Department of Clinical Science
Recent Submissions
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A cell competition-based small molecule screen identifies a novel compound that induces dual c-Myc depletion and p53 activation
(Journal article; Peer reviewed, 2021)Breakpoint Cluster Region-Abelson kinase (BCR–Abl) is a driver oncogene that causes chronic myeloid leukemia and a subset of acute lymphoid leukemias. Although tyrosine kinase inhibitors provide an effective treatment for ... -
Role of the Neutral Amino Acid Transporter SLC7A10 in Adipocyte Lipid Storage, Obesity and Insulin Resistance
(Journal article; Peer reviewed, 2021)Elucidation of mechanisms that govern lipid storage, oxidative stress, and insulin resistance may lead to improved therapeutic options for type 2 diabetes and other obesity-related diseases. Here, we find that adipose ... -
Population prevalence and inheritance pattern of recurrent CNVs associated with neurodevelopmental disorders in 12,252 newborns and their parents
(Journal article; Peer reviewed, 2020)Recurrent copy number variations (CNVs) are common causes of neurodevelopmental disorders (NDDs) and associated with a range of psychiatric traits. These CNVs occur at defined genomic regions that are particularly prone ... -
Low fibre intake is associated with gut microbiota alterations in chronic heart failure
(Journal article; Peer reviewed, 2020)Aims Recent reports have suggested that patients with heart failure (HF) have an altered gut microbiota composition; however, associations with diet remain largely uninvestigated. We aimed to explore differences in the ... -
Neurofilament light is a biomarker of brain involvement in lupus and primary Sjögren’s syndrome
(Journal article; Peer reviewed, 2020)Background To test the hypothesis that neurofilament light (NfL) in CSF is a biomarker of CNS involvement in patients with systemic lupus erythematosus (SLE) and primary Sjögren’s syndrome (pSS), we measured NfL in CSF ... -
Perfluoroalkyl substances (PFASs) and mercury in never-pregnant women of fertile age: association with fish consumption and unfavorable lipid profile
(Journal article; Peer reviewed, 2020)Objectives To examine concentrations of perfluoroalkyl substances (PFASs) and lifestyle factors that may contribute to higher levels of pollutants in never-pregnant women of fertile age. Design Observational ... -
The genetic architecture of the human cerebral cortex
(Journal article; Peer reviewed, 2020)INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities. Variations in human cortical surface area and thickness are associated with neurological, psychological, and behavioral traits and can be ... -
Live-attenuated influenza vaccine induces tonsillar follicular T helper cell responses that correlate with antibody induction
(Journal article; Peer reviewed, 2020)Background Influenza remains a major threat to public health. Live-attenuated influenza vaccines (LAIV) have been shown to be effective, particularly in children. Follicular T helper (TFH) cells provide B-cell help and ... -
The pulmonary mycobiome—A study of subjects with and without chronic obstructive pulmonary disease
(Journal article; Peer reviewed, 2021-04-07)Background: The fungal part of the pulmonary microbiome (mycobiome) is understudied. We report the composition of the oral and pulmonary mycobiome in participants with COPD compared to controls in a large-scale single-centre ... -
Preclinical molecular imaging in oncology – From chemical synthesis to clinical translatable applications
(Doctoral thesis, 2021-06-25)Background: Molecular imaging (MI) is fundamental in clinical settings for diagnosis, treatment selection, intraoperative guidance and treatment efficacy evaluation. This field has progressed rapidly in recent years, driven ... -
The mycobiome in COPD: Descriptive and longitudinal analysis, and participation in research bronchoscopy studies
(Doctoral thesis, 2021-06-25)Background: Chronic obstructive pulmonary disease (COPD) is a high-prevalent lung disease with high mortality rates. The COPD pathogenesis is only partly understood, and we do not know why some risk factor exposed subjects ... -
Improving response to progestin treatment of low-grade endometrial cancer
(Journal article; Peer reviewed, 2020)Objectives This review examines how response rates to progestin treatment of low-grade endometrial cancer can be improved. In addition to providing a brief overview of the pathogenesis of low-grade endometrial cancer, ... -
Reduced delays in diagnostic pathways for non-small cell lung cancer after local and National initiatives
(Journal article; Peer reviewed, 2020)Objectives Patients with non-small cell lung cancer (NSCLC) may experience progression and stage shift due to delays in a complex and time-consuming diagnostic work-up. We have analyzed the impact of both a local and ... -
Ancestrally Duplicated Conserved Noncoding Element Suggests Dual Regulatory Roles of HOTAIR in cis and trans
(Journal article; Peer reviewed, 2020-04)HOTAIR was proposed to regulate either HoxD cluster genes in trans or HoxC cluster genes in cis, a mechanism that remains unclear. We have identified a 32-nucleotide conserved noncoding element (CNE) as HOTAIR ancient ... -
Accurate 3-gene-signature for early diagnosis of liposarcoma progression
(Journal article; Peer reviewed, 2020)Background Well- and dedifferentiated liposarcoma (WD/DDLPS) are rare mesenchymal malignant tumors that account for 20% of all sarcomas in adults. The WD form is a low-grade malignancy with a favourable prognosis which ... -
Molecular characterization of a large unselected cohort of metastatic colorectal cancers in relation to primary tumor location, rare metastatic sites and prognosis
(Journal article; Peer reviewed, 2020-01-10)Background: We have reported that BRAF V600E mutations and microsatellite instability-high (MSI-H) are more prevalent in a population-based cohort of metastatic colorectal cancer (mCRC) patients than has been reported from ... -
The kynurenine pathway in cognition, dementia, and aging
(Doctoral thesis, 2021-06-16)Background: Experimental studies implicate the kynurenine pathway in cognitive function, dementia, aging, and longevity. Comparatively, clinical studies are few and most lack comprehensive targeted metabolomic profiling ... -
Second-line and Third-line therapy for Autoimmune Hepatitis: A position statement from the European Reference Network on Hepatological Diseases and the International Autoimmune Hepatitis Group
(Journal article; Peer reviewed, 2020)Most patients with autoimmune hepatitis respond well to standard immunosuppressive therapy with steroids and azathioprine, and while untreated disease is usually fatal, patients who respond well to therapy have an excellent ... -
Detection of remaining Plasmodium DNA and gametocytes during follow up after curative malaria treatment among returned travellers in Norway
(Journal article; Peer reviewed, 2020)Background PCR can be positive weeks after effective malaria treatment, potentially leading to over diagnose of recrudescence and re-infections. The DNA detected by PCR post-treatment might stem from residuals of destroyed ... -
Circulating trimethyllysine and risk of acute myocardial infarction in patients with suspected stable coronary heart disease
(Journal article; Peer reviewed, 2020)Background The carnitine precursor trimethyllysine (TML) is associated with progression of atherosclerosis, possibly through a relationship with trimethylamine-N-oxide (TMAO). Riboflavin is a cofactor in TMAO synthesis. ...
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