Department of Clinical Science
Recent Submissions
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Metabolomics identifies placental dysfunction and confirms Flt-1 (FMS-like tyrosine kinase receptor 1) biomarker specificity
(Journal article; Peer reviewed, 2019)Clinical end-stage parameters define the pregnancy disorders preeclampsia and fetal growth restriction while classification of the underlying placental dysfunction is missing and urgently needed. Flt-1 (FMS-like tyrosine ... -
Tryptophan catabolites as metabolic markers of vitamin B-6 status evaluated in cohorts of healthy adults and cardiovascular patients
(Journal article; Peer reviewed, 2020)Background Vitamin B-6 status is routinely measured as pyridoxal 5′-phosphate (PLP) in plasma. Low concentrations of PLP are associated with rheumatic, cardiovascular, and neoplastic diseases. We have previously shown ... -
Studies on sequencing analyses of genetic and epigenetics features in melanoma and breast cancer
(Doctoral thesis, 2020-12-15)The dissertation includes 3 projects and in each work we applied different approaches to sequencing and bioinformatics analyses to gain a better understanding of the molecular characteristics of breast cancer and melanoma. ... -
Chronic obstructive pulmonary disease and risk of lung cancer
(Doctoral thesis, 2020-12-08)Abstract Background: Lung cancer is a main cause of death in patients suffering from COPD and smokers with COPD have an increased risk of lung cancer compared to healthy smokers. COPD comprises a broad range of features, ... -
Characterization of adipose tissue and liver innate immune cells in obesity-related insulin resistance
(Doctoral thesis, 2020-12-04)Obesity is a highly prevalent disease associated with a number of chronic and noncommunicable diseases including type 2 diabetes (T2D), nonalcoholic fatty liver disease (NAFLD), and cardiovascular disease (CVD). Obesity ... -
Cardiovascular risk markers in aortic valve stenosis : Insights in peak systolic left ventricular function, ejection dynamics and obesity
(Doctoral thesis, 2020-12-04)Background: Aortic valve stenosis (AS) is the most prevalent valvular heart disease requiring valvular intervention. With no pharmacological treatment available, optimal management requires detection of early left ventricular ... -
Predictors of underweight, overweight and obesity, and effect of treatment of obesity in early childhood
(Doctoral thesis, 2020-11-17)Abstract Background: The prevalence of overweight (OW) and obesity (OB) has escalated throughout the world over the last decades, both in children and adults. Childhood OB is a major risk factor for adult OB and the ... -
Towards stratification of patients with Sjögren’s syndrome : Single cell analyses and immune profiling
(Doctoral thesis, 2020-11-06)Primary Sjögren’s syndrome (pSS) is a systemic, chronic autoimmune disorder that is characterized by progressive lymphocytic infiltration in the exocrine glands i.e., the salivary and lacrimal glands, leading to immune-mediated ... -
Myocardial ischemia in non-obstructive coronary artery disease : Associations with coronary artery disease morphology and left ventricular hypertrophy
(Doctoral thesis, 2020-09-22)Background: The underlying mechanisms causing myocardial ischemia in non-obstructive coronary artery disease (CAD) are incompletely understood. We tested whether the total coronary artery plaque burden, coronary tortuosity ... -
Enhancement of iodinin solubility by encapsulation into cyclodextrin nanoparticles
(Journal article; Peer reviewed, 2018)Phenazine is known to regroup planar nitrogen-containing heterocyclic compounds. It was used here to enhance the bioavailability of the biologically important compound iodinin, which is near insoluble in aqueous solutions. ... -
Immunoregulatory networks in healthy adult allogeneic stem cell donors : Studies of peripheral hematopoietic stem cell donors and their recipients
(Doctoral thesis, 2020-10-28)Final outcome after allogeneic peripheral blood stem cell transplantation (PBSCT) is influenced by the high degrees of variation in disease and comorbidities among recipients, as well as the pre-and post-transplant handling ... -
Pubertal development in Norwegian girls
(Doctoral thesis, 2020-10-23)Background: Evidence suggests that girls worldwide are experiencing a decrease in age at pubertal onset, but data from Norwegian girls have not been available. Early pubertal timing is associated with adverse health ... -
Functional characterization of genetic risk factors in autoimmune Addison’s disease
(Doctoral thesis, 2020-10-23)Autoimmune diseases occur when the immune system attacks and damages the body’s own tissue. Why people develop these diseases, and how the autoimmune reaction develops are unanswered questions. Autoimmune Addison's disease ... -
Sleep habits and sleep problems among children born extremely preterm: A Norwegian population-based cohort study
(Doctoral thesis, 2020-10-09)Objective: The objective of this thesis was to investigate the prevalence of general and specified sleep problems during childhood and the sleep habits of children aged 11 years who had been born extremely preterm (EPT). ... -
Exploration of Cellular Signaling Patterns for the Stratification of Patients with Rheumatoid Arthritis
(Doctoral thesis, 2020-09-16)Introduction: Rheumatoid arthritis (RA) is a chronic inflammatory disease, characterized by synovial inflammation that, if not treated early and efficiently, causes joint damage. The proinflammatory cytokine tumor necrosis ... -
Cardiac Resynchronization Therapy (CRT): Patient Selection and Guideline Adherence : An Analysis of CRT Practice in Europe Based on the European Society of Cardiology CRT Survey II with 11088 patients in 42 countries.
(Doctoral thesis, 2020-09-04)Background/Aims Cardiac Resynchronization Therapy (CRT) reduces morbidity and mortality in patients with heart failure and electrical dyssynchrony. Recommendations for which patients should receive a CRT device are outlined ... -
Common nodes of virus-host interaction revealed through an integrated network analysis
(Peer reviewed; Journal article, 2019-10-04)Viruses are one of the major causes of acute and chronic infectious diseases and thus a major contributor to the global burden of disease. Several studies have shown how viruses have evolved to hijack basic cellular pathways ... -
Comparison of physical activity and body composition in a cohort of children born extremely preterm or with extremely low birth weight to matched term-born controls: a follow-up study
(Peer reviewed; Journal article, 2019)Objectives: To compare physical activity and body composition in a cohort of children born extremely preterm/extremely low birth weight (EP/ELBW) with term-born (TB) controls. Methods: A regional cohort of children born ... -
Bridging the evidence gap for implementing antibiotic stewardship in Norway: Interventions, process measures and patient outcomes related to antibiotic prescribing in hospitals
(Doctoral thesis, 2019-12-09)Background: Antimicrobial resistance is a major challenge for patient safety worldwide, as a growing number of infections become difficult to treat and the advances made in modern medicine are threatened. Overuse and misuse ... -
Coping with a disruptive life caused by obstetric fistula: Perspectives from Malawian women
(Peer reviewed; Journal article, 2019)Background: The main symptom of obstetric fistula is urinary and or fecal incontinence. Incontinence, regardless of the type is debilitating, socially isolating, and psychologically depressing. The objective of this study ...
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