Department of Clinical Science
Nye registreringer
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Potential Transcriptional Biomarkers to Guide Glucocorticoid Replacement in Autoimmune Addison's Disease
(Journal article; Peer reviewed, 2021)Background No reliable biomarkers exist to guide glucocorticoid (GC) replacement treatment in autoimmune Addison’s disease (AAD), leading to overtreatment with alarming and persistent side effects or undertreatment, which ... -
Sex-Specific Limitations in Physical Health in Primary Adrenal Insufficiency
(Journal article; Peer reviewed, 2021)Background: Patients with primary adrenal insufficiency (PAI) suffer reduced quality of life (QoL), but comparisons with large-scale normative data are scarce. The clinical characteristics associated with reduced QoL are ... -
Sleep and physical activity from before conception to the end of pregnancy in healthy women: a longitudinal actigraphy study
(Journal article; Peer reviewed, 2021)Background Sleep and physical activity changes are common in pregnancy, but longitudinal data starting before conception are scarce. Our aim was to determine the changes of the daily total sleep time (TST) and physical ... -
Role of Adipocyte SLC7A10 and Amino Acid Metabolism in Obesity and Insulin Resistance
(Doctoral thesis, 2020-12-18)Obesity is a rising global concern, associated with increased risk of developing metabolic syndrome, insulin resistance and type 2 diabetes. Chronic availability of excess nutrients may promote adipocyte dysfunction, ... -
The effect of Zhang’s guideline versus the WHO partograph on childbirth experience measured by the Childbirth Experience Questionnaire in the Labor Progression Study (LaPS): A cluster randomized trial
(Journal article; Peer reviewed, 2021)Introduction Childbirth experience is an increasingly recognized and important measure of quality of obstetric care. Previous research has shown that it can be affected by intrapartum care and how labor is followed. A ... -
A radiogenomics application for prognostic profiling of endometrial cancer
(Journal article; Peer reviewed, 2021)Prognostication is critical for accurate diagnosis and tailored treatment in endometrial cancer (EC). We employed radiogenomics to integrate preoperative magnetic resonance imaging (MRI, n = 487 patients) with histologic-, ... -
Age-related differences in self-report and objective measures of cognitive function in older patients prior to chemotherapy
(Journal article; Peer reviewed, 2021)Aim Evaluate for differences in demographic and clinical characteristics and subjective and objective measures of cognitive function (CF) between younger older adults (YOA, 60–69 years) and older adults (OA, ≥70 ... -
A gene signature identifying CIN3 regression and cervical cancer survival
(Journal article; Peer reviewed, 2021-11-16)The purpose of this study was to establish a gene signature that may predict CIN3 regression and that may aid in selecting patients who may safely refrain from conization. Oncomine mRNA data including 398 immune-related ... -
Attitudes among parents of persons with autism spectrum disorder towards information about genetic risk and future health
(Journal article; Peer reviewed, 2021)Clinical relevance of genetic testing is increasing in autism spectrum disorder (ASD). Information about genetic risk may contribute to improved diagnostics, treatment and family planning, but may also be perceived as a ... -
Analysing microbiome intervention design studies: Comparison of alternative multivariate statistical methods
(Journal article; Peer reviewed, 2021)The diet plays a major role in shaping gut microbiome composition and function in both humans and animals, and dietary intervention trials are often used to investigate and understand these effects. A plethora of statistical ... -
Bioactive peptides from microalgae: Focus on anti-cancer and immunomodulating activity
(Journal article; Peer reviewed, 2021)In addition to the rapidly expanding field of using microalgae for food and feed, microalgae represent a tremendous potential for new bioactive compounds with health-promoting effects. One field where new therapeutics is ... -
Prevalence of long-term mechanical insufflation-exsufflation in children with neurological conditions: a population-based study
(Journal article; Peer reviewed, 2021)Aim: To determine the prevalence of long-term mechanical insufflation-exsufflation (MI-E) and concomitant mechanical ventilation in children with neurological conditions, with reported reasons behind the initiation of ... -
Prediction of type 1 diabetes at birth: Cord blood metabolites vs genetic risk score in the Norwegian mother, father, and child cohort
(Journal article; Peer reviewed, 2021)Background and aim: Genetic markers are established as predictive of type 1 diabetes, but unknown early life environment is believed to be involved. Umbilical cord blood may reflect perinatal metabolism and exposures. We ... -
Chronically elevated exogenous glucose elicits antipodal effects on the proteome signature of differentiating human iPSC-derived pancreatic progenitors
(Journal article; Peer reviewed, 2021-04-02)The past decade revealed that cell identity changes, such as dedifferentiation or transdifferentiation, accompany the insulin-producing β-cell decay in most diabetes conditions. Mapping and controlling the mechanisms ... -
Sex disparity in acute myeloid leukaemia with FLT3 internal tandem duplication mutations: implications for prognosis
(Journal article; Peer reviewed, 2021)Incidence, molecular presentation and outcome of acute myeloid leukaemia (AML) are influenced by sex, but little attention has been directed at untangling sex-related molecular and phenotypic differences between female and ... -
A human iPSC-astroglia neurodevelopmental model reveals divergent transcriptomic patterns in schizophrenia
(Journal article; Peer reviewed, 2021)While neurodevelopmental abnormalities have been associated with schizophrenia (SCZ), the role of astroglia in disease pathophysiology remains poorly understood. In the present study, we used a human induced pluripotent ... -
A whole blood based resuscitation strategy in civilian medical services: Experience from a Norwegian hospital in the period 2017–2020
(Journal article; Peer reviewed, 2021)Background: Civilian and military guidelines recommend early balanced transfusion to patients with life-threatening bleeding. Low titer group O whole blood was introduced as the primary blood product for resuscitation of ... -
Early manifestations of genetic risk for neurodevelopmental disorders
(Journal article; Peer reviewed, 2021)Background: Attention deficit/hyperactivity disorder (ADHD), autism spectrum disorder (autism) and schizophrenia are highly heritable neurodevelopmental disorders, affecting the lives of many individuals. It is important ... -
The natural history of 21-hydroxylase autoantibodies in autoimmune Addison’s disease
(Journal article; Peer reviewed, 2021)Background: The most common cause of primary adrenal failure (Addison’s disease) in the Western world is autoimmunity characterized by autoantibodies against the steroidogenic enzyme 21-hydroxylase (CYP21A2, 21OH). Detection ... -
Chip protein U-box domain truncation affects Purkinje neuron morphology and leads to behavioral changes in zebrafish
(Journal article; Peer reviewed, 2021-09-24)The ubiquitin ligase CHIP (C-terminus of Hsc70-interacting protein) is encoded by STUB1 and promotes ubiquitination of misfolded and damaged proteins. CHIP deficiency has been linked to several diseases, and mutations in ...
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