• β-blocker use and risk of all-cause mortality in patients with coronary heart disease: effect modification by serum vitamin A 

  Dhar, Indu; Svingen, Gard Frodahl Tveitevåg; Olsen, Thomas; Lysne, Vegard; Bjørnestad, Espen Øglænd; Ueland, Per Magne; Nygård, Ottar Kjell (Journal article; Peer reviewed, 2021)

  Aims  Blockade of β-adrenoceptors reduces sympathetic nervous system activity and improves survival in patients with heart failure with reduced left ventricular ejection fraction (HFrEF); however, any improvement in ...

• Describing the status of reproductive ageing simply and precisely: A reproductive ageing score based on three questions and validated with hormone levels 

  Triebner, Kai; Johannessen, Ane; Svanes, Cecilie; Leynaert, Bénédicte; Benediktsdóttir, Bryndís; Demoly, Pascal; Dharmage, Shyamali C.; Franklin, Karl A.; Heinrich, Joachim; Holm, Mathias; Jarvis, Deborah; Lindberg, Eva; Moratalla, Jesús Martínez; Agirre, Nerea Muniozguren; Sánchez-Ramos, José Luis; Schlünssen, Vivi; Skulstad, Svein Magne; Hustad, Steinar; Rodríguez, Francisco J.; Gomez Real, Francisco (Journal article; Peer reviewed, 2020)

  Objective Most women live to experience menopause and will spend 4–8 years transitioning from fertile age to full menstrual stop. Biologically, reproductive ageing is a continuous process, but by convention, it is defined ...

• The extracellular bone marrow microenvironment — a proteomic comparison of constitutive protein release by in vitro cultured osteoblasts and mesenchymal stem cells 

  Aasebø, Elise; Birkeland, Even; Selheim, Frode; Berven, Frode; Brenner, Annette; Bruserud, Øystein (Journal article; Peer reviewed, 2021)

  Mesenchymal stem cells (MSCs) and osteoblasts are bone marrow stromal cells that contribute to the formation of stem cell niches and support normal hematopoiesis, leukemogenesis and development of metastases from distant ...

• Return to work after coronary artery bypass grafting and aortic valve replacement surgery: A scoping review 

  Mortensen, Michael André Helnes; Sandvik, Reidun Karin Norheim Myhre; Svendsen, Øyvind Sverre; Haaverstad, Rune; Moi, Asgjerd Litlere (Journal article; Peer reviewed, 2021)

  Background Coronary artery bypass grafting surgery and aortic valve replacement surgery are essential treatment options for people suffering from angina pectoris or aortic valve disease. Surgery aims to prolong life ...

• Genome-wide Association Analysis of Parkinson’s Disease and Schizophrenia Reveals Shared Genetic Architecture and Identifies Novel Risk Loci 

  Smeland, Olav Bjerkehagen; Shadrin, Alexey A.; Bahrami, Shahram; Broce, Iris J.; Tesli, Martin Steen; Frei, Oleksandr; Wirgenes, Katrine Verena; O`Connell, Kevin; Krull, Florian; Bettella, Francesco; Steen, Nils Eiel; Sugrue, Leo P.; Wang, Yunpeng; Svenningsson, Per; Sharma, Manu; Pihlstrøm, Lasse; Toft, H. Mathias S.; O’Donovan, Michael; Djurovic, Srdjan; Desikan, Rahul S; Dale, Anders M.; Andreassen, Ole Andreas (Journal article; Peer reviewed, 2021)

  Background Parkinson’s disease (PD) and schizophrenia (SCZ) are heritable brain disorders that involve dysregulation of the dopaminergic system. Epidemiological studies have reported potential comorbidity between the ...

• NordAqua, a Nordic Center of Excellence to develop an algae-based photosynthetic production platform 

  Allahverdiyeva, Yagut; Aro, Eva-Mari; Bavel, Bert van; Escudero, Carlos; Funk, Christiane; Heinonen, Jarna; Herfindal, Lars; Lindblad, Peter; Makinen, Sari; Penttilä, Merja; Sivonen, Kaarina; Chauton, Matilde Skogen; Skomedal, Hanne; Skjermo, Jorunn (Journal article; Peer reviewed, 2021)

  NordAqua is a multidisciplinary Nordic Center of Excellence funded by NordForsk Bioeconomy program (2017–2022). The research center promotes Blue Bioeconomy and endeavours to reform the use of natural resources in a ...

