• Human Leukocyte Antigen alleles associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) 

  Lande, Asgeir; Fluge, Øystein; Strand, Elin Bolle; Flåm, Siri Tennebø; Sosa, Daisy Duarte; Mella, Olav; Egeland, Torstein; Saugstad, Ola Didrik; Lie, Benedicte Alexandra; Viken, Marte K (Journal article; Peer reviewed, 2020)

  The etiology and pathogenesis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) are unknown, and autoimmunity is one of many proposed underlying mechanisms. Human Leukocyte Antigen (HLA) associations are ...

• Impact of the left ventricular lead on the efficacy of Cardiac Resynchronization Therapy for heart failure. : Electrophysiologic and clinical trials investigating active fixation left ventricular lead in cardiac resynchronization therapy. 

  Keilegavlen, Håvard (Doctoral thesis, 2021-04-09)

  Background: This thesis examines the performance of different left ventricular (LV) leads and in particular a novel bipolar LV lead with a side helix for active fixation. Cardiac resynchronization therapy (CRT) provides ...

• CD24-targeted intraoperative fluorescence image-guided surgery leads to improved cytoreduction of ovarian cancer in a preclinical orthotopic surgical model 

  Kleinmanns, Katrin; Fosse, Vibeke Samuelsen; Davidson, Ben; de Jalón, Elvira Garcia; Tenstad, Olav; Bjørge, Line; McCormack, Emmet (Journal article; Peer reviewed, 2020)

  Background The completeness of resection is a key prognostic indicator in patients with ovarian cancer, and the application of tumour-targeted fluorescence image-guided surgery (FIGS) has led to improved detection of ...

• Endurance exercise training volume is not associated with progression of coronary artery calcification 

  Kleiven, Øyunn; Bjørkavoll-Bergseth, Magnus; Omland, Torbjørn; Aakre, Kristin Moberg; Frøysa, Vidar; Erevik, Christine B.; Greve, Ole Jacob; Melberg, Tor Harald; Auestad, Bjørn Henrik; Skadberg, Øyvind; Edvardsen, Thor; Ørn, Stein (Journal article; Peer reviewed, 2020)

  Background Recent cross‐sectional studies have suggested a dose‐dependent relationship between lifelong exposure to physical activity and the burden of calcified coronary artery disease (CAD). No longitudinal studies have ...

• Maternal and child gluten intake and association with type 1 diabetes: The Norwegian Mother and Child Cohort Study 

  Lund-Blix, Nicolai Andre; Tapia, German; Mårild, Karl Staffan; Brantsæter, Anne Lise; Njølstad, Pål Rasmus; Joner, Geir; Skrivarhaug, Torild; Størdal, Ketil; Stene, Lars Christian Mørch (Journal article; Peer reviewed, 2020)

  Background The relationship between maternal gluten intake in pregnancy, offspring intake in childhood, and offspring risk of type 1 diabetes has not been examined jointly in any studies. Our aim was to study the relationship ...

• Bone mineral density and vitamin D in paediatric intestinal failure patients receiving home parenteral nutrition 

  Kvammen, Janne Anita; Thomassen, Rut Anne; Kjeserud, Christina; Sæland, Camilla; Godang, Kristin; Bollerslev, Jens; Thorsby, Per Medbøe; Juliusson, Petur Benedikt; Bentsen, Beint Sigmund; Henriksen, Christine (Journal article; Peer reviewed, 2020)

  Background & aims Patients with intestinal failure (IF) are dependent on long-term home parenteral nutrition (HPN) to ensure growth and development. The primary aim of the present study was to assess bone mineral density ...

• Cognitive impairment - role of vascular risk factors and lipid alterations for development and progression 

  Bergland, Anne Katrine (Doctoral thesis, 2021-03-26)

  Background: Dementia is a growing challenge, and there is no curative treatment available. The most common cause of dementia is Alzheimer’s disease (AD), where treatment studies focusing on anti-amyloid treatment have thus ...

