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  • Shared Genetic Loci Between Schizophrenia and White Blood Cell Counts Suggest Genetically Determined Systemic Immune Abnormalities 

    Steen, Nils Eiel; Rahman, Zillur; Szabo, Attila; Hindley, Guy; Parker, Nadine; Cheng, Weiqiu; Lin, Aihua; O'Connell, Kevin S; Sheikh, Mashhood Ahmed; Shadrin, Alexey; Bahrami, Shahram; Karthikeyan, Sandeep; Hoseth, Eva Zsuzsanna; Dale, Anders M; Aukrust, Pål; Smeland, Olav Bjerkehagen; Ueland, Thor; Frei, Oleksandr; Djurovic, Srdjan; Andreassen, Ole (Journal article; Peer reviewed, 2023)
    Background: Immune mechanisms are indicated in schizophrenia (SCZ). Recent genome-wide association studies (GWAS) have identified genetic variants associated with SCZ and immune-related phenotypes. Here, we use cutting ...
  • The relationship between workload and exercise-induced cardiac troponin elevations is influenced by non-obstructive coronary atherosclerosis 

    Bjørkavoll-Bergseth, Magnus; Erevik, Christine Bjørkvik; Kleiven, Øyunn; Wiktorski, Tomasz; Auestad, Bjørn Henrik; Skadberg, Øyvind; Aakre, Kristin Moberg; Eijsvogels, Thijs M. H.; Ørn, Stein (Journal article; Peer reviewed, 2024)
    The relationship between exercise-induced troponin elevation and non-obstructive coronary artery disease (CAD) is unclear. This observational study assessed non-obstructive CAD's impact on exercise-induced cardiac Troponin ...
  • The first vanE-type vancomycin resistant Enterococcus faecalis isolates in Norway – phenotypic and molecular characteristics 

    al Rubaye, Mushtaq Talib Shawi; Janice, Jessin; Bjørnholt, Jørgen; Löhr, Iren Høyland; Sundsfjord, Arnfinn Ståle; Hegstad, Kristin (Journal article; Peer reviewed, 2023)
    Objectives We aimed to characterize the vanE cluster and its genetic support in the first Norwegian vanE-type isolates and assess genetic relatedness to other vanE isolates. Methods Two vanE-type vancomycin resistant ...
  • The relationship between exercise-induced cardiac Troponin increase and physical workload during prolonged strenuous exercise : North Sea Endurance Exercise Study (NEEDED) 2018 

    Bjørkavoll-Bergseth, Magnus (Doctoral thesis, 2024-06-06)
    Bakgrunn Høye nivåer av kardial troponin (cTn) er knyttet til økt dødelighet og en høyere sjanse for udiagnostisert koronararteriesykdom (CAD). Denne avhandlingen hadde som mål å undersøke sammenhengen mellom treningsintensitet ...
  • Extending protein interaction networks using proteoforms and small molecules 

    Sanchez, Luis Francisco Hernandez; Burger, Bram; Campos, Rodrigo Alexander Castro; Johansson, Stefan; Njølstad, Pål Rasmus; Barsnes, Harald; Vaudel, Marc (Journal article; Peer reviewed, 2023)
    Motivation: Biological network analysis for high-throughput biomedical data interpretation relies heavily on topological characteristics. Networks are commonly composed of nodes representing genes or proteins that are ...
  • Variation in antibiotic consumption in very preterm infants-a 10 year population-based study 

    Huncikova, Zuzana; Stensvold, Hans Jørgen; Øymar, Knut Asbjørn Alexander; Vatne, Anlaug; Lang, Astri Maria; Støen, Ragnhild; Brigtsen, Anne Karin; Moster, Dag; Eriksen, Beate Horsberg; Selberg, Terje Reidar; Rønnestad, Arild Erland; Klingenberg, Claus (Journal article; Peer reviewed, 2023)
    Objectives Wide variations in antibiotic use in very preterm infants have been reported across centres despite similar rates of infection. We describe 10 year trends in use of antibiotics and regional variations among ...
  • Machine learning approaches in microbiome research: challenges and best practices 

