Department of Clinical Science
Nye registreringer
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Ultrasensitive Assays for Targeted Breast Cancer Treatment
(Doctoral thesis, 2025-01-23)Den avgjørende rollen til østrogen i østrogenreseptor-positiv (ER+) brystkreft er veletablert, hvor aromatasehemmere som hemmer østrogensyntesen er sentral i behandlingen av brystkreft. Imidlertid er kvantifiseringen av ... -
Use of health services and perceived need for information and follow-up after percutaneous coronary intervention
(Journal article; Peer reviewed, 2024-01-05)Objective Few patients achieve full control of their coronary artery disease (CAD) risk factors. Follow-up, such as cardiac rehabilitation, is important to increase adherence to lifestyle changes and treatment, to improve ... -
Assessment of Variables Related to the Risk of Severe Adverse Events in Cutaneous Melanoma Patients Treated with Immune Checkpoint Inhibitors
(Journal article; Peer reviewed, 2024)Malignant melanoma is a prevalent and aggressive cancer, with globally increasing incidences. While immune checkpoint inhibitors (ICIs) have prolonged the survival of patients with advanced melanoma over the last decade, ... -
Compositional plaque progression in women and men with non-obstructive coronary artery disease
(Journal article; Peer reviewed, 2024)Background: In coronary artery disease (CAD), plaque progression and plaque composition are associated with cardiovascular risk. Whether compositional plaque progression in non-obstructive CAD differs between women and men ... -
Measuring pain intensity through physical interaction in an experimental model of cold-induced pain: A method comparison study
(Journal article; Peer reviewed, 2024)Objectives: Assessment of pain is challenging given its subjective nature. Standard pain assessment tools have limitations. We aimed to compare the verbal numeric rating scale (NRS) and Grasp, a novel handheld electronic ... -
Muscle Strength and Male Sexual Function
(Journal article; Peer reviewed, 2024-01-12)Sexual dysfunction, in particular erectile dysfunction, is a common complaint among aging men. Obesity, diabetes, hypertension, and smoking are shown to be independent risk factors for erectile dysfunction, while ... -
Factors associated with progression of arterial stiffness in ischemic stroke survivors: the Norwegian Stroke in the Young Study
(Journal article; Peer reviewed, 2024)Background: Progressive arterial stiffening may increase the risk of recurrent cardiovascular events in ischemic stroke survivors. Information about factors associated with progressive arterial stiffening during the follow-up ... -
Molecular profiling of NOD mouse islets reveals a novel regulator of insulitis onset
(Journal article; Peer reviewed, 2024)Non-obese diabetes (NOD) mice are an established, spontaneous model of type 1 diabetes in which diabetes develops through insulitis. Using next-generation sequencing, coupled with pathway analysis, the molecular fingerprint ... -
Concentrated transdiagnostic and cross-disciplinary micro-choice based group treatment for patients with depression and with anxiety leads to lasting improvements after 12 months: a pilot study
(Journal article; Peer reviewed, 2024)Background A concentrated transdiagnostic and micro choice-based group treatment for patients with depression and anxiety has previously shown to yield significant reduction in symptoms and increased level of functioning ... -
Bioinformatics pipeline for the systematic mining genomic and proteomic variation linked to rare diseases: The example of monogenic diabetes
(Journal article; Peer reviewed, 2024)Monogenic diabetes is characterized as a group of diseases caused by rare variants in single genes. Like for other rare diseases, multiple genes have been linked to monogenic diabetes with different measures of pathogenicity, ... -
Association of Left Atrial Stiffness With Risk of Cryptogenic Ischemic Stroke in Young Adults
(Journal article; Peer reviewed, 2024)Background Incidence of cryptogenic ischemic stroke (CIS) in young adults is increasing. Early left atrial (LA) myopathy might be 1 of the underlying mechanisms, but this has only been scarcely explored. Objectives The ... -
Effects of relaxation interventions during pregnancy on maternal mental health, and pregnancy and newborn outcomes: A systematic review and meta-analysis
(Journal article; Peer reviewed, 2024)Background Stress during pregnancy is detrimental to maternal health, pregnancy and birth outcomes and various preventive relaxation interventions have been developed. This systematic review and meta-analysis aimed to ... -
Mass cytometric single cell immune profiles of peripheral blood from acute myeloid leukemia patients in complete remission with measurable residual disease
(Journal article; Peer reviewed, 2024)Measurable residual disease (MRD) is detected in approximately a quarter of AML chemotherapy responders, serving as a predictor for relapse and shorter survival. Immunological control of residual disease is suggested to ... -
Considerations for the design and conduct of pediatric obesity pharmacotherapy clinical trials: Proceedings of expert roundtable meetings
(Journal article; Peer reviewed, 2024)Anti-obesity medications (AOMs) have emerged as one element of comprehensive obesity clinical care intended to improve long-term health outcomes for children and adolescents. The number of pediatric AOM clinical trials has ... -
Complete response of metastatic microsatellite-stable BRAF V600E colorectal cancer to first-line oxaliplatin-based chemotherapy and immune checkpoint blockade
(Journal article; Peer reviewed, 2024)The randomized METIMMOX trial (NCT03388190) examined if patients with previously untreated, unresectable abdominal metastases from microsatellite-stable (MSS) colorectal cancer (CRC) might benefit from potentially immunogenic, ... -
Radiomic profiles improve prognostication and reveal targets for therapy in cervical cancer
(Journal article; Peer reviewed, 2024)Cervical cancer (CC) is a major global health problem with 570,000 new cases and 266,000 deaths annually. Prognosis is poor for advanced stage disease, and few effective treatments exist. Preoperative diagnostic imaging ... -
Exploring virtual delivery of academic detailing to general practitioners compared with in-person delivery: a qualitative study
(Journal article; Peer reviewed, 2024)Background Inappropriate prescribing may have detrimental consequences for the patient and increase healthcare utilisation and costs. Academic detailing (AD) is an interactive outreach method to deliver non-commercial ... -
Longitudinal investigation of a single variant SARS-CoV-2-outbreak in the immunologically naïve population of Ulvik, Norway
(Journal article; Peer reviewed, 2024)Purpose To perform an extensive investigation of the clinical features and long-term complications among the n = 134 adults and children with nucleic acid amplification test (NAAT) verified SARS-CoV-2-infection in the ... -
Likely causal effects of insulin resistance and IGF-1 bioaction on childhood and adult adiposity: a Mendelian randomization study
(Journal article; Peer reviewed, 2024)Background Circulating insulin and insulin-like growth factor-1 (IGF-1) concentrations are positively correlated with adiposity. However, the causal effects of insulin and IGF-1 on adiposity are unclear. Methods We ... -
Outpatient parenteral antimicrobial therapy (OPAT) using a continuous ambulatory delivery device (CADD) allowing treatment with multiple daily doses: a brief report of a Norwegian experience
(Journal article; Peer reviewed, 2024)Background Outpatient parenteral antimicrobial therapy (OPAT) is safe, effective and increasingly available. While OPAT in Norwegian healthcare has been rare, a new continuous ambulatory delivery device (CADD) allowing ...
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