Department of Clinical Science
Nye registreringer
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Healthcare professionals’ information need related to antiseizure medication use in breastfeeding patients with epilepsy. Retrospective analysis of enquiries to Norwegian medicines information and pharmacovigilance centers
(Journal article; Peer reviewed, 2023)Background: Safety information of antiseizure medication (ASM) during breastfeeding is scarce and conflicting. We aimed to identify characteristic traits of safety concerns among healthcare professionals by reviewing ... -
Demultiplexing Stress Responses and Compensatory Mechanisms in the Pancreatic Islet
(Doctoral thesis, 2024-06-21)Et nøkkelelement i utviklingen av diabetes er den manglende evnen hos de insulinproduserende β-cellene til å møte et stigende behov for insulin, skapt av dysfunksjonelle eller døde β-celler. Det er mange faktorer som ... -
Unveiling the Complexities: Patients’ and Healthcare Providers’ Perspectives on Understanding and Managing Ovarian Cancer
(Doctoral thesis, 2024-06-28)Bakgrunn: Eggstokkreft er en alvorlig og kompleks sykdom, som fremdeles har en dårlig prognose til tross for betydelige medisinske fremskritt, inkludert innen presisjonsonkologi. Pasienter med eggstokkreft gjennomgår et ... -
Shared Genetic Loci Between Schizophrenia and White Blood Cell Counts Suggest Genetically Determined Systemic Immune Abnormalities
(Journal article; Peer reviewed, 2023)Background: Immune mechanisms are indicated in schizophrenia (SCZ). Recent genome-wide association studies (GWAS) have identified genetic variants associated with SCZ and immune-related phenotypes. Here, we use cutting ... -
The relationship between workload and exercise-induced cardiac troponin elevations is influenced by non-obstructive coronary atherosclerosis
(Journal article; Peer reviewed, 2024)The relationship between exercise-induced troponin elevation and non-obstructive coronary artery disease (CAD) is unclear. This observational study assessed non-obstructive CAD's impact on exercise-induced cardiac Troponin ... -
The first vanE-type vancomycin resistant Enterococcus faecalis isolates in Norway – phenotypic and molecular characteristics
(Journal article; Peer reviewed, 2023)Objectives We aimed to characterize the vanE cluster and its genetic support in the first Norwegian vanE-type isolates and assess genetic relatedness to other vanE isolates. Methods Two vanE-type vancomycin resistant ... -
The relationship between exercise-induced cardiac Troponin increase and physical workload during prolonged strenuous exercise : North Sea Endurance Exercise Study (NEEDED) 2018
(Doctoral thesis, 2024-06-06)Bakgrunn Høye nivåer av kardial troponin (cTn) er knyttet til økt dødelighet og en høyere sjanse for udiagnostisert koronararteriesykdom (CAD). Denne avhandlingen hadde som mål å undersøke sammenhengen mellom treningsintensitet ... -
Extending protein interaction networks using proteoforms and small molecules
(Journal article; Peer reviewed, 2023)Motivation: Biological network analysis for high-throughput biomedical data interpretation relies heavily on topological characteristics. Networks are commonly composed of nodes representing genes or proteins that are ... -
Variation in antibiotic consumption in very preterm infants-a 10 year population-based study
(Journal article; Peer reviewed, 2023)Objectives Wide variations in antibiotic use in very preterm infants have been reported across centres despite similar rates of infection. We describe 10 year trends in use of antibiotics and regional variations among ... -
Machine learning approaches in microbiome research: challenges and best practices
(Journal article; Peer reviewed, 2023)Microbiome data predictive analysis within a machine learning (ML) workflow presents numerous domain-specific challenges involving preprocessing, feature selection, predictive modeling, performance estimation, model ... -
Phase II study of everolimus and temozolomide as first-line treatment in metastatic high-grade gastroenteropancreatic neuroendocrine neoplasms
(Journal article; Peer reviewed, 2023)Background The optimal treatment for metastatic high-grade gastroenteropancreatic (GEP) neuroendocrine neoplasms when Ki-67 ≤55% is unknown. A prospective multi-centre phase 2 study was performed to evaluate the efficacy ... -
Prolonging the delivery of influenza virus vaccine improves the quantity and quality of the induced immune responses in mice
(Journal article; Peer reviewed, 2023)Introduction: Influenza vaccines play a vital role in protecting individuals from influenza virus infection and severe illness. However, current influenza vaccines have suboptimal efficacy, which is further reduced in cases ... -
Impaired glucose tolerance and cardiovascular risk factors in relation to infertility: a Mendelian randomization analysis in the Norwegian Mother, Father, and Child Cohort Study
(Journal article; Peer reviewed, 2024)Study question: Are impaired glucose tolerance (as measured by fasting glucose, glycated hemoglobin, and fasting insulin) and cardiovascular disease risk (as measured by low-density lipoprotein cholesterol, high-density ... -
Distinct HLA associations with autoantibody-defined subgroups in idiopathic inflammatory myopathies
(Journal article; Peer reviewed, 2023)Background In patients with idiopathic inflammatory myopathies (IIM), autoantibodies are associated with specific clinical phenotypes suggesting a pathogenic role of adaptive immunity. We explored if autoantibody profiles ... -
Is the fetus fit for labor? Introducing fast-and-frugal trees (FFTrees) to simplify triage of women for STAN monitoring: An interobserver agreement comparison with traditional classification
(Journal article; Peer reviewed, 2023)Introduction It is a shortcoming of traditional cardiotocography (CTG) classification table formats that CTG traces are frequently classified differently by different users, resulting in poor interobserver agreements. ... -
Altered biomarkers for cardiovascular disease and inflammation in autoimmune Addison's disease - a cross-sectional study
(Journal article; Peer reviewed, 2023)Objective: Increased prevalence of cardiovascular disease has been reported in autoimmune Addison's disease (AAD), but pathomechanisms are poorly understood. Design: Cross-sectional study. Methods: We compared serum ... -
Do differences in diagnostic criteria for late fetal growth restriction matter?
(Journal article; Peer reviewed, 2023)BACKGROUND Criteria for diagnosis of fetal growth restriction differ widely according to national and international guidelines, and further heterogeneity arises from the use of different biometric and Doppler reference ... -
Reduced lung function and cause-specific mortality: A population-based study of Norwegian men followed for 26 years
(Journal article; Peer reviewed, 2023)Background and aim Reduced lung function is associated with increased mortality, but it is unclear how different spirometric patterns are related to specific deaths. Aim of this study was to investigate these associations ... -
Low levels of endogenous anabolic androgenic steroids in females with severe asthma taking corticosteroids
(Journal article; Peer reviewed, 2023)Rationale Patients with severe asthma are dependent upon treatment with high doses of inhaled corticosteroids (ICS) and often also oral corticosteroids (OCS). The extent of endogenous androgenic anabolic steroid (EAAS) ... -
Relation between HLA and copy number variation of steroid 21-hydroxylase in a Swedish cohort of patients with autoimmune Addison’s disease
(Journal article; Peer reviewed, 2023)Objective Autoantibodies against the adrenal enzyme 21-hydroxylase is a hallmark manifestation in autoimmune Addison's disease (AAD). Steroid 21-hydroxylase is encoded by CYP21A2, which is located in the human leucocyte ...