Department of Clinical Science
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Factors that influence recruitment to COVID-19 vaccine trials: a qualitative evidence synthesis
(Journal article; Peer reviewed, 2024-12-19)Background: The COVID-19 pandemic marked a unique period characterised by an extraordinary global virus spread. The collective effort to halt the transmission of the virus led to various public health initiatives, including ... -
Alterations of lipid homeostasis in morbid obese patients are partly reversed by bariatric surgery
(Journal article; Peer reviewed, 2024)Besides its beneficial effect on weight loss, gastric bypass surgery (GBS) may impact the circulating levels of phospho- and sphingolipids. However, long-term effects have not been explored. To investigate alterations in ... -
The GLI code controls HNF1A levels during foregut differentiation
(Journal article; Peer reviewed, 2024)Differentiation of human induced pluripotent stem cells towards pancreatic islet endocrine cells is a complex process, involving the stepwise modulation of key developmental pathways, such as the Hedgehog signaling inhibition ... -
Anafylaksi utløst av alfa-gal-allergi
(Journal article; Peer reviewed, 2024)Denne kasuistikken beskriver en anafylaksi utløst av alfa-gal-allergi. Anamnestiske opplysninger om kombinasjonen av tidligere flåttbitt og nylig inntak av rødt kjøtt var avgjørende for supplerende blodprøvetaking og rett ... -
A speech therapy treatment protocol for exercise induced laryngeal obstruction
(Journal article; Peer reviewed, 2024)Background: Exercise induced laryngeal obstruction (EILO) is a common cause of exertional breathing problems in young individuals, relevant to 5%–7% of young people. It is caused by paradoxical inspiratory adduction of ... -
Childbearing in women with congenital heart disease : A nationwide cohort study from Norway 1994-2014
(Doctoral thesis, 2025-03-21)Bakgrunn: Forekomsten av medfødt hjertefeil hos voksne øker på grunn av bedret diagnostikk for å oppdage milde hjertefeil, samt medisinske og kirurgiske fremskritt som har økt overlevelsen for personer med alvorlige ... -
Patient-derived acellular ascites fluid affects drug responses in ovarian cancer cell lines through the activation of key signalling pathways
(Journal article; Peer reviewed, 2025)Malignant ascites is commonly produced in advanced epithelial ovarian cancer (EOC) and serves as unique microenvironment for tumour cells. Acellular ascites fluid (AAF) is rich in signalling molecules and has been proposed ... -
Associations between non-registered ultrasound examination in pregnancy and adverse perinatal outcomes in immigrant and non-immigrant women: a Norwegian population-based study 1999–2016
(Journal article; Peer reviewed, 2024)Background: Prenatal ultrasound examinations are important to detect placental dysfunction. Several ultrasound-detected abnormalities can be managed during pregnancy or childbirth, thus improve health outcomes. Maternal ... -
Gut microbiota patterns associated with duration of diarrhea in children under five years of age in Ethiopia
(Journal article; Peer reviewed, 2024)Diarrhea claims >500,000 lives annually among children under five years of age in low- and middle-income countries. Mortality due to acute diarrhea (<7 days’ duration) is decreasing, but prolonged (7-13 days) and persistent ... -
Pediatric Diabetes Care in Norway : Glycemic Results and Health-Related Quality of Life
(Doctoral thesis, 2025-03-17)Bakgrunn I Norge har det blitt gjort en rekke tiltak for å forbedre pediatriske diabetesomsorgen og for å følge opp barn med diabetes på best mulig måte. I tillegg til å ta tidlig i bruk ny diabetesteknologi, har norsk ... -
High-dimensional single-cell analysis of human natural killer cell heterogeneity
(Journal article; Peer reviewed, 2024)Natural killer (NK) cells are innate lymphoid cells (ILCs) contributing to immune responses to microbes and tumors. Historically, their classification hinged on a limited array of surface protein markers. Here, we used ... -
The Rac1-inhibitor EHop-016 attenuates AML cell migration and enhances the efficacy of daunorubicin in MOLM-13 transplanted zebrafish larvae
(Journal article; Peer reviewed, 2024)Ras-related C3 botulinum toxin substrate 1 (Rac1) is a GTPase implicated in cell migration and homing of hematopoietic cells to the hematopoietic niche, and is commonly overexpressed in acute myeloid leukemia (AML). This ... -
Glucose Concentration in Regulating Induced Pluripotent Stem Cells Differentiation Toward Insulin-Producing Cells
(Journal article; Peer reviewed, 2024)The generation of insulin-producing cells from human-induced pluripotent stem cells holds great potential for diabetes modeling and treatment. However, existing protocols typically involve incubating cells with un-physiologically ... -
A phase III, open-label clinical trial evaluating pegunigalsidase alfa administered every 4 weeks in adults with Fabry disease previously treated with other enzyme replacement therapies
(Journal article; Peer reviewed, 2024)Pegunigalsidase alfa, a PEGylated α-galactosidase A enzyme replacement therapy (ERT) for Fabry disease, has a longer plasma half-life than other ERTs administered intravenously every 2 weeks (E2W). BRIGHT (NCT03180840) was ... -
Three doses of Sars-CoV-2 mRNA vaccine in older adults result in similar antibody responses but reduced cellular cytokine responses relative to younger adults
(Journal article; Peer reviewed, 2024)Objectives Booster COVID-19 vaccinations are used to protect the elderly, a group vulnerable to severe disease. We compared humoral and cellular immunity in older versus younger adults up to eight months after administering ... -
Impact of ageing on homologous and human-coronavirus-reactive antibodies after SARS-CoV-2 vaccination or infection
(Journal article; Peer reviewed, 2024)The endemic human coronaviruses (HCoVs) circulate worldwide yet remain understudied and unmitigated. The observation of elevated levels of HCoV reactive antibodies in COVID-19 patients highlights the urgent necessity of ... -
Pasienttilstrøyming til akuttmottak ved to norske universitetssjukehus i 2012–21
(Journal article; Peer reviewed, 2024)Bakgrunn Auking av pasientar til akuttmottaka er ei global utfordring. Vi ønskte å kartleggje pasienttilstrøyming og pasientsamansetning over tid ved to norske universitetssjukehus. Materiale og metode Retrospektiv, ... -
Protocol for the development of a core outcome set for clinical trials in primary sclerosing cholangitis
(Journal article; Peer reviewed, 2024)Background Primary sclerosing cholangitis (PSC) is a progressive immune-mediated liver disease, for which no medical therapy has been shown to slow disease progression. However, the horizon for new therapies is encouraging, ... -
Ein mann i 60-åra med livstrugande febersjukdom etter utanlandsreise
(Journal article; Peer reviewed, 2024)Ein mann i 60-åra var på arbeidsopphald i eit austafrikansk land då han ein dag følte seg allment sjuk og slapp med feber. Han avbraut opphaldet, flaug heim til Noreg og blei lagt inn like etter heimkomst med feber og ...
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