    Papoutsoglou, Georgios; Tarazona, Sonia; Lopes, Marta B.; Klammsteiner, Thomas; Ibrahimi, Eliana; Eckenberger, Julia; Novielli, Pierfrancesco; Tonda, Alberto; Simeon, Andrea; Shigdel, Rajesh; Béreux, Stéphane; Vitali, Giacomo; Tangaro, Sabina; Lahti, Leo; Temko, Andriy; Claesson, Marcus J.; Berland, Magali (Journal article; Peer reviewed, 2023)
    Microbiome data predictive analysis within a machine learning (ML) workflow presents numerous domain-specific challenges involving preprocessing, feature selection, predictive modeling, performance estimation, model ...
  • Phase II study of everolimus and temozolomide as first-line treatment in metastatic high-grade gastroenteropancreatic neuroendocrine neoplasms 

    Morken, Siren; Langer, Seppo W.; Sundlöv, Anna; Vestermark, Lene Weber; Ladekarl, Morten; Hjortland, Geir Olav; Svensson, Johanna B.; Tabaksblat, Elizaveta Mitkina; Haslerud, Torjan Magne; Assmus, Jörg; Detlefsen, Sönke; Couvelard, Anne; Perren, Aurel; Sorbye, Halfdan (Journal article; Peer reviewed, 2023)
    Background The optimal treatment for metastatic high-grade gastroenteropancreatic (GEP) neuroendocrine neoplasms when Ki-67 ≤55% is unknown. A prospective multi-centre phase 2 study was performed to evaluate the efficacy ...
  • Prolonging the delivery of influenza virus vaccine improves the quantity and quality of the induced immune responses in mice 

    Beukema, Martin; Gong, Shuran; Al-Jaawni, Kasem; de Vries-Idema, Jacqueline J.; Krammer, Florian; Zhou, Fan; Cox, Rebecca Jane; Huckriede, Anke (Journal article; Peer reviewed, 2023)
    Introduction: Influenza vaccines play a vital role in protecting individuals from influenza virus infection and severe illness. However, current influenza vaccines have suboptimal efficacy, which is further reduced in cases ...
  • Impaired glucose tolerance and cardiovascular risk factors in relation to infertility: a Mendelian randomization analysis in the Norwegian Mother, Father, and Child Cohort Study 

    Hernáez, Álvaro; Lee, Yunsung; Page, Christian Magnus; Skåra, Karoline Hansen; Håberg, Siri Eldevik; Magnus, Per Minor; Njølstad, Pål Rasmus; Andreassen, Ole; Corfield, Elizabeth Claire; Havdahl, Alexandra; Fraser, Abigail; Burgess, Stephen; Lawlor, Deborah A.; Magnus, Maria Christine (Journal article; Peer reviewed, 2024)
    Study question: Are impaired glucose tolerance (as measured by fasting glucose, glycated hemoglobin, and fasting insulin) and cardiovascular disease risk (as measured by low-density lipoprotein cholesterol, high-density ...
  • Distinct HLA associations with autoantibody-defined subgroups in idiopathic inflammatory myopathies 

    Leclair, Valérie; Galindo-Feria, Angeles S.; Rothwell, Simon; Kryštůfková, Olga; Zargar, Sepehr Sarrafzadeh; Mann, Herman; Diederichsen, Louise Pyndt; Andersson, Anna Helena; Klein, Martin; Tansley, Sarah; Rönnblom, Lars; Lindblad-Toh, Kerstin; Syvänen, Ann-Christine; Wahren Herlenius, Marie Elisabeth; Sandling, Johanna K.; Bianchi, Matteo; Lundberg, Ingrid E.; Padyukov, Leonid; Molberg, Øyvind; Lamb, Janine A.; Chinoy, Hector; Holmqvist, Marie; Diaz-Gallo, Lina-Marcela (Journal article; Peer reviewed, 2023)
    Background In patients with idiopathic inflammatory myopathies (IIM), autoantibodies are associated with specific clinical phenotypes suggesting a pathogenic role of adaptive immunity. We explored if autoantibody profiles ...
  • Is the fetus fit for labor? Introducing fast-and-frugal trees (FFTrees) to simplify triage of women for STAN monitoring: An interobserver agreement comparison with traditional classification 

