Department of Clinical Medicine
Nye registreringer
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Breast cancer of the young: Exploring age-related breast cancer biology
(Doctoral thesis, 2023-11-30)Brystkreft er en sykdom som i en økende grad rammer kvinner i Norge og den vestlige verden. Brystkreft blant yngre kvinner er også økende, og dessuten assosiert med mer aggressiv tumor type og verre klinisk utfall sammenlignet ... -
Systems analyses of the Fabry kidney transcriptome and its response to enzyme replacement therapy identified and cross-validated enzyme replacement therapy-resistant targets amenable to drug repurposing
(Journal article; Peer reviewed, 2023)Fabry disease is a rare disorder caused by variations in the alpha-galactosidase gene. To a degree, Fabry disease is manageable via enzyme replacement therapy (ERT). By understanding the molecular basis of Fabry nephropathy ... -
Patient-reported outcome and fracture-related infection after ankle fracture surgery
(Doctoral thesis, 2023-12-01)Ankelbrudd er det tredje mest vanlige bruddet som opereres etter håndleddsbrudd og hoftebrudd. Disse bruddene utgjør 10% av alle brudd. Operativ behandling er ofte nødvendig for å hindre utvikling av stivhet, smerte og ... -
Functional and Prognostic Role of MicroRNAs in Cancer Associated Fibroblasts and Stroma in Oral Squamous Cell Carcinoma
(Doctoral thesis, 2023-11-23)Nyere studier har vist at forandringer i bindevevscellene som omgir kreftsvulsten er viktige for utviklingen av munnhulekreft. Kreft stroma kan regulere fenotypen av kreftcellene, og på den måten kan påvirke klinisk forløpet ... -
Congener-specific accumulation of persistent organic pollutants in marine fish from the Northeast Atlantic Ocean
(Journal article; Peer reviewed, 2023)Bioaccumulation of persistent organic pollutants (POPs) in marine fish may pose a health risk to human consumers. Using data from ∼8400 individuals of 15 fish species collected in the North-East Atlantic Ocean (NEAO), we ... -
A standardized clinical pathway for hip fracture patients is associated with reduced mortality: data from the Norwegian Hip Fracture Register
(Journal article; Peer reviewed, 2023)Purpose: A standardized clinical pathway is recommended for hip fracture patients. We aimed to survey standardization of treatment in Norwegian hospitals and to investigate whether this affected 30-day mortality and quality ... -
Increasing risk of revision due to infection after primary total hip arthroplasty: results from the Nordic Arthroplasty Register Association
(Journal article; Peer reviewed, 2023)Background and purpose: The incidence of periprosthetic joint infection after total hip arthroplasty (THA) may be increasing. We performed time-trend analyses of risk, rates, and timing of revision due to infection after ... -
Does maternal genetic liability to folate deficiency influence the risk of antiseizure medication-associated language impairment and autistic traits in children of women with epilepsy?
(Journal article; Peer reviewed, 2023)Background: Prenatal exposure to antiseizure medication (ASM) may lead to low plasma folate concentrations and is associated with impaired neurodevelopment. Objectives: To examine whether maternal genetic liability to ... -
Effect of ADHD Medication on Criminality and Injuries : Quasi-Experimental Evidence for Patients on the Margin of Treatment
(Doctoral thesis, 2023-11-07)Attention-deficit/hyperactivity disorder (ADHD) er den vanligste nevropsykiatriske lidelsen hos barn og unge. Store geografiske variasjoner i diagnostisering og medisinering av ADHD har bidratt til bekymringer om under- ... -
Effect of Pharmacological Treatment of Attention-Deficit/Hyperactivity Disorder on Criminality
(Journal article; Peer reviewed, 2023)Objective: Criminality rates are higher among persons with attention-deficit/hyperactivity disorder (ADHD), and evidence that medication reduces crime is limited. Medication rates between clinics vary widely even within ... -
Effect of ADHD medication on risk of injuries: a preference-based instrumental variable analysis
(Journal article; Peer reviewed, 2023)ADHD is associated with an increased risk of injury. Causal evidence for effects of pharmacological treatment on injuries is scarce. We estimated effects of ADHD medication on injuries using variation in provider preference ... -
Seed Amplification Assay as a Diagnostic Tool in Newly-Diagnosed Parkinson's Disease
(Journal article; Peer reviewed, 2023)Seed amplification assays (SAA) are the first credible molecular assay for Parkinson’s disease (PD). However, the value of SAA to support the clinicians’ initial diagnosis of PD is not clear. In our study, we analyzed ... -
Diagnostic utility of oropharyngeal swabs as an alternative to lower respiratory tract samples for PCR-based syndromic testing in patients with community-acquired pneumonia
(Journal article; Peer reviewed, 2023)Syndromic PCR-based analysis of lower respiratory tract (LRT) samples in patients with community-acquired pneumonia (CAP) improves the bacterial yield and time-to-results compared to culture-based methods. However, obtaining ... -
Syndromic molecular testing in adults hospitalized for suspected community-acquired pneumonia
(Doctoral thesis, 2023-10-26)Den mikrobielle etiologien hos pasienter med samfunnservervet lungebetennelse (CAP) blir ofte ikke avklart på grunn av utilstrekkelige mikrobiologiske metoder og vanskeligheter med å skaffe prøver fra nedre luftveier. Rask ... -
Clinical trials of neoadjuvant immune checkpoint inhibitors for early-stage operable colon and rectal cancer
(Journal article; Peer reviewed, 2023)Background: Immune checkpoint inhibitors (ICI) have become first-line treatment for metastatic colorectal cancer (CRC) with deficient mismatch repair (dMMR). Despite the remarkable response reported in preliminary trials, ... -
Long-Term Use of Amoxicillin Is Associated with Changes in Gene Expression and DNA Methylation in Patients with Low Back Pain and Modic Changes
(Journal article; Peer reviewed, 2023-07-21)Long-term antibiotics are prescribed for a variety of medical conditions, recently including low back pain with Modic changes. The molecular impact of such treatment is unknown. We conducted longitudinal transcriptome and ... -
Identification of diagnostic and prognostic biomarkers of PD using a multiplex proteomics approach
(Journal article; Peer reviewed, 2023)Given the complexity of Parkinson's disease (PD), achieving acceptable diagnostic and prognostic accuracy will require the support of a panel of diverse biomarkers. We used Proximity extension assays to measure a panel of ... -
Visual function in Norwegian children aged 5–13 years with prenatal exposure to opioid maintenance therapy: A case–control study
(Journal article; Peer reviewed, 2023)Purpose: To assess various aspects of visual function in school children prenatally exposed to opioid maintenance therapy (OMT) and to explore possible outcome differences between prenatal methadone and buprenorphine ... -
Outcomes of patients aged ≥80 years with respiratory failure initially treated with non-invasive ventilation in European intensive care units before and during COVID-19 pandemic
(Journal article; Peer reviewed, 2023)Background Non-invasive ventilation (NIV) has been commonly used to treat acute respiratory failure due to COVID-19. In this study we aimed to compare outcomes of older critically ill patients treated with NIV before and ... -
Effective resting-state connectivity in severe unipolar depression before and after electroconvulsive therapy
(Journal article; Peer reviewed, 2023)Background Electroconvulsive therapy (ECT) is one of the most effective treatments for severe depressive disorders. A recent multi-center study found no consistent changes in correlation-based (undirected) resting-state ...
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