• Increased Plasma Soluble Interleukin-2 Receptor Alpha Levels in Patients With Long-Term Type 1 Diabetes With Vascular Complications Associated With IL2RA and PTPN2 Gene Polymorphisms 

  Keindl, Magdalena; Fedotkina, Olena; du Plessis, Elsa; Jain, Ruchi; Bergum, Brith; Mygind Jensen, Troels; Laustrup Møller, Cathrine; Falhammar, Henrik; Nyström, Thomas; Catrina, Sergiu-Bogdan; Jörneskog, Gun; Groop, Leif; Eliasson, Mats; Eliasson, Björn; Brismar, Kerstin; Nilsson, Peter M.; Berg, Tore Julsrud; Appel, Silke; Lyssenko, Valeriya (Journal article; Peer reviewed, 2020)

  Type 1 diabetes (T1D) is largely considered an autoimmune disease leading to the destruction of insulin-producing pancreatic β cells. Further, patients with T1D have 3–4-fold increased risk of developing micro- and ...

• Atherogenic Lipid Ratios Related to Myeloperoxidase and C-Reactive Protein Levels in Psychotic Disorders 

  Reponen, Elina Johanna; Dieset, Ingrid; Tesli, Martin Steen; Mørch, Ragni Helene; Aas, Monica; Vedal, Trude Seselie Jahr; Haug, Elisabeth; Drange, Ole Kristian; Steen, Nils Eiel; Hope, Sigrun; Szabo, Attila; Gohar, Sherif Mostafa Mohamed Ahmed; Wedervang-Resell, Kirsten; Djurovic, Srdjan; Melle, Ingrid; Aukrust, Pål; Andreassen, Ole Andreas; Ueland, Thor (Journal article; Peer reviewed, 2020)

  Background: Cardiovascular disease (CVD) is a major cause of premature death in patients with psychotic disorders, where dyslipidemia occurs frequently. In the pathogenesis of these serious mental disorders, a low-grade ...

• N-terminal pro-B-type natriuretic peptide as a prognostic indicator for 30-day mortality following out-of-hospital cardiac arrest: A prospective observational study 

  Aarsetøy, Reidun; Omland, Torbjørn; Røsjø, Helge; Strand, Heidi; Lindner, Thomas Werner; Aarsetøy, Hildegunn; Staines, Harry; Nilsen, Dennis W.T. (Journal article; Peer reviewed, 2020-08-24)

  Background Early risk stratification applying cardiac biomarkers may prove useful in sudden cardiac arrest patients. We investigated the prognostic utility of early-on levels of high sensitivity cardiac troponin-T (hs-cTnT), ...

• Plasma levels of interleukin 27 in falciparum malaria is increased independently of co-infection with HIV: potential immune-regulatory role during malaria 

  Otterdal, Kari; Berg, Åse; Michelsen, Annika; Patel, Sam; Gregersen, Ida; Sagen, Ellen Lund; Halvorsen, Bente; Yndestad, Arne; Ueland, Thor; Langeland, Nina; Aukrust, Pål (Journal article; Peer reviewed, 2020)

  Background The immune response during falciparum malaria mediates both harmful and protective effects on the host; however the participating molecules have not been fully defined. Interleukin (IL)-27 is a pleiotropic ...

• Rosuvastatin alters the genetic composition of the human gut microbiome 

  Kummen, Martin; Solberg, Ole Geir; Larsen, Christopher Storm; Holm, Kristian; Ragnarsson, Asgrimur; Trøseid, Marius; Vestad, Beate; Skårdal, Rita; Yndestad, Arne; Ueland, Thor; Svardal, Asbjørn M.; Berge, Rolf Kristian; Seljeflot, Ingebjørg; Gullestad, Lars; Karlsen, Tom Hemming; Aaberge, Lars; Aukrust, Pål; Hov, Johannes Espolin Roksund (Journal article; Peer reviewed, 2020)

  The gut microbiome contributes to the variation of blood lipid levels, and secondary bile acids are associated with the effect of statins. Yet, our knowledge of how statins, one of our most common drug groups, affect the ...

• Plasma parasitemia as assessed by quantitative PCR in relation to clinical disease severity in African adults with falciparum malaria with and without HIV co-infection 

  Berg, Åse; Patel, Sam; Tellevik, Marit Gjerde; Haanshuus, Christel Gill; Dalen, Ingvild; Otterdal, Kari; Ueland, Thor; Moyo, Sabrina John; Aukrust, Pål; Langeland, Nina (Journal article; Peer reviewed, 2020)

  Purpose When considering malaria disease severity, estimation of parasitemia in erythrocytes is important, but sometimes misleading, since the infected erythrocytes may be sequestered in peripheral capillaries. In African ...

