• Cold-stored whole blood in a Norwegian emergency helicopter service: an observational study on storage conditions and product quality 

  Bjerkvig, Christopher Kalhagen; Sivertsen, Joar; Bråthen, Hanne Kristin; Lunde, Turid Helen Felli; Strandenes, Geir; Assmus, Jörg; Hervig, Tor; Cap, Andrew P.; Kristoffersen, Einar Klæboe; Fosse, Theodor; Apelseth, Torunn Oveland (Journal article; Peer reviewed, 2020)

  BACKGROUND Increasing numbers of emergency medical service agencies and hospitals are developing the capability to administer blood products to patients with hemorrhagic shock. Cold‐stored whole blood (WB) is the only ...

• The progression of acute myeloid leukemia from first diagnosis to chemoresistant relapse: A comparison of proteomic and phosphoproteomic profiles 

  Aasebø, Elise; Berven, Frode; Hovland, Randi; Doskeland, Stein Ove; Bruserud, Øystein; Selheim, Frode; Hernandez-Valladares, Maria (Journal article; Peer reviewed, 2020)

  Acute myeloid leukemia (AML) is an aggressive hematological malignancy. Nearly 50% of the patients who receive the most intensive treatment develop chemoresistant leukemia relapse. Although the leukemogenic events leading ...

• The implementation of mass spectrometry-based proteomics workflows in clinical routines of acute myeloid leukemia: Applicability and perspectives 

  Hernandez-Valladares, Maria; Bruserud, Øystein; Selheim, Frode (Journal article; Peer reviewed, 2020)

  With the current reproducibility of proteome preparation workflows along with the speed and sensitivity of the mass spectrometers, the transition of the mass spectrometry (MS)-based proteomics technology from biomarker ...

• The emerging role of cd24 in cancer theranostics—a novel target for fluorescence image-guided surgery in ovarian cancer and beyond 

  Kleinmanns, Katrin; Fosse, Vibeke Samuelsen; Bjørge, Line; McCormack, Emmet (Journal article; Peer reviewed, 2020)

  Complete cytoreductive surgery is the cornerstone of the treatment of epithelial ovarian cancer (EOC). The application of fluorescence image-guided surgery (FIGS) allows for the increased intraoperative visualization and ...

• Febrile Neutropenia in Acute Leukemia. Epidemiology, Etiology, Pathophysiology and Treatment 

  Hansen, Bent Are; Wendelbo, Øystein; Bruserud, Øyvind; Hemsing, Anette Lodvir; Mosevoll, Knut Anders; Reikvam, Håkon (Journal article; Peer reviewed, 2020)

  Acute leukemias are a group of aggressive malignant diseases associated with a high degree of morbidity and mortality. An important cause of both the latter is infectious complications. Patients with acute leukemia are ...

• TLR3 expression by maternal and fetal cells at the maternal-fetal interface in normal and preeclamptic pregnancies 

  Gierman, Lobke; Silva, Gabriela; Pervaiz, Zahra; Rakner, Johanne Johnsen; Mundal, Siv Boon; Thaning, Astrid J.; Nervik, Ingunn; Elschot, Mattijs; Mathew, Seema; Thomsen, Liv Cecilie Vestrheim; Bjørge, Line; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2020)

  Inflammation and oxidative stress at the maternal‐fetal interface characterize the placental dysfunction that underlies the pregnancy disorder preeclampsia. Specialized fetal trophoblasts directly interact with leukocytes ...

• Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal 

  Svensson, Mattias N.D.; Zoccheddu, Martina; Yang, Shen; Nygaard, Gyrid; Secchi, Christian; Doody, Karen M.; Slowikowski, Kamil; Mizoguchi, Fumitaka; Humby, Frances; Hands, Rebecca; Santelli, Eugenio; Sacchetti, Cristiano; Wakabayashi, Kuninobu; Wu, Dennis J.; Barback, Christopher; Ai, Rizi; Wang, Wei; Sims, Gary P.; Mydel, Piotr Mateusz; Kasama, Tsuyoshi; Boyle, David L.; Galimi, Francesco; Vera, David; Tremblay, Michel L.; Raychaudhuri, Soumya; Brenner, Michael B.; Firestein, Gary S.; Pitzalis, Costantino; Ekwall, Anna-Karin H.; Stanford, Stephanie M.; Bottini, Nunzio (Journal article; Peer reviewed, 2020)

  Fibroblast-like synoviocytes (FLS) are joint-lining cells that promote rheumatoid arthritis (RA) pathology. Current disease-modifying antirheumatic agents (DMARDs) operate through systemic immunosuppression. FLS-targeted ...

