• Elderly Patients With No Previous Psychiatric History: Suicidality and Other Factors Relating to Psychiatric Acute Admissions 

  Lund-Heimark, Hallvard; Kjelby, Eirik; Mehlum, Lars; Gjestad, Rolf; Selbæk, Geir; Kroken, Rune Andreas; Johnsen, Erik; Ødegaard, Ketil Joachim; Mellesdal, Liv Solrunn (Journal article; Peer reviewed, 2020)

  Background: The common recommendation that adults with onset of mental illness after the age of 65 should receive specialised psychogeriatric treatment is based on limited evidence. Aims: To compare factors related to ...

• Myasthenia gravis can have consequences for pregnancy and the developing child 

  Gilhus, Nils Erik (Journal article; Peer reviewed, 2020)

  Myasthenia gravis (MG) with onset below 50 years, thymic hyperplasia and acetylcholine receptor (AChR) antibodies is more common in females than in males. For a relatively large group of MG patients, pregnancy represents ...

• Teriflunomide vs injectable disease modifying therapies for relapsing forms of MS 

  Vermersch, Patrick; Oh, Jiwon; Cascione, Mark; Oreja-Guevara, Celia; Gobbi, Claudio; Travis, Lori H.; Myhr, Kjell-Morten; Coyle, Patricia K. (Journal article; Peer reviewed, 2020)

  Multiple sclerosis (MS) is a chronic, immune-mediated, inflammatory disease affecting the white and gray matter of the central nervous system. Several disease modifying therapies (DMTs) have been shown to significantly ...

• The changing landscape of Fabry disease 

  Svarstad, Einar; Marti, Hans-Peter (Journal article; Peer reviewed, 2020)

• Possible role of intestinal stem cells in the pathophysiology of irritable bowel syndrome 

  El-Salhy, Magdy (Journal article; Peer reviewed, 2020)

  The pathophysiology of irritable bowel syndrome (IBS) is not completely understood. However, several factors are known to play a role in pathophysiology of IBS such as genetics, diet, gut microbiota, gut endocrine cells, ...

• Accumulation of Globotriaosylceramide in Podocytes in Fabry Nephropathy Is Associated with Progressive Podocyte Loss 

  Najafian, Behzad; Tøndel, Camilla; Svarstad, Einar; Gubler, Marie-Claire; Oliveira, Joao-Paulo; Mauer, Michael (Journal article; Peer reviewed, 2020)

  Background In males with classic Fabry disease, the processes leading to the frequent outcome of ESKD are poorly understood. Defects in the gene encoding α-galactosidase A lead to accumulation of globotriaosylceramide (GL3) ...

• The Cognitive Profile of Mild Cognitive Impairment Due to Dementia With Lewy Bodies—An Updated Review 

  Hemminghyth, Mathilde Suhr; Chwiszczuk, Luiza; Rongve, Arvid; Breitve, Monica Haraldseid (Journal article; Peer reviewed, 2020)

  Objective: Dementia with Lewy Bodies (DLB) is the second most common type of neurodegenerative dementia. Yet, the domain-specific cognitive impairment of the mild cognitive impairment (MCI) phase of this disease (DLB-MCI) ...

• Variability in functional outcome and treatment practices by treatment center after out-of-hospital cardiac arrest: analysis of International Cardiac Arrest Registry 

  May, Teresa L.; Lary, Christine W.; Riker, Richard R.; Friberg, Hans; Patel, Nainesh; Søreide, Eldar; McPherson, John A.; Undén, Johan; Hand, Robert; Sunde, Kjetil; Stammet, Pascal; Rubertsson, Stein; Belohlvaek, Jan; Dupont, Allison; Hirsch, Karen G.; Valsson, Felix; Kern, Karl; Sadaka, Farid; Israelsson, Johan; Dankiewicz, Josef; Nielsen, Niklas; Seder, David B.; Agarwal, Sachin (Journal article; Peer reviewed, 2019)

  Purpose Functional outcomes vary between centers after out-of-hospital cardiac arrest (OHCA) and are partially explained by pre-existing health status and arrest characteristics, while the effects of in-hospital treatments ...

• A combined histo-score based on tumor differentiation and lymphocytic infiltrate is a robust prognostic marker for mobile tongue cancer 

  Bjerkli, Inger-Heidi; Hadler-Olsen, Elin Synnøve; Nginamau, Elisabeth Sivy; Laurvik, Helene; Søland, Tine Merete; Costea, Daniela Elena; Uhlin-Hansen, Lars; Steigen, Sonja Eriksson (Journal article; Peer reviewed, 2020-06-30)

  We wanted to evaluate the prognostic value of common histopathological variables in a large cohort of patients with cancer in the mobile tongue as such information can be important for treatment stratification of the ...

• Operating room ventilation and the risk of revision due to infection after total hip arthroplasty: assessment of validated data in the Norwegian Arthroplasty Register 

  Langvatn, Håkon; Schrama, Johannes Cornelis; Cao, Guangyu; Hallan, Geir; Furnes, Ove; Lingass, Egil; Walenkamp, Geert; Engesæter, Lars Birger; Dale, Håvard (Journal article; Peer reviewed, 2020)

  Background The air in the operating room is considered a risk factor for surgical site infection (SSI) due to airborne bacteria shed from the surgical staff or from patients themselves. Aim To assess the influence of ...

