• Graphene-based phenformin carriers for cancer cell treatment: a comparative study between oxidized and pegylated pristine graphene in human cells and zebrafish 

  Alhourani, Abdelnour; Førde, Jan-Lukas; Nasrollahzadeh, Mojdeh; Eichacker, Lutz Andreas; Herfindal, Lars; Hagland, Hanne Røland (Journal article; Peer reviewed, 2022)

  Graphene is an attractive choice for the development of an effective drug carrier in cancer treatment due to its high adsorption area and pH-responsive drug affinity. In combination with the highly potent metabolic drug ...

• Clinical impact of changes in mitral regurgitation severity after medical therapy optimization in heart failure 

  Pagnesi, Matteo; Adamo, Marianna; Sama, Iziah E.; Anker, Stefan D.; Cleland, John G.; Dickstein, Kenneth; Filippatos, Gerasimos S.; Inciardi, Riccardo M.; Lang, Chim C.; Lombardi, Carlo; Ng, Leong L.; Ponikowski, Piotr; Samani, Nilesh J.; Zannad, Faiez; van Veldhuisen, Dirk J.; Voors, Adriaan A.; Metra, Marco (Journal article; Peer reviewed, 2022)

  Background: Few data are available regarding changes in mitral regurgitation (MR) severity with guideline-recommended medical therapy (GRMT) in heart failure (HF). Our aim was to evaluate the evolution and impact of MR ...

• Clinical implications of low estimated protein intake in patients with heart failure 

  Streng, Koen W.; Hillege, Hans L.; ter Maaten, Jozine M.; van Veldhuisen, Dirk J.; Dickstein, Kenneth; Ng, Leong L.; Samani, Nilesh J.; Metra, Marco; Ponikowski, Piotr; Cleland, John G.; Anker, Stefan D.; Romaine, Simon P.R.; Damman, Kevin; van der Meer, Peter; Lang, Chim C.; Voors, Adriaan A. (Journal article; Peer reviewed, 2022)

  Background: A higher protein intake has been associated with a higher muscle mass and lower mortality rates in the general population, but data about protein intake and survival in patients with heart failure (HF) are ...

• Autoimmune Thyroid Disorders in Autoimmune Addison Disease 

  Stokland, Ann-Elin Meling; Ueland, Grethe Åstrøm; Lima, Kari; Grønning, Kaja; Finnes, Trine Elisabeth; Svendsen, Margrethe; Tomkowicz, Aneta Ewa; Holte, Synnøve Emblem; Sollid, Stina Therese; Debowska, Aleksandra; Singsås, Hallvard; Rensvik, Marthe Landsverk; Lejon, Helle; Sørmo, Dag-Erik; Svare, Anders; Blika, Sigrid; Milova, Petya; Korsgaard, Elin; Husby, Øystein; Breivik, Lars Ertesvåg; Jørgensen, Anders Palmstrøm; Husebye, Eystein Sverre (Journal article; Peer reviewed, 2022)

  Context: Autoimmune thyroid disease is the most common endocrine co-morbidity in autoimmune Addison's disease (AAD), but detailed investigations of prevalence and clinical course is lacking. Objective: Provide comprehensive ...

• Left vocal cord paralysis, lung function and exercise capacity in young adults born extremely preterm with a history of neonatal patent ductus arteriosus surgery—A national cohort study 

  Engan, Mette; Engeset, Merete Salveson; Sandvik, Lorentz; Gamlemshaug, Ole C.O.; Engesæter, Ingvild Øvstebø; Øymar, Knut Asbjørn Alexander; Vollsæter, Maria; Røksund, Ola Drange; Hufthammer, Karl Ove; Halvorsen, Thomas; Clemm, Hege Synnøve Havstad (Journal article; Peer reviewed, 2022-01-03)

  Background: Left vocal cord paralysis (LVCP) is a known complication of patent ductus arteriosus (PDA) surgery in extremely preterm (EP) born neonates; however, consequences of LVCP beyond the first year of life are ...