• Tyrosine kinase inhibitors and interferon‐α increase tunneling nanotube (TNT) formation and cell adhesion in chronic myeloid leukemia (CML) cell lines ( 

  Omsland, Maria; Andresen, Vibeke; Gullaksen, Stein-Erik; Ayuda-Duran, Maria del Pilar; Popa, Mihaela Lucia; Hovland, Randi; Brendehaug, Atle; Enserink, Jorrit; Mc Cormack, Emmet; Gjertsen, Bjørn Tore (Journal article; Peer reviewed, 2020)

  Chronic myeloid leukemia (CML) is a stem cell disease of the bone marrow where mechanisms of inter‐leukemic communication and cell‐to‐cell interactions are proposed to be important for optimal therapy response. Tunneling ...

• SARS-CoV-2–Specific Neutralizing Antibody Responses in Norwegian Health Care Workers After the First Wave of COVID-19 Pandemic: A Prospective Cohort Study 

  Trieu, Mai Chi; Bansal, Amit; Madsen, Anders; Zhou, Fan; Sævik, Marianne; Vahokoski, Juha; Brokstad, Karl Albert; Krammer, Florian; Tøndel, Camilla; Mohn, Kristin Greve Isdahl; Blomberg, Bjørn; Langeland, Nina; Cox, Rebecca Jane (Journal article; Peer reviewed, 2021)

  Background During the coronavirus disease 2019 (COVID-19) pandemic, many countries experienced infection in health care workers (HCW) due to overburdened health care systems. Whether infected HCW acquire protective immunity ...

• Early Gut Fungal and Bacterial Microbiota and Childhood Growth 

  Schei, Kasper; Simpson, Melanie Rae; Avershina, Ekaterina; Rudi, Knut; Øien, Torbjørn; Juliusson, Petur Benedikt; Underhill, David; Salamati, Saideh; Ødegård, Rønnaug (Journal article; Peer reviewed, 2020)

  Introduction: Childhood growth is a sensitive marker of health. Animal studies show increased height and weight velocity in the presence of fungal as well as antibiotic supplement in feed. Human studies on early gut ...

• Residual Corticosteroid Production in Autoimmune Addison Disease 

  Sævik, Åse Bjorvatn; Åkerman, Anna-Karin; Methlie, Paal; Quinkler, Marcus; Jørgensen, Anders Palmstrøm; Høybye, Charlotte; Debowska, Aleksandra; Nedrebø, Bjørn Gunnar; Dahle, Anne Lise; Carlsen, Siri; Tomkowicz, Aneta; Sollid, Stina Therese; Nermoen, Ingrid; Grønning, Kaja; Dahlqvist, Per; Grimnes, Guri; Skov, Jakob; Finnes, Trine Elisabeth; Valland, Susanna Fonneland; Wahlberg, Jeanette; Holte, Synnøve Emblem; Simunkova, Katerina; Kämpe, Olle; Husebye, Eystein Sverre; Bensing, Sophie; Øksnes, Marianne (Journal article; Peer reviewed, 2020)

  Design: Two-staged, cross-sectional clinical study in 17 centers (Norway, Sweden, and Germany). Residual glucocorticoid (GC) production was defined as quantifiable serum cortisol and 11-deoxycortisol and residual ...

• Human mucosal IgA immune responses against enterotoxigenic escherichia coli 

  Riaz, Saman; Steinsland, Hans; Hanevik, Kurt (Journal article; Peer reviewed, 2020-08-29)

  Infection with enterotoxigenic Escherichia coli (ETEC) is a major contributor to diarrheal illness in children in low- and middle-income countries and travelers to these areas. There is an ongoing effort to develop vaccines ...

