• Quantitative proteomics reveals serum proteome alterations during metastatic disease progression in breast cancer patients 

  Kaur, Jaspreet; Jung, Sung Yun; Austdal, Marie; Arun, Aaditya Krishna; Helland, Thomas; Mellgren, Gunnar; Lende, Tone Hoel; Janssen, Emiel; Søiland, Håvard; Aneja, Ritu (Journal article; Peer reviewed, 2024)

  Background Tumor recurrence and metastatic progression remains the leading cause for breast cancer related mortalities. However, the proteomes of patient- matched primary breast cancer (BC) and metastatic lesions have ...

• Increasing region of interest width reduces neonatal circumferential strain 

  Mørch, Johannes Kjartansson; Kolnes, Elisabeth Horne; Greve, Gottfried; Omdal, Tom Roar; Ebbing, Cathrine; Kessler, Jørg; Khan, Umael (Journal article; Peer reviewed, 2024)

  Objective There is growing interest in speckle tracking echocardiography-derived strain as a measure of left ventricular function in neonates. However, knowledge gaps remain regarding the effect of image acquisition and ...

• Germline variants in patients diagnosed with pediatric soft tissue sarcoma 

  Yndestad, Synnøve; Haugland, Hans Kristian; Goplen, Dorota Katarzyna Pazdyk; Wojcik, Dorota; Knappskog, Stian; Lønning, Per Eystein (Journal article; Peer reviewed, 2024)

  Background: While soft tissue sarcomas affect younger patients, few studies have assessed the distribution of underlying pathogenic germline variants. Patients and methods: We retrospectively identified all pediatric ...

• Decreased T-cell response against latent cytomegalovirus infection does not correlate with anti-IFN autoantibodies in patients with APECED 

  Hetemäki, Iivo; Heikkilä, Nelli; Peterson, Pärt; Kekäläinen, Eliisa; Willcox, Nick; Wolff, Anette Susanne Bøe; Jarva, Hanna; Arstila, T Petteri (Journal article; Peer reviewed, 2024)

  Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is an inborn error of immunity affecting both multiple endocrine organs and susceptibility to candidiasis, each with an autoimmune basis. Recently, ...

• Six-year follow-up of participants in two clinical trials of rituximab or cyclophosphamide in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome 

  Rekeland, Ingrid Gurvin; Sørland, Kari; Neteland, Lisbeth Lykke; Fosså, Alexander; Alme, Kine; Risa, Kristin; Dahl, Olav; Tronstad, Karl Johan; Mella, Olav; Fluge, Øystein (Journal article; Peer reviewed, 2024)

  Objectives In this six-year follow-up study, we used patient-reported outcome measures (PROMs) to compare values at baseline, at 18 months, and at six-year follow up from the CycloME and the RituxME trials. Methods Based ...

• Quantified planar collagen distribution in healthy and degenerative mitral valve: biomechanical and clinical implications 

  Sadeghinia, Mohammad Javad; Persson, Robert; Ellensen, Vegard Skalstad; Haaverstad, Rune; Holzapfel, Gerhard; Skallerud, Bjørn Helge; Prot, Victorien Emile; Urheim, Stig (Journal article; Peer reviewed, 2024)

  Degenerative mitral valve disease is a common valvular disease with two arguably distinct phenotypes: fibroelastic deficiency and Barlow’s disease. These phenotypes significantly alter the microstructures of the leaflets, ...

• Expiratory airflow limitation in adults born extremely preterm: A systematic review and meta-analysis 

  Lillebøe, Henriette Lahn-Johannessen; Engeseth, Merete Salveson; Clemm, Hege Synnøve Havstad; Halvorsen, Thomas; Røksund, Ola Drange; Potrebny, Thomas; Vollsæter, Maria (Journal article; Peer reviewed, 2024)

  Extreme preterm (EP) birth, denoting delivery before the onset of the third trimester, interrupts intrauterine development and causes significant early-life pulmonary trauma, thereby posing a lifelong risk to respiratory ...

• α1-Antichymotrypsin Complex (SERPINA3) Is an Independent Predictor of All-Cause but Not Cardiovascular Mortality in Patients Hospitalized for Chest Pain of Suspected Coronary Origin 

  Nilsen, Dennis WT; Aarsetøy, Reidun; Pønitz, Volker; Ueland, Thor; Aukrust, Pål; Michelsen, Annika Elisabet; Andersen, Trygve Brugger; Staines, Harry; Grundt, Heidi (Journal article; Peer reviewed, 2024)

  Introduction: SERPINA3 is an acute phase protein triggered by inflammation. It is upregulated after an acute myocardial infarction (AMI). Data on its long-term prognostic value in MI patients are scarce. We aimed to assess ...

• Monocytic Differentiation in Acute Myeloid Leukemia Cells: Diagnostic Criteria, Biological Heterogeneity, Mitochondrial Metabolism, Resistance to and Induction by Targeted Therapies 

  Bruserud, Øystein; Selheim, Frode; Valladares, Maria del Carmen Hernandez; Reikvam, Håkon (Journal article; Peer reviewed, 2024)

  We review the importance of monocytic differentiation and differentiation induction in non-APL (acute promyelocytic leukemia) variants of acute myeloid leukemia (AML), a malignancy characterized by proliferation of immature ...

• 'When age is not a barrier': an explorative study of nonagenarian patients' experiences of undergoing percutaneous coronary intervention 

  Instenes, Irene; Fridlund, Bengt Gotthard Anton; Borregaard, Britt; Larsen, Alf Inge; Allore, Heather; Bendz, Bjørn; Deaton, Christi; Rotevatn, Svein; Fålun, Nina Britt; Norekvål, Tone Merete (Journal article; Peer reviewed, 2024)

  Aims The recent rise in the number of nonagenarians (age ≥ 90 years) undergoing percutaneous coronary intervention (PCI) has revealed gaps in research, in particular on patients’ experiences. Therefore, the aim of the ...