• Increased risk of atrial fibrillation among elderly Norwegian men with a history of long-term endurance sport practice 

  Myrstad, Marius; Løchen, Maja-Lisa; Graff-Iversen, Sidsel; Gulsvik, Anne Kristine; Thelle, Dag Steinar; Stigum, Hein; Ranhoff, Anette Hylen (Journal article; Peer reviewed, 2014)

  Atrial fibrillation (AF) is the most common cardiac arrhythmia. The prevalence increases with increasing age. In middle-aged men, endurance sport practice is associated with increased risk of AF but there are few studies ...

• Physical activity and exercise capacity in survivors of preterm birth : A population-based cohort study of long-term consequences of prematurity 

  Engan, Mette (Doctoral thesis, 2022-05-19)

  Background: Physical activity (PA) is an important mediator of health. Extremely preterm (EP) (<28 weeks’ gestation) and extremely low birth weight (ELBW) (<1000 g) subjects are at increased risk of long-term sequelae that ...

• Sperm counts and endocrinological markers of spermatogenesis in long-term survivors of testicular cancer 

  Brydøy, Marianne; Fosså, Sophie Dorothea; Klepp, Olbjørn; Bremnes, Roy M.; Wist, Erik; Bjøro, Trine; Wentzel-Larsen, Tore; Dahl, Olav (Journal article; Peer reviewed, 2012)

  Background: The objective of this study was to assess markers of spermatogenesis in long-term survivors of testicular cancer (TC) according to treatment, and to explore correlations between the markers and associations ...

• Vinorelbine and gemcitabine vs vinorelbine and carboplatin as first-line treatment of advanced NSCLC. A phase III randomised controlled trial by the Norwegian Lung Cancer Study Group 

  Fløtten, Øystein; Grønberg, Bjørn Henning; Bremnes, Roy M.; Amundsen, Tore; Sundstrøm, Stein Harald; Rolke, Heidi; Hornslien, Kjersti; Wentzel-Larsen, Tore; Aasebø, Ulf; von Plessen, Christian (Journal article; Peer reviewed, 2012)

  Background: Platinum-based doublet chemotherapy is the standard first-line treatment for advanced non-small cell lung cancer (NSCLC), but earlier studies have suggested that non-platinum combinations are equally effective ...

• Modeling assortative mating and genetic similarities between partners, siblings, and in-laws 

  Torvik, Fartein Ask; Eilertsen, Espen Moen; Hannigan, Laurie J.; Cheesman, Rosa; Howe, Laurence J.; Magnus, Per Minor; Reichborn-Kjennerud, Ted; Andreassen, Ole A.; Njølstad, Pål Rasmus; Havdahl, Alexandra; Ystrøm, Eivind (Journal article; Peer reviewed, 2022)

  Assortative mating on heritable traits can have implications for the genetic resemblance between siblings and in-laws in succeeding generations. We studied polygenic scores and phenotypic data from pairs of partners ...

• A nationwide school fruit and vegetable policy and childhood and adolescent overweight: A quasi-natural experimental study 

  Øvrebø, Bente; Stea, Tonje Holte; Bergh, Ingunn Holden; Bere, Elling Tufte; Suren, Pål; Magnus, Per Minor; Juliusson, Pétur Benedikt; Wills, Andrew Keith (Journal article; Peer reviewed, 2022)

  Background School free fruit and vegetable (FFV) policies are used to promote healthy dietary habits and tackle obesity; however, our understanding of their effects on weight outcomes is limited. We assess the effect of ...

• Hva består oksymetriparametrene på blodgassutskriften av? 

  Vinnes, Erik Wilhelm; Holmaas, Gunhild (Journal article, 2022)

• Oral health-related interdisciplinary practices among healthcare professionals in Saudi Arabia: Does integrated care exist? 

  Gaffar, Balgis; Farooqi, Faraz Ahmed; Nazir, Muhammad Ashraf; Bakhurji, Eman; Al-Khalifa, Khalifa S.; Alhareky, Muhanad; Virtanen, Jorma (Journal article; Peer reviewed, 2022)

  Background There is a bidirectional relation between oral and general health, therefore collaboration between healthcare providers is needed. This study investigated current interdisciplinary practices (IDP) and the ...

