Department of Clinical Medicine
Recent Submissions
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Colorectal cancer screening with repeated fecal immunochemical test versus sigmoidoscopy: baseline results from a randomized trial
(Journal article; Peer reviewed, 2021)Background and aims: The comparative effectiveness of sigmoidoscopy and fecal immunochemical testing (FIT) for colorectal cancer (CRC) screening is unknown. Methods: Individuals aged 50-74 years living in South-East Norway ... -
Similar early mortality risk after cemented compared with cementless total hip arthroplasty for primary osteoarthritis: data from 188,606 surgeries in the Nordic Arthroplasty Register Association database
(Journal article; Peer reviewed, 2021)Background and purpose — Current literature indicates no difference in 90-day mortality after cemented compared with cementless total hip arthroplasty (THA). However, previous studies are hampered by potential selection ... -
Association between fixation type and revision risk in total knee arthroplasty patients aged 65 years and older: a cohort study of 265,877 patients from the Nordic Arthroplasty Register Association 2000–2016
(Journal article; Peer reviewed, 2021)Background and purpose — The population of the Nordic countries is aging and the number of elderly patients undergoing total knee arthroplasty (TKA) is also expected to increase. Reliable fixation methods are essential to ... -
Five salmon dinners per week were not sufficient to prevent the reduction in serum vitamin D in autumn at 60° north latitude: A randomised trial
(Journal article; Peer reviewed, 2020)Low serum concentrations of several vitamins have been linked to increased risk of diseases including insulin resistance and type 2 diabetes (T2D). Fish is a good source of several vitamins, and the prevalence of T2D is ... -
Cognitive behavior therapy for internalizing disorders in children and adolescents in routine clinical care: A systematic review and meta-analysis
(Journal article; Peer reviewed, 2020)Cognitive behavioral therapy (CBT) has received considerable empirical support for internalizing disorders including anxiety, depression, obsessive-compulsive disorder, and post-traumatic stress disorder in children and ... -
Pregnancy outcomes after exposure to interferon beta: a register-based cohort study among women with MS in Finland and Sweden
(Journal article; Peer reviewed, 2020)Background Our aim was to estimate and compare the prevalence of adverse pregnancy outcomes among pregnant women with multiple sclerosis (MS) exposed to interferon beta (IFNB) and among women with MS unexposed to any MS ... -
Development and Validation of a Simple Ultrasound Activity Score for Crohn’s Disease
(Journal article; Peer reviewed, 2020)Background and Aims To improve management of patients with Crohn’s disease, objective measurements of disease activity are needed. Ileocolonoscopy is the current reference standard but has limitations that restrict repeated ... -
Leptin receptor signaling regulates protein synthesis pathways and neuronal differentiation in pluripotent stem cells
(Journal article; Peer reviewed, 2020)The role of leptin receptor (OB-R) signaling in linking pluripotency with growth and development and the consequences of dysfunctional leptin signaling on progression of metabolic disease is poorly understood. Using a ... -
Increasing but levelling out risk of revision due to infection after total hip arthroplasty: a study on 108,854 primary THAs in the Norwegian Arthroplasty Register from 2005 to 2019
(Journal article; Peer reviewed, 2020)Background and purpose — Focus on prevention, surveillance, and treatment of infection after total hip arthroplasty (THA) in the last decade has resulted in new knowledge and guidelines. Previous publications have suggested ... -
Failed meniscal repairs after anterior cruciate ligament reconstruction increases risk of revision surgery
(Journal article; Peer reviewed, 2020)Background: Failed anterior cruciate ligament (ACL) reconstruction (ACLR) can lead to reduced quality of life because of recurrent episodes of instability, restrictions in level of activity, and development of osteoarthritis. ... -
DiaSHoT18: A cross-sectional national health and well-being survey of university students with type 1 diabetes
(Journal article; Peer reviewed, 2020-09-17)Objective To achieve a better understanding in how university students live with and are able to manage their type 1 diabetes (T1D). Methods In 2018, all fulltime Norwegian students aged 18 to 35 years pursuing higher ... -
Total hip arthroplasties in the Dutch Arthroplasty Register (LROI) and the Nordic Arthroplasty Register Association (NARA): comparison of patient and procedure characteristics in 475,685 cases
(Journal article; Peer reviewed, 2021)Background and purpose — Collaborations between arthroplasty registries are important in order to create the possibility of detecting inferior implants early and improve our understanding of differences between nations in ... -
Development and Validation of a Simple Ultrasound Activity Score for Crohn’s Disease
(Journal article; Peer reviewed, 2020-06-06)Background and Aims To improve management of patients with Crohn’s disease, objective measurements of disease activity are needed. Ileocolonoscopy is the current reference standard but has limitations that restrict repeated ... -
Centralizing a national pancreatoduodenectomy service: striking the right balance
(Journal article; Peer reviewed, 2020)Background Centralization of pancreatic surgery is currently called for owing to superior outcomes in higher-volume centres. Conversely, organizational and patient concerns speak for a moderation in centralization. Consensus ... -
Does childhood trauma influence cognitive functioning in schizophrenia? The association of childhood trauma and cognition in schizophrenia spectrum disorders.
(Journal article; Peer reviewed, 2020)Childhood trauma (CT) is a risk factor for schizophrenia spectrum disorders (SSDs), and cognitive impairment is a core feature and a vulnerability marker of SSDs. Studies of the relationship between CT and cognitive ... -
A prospective observational study of why people are medically evacuated from offshore installations in the North Sea
(Journal article; Peer reviewed, 2020)Objectives Few studies have described evacuations due to medical emergencies from the offshore installations in the North Sea, though efficient medical service is essential for the industrial activities in this area. The ... -
Comparative effectiveness of microdecompression alone vs decompression plus instrumented fusion in lumbar degenerative spondylolisthesis
(Journal article; Peer reviewed, 2020)Importance Conflicting evidence and large practice variation are present in the surgical treatment of degenerative spondylolisthesis. More than 90% of surgical procedures in the United States include instrumented fusion ... -
Brain amyloid and vascular risk are related to distinct white matter hyperintensity patterns
(Journal article; Peer reviewed, 2020)White matter hyperintensities (WMHs) are associated with vascular risk and Alzheimer’s disease. In this study, we examined relations between WMH load and distribution, amyloid pathology and vascular risk in 339 controls ... -
Impact of different methods defining post-stroke neurocognitive disorder: The Nor-COAST study
(Journal article; Peer reviewed, 2020-03-16)Introduction Post‐stroke neurocognitive disorder (NCD) is common; prevalence varies between studies, partially related to lack of consensus on how to identify cases. The aim was to compare the prevalence of post‐stroke ... -
Early indicators of disease progression in Fabry disease that may indicate the need for disease-specific treatment initiation: Findings from the opinion-based PREDICT-FD modified Delphi consensus initiative
(Journal article; Peer reviewed, 2020)Objectives The PRoposing Early Disease Indicators for Clinical Tracking in Fabry Disease (PREDICT-FD) initiative aimed to reach consensus among a panel of global experts on early indicators of disease progression that may ...
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