• Laryngeal response to high-intensity exercise in healthy athletes 

  Carlsen, Petter Helø; Muralitharan, Praveen; Fenne, Hilde; Jansrud, Ida; Engan, Mette; Vollsæter, Maria; Bovim, Lars Peder Vatshelle; Røksund, Ola Drange; Halvorsen, Thomas; Clemm, Hege Synnøve Havstad (Journal article; Peer reviewed, 2024)

  Introduction Exercise-induced laryngeal obstruction (EILO) is a common cause of exertional breathing problems. The current diagnostic approach rests on evaluation of laryngeal obstruction visualised by laryngoscopy performed ...

• In Vitro Functional Analysis Can Aid Precision Diagnostics of HNF1B-MODY 

  Pavithram, Aishwarya; Zhang, Haichen; Maloney, Kristin A.; Ringdal, Monika; Kaci, Alba; Sagen, Jørn Vegard; Kleinberger, Jeffrey; Jeng, Linda J.B.; Njølstad, Pål Rasmus; Pollin, Toni I.; Molnes, Janne; Johansson, Bente Berg (Journal article; Peer reviewed, 2024)

  Precision medicine relies on accurate and consistent classification of sequence variants. A correct diagnosis of hepatocyte nuclear factor (HNF) 1B maturity-onset diabetes of the young, caused by pathogenic variants in the ...

• Influence of cardiorespiratory fitness on obesity-associated inflammation in women and men: The FATCOR study 

  Midtbø, Helga Bergljot; Ulvik, Arve; Cramariuc, Dana; Meyer, Klaus; Ueland, Per Magne; Halland, Hilde; Gerdts, Eva (Journal article; Peer reviewed, 2024)

  Background and aims Cardiorespiratory fitness has been postulated to lower chronic inflammation in obesity. We assessed sex-specific associations of inflammation with cardiorespiratory fitness in overweight and obese ...

• Glycolysis inhibition affects proliferation and cytotoxicity of Vγ9Vδ2 T cells expanded for adoptive cell therapy 

  Aehnlich, Pia; Santiago, Marta Velasco; Dam, Søren Helweg; Saló, Sara Fresnillo; Rahbech, Anne; Olsen, Lars Rønn; thor Straten, Per; Desler, Claus; Holmen Olofsson, Gitte (Journal article; Peer reviewed, 2024)

  Background aims Vγ9Vδ2 T cells are under investigation as alternative effector cells for adoptive cell therapy (ACT) in cancer. Despite promising in vitro results, anti-tumor efficacies in early clinical studies have been ...

• Rethinking High-Grade Serous Ovarian Carcinoma: Towards Personalized Immunotherapy through Preclinical, Translational and Clinical Evaluation of Combined CD73 and PD-L1 Blockade 

  Tandaric, Luka (Doctoral thesis, 2025-05-23)

  Bakgrunn: Selv om høygradig serøs eggstokkreft (HGSOC) klassifiseres som en immunogen krefttype med lovende prekliniske resultater, er effekten av immunterapi beskjeden. Økende grad av persontilpasning og biomarkør-basert ...

• European Society of Endocrinology and Endocrine Society Joint Clinical Guideline: Diagnosis and therapy of glucocorticoid-induced adrenal insufficiency 

  Beuschlein, Felix; Else, Tobias; Bancos, Irina; Hahner, Stefanie; Hamidi, Oksana; van Hulsteijn, Leonie; Husebye, Eystein Sverre; Karavitaki, Niki; Prete, Alessandro; Vaidya, Anand; Yedinak, Christine; Dekkers, Olaf M. (Journal article; Peer reviewed, 2024)

  Glucocorticoids are widely prescribed as anti-inflammatory and immunosuppressive agents. This results in at least 1% of the population using chronic glucocorticoid therapy, being at risk for glucocorticoid-induced adrenal ...

• European association of perinatal medicine (EAPM) position statement: Screening, diagnosis and management of congenital anomalies of the umbilical cord 

  Jauniaux, Eric; Ebbing, Cathrine; Oyelese, Yinka; Maymon, Rony; Prefumo, Federico; Bhide, Amar (Journal article; Peer reviewed, 2024)

  Congenital anomalies of the umbilical cord are associated with an increased risk of pregnancy and perinatal complications. Some anomalies of the cord have a higher prevalence than other fetal structural anomalies. The most ...

