• Monocytic Differentiation of Human Acute Myeloid Leukemia Cells: A Proteomic and Phosphoproteomic Comparison of FAB-M4/M5 Patients with and without Nucleophosmin 1 Mutations 

  Selheim, Frode; Aasebø, Elise; Reikvam, Håkon; Bruserud, Øystein; Valladares, Maria del Carmen Hernandez (Journal article; Peer reviewed, 2024-05-07)

  Even though morphological signs of differentiation have a minimal impact on survival after intensive cytotoxic therapy for acute myeloid leukemia (AML), monocytic AML cell differentiation (i.e., classified as French/Amer ...

• Factors associated with change in arterial stiffness in patients with rheumatoid arthritis: the JointHeart study 

  Linde, Anja; Gerdts, Eva; Fevang, Bjørg Tilde Svanes; Eilertsen, Rune Krogh; Kringeland, Ester Anne; Alsing, Christian Lillebø; Midtbø, Helga Bergljot (Journal article; Peer reviewed, 2024)

  Background: Rheumatoid arthritis (RA) predominantly affects women and is associated with hypertension and arterial stiffness. We explored factors associated with change in arterial stiffness in patients with RA treated ...

• Sex effects on DNA methylation affect discovery in epigenome-wide association study of schizophrenia 

  Tesfaye, Markos; Spindola, Leticia Maria Nery; Stavrum, Anne-Kristin Støbakk; Shadrin, Alexey; Melle, Ingrid; Andreassen, Ole A.; Hellard, Stephanie Francoise Claire Le (Journal article; Peer reviewed, 2024)

  Sex differences in the epidemiology and clinical characteristics of schizophrenia are well-known; however, the molecular mechanisms underlying these differences remain unclear. Further, the potential advantages of ...

• Longitudinal analysis of the skin microbiome in association with hand eczema, hand hygiene practices and moisturizer use 

  Vindenes, Hilde Kristin; Dregenes, Christine; Abouelhana, Hesham Amin Mohamed; Irgens-Hansen, Kaja; Svanes, Cecilie; Bertelsen, Randi Jacobsen (Journal article; Peer reviewed, 2024)

  Background: The skin microbiota maintains a physical and immunological barrier to the environment. Little is known about how the microbiome changes over time or the effect of hand hygiene practices and moisturizer ...

• Serum neurofilament light chain associates with symptom burden in Lyme neuroborreliosis patients: a longitudinal cohort study from Norway 

  Skarstein, Ingerid; Ulvestad, Elling; Solheim, Anne Marit; Vedeler, Christian; Ljøstad, Unn; Mygland, Åse; Eikeland, Randi; Reiso, Harald; Lorentzen, Åslaug Rudjord; Bos-Haugen, Steffan Daniel (Journal article; Peer reviewed, 2024)

  Objectives: Serum neurofilament light chain (sNfL), an indicator of neuronal damage, is increasingly recognized as a potential biomarker for disease activity in neurodegenerative disorders. In this study, we wanted to ...

• Methodological Approaches to Experimental Evaluation of Neuroprotective Action of Potential Drugs 

  Belenichev, Igor; Bukhtiyarova, Nina; Ryzhenko, Victor; Makyeyeva, Lyudmyla; Morozova, Oksana; Oksenych, Valentyn; Kamyshnyi, Oleksandr (Journal article; Peer reviewed, 2024-09-28)

  The authors propose a novel approach to a comprehensive evaluation of neuroprotective effects using both in vitro and in vivo methods. This approach allows for the initial screening of numerous newly synthesized chemical ...

