• LRFN5 locus structure is associated with autism and influenced by the sex of the individual and locus conversions 

  Lybæk, Helle; Robson, Michael; de Leeuw, Nicole; Hehir-Kwa, Jayne Y.; Jeffries, Aaron; Haukanes, Bjørn Ivar; Berland, Siren; de Bruijn, Diederik; Mundlos, Stefan; Spielmann, Malte; Houge, Gunnar Douzgos (Journal article; Peer reviewed, 2022)

  LRFN5 is a regulator of synaptic development and the only gene in a 5.4 Mb mammalian-specific conserved topologically associating domain (TAD); the LRFN5 locus. An association between locus structural changes and developmental ...

• Metric based virtual simulation training for endovascular thrombectomy improves interventional neuroradiologists’ simulator performance 

  Schneider, Magnus Sundgot; Sandve, Knut Olav Lende; Kurz, Kathinka Dæhli; Dalen, Ingvild; Ospel, Johanna; Goyal, Mayank; Kurz, Friedrich Martin Wilhelm; Fjetland, Lars (Journal article; Peer reviewed, 2022)

  Objective Metric based virtual reality simulation training may enhance the capability of interventional neuroradiologists (INR) to perform endovascular thrombectomy. As pilot for a national simulation study we examined ...

• Seven-year trajectories of body weight, quality of life and comorbidities following Roux-en-Y gastric bypass and sleeve gastrectomy 

  Nielsen, Hans Jørgen; Nedrebø, Bjørn Gunnar; Fosså, Alexander; Andersen, John Roger; Assmus, Jörg; Dagsland, Vigdis Halvorsen; Dankel, Simon N; Gudbrandsen, Oddrun Anita; Fernø, Johan; Hjellestad, Iren Drange; Hjermstad, Marianne Jensen; Kolotkin, Ronette Loganzo; Thorsen, Håvard Luong; Mellgren, Gunnar; Flølo, Tone Nygaard (Journal article; Peer reviewed, 2022)

  Background/objectives There is limited long-term data comparing the outcomes of sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) for severe obesity, both with respect to body weight, quality of life (QOL) and ...

• Identification of microRNAs from medicinal plant Murraya Koenigii by high-throughput sequencing and their functional implications in secondary metabolite biosynthesis 

  Gutiérrez-García, Claudia; Ahmed, Shiek S. S. J.; Ramalingam, Sathishkumar; Selvaraj, Dhivya; Srivastava, Aashish; Paul, Sujay; Sharma, Ashutosh (Journal article; Peer reviewed, 2022)

  MicroRNAs (miRNAs) are small noncoding RNA molecules that play crucial post-transcriptional regulatory roles in plants, including development and stress-response signaling. However, information about their involvement in ...

• Placental weight centiles adjusted for age, parity and fetal sex 

  Flatley, Christopher; Sole-Navais, Pol; Vaudel, Marc; Helgeland, Øyvind; Modzelewska, Dominika; Johansson, Stefan; Jacobsson, Bo; Njølstad, Pål Rasmus (Journal article; Peer reviewed, 2022)

  Introduction The weight of the placenta can be indicative of efficacy in nutrient and oxygen supply. Furthermore, it has been suggested that a measure of the placenta's ability to adequately supply nutrients to the fetus ...

• Changes in eicosapentaenoic acid and docosahexaenoic acid and risk of cardiovascular events and atrial fibrillation: A secondary analysis of the OMEMI trial 

  Myhre, Peder Langeland; Kalstad, Are; Tveit, Sjur Hansen; Laake, Kristian; Schmidt, Erik B.; Smith, Pål; Nilsen, Dennis W.T.; Tveit, Arnljot; Solheim, Svein; Arnesen, Harald; Seljeflot, Ingebjørg (Journal article; Peer reviewed, 2022)

  Background The cardiovascular benefit from n-3 polyunsaturated fatty acids (PUFAs) after acute myocardial infarction (AMI) is controversial, and the importance of serum eicosapentaenoic acid (EPA) and docosahexaenoic acid ...

