Department of Clinical Science
Recent Submissions
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SARS-CoV-2 infection in healthcare workers, and biomarkers of long COVID
(Doctoral thesis, 2024-11-27)I denne doktorgradsavhandlingen har vi studert risikoen for å bli smittet av SARS-CoV-2 virus blant norske helsearbeidere gjennom de ulike covid-19 smittebølgene. Kunnskap om prevalens og risikofaktorer for smitte hos ... -
Prostate Biopsies Can Be Omitted in Most Patients with a Positive Stockholm3 Test and Negative Prostate Magnetic Resonance Imaging
(Journal article; Peer reviewed, 2024)Background Magnetic resonance imaging (MRI) combined with the Stockholm3 test can be used to inform biopsy decision-making in patients with a suspicion of prostate cancer. Objective To determine the consequence of ... -
Effect of Therapeutic Drug Monitoring on Adherence and Blood Pressure: A Multicenter Randomized Clinical Trial
(Journal article; Peer reviewed, 2024)Background: Drug concentration in blood or urine is an acknowledged method to detect nonadherence. Observational studies suggest that informing patients about low or absent serum drug levels improves blood pressure (BP). ... -
Efficient CAR T cell targeting of the CA125 extracellular repeat domain of MUC16
(Journal article; Peer reviewed, 2024)Background Ovarian cancer (OC) is the leading cause of death from gynecologic malignancies in the Western world. Contributing factors include a high frequency of late-stage diagnosis, the development of chemoresistance, ... -
Association between dietary macronutrient composition and plasma one-carbon metabolites and B-vitamin cofactors in patients with stable angina pectoris
(Journal article; Peer reviewed, 2024)Elevated plasma concentrations of several one-carbon metabolites are associated with increased CVD risk. Both diet-induced regulation and dietary content of one-carbon metabolites can influence circulating concentrations ... -
Characterisation of global and regional mitral annular strains in an acute porcine model
(Journal article, 2024)OBJECTIVES This study aimed to explore regional mitral annular strain using a novel computational method. METHODS Eight pigs underwent implantation with piezoelectric transducers around the mitral annulus. Interventions ... -
Extracellular matrix remodelling pathway in peripheral blood mononuclear cells from severe COVID-19 patients: an explorative study
(Journal article; Peer reviewed, 2024)There is a reciprocal relationship between extracellular matrix (ECM) remodelling and inflammation that could be operating in the progression of severe COVID-19. To explore the immune-driven ECM remodelling in COVID-19, ... -
Sex differences in left atrial volumes, mechanics, and stiffness in primary mitral regurgitation - a combined 2D and 3D echocardiographic study
(Journal article; Peer reviewed, 2024)Aims Mitral regurgitation (MR) causes left atrial (LA) enlargement and impaired reservoir function. We assessed whether changes in LA size, strain, and stiffness in significant (moderate or greater) primary MR are ... -
Protein and transcriptional biomarker profiling may inform treatment strategies in lower respiratory tract infections by indicating bacterial–viral differentiation
(Journal article; Peer reviewed, 2024)Lower respiratory tract infections (LRTIs) remain a significant global cause of infectious disease-related mortality. Accurate discrimination between acute bacterial and viral LRTIs is crucial for optimal patient care, ... -
Trends in overweight and obesity in Bergen, Norway, using data from routine child healthcare 2010–2022
(Journal article; Peer reviewed, 2024)Aim Trends in childhood overweight, obesity and severe obesity have been lacking in Norway. This study assessed pre-pandemic trends from 2010 to 2019 and evaluated differences in prevalence during the 2020–2022 pandemic ... -
Appropriateness and outcomes of hospitalized patients telemetry monitored for cardiac arrhythmias in accordance with the American Heart Association Practice Standards–A multicenter study
(Journal article; Peer reviewed, 2024)Background To the best of our knowledge, no prospective research studies have compared clinical practice to the American Heart Association (AHA) updated practice standards for in-hospital telemetry monitoring. Objectives Our ... -
Small Cell Lung Cancer in Norway: Patterns of Care by Health Region and Survival Trends
(Journal article; Peer reviewed, 2024)Introduction/Background There has been a marked survival improvement for patients with non–small-cell lung cancer. We describe the national trends in characteristics and survival, and geographical differences in diagnostic ... -
DNA methylation risk score for type 2 diabetes is associated with gestational diabetes
(Journal article; Peer reviewed, 2024-02-13)Background: Gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM) share many pathophysiological factors including genetics, but whether epigenetic marks are shared is unknown. We aimed to test whether a ... -
Neonatal Sepsis Episodes and Retinopathy of Prematurity in Very Preterm Infants
(Journal article; Peer reviewed, 2024)Importance: Retinopathy of prematurity (ROP) is a major morbidity of preterm infants causing visual impairment, including blindness, for which timely treatment is vital and prevention is key. Increasing evidence suggests ... -
Divergent epigenetic responses to perinatal asphyxia in severe mental disorders
(Journal article; Peer reviewed, 2024)Epigenetic modifications influenced by environmental exposures are molecular sources of phenotypic heterogeneity found in schizophrenia and bipolar disorder and may contribute to shared etiopathogenetic mechanisms of these ... -
Escalated complement activation during hospitalization is associated with higher risk of 60-day mortality in SARS-CoV-2-infected patients
(Journal article; Peer reviewed, 2024)Background: The complement system, an upstream recognition system of innate immunity, is activated upon SARS-CoV-2 infection. To gain a deeper understanding of the extent and duration of this activation, we investigated ... -
Severe isolated exudative vitreoretinopathy caused by biallelic FZD4 variants
(Journal article; Peer reviewed, 2024)Familial exudative vitreoretinopathy (FEVR) is linked to disruption of the Norrin/Frizzled-4 signaling pathway, which plays an important role in retinal angiogenesis. Severe or complete knock-down of proteins in the pathway ... -
Essential trace elements in Norwegian obese patients before and 12 months after Roux-en-Y gastric bypass surgery: Copper, manganese, selenium and zinc
(Journal article; Peer reviewed, 2020)Objectives: The objective of the present study was to assess trace element status in morbidly obese subjects before and one year after Roux-en-Y gastric bypass (RYGB) in order to identify possible deficiencies. Methods: ... -
Evaluation of sex inequity in lung-cancer-specific survival
(Journal article; Peer reviewed, 2024)Background: Whether sex is an independent prognostic factor in lung cancer survival is the subject of ongoing debate. Both large national registries and single hospital studies have shown conflicting findings. In this ... -
Normal range and risk factors for deviating body temperatures during the first 24 hours in term-born infants under standardised care: an observational study
(Journal article; Peer reviewed, 2024)Objective Body temperature for a known ambient temperature is not known for infants born at term. We aimed to determine the normal range and the incidences of hypothermia and hyperthermia during the first 24 hours of life ...