• Taxonomic diversity and abundance of enchytraeids (Annelida, Clitellata, Enchytraeida) in the Northern Palaearctic. 1. Asian part 

  Degtyarev, Maxim I.; Saifutdinov, Ruslan A.; Korobushkin, Daniil I.; Bastrakov, Alexander I.; Danilova, Margarita A.; Davydov, Ivan D.; Gorbunova, Anastasia Yu.; Guseva, Polina A.; Karlik, Evgeniy I.; Koshchanova, Roza E.; Kuznetsova, Ksenia; Lebedev, Iurii M.; Medvedev, Dmitriy A.; Obolenskiy, Roman R.; Popova, Anna V.; Pronina, Nina A.; Rybalov, Leonid B.; Surov, Alexei V.; Tadzhimov, Akmal B.; Tarasov, Alexander I.; Vasiliev, Vladislav A.; Zaitsev, Andrey S.; Zvychaynaya, Elena Yu.; Gongalsky, Konstantin B. (Journal article; Peer reviewed, 2024)

  Background: Enchytraeids, or potworms, are tiny oligochaetes that are distributed worldwide in many terrestrial, freshwater and marine ecosystems. Despite their key role in the functioning of ecosystems, the diversity and ...

• Quantitative proteomics reveals serum proteome alterations during metastatic disease progression in breast cancer patients 

  Kaur, Jaspreet; Jung, Sung Yun; Austdal, Marie; Arun, Aaditya Krishna; Helland, Thomas; Mellgren, Gunnar; Lende, Tone Hoel; Janssen, Emiel; Søiland, Håvard; Aneja, Ritu (Journal article; Peer reviewed, 2024)

  Background Tumor recurrence and metastatic progression remains the leading cause for breast cancer related mortalities. However, the proteomes of patient- matched primary breast cancer (BC) and metastatic lesions have ...

• Increasing region of interest width reduces neonatal circumferential strain 

  Mørch, Johannes Kjartansson; Kolnes, Elisabeth Horne; Greve, Gottfried; Omdal, Tom Roar; Ebbing, Cathrine; Kessler, Jørg; Khan, Umael (Journal article; Peer reviewed, 2024)

  Objective There is growing interest in speckle tracking echocardiography-derived strain as a measure of left ventricular function in neonates. However, knowledge gaps remain regarding the effect of image acquisition and ...

• Germline variants in patients diagnosed with pediatric soft tissue sarcoma 

  Yndestad, Synnøve; Haugland, Hans Kristian; Goplen, Dorota Katarzyna Pazdyk; Wojcik, Dorota; Knappskog, Stian; Lønning, Per Eystein (Journal article; Peer reviewed, 2024)

  Background: While soft tissue sarcomas affect younger patients, few studies have assessed the distribution of underlying pathogenic germline variants. Patients and methods: We retrospectively identified all pediatric ...

• Decreased T-cell response against latent cytomegalovirus infection does not correlate with anti-IFN autoantibodies in patients with APECED 

  Hetemäki, Iivo; Heikkilä, Nelli; Peterson, Pärt; Kekäläinen, Eliisa; Willcox, Nick; Wolff, Anette Susanne Bøe; Jarva, Hanna; Arstila, T Petteri (Journal article; Peer reviewed, 2024)

  Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is an inborn error of immunity affecting both multiple endocrine organs and susceptibility to candidiasis, each with an autoimmune basis. Recently, ...

• Six-year follow-up of participants in two clinical trials of rituximab or cyclophosphamide in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome 

  Rekeland, Ingrid Gurvin; Sørland, Kari; Neteland, Lisbeth Lykke; Fosså, Alexander; Alme, Kine; Risa, Kristin; Dahl, Olav; Tronstad, Karl Johan; Mella, Olav; Fluge, Øystein (Journal article; Peer reviewed, 2024)

  Objectives In this six-year follow-up study, we used patient-reported outcome measures (PROMs) to compare values at baseline, at 18 months, and at six-year follow up from the CycloME and the RituxME trials. Methods Based ...

• Quantified planar collagen distribution in healthy and degenerative mitral valve: biomechanical and clinical implications 

  Sadeghinia, Mohammad Javad; Persson, Robert; Ellensen, Vegard Skalstad; Haaverstad, Rune; Holzapfel, Gerhard; Skallerud, Bjørn Helge; Prot, Victorien Emile; Urheim, Stig (Journal article; Peer reviewed, 2024)

  Degenerative mitral valve disease is a common valvular disease with two arguably distinct phenotypes: fibroelastic deficiency and Barlow’s disease. These phenotypes significantly alter the microstructures of the leaflets, ...

