Department of Clinical Science
Recent Submissions
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Development of lung diffusion to adulthood following extremely preterm birth
(Journal article; Peer reviewed, 2022)Background: Gas exchange in extremely preterm (EP) infants must take place in fetal lungs. Childhood lung diffusing capacity of the lung for carbon monoxide (DLCO) is reduced; however, longitudinal development has not been ... -
Alveolar function following extremely preterm birth
(Doctoral thesis, 2022-12-16)Bakgrunn: Ekstremt prematur (EP) fødsel skjer før normal lungeutvikling er fullført, og forstyrrer vekst og differensiering av alveolene. Mindre areal og tykkere membraner i alveolene gjør at lungenes evne til å drive ... -
Brain plasticity after cognitive intervention in patients with mild cognitive impairment (MCI) evaluated by multimodal MR imaging in a randomized, controlled trial.
(Doctoral thesis, 2022-12-16)Hjerneplasitisitet undersøkt hos individer med mild kognitiv svikt etter PC-administrert arbeidsminnetrening, evaluert med multimodal MRI teknikk, en randomisert kontroll studie. Formål: Hovedmålet med studien var å ... -
Association of oral bacteria with oral hygiene habits and self-reported gingival bleeding
(Journal article; Peer reviewed, 2022)Aim To describe associations of gingival bacterial composition and diversity with self-reported gingival bleeding and oral hygiene habits in a Norwegian regional-based population. Materials and Methods We examined the ... -
VACCELERATE Volunteer Registry: A European study participant database to facilitate clinical trial enrolment
(Journal article; Peer reviewed, 2022)Introduction: The coronavirus disease 2019 (COVID-19) pandemic has evidenced the key role of vaccine design, obtention, production and administration to successfully fight against infectious diseases and to provide efficient ... -
Host Transcriptional Signatures Predict Etiology in Community-Acquired Pneumonia: Potential Antibiotic Stewardship Tools
(Journal article; Peer reviewed, 2022)Background: Current approaches for pathogen identification in community-acquired pneumonia (CAP) remain suboptimal, leaving most patients without a microbiological diagnosis. If better diagnostic tools were available for ... -
Differences in lung function, bronchial hyperresponsiveness and respiratory health between elite athletes competing in different sports
(Journal article; Peer reviewed, 2022)The aim of this study was to examine lung function, bronchial hyperresponsiveness (BHR) and exercise-induced respiratory symptoms in elite athletes performing different sports. Norwegian national-team athletes (30 swimmers, ... -
Shared genetic loci between depression and cardiometabolic traits
(Journal article; Peer reviewed, 2022-05-13)Epidemiological and clinical studies have found associations between depression and cardiovascular disease risk factors, and coronary artery disease patients with depression have worse prognosis. The genetic relationship ... -
Transcriptomic Profiling Reveals That HMGB1 Induces Macrophage Polarization Different from Classical M1
(Journal article; Peer reviewed, 2022-06-02)Macrophages are key inflammatory immune cells that display dynamic phenotypes and functions in response to their local microenvironment. In different conditions, macrophage polarization can be induced by high-mobility group ... -
Analysis of host-pathogen gene association networks reveals patient-specific response to streptococcal and polymicrobial necrotising soft tissue infections
(Journal article; Peer reviewed, 2022)Background: Necrotising soft tissue infections (NSTIs) are rapidly progressing bacterial infections usually caused by either several pathogens in unison (polymicrobial infections) or Streptococcus pyogenes (mono-microbial ... -
Radiation induced brain necrosis after proton therapy for head and neck cancer
(Doctoral thesis, 2022-12-09)Protonterapi gir reduksjon i normalvevsdoser sammenlignet med strålebehandling med fotoner, og det er antatt at dette vil resultere i en lavere forekomst av stråleinduserte seinskader. For å kompensere for en økt biologisk ... -
Neuronal Dysfunction Is Linked to the Famine-Associated Risk of Proliferative Retinopathy in Patients With Type 2 Diabetes
(Journal article; Peer reviewed, 2022-05-05)Persons with type 2 diabetes born in the regions of famine exposures have disproportionally elevated risk of vision-threatening proliferative diabetic retinopathy (PDR) in adulthood. However, the underlying mechanisms are ... -
Clonal evolution after treatment pressure in multiple myeloma: heterogenous genomic aberrations and transcriptomic convergence
(Journal article; Peer reviewed, 2022)We investigated genomic and transcriptomic changes in paired tumor samples of 29 in-house multiple myeloma (MM) patients and 28 patients from the MMRF CoMMpass study before and after treatment. A change in clonal composition ... -
Auxilin is a novel susceptibility gene for congenital heart block which directly impacts fetal heart function
(Journal article; Peer reviewed, 2022)Objective: Neonatal lupus erythematosus (NLE) may develop after transplacental transfer of maternal autoantibodies with cardiac manifestations (congenital heart block, CHB) including atrioventricular block, atrial and ... -
Islet cell replacement and transplantation immunology in a mouse strain with inducible diabetes
(Journal article; Peer reviewed, 2022)Improved models of experimental diabetes are needed to develop cell therapies for diabetes. Here, we introduce the B6 RIP-DTR mouse, a model of experimental diabetes in fully immunocompetent animals. These inbred mice ... -
Prematur ovarialinsuffisiens
(Journal article; Peer reviewed, 2022)Prematur ovarialinsuffisiens defineres som tap av ovariefunksjon før 40 års alder og er en kompleks tilstand med heterogen etiologi. Tidlig diagnose og igangsetting av hormonerstattende behandling er viktig for å lindre ... -
MRI adipose tissue segmentation and quantification in R (RAdipoSeg)
(Journal article; Peer reviewed, 2022-10-08)Background: Excess adipose tissue is associated with increased cardiovascular and metabolic risk, but the volume of visceral and subcutaneous adipose tissue poses different metabolic risks. MRI with fat suppression can be ... -
Impact of rapid molecular testing on diagnosis, treatment and management of community-acquired pneumonia in Norway: a pragmatic randomised controlled trial (CAPNOR)
(Journal article; Peer reviewed, 2022)Background: Community-acquired pneumonia (CAP) causes a large burden of disease. Due to difficulties in obtaining representative respiratory samples and insensitive standard microbiological methods, the microbiological ... -
Health-related quality of life in patients with advanced melanoma treated with ipilimumab: prognostic implications and changes during treatment
(Journal article; Peer reviewed, 2022)Background: We have previously reported that the safety and efficacy of ipilimumab in real-world patients with metastatic melanoma were comparable to clinical trials. Few studies have explored health-related quality of ... -
Cohort profile: the Norwegian Registry of Persons Assessed for Cognitive Symptoms (NorCog) - a national research and quality registry with a biomaterial collection
(Journal article; Peer reviewed, 2022)Purpose: The Norwegian Registry of Persons Assessed for Cognitive Symptoms (NorCog) was established to harmonise and improve the quality of diagnostic practice across clinics assessing persons with cognitive symptoms in ...
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