• Insall proximal realignment with/without tibial tubercle osteotomy for recurrent patellar instability yields acceptable medium- to long-term results but risk of osteoarthritis progression is considerable 

  Waaler, Per Arne Skarstein; Jellestad, Truls; Hysing-Dahl, Trine; Elvehøy, Elise; Inderhaug, Eivind (Journal article; Peer reviewed, 2022-07-06)

  Purpose: The purpose of this study was to evaluate clinical and radiological results in patients operated for recurrent patellar instability with a surgical approach consisting of Insall proximal realignment with/without ...

• Toll-like Receptor 4, Osteoblasts and Leukemogenesis; the Lesson from Acute Myeloid Leukemia 

  Bruserud, Øystein; Reikvam, Håkon; Brenner, Annette (Journal article; Peer reviewed, 2022-01-23)

  Toll-like receptor 4 (TLR4) is a pattern-recognizing receptor that can bind exogenous and endogenous ligands. It is expressed by acute myeloid leukemia (AML) cells, several bone marrow stromal cells, and nonleukemic cells ...

• Perceptions of generic medicines and medication adherence after percutaneous coronary intervention: a prospective multicentre cohort study 

  Pettersen, Trond Røed; Schjøtt, Jan Didrik; Allore, Heather G; Bendz, Bjørn; Borregaard, Britt; Fridlund, Bengt Gotthard Anton; Larsen, Alf Inge; Nordrehaug, Jan Erik; Rotevatn, Svein; Wentzel-Larsen, Tore; Norekvål, Tone Merete (Journal article; Peer reviewed, 2022)

  Objective: To determine patient perceptions of generic medicines 2 and 6 months after percutaneous coronary intervention (PCI), and to determine whether these perceptions moderate medication adherence. Design: Prospective ...

• Cortical thickness changes after computerized working memory training in patients with mild cognitive impairment 

  Hol, Haakon Ramsland; Flak, Marianne Møretrø; Chang, Linda; Løhaugen, Gro; Bjuland, Knut Jørgen; Rimol, Lars Morten; Engvig, Andreas; Skranes, Jon Sverre; Ernst, Thomas; Madsen, Bengt-Ove; Hernes, Susanne M S (Journal article; Peer reviewed, 2022-04-04)

  Background: Adaptive computerized working memory (WM) training has shown favorable effects on cerebral cortical thickness as compared to non-adaptive training in healthy individuals. However, knowledge of WM training-related ...

• CA-125 levels are predictive of survival in low-grade serous ovarian cancer—A multicenter analysis 

  Wohlmuth, Christoph; Djedovic, Vladimir; Kjær, Susanne K.; Jensen, Allan; Glasspool, Rosalind; Roxburgh, Patricia; Defazio, Anna; Johnatty, Sharon E.; Webb, Penelope M.; Modugno, Francesmary; Lambrechts, Diether; Schildkraut, Joellen M.; Berchuck, Andrew; Thomsen, Liv Cecilie Vestrheim; Bjørge, Line; Høgdall, Estrid; Høgdall, Claus K.; Goode, Ellen L.; Winham, Stacey J.; Matsuo, Keitaro; Karlan, Beth Y.; Lester, Jenny; Goodman, Marc T.; Thompson, Pamela J.; Pejovic, Tanja; Riggan, Marjorie J.; Lajkosz, Katherine; Tone, Alicia; May, Taymaa (Journal article; Peer reviewed, 2022-04-13)

  Objective: Studies on low-grade serous ovarian cancer (LGSC) are limited by a low number of cases. The aim of this study was to define the prognostic significance of age, stage, and CA-125 levels on survival in a ...

• The Association between Serum Serine and Glycine and Related-Metabolites with Pancreatic Cancer in a Prospective Cohort Study 

  Luu, Hung N.; Paragomi, Pedram; Wang, Renwei; Huang, Joyce Y.; Adams-Haduch, Jennifer; Midttun, Øivind; Ulvik, Arve; Nguyen, Tin C.; Brand, Randall E.; Gao, Yutang; Ueland, Per Magne; Yuan, Jian-Min (Journal article; Peer reviewed, 2022-04-28)

  Background: Serine and glycine play an important role in the folate-dependent one-carbon metabolism. The metabolism of serine and glycine has been shown to be associated with cancer cell proliferation. No prior epidemiologic ...

• A Novel Prophylaxis Strategy Using Liposomal Vaccine Adjuvant CAF09b Protects against Influenza Virus Disease 

  Zimmermann, Julie; Schmidt, Signe Tandrup; Trebbien, Ramona; Cox, Rebecca Jane; Zhou, Fan; Follmann, Frank; Pedersen, Gabriel Kristian; Christensen, Dennis (Journal article; Peer reviewed, 2022-02-06)

  The SARS-CoV-2 pandemic caused a massive health and societal crisis, although the fast development of effective vaccines reduced some of the impact. To prepare for future respiratory virus pandemics, a pan-viral prophylaxis ...