• Association of Excessive Sleepiness, Pathological Fatigue, Depression, and Anxiety With Different Severity Levels of Obstructive Sleep Apnea 

  Mjelle, Karin Elisabeth Sundt; Lehmann, Sverre; Saxvig, Ingvild W.; Gulati, Shashi; Bjorvatn, Bjørn (Journal article; Peer reviewed, 2022-03-31)

  Objective: The aim of this study was to investigate possible associations between obstructive sleep apnea and fatigue. This naturally led to considering the association between OSA and excessive sleepiness, depression, and ...

• Basosquamous Basal Cell Carcinoma with Bone Marrow Metastasis 

  Thunestvedt, Lise Mayrin Økland; Helgeland, Lars; Bachmann, Ingeborg Margrethe; Karlsdottir, Åsa; Haslerud, Torjan Magne; Reikvam, Håkon (Journal article; Peer reviewed, 2022-03-23)

  Basal cell carcinoma (BCC) is the most common cancer in Caucasians. It is slow growing and rarely metastasizes. If left untreated over time, invasive growth can occur. We present a patient case with a primary BCC located ...

• Lifelong exposure to residential greenspace and the premenstrual syndrome: A population-based study of Northern European women 

  Triebner, Kai Philipp; Markevych, Iana; Bertelsen, Randi Jacobsen; Skottvoll, Bente Sved; Hustad, Simon Steinar; Forsberg, Bertil; Franklin, Karl A; Holm, Mathias; Lindberg, Eva; Heinrich, Joachim; Real, Francisco Gomez; Dadvand, Payam (Journal article; Peer reviewed, 2022)

  Background: The premenstrual syndrome (PMS) causes clinically relevant psychological and physical symptoms in up to 20% of women of reproductive age. To date, no studies have investigated the relationship between PMS and ...

• New Evidence About Aortic Valve Stenosis and Cardiovascular Hemodynamics 

  Mancusi, Costantino; Bahlmann, Edda; Basile, Christian; Gerdts, Eva (Journal article; Peer reviewed, 2022)

  Aortic stenosis (AS) is the most common degenerative valvular disease in western word. In patients with severe AS, small changes in aortic valve area can lead to large changes in hemodynamics. The correct understanding of ...

• Metformin exposure, maternal PCOS status and fetal venous liver circulation: A randomized, placebo-controlled study 

  Grindheim, Sindre; Ebbing, Cathrine; Karlsen, Henriette Odland; Skulstad, Svein Magne; Real, Francisco Gomez; Lønnebotn, Marianne; Løvvik, Tone Shetelig; Vanky, Eszter; Kessler, Jørg (Journal article; Peer reviewed, 2022-01-28)

  Background: Metformin is prescribed to women with polycystic ovary syndrome (PCOS) to prevent pregnancy complications. Children exposed to metformin vs. placebo in utero, have increased head circumference at birth and are ...

• Aiming towards evidence based interpretation of cardiac biomarkers in patients presenting with chest pain : The WESTCOR study 

  Tjora, Hilde Lunde (Doctoral thesis, 2022-08-23)

  Bakgrunn: Ca 10% av alle pasientar i akuttmottak blir innlagt med brystsmerter og spørsmål om akutt koronarsyndrom (AKS), men under ¼ av pasientane har AKS. Metode:WESTCOR studien er ein prospektiv observasjonsstudie som ...

• Interleukin-18 signaling system links to agitation in severe mental disorders 

  Hjell, Gabriela; Szabo, Attila; Mørch-Johnsen, Lynn Egeland; Holst, Rene; Tesli, Natalia; Bell, Christina; Fischer-Vieler, Thomas; Werner, Maren Caroline Frogner; Lunding, Synve Hoffart; Ormerod, Monica Bettina E. Greenwood; Johansen, Ingrid Torp; Dieset, Ingrid; Djurovic, Srdjan; Melle, Ingrid; Ueland, Thor; Andreassen, Ole; Steen, Nils Eiel; Haukvik, Unn Kristin Hansen (Journal article; Peer reviewed, 2022)

  Objective Agitation is a challenging clinical feature in severe mental disorders, but its biological correlates are largely unknown. Inflammasome-related abnormalities have been linked to severe mental disorders and ...

• Conundrums in the breathless athlete; exercise-induced laryngeal obstruction or asthma? 