    Pereira, Susana; Bakker, Petra; Zaima, Ahmed; Ghi, Tullio; Kessler, Jørg; Timonen, Susanna; Vayssière, Christoph; Löser, Katrin; Holmberg, Kaisa; Jacquemyn, Yves; Chandraharan, Edwin; Wertheim, David; Olofsson, Per (Journal article; Peer reviewed, 2023)
    Introduction It is a shortcoming of traditional cardiotocography (CTG) classification table formats that CTG traces are frequently classified differently by different users, resulting in poor interobserver agreements. ...
  • Altered biomarkers for cardiovascular disease and inflammation in autoimmune Addison's disease - a cross-sectional study 

    Sævik, Åse Bjorvatn; Ueland, Grethe Åstrøm; Åkerman, Anna-Karin; Methlie, Paal; Quinkler, Marcus; Jørgensen, Anders Palmstrøm; Höybye, Charlotte; Debowska, Aleksandra; Nedrebø, Bjørn Gunnar; Dahle, Anne Lise; Carlsen, Siri; Tomkowicz, Aneta; Sollid, Stina Therese; Nermoen, Ingrid; Grønning, Kaja; Dahlqvist, Per; Grimnes, Guri; Skov, Jakob; Finnes, Trine Elisabeth; Valland, Susanna Fonneland; Wahlberg, Jeanette; Holte, Synnøve Emblem; Kämpe, Olle; Bensing, Sophie; Husebye, Eystein Sverre; Øksnes, Marianne (Journal article; Peer reviewed, 2023)
    Objective: Increased prevalence of cardiovascular disease has been reported in autoimmune Addison's disease (AAD), but pathomechanisms are poorly understood. Design: Cross-sectional study. Methods: We compared serum ...
  • Do differences in diagnostic criteria for late fetal growth restriction matter? 

    Mylrea-Foley, Bronacha; Napolitano, Raffaele; Gordijn, Sanne; Wolf, Hans; Lees, Christoph C.; Stampalija, Tamara; Arabin, B.; Berger, A.; Bergman, E.; Bhide, A; Bilardo, C.M.; Breeze, A.C.; Brodszki, J.; Calda, P.; Cesari, E.; Cetin, I.; Derks, J.; Ebbing, Cathrine; Ferrazzi, E.; Frusca, T.; Ganzevoort, W.; Gyselaers, W.; Hecher, K.; Klaritsch, P.; Krofta, L.; Lindgren, P.; Lobmaier, S.M.; Marlow, N.; Maruotti, G.M.; Mecacci, F.; Myklestad, Kirsti; Prefumo, F.; Raio, L.; Richter, J.; Sande, Ragnar; Valensise, H.; Visser, G.H.A.; Wee, L. (Journal article; Peer reviewed, 2023)
    BACKGROUND Criteria for diagnosis of fetal growth restriction differ widely according to national and international guidelines, and further heterogeneity arises from the use of different biometric and Doppler reference ...
  • Reduced lung function and cause-specific mortality: A population-based study of Norwegian men followed for 26 years 

    Cestelli, Lucia; Gulsvik, Amund; Johannessen, Ane; Stavem, Knut; Nielsen, Rune (Journal article; Peer reviewed, 2023)
    Background and aim Reduced lung function is associated with increased mortality, but it is unclear how different spirometric patterns are related to specific deaths. Aim of this study was to investigate these associations ...
  • Low levels of endogenous anabolic androgenic steroids in females with severe asthma taking corticosteroids 