• Spirometry in chronic obstructive pulmonary disease in Norwegian general practice 

  Tollånes, Mette Christophersen; Sjaastad, Geir E.; Aarli, Bernt Bøgvald; Sandberg, Sverre (Journal article; Peer reviewed, 2020)

  Background General practitioners (GPs) in Norway increasingly use spirometry diagnostically as well as in follow up of patients with respiratory complaints, but little is known about their skills and knowledge in this ...

• Discovery of novel candidates for anti- liposarcoma therapies by medium-scale high-throughput drug screening 

  Grad, Iwona; Hanes, Robert; Ayuda-Durán, Pilar; Kuijjer, Marieke Lydia; Enserink, Jorrit; Meza-Zepeda, Leonardo A; Myklebost, Ola (Journal article; Peer reviewed, 2021)

  Sarcomas are a heterogeneous group of mesenchymal orphan cancers and new treatment alternatives beyond traditional chemotherapeutic regimes are much needed. So far, tumor mutation analysis has not led to significant treatment ...

• Association between frailty and self-reported health following heart valve surgery 

  Borregaard, Britt; Dahl, Jordi S.; Lauck, Sandra B.; Ryg, Jesper; Berg, Selina K; Ekholm, Ola; Hendriks, Jeroen M.; Riber, Lars P. S.; Norekvål, Tone M.; Møller, Jacob E. (Journal article; Peer reviewed, 2020)

  Background Knowledge about the association between frailty and self-reported health among patients undergoing heart valve surgery remains sparse. Thus, the objectives were to I) describe changes in self-reported health ...

• A randomized, double-blind, placebo-controlled clinical study to investigate the efficacy of herring roe oil for treatment of psoriasis 

  Tveit, Kåre Steinar; Brokstad, Karl Albert; Berge, Rolf Kristian; Sæbø, Per Christian; Hallaråker, Hogne; Brekke, Stian; Meland, Nils; Bjørndal, Bodil (Journal article; Peer reviewed, 2020-05-07)

  The effect of omega-3 polyunsaturated fatty acid supplements in patients with psoriasis vulgaris has previously been investigated, but interventions varied in source, composition, dose, administration route and duration ...

• Decidual and placental NOD1 is associated with inflammation in normal and preeclamptic pregnancies 

  Rakner, Johanne Johnsen; Silva, Gabriela; Mundal, Siv Boon; Thaning, Astrid Josefin; Elschot, Mattijs; Ostrop, Jenny; Thomsen, Liv Cecilie Vestrheim; Bjørge, Line; Gierman, Lobke; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2021-01-20)

  Introduction: Inflammation is a normal physiological process that increases to harmful levels in preeclampsia. It affects the interaction between maternal immune cells and fetal trophoblasts at both sites of the maternal-fetal ...

• Bile Acid Profiles in Primary Sclerosing Cholangitis and their Ability to Predict Hepatic Decompensation 

  Mousa, Omar Y; Juran, Brian D; McCauley, Bryan M.; Vesterhus, Mette; Folseraas, Trine; Turgeon, Coleman T.; Ali, Ahmad; Schlicht, Erik M; Atkinson, Elizabeth J; Hu, Chang; Harnois, Denise; Carey, Elizabeth J; Gossard, Andrea A; Oglesbee, Devin; Eaton, John E; LaRusso, Nicholas F.; Gores, Gregory J.; Karlsen, Tom Hemming; Lazaridis, Konstantinos N. (Journal article; Peer reviewed, 2020)

  Background and Aims: Altered bile acid (BA) homeostasis is an intrinsic facet of cholestatic liver diseases, but clinical usefulness of plasma BA assessment in primary sclerosing cholangitis (PSC) remains understudied. We ...

• Pentraxin 3 in primary percutaneous coronary intervention for ST elevation myocardial infarction is associated with early irreversible myocardial damage: Kinetic profile, relationship to interleukin 6 and infarct size 

  Butt, Noreen; Bache-Mathiesen, Lena Kristin; Ushakova, Anastasia; Nordrehaug, Jan Erik; Jensen, Senn-Erik; Munk, Peter Scott; Danchin, N; Dubois-Rande, Jean-Luc; Hansen, HS; Paganelli, F; Le Corvoisier, P; Firat, H; Erlinge, David; Atar, Dan; Larsen, Alf Inge (Journal article; Peer reviewed, 2020)

  Background: The inflammatory marker long pentraxin 3 (PTX3) has been shown to be a strong predictor of 30-day and one-year mortality after acute myocardial infarction. The aim of this study was to evaluate the kinetic ...

