Department of Clinical Science
Recent Submissions
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Randomized clinical trial to assess whether the duration of cotrimoxazole preventive therapy in HIV patients with CD4 counts >350 CD4 cells/μL by antiretroviral treatment influences the rate of carriage of multidrug-resistant bacteria. Study protocol
(Report, 2016-09-20)Cotrimoxazole preventive therapy (CPT) is recommended for prevention of morbidity and mortality due to Pneumocystis jirovecii pneumonia (PJP) and other infections in HIV positive patients with low immunity. In industrial ... -
Nekrotiserende bløtdelsinfeksjoner
(Journal article; Peer reviewed, 2024)Nekrotiserende bløtdelsinfeksjoner rammer hud, subkutant vev, overfladisk fascie, dyp fascie eller muskulatur. Infeksjonene er alvorlige, sprer seg hurtig og kan medføre omfattende vevstap. De er sjeldne, men har høy ... -
'If you've lost your personality, there's no point in changing the valve'-a qualitative study of older adults' attitudes towards treatment of aortic stenosis with comorbid dementia
(Journal article; Peer reviewed, 2024)Objectives Due to prognostic uncertainty and limited decision-making capacity, the choice to perform transcatheter aortic valve implantation (TAVI) in patients with severe aortic stenosis (AS) and comorbid dementia is ... -
Pre-pregnancy obesity among immigrant and non-immigrant women in Norway: Prevalence, trends, and subgroup variations
(Journal article; Peer reviewed, 2024)Introduction This study assessed prevalence and time trends of pre-pregnancy obesity in immigrant and non-immigrant women in Norway and explored the impact of immigrants' length of residence on pre-pregnancy obesity ... -
Rare copy number variant analysis in case–control studies using snp array data: a scalable and automated data analysis pipeline
(Journal article; Peer reviewed, 2024)Background Rare copy number variants (CNVs) significantly influence the human genome and may contribute to disease susceptibility. High-throughput SNP genotyping platforms provide data that can be used for CNV detection, ... -
An experimental study on intraoperative recovery of recurrent laryngeal nerve function
(Journal article; Peer reviewed, 2020)Objective If bilateral thyroid surgery is planned and staged thyroidectomy considered in case of loss of neuromonitoring signal (LOS), a waiting time of 20 minutes is suggested for evaluation of early nerve recovery. This ... -
Genome-wide analyses of neonatal jaundice reveal a marked departure from adult bilirubin metabolism
(Journal article; Peer reviewed, 2024)Jaundice affects almost all neonates in their first days of life and is caused by the accumulation of bilirubin. Although the core biochemistry of bilirubin metabolism is well understood, it is not clear why some neonates ... -
Impact of the Graphene Production Methods Sonication and Microfluidization on In Vitro and In Vivo Toxicity, Macrophage Response, and Complement Activation
(Journal article; Peer reviewed, 2024)Graphene, a material composed of a two-dimensional lattice of carbon atoms, has due to its many unique properties a wide array of potential applications in the biomedical field. One of the most common production methods ... -
Exposure to Per- and Polyfluoroalkyl Substances and Timing of Puberty in Norwegian Boys: Data from the Bergen Growth Study 2
(Journal article; Peer reviewed, 2024)Per- and polyfluoroalkyl substances (PFAS) are widespread environmental contaminants with endocrine-disruptive properties. Their impact on puberty in boys is unclear. In this cross-sectional study, we investigated the ... -
No signs of mast cell involvement in long-COVID: A case–control study
(Journal article; Peer reviewed, 2024)Long-COVID caused by SARS-CoV-2 infection has significant and increasing effects on human health worldwide. Although a unifying molecular or biological explanation is lacking, several pathophysiological mechanisms have ... -
Secondary Cytoreductive Surgery in Relapsed Platinum-Sensitive Epithelial Ovarian Cancer: A Systematic Review of Randomized Controlled Trials
(Journal article; Peer reviewed, 2024)Secondary cytoreductive surgery is a treatment option for relapsed platinum-sensitive epithelial ovarian cancer, but no clear indications are defined for the procedure. This systematic review aims to establish clear ... -
Hastegradsvurdering av akutt syke barn transportert i ambulanse
(Journal article; Peer reviewed, 2024)BAKGRUNN Helse Vest benytter en modifisert versjon av hastegradsverktøyet South African Triage Scale, SATS Norge (SATS-N), i alle akuttmottak og ambulansetjenester i regionen. Formålet med studien var å undersøke ... -
Impact of Pre-Existing Immunity and Age on Antibody Responses to Live Attenuated Influenza Vaccine
(Journal article; Peer reviewed, 2024-08-01)Live attenuated influenza vaccines (LAIV) typically induce a poor hemagglutination inhibition (HI) response, which is the standard correlate of protection for inactivated influenza vaccines. The significance of the HI ... -
Ultrasensitive Assays for Targeted Breast Cancer Treatment
(Doctoral thesis, 2025-01-23)Den avgjørende rollen til østrogen i østrogenreseptor-positiv (ER+) brystkreft er veletablert, hvor aromatasehemmere som hemmer østrogensyntesen er sentral i behandlingen av brystkreft. Imidlertid er kvantifiseringen av ... -
Assessment of Variables Related to the Risk of Severe Adverse Events in Cutaneous Melanoma Patients Treated with Immune Checkpoint Inhibitors
(Journal article; Peer reviewed, 2024)Malignant melanoma is a prevalent and aggressive cancer, with globally increasing incidences. While immune checkpoint inhibitors (ICIs) have prolonged the survival of patients with advanced melanoma over the last decade, ... -
Compositional plaque progression in women and men with non-obstructive coronary artery disease
(Journal article; Peer reviewed, 2024)Background: In coronary artery disease (CAD), plaque progression and plaque composition are associated with cardiovascular risk. Whether compositional plaque progression in non-obstructive CAD differs between women and men ... -
Use of health services and perceived need for information and follow-up after percutaneous coronary intervention
(Journal article; Peer reviewed, 2024-01-05)Objective Few patients achieve full control of their coronary artery disease (CAD) risk factors. Follow-up, such as cardiac rehabilitation, is important to increase adherence to lifestyle changes and treatment, to improve ... -
Muscle Strength and Male Sexual Function
(Journal article; Peer reviewed, 2024-01-12)Sexual dysfunction, in particular erectile dysfunction, is a common complaint among aging men. Obesity, diabetes, hypertension, and smoking are shown to be independent risk factors for erectile dysfunction, while ... -
Factors associated with progression of arterial stiffness in ischemic stroke survivors: the Norwegian Stroke in the Young Study
(Journal article; Peer reviewed, 2024)Background: Progressive arterial stiffening may increase the risk of recurrent cardiovascular events in ischemic stroke survivors. Information about factors associated with progressive arterial stiffening during the follow-up ...