• AChR antibodies show a complex interaction with human skeletal muscle cells in a transcriptomic study 

  Hong, Yu; Liang, Kristina Xiao; Gilhus, Nils Erik (Journal article; Peer reviewed, 2020-07-08)

  Acetylcholine receptor (AChR) antibodies are the most important pathogenic marker in patients with myasthenia gravis (MG). The antibodies bind to AChRs on the postsynaptic membrane, and this leads to receptor degradation, ...

• Wearing-off at the end of natalizumab dosing intervals is associated with low receptor occupancy 

  Bringeland, Gerd Haga; Blaser, Nello; Myhr, Kjell-Morten; Vedeler, Christian A.; Gavasso, Sonia (Journal article; Peer reviewed, 2020-02)

  Objective: We aimed to investigate whether wearing-off symptoms at the end of the natalizumab dosing interval were associated with clinical and demographic patient characteristics or natalizumab receptor occupancy (RO) on ...

• Functional evaluation of 16 SCHAD missense variants: Only amino acid substitutions causing congenital hyperinsulinism of infancy lead to loss-of-function phenotypes in vitro 

  Velasco Pinto, Kelly; St-Louis, Johanna; Hovland, Henrikke N.; Thompson, Nels; Ottesen, Åsta; Choi, Man Hung; Pedersen, Line; Njølstad, Pål Rasmus; Arnesen, Thomas; Fjeld, Karianne; Aukrust, Ingvild; Myklebust, Line Merethe; Molven, Anders (Journal article; Peer reviewed, 2021)

  Short‐chain 3‐hydroxyacyl‐CoA dehydrogenase (SCHAD), encoded by the HADH gene, is a ubiquitously expressed mitochondrial enzyme involved in fatty acid oxidation. This protein also plays a role in insulin secretion as ...

• Functional and animal studies of short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD), a fatty acid beta-oxidation enzyme involved in congenital hyperinsulinism of infancy 

  St-Louis, Johanna (Doctoral thesis, 2021-02-16)

  Short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD) is a mitochondrial enzyme involved in fatty acid β-oxidation and the regulation of β-cell insulin secretion. Its role in insulin secretion became apparent in 2001 when ...

• Benign paroxysmal positional vertigo and treatment in biaxial rotational chair 

  Martens, Camilla (Doctoral thesis, 2021-04-23)

  Benign paroxysmal positional vertigo (BPPV) is the most common cause of peripheral dizziness. The overall aim of this thesis was to examine a new standardised intervention-tool to provide a better treatment for patients ...

• Stem cell function is conserved during shortterm storage of cultured epidermal cell sheets at 12˚C 

  Ringstad, Håkon; Reppe, Sjur; Schøyen, Tine Hiorth; Tønseth, Kim Alexander; Utheim, Tor Paaske; Jackson, Catherine (Journal article; Peer reviewed, 2020)

  Transplantation of cultured epidermal cell sheets (CES) can be life-saving for patients with large area burns. CES have also been successfully used to regenerate eye and urethral epithelia in animal models. Short-term ...

• Treatment of horizontal canal BPPV—a randomized sham-controlled trial comparing two therapeutic maneuvers of different speeds 

  Martens, Camilla; Goplen, Frederik Kragerud; Aasen, Torbjørn; Gjestad, Rolf; Nordfalk, Karl Fredrik; Nordahl, Stein Helge Glad (Journal article; Peer reviewed, 2020)

  Objectives: To compare the effect of a high‐speed barbecue maneuver with the modified Lempert maneuver and sham in patients with benign paroxysmal positional vertigo (BPPV) of the horizontal canal. Methods: Randomized ...

• Oxidative Stress in the Pathophysiology of Kidney Disease: Implications for Noninvasive Monitoring and Identification of Biomarkers 

  Gyurászová, Marianna; Gurecká, Radana; Babickova, Janka; Tóthová, Ľubomíra (Journal article; Peer reviewed, 2020)

  Kidney disease represents a serious global health problem. One of the main concerns is its late diagnosis, only feasible in a progressed disease state. The lack of a clinical manifestation in the early stages and the fact ...

• Feasibility and acceptability of introducing advance care planning on a thoracic medicine inpatient ward: an exploratory mixed method study 

  Hjorth, Nina Elisabeth; Schaufel, Margrethe Aase; Sigurdardottir, Katrin Rut; Haugen, Dagny Faksvåg (Journal article; Peer reviewed, 2020)

  Background and aims Advance care planning (ACP) is communication about wishes and preferences for end-of-life care. ACP is not routinely used in any Norwegian hospitals. We performed a pilot study (2014–2017) introducing ...

• Factors affecting quality of end-of-life hospital care - a qualitative analysis of free text comments from the i-CODE survey in Norway 

  Hansen, Marit Irene Tuen; Haugen, Dagny Faksvåg; Sigurdardottir, Katrin Rut; Kvikstad, Anne; Mayland, Catriona Rachel; Schaufel, Margrethe Aase (Journal article; Peer reviewed, 2020)

  Background The ERANet-LAC CODE (Care Of the Dying Evaluation) international survey assessed quality of care for dying cancer patients in seven countries, by use of the i-CODE questionnaire completed by bereaved relatives. ...

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