• Mapping the expression of an ANK3 isoform associated with bipolar disorder in the human brain 

  Holmgren, Asbjørn; Hansson, Lars; Bjerkaas-Kjeldal, Kristine; Impellizzeri, Agata Antonia Rita; Gilfillan, Gregor; Djurovic, Srdjan; Hughes, Timothy (Journal article; Peer reviewed, 2022)

  The gene ankyrin-3 (ANK3) has been consistently associated with bipolar disorder (BD) in several genome-wide association studies (GWAS). The exact molecular mechanisms underlying this genetic association remain unknown. ...

• Put your weight behind it—Effect of body mass index on the active second stage of labour: A retrospective cohort study 

  Østborg, Tilde Broch; Sande, Ragnar; Kessler, Jørg; Tappert, Christian; Von, Brandis Philip; Eggebø, Torbjørn Moe (Journal article; Peer reviewed, 2022)

  Objective: To explore the duration of the active phase of the second stage of labour in relation to maternal pre-pregnant body mass index (BMI). Design: Retrospective cohort study. Setting: Labour wards of three ...

• Prenatal dexamethasone treatment for classic 21-hydroxylase deficiency in Europe 

  Nowotny, Hanna; Neumann, Uta; Tardy-Guidollet, Veronique; Faisal Ahmed, Ahmed; Baronio, Federico; Battelino, Tadej; Bertherat, Jerome; Blankenstein, Oliver; Bonomi, Marco; Bouvattier, Claire; De la Perrière, Aude Brac; Brucker, Sara; Cappa, Marco; Chanson, Philippe; Van der Grinten, Hedi L. Claahsen; Colao, Annamaria; Cools, Martine; Davies, Justin H.; Dorr, Helmut-Gunther; Fenske, Wiebke K.; Ghigo, Ezio; Giordano, Roberta; Gravholt, Claus H.; Huebner, Angela; Husebye, Eystein Sverre; Igbokwe, Rebecca; Juul, Anders; Kiefer, Florian W.; Leger, Juliane; Menassa, Rita; Meyer, Gesine; Neocleous, Vassos; Phylactou, Leonidas A.; Rohayem, Julia; Russo, Gianni; Scaroni, Carla; Touraine, Philippe; Unger, Nicole; Vojtkova, Jarmila; Yeste, Diego; Lajic, Svetlana; Reisch, Nicole (Journal article; Peer reviewed, 2022)

  Objective: To assess the current medical practice in Europe regarding prenatal dexamethasone (Pdex) treatment of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. Design and methods: A questionnaire ...

• Factors associated with coronary heart disease in COPD patients and controls 

  Svendsen, Christina D.; Kuiper, Karel Kier-Jan; Ostridge, Kristoffer; Larsen, Terje Hjalmar; Nielsen, Rune; Hodneland, Vidar; Nordeide, Eli; Bakke, Per S.; Eagan, Tomas Mikal Lind (Journal article; Peer reviewed, 2022-04-27)

  Background: COPD and coronary heart disease (CHD) frequently co-occur, yet which COPD phenotypes are most prone to CHD is poorly understood. The aim of this study was to see whether COPD patients did have a true higher ...

• Development of UHPLC-MS/MS methods to quantify 25 antihypertensive drugs in serum in a cohort of patients treated for hypertension 

  Thorstensen, Christian W.; Clasen, Per-Erik; Rognstad, Stine; Haldsrud, Renate; Føreid, Siri; Helstrøm, Trine; Bergland, Ola Undrum; Halvorsen, Lene Vernås; Aune, Arleen; Olsen, Erik; Brobak, Karl Marius; Høieggen, Aud; Gustavsen, Ingebjørg G.; Larstorp, Anne Cecilie Kjeldsen; Søraas, Camilla Lund; Opdal, Mimi Stokke (Journal article; Peer reviewed, 2022)

  We developed three ultra-high pressure liquid chromatography coupled to mass spectrometry detection (UHPLC-MS/MS) methods to quantify 25 antihypertensive drugs in serum samples. Patient-reported drug lists were collected, ...

• Even chained acylcarnitines predict long-term cardiovascular prognosis in patients with chest pain and non-obstructive coronary artery disease 

  Storesund, Silje Kjellevold; Karaji, Iman; Strand, Elin; Svardal, Asbjørn M.; Lønnebakken, Mai Tone; Berge, Rolf Kristian; Svingen, Gard Frodahl Tveitevåg; Nygård, Ottar Kjell; Pedersen, Eva Ringdal (Journal article; Peer reviewed, 2022)

  Background Acylcarnitines are essential for mitochondrial fatty acid oxidation. Earlier studies suggest that impaired energy metabolism may be implicated in the pathogenesis of microvascular angina. We explored metabolites ...

