• Osteopontin characterizes bile duct-associated macrophages and correlates with liver fibrosis severity in primary sclerosing cholangitis 

  De Muynck, Kevin; Heyerick, Lander; De Ponti, Federico F.; Vanderborght, Bart; Meese, Tim; Van Campenhout, Sanne; Baudonck, Leen; Gijbels, Eva; Rodrigues, Pedro M.; Banales, Jesus M.; Vesterhus, Mette Nåmdal; Folseraas, Trine; Scott, Charlotte L.; Vinken, Mathieu; Van Der Linden, Malaïka; Hoorens, Anne; Van Dorpe, Jo; Lefere, Sander; Geerts, Anja; Van Nieuwerburgh, Filip; Verhelst, Xavier; Van Vlierberghe, Hans; Devisscher, Lindsey (Journal article; Peer reviewed, 2024)

  Background and Aims: Primary sclerosing cholangitis (PSC) is an immune-mediated cholestatic liver disease for which pharmacological treatment options are currently unavailable. PSC is strongly associated with colitis ...

• First trans-diagnostic experiences with a novel micro-choice based concentrated group rehabilitation for patients with low back pain, long COVID, and type 2 diabetes: a pilot study 

  Kvale, Gerd; Søfteland, Eirik; Jürgensen, Marte; Wilhelmsen-Langeland, Ane; Haugstvedt, Anne; Hystad, Sigurd William; Ødegaard-Olsen, Øystein Theodor; Aarli, Bernt Bøgvald; Rykken, Sidsel; Frisk, Bente (Journal article; Peer reviewed, 2024)

  Background The health care is likely to break down unless we are able to increase the level of functioning for the growing number of patients with complex, chronic illnesses. Hence, novel high-capacity and cost-effective ...

• Whole blood RNA sequencing identifies transcriptional differences between primary sclerosing cholangitis and ulcerative colitis 

  Wacker, Eike Matthias; Uellendahl-Werth, Florian; Bej, Saptarshi; Wolkenhauer, Olaf; Vesterhus, Mette Nåmdal; Lieb, Wolfgang; Franke, Andre; Karlsen, Tom Hemming; Folseraas, Trine; Ellinghaus, David (Journal article; Peer reviewed, 2024)

  Background & Aims: Genetic and microbiome studies across patients with primary sclerosing cholangitis (PSC) and ulcerative colitis (UC) have indicated that UC in PSC is a separate disease entity to primary UC, but expression ...

• Rough operators: sphingomyelinase inhibitors spike NK cells to kill cancer 

  Carlsten, Mattias; Bryceson, Yenan (Journal article; Peer reviewed, 2023)

• Endovascular treatment in the elderly 

  Rezai Kallaj, Mehdi (Doctoral thesis, 2024-09-13)

  Bakgrunn Nevrologiske lidelser utgjør en stor helsemessig utfordring og hjerneslag er globalt sett den nest hyppigste årsaken til død og den fremste årsaken til uførhet. Iskemisk hjerneslag behandles primært med medisinsk ...

• Streptococcus dysgalactiae Bloodstream Infections, Norway, 1999-2021 

  Oppegaard, Oddvar; Glambek, Marte; Skutlaberg, Dag Harald; Skrede, Steinar; Sivertsen, Audun; Kittang, Bård Reiakvam (Journal article; Peer reviewed, 2023)

  Streptococcus dysgalactiae increasingly is recognized as a pathogen of concern for human health. However, longitudinal surveillance data describing temporal trends of S. dysgalactiae are scarce. We retrospectively identified ...

• Imaging tumor lactate is feasible for identifying intermediate-risk prostate cancer patients with postsurgical biochemical recurrence 

  Sushentsev, Nikita; Hamm, Gregory; Richings, Jack; McLean, Mary A.; Menih, Ines Horvat; Ayyappan, Vinay; Mills, Ian Geoffrey; Warren, Anne Y.; Gnanapragasam, Vincent J.; Barry, Simon T.; Goodwin, Richard J.A.; Gallagher, Ferdia A.; Barrett, Tristan (Journal article; Peer reviewed, 2023)

  While radical prostatectomy remains the mainstay of prostate cancer (PCa) treatment, 20 to 40% of patients develop postsurgical biochemical recurrence (BCR). A particularly challenging clinical cohort includes patients ...

• Mutation Spectrum in Liquid Versus Solid Biopsies From Patients With Advanced astroenteropancreatic Neuroendocrine Carcinoma 

  Knappskog, Stian; Grob, Tobias; Venizelos, Andreas; Amstutz, Ursula; Hjortland, Geir Olav; Lothe, Inger Marie Bowitz; Kersten, Christian; Hofsli, Eva; Sundlöv, Anna; Elvebakken, Hege; Garresori, Herish; Couvelard, Anne; Svensson, Johanna; Sorbye, Halfdan; Perren, Aurel (Journal article; Peer reviewed, 2023)

  Purpose Gastroenteropancreatic neuroendocrine carcinomas (GEP-NEC) are rare and have a poor prognosis. Most GEP-NEC are diagnosed with metastatic disease, with only minor biopsies available for molecular diagnostics. We ...

• Outcomes of Patients With Graves Disease 25 Years After Initiating Antithyroid Drug Therapy 

  Stokland, Ann-Elin Meling; Austdal, Marie; Nedrebø, Bjørn Gunnar; Carlsen, Siri; Hetland, Hanne Brit; Breivik, Lars Ertesvåg; Ueland, Hans Olav; Watt, Torquil; Cramon, Per Karkov; Løvås, Kristian; Husebye, Eystein Sverre; Ueland, Grethe Åstrøm (Journal article; Peer reviewed, 2023)

  Context Graves disease (GD) is a leading cause of hyperthyroidism. Detailed investigations and predictors of long-term outcomes are missing. Objective This work aimed to investigate the outcomes in GD 25 years after ...