• Expiratory airflow limitation in adults born extremely preterm: A systematic review and meta-analysis 

  Lillebøe, Henriette Lahn-Johannessen; Engeseth, Merete Salveson; Clemm, Hege Synnøve Havstad; Halvorsen, Thomas; Røksund, Ola Drange; Potrebny, Thomas; Vollsæter, Maria (Journal article; Peer reviewed, 2024)

  Extreme preterm (EP) birth, denoting delivery before the onset of the third trimester, interrupts intrauterine development and causes significant early-life pulmonary trauma, thereby posing a lifelong risk to respiratory ...

• α1-Antichymotrypsin Complex (SERPINA3) Is an Independent Predictor of All-Cause but Not Cardiovascular Mortality in Patients Hospitalized for Chest Pain of Suspected Coronary Origin 

  Nilsen, Dennis WT; Aarsetøy, Reidun; Pønitz, Volker; Ueland, Thor; Aukrust, Pål; Michelsen, Annika Elisabet; Andersen, Trygve Brugger; Staines, Harry; Grundt, Heidi (Journal article; Peer reviewed, 2024)

  Introduction: SERPINA3 is an acute phase protein triggered by inflammation. It is upregulated after an acute myocardial infarction (AMI). Data on its long-term prognostic value in MI patients are scarce. We aimed to assess ...

• Monocytic Differentiation in Acute Myeloid Leukemia Cells: Diagnostic Criteria, Biological Heterogeneity, Mitochondrial Metabolism, Resistance to and Induction by Targeted Therapies 

  Bruserud, Øystein; Selheim, Frode; Valladares, Maria del Carmen Hernandez; Reikvam, Håkon (Journal article; Peer reviewed, 2024)

  We review the importance of monocytic differentiation and differentiation induction in non-APL (acute promyelocytic leukemia) variants of acute myeloid leukemia (AML), a malignancy characterized by proliferation of immature ...

• 'When age is not a barrier': an explorative study of nonagenarian patients' experiences of undergoing percutaneous coronary intervention 

  Instenes, Irene; Fridlund, Bengt Gotthard Anton; Borregaard, Britt; Larsen, Alf Inge; Allore, Heather; Bendz, Bjørn; Deaton, Christi; Rotevatn, Svein; Fålun, Nina Britt; Norekvål, Tone Merete (Journal article; Peer reviewed, 2024)

  Aims The recent rise in the number of nonagenarians (age ≥ 90 years) undergoing percutaneous coronary intervention (PCI) has revealed gaps in research, in particular on patients’ experiences. Therefore, the aim of the ...

• Time trends and birth rates in women with congenital heart disease; a nationwide cohort study from Norway 1994–2014 

  Sandberg, Marit; Fomina, Tatiana; Macsali, Ferenc; Greve, Gottfried; Estensen, Mette-Elise; Øyen, Nina; Leirgul, Elisabeth (Journal article; Peer reviewed, 2024)

  Background: More women with congenital heart disease (CHD) reach reproductive age, but little is known of their success in having children. We investigated time trends of CHD in women of reproductive age and maternal CHD ...

• Recurrent laryngeal nerve injury and nerve recovery evaluated by EMG, accelerometry and direct laryngoscopy : -An experimental approach - 

  Setså, Erling Johan (Doctoral thesis, 2024-12-13)

  Den mest fryktede komplikasjonen ved endokrinkirurgi på hals er bilateral skade på nervus laryngeus rekurrens (RLN) som kan føre til lammelse av stemmebåndene, ledsaget av alvorlige respirasjonsproblemer som kan ende i ...

• Lung function in Norway in the 20th century : Trends, lower limits of normality and overall and specific mortalities 

  Cestelli, Lucia (Doctoral thesis, 2024-12-06)

  Bakgrunn og mål: Lungefunksjon er en markør for generell helse og kan predikere mortalitet. Flere faktorer påvirker måling og tolkning av lungefunksjon i en befolkning. Målet med dette doktorgradsarbeidet var å studere den ...

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