• Bile Acid Profiles in Primary Sclerosing Cholangitis and their Ability to Predict Hepatic Decompensation 

  Mousa, Omar Y; Juran, Brian D; McCauley, Bryan M.; Vesterhus, Mette; Folseraas, Trine; Turgeon, Coleman T.; Ali, Ahmad; Schlicht, Erik M; Atkinson, Elizabeth J; Hu, Chang; Harnois, Denise; Carey, Elizabeth J; Gossard, Andrea A; Oglesbee, Devin; Eaton, John E; LaRusso, Nicholas F.; Gores, Gregory J.; Karlsen, Tom Hemming; Lazaridis, Konstantinos N. (Journal article; Peer reviewed, 2020)

  Background and Aims: Altered bile acid (BA) homeostasis is an intrinsic facet of cholestatic liver diseases, but clinical usefulness of plasma BA assessment in primary sclerosing cholangitis (PSC) remains understudied. We ...

• Pentraxin 3 in primary percutaneous coronary intervention for ST elevation myocardial infarction is associated with early irreversible myocardial damage: Kinetic profile, relationship to interleukin 6 and infarct size 

  Butt, Noreen; Bache-Mathiesen, Lena Kristin; Ushakova, Anastasia; Nordrehaug, Jan Erik; Jensen, Senn-Erik; Munk, Peter Scott; Danchin, N; Dubois-Rande, Jean-Luc; Hansen, HS; Paganelli, F; Le Corvoisier, P; Firat, H; Erlinge, David; Atar, Dan; Larsen, Alf Inge (Journal article; Peer reviewed, 2020)

  Background: The inflammatory marker long pentraxin 3 (PTX3) has been shown to be a strong predictor of 30-day and one-year mortality after acute myocardial infarction. The aim of this study was to evaluate the kinetic ...

• Systemic Cardiac Troponin T Associated With Incident Atrial Fibrillation Among Patients With Suspected Stable Angina Pectoris 

  Vavik, Vegard; Pedersen, Eva Ringdal; Svingen, Gard Frodahl Tveitevåg; Solheim, Eivind; Aakre, Kristin Moberg; Tell, Grethe S.; Nygård, Ottar; Vikenes, Kjell (Journal article; Peer reviewed, 2020)

  Higher concentrations of cardiac troponin T are associated with coronary artery disease (CAD) and adverse cardiovascular prognosis. The relation with incident atrial fibrillation (AF) is less explored. We studied this ...

• Sex differences in oncogenic mutational processes 

  Li, Constance H.; Prokopec, Stephenie D.; Sun, Ren X.; Yousif, Fouad; Schmitz, Nathaniel; Boutros, Paul C.; Aure, Miriam Ragle; Børresen-Dale, Anne-Lise; Langerød, Anita; Wright, Derek W.; Baumhoer, Daniel; Bjerkehagen, Bodil; Garred, Øystein; Lingjærde, Ole Christian; Sauer, Torill; Zaikova, Olga; Myklebost, Ola; Knappskog, Stian; Vazquez, Miguel; Van Loo, Peter (Journal article; Peer reviewed, 2020)

  Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features ...

• Comprehensive assessment of ECM turnover using serum biomarkers establishes PBC as a high-turnover autoimmune liver disease 

  Vesterhus, Mette; Nielsen, Mette; Hov, Johannes Espolin Roksund; Saffioti, Francesca; Manon-Jensen, Tina; Leeming, Diana Julie; Moum, Bjørn; Boberg, Kirsten Muri; Pinzani, Massimo; Karlsen, Tom Hemming; Karsdal, Morten A; Thorburn, Douglas (Journal article; Peer reviewed, 2021)

  Background & Aims: Primary sclerosing cholangitis (PSC), primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH) are phenotypically distinct autoimmune liver diseases that progress to cirrhosis and liver failure; ...

• Bedtime Salivary Cortisol as a Screening Test for Cushing Syndrome in Children 

  Ueland, Grethe Åstrøm; Kellmann, Ralf; Davidsen, Melissa Jørstad; Viste, Kristin; Husebye, Eystein Sverre; Almås, Bjørg; Storr, Helen L.; Sagen, Jørn Vegard; Mellgren, Gunnar; Juliusson, Pétur Benedikt; Methlie, Paal (Journal article; Peer reviewed, 2021)

  Background Diagnosing Cushing syndrome (CS) can be challenging. The 24-hour urine free cortisol (UFC) measurement is considered gold standard. This is a laborious test, dependent on correct urine collection. Late-night ...

• Food Sources Contributing to Intake of Choline and Individual Choline Forms in a Norwegian Cohort of Patients With Stable Angina Pectoris 

  van Parys, Anthea; Karlsson, Therese; Vinknes, Kathrine; Olsen, Thomas; Øyen, Jannike; Dierkes, Jutta; Nygård, Ottar Kjell; Lysne, Vegard (Journal article; Peer reviewed, 2021)

  Background: Choline is an essential nutrient involved in a wide range of physiological functions. It occurs in water- and lipid-soluble forms in the body and diet. Foods with a known high choline content are eggs, beef, ...