• The diagnostic accuracy of quality control rules 

  Åsberg, Arne; Bolann, Bjørn (Journal article; Peer reviewed, 2024)

  Internal quality control in clinical chemistry laboratories are based on analyzing samples of stable control materials among the patient samples. The control results are interpreted by using quality control rules that ...

• High-throughput, low-cost quantification of 11 therapeutic antibodies using caprylic acid precipitation and LC-MS/MS 

  Hallin, Erik Ingmar; Serkland, Trond Trætteberg; Bjånes, Tormod Karlsen; Skrede, Silje (Journal article; Peer reviewed, 2024)

  Background Therapeutic drug monitoring of treatment with therapeutic antibodies is hampered by the application of a wide range of different methods in the quantification of serum levels. LC-MS based methods could significantly ...

• Immune-monitoring of myelodysplastic neoplasms: Recommendations from the i4MDS consortium 

  Tentori, Cristina A.; Zhao, Lin P.; Tinterri, Benedetta; Strange, Kathryn E.; Zoldan, Katharina; Dimopoulos, Konstantinos; Feng, Xingmin; Riva, Elena; Lim, Benjamin; Simoni, Yannick; Murthy, Vidhya; Hayes, Madeline J.; Poloni, Antonella; Padron, Eric; Cardoso, Bruno A.; Cross, Michael; Winter, Susann; Santaolalla, Aida; Patel, Bhavisha A.; Groarke, Emma M.; Wiseman, Daniel H.; Jones, Katy; Jamieson, Lauren; Manogaran, Charles; Daver, Naval; Gallur, Laura; Ingram, Wendy; Ferrell, P. Brent; Sockel, Katja; Dulphy, Nicolas; Chapuis, Nicolas; Kubasch, Anne S.; Kittang, Astrid Marta Olsnes; Kulasekararaj, Austin; De Lavellade, Hugues; Kern, Wolfgang; Van Hemelrijck, Mieke; Bonnet, Dominique; Westers, Theresia M.; Freeman, Sylvie; Oelschlaegel, Uta; Valcarcel, David; Raddi, Marco G.; Grønbæk, Kirsten; Fontenay, Michaela; Loghavi, Sanam; Santini, Valeria; Almeida, Antonio M.; Irish, Jonathan M.; Sallman, David A.; Young, Neal S.; van de Loosdrecht, Arjan A.; Adès, Lionel; Della Porta, Matteo G.; Cargo, Catherine; Platzbecker, Uwe; Kordasti, Shahram (Journal article; Peer reviewed, 2024)

  Advancements in comprehending myelodysplastic neoplasms (MDS) have unfolded significantly in recent years, elucidating a myriad of cellular and molecular underpinnings integral to disease progression. While molecular ...

• Deciphering the role of FUS::DDIT3 expression and tumor microenvironment in myxoid liposarcoma development 

  Ranji, Parmida; Jonasson, Emma; Andersson, Lisa; Filges, Stefan; Luna Santamaría, Manuel; Vannas, Christoffer; Dolatabadi, Soheila; Gustafsson, Anna; Myklebost, Ola; Håkansson, Joakim; Fagman, Henrik; Landberg, Göran; Åman, Pierre; Ståhlberg, Anders (Journal article; Peer reviewed, 2024)

  Background Myxoid liposarcoma (MLS) displays a distinctive tumor microenvironment and is characterized by the FUS::DDIT3 fusion oncogene, however, the precise functional contributions of these two elements remain enigmatic ...

• Modulating Nitric Oxide: Implications for Cytotoxicity and Cytoprotection 

  Belenichev, Igor; Popazova, Olena; Bukhtiyarova, Nina; Savchenko, Dmytro; Oksenych, Valentyn; Kamyshnyi, Oleksandr (Journal article; Peer reviewed, 2024-04-23)

  Despite the significant progress in the fields of biology, physiology, molecular medicine, and pharmacology; the designation of the properties of nitrogen monoxide in the regulation of life-supporting functions of the ...

• Frequency of ERBB2-Low Expression in Endometrial Cancer 

  Krakstad, Camilla; Berg, Hege Fredriksen; Lindemann, Kristina Yvonne Kathe; Halle, Mari Kyllesø (Journal article; Peer reviewed, 2024)

  The epidermal growth factor receptor 2 (ERBB2, formerly HER2)–targeting antibody drug conjugates (vic-)trastuzumab duocarmazine and trastuzumab deruxtecan have recently been tested in endometrial cancer (EC), including ...

