• Ultrasensitive Assays for Targeted Breast Cancer Treatment 

  Bertelsen, Bjørn-Erik (Doctoral thesis, 2025-01-23)

  Den avgjørende rollen til østrogen i østrogenreseptor-positiv (ER+) brystkreft er veletablert, hvor aromatasehemmere som hemmer østrogensyntesen er sentral i behandlingen av brystkreft. Imidlertid er kvantifiseringen av ...

• Use of health services and perceived need for information and follow-up after percutaneous coronary intervention 

  Hjertvikrem, Nina; Brørs, Gunhild; Instenes, Irene; Helmark, Charlotte; Pettersen, Trond Røed; Rotevatn, Svein; Zwisler, Ann Dorthe O.; Norekvål, Tone Merete (Journal article; Peer reviewed, 2024-01-05)

  Objective Few patients achieve full control of their coronary artery disease (CAD) risk factors. Follow-up, such as cardiac rehabilitation, is important to increase adherence to lifestyle changes and treatment, to improve ...

• Assessment of Variables Related to the Risk of Severe Adverse Events in Cutaneous Melanoma Patients Treated with Immune Checkpoint Inhibitors 

  Trichkova, Kremena Petrova; Görtler, Franziska Stilla Maria; Bjørge, Line; Schuster, Cornelia (Journal article; Peer reviewed, 2024)

  Malignant melanoma is a prevalent and aggressive cancer, with globally increasing incidences. While immune checkpoint inhibitors (ICIs) have prolonged the survival of patients with advanced melanoma over the last decade, ...

• Compositional plaque progression in women and men with non-obstructive coronary artery disease 

  Hondros, Caroline Annette Berge; Khan, Ingela; Solvik, Margrete; Hanseth, Silja; Pedersen, Eva Ringdal; Hovland, Siren; Larsen, Terje Hjalmar; Lønnebakken, Mai Tone (Journal article; Peer reviewed, 2024)

  Background: In coronary artery disease (CAD), plaque progression and plaque composition are associated with cardiovascular risk. Whether compositional plaque progression in non-obstructive CAD differs between women and men ...

• Measuring pain intensity through physical interaction in an experimental model of cold-induced pain: A method comparison study 

  Rotevatn, Elisabeth Ørskov; Engan, Mette; Stensaker, Emilie; Hufthammer, Karl Ove; Rygh, Lars Jørgen (Journal article; Peer reviewed, 2024)

  Objectives: Assessment of pain is challenging given its subjective nature. Standard pain assessment tools have limitations. We aimed to compare the verbal numeric rating scale (NRS) and Grasp, a novel handheld electronic ...

• Muscle Strength and Male Sexual Function 

  Viken, Anders Flataker; Siiak, Silver Peeter; Schlünssen, Vivi; Thorarinsdottir, Elin Helga; Skulstad, Svein Magne; Gyawali, Sanjay; Bertelsen, Randi Jacobsen; Gomez Real, Francisco (Journal article; Peer reviewed, 2024-01-12)

  Sexual dysfunction, in particular erectile dysfunction, is a common complaint among aging men. Obesity, diabetes, hypertension, and smoking are shown to be independent risk factors for erectile dysfunction, while ...

• Factors associated with progression of arterial stiffness in ischemic stroke survivors: the Norwegian Stroke in the Young Study 

  Eilertsen, Rune Krogh; Midtbø, Helga Bergljot; Sindre, Rasmus Bach; Waje-Andreassen, Ulrike; Gerdts, Eva (Journal article; Peer reviewed, 2024)

  Background: Progressive arterial stiffening may increase the risk of recurrent cardiovascular events in ischemic stroke survivors. Information about factors associated with progressive arterial stiffening during the follow-up ...

• Molecular profiling of NOD mouse islets reveals a novel regulator of insulitis onset 

  Mathisen, Andreas Frøslev; Vacaru, Andrei Mircea; Unger, Lucas; Lamba, Elena Mirela; Mardare, Oana-Ana-Maria; Daian, Laura Maria; Ghila, Luiza Mihaela; Vacaru, Ana-Maria; Chera, Simona (Journal article; Peer reviewed, 2024)

  Non-obese diabetes (NOD) mice are an established, spontaneous model of type 1 diabetes in which diabetes develops through insulitis. Using next-generation sequencing, coupled with pathway analysis, the molecular fingerprint ...

