthroplasty Register 

  Melbye, Silje Marie; Haug, Sofie Cecilia Dietrich; Fenstad, Anne Marie; Furnes, Ove Nord; Gjertsen, Jan-Erik; Hallan, Geir (Journal article; Peer reviewed, 2021)

  Background: The Corail® cementless stem (DePuy Synthes) has been used in Norway since 1987 and is one of the most frequently used stems in THA worldwide. Although the published survival results of the standard Corail stem ...

• Variable expression of eighteen common housekeeping genes in human non-cancerous kidney biopsies 

  Strauss, Philipp; Furriol, Jessica; mikkelsen, Håvard (Journal article; Peer reviewed, 2021)

  Housekeeping, or reference genes (RGs) are, by definition, loci with stable expression profiles that are widely used as internal controls to normalize mRNA levels. However, due to specific events, such as pathological ...

• Gastrointestinal transit and contractility in diabetic constipation: A wireless motility capsule study on diabetes patients and healthy controls 

  Sangnes, Dag A.; Lundervold, Katarina; Bekkelund, Mattis; Volkmann, Hilde Løland Von; Berentsen, Birgitte; Gilja, Odd Helge; Dimcevski, Georg; Søfteland, Eirik (Journal article; Peer reviewed, 2021)

  Background: Diabetic constipation is traditionally attributed to slow colonic transit, despite limited evidence. More than half of patients find treatment unsatisfactory. To improve treatment, there is a need for better ...

• ILIVE Project Volunteer study. Developing international consensus for a European Core Curriculum for hospital end-of-life-care volunteer services, to train volunteers to support patients in the last weeks of life: A Delphi study 

  McGlinchey, Tamsin; Mason, Stephen R; Smeding, Ruthmarijke; Goosensen, Anne; Ruiz-Torreras, Inmaculada; Haugen, Dagny Renata Faksvåg; Bakan, Miša; Ellershaw, John E (Journal article; Peer reviewed, 2021)

  Background: Volunteers make a huge contribution to the health and wellbeing of the population and can improve satisfaction with care especially in the hospice setting. However, palliative and end-of-life-care volunteer ...

• Management and outcomes in critically ill nonagenarian versus octogenarian patients 

  Bruno, Raphael Romano; Wernly, Bernhard; Kelm, Malte; Boumendil, Ariane; Morandi, Alessandro; Andersen, Finn H.; Artigas, Antonio; Finazzi, Stefano; Cecconi, Maurizio; Christensen, Steffen; Faraldi, Loredana; Lichtenauer, Michael; Flaatten, Hans; Jung, Christian (Journal article; Peer reviewed, 2021)

  Background: Intensive care unit (ICU) patients age 90 years or older represent a growing subgroup and place a huge financial burden on health care resources despite the benefit being unclear. This leads to ethical problems. ...

• EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1 

  Ando, Toshinori; Arang, Nadia; Wang, Zhiyong; Costea, Daniela Elena; Feng, Xiaodong; Goto, Yusuke; Izumi, Hiroki; Gilardi, Mara; Ando, Kazuyo; Gutkind, J. Silvio (Journal article; Peer reviewed, 2021)

  The Hippo pathway is frequently dysregulated in cancer, leading to the unrestrained activity of its downstream targets, YAP/TAZ, and aberrant tumor growth. However, the precise mechanisms leading to YAP/TAZ activation in ...

• Polyvinylpyrrolidone deposition disease in patients with intravenous opioid use: a case series 

  Leh, Friedemann; Stalund, Ida Viken; Bjånes, Tormod Karlsen; Ohldieck, Christian; Svarstad, Einar; Leh, Sabine (Journal article; Peer reviewed, 2021)

  The polymer polyvinylpyrrolidone (PVP) is an excipient widely used in prescription drugs. Depending on the molecular weight (MW), parenterally administered PVP may accumulate in various tissues. Consequently, moderate and ...