• Responsiveness to influenza vaccination correlates with NKG2C-expression on NK cells 

  Riese, Peggy; Trittel, Stephanie; Pathirana, Rishi; Klawonn, Frank; Cox, Rebecca Jane; Guzmán, Carlos A. (Journal article; Peer reviewed, 2020-06-05)

  Influenza vaccination often results in a large percentage of low responders, especially in high-risk groups. As a first line of defense, natural killer (NK) cells play a crucial role in the fight against infections. However, ...

• Low Z-4OHtam concentrations are associated with adverse clinical outcome among early stage premenopausal breast cancer patients treated with adjuvant tamoxifen 

  Helland, Thomas; Naume, Bjørn; Hustad, Steinar; Bifulco, Ersilia; Kvaløy, Jan Terje; Sætersdal, Anna Barbro; Synnestvedt, Marit; Lende, Tone Hoel; Gilje, Bjørnar; Mjaaland, Ingvil; Weyde, Kjetil; Blix, Egil Støre; Wiedswang, Gro; Borgen, Elin; Hertz, Daniel Louis; Janssen, Emiel; Mellgren, Gunnar; Søiland, Håvard (Journal article; Peer reviewed, 2021)

  Low steady‐state levels of active tamoxifen metabolites have been associated with inferior treatment outcomes. In this retrospective analysis of 406 estrogen receptor‐positive breast cancer (BC) patients receiving adjuvant ...

• Protected sampling is preferable in bronchoscopic studies of the airway microbiome 

  Grønseth, Rune; Drengenes, Christine; Wiker, Harald G; Tangedal, Solveig; Xue, Yaxin; Husebø, Gunnar; Svanes, Øistein; Lehmann, Sverre; Aardal, Marit Elisabeth; Hoang, Tuyen; Kalananthan, Tharmini; Martinsen, Einar Marius Hjellestad; Leiten, Elise Orvedal; Aanerud, Marianne; Nordeide, Eli; Haaland, Ingvild; Jonassen, Inge; Bakke, Per S.; Eagan, Tomas Mikal (Journal article; Peer reviewed, 2017)

  The aim was to evaluate susceptibility of oropharyngeal contamination with various bronchoscopic sampling techniques. 67 patients with obstructive lung disease and 58 control subjects underwent bronchoscopy with ...

• The genetic architecture of sporadic and multiple consecutive miscarriage 

  Laisk, Triin; Soares, Ana Luiza G.; Ferreira, Teresa; Painter, Jodie N.; Censin, Jenny C.; Laber, Samantha; Bacelis, Jonas; Chen, Chia-Yen; Lepamets, Maarja; Lin, Kuang; Liu, Siyang; Millwood, Iona Y.; Ramu, Avinash; Southcombe, Jennifer; Andersen, Marianne S.; Yang, Ling; Becker, Christian M.; Børglum, Anders D.; Gordon, Scott D.; Bybjerg-Grauholm, Jonas; Helgeland, Øyvind; Hougaard, David M.; Jin, Xin; Johansson, Stefan; Juodakis, Julius; Kartsonaki, Christina; Kukushkina, Viktorija; Lind, Penelope A.; Metspalu, Andres; Montgomery, Grant W.; Morris, Andrew P.; Mors, Ole; Mortensen, Preben B.; Njølstad, Pål Rasmus; Nordentoft, Merete; Nyholt, Dale R.; Lippincott, Margaret; Seminara, Stephanie; Salumets, Andres; Snieder, Harold; Zondervan, Krina; Werge, Thomas; Chen, Zhengming; Conrad, Donald F.; Jacobsson, Bo; Li, Liming; Martin, Nicholas G.; Neale, Benjamin M.; Nielsen, Rasmus; Walters, Robin G. (Journal article; Peer reviewed, 2020)

  Miscarriage is a common, complex trait affecting ~15% of clinically confirmed pregnancies. Here we present the results of large-scale genetic association analyses with 69,054 cases from five different ancestries for sporadic ...

• Prospects and challenges in the development of universal influenza vaccines 

  Madsen, Anders; Brokstad, Rebecca Jane Cox (Journal article; Peer reviewed, 2020-07-06)

  Current influenza vaccines offer suboptimal protection and depend on annual reformulation and yearly administration. Vaccine technology has rapidly advanced during the last decade, facilitating development of next-generation ...

