Department of Clinical Science
Recent Submissions
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Islet autoantibodies as precision diagnostic tools to characterize heterogeneity in type 1 diabetes: a systematic review
(Journal article; Peer reviewed, 2024)Background Islet autoantibodies form the foundation for type 1 diabetes (T1D) diagnosis and staging, but heterogeneity exists in T1D development and presentation. We hypothesized that autoantibodies can identify ... -
Clinical utility of novel diabetes subgroups in predicting vascular complications and mortality: up to 25 years of follow-up of the HUNT Study
(Journal article; Peer reviewed, 2024)Introduction Cluster analysis has previously revealed five reproducible subgroups of diabetes, differing in risks of diabetic complications. We aimed to examine the clusters’ predictive ability for vascular complications ... -
Clinical and imaging characteristics of patients with cardiac amyloidosis- a single center observational study
(Journal article; Peer reviewed, 2024)Amyloidosis is a disease characterized by the deposition of protein fibrils. Cardiac involvement is a significant factor in determining prognosis. This study aimed to examine the clinical profile, outcomes, and long-term ... -
Immune cell activity during anti-TNF treatment in patients with psoriasis and psoriatic arthritis
(Journal article; Peer reviewed, 2024)Psoriasis is a chronic, inflammatory skin disease characterized by a dysregulated immune response and systemic inflammation. Up to one-third of patients with psoriasis have psoriatic arthritis (PsA). Targeted treatment ... -
Development of selective ssDNA micro-probe for PD1 detection as a novel strategy for cancer imaging
(Journal article; Peer reviewed, 2024)Programmed death receptor 1, PD1, modulates the function of immune cells by providing inhibitory signals and constitutes the marker of immune exhaustion. Monitoring the level of PD1 promises a useful diagnostic approach ... -
Discharge Information About Adverse Drug Reactions Indicates Lower Self-Reported Adverse Drug Reactions and Fewer Concerns in Patients After Percutaneous Coronary Intervention
(Journal article; Peer reviewed, 2024)Aim There are discrepancies between the information patients desire about adverse drug reactions (ADRs) and the information they receive from healthcare providers; this is an impediment to shared decision-making. This study ... -
Obstetric infections and clinical characteristics of maternal sepsis: a hospital-based retrospective cohort study
(Journal article; Peer reviewed, 2024)Sepsis is responsible for 50% of intrahospital maternal deaths worldwide. Incidence is increasing in both low and middle-, and high-income countries. There is little data on incidence and clinical outcomes of obstetric ... -
Elastic Bands Improve Oral Appliance Treatment Effect on Obstructive Sleep Apnoea: A Randomised Crossover Trial
(Journal article; Peer reviewed, 2024)Background Oral appliances (OAs) that limit mouth opening during sleep, such as monobloc appliances, have shown superior treatment effects in subgroups of patients with obstructive sleep apnoea. The application of elastic ... -
Toxoplasma gondii infection associated with inflammasome activation and neuronal injury
(Journal article; Peer reviewed, 2024)Toxoplasma gondii (TOXO) infection typically results in chronic latency due to its ability to form cysts in the brain and other organs. Latent toxoplasmosis could promote innate immune responses and impact brain function. ... -
Randomized clinical trial to assess whether the duration of cotrimoxazole preventive therapy in HIV patients with CD4 counts >350 CD4 cells/μL by antiretroviral treatment influences the rate of carriage of multidrug-resistant bacteria. Study protocol
(Report, 2016-09-20)Cotrimoxazole preventive therapy (CPT) is recommended for prevention of morbidity and mortality due to Pneumocystis jirovecii pneumonia (PJP) and other infections in HIV positive patients with low immunity. In industrial ... -
Nekrotiserende bløtdelsinfeksjoner
(Journal article; Peer reviewed, 2024)Nekrotiserende bløtdelsinfeksjoner rammer hud, subkutant vev, overfladisk fascie, dyp fascie eller muskulatur. Infeksjonene er alvorlige, sprer seg hurtig og kan medføre omfattende vevstap. De er sjeldne, men har høy ... -
'If you've lost your personality, there's no point in changing the valve'-a qualitative study of older adults' attitudes towards treatment of aortic stenosis with comorbid dementia
(Journal article; Peer reviewed, 2024)Objectives Due to prognostic uncertainty and limited decision-making capacity, the choice to perform transcatheter aortic valve implantation (TAVI) in patients with severe aortic stenosis (AS) and comorbid dementia is ... -
Pre-pregnancy obesity among immigrant and non-immigrant women in Norway: Prevalence, trends, and subgroup variations
(Journal article; Peer reviewed, 2024)Introduction This study assessed prevalence and time trends of pre-pregnancy obesity in immigrant and non-immigrant women in Norway and explored the impact of immigrants' length of residence on pre-pregnancy obesity ... -
Rare copy number variant analysis in case–control studies using snp array data: a scalable and automated data analysis pipeline
(Journal article; Peer reviewed, 2024)Background Rare copy number variants (CNVs) significantly influence the human genome and may contribute to disease susceptibility. High-throughput SNP genotyping platforms provide data that can be used for CNV detection, ... -
An experimental study on intraoperative recovery of recurrent laryngeal nerve function
(Journal article; Peer reviewed, 2020)Objective If bilateral thyroid surgery is planned and staged thyroidectomy considered in case of loss of neuromonitoring signal (LOS), a waiting time of 20 minutes is suggested for evaluation of early nerve recovery. This ... -
Genome-wide analyses of neonatal jaundice reveal a marked departure from adult bilirubin metabolism
(Journal article; Peer reviewed, 2024)Jaundice affects almost all neonates in their first days of life and is caused by the accumulation of bilirubin. Although the core biochemistry of bilirubin metabolism is well understood, it is not clear why some neonates ... -
Impact of the Graphene Production Methods Sonication and Microfluidization on In Vitro and In Vivo Toxicity, Macrophage Response, and Complement Activation
(Journal article; Peer reviewed, 2024)Graphene, a material composed of a two-dimensional lattice of carbon atoms, has due to its many unique properties a wide array of potential applications in the biomedical field. One of the most common production methods ... -
Exposure to Per- and Polyfluoroalkyl Substances and Timing of Puberty in Norwegian Boys: Data from the Bergen Growth Study 2
(Journal article; Peer reviewed, 2024)Per- and polyfluoroalkyl substances (PFAS) are widespread environmental contaminants with endocrine-disruptive properties. Their impact on puberty in boys is unclear. In this cross-sectional study, we investigated the ... -
No signs of mast cell involvement in long-COVID: A case–control study
(Journal article; Peer reviewed, 2024)Long-COVID caused by SARS-CoV-2 infection has significant and increasing effects on human health worldwide. Although a unifying molecular or biological explanation is lacking, several pathophysiological mechanisms have ...