• No difference in serum levels of B-cell activating receptor and antibodies against cytolethal distending toxin B and flagellin in post-infectious irritable bowel syndrome and chronic fatigue syndrome after Giardia infection 

  Hanevik, Kurt; Saghaug, Christina Skår; Aaland, Maren; Mørch, Kristine; Langeland, Nina (Journal article; Peer reviewed, 2022)

  Background and Aim Functional gastrointestinal disorders (FGIDs) and chronic fatigue syndrome (CFS) frequently occur as comorbid conditions to each other. A shared etiology of these syndromes has been proposed because of ...

• Aberrant signaling of immune cells in Sjögren's syndrome patient subgroups upon interferon stimulation 

  Sarkar, Irene; Davies, Richard Allan; Aarebrot, Anders Krogh; Solberg, Silje Michelsen; Petrovic, Aleksandra; Joshi, Anagha; Bergum, Brith; Brun, Johan Gorgas; Hammenfors, Daniel; Jonsson, Roland; Appel, Silke (Journal article; Peer reviewed, 2022)

  Background: Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease, characterized by mononuclear cell infiltrates in the salivary and lacrimal glands, leading to glandular atrophy and dryness. Patient heterogeneity ...

• Shared genetic architecture between schizophrenia and subcortical brain volumes implicates early neurodevelopmental processes and brain development in childhood 

  Cheng, Weiqiu; van der Meer, Dennis; Parker, Nadine; Hindley, Guy Frederick Lanyon; O'Connell, Kevin Sean; Wang, Yunpeng; Shadrin, Alexey; Alnæs, Dag; Bahrami, Shahram; Lin, Aihua; Karadag, Naz; Holen, Børge; Fernández-Cabello, Sara; Fan, Chun-Chieh; Dale, Anders; Djurovic, Srdjan; Westlye, Lars Tjelta; Frei, Oleksandr; Smeland, Olav Bjerkehagen; Andreassen, Ole (Journal article; Peer reviewed, 2022)

  Patients with schizophrenia have consistently shown brain volumetric abnormalities, implicating both etiological and pathological processes. However, the genetic relationship between schizophrenia and brain volumetric ...

• Randomized implementation of a primary human papillomavirus testing-based cervical cancer screening protocol for women 34 to 69 years in Norway 

  Nygård, Mari; Engesæter, Birgit Øvstebø; Castle, Philip E.; Berland, Jannicke; Eide, Maj Liv; Iversen, Ole-Erik; Jonassen, Christine M; Christiansen, Irene Kraus; Vintermyr, Olav Karsten; Trope, Ameli (Journal article; Peer reviewed, 2022)

  Background: Cervical cancer screening programs are facing a programmatic shift where screening protocol based on human papillomavirus testing (HPV-Screening protocol) is replacing the liquid-based cytology (LBC-Screening ...

• Eksamensformer i de norske medisinstudiene 

  Raaheim, Ole Farestvedt; Raaheim, Dag Farestvedt; Reikvam, Håkon; Kvernenes, Monika (Journal article; Peer reviewed, 2022)

  BAKGRUNN Det finnes ingen samlet oversikt over hvilke eksamensformer som er i bruk i de norske medisinstudiene. I denne studien har vi kartlagt hvilke eksamensformer som er i bruk, og analysert studieledelsenes begrunnelser ...

• Multimarker profiling identifies protective and harmful immune processes in heart failure: Findings from BIOSTAT-CHF 

  Markousis-Mavrogenis, George; Tromp, Jasper; Ouwerkerk, Wouter; Ferreira, João Pedro; Anker, Stefan D; Cleland, John G; Dickstein, Kenneth; Filippatos, Gerasimos; Lang, Chim C; Metra, Marco; Samani, Nilesh J; De Boer, Rudolf A; Van Veldhuisen, Dirk J; Voors, Adriaan A; Van Der Meer, Peter (Journal article; Peer reviewed, 2022)

  Aims The exploration of novel immunomodulatory interventions to improve outcome in heart failure (HF) is hampered by the complexity/redundancies of inflammatory pathways, which remain poorly understood. We thus aimed to ...

• Thrombectomy in large vessel occlusion stroke—Does age matter? 

  Rezai Kallaj, Mehdi; Dalen, Ingvild; Advani, Rajiv; Fjetland, Lars; Kurz, Kathinka Dæhli; Sandve, Knut Olav Lende; Kurz, Friedrich Martin Wilhelm (Journal article; Peer reviewed, 2022)

  Objectives Endovascular treatment (EVT) is the gold standard treatment for emergent large vessel occlusion (LVO). The benefit of EVT for emergent LVO in elderly patients (>80 years old) is still debated as they have been ...

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