    Yasinska, Valentyna; Gómez, Cristina; Kolmert, Johan; Ericsson, Magnus; Pohanka, Anton; James, Anna; Andersson, Lars I.; Sparreman-Mikus, Maria; Sousa, Ana R.; Riley, John H.; Bates, Stewart; Bakke, Per S.; Kermani, Nazanin Zounemat; Caruso, Massimo; Chanez, Pascal; Fowler, Stephen J.; Geiser, Thomas; Howarth, Peter H.; Horváth, Ildikó; Krug, Norbert; Montuschi, Paolo; Sanak, Marek; Behndig, Annelie; Shaw, Dominick E.; Knowles, Richard G.; Dahlén, Barbro; van der Zee, Anke-Hilse Maitland; Sterk, Peter J.; Djukanovic, Ratko; Adcock, Ian M.; Chung, Kian Fan; Wheelock, Craig E.; Dahlén, Sven-Erik; Jonsson, Eva Wikström (Journal article; Peer reviewed, 2023)
    Rationale Patients with severe asthma are dependent upon treatment with high doses of inhaled corticosteroids (ICS) and often also oral corticosteroids (OCS). The extent of endogenous androgenic anabolic steroid (EAAS) ...
  • Relation between HLA and copy number variation of steroid 21-hydroxylase in a Swedish cohort of patients with autoimmune Addison’s disease 

    Lundtoft, Christian; Eriksson, Daniel; Bianchi, Matteo; Aranda-Guillén, Maribel; Landegren, Nils; Rantapää-Dahlqvist, Solbritt; Söderkvist, Peter; Meadows, Jennifer R.S.; Bensing, Sophie; Pielberg, Gerli Rosengren; Lindblad-Toh, Kerstin; Rönnblom, Lars; Kämpe, Olle (Journal article; Peer reviewed, 2023)
    Objective Autoantibodies against the adrenal enzyme 21-hydroxylase is a hallmark manifestation in autoimmune Addison's disease (AAD). Steroid 21-hydroxylase is encoded by CYP21A2, which is located in the human leucocyte ...
  • Aiming toWards Evidence baSed inTerpretation of Cardiac biOmarkers in patients pResenting with chest pain using Point of Care Testing (WESTCOR-POC): study design 

    Thulin, Ingrid Viola Lavesson; Jordalen, Silje Marie Farestveit; Lekven, Ole Christian; Krishnapillai, Jeyaseelan; Steiro, Ole-Thomas; Collinson, Paul; Apple, Fred; Cullen, Louise; Norekvål, Tone Merete; Wisløff, Torbjørn; Vikenes, Kjell; Omland, Torbjørn; Bjørneklett, Rune Oskar; Aakre, Kristin Moberg (Journal article; Peer reviewed, 2023)
    Objectives: Patients presenting with symptoms suggestive of acute coronary syndrome (ACS) contribute to a high workload and overcrowding in the Emergency Department (ED). Accelerated diagnostic protocols for non-ST-elevation ...
  • The diagnostic utility of microscopic quality assessment of sputum samples in the era of rapid syndromic PCR testing 

    Markussen, Dagfinn Lunde; Ebbesen, Marit Helen; Serigstad, Sondre; Knoop, Siri Tandberg; Ritz, Christian; Bjørneklett, Rune Oskar; Kommedal, Øyvind; Jenum, Synne; Ulvestad, Elling; Grewal, Harleen (Journal article; Peer reviewed, 2023)
    This prospective study assessed the value of initial microscopy evaluation of sputum samples submitted for rapid syndromic PCR-based testing. Bacterial detections by the BioFire FilmArray Pneumonia Panel plus in 126 high- ...
  • Human Embryonic Development : Effects of Physical Activity and Sleep in Physiological Pregnancies 

    Vietheer, Alexander (Doctoral thesis, 2024-05-03)
    Bakgrunn: Forskningsfeltet "Developmental Origin of Health and Disease" (DOHaD) har vist hvor betydningsfull fosterutviklingen er for individets fremtidige helse og sykdomsrisiko. I senere år har den tidligste perioden av ...

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