• The impact of gingivitis reduction on lung function: a randomized trial under intensified oral hygiene 

  Kühnisch, Jan; Zhao, Tianyu; Bertelsen, Randi Jacobsen; Jörres, Rudolf A.; Nowak, Dennis; Heinrich, Joachim (Journal article; Peer reviewed, 2023)

  Background Periodontal disease and lung function impairment were found to be associated with low-grade systemic or local inflammation, and it might be that gingival/periodontal inflammation triggers lung function due ...

• Adult presentation of ornithine transcarbamylase deficiency: a possible cause of hyperammonemia after high-dose chemotherapy and stem cell transplantation 

  Tsykunova, Galina; Kristensen, Erle; Stray-Pedersen, Asbjørg; Bruserud, Øyvind; Sørensen, Ida Wiig; Bruserud, Øystein; Tvedt, Tor Henrik Anderson (Journal article; Peer reviewed, 2023)

  Hyperammonemia is a rare and often fatal complication following the conditioning therapy in autologous and allogeneic stem cell transplant recipients. It is characterized by anorexia, vomiting, lethargy and coma without ...

• Oral bacterial composition associated with lung function and lung inflammation in a community-based Norwegian population 

  Shigdel, Rajesh; Johannessen, Ane; Lin, Huang; Peddada, Shyamal D.; Gomez Real, Francisco; Ringel-Kulka, Tamar; Svanes, Cecilie; Bertelsen, Randi Jacobsen (Journal article; Peer reviewed, 2023)

  Background The oral cavity is the gateway to the bacteria community in the lung. Disruption of the symbiotic balance of the oral microbiota has been associated with respiratory diseases. However, little is known about ...

• Excess non-COVID-19 mortality in Norway 2020–2022 

  Raknes, Guttorm; Fagerås, Stephanie Jebsen; Sveen, Kari Anne; Juliusson, Pétur Benedikt; Strøm, Marianne Sørlie (Journal article; Peer reviewed, 2024)

  Background Causes of death other than COVID-19 seem to contribute significantly to the excess mortality observed during the 2020–2022 pandemic. In this study, we explore changes in non-COVID-19 causes of death in Norway ...

• Bloodstream infections and antimicrobial resistance in Zanzibar, Tanzania, with special focus on typhoid fever and malaria 

  Onken, Annette (Doctoral thesis, 2024-08-27)

  Bakgrunn: Globalt bidrar infeksjonssykdommer signifikant til sykdom og død, og lavinntektsland er uforholdsmessig rammet. Ved livstruende infeksjoner som blodbaneinfeksjoner kan rask behandling med adekvate legemidler redde ...

• Prevalence and antimicrobial resistance of microbes causing bloodstream infections in Unguja, Zanzibar 

  Onken, Annette; Aboud, Said; Jørstad, Melissa Davidsen; Jenum, Pål; Blomberg, Bjørn (Journal article; Peer reviewed, 2015)

  Background: Bloodstream infections (BSI) are frequent and cause high case-fatality rates. Urgent antibiotic treatment can save patients’ lives, but antibiotic resistance can render antibiotic therapy futile. This study is ...

• Predominance of multidrug-resistant Salmonella Typhi genotype 4.3.1 with low-level ciprofloxacin resistance in Zanzibar 

  Onken, Annette; Moyo, Sabrina John; Miraji, Mohammed Khamis; Bohlin, Jon; Marijani, Msafiri; Manyahi, Joel; Kibwana, Kibwana Omar; Müller, Fredrik; Jenum, Pål; Abeid, Khamis Ali; Reimers, Marianne; Langeland, Nina; Mørch, Kristine; Blomberg, Bjørn (Journal article; Peer reviewed, 2024-04-17)

  Background: Typhoid fever is a common cause of febrile illness in low- and middle-income countries. While multidrug-resistant (MDR) Salmonella Typhi (S. Typhi) has spread globally, fluoroquinolone resistance has mainly ...

• Comparative Study of Cubosome Encapsulation for Antimalarial Drugs with Diverse Physiochemical Properties 

  Gao, Huawei Benjamin (Master thesis, 2024-05-28)

  This study investigated the drug loading (DL) and encapsulation efficiency (EE) of antimalarial drugs with varying hydrophobicity in glycerol monooleate-based cubosomes stabilized with dα-tocopherol polyethylene glycol ...

• Undersøkelse av formuleringstekniske aspekter for Krembase NAF og Krembase NAF som grunnlag i magistrell fremstilling 

  Skadberg, Ragnhild (Master thesis, 2024-06-03)

  Krembase NAF er et produkt med lang historie i norske apotek, men det er likevel begrenset informasjon tilgjengelig om de formuleringstekniske egenskapene. I denne oppgaven er derfor formuleringens robusthet undersøkt, og ...

• The impact of a strict 12-week low-FODMAP diet on circulating cytokines, tryptase, IL-2R, and occludin in irritable bowel syndrome. 

  Mammo, Redate (Master thesis, 2024-06-04)

• Impact of fish oil on the toxic effects of selected persistent organic pollutants in C57BL/6J mice 

  Iversen, Maren (Master thesis, 2024-05-21)

  Abstract Dioxins, polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) are persistent toxicants which can accumulate in the food chain and cause a potential hazard for humans through their diet. For ...

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