• Time trends and birth rates in women with congenital heart disease; a nationwide cohort study from Norway 1994–2014 

  Sandberg, Marit; Fomina, Tatiana; Macsali, Ferenc; Greve, Gottfried; Estensen, Mette-Elise; Øyen, Nina; Leirgul, Elisabeth (Journal article; Peer reviewed, 2024)

  Background: More women with congenital heart disease (CHD) reach reproductive age, but little is known of their success in having children. We investigated time trends of CHD in women of reproductive age and maternal CHD ...

• Recurrent laryngeal nerve injury and nerve recovery evaluated by EMG, accelerometry and direct laryngoscopy : -An experimental approach - 

  Setså, Erling Johan (Doctoral thesis, 2024-12-13)

  Den mest fryktede komplikasjonen ved endokrinkirurgi på hals er bilateral skade på nervus laryngeus rekurrens (RLN) som kan føre til lammelse av stemmebåndene, ledsaget av alvorlige respirasjonsproblemer som kan ende i ...

• Lung function in Norway in the 20th century : Trends, lower limits of normality and overall and specific mortalities 

  Cestelli, Lucia (Doctoral thesis, 2024-12-06)

  Bakgrunn og mål: Lungefunksjon er en markør for generell helse og kan predikere mortalitet. Flere faktorer påvirker måling og tolkning av lungefunksjon i en befolkning. Målet med dette doktorgradsarbeidet var å studere den ...

• Preoperative risk factors associated with left ventricular dysfunction after bariatric surgery 

  Grymyr, Lisa Marie Dale; Mellgren, Gunnar; McCann, Adrian; Gerdts, Eva; Meyer, Klaus; Nadirpour, Saied; Fernø, Johan; Nedrebø, Bjørn Gunnar; Cramariuc, Dana (Journal article; Peer reviewed, 2024)

  A large proportion of patients with severe obesity remain with left ventricular (LV) dysfunction after bariatric surgery. We assessed whether preoperative evaluation by echocardiography and inflammatory proteins can identify ...

• Prognostic factors, treatment approach and clinical outcomes from glioblastoma: a population-based observational cohort study from Western Norway 

  Bjorland, Line Sagerup (Doctoral thesis, 2024-12-06)

  Bakgrunn: Glioblastom er den vanligste og mest aggressive primære hjernesvulst hos voksne, og prognosen er svært alvorlig med median overlevelse på omtrent 15 måneder tross standard behandling med radiokjemoterapi. I klinisk ...

• Left ventricular mechanics and oxygen demand in patients with severe obesity undergoing Roux-en-Y gastric bypass surgery 

  Grymyr, Lisa Marie Dale (Doctoral thesis, 2024-11-29)

  Bakgrunn og mål: Venstre ventrikkel (VV) er eksponert for kronisk trykk- og volumoverbelastning ved alvorlig fedme. Effekten av vektreduserende kirurgi på fedme-relatert VV-dysfunksjon har ikke vært kartlagt i detalj ...

• The NORwegian atrial fibrillation self-SCREENing (NORSCREEN) trial: rationale and design of a randomized controlled trial 

  Boskovic, Miroslav; Jortveit, Jarle; Haraldsen, Marius Blørstad; Berge, Trygve; Engdahl, Johan; Løchen, Maja-Lisa; Schuster, Peter Moritz; Sandberg, Edvard Liljedahl; Grimsmo, Jostein; Atar, Dan; Anfinsen, Ole-Gunnar; Pripp, Are Hugo; Grenne, Bjørnar Leangen; Halvorsen, Sigrun (Journal article; Peer reviewed, 2024)

  Aims Atrial fibrillation (AF) is a common arrhythmia, and many cases of AF may be undiagnosed. Whether screening for AF and subsequent treatment if AF is detected can improve long-term outcome remains an unsettled ...

• HyperTraPS-CT: Inference and prediction for accumulation pathways with flexible data and model structures 

  Aga, Olav Nicolay Larsson; Brun, Morten; Dauda, Kazeem Adesina; Diaz-Uriarte, Ramon; Giannakis, Konstantinos; Johnston, Iain (Journal article; Peer reviewed, 2024-09-04)

  Accumulation processes, where many potentially coupled features are acquired over time, occur throughout the sciences from evolutionary biology to disease progression, and particularly in the study of cancer progression. ...

• SARS-CoV-2 infection in healthcare workers, and biomarkers of long COVID 

  Bansal, Amit (Doctoral thesis, 2024-11-27)

  I denne doktorgradsavhandlingen har vi studert risikoen for å bli smittet av SARS-CoV-2 virus blant norske helsearbeidere gjennom de ulike covid-19 smittebølgene. Kunnskap om prevalens og risikofaktorer for smitte hos ...

• Prostate Biopsies Can Be Omitted in Most Patients with a Positive Stockholm3 Test and Negative Prostate Magnetic Resonance Imaging 

  Vinje, Cathrine Alvær; Vigmostad, Maria Nyre; Kjosavik, Svein Reidar; Grönberg, Henrik; Gilje, Bjørnar; Skeie, Svein (Journal article; Peer reviewed, 2024)

  Background Magnetic resonance imaging (MRI) combined with the Stockholm3 test can be used to inform biopsy decision-making in patients with a suspicion of prostate cancer. Objective To determine the consequence of ...

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