  Jansrud, Ida; Halvorsen, Thomas; Vollsæter, Maria; Hilland, Magnus; Heimdal, John-Helge; Røksund, Ola Drange; Clemm, Hege Synnøve Havstad (Journal article; Peer reviewed, 2022)

  Purpose: Exercise-induced bronchoconstriction (EIB) and exercise-induced laryngeal obstruction (EILO) are the two disorders commonly considered when athletes complain of exertional dyspnea. They are highly different but ...

• Antibiotic use in children before, during and after hospitalisation 

  Thaulow, Christian Magnus; Blix, Hege Salvesen; Nilsen, Roy Miodini; Eriksen, Beate Horsberg; Wathne, Jannicke Slettli; Berild, Dag; Harthug, Stig (Journal article; Peer reviewed, 2022)

  Purpose To investigate ambulatory antibiotic use in children during 1 year before and 1 year after in-hospital antibiotic exposure compared to children from the general population that had not received antibiotics in-hospital. ...

• Left ventricular venting during extracorporeal membrane oxygenation; the effects on cardiac performance in a porcine model of critical post-cardiotomy failure 

  Solholm, Atle; Salminen, Pirjo-Riitta; Stangeland, Lodve; Dahle, Geir Olav; Mongstad, Arve; Svenheim, Bård; Zhang, Liqun; Haaverstad, Rune; Grong, Ketil (Journal article; Peer reviewed, 2022)

  Introduction Left ventricular distension is a major concern with postcardiotomy veno-arterial extracorporeal membrane oxygenation (VA-ECMO) supporting a critical heart failure after cardiac surgery. This porcine study ...

• Limited association between infections, autoimmune disease and genetic risk and immune activation in severe mental disorders 

  Werner, Maren Caroline Frogner; Wirgenes, Katrine Verena; Shadrin, Alexey; Lunding, Synve Hoffart; Rødevand, Linn; Hjell, Gabriela; Ormerod, Monica; Haram, Marit; Agartz, Ingrid; Djurovic, Srdjan; Melle, Ingrid; Aukrust, Pål; Ueland, Thor; Andreassen, Ole; Steen, Nils Eiel (Journal article; Peer reviewed, 2022)

  Background Low-grade inflammation may be part of the underlying mechanism of schizophrenia and bipolar disorder. We investigated if genetic susceptibility, infections or autoimmunity could explain the immune activation. ...

• The multidimensional fatigue inventory (MFI-20): psychometrical testing in a Norwegian sample of inflammatory bowel disease (IBD) patients 

  Jelsness-Jørgensen, Lars-Petter; Moum, Bjørn Allan; Grimstad, Tore Bjørn; Jahnsen, Jørgen; Hovde, Øistein; Frigstad, Svein Oskar; Bernklev, Tomm (Journal article; Peer reviewed, 2022)

  OBJECTIVES To evaluate the psychometric properties of the Norwegian version of the multidimensional fatigue inventory (MFI-20) in patients with inflammatory bowel disease. METHODS Participants were recruited from nine ...

• Characterization of the genetic architecture of infant and early childhood body mass index 

  Helgeland, Øyvind; Vaudel, Marc; Sole-Navais, Pol; Flatley, Christopher; Juodakis, Julius; Bacelis, Jonas; Koløen, Ingvild; Knudsen, Gun Peggy Strømstad; Johansson, Bente Berg; Magnus, Per Minor; Reichborn-Kjennerud, Ted; Juliusson, Pétur Benedikt; Stoltenberg, Camilla; Holmen, Oddgeir Lingaas; Andreassen, Ole; Jacobsson, Bo; Njølstad, Pål Rasmus; Johansson, Stefan (Journal article; Peer reviewed, 2022)

  Early childhood obesity is a growing global concern; however, the role of common genetic variation on infant and child weight development is unclear. Here, we identify 46 loci associated with early childhood body mass index ...

• Lifetime Cannabis Use Is Not Associated With Negative Beliefs About Medication in Patients With First Treatment Psychosis 

  Gjerde, Priyanthi Borgen; Steen, Synne Wollen; Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Reponen, Elina Johanna; Andreassen, Ole; Steen, Vidar Martin; Melle, Ingrid (Journal article; Peer reviewed, 2022)

  Objective: Cannabis use is common among patients with psychosis, and along with negative beliefs about medication, it has been found to predict poor adherence to antipsychotic drug treatment. Such lack of adherence to ...

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