Department of Clinical Science
Recent Submissions
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Quantitative User Data From a Chatbot Developed for Women With Gestational Diabetes Mellitus: Observational Study
(Journal article; Peer reviewed, 2022)Background: The rising prevalence of gestational diabetes mellitus (GDM) calls for the use of innovative methods to inform and empower these pregnant women. An information chatbot, Dina, was developed for women with GDM ... -
Malaria prevalence and performance of diagnostic tests among patients hospitalized with acute undifferentiated fever in Zanzibar
(Journal article; Peer reviewed, 2022-02-19)Background: Control efforts in Zanzibar reduced the burden of malaria substantially from 2000 to 2015, but re-emergence of falciparum malaria has been observed lately. This study evaluated the prevalence of malaria and ... -
Family-based treatment of children with severe obesity in a public healthcare setting: Results from a randomized controlled trial
(Journal article; Peer reviewed, 2022)To compare the effectiveness of family-based behavioural social facilitation treatment (FBSFT) versus treatment as usual (TAU) in children with severe obesity. Parallel-design, nonblinded, randomized controlled trial ... -
Hepcidin predicts 5-year mortality after community-acquired pneumonia
(Journal article; Peer reviewed, 2022)Background Virtually all living organisms, including microbes and humans, depend on iron to survive and grow. During an infection, the plasma level of iron and several iron-related proteins change substantially. We ... -
The regulation of tyrosine hydroxylase by dopamine and selected binding partners
(Master thesis, 2022-05-20)Tyrosine hydroxylase (TH) catalyses the rate limiting step in the metabolic pathway of dopamine (DA) synthesis and is therefore important in physiological functions such as motor control, cognitive function, and the brain ... -
Humoral and cellular immune responses after pandemic and seasonal influenza vaccination in humans
(Doctoral thesis, 2022-06-22)Vaccination is the most effective prophylaxis against epidemic and pandemic influenza. Annual seasonal influenza vaccination is recommended for high-risk groups such as younger children <5 years old and occupational workers ... -
Screening for modulators of vesicular monoamine transporter 2 activity in cells using a fluorescent substrate
(Master thesis, 2022-05-20)Vesicular monoamine transporter 2 (VMAT2) is an essential protein for transport of monoamine neurotransmitters such as dopamine from the cytosol into synaptic vesicles, packing them for subsequent release into the synaptic ... -
Ascaris exposure and its association with lung function, asthma, and DNA methylation in Northern Europe
(Journal article; Peer reviewed, 2022)Background Ascaris infections, with a worldwide prevalence above 10%, can cause respiratory pathology. However, long-term effects on lung function in humans are largely unknown. Objective We investigated the associations ... -
Predictive and prognostic markers in localized colon cancer : with emphasis on the biomarkers maspin, mismatch repair deficiency, CDX2, tumor grade, PD-L1, and tumor-infiltrating lymphocytes.
(Doctoral thesis, 2022-06-23)Colon cancer is one of the most common cancers worldwide. Predicting disease outcomes is challenging. Around 15-20% of patients will experience disease relapse. At the same time, a substantial fraction of patients will ... -
Thrombus characteristics evaluated by acute optical coherence tomography in ST elevation myocardial Infarction
(Journal article; Peer reviewed, 2022)Aims ST elevation myocardial infarction (STEMI) is caused by an occlusive thrombosis of a coronary artery. We wanted to assess if the thrombus can be characterized according to erythrocyte content and age using intravascular ... -
Asthma, atopy and lung function in young adults after hospitalisation for bronchiolitis in infancy: impact of virus and sex
(Journal article; Peer reviewed, 2022)Background: Hospitalisation for bronchiolitis is a risk factor for asthma and impaired lung function during childhood, but outcomes in young adults are poorly described. Our primary aim was to study the prevalence of asthma ... -
Eosinophilic airway diseases: basic science, clinical manifestations and future challenges
(Journal article; Peer reviewed, 2022)Eosinophils have a broad range of functions, both homeostatic and pathological, mediated through an array of cell surface receptors and specific secretory granules that promote interactions with their microenvironment. ... -
Proteasome‐mediated regulation of GATA2 expression and androgen receptor transcription in benign prostate epithelial cells
(Journal article; Peer reviewed, 2022)GATA2 has been shown to be an important transcription factor together with androgen receptor (AR) in prostate cancer cells. Less is known about GATA2 in benign prostate epithelial cells. We have investigated if GATA2 ... -
Comparison of rapid molecular testing methods for detecting respiratory viruses in emergency care: a prospective study
(Journal article; Peer reviewed, 2022)Background Respiratory tract infections (RTIs) caused by contagious viruses are common among patients presenting to the emergency department (ED). Early detection of these viruses can help prevent nosocomial transmissio ... -
Neuroinflammation Associated With Inborn Errors of Immunity
(Journal article; Peer reviewed, 2022)The advent of high-throughput sequencing has facilitated genotype-phenotype correlations in congenital diseases. This has provided molecular diagnosis and benefited patient management but has also revealed substantial ... -
Glycated albumin in pregnancy: LC-MS/MS-based reference interval in healthy, nulliparous Scandinavian women and its diagnostic accuracy in gestational diabetes mellitus
(Journal article; Peer reviewed, 2022)Glycated albumin (GA) may be a useful biomarker of glycemia in pregnancy. The aim of this study was to establish the reference interval (RI) for GA, analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS), ... -
Subtype-specific surface proteins on adipose tissue macrophages and their association to obesity-induced insulin resistance
(Journal article; Peer reviewed, 2022)A chronic low-grade inflammation, originating in the adipose tissue, is considered a driver of obesity-associated insulin resistance. Macrophage composition in white adipose tissue is believed to contribute to the pathogenesis ... -
Specific depressive symptoms are related with different patterns of alcohol use in community-dwelling older adults
(Journal article; Peer reviewed, 2022)Objectives To explore how individual depressive symptoms might contribute to different patterns of alcohol consumption in Colombian older adults living in the community. Methods A Secondary analysis from a nationally ... -
Relationship between hypertension and nonobstructive coronary artery disease in chronic coronary syndrome (the NORIC registry)
(Journal article; Peer reviewed, 2022)Background The burden of non-obstructive coronary artery disease (CAD) in the society is high, and there is currently limited evidence-based recommendation for risk stratification and treatment. Previous studies have ...
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