• Altered Gut Microbial Metabolism of Essential Nutrients in Primary Sclerosing Cholangitis 

  Kummen, Martin; Thingholm, Louise B.; Rühlemann, Malte C.; Holm, Kristian; Hansen, Simen Hyll; Moitinho-Silva, Lucas; Liwinski, Timur; Zenouzi, Roman; Larsen, Christopher Storm; Midttun, Øivind; McCann, Adrian; Ueland, Per Magne; Høivik, Marte Lie; Vesterhus, Mette; Trøseid, Marius; Laudes, Matthias; Lieb, Wolfgang; Karlsen, Tom Hemming; Bang, Corinna; Schramm, Christoph; Franke, Andre; Hov, Johannes Espolin Roksund (Journal article; Peer reviewed, 2021)

  Background & Aims To influence host and disease phenotype, compositional microbiome changes, which have been demonstrated in patients with primary sclerosing cholangitis (PSC), must be accompanied by functional changes. ...

• CDX2: A Prognostic Marker in Metastatic Colorectal Cancer Defining a Better BRAF Mutated and a Worse KRAS Mutated Subgroup 

  Aasebø, Kristine; Dragomir, Anca; Sundström, Magnus; Mezheyeuski, Artur; Edqvist, Per-Henrik; Eide, Geir Egil; Pontén, Fredrik; Pfeiffer, Per; Glimelius, Bengt; Sorbye, Halfdan (Journal article; Peer reviewed, 2020-02-11)

  Background: Survival of metastatic colorectal cancer (mCRC) patients has improved, but mainly for trial patients. New predictive and prognostic biomarkers validated in the general mCRC population are needed. Caudal-type ...

• Predicting physical activity in a national cohort of children born extremely preterm 

  Engan, Mette; Engeseth, Merete Salveson; Fevang, Silje Katrine Elgen; Vollsæter, Maria; Eide, Geir Egil; Røksund, Ola Drange; Halvorsen, Thomas; Clemm, Hege Havstad (Journal article; Peer reviewed, 2020)

  Predicting physical activity in a national cohort of children born extremely preterm. Objectives To compare physical activity among school-aged children born extremely preterm or with extremely low birthweight (EP/ELBW) ...

• Reliability of maximum oxygen uptake in cardiopulmonary exercise testing with continuous laryngoscopy 

  Engan, Mette; Jansrud, Ida; Bekken, Marianne; Halvorsen, Thomas; Fretheim-Kelly, Zoe Louise; Vollsæter, Maria; Bovim, Lars Peder Vatshelle; Røksund, Ola Drange; Clemm, Hege Havstad (Journal article; Peer reviewed, 2020)

  Aims A cardiopulmonary exercise test (CPET) is the gold standard to evaluate symptom-limiting exercise intolerance, while continuous laryngoscopy performed during exercise (CLE) is required to diagnose exercise-induced ...

• Respiratory symptoms and mortality in four general population cohorts over 45 years 

  Gulsvik, Amund; Bakke, Per; Brøgger, Jan; Nielsen, Rune; Stavem, Knut (Journal article; Peer reviewed, 2020)

  Objective: This study assessed the association between respiratory symptoms and mortality in four cohorts of the general population in Norway aged 15–75 years and in selected subgroups in the pooled sample. Methods: The ...

• Parents’ smoking onset before conception as related to body mass index and fat mass in adult offspring: Findings from the RHINESSA generation study 

  Knudsen, Gerd Toril Mørkve; Dharmage, Shyamali C.; Janson, Christer; Abramson, Michael J.; Benediktsdóttir, Bryndís; Malinovschi, Andrei; Skulstad, Svein Magne; Bertelsen, Randi Jacobsen; Real, Francisco Gomez; Schlünssen, Vivi; Jögi, Nils Oskar; Sánchez-Ramos, José Luis; Holm, Mathias; Garcia-Aymerich, Judith; Forsberg, Bertil; Svanes, Cecilie; Johannessen, Ane (Journal article; Peer reviewed, 2020)

  Emerging evidence suggests that parents’ preconception exposures may influence offspring health. We aimed to investigate maternal and paternal smoking onset in specific time windows in relation to offspring body mass index ...

• Low risk pregnancies after a cesarean section: Determinants of trial of labor and its failure 

  Lehmann, Sjur; Baghestan, Elham; Børdahl, Per E; Irgens, Lorentz M.; Rasmussen, Svein (Journal article; Peer reviewed, 2020-01-13)

  Introduction: In pregnancies after a previous cesarean section (CS), a planned repeat CS delivery has been associated with excess risk of adverse outcome. However, also the alternative, a trial of labor after CS (TOLAC), ...

• Effects of n-3 fatty acid supplementations in elderly patients after myocardial infarction: A randomized controlled trial 

  Kalstad, Are; Myhre, Peder Langeland; Laake, Kristian; Tveit, Sjur Hansen; Schmidt, Erik Berg; Smith, Pål; Nilsen, Dennis W.T.; Tveit, Arnljot; Fagerland, Morten; Solheim, Svein; Seljeflot, Ingebjørg; Arnesen, Harald (Journal article; Peer reviewed, 2021)

  Background: High intake of marine n-3 polyunsaturated fatty acids (PUFA) has been associated with reduced risk of cardiovascular events; however, this has not been confirmed in patients with a recent acute myocardial ...

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