• Concentrated transdiagnostic and cross-disciplinary micro-choice based group treatment for patients with depression and with anxiety leads to lasting improvements after 12 months: a pilot study 

  Wilhelmsen-Langeland, Ane; Børtveit, Tore; Jürgensen, Marte; Søfteland, Eirik; Hystad, Sigurd William; Kvale, Gerd (Journal article; Peer reviewed, 2024)

  Background A concentrated transdiagnostic and micro choice-based group treatment for patients with depression and anxiety has previously shown to yield significant reduction in symptoms and increased level of functioning ...

• Bioinformatics pipeline for the systematic mining genomic and proteomic variation linked to rare diseases: The example of monogenic diabetes 

  Kuznetsova, Ksenia; Vasicek, Jakub; Skiadopoulou, Dafni; Molnes, Janne; Udler, Miriam; Johansson, Stefan; Njølstad, Pål Rasmus; Manning, Alisa; Vaudel, Marc (Journal article; Peer reviewed, 2024)

  Monogenic diabetes is characterized as a group of diseases caused by rare variants in single genes. Like for other rare diseases, multiple genes have been linked to monogenic diabetes with different measures of pathogenicity, ...

• Association of Left Atrial Stiffness With Risk of Cryptogenic Ischemic Stroke in Young Adults 

  Sindre, Rasmus Bach; Gerdts, Eva; Putaala, Jukka; Grymyr, Lisa Marie Dale; Midtbø, Helga Bergljot; Almeida, Ana G.; Bech-Hanssen, Odd; Busch, Raila; Eilertsen, Rune Krogh; Fonseca, Ana Catarina; Hedman, Marja; Huhtakangas, Juha; Jäkälä, Pekka; Lautamäki, Riikka; Lehto, Mika; Martinez-Majander, Nicolas; Redfors, Petra; Sarkanen, Tomi; von Sarnowski, Bettina; Sinisalo, Juha; Virtanen, Marko; Waje-Andreassen, Ulrike; Yesilot, Nilufer; Ylikotila, Pauli; Cramariuc, Dana (Journal article; Peer reviewed, 2024)

  Background Incidence of cryptogenic ischemic stroke (CIS) in young adults is increasing. Early left atrial (LA) myopathy might be 1 of the underlying mechanisms, but this has only been scarcely explored. Objectives The ...

• Effects of relaxation interventions during pregnancy on maternal mental health, and pregnancy and newborn outcomes: A systematic review and meta-analysis 

  Abera, Mubarek; Hanlon, Charlotte; Daniel, Beniam; Tesfaye, Markos; Workicho, Abdulhalik; Girma, Tsinuel; Wibaek, Rasmus; Andersen, Gregers S.; Fewtrell, Mary; Filteau, Suzanne; Wells, Jonathan C.K. (Journal article; Peer reviewed, 2024)

  Background Stress during pregnancy is detrimental to maternal health, pregnancy and birth outcomes and various preventive relaxation interventions have been developed. This systematic review and meta-analysis aimed to ...

• Mass cytometric single cell immune profiles of peripheral blood from acute myeloid leukemia patients in complete remission with measurable residual disease 

  Sefland, Øystein; Gullaksen, Stein-Erik; Omsland, Maria; Reikvam, Håkon; Galteland, Eivind; Tran, Hoa Thi Tuyet; Spetalen, Signe; Singh, Satwinder Kaur; Van Zeeburg, Hester J. T.; Van De Loosdrecht, Arjan A.; Gjertsen, Bjørn Tore (Journal article; Peer reviewed, 2024)

  Measurable residual disease (MRD) is detected in approximately a quarter of AML chemotherapy responders, serving as a predictor for relapse and shorter survival. Immunological control of residual disease is suggested to ...

• Considerations for the design and conduct of pediatric obesity pharmacotherapy clinical trials: Proceedings of expert roundtable meetings 

  Kelly, Aaron S.; Bahlke, Melanie; Baker, Jennifer L.; de Beaufort, Carine; Belin, Ruth M.; Fonseca, Helena; Hale, Paula M.; Holm, Jens-Christian; Hsia, Daniel S.; Jastreboff, Ania M.; Juliusson, Pétur Benedikt; Murphy, Madhumita; Pak, Jonathan; Paul, Elizabeth; Rudolph, Bryan; Srivastava, Gitanjali; Tornøe, Christoffer W.; Weghuber, Daniel; Fox, Claudia K. (Journal article; Peer reviewed, 2024)

  Anti-obesity medications (AOMs) have emerged as one element of comprehensive obesity clinical care intended to improve long-term health outcomes for children and adolescents. The number of pediatric AOM clinical trials has ...

• Complete response of metastatic microsatellite-stable BRAF V600E colorectal cancer to first-line oxaliplatin-based chemotherapy and immune checkpoint blockade 

  Ree, Anne Hansen; Høye, Eirik; Esbensen, Qin Ying; Røberg Beitnes, Ann-Christin; Negård, Anne; Bernklev, Linn; Tetlie, Linn Kruse; Fretland, Åsmund Avdem; Hamre, Hanne Mari; Kersten, Christian; Hofsli, Eva; Guren, Marianne; Sorbye, Halfdan; Nilsen, Hilde; Flatmark, Kjersti; Meltzer, Sebastian (Journal article; Peer reviewed, 2024)

  The randomized METIMMOX trial (NCT03388190) examined if patients with previously untreated, unresectable abdominal metastases from microsatellite-stable (MSS) colorectal cancer (CRC) might benefit from potentially immunogenic, ...

• Radiomic profiles improve prognostication and reveal targets for therapy in cervical cancer 

  Halle, Mari Kyllesø; Hodneland, Erlend; Wagner-Larsen, Kari Strøno; Lura, Njål; Fasmer, Kristine Eldevik; Berg, Hege Fredriksen; Stokowy, Tomasz; Srivastava, Aashish; Forsse, David Erik; Høivik, Erling André; Woie, Kathrine; Bertelsen, Bjørn; Krakstad, Camilla; Haldorsen, Ingfrid S. (Journal article; Peer reviewed, 2024)

  Cervical cancer (CC) is a major global health problem with 570,000 new cases and 266,000 deaths annually. Prognosis is poor for advanced stage disease, and few effective treatments exist. Preoperative diagnostic imaging ...

• Exploring virtual delivery of academic detailing to general practitioners compared with in-person delivery: a qualitative study 

  Garcia, Beate Hennie; Langaas, Harald Chr.; Jahnsen, Jan Anker; Schjøtt, Jan Didrik; Nilsen, Terje; Lehnbom, Elin Christina (Journal article; Peer reviewed, 2024)

  Background Inappropriate prescribing may have detrimental consequences for the patient and increase healthcare utilisation and costs. Academic detailing (AD) is an interactive outreach method to deliver non-commercial ...

• Longitudinal investigation of a single variant SARS-CoV-2-outbreak in the immunologically naïve population of Ulvik, Norway 

  Mortensen, Nicolay; Wensaas, Knut-Arne; Solem, Unni; Sivertsen, Audun; Grewal, Harleen; Rørtveit, Guri; Ulvestad, Elling; Litleskare, Sverre (Journal article; Peer reviewed, 2024)

  Purpose To perform an extensive investigation of the clinical features and long-term complications among the n = 134 adults and children with nucleic acid amplification test (NAAT) verified SARS-CoV-2-infection in the ...

• Likely causal effects of insulin resistance and IGF-1 bioaction on childhood and adult adiposity: a Mendelian randomization study 

  Olwi, Duaa I.; Kaisinger, Lena R.; Kentistou, Katherine A.; Vaudel, Marc; Stankovic, Stasa; Njølstad, Pål Rasmus; Johansson, Stefan; Perry, John R. B.; Day, Felix R.; Ong, Ken K. (Journal article; Peer reviewed, 2024)

  Background Circulating insulin and insulin-like growth factor-1 (IGF-1) concentrations are positively correlated with adiposity. However, the causal effects of insulin and IGF-1 on adiposity are unclear. Methods We ...

• Outpatient parenteral antimicrobial therapy (OPAT) using a continuous ambulatory delivery device (CADD) allowing treatment with multiple daily doses: a brief report of a Norwegian experience 

  Skogen, Vegard; Helleren, Rita; Jacobsen, Marianne Giske; Opsal, Anne; Gallefoss, Frode (Journal article; Peer reviewed, 2024)

  Background Outpatient parenteral antimicrobial therapy (OPAT) is safe, effective and increasingly available. While OPAT in Norwegian healthcare has been rare, a new continuous ambulatory delivery device (CADD) allowing ...

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