• Systemic Cardiac Troponin T Associated With Incident Atrial Fibrillation Among Patients With Suspected Stable Angina Pectoris 

  Vavik, Vegard; Pedersen, Eva Ringdal; Svingen, Gard Frodahl Tveitevåg; Solheim, Eivind; Aakre, Kristin Moberg; Tell, Grethe S.; Nygård, Ottar; Vikenes, Kjell (Journal article; Peer reviewed, 2020)

  Higher concentrations of cardiac troponin T are associated with coronary artery disease (CAD) and adverse cardiovascular prognosis. The relation with incident atrial fibrillation (AF) is less explored. We studied this ...

• Sex differences in oncogenic mutational processes 

  Li, Constance H.; Prokopec, Stephenie D.; Sun, Ren X.; Yousif, Fouad; Schmitz, Nathaniel; Boutros, Paul C.; Aure, Miriam Ragle; Børresen-Dale, Anne-Lise; Langerød, Anita; Wright, Derek W.; Baumhoer, Daniel; Bjerkehagen, Bodil; Garred, Øystein; Lingjærde, Ole Christian; Sauer, Torill; Zaikova, Olga; Myklebost, Ola; Knappskog, Stian; Vazquez, Miguel; Van Loo, Peter (Journal article; Peer reviewed, 2020)

  Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features ...

• Comprehensive assessment of ECM turnover using serum biomarkers establishes PBC as a high-turnover autoimmune liver disease 

  Vesterhus, Mette; Nielsen, Mette; Hov, Johannes Espolin Roksund; Saffioti, Francesca; Manon-Jensen, Tina; Leeming, Diana Julie; Moum, Bjørn; Boberg, Kirsten Muri; Pinzani, Massimo; Karlsen, Tom Hemming; Karsdal, Morten A; Thorburn, Douglas (Journal article; Peer reviewed, 2021)

  Background & Aims: Primary sclerosing cholangitis (PSC), primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH) are phenotypically distinct autoimmune liver diseases that progress to cirrhosis and liver failure; ...

• Bedtime Salivary Cortisol as a Screening Test for Cushing Syndrome in Children 

  Ueland, Grethe Åstrøm; Kellmann, Ralf; Davidsen, Melissa Jørstad; Viste, Kristin; Husebye, Eystein Sverre; Almås, Bjørg; Storr, Helen L.; Sagen, Jørn Vegard; Mellgren, Gunnar; Juliusson, Pétur Benedikt; Methlie, Paal (Journal article; Peer reviewed, 2021)

  Background Diagnosing Cushing syndrome (CS) can be challenging. The 24-hour urine free cortisol (UFC) measurement is considered gold standard. This is a laborious test, dependent on correct urine collection. Late-night ...

• Food Sources Contributing to Intake of Choline and Individual Choline Forms in a Norwegian Cohort of Patients With Stable Angina Pectoris 

  van Parys, Anthea; Karlsson, Therese; Vinknes, Kathrine; Olsen, Thomas; Øyen, Jannike; Dierkes, Jutta; Nygård, Ottar Kjell; Lysne, Vegard (Journal article; Peer reviewed, 2021)

  Background: Choline is an essential nutrient involved in a wide range of physiological functions. It occurs in water- and lipid-soluble forms in the body and diet. Foods with a known high choline content are eggs, beef, ...

• Responsiveness to influenza vaccination correlates with NKG2C-expression on NK cells 

  Riese, Peggy; Trittel, Stephanie; Pathirana, Rishi; Klawonn, Frank; Cox, Rebecca Jane; Guzmán, Carlos A. (Journal article; Peer reviewed, 2020-06-05)

  Influenza vaccination often results in a large percentage of low responders, especially in high-risk groups. As a first line of defense, natural killer (NK) cells play a crucial role in the fight against infections. However, ...

• Low Z-4OHtam concentrations are associated with adverse clinical outcome among early stage premenopausal breast cancer patients treated with adjuvant tamoxifen 

  Helland, Thomas; Naume, Bjørn; Hustad, Steinar; Bifulco, Ersilia; Kvaløy, Jan Terje; Sætersdal, Anna Barbro; Synnestvedt, Marit; Lende, Tone Hoel; Gilje, Bjørnar; Mjaaland, Ingvil; Weyde, Kjetil; Blix, Egil Støre; Wiedswang, Gro; Borgen, Elin; Hertz, Daniel Louis; Janssen, Emiel; Mellgren, Gunnar; Søiland, Håvard (Journal article; Peer reviewed, 2021)

  Low steady‐state levels of active tamoxifen metabolites have been associated with inferior treatment outcomes. In this retrospective analysis of 406 estrogen receptor‐positive breast cancer (BC) patients receiving adjuvant ...

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