Department of Clinical Science
Recent Submissions
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The association between malnutrition and postoperative complications, and the potential for prevention of both
(Doctoral thesis, 2021-04-23)Introduction: Poor nutritional status is an established risk factor for suboptimal outcome of hospital stay, including among other things, an increased risk of postoperative complications. Despite the fact that international ... -
Weight loss and BMI criteria in GLIM's definition of malnutrition is associated with postoperative complications following abdominal resections - Results from a National Quality Registry
(Journal article, 2020)Background & aims: Although malnutrition is thought to be common among patients with intraabdominal diseases and is recognized as a risk factor for postoperative complications, diagnostic criteria for malnutrition have not ... -
Worst lead ST deviation and resolution of ST elevation at one hour for prediction of myocardial salvage, infarct size, and microvascular obstruction in patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention
(Journal article; Peer reviewed, 2020)Background ECG changes after revascularization predicts improved outcome for patients with ST‐elevation myocardial infarction (STEMI). Worst lead residual (WLR) ST deviation and resolution of worst lead ST elevation (rST ... -
New CDK8 inhibitors as potential anti-leukemic agents – Design, synthesis and biological evaluation
(Journal article; Peer reviewed, 2020)Cyclin-dependent kinase 8 (CDK8) plays a vital role in regulating cell transcription either through its association with the mediator complex or by the phosphorylation of transcription factors. CDK8-mediated activation of ... -
Voice and Exercise Related Respiratory Symptoms in Extremely Preterm Born Children After Neonatal Patent Ductus Arteriosus
(Journal article; Peer reviewed, 2020)Objective: To investigate voice characteristics and exercise related respiratory symptoms in extremely preterm born 11-year-old children, focusing particularly on associations with management of a patent ductus arteriosus ... -
Human Leukocyte Antigen alleles associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
(Journal article; Peer reviewed, 2020)The etiology and pathogenesis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) are unknown, and autoimmunity is one of many proposed underlying mechanisms. Human Leukocyte Antigen (HLA) associations are ... -
Impact of the left ventricular lead on the efficacy of Cardiac Resynchronization Therapy for heart failure. : Electrophysiologic and clinical trials investigating active fixation left ventricular lead in cardiac resynchronization therapy.
(Doctoral thesis, 2021-04-09)Background: This thesis examines the performance of different left ventricular (LV) leads and in particular a novel bipolar LV lead with a side helix for active fixation. Cardiac resynchronization therapy (CRT) provides ... -
CD24-targeted intraoperative fluorescence image-guided surgery leads to improved cytoreduction of ovarian cancer in a preclinical orthotopic surgical model
(Journal article; Peer reviewed, 2020)Background The completeness of resection is a key prognostic indicator in patients with ovarian cancer, and the application of tumour-targeted fluorescence image-guided surgery (FIGS) has led to improved detection of ... -
Endurance exercise training volume is not associated with progression of coronary artery calcification
(Journal article; Peer reviewed, 2020)Background Recent cross‐sectional studies have suggested a dose‐dependent relationship between lifelong exposure to physical activity and the burden of calcified coronary artery disease (CAD). No longitudinal studies have ... -
Maternal and child gluten intake and association with type 1 diabetes: The Norwegian Mother and Child Cohort Study
(Journal article; Peer reviewed, 2020)Background The relationship between maternal gluten intake in pregnancy, offspring intake in childhood, and offspring risk of type 1 diabetes has not been examined jointly in any studies. Our aim was to study the relationship ... -
Bone mineral density and vitamin D in paediatric intestinal failure patients receiving home parenteral nutrition
(Journal article; Peer reviewed, 2020)Background & aims Patients with intestinal failure (IF) are dependent on long-term home parenteral nutrition (HPN) to ensure growth and development. The primary aim of the present study was to assess bone mineral density ... -
Cognitive impairment - role of vascular risk factors and lipid alterations for development and progression
(Doctoral thesis, 2021-03-26)Background: Dementia is a growing challenge, and there is no curative treatment available. The most common cause of dementia is Alzheimer’s disease (AD), where treatment studies focusing on anti-amyloid treatment have thus ... -
Increased Plasma Soluble Interleukin-2 Receptor Alpha Levels in Patients With Long-Term Type 1 Diabetes With Vascular Complications Associated With IL2RA and PTPN2 Gene Polymorphisms
(Journal article; Peer reviewed, 2020)Type 1 diabetes (T1D) is largely considered an autoimmune disease leading to the destruction of insulin-producing pancreatic β cells. Further, patients with T1D have 3–4-fold increased risk of developing micro- and ... -
Atherogenic Lipid Ratios Related to Myeloperoxidase and C-Reactive Protein Levels in Psychotic Disorders
(Journal article; Peer reviewed, 2020)Background: Cardiovascular disease (CVD) is a major cause of premature death in patients with psychotic disorders, where dyslipidemia occurs frequently. In the pathogenesis of these serious mental disorders, a low-grade ... -
N-terminal pro-B-type natriuretic peptide as a prognostic indicator for 30-day mortality following out-of-hospital cardiac arrest: A prospective observational study
(Journal article; Peer reviewed, 2020-08-24)Background Early risk stratification applying cardiac biomarkers may prove useful in sudden cardiac arrest patients. We investigated the prognostic utility of early-on levels of high sensitivity cardiac troponin-T (hs-cTnT), ... -
Plasma levels of interleukin 27 in falciparum malaria is increased independently of co-infection with HIV: potential immune-regulatory role during malaria
(Journal article; Peer reviewed, 2020)Background The immune response during falciparum malaria mediates both harmful and protective effects on the host; however the participating molecules have not been fully defined. Interleukin (IL)-27 is a pleiotropic ... -
Rosuvastatin alters the genetic composition of the human gut microbiome
(Journal article; Peer reviewed, 2020)The gut microbiome contributes to the variation of blood lipid levels, and secondary bile acids are associated with the effect of statins. Yet, our knowledge of how statins, one of our most common drug groups, affect the ... -
Plasma parasitemia as assessed by quantitative PCR in relation to clinical disease severity in African adults with falciparum malaria with and without HIV co-infection
(Journal article; Peer reviewed, 2020)Purpose When considering malaria disease severity, estimation of parasitemia in erythrocytes is important, but sometimes misleading, since the infected erythrocytes may be sequestered in peripheral capillaries. In African ... -
Fatigue in primary Sjögren’s syndrome: A proteomic pilot study of cerebrospinal fluid
(Journal article; Peer reviewed, 2019)Objectives: Fatigue is a frequent and often disabling phenomenon that occurs in patients with chronic inflammatory and immunological diseases, and the underlying biological mechanisms are largely unknown. Because fatigue ... -
How does the WHO Surgical Safety Checklist fit with existing perioperative risk management strategies? An ethnographic study across surgical specialties
(Journal article; Peer reviewed, 2020)Background The World Health Organization (WHO) Surgical Safety Checklist (SSC) has demonstrated beneficial impacts on a range of patient- and team outcomes, though variation in SSC implementation and staffʼs perception ...
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