• Differences in mortality in critically ill elderly patients during the second COVID‑19 surge in Europe 

  Jung, Christian; Fjølner, Jesper; Bruno, Raphael Romano; Wernly, Bernhard; Artigas, Antonio; Pinto, Bernardo Bollen; Schefold, Joerg C.; Wolf, Georg; Kelm, Malte; Beil, Michael; Sviri, Sigal; van Heerden, Peter Vernon; Szczeklik, Wojciech; Czuczwar, Miroslaw; Joannidis, Michael; Oeyen, Sandra; Zafeiridis, Tilemachos; Andersen, Finn H.; Moreno, Rui; Leaver, Susannah; Boumendil, Ariane; De Lange, Dylan W.; Guidet, Bertrand; Flaatten, Hans (Journal article; Peer reviewed, 2021)

  Background: The primary aim of this study was to assess the outcome of elderly intensive care unit (ICU) patients treated during the spring and autumn COVID-19 surges in Europe. Methods: This was a prospective European ...

• Relationship between the Clinical Frailty Scale and short‑term mortality in patients ≥ 80 years old acutely admitted to the ICU: a prospective cohort study. 

  Fronczek, Jakub; Polok, Kamil; de Lange, Dylan W.; Jung, Christian; Beil, Michael; Rhodes, Andrew; Fjølner, Jesper; Górka, Jacek; Andersen, Finn H.; Artigas, Antonio; Cecconi, Maurizio; Christensen, Steffen; Flaatten, Hans; Szczeklik, Wojciech (Journal article; Peer reviewed, 2021)

  Background: The Clinical Frailty Scale (CFS) is frequently used to measure frailty in critically ill adults. There is wide variation in the approach to analysing the relationship between the CFS score and mortality after ...

• Quality of life among women with symptomatic, screen-detected, and interval breast cancer, and for women without breast cancer: a retrospective cross-sectional study from Norway 

  Moshina, Nataliia; Falk, Ragnhild Sørum; Botteri, Edoardo; Larsen, Marthe; Akslen, Lars Andreas; Cairns, John Alexander; Hofvind, Solveig (Journal article; Peer reviewed, 2021)

  Purpose: Breast cancers detected at screening need less aggressive treatment compared to breast cancers detected due to symptoms. The evidence on the quality of life associated with screen-detected versus symptomatic breast ...

• Re-evaluation of medical findings in alleged shaken baby syndrome and abusive head trauma in Norwegian courts fails to support abuse diagnoses 

  Wester, Knut Gustav; Stridbeck, Ulf; Syse, Aslak; Wikström, Johan (Journal article; Peer reviewed, 2021)

  Aim: The criteria for diagnosing abusive head trauma (AHT) are not well defined and this condition might be diagnosed on failing premises. Our aim was to review criminal AHT cases in Norwegian courts by scrutinising the ...

• Clinical and MRI findings in lumbar spinal stenosis: baseline data from the NORDSTEN study 

  Aaen, Jørn; Austevoll, Ivar Magne; Hellum, Christian; Storheim, Kjersti; Myklebust, Tor Åge; Banitalebi, Hasan; Anvar, Masoud; Brox, Jens Ivar; Weber, Clemens; Solberg, Tore; Grundnes, Oliver; Brisby, Helena; Indrekvam, Kari; Hermansen, Erland (Journal article; Peer reviewed, 2021)

  Purpose: The aim was to describe magnetic resonance imaging findings in patients planned for lumbar spinal stenosis surgery. Further, to describe possible associations between MRI findings and patient characteristics with ...

• Accuracy of single intravenous access iohexol GFR in children is hampered by marker contamination 

  Eide, Thea Tislevoll; Hufthammer, Karl Ove; Brun, Atle; Brackman, Damien; Svarstad, Einar; Tøndel, Camilla (Journal article; Peer reviewed, 2021)

  Measurement of glomerular filtration rate (GFR) in children by iohexol injection and blood sampling from the contralateral arm is widely used. A single intravenous access for iohexol injection and subsequent blood sampling ...

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