• Use of quantitative pathology to improve grading and predict prognosis in tumours of the gastrointestinal tract 

  Lea, Dordi (Doctoral thesis, 2022-01-14)

  Cancer represents a formidable health burden and was the second leading cause of death globally in 2018. In Norway, almost 35000 new cancer cases were reported in 2019. For colon cancer, the incidence and mortality rates ...

• Current status of thulium fibre laser lithotripsy: an up-to-date review 

  Jones, Patrick; Beisland, Christian; Ulvik, Øyvind (Journal article; Peer reviewed, 2021)

  Objective To perform an up-to-date review to scope the current status of the thulium fibre laser (TFL) in the setting of stone lithotripsy and provide a guide for the clinical urologist. Methods A review of world ...

• How Does Implant Survivorship Vary with Different Corail Femoral Stem Variants? Results of 51,212 Cases with Up to 30 Years Of Follow-up from the Norwegian Arthroplasty Register 

  Melbye, Silje Marie; Haug, Sofie Cecilia Dietrich; Fenstad, Anne Marie; Furnes, Ove Nord; Gjertsen, Jan-Erik; Hallan, Geir (Journal article; Peer reviewed, 2021)

  Background: The Corail® cementless stem (DePuy Synthes) has been used in Norway since 1987 and is one of the most frequently used stems in THA worldwide. Although the published survival results of the standard Corail stem ...

• Variable expression of eighteen common housekeeping genes in human non-cancerous kidney biopsies 

  Strauss, Philipp; Furriol, Jessica; mikkelsen, Håvard (Journal article; Peer reviewed, 2021)

  Housekeeping, or reference genes (RGs) are, by definition, loci with stable expression profiles that are widely used as internal controls to normalize mRNA levels. However, due to specific events, such as pathological ...

• Gastrointestinal transit and contractility in diabetic constipation: A wireless motility capsule study on diabetes patients and healthy controls 

  Sangnes, Dag A.; Lundervold, Katarina; Bekkelund, Mattis; Volkmann, Hilde Løland Von; Berentsen, Birgitte; Gilja, Odd Helge; Dimcevski, Georg; Søfteland, Eirik (Journal article; Peer reviewed, 2021)

  Background: Diabetic constipation is traditionally attributed to slow colonic transit, despite limited evidence. More than half of patients find treatment unsatisfactory. To improve treatment, there is a need for better ...

• ILIVE Project Volunteer study. Developing international consensus for a European Core Curriculum for hospital end-of-life-care volunteer services, to train volunteers to support patients in the last weeks of life: A Delphi study 

  McGlinchey, Tamsin; Mason, Stephen R; Smeding, Ruthmarijke; Goosensen, Anne; Ruiz-Torreras, Inmaculada; Haugen, Dagny Renata Faksvåg; Bakan, Miša; Ellershaw, John E (Journal article; Peer reviewed, 2021)

  Background: Volunteers make a huge contribution to the health and wellbeing of the population and can improve satisfaction with care especially in the hospice setting. However, palliative and end-of-life-care volunteer ...

• Management and outcomes in critically ill nonagenarian versus octogenarian patients 

  Bruno, Raphael Romano; Wernly, Bernhard; Kelm, Malte; Boumendil, Ariane; Morandi, Alessandro; Andersen, Finn H.; Artigas, Antonio; Finazzi, Stefano; Cecconi, Maurizio; Christensen, Steffen; Faraldi, Loredana; Lichtenauer, Michael; Flaatten, Hans; Jung, Christian (Journal article; Peer reviewed, 2021)

  Background: Intensive care unit (ICU) patients age 90 years or older represent a growing subgroup and place a huge financial burden on health care resources despite the benefit being unclear. This leads to ethical problems. ...

• EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1 

  Ando, Toshinori; Arang, Nadia; Wang, Zhiyong; Costea, Daniela Elena; Feng, Xiaodong; Goto, Yusuke; Izumi, Hiroki; Gilardi, Mara; Ando, Kazuyo; Gutkind, J. Silvio (Journal article; Peer reviewed, 2021)

  The Hippo pathway is frequently dysregulated in cancer, leading to the unrestrained activity of its downstream targets, YAP/TAZ, and aberrant tumor growth. However, the precise mechanisms leading to YAP/TAZ activation in ...

• Polyvinylpyrrolidone deposition disease in patients with intravenous opioid use: a case series 

  Leh, Friedemann; Stalund, Ida Viken; Bjånes, Tormod Karlsen; Ohldieck, Christian; Svarstad, Einar; Leh, Sabine (Journal article; Peer reviewed, 2021)

  The polymer polyvinylpyrrolidone (PVP) is an excipient widely used in prescription drugs. Depending on the molecular weight (MW), parenterally administered PVP may accumulate in various tissues. Consequently, moderate and ...

• Differences in mortality in critically ill elderly patients during the second COVID‑19 surge in Europe 

  Jung, Christian; Fjølner, Jesper; Bruno, Raphael Romano; Wernly, Bernhard; Artigas, Antonio; Pinto, Bernardo Bollen; Schefold, Joerg C.; Wolf, Georg; Kelm, Malte; Beil, Michael; Sviri, Sigal; van Heerden, Peter Vernon; Szczeklik, Wojciech; Czuczwar, Miroslaw; Joannidis, Michael; Oeyen, Sandra; Zafeiridis, Tilemachos; Andersen, Finn H.; Moreno, Rui; Leaver, Susannah; Boumendil, Ariane; De Lange, Dylan W.; Guidet, Bertrand; Flaatten, Hans (Journal article; Peer reviewed, 2021)

  Background: The primary aim of this study was to assess the outcome of elderly intensive care unit (ICU) patients treated during the spring and autumn COVID-19 surges in Europe. Methods: This was a prospective European ...

• Relationship between the Clinical Frailty Scale and short‑term mortality in patients ≥ 80 years old acutely admitted to the ICU: a prospective cohort study. 

  Fronczek, Jakub; Polok, Kamil; de Lange, Dylan W.; Jung, Christian; Beil, Michael; Rhodes, Andrew; Fjølner, Jesper; Górka, Jacek; Andersen, Finn H.; Artigas, Antonio; Cecconi, Maurizio; Christensen, Steffen; Flaatten, Hans; Szczeklik, Wojciech (Journal article; Peer reviewed, 2021)

  Background: The Clinical Frailty Scale (CFS) is frequently used to measure frailty in critically ill adults. There is wide variation in the approach to analysing the relationship between the CFS score and mortality after ...

• Quality of life among women with symptomatic, screen-detected, and interval breast cancer, and for women without breast cancer: a retrospective cross-sectional study from Norway 

  Moshina, Nataliia; Falk, Ragnhild Sørum; Botteri, Edoardo; Larsen, Marthe; Akslen, Lars Andreas; Cairns, John Alexander; Hofvind, Solveig (Journal article; Peer reviewed, 2021)

  Purpose: Breast cancers detected at screening need less aggressive treatment compared to breast cancers detected due to symptoms. The evidence on the quality of life associated with screen-detected versus symptomatic breast ...

• Re-evaluation of medical findings in alleged shaken baby syndrome and abusive head trauma in Norwegian courts fails to support abuse diagnoses 

  Wester, Knut Gustav; Stridbeck, Ulf; Syse, Aslak; Wikström, Johan (Journal article; Peer reviewed, 2021)

  Aim: The criteria for diagnosing abusive head trauma (AHT) are not well defined and this condition might be diagnosed on failing premises. Our aim was to review criminal AHT cases in Norwegian courts by scrutinising the ...

• Clinical and MRI findings in lumbar spinal stenosis: baseline data from the NORDSTEN study 

  Aaen, Jørn; Austevoll, Ivar Magne; Hellum, Christian; Storheim, Kjersti; Myklebust, Tor Åge; Banitalebi, Hasan; Anvar, Masoud; Brox, Jens Ivar; Weber, Clemens; Solberg, Tore; Grundnes, Oliver; Brisby, Helena; Indrekvam, Kari; Hermansen, Erland (Journal article; Peer reviewed, 2021)

  Purpose: The aim was to describe magnetic resonance imaging findings in patients planned for lumbar spinal stenosis surgery. Further, to describe possible associations between MRI findings and patient characteristics with ...

• Accuracy of single intravenous access iohexol GFR in children is hampered by marker contamination 

  Eide, Thea Tislevoll; Hufthammer, Karl Ove; Brun, Atle; Brackman, Damien; Svarstad, Einar; Tøndel, Camilla (Journal article; Peer reviewed, 2021)

  Measurement of glomerular filtration rate (GFR) in children by iohexol injection and blood sampling from the contralateral arm is widely used. A single intravenous access for iohexol injection and subsequent blood sampling ...

• Chambered warm moist air eyelid warming devices – a review 

  Magno, Morten Schjerven; Olafsson, Jonatan; Beining, Marie; Moschowits, Emily; Lagali, Neil; Wolffsohn, James S.; Craig, Jennifer P.; Dartt, Darlene A.; Vehof, Jelle; Utheim, Tor P. (Journal article; Peer reviewed, 2021)

  Background Eyelid warming is an important treatment for meibomian gland dysfunction (MGD). Specialized chambered devices, using warm moist air have been developed. Purpose To critically evaluate the literature on the ...

• Cancer-related fatigue and treatment burden in surgically treated colorectal cancer patients – A cross-sectional study 

  Husebø, Anne Marie Lunde; Dalen, Ingvild; Søreide, Jon Arne; Bru, Edvin; Richardson, Alison (Journal article; Peer reviewed, 2021)

  Objective This cross-sectional study aimed to describe cancer-related fatigue (CRF) in colorectal cancer (CRC) patients who were surgically treated with curative intent, identify subgroups at risk of elevated fatigue ...

• Childhood trauma, antipsychotic medication, and symptom remission in first-episode psychosis 

  Ottesen, Akiah; Hegelstad, Wenche; Joa, Inge; Ilner, Stein E. Opjordsmoen; Rund, Bjørn Rishovd; Røssberg, Jan Ivar; Simonsen, Erik; Johannessen, Jan Olav; Larsen, Tor Ketil; Haahr, Ulrik H.; McGlashan, T.H.; Friis, Svein; Melle, Ingrid (Journal article; Peer reviewed, 2021)

  Background: To what extent psychotic symptoms in first-episode psychosis (FEP) with a history of childhood interpersonal trauma (CIT) are less responsive to antipsychotic medication is not known. In this longitudinal study, ...

• The association between visual display terminal use and dry eye: a review 

  Fjærvoll, Haakon Kristoffer Olsen; Fjærvoll, Ketil Andreas Olsen; Magnø, Morten Scherven; Moschowits, Emily; Vehof, Jelle; Dartt, Darlene A.; Utheim, Tor Paaske (Journal article; Peer reviewed, 2021)

  Background: Dry eye disease (DED) is a multifactorial disease of the tear film and ocular surface. It causes ocular symptoms, reduced quality of life and a considerable economic burden on society. Prolonged use of visual ...

• Pellino-2 in nonimmune cells: novel interaction partners and intracellular localization 

  Cristea, Ileana; Bruland, Ove; Rødahl, Eyvind; Bredrup, Cecilie (Journal article; Peer reviewed, 2021)

  Pellino-2 is an E3 ubiquitin ligase that mediates intracellular signaling in innate immune pathways. Most studies of endogenous Pellino-2 have been performed in macrophages, but none in nonimmune cells. Using yeast two-hybrid ...

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