• Early life growth and associations with lung function and bronchial hyperresponsiveness at 11-years of age 

  Mikalsen, Ingvild Bruun; Halvorsen, Thomas; Juliusson, Pétur Benedikt; Magnus, Maria Christine; Nystad, Wenche; Stensrud, Trine; Størdal, Ketil; Vollsæter, Maria; Øymar, Knut Asbjørn Alexander (Journal article; Peer reviewed, 2021)

  Low birthweight and being born small-for-gestational age (SGA) are linked to asthma and impaired lung function. Particularly, poor intrauterine growth followed by rapid catch-up growth during childhood may predispose for ...

• Major increase in microbiota-dependent proatherogenic metabolite TMAO one year after bariatric surgery 

  Trøseid, Marius; Hov, Johannes Espolin Roksund; Nestvold, Torunn Kristin; Thoresen, Hanne; Berge, Rolf Kristian; Svardal, Asbjørn M.; Lappegård, Knut Tore (Journal article; Peer reviewed, 2016)

  Background: Trimethylamine-N-oxide (TMAO) is formed in the liver from trimethylamine (TMA), a product exclusively generated by the gut microbiota from dietary phosphatidylcholine and carnitine. An alternative pathway of ...

• Genetics of vestibular schwannoma : Genetic landscape of irradiated and radiation-naïve benign and malignant vestibular schwannoma 

  Håvik, Aril Løge (Doctoral thesis, 2022-05-06)

  Background: Vestibular schwannoma (VS) is a benign intracranial neoplasm associated with reduced quality of life. Malignant peripheral nerve sheath tumor of the vestibular nerve (VN-MPNST) is the malignant counterpart, an ...

• Presence of interferon-λ 4, male gender, absent/mild steatosis and low viral load augment antibody levels to hepatitis C virus 

  Waldenström, Jesper; Hellstrand, Kristoffer; Westin, Johan; Nilsson, Staffan; Christensen, Peer; Färkkilä, Martti; Mørch, Kristine; Langeland, Nina; Norkrans, Gunnar; Lagging, Martin (Journal article; Peer reviewed, 2021)

  Objectives Despite recombinant interferon-λ 4 (IFN-λ4) demonstrating anti-viral activity in vitro and the ancestral functional gene (IFNL4) being conserved in all other primates, there has been speculation that IFN-λ4 may ...

• The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function 

  Oftedal, Bergithe Eikeland; Maio, Stefano; Handel E, Adam; White PJ, Madeleine; Howie, Duncan; Davis, Simon; Prevot, Nicolas; Rota A, Ioanna; Deadman E, Mary; Kessler M, Benedict; Fischer, Roman; Trede S, Nikolaus; Sezgin, Erdinc; Maizels M, Rick; Holländer, Georg A. (Journal article; Peer reviewed, 2021)

  T cells rely for their development and function on the correct folding and turnover of proteins generated in response to a broad range of molecular cues. In the absence of the eukaryotic type II chaperonin complex, CCT, T ...

• Cancer Predisposition Sequencing Reporter (CPSR): A flexible variant report engine for high-throughput germline screening in cancer 

  Nakken, Sigve; Saveliev, Vladislav; Hofmann, Oliver; Møller, Pål; Myklebost, Ola; Hovig, Eivind (Journal article; Peer reviewed, 2021)

  The value of high-throughput germline genetic testing is increasingly recognized inclinical cancer care. Disease-associated germline variants in cancer patients areimportant for risk management and surveillance, surgical ...

• Hypertension in women: Should there be a sex-specific threshold? 

  Gerdts, Eva; de Simone, Giovanni (Journal article; Peer reviewed, 2021)

  Conventionally, hypertension is defined by the same blood pressure (BP) threshold (systolic BP ≥140 and/or diastolic BP ≥90 mmHg) in both women and men. Several studies have documented that women with hypertension are more ...

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