• Metformin exposure, maternal PCOS status and fetal venous liver circulation: A randomized, placebo-controlled study 

  Grindheim, Sindre; Ebbing, Cathrine; Karlsen, Henriette Odland; Skulstad, Svein Magne; Real, Francisco Gomez; Lønnebotn, Marianne; Løvvik, Tone Shetelig; Vanky, Eszter; Kessler, Jørg (Journal article; Peer reviewed, 2022-01-28)

  Background: Metformin is prescribed to women with polycystic ovary syndrome (PCOS) to prevent pregnancy complications. Children exposed to metformin vs. placebo in utero, have increased head circumference at birth and are ...

• Association of Excessive Sleepiness, Pathological Fatigue, Depression, and Anxiety With Different Severity Levels of Obstructive Sleep Apnea 

  Mjelle, Karin Elisabeth Sundt; Lehmann, Sverre; Saxvig, Ingvild W.; Gulati, Shashi; Bjorvatn, Bjørn (Journal article; Peer reviewed, 2022-03-31)

  Objective: The aim of this study was to investigate possible associations between obstructive sleep apnea and fatigue. This naturally led to considering the association between OSA and excessive sleepiness, depression, and ...

• New Evidence About Aortic Valve Stenosis and Cardiovascular Hemodynamics 

  Mancusi, Costantino; Bahlmann, Edda; Basile, Christian; Gerdts, Eva (Journal article; Peer reviewed, 2022)

  Aortic stenosis (AS) is the most common degenerative valvular disease in western word. In patients with severe AS, small changes in aortic valve area can lead to large changes in hemodynamics. The correct understanding of ...

• Basosquamous Basal Cell Carcinoma with Bone Marrow Metastasis 

  Thunestvedt, Lise Mayrin Økland; Helgeland, Lars; Bachmann, Ingeborg Margrethe; Karlsdottir, Åsa; Haslerud, Torjan Magne; Reikvam, Håkon (Journal article; Peer reviewed, 2022-03-23)

  Basal cell carcinoma (BCC) is the most common cancer in Caucasians. It is slow growing and rarely metastasizes. If left untreated over time, invasive growth can occur. We present a patient case with a primary BCC located ...

• Lifelong exposure to residential greenspace and the premenstrual syndrome: A population-based study of Northern European women 

  Triebner, Kai Philipp; Markevych, Iana; Bertelsen, Randi Jacobsen; Skottvoll, Bente Sved; Hustad, Simon Steinar; Forsberg, Bertil; Franklin, Karl A; Holm, Mathias; Lindberg, Eva; Heinrich, Joachim; Real, Francisco Gomez; Dadvand, Payam (Journal article; Peer reviewed, 2022)

  Background: The premenstrual syndrome (PMS) causes clinically relevant psychological and physical symptoms in up to 20% of women of reproductive age. To date, no studies have investigated the relationship between PMS and ...

• Aiming towards evidence based interpretation of cardiac biomarkers in patients presenting with chest pain : The WESTCOR study 

  Tjora, Hilde Lunde (Doctoral thesis, 2022-08-23)

  Bakgrunn: Ca 10% av alle pasientar i akuttmottak blir innlagt med brystsmerter og spørsmål om akutt koronarsyndrom (AKS), men under ¼ av pasientane har AKS. Metode:WESTCOR studien er ein prospektiv observasjonsstudie som ...

• Interleukin-18 signaling system links to agitation in severe mental disorders 

  Hjell, Gabriela; Szabo, Attila; Mørch-Johnsen, Lynn Egeland; Holst, Rene; Tesli, Natalia; Bell, Christina; