• α1-Antichymotrypsin Complex (SERPINA3) Is an Independent Predictor of All-Cause but Not Cardiovascular Mortality in Patients Hospitalized for Chest Pain of Suspected Coronary Origin 

  Nilsen, Dennis WT; Aarsetøy, Reidun; Pønitz, Volker; Ueland, Thor; Aukrust, Pål; Michelsen, Annika Elisabet; Andersen, Trygve Brugger; Staines, Harry; Grundt, Heidi (Journal article; Peer reviewed, 2024)

  Introduction: SERPINA3 is an acute phase protein triggered by inflammation. It is upregulated after an acute myocardial infarction (AMI). Data on its long-term prognostic value in MI patients are scarce. We aimed to assess ...

• Monocytic Differentiation in Acute Myeloid Leukemia Cells: Diagnostic Criteria, Biological Heterogeneity, Mitochondrial Metabolism, Resistance to and Induction by Targeted Therapies 

  Bruserud, Øystein; Selheim, Frode; Valladares, Maria del Carmen Hernandez; Reikvam, Håkon (Journal article; Peer reviewed, 2024)

  We review the importance of monocytic differentiation and differentiation induction in non-APL (acute promyelocytic leukemia) variants of acute myeloid leukemia (AML), a malignancy characterized by proliferation of immature ...

• 'When age is not a barrier': an explorative study of nonagenarian patients' experiences of undergoing percutaneous coronary intervention 

  Instenes, Irene; Fridlund, Bengt Gotthard Anton; Borregaard, Britt; Larsen, Alf Inge; Allore, Heather; Bendz, Bjørn; Deaton, Christi; Rotevatn, Svein; Fålun, Nina Britt; Norekvål, Tone Merete (Journal article; Peer reviewed, 2024)

  Aims The recent rise in the number of nonagenarians (age ≥ 90 years) undergoing percutaneous coronary intervention (PCI) has revealed gaps in research, in particular on patients’ experiences. Therefore, the aim of the ...

• Time trends and birth rates in women with congenital heart disease; a nationwide cohort study from Norway 1994–2014 

  Sandberg, Marit; Fomina, Tatiana; Macsali, Ferenc; Greve, Gottfried; Estensen, Mette-Elise; Øyen, Nina; Leirgul, Elisabeth (Journal article; Peer reviewed, 2024)

  Background: More women with congenital heart disease (CHD) reach reproductive age, but little is known of their success in having children. We investigated time trends of CHD in women of reproductive age and maternal CHD ...

• Recurrent laryngeal nerve injury and nerve recovery evaluated by EMG, accelerometry and direct laryngoscopy : -An experimental approach - 

  Setså, Erling Johan (Doctoral thesis, 2024-12-13)

  Den mest fryktede komplikasjonen ved endokrinkirurgi på hals er bilateral skade på nervus laryngeus rekurrens (RLN) som kan føre til lammelse av stemmebåndene, ledsaget av alvorlige respirasjonsproblemer som kan ende i ...

• Lung function in Norway in the 20th century : Trends, lower limits of normality and overall and specific mortalities 

  Cestelli, Lucia (Doctoral thesis, 2024-12-06)

  Bakgrunn og mål: Lungefunksjon er en markør for generell helse og kan predikere mortalitet. Flere faktorer påvirker måling og tolkning av lungefunksjon i en befolkning. Målet med dette doktorgradsarbeidet var å studere den ...

• Preoperative risk factors associated with left ventricular dysfunction after bariatric surgery 

  Grymyr, Lisa Marie Dale; Mellgren, Gunnar; McCann, Adrian; Gerdts, Eva; Meyer, Klaus; Nadirpour, Saied; Fernø, Johan; Nedrebø, Bjørn Gunnar; Cramariuc, Dana (Journal article; Peer reviewed, 2024)

  A large proportion of patients with severe obesity remain with left ventricular (LV) dysfunction after bariatric surgery. We assessed whether preoperative evaluation by echocardiography and inflammatory proteins can identify ...

• Prognostic factors, treatment approach and clinical outcomes from glioblastoma: a population-based observational cohort study from Western Norway 

  Bjorland, Line Sagerup (Doctoral thesis, 2024-12-06)

  Bakgrunn: Glioblastom er den vanligste og mest aggressive primære hjernesvulst hos voksne, og prognosen er svært alvorlig med median overlevelse på omtrent 15 måneder tross standard behandling med radiokjemoterapi. I klinisk ...

• Left ventricular mechanics and oxygen demand in patients with severe obesity undergoing Roux-en-Y gastric bypass surgery 

  Grymyr, Lisa Marie Dale (Doctoral thesis, 2024-11-29)

  Bakgrunn og mål: Venstre ventrikkel (VV) er eksponert for kronisk trykk- og volumoverbelastning ved alvorlig fedme. Effekten av vektreduserende kirurgi på fedme-relatert VV-dysfunksjon har ikke vært kartlagt i detalj ...

• The NORwegian atrial fibrillation self-SCREENing (NORSCREEN) trial: rationale and design of a randomized controlled trial 

  Boskovic, Miroslav; Jortveit, Jarle; Haraldsen, Marius Blørstad; Berge, Trygve; Engdahl, Johan; Løchen, Maja-Lisa; Schuster, Peter Moritz; Sandberg, Edvard Liljedahl; Grimsmo, Jostein; Atar, Dan; Anfinsen, Ole-Gunnar; Pripp, Are Hugo; Grenne, Bjørnar Leangen; Halvorsen, Sigrun (Journal article; Peer reviewed, 2024)

  Aims Atrial fibrillation (AF) is a common arrhythmia, and many cases of AF may be undiagnosed. Whether screening for AF and subsequent treatment if AF is detected can improve long-term outcome remains an unsettled ...

• HyperTraPS-CT: Inference and prediction for accumulation pathways with flexible data and model structures 

  Aga, Olav Nicolay Larsson; Brun, Morten; Dauda, Kazeem Adesina; Diaz-Uriarte, Ramon; Giannakis, Konstantinos; Johnston, Iain (Journal article; Peer reviewed, 2024-09-04)

  Accumulation processes, where many potentially coupled features are acquired over time, occur throughout the sciences from evolutionary biology to disease progression, and particularly in the study of cancer progression. ...

• SARS-CoV-2 infection in healthcare workers, and biomarkers of long COVID 

  Bansal, Amit (Doctoral thesis, 2024-11-27)

  I denne doktorgradsavhandlingen har vi studert risikoen for å bli smittet av SARS-CoV-2 virus blant norske helsearbeidere gjennom de ulike covid-19 smittebølgene. Kunnskap om prevalens og risikofaktorer for smitte hos ...

• Prostate Biopsies Can Be Omitted in Most Patients with a Positive Stockholm3 Test and Negative Prostate Magnetic Resonance Imaging 

  Vinje, Cathrine Alvær; Vigmostad, Maria Nyre; Kjosavik, Svein Reidar; Grönberg, Henrik; Gilje, Bjørnar; Skeie, Svein (Journal article; Peer reviewed, 2024)

  Background Magnetic resonance imaging (MRI) combined with the Stockholm3 test can be used to inform biopsy decision-making in patients with a suspicion of prostate cancer. Objective To determine the consequence of ...

• Effect of Therapeutic Drug Monitoring on Adherence and Blood Pressure: A Multicenter Randomized Clinical Trial 

  Halvorsen, Lene Vernås; Søraas, Camilla Lund; Larstorp, Anne Cecilie Kjeldsen; Hjørnholm, Ulla; Kjær, Vibeke Norheim; Liestøl, Knut; Aune, Arleen; Olsen, Erik; Brobak, Karl Marius; Bergland, Ola Undrum; Rognstad, Stine; Aarskog, Nikolai Ravn; Heimark, Sondre; Fadl Elmula, Fadl Elmula M.; Gerdts, Eva; Mo, Rune; Solbu, Marit Dahl; Opdal, Mimi Stokke; Kjeldsen, Sverre; Rostrup, Morten; Høieggen, Aud (Journal article; Peer reviewed, 2024)

  Background: Drug concentration in blood or urine is an acknowledged method to detect nonadherence. Observational studies suggest that informing patients about low or absent serum drug levels improves blood pressure (BP). ...

• Efficient CAR T cell targeting of the CA125 extracellular repeat domain of MUC16 

  Casey, Nicholas Paul; Kleinmanns, Katrin; Forcados, Christopher; Gelebart, Pascal Francois; Joaquina, Sandy; Lode, Martine Rott; Benard, Emmanuelle; Kaveh, Fatemeh; Caulier, Benjamin William; Gjerde, Christiane Helgestad; García de Jalón, Elvira; Warren, David; Lindemann, Kristina Yvonne Kathe; Rokkones, Erik; Davidson, Ben; Myhre, Marit; Kvalheim, Gunnar; Bjørge, Line; Mc Cormack, Emmet; Inderberg, Else Marit; Wälchli, Sébastien (Journal article; Peer reviewed, 2024)

  Background Ovarian cancer (OC) is the leading cause of death from gynecologic malignancies in the Western world. Contributing factors include a high frequency of late-stage diagnosis, the development of chemoresistance, ...

• Characterisation of global and regional mitral annular strains in an acute porcine model 

  Persson, Robert Matongo; Aguilera, Hans Martin Dahl; Grong, Ketil; Kvitting, John-Peder Escobar; Stangeland, Lodve; Haaverstad, Rune; Urheim, Stig; Prot, Victorien Emile (Journal article, 2024)

  OBJECTIVES This study aimed to explore regional mitral annular strain using a novel computational method. METHODS Eight pigs underwent implantation with piezoelectric transducers around the mitral annulus. Interventions ...

• Association between dietary macronutrient composition and plasma one-carbon metabolites and B-vitamin cofactors in patients with stable angina pectoris 

  Bråtveit, Marianne; Parys, Anthea van; Olsen, Thomas; Strand, Elin; Marienborg, Ingvild; Laupsa-Borge, Johnny; Haugsgjerd, Teresa Risan; McCann, Adrian; Dhar, Indu; Ueland, Per Magne; Dierkes, Jutta; Dankel, Simon Erling Nitter; Nygård, Ottar Kjell; Lysne, Vegard (Journal article; Peer reviewed, 2024)

  Elevated plasma concentrations of several one-carbon metabolites are associated with increased CVD risk. Both diet-induced regulation and dietary content of one-carbon metabolites can influence circulating concentrations ...

• Extracellular matrix remodelling pathway in peripheral blood mononuclear cells from severe COVID-19 patients: an explorative study 

  Murphy, Sarah Louise Mikalsen; Balzer, Nora Reka; Ranheim, Trine; Sagen, Ellen Lund; Huse, Camilla; Bjerkeli, Vigdis; Michelsen, Annika Elisabet; Finbråten, Ane-Kristine; Heggelund, Lars; Dyrhol-Riise, Anne Ma; Tveita, Anders; Holten, Aleksander Rygh; Trøseid, Marius; Ueland, Thor; Ulas, Thomas; Aukrust, Pål; Barratt-Due, Andreas; Halvorsen, Bente; Dahl, Tuva Børresdatter (Journal article; Peer reviewed, 2024)

  There is a reciprocal relationship between extracellular matrix (ECM) remodelling and inflammation that could be operating in the progression of severe COVID-19. To explore the immune-driven ECM remodelling in COVID-19, ...

• Sex differences in left atrial volumes, mechanics, and stiffness in primary mitral regurgitation - a combined 2D and 3D echocardiographic study 

  Berg-Hansen, Christian Engelsen; Sindre, Rasmus Bach; Grymyr, Lisa Marie Dale; Rogge, Barbara; Valeur, Andreas Egeli; Urheim, Stig; Hung, Judy; Cramariuc, Dana (Journal article; Peer reviewed, 2024)

  Aims Mitral regurgitation (MR) causes left atrial (LA) enlargement and impaired reservoir function. We assessed whether changes in LA size, strain, and stiffness in significant (moderate or greater) primary MR are ...

• Protein and transcriptional biomarker profiling may inform treatment strategies in lower respiratory tract infections by indicating bacterial–viral differentiation 

  Sivakumaran, Dhanasekaran; Jenum, Synne; Markussen, Dagfinn Lunde; Serigstad, Sondre; Srivastava, Aashish; Saghaug, Christina Skår; Ulvestad, Elling; Knoop, Siri Tandberg; Grewal, Harleen (Journal article; Peer reviewed, 2024)

  Lower respiratory tract infections (LRTIs) remain a significant global cause of infectious disease-related mortality. Accurate discrimination between acute bacterial and viral LRTIs is crucial for optimal patient care, ...

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