Department of Clinical Medicine
Recent Submissions
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Functional delineation of the luminal epithelial microenvironment in breast using cell-based screening in combinatorial microenvironments
(Journal article; Peer reviewed, 2024)Microenvironment signals are potent determinants of cell fate and arbiters of tissue homeostasis, however understanding how different microenvironment factors coordinately regulate cellular phenotype has been experimentally ... -
New, simplified versus standard photodynamic therapy (PDT) regimen for superficial and nodular basal cell carcinoma (BCC): A single-blind, non-inferiority, randomised controlled multicentre study
(Journal article; Peer reviewed, 2024)Background Topical photodynamic therapy (PDT) is an approved and widely used treatment for low-risk basal cell carcinoma (BCC), comprising two sessions with an interval of 1 week. Simplification of the treatment course ... -
Outcomes with the Adjustable Transobturator Male System (ATOMS) for the Treatment of Male Stress Urinary Incontinence After Prostate Surgery and the Impact of Previous Radiotherapy
(Journal article; Peer reviewed, 2024)Background and objective The adjustable transobturator male system (ATOMS) is an established treatment for patients with urinary incontinence after prostate surgery. Our objective was to evaluate the efficacy and the ... -
IC3D Classification of Corneal Dystrophies - Edition 3
(Journal article; Peer reviewed, 2024)Purpose: The International Committee for the Classification of Corneal Dystrophies (IC3D) was created in 2005 to develop a new classification system integrating current information on phenotype, histopathology, and ... -
Promoting cemented fixation of the femoral stem in elderly female hip arthroplasty patients and elderly hip fracture patients: a retrospective cohort study from the Norwegian Arthroplasty Register and the Norwegian Hip Fracture Register
(Journal article; Peer reviewed, 2024)Background and purpose: Uncemented stems increase the risk of revision in elderly patients. In 2018, we initiated a national quality improvement project aiming to increase the proportion of cemented stems in elderly female ... -
An analysis of omega-3 clinical trials and a call for personalized supplementation for dementia prevention
(Journal article; Peer reviewed, 2024)Introduction Targeted interventions are needed to delay or prevent the onset of neurodegenerative diseases. Poor dietary habits are associated with cognitive decline, highlighting the benefits of a healthy diet with ... -
Interplay of mitochondria and diabetes: Unveiling novel therapeutic strategies
(Journal article; Peer reviewed, 2024)The interplay between mitochondrial function and diabetes has gained significant attention due to its crucial role in the pathogenesis and progression of the disease. Mitochondria, known as the cellular powerhouses, are ... -
Generalized myasthenia gravis with acetylcholine receptor antibodies: A guidance for treatment
(Journal article; Peer reviewed, 2024)Background Generalized myasthenia gravis (MG) with antibodies against the acetylcholine receptor is a chronic disease causing muscle weakness. Access to novel treatments warrants authoritative treatment recommendations. ... -
Use of corticosteroids in Norwegian patients with immunoglobulin a nephropathy progressing to end-stage kidney disease: a retrospective cohort study
(Journal article; Peer reviewed, 2024)Background Despite several clinical trials, the use of corticosteroid therapy for treating immunoglobulin A nephropathy (IgAN) remains controversial. We aimed to describe the use of corticosteroid therapy combined with ... -
How good are surgeons at disclosing periprosthetic joint infection at the time of revision, based on pre- and intra-operative assessment? A study on 16,922 primary total hip arthroplasties reported to the Norwegian Arthroplasty Register
(Journal article; Peer reviewed, 2024)Background and purpose: Revision due to infection, as reported to the Norwegian Arthroplasty Register (NAR), is a surrogate endpoint to periprosthetic joint infection (PJI). We aimed to find the accuracy of the reported ... -
Systematic review of the patient burden of generalised myasthenia gravis in Europe, the Middle East, and Africa
(Journal article; Peer reviewed, 2024)Background Myasthenia gravis (MG) is a rare autoimmune disease characterised by muscle weakness, and progression from ocular (oMG) to generalised (gMG) symptoms results in a substantial negative impact on quality of ... -
Programmed death ligand-1 (PD-L1) clone 22C3 expression in resected colorectal cancer as companion diagnostics for immune checkpoint inhibitor therapy: A comparison study and inter-rater agreement evaluation across proposed cut-offs and predictive (TPS, CPS and IC) scores
(Journal article; Peer reviewed, 2024)Background Expression of programmed death ligand-1 (PD-L1) guides the use of immune checkpoint inhibitors (ICI) in several cancers. In colorectal cancer (CRC), ICI are only approved for metastatic CRC, while several studies ... -
The epidemiology and societal costs of myasthenia gravis in Norway: A non-interventional study using national registry data
(Journal article; Peer reviewed, 2024)Background and purpose With the emergence of new treatment options for myasthenia gravis (MG), there is a need for information regarding epidemiology, healthcare utilization, and societal costs to support economic ... -
Kitesurfing and snowkiting injuries in Norway: a retrospective study
(Journal article; Peer reviewed, 2024)Background Kiteboarding (kitesurfing on water and snowkiting) is a fairly new sport and is defined as a high-risk sport. The injury rate has been reported to be between 6 and 9 per 1000 h. The aim of the study was to ... -
Adverse Childhood Experiences and the Risk of Multiple Sclerosis Development: A Review of Potential Mechanisms
(Journal article; Peer reviewed, 2024)Adverse childhood experiences (ACEs), such as abuse, neglect, and household dysfunction, contribute to long-term systemic toxic stress and inflammation that may last well into adulthood. Such early-life stressors have been ... -
Sjögren’s Syndrome: The Role of Serological Profiles Versus Minor Salivary Gland Histopathology
(Journal article; Peer reviewed, 2024)Between the years 2008 and 2023, 306 patients were referred to the Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, University of Oslo, for salivary gland biopsy after clinical suspicion of Sjögren’s ... -
Amyotrophic lateral sclerosis caused by the C9orf72 expansion in Norway–prevalence, ancestry, clinical characteristics and sociodemographic status
(Journal article; Peer reviewed, 2025)Objective: The most common genetic cause of amyotrophic lateral sclerosis (ALS) is the C9orf72 expansion. A high incidence of this expansion has been detected in Sweden and Finland. This Norwegian population-based study ... -
Increased risk of rehospitalisation and death in older hospital patients at risk of malnutrition: A cohort study
(Journal article; Peer reviewed, 2024)Objectives The aim of the study was to investigate associations between risk of malnutrition and risk of rehospitalisation and death in older hospital patients, and whether the possible associations were modified by age, ... -
Identification and characterization of migraine in pregnancy: A Norwegian registry-based cohort study
(Journal article; Peer reviewed, 2024)Background Migraine is common in women of reproductive age. Migraine’s episodic manifestation and acute and preventive pharmacological treatment options challenge studying drug safety for this condition during pregnancy. ... -
Low maternal iodine intake and subsequent risk of pharmacologically treated hypertension: A population-based prospective cohort study
(Journal article; Peer reviewed, 2025)Background & aims Iodine deficiency is linked to multiple adverse health outcomes, but there is scarce knowledge regarding iodine intake and development of chronic hypertension. We aimed to investigate the prospective ...
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