• Fatigue in primary Sjögren’s syndrome: A proteomic pilot study of cerebrospinal fluid 

  Larssen, Eivind; Brede, Cato; Hjelle, Anne; Tjensvoll, Anne Bolette; Norheim, Katrine Brække; Bårdsen, Kjetil; Jonsdottir, Kristin; Ruoff, Peter; Omdal, Roald; Nilsen, Mari Mæland (Journal article; Peer reviewed, 2019)

  Objectives: Fatigue is a frequent and often disabling phenomenon that occurs in patients with chronic inflammatory and immunological diseases, and the underlying biological mechanisms are largely unknown. Because fatigue ...

• How does the WHO Surgical Safety Checklist fit with existing perioperative risk management strategies? An ethnographic study across surgical specialties 

  Wæhle, Hilde Valen; Haugen, Arvid Steinar; Wiig, Siri; Softeland, Eirik; Sevdalis, Nick; Harthug, Stig (Journal article; Peer reviewed, 2020)

  Background The World Health Organization (WHO) Surgical Safety Checklist (SSC) has demonstrated beneficial impacts on a range of patient- and team outcomes, though variation in SSC implementation and staffʼs perception ...

• Interleukin-1-related activity and hypocretin-1 in cerebrospinal fluid contribute to fatigue in primary Sjögren’s syndrome 

  Bårdsen, Kjetil; Brede, Cato; Kvivik, Ingeborg; Kvaløy, Jan Terje; Jonsdottir, Kristin; Tjensvoll, Anne Bolette; Ruoff, Peter; Omdal, Roald (Journal article; Peer reviewed, 2019)

  Background Fatigue is a common and sometimes debilitating phenomenon in primary Sjögren’s syndrome (pSS) and other chronic inflammatory diseases. We aimed to investigate how IL-1 β-related molecules and the neuropeptide ...

• Ultrasound- and Microbubble-Assisted Gemcitabine Delivery to Pancreatic Cancer Cells 

  Bjånes, Tormod Karlsen; Kotopoulis, Spiros; Murvold, Elsa Thodesen; Kamceva, Tina; Gjertsen, Bjørn Tore; Gilja, Odd Helge; Schjøtt, Jan; Riedel, Bettina; McCormack, Emmet (Journal article; Peer reviewed, 2020)

  Pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer death worldwide. Poor drug delivery to tumours is thought to limit chemotherapeutic treatment efficacy. Sonoporation combines ultrasound (US) and microbubbles ...

• Intracellular Cytidine Deaminase Regulates Gemcitabine Metabolism in Pancreatic Cancer Cell Lines 

  Bjånes, Tormod Karlsen; Jordheim, Lars Petter; Schjøtt, Jan; Kamceva, Tina; Cros-Perrial, Emeline; Langer, Anika; de Garibay, Gorka Ruiz; Kotopoulis, Spiros; McCormack, Emmet; Riedel, Bettina (Journal article; Peer reviewed, 2020)

  Cytidine deaminase (CDA) is a determinant of in vivo gemcitabine elimination kinetics and cellular toxicity. The impact of CDA activity in pancreatic ductal adenocarcinoma (PDAC) cell lines has not been elucidated. We ...

• Proteome and Phosphoproteome Changes Associated with Prognosis in Acute Myeloid Leukemia 

  Aasebø, Elise; Berven, Frode; Bartaula-Brevik, Sushma; Stokowy, Tomasz; Hovland, Randi; Vaudel, Marc; Døskeland, Stein Ove; Mc Cormack, Emmet; Batth, Tanveer S; Olsen, Jesper V; Bruserud, Øystein; Selheim, Frode; Hernandez-Valladares, Maria (Journal article; Peer reviewed, 2020)

  Acute myeloid leukemia (AML) is a hematological cancer that mainly affects the elderly. Although complete remission (CR) is achieved for the majority of the patients after induction and consolidation therapies, nearly ...

• CD24-targeted fluorescence imaging in patient-derived xenograft models of high-grade serous ovarian carcinoma 

  Kleinmanns, Katrin; Bischof, Katharina; Anandan, Shamundeeswari; Popa, Mihaela Lucia; Akslen, Lars A.; Gjertsen, Bjørn Tore; Karlsen, Ida; Fosse, Vibeke Samuelsen; Bjørge, Line; Mc Cormack, Emmet (Journal article; Peer reviewed, 2020)

  Background The survival rate of patients with advanced high-grade serous ovarian carcinoma (HGSOC) remains disappointing. Clinically translatable orthotopic cell line xenograft models and patient-derived xenografts (PDXs) ...

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