• Distinguishing vulnerability and resilience to posttraumatic stress disorder evaluating traumatic experiences, genetic risk and electronic health records 

  Løkhammer, Solveig Brunstad; Koller, Dora; Wendt, Frank R.; Choi, Karmel W.; He, Jun; Friligkou, Eleni; Overstreet, Cassie; Gelernter, Joel; Hellard, Stephanie Francoise Claire Le; Polimanti, Renato (Journal article; Peer reviewed, 2024)

  What distinguishes vulnerability and resilience to posttraumatic stress disorder (PTSD) remains unclear. Levering traumatic experiences reporting, genetic data, and electronic health records (EHR), we investigated and ...

• Exploring Leptospira interrogans FDAARGOS_203: Insights into AMR and Anti-Phage Defense 

  Petakh, Pavlo; Oksenych, Valentyn; Kamyshnyi, Oleksandr (Journal article; Peer reviewed, 2024-03-08)

  Leptospira, which are known to be important disease-causing agents transmitted between animals and humans, result in significant illness and, in some cases, significant death in human populations. This purpose of this study ...

• Combined Pharmacological Modulation of Translational and Transcriptional Activity Signaling Pathways as a Promising Therapeutic Approach in Children with Myocardial Changes 

  Kamenshchyk, Andrii; Belenichev, Igor; Oksenych, Valentyn; Kamyshnyi, Oleksandr (Journal article; Peer reviewed, 2024-04-13)

  Myocardial hypertrophy is the most common condition that accompanies heart development in children. Transcriptional gene expression regulating pathways play a critical role both in cardiac embryogenesis and in the pathogenesis ...

• A review and analysis of outcomes in randomized clinical trials of plasma transfusion in patients with bleeding or for the prevention of bleeding: The BEST collaborative study 

  Apelseth, Torunn Oveland; Raza, Sheharyar; Callum, Jeannie; Ipe, Tina; Blackwood, Bronagh; Akhtar, Adeel; Hess, John R.; Marks, Denese C.; Brown, Bethany; Delaney, Meghan; Wendel, Silvano; Stanworth, Simon J. (Journal article; Peer reviewed, 2024)

  Background: Previous systematic reviews have revealed an inconsistency of outcome definitions as a major barrier in providing evidence-based guidance for the use of plasma transfusion to prevent or treat bleeding. We ...

• Detection of delirium in older patients—A point prevalence study in surgical and non-surgical hospital wards 

  Instenes, Irene; Eide, Leslie S.P.; Amofah, Hege Andersen; Fålun, Nina Britt; Pettersen, Trond Røed; Ranhoff, Anette Hylen; Rudolph, James L.; Steihaug, Ole Martin; Wentzel-Larsen, Tore; Norekvål, Tone Merete (Journal article; Peer reviewed, 2024)

  Aims and Objectives: To (i) determine the prevalence of delirium and identify delirium subtypes in surgical and non-surgical patients aged ≥65 years, (ii) determine whether certain precipitating factors affect the prevalence ...

• Systematic analysis of RNA-binding proteins identifies targetable therapeutic vulnerabilities in osteosarcoma 

  Zhou, Yang; Ray, Partho Sarothi; Zhu, Jianguo; Stein, Frank; Rettel, Mandy; Sekaran, Thileepan; Sahadevan, Sudeep; Perez-Perri, Joel I.; Roth, Eva K.; Myklebost, Ola; Meza, Leonardo Zepeda; von Deimling, Andreas; Fu, Chuli; Brosig, Annika N.; Pedersen, Kjetil Boye; Nathrath, Michaela; Blattmann, Claudia; Lehner, Burkhard; Hentze, Matthias W.; Kulozik, Andreas E. (Journal article; Peer reviewed, 2024)

  Osteosarcoma is the most common primary malignant bone tumor with a strong tendency to metastasize, limiting the prognosis of affected patients. Genomic, epigenomic and transcriptomic analyses have demonstrated the exquisite ...

• Monosomy 7/del(7q) cause sensitivity to inhibitors of nicotinamide phosphoribosyltransferase in acute myeloid leukemia 

  Eldfors, Samuli; Saad, Joseph; Ikonen, Nemo; Malani, Disha; Vähä-Koskel, Markus; Gjertsen, Bjørn Tore; Kontro, Mika; Porkka, Kimmo; Heckman, Caroline A. (Journal article; Peer reviewed, 2024)

  Monosomy 7 and del(7q) (-7/-7q) are frequent chromosomal abnormalities detected in up to 10% of patients with acute myeloid leukemia (AML). Despite unfavorable treatment outcomes, no approved targeted therapies exist for ...

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