Department of Clinical Science
Recent Submissions
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Interleukin-2 receptor in the pathogenesis of diabetic complications and Sjögren's syndrome
(Doctoral thesis, 2021-12-14)The cytokine interleukin-2 (IL-2) acts as a double-edged sword by promoting both immunity and immune tolerance. Regulatory T cells (Tregs) are responsible for maintaining self-tolerance and constitutively express the high ... -
Chip protein U-box domain truncation affects Purkinje neuron morphology and leads to behavioral changes in zebrafish
(Journal article; Peer reviewed, 2021-09-24)The ubiquitin ligase CHIP (C-terminus of Hsc70-interacting protein) is encoded by STUB1 and promotes ubiquitination of misfolded and damaged proteins. CHIP deficiency has been linked to several diseases, and mutations in ... -
Immunohistochemical biomarkers are prognostic relevant in addition to the ESMO-ESGO-ESTRO risk classification in endometrial cancer
(Journal article; Peer reviewed, 2021)Objective: Pre-operative immunohistochemical (IHC) biomarkers are not incorporated in endometrial cancer (EC) risk classification. We aim to investigate the added prognostic relevance of IHC biomarkers to the ESMO-ESGO-ESTRO ... -
Improved pH-Responsive Release of Phenformin from Low-Defect Graphene Compared to Graphene Oxide
(Journal article; Peer reviewed, 2021)Graphene-based drug carriers provide a promising addition to current cancer drug delivery options. Increased accessibility of high-quality graphene made by plasma-enhanced chemical vapor deposition (PE-CVD) makes it an ... -
A 10-gene prognostic signature points to LIMCH1 and HLA-DQB1 as important players in aggressive cervical cancer disease
(Journal article; Peer reviewed, 2021)Background: Advanced cervical cancer carries a particularly poor prognosis, and few treatment options exist. Identification of effective molecular markers is vital to improve the individualisation of treatment. We investigated ... -
Baked cod consumption delayed the development of kidney and liver dysfunction and affected plasma amino acid concentrations, but did not affect blood pressure, blood glucose or liver triacylglycerol concentrations in obese fa/fa Zucker rats.
(Journal article; Peer reviewed, 2021)Obesity is associated with changes in amino acid metabolism, and studies show that ingestion of fish proteins influence amino acid composition in plasma and urine, in addition to affecting risk factors for metabolic syndrome. ... -
Lower circulating neuron-specific enolase concentrations in adults and adolescents with severe mental illness
(Journal article; Peer reviewed, 2021)Background: Both neurodegenerative and neurodevelopmental abnormalities have been suggested to be part of the etiopathology of severe mental illness (SMI). Neuron-specific enolase (NSE), mainly located in the neuronal ... -
IL-18 and IL-18 binding protein are related to disease severity and parasitemia during falciparum malaria
(Journal article; Peer reviewed, 2021)Background: Several inflammatory molecules participate in the immune response to malaria. Interleukin (IL)-18 is an inflammatory cytokine activated by NLRP3 inflammasomes. In clinical falciparum malaria, with and without ... -
Novel neonatal simulator provides high-fidelity ventilation training comparable to real-life newborn ventilation
(Journal article; Peer reviewed, 2021)Face mask ventilation of apnoeic neonates is an essential skill. However, many non-paediatric healthcare personnel (HCP) in high-resource childbirth facilities receive little hands-on real-life practice. Simulation training ... -
Liquid Biopsies in Solid Cancers: Implementation in a Nordic Healthcare System
(Journal article; Peer reviewed, 2021)Liquid biopsies have emerged as a potential new diagnostic tool, providing detailed information relevant for characterization and treatment of solid cancers. We here present an overview of current evidence supporting the ... -
Meal patterns associated with energy intake in people with obesity
(Journal article; Peer reviewed, 2021)It is widely assumed that people with obesity have several common eating patterns, including breakfast-skipping (1), eating during the night (2) and high fast-food consumption (3). However, differences in individual meal ... -
The association between intrapartum opioid fentanyl and early breastfeeding: A prospective observational study
(Journal article; Peer reviewed, 2021)Introduction: Intrapartum opioids in labor may interfere with the early breastfeeding phase and cause breastfeeding difficulties. This study examines the effects of intrapartum fentanyl given intravenously (IV) or through ... -
Proteomic Comparison of Bone Marrow Derived Osteoblasts and Mesenchymal Stem Cells
(Journal article; Peer reviewed, 2021)Mesenchymal stem cells (MSCs) can differentiate into osteoblasts, and therapeutic targeting of these cells is considered both for malignant and non-malignant diseases. We analyzed global proteomic profiles for osteoblasts ... -
The Constitutive Extracellular Protein Release by Acute Myeloid Leukemia Cells—A Proteomic Study of Patient Heterogeneity and Its Modulation by Mesenchymal Stromal Cells
(Journal article; Peer reviewed, 2021)Extracellular protein release is important both for the formation of extracellular matrix and for communication between cells. We investigated the extracellular protein release by in vitro cultured normal mesenchymal stem ... -
Systemic inflammation in psoriasis: Circulating immune cells and cytokines
(Doctoral thesis, 2019-09-27)Psoriasis is a common, chronic inflammatory skin disease associated with arthritis and multiple comorbidities. Autoantigens in the skin elicit a response in cytotoxic T cells, leading to local inflammation and recruitment ... -
Fatigue in psoriasis: prevalence and biological mechanisms
(Doctoral thesis, 2021-06-18)Background: Fatigue is prevalent in patients with chronic inflammatory diseases and often rated as the most troublesome aspect of their disease. Clinical experience indicates that fatigue is common also in patients with ... -
Chronic obstructive pulmonary disease (COPD): exacerbations and costs.
(Doctoral thesis, 2021-10-27)Background: Chronic obstructive pulmonary disease (COPD) is a major contributor to morbidity and mortality worldwide. Being a preventable disease in most cases, the burden on both patients and society may be reduced ... -
Determinants of interindividual variation in exercise-induced cardiac troponin I levels
(Journal article; Peer reviewed, 2021)Background: Postexercise cardiac troponin levels show considerable interindividual variations. This study aimed to identify the major determinants of this postexercise variation in cardiac troponin I (cTnI) following 3 ... -
Tailoring NIV by dynamic laryngoscopy in a child with spinal muscular atrophy type I
(Journal article; Peer reviewed, 2021)Dynamic laryngoscopy during noninvasive (NIV) respiratory therapy is feasible and may facilitate optimal and individualized treatment in patients with chronic respiratory failure, also in children. -
Presence and effect of tumour biomarkers in a population-based series of metastatic colorectal cancer patients
(Doctoral thesis, 2021-10-22)Background: Colorectal cancer (CRC) is one of the most common malignancies worldwide, and a substantial group of patients will develop metastases. Survival for metastatic CRC (mCRC) has improved, but mainly for trial ...
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