• Bioinformatic analyses of miRNA-mRNA signature during hiPSC differentiation towards insulin-producing cells upon HNF4α mutation 

  Ghila, Luiza; Bjørlykke, Yngvild; Legøy, Thomas Aga; Vethe, Heidrun; Furuyama, Kenichiro; Chera, Simona; Ræder, Helge (Journal article; Peer reviewed, 2020)

  Mutations in the hepatocyte nuclear factor 4α (HNF4α) gene affect prenatal and postnatal pancreas development, being characterized by insulin-producing β-cell dysfunction. Little is known about the cellular and molecular ...

• The core clock transcription factor BMAL1 drives circadian β-cell proliferation during compensatory regeneration of the endocrine pancreas 

  Petrenko, Volodymyr; Stolovich-Rain, Miri; Vandereycken, Bart; Giovannoni, Laurianne; Storch, Kai-Florian; Dor, Yuval; Chera, Simona; Dibner, Charna (Journal article; Peer reviewed, 2020)

  Circadian clocks in pancreatic islets participate in the regulation of glucose homeostasis. Here we examined the role of these timekeepers in β-cell regeneration after the massive ablation of β cells by doxycycline-induced ...

• Effects of a multicomponent high intensity exercise program on physical function and health-related quality of life in older adults with or at risk of mobility disability after discharge from hospital: a randomised controlled trial 

  Sunde, Sylvia; Hesseberg, Karin; Skelton, Dawn A.; Ranhoff, Anette Hylen; Pripp, Are Hugo; Aarønæs, Marit; Brovold, Therese (Journal article; Peer reviewed, 2020)

  Background Many older people suffer from mobility limitations and reduced health-related quality of life (HRQOL) after discharge from hospital. A consensus regarding the most effective exercise-program to optimize physical ...

• Endoplasmic Reticulum Calcium Pumps and Tumor Cell Differentiation 

  Papp, Bela; Launay, Sophie; Gelebart, Pascal; Arbabian, Atousa; Enyedi, Agnes; Brouland, Jean-Philippe; Carosella, Edgardo D.; Adle-Biassette, Homa (Journal article; Peer reviewed, 2020)

  Endoplasmic reticulum (ER) calcium homeostasis plays an essential role in cellular calcium signaling, intra-ER protein chaperoning and maturation, as well as in the interaction of the ER with other organelles. Calcium is ...

• The novel microRNAs hsa-miR-nov7 and hsamiR- nov3 are over-expressed in locally advanced breast cancer 

  Poduval, Deepak; Sichmanovà, Zuzana; Straume, Anne Hege; Lønning, Per Eystein; Knappskog, Stian (Journal article; Peer reviewed, 2020)

  miRNAs are an important class of small non-coding RNAs, which play a versatile role in gene regulation at the post-transcriptional level. Expression of miRNAs is often deregulated in human cancers. We analyzed small RNA ...

• Association of adult lung function with accelerated biological aging 

  Rezwan, Faizal I; Imboden, Medea; Amaral, André F.S.; Wielscher, Matthias; Jeong, Ayoung; Triebner, Kai; Gomez Real, Francisco; Jarvelin, Marjo-Riitta; Jarvis, Deborah; Probst-Hensch, Nicole M; Holloway, John W (Journal article; Peer reviewed, 2020)

  Lung function, strongly associated with morbidity and mortality, decreases with age. This study examines whether poor adult lung function is associated with age accelerations (AAs). DNA methylation (DNAm) based AAs, lifespan ...

• References for ultrasound staging of breast maturation, tanner breast staging, pubic hair, and menarche in Norwegian girls 

  Bruserud, Ingvild Særvold; Roelants, Mathieu; Oehme, Ninnie; Madsen, Andre; Eide, Geir Egil; Bjerknes, Robert; Rosendahl, Karen; Juliusson, Petur Benedikt (Journal article; Peer reviewed, 2020)

  Context: Discriminating adipose and glandular tissue is challenging when clinically assessing breast development. Ultrasound facilitates staging of pubertal breast maturation (US B), but has not been systematically compared ...

• Gene Methylation and Silencing of WIF1 Is a Frequent Genetic Abnormality in Mantle Cell Lymphoma 

  Alshareef, Abdulraheem; Gelebart, Pascal; Peters, Anthea C.; Chen, Will; Lai, Raymond (Journal article; Peer reviewed, 2021)

  We have previously shown that the Wnt canonical pathway (WCP) is constitutively active in most cases of mantle cell lymphoma (MCL). Here, we aimed to elucidate the mechanisms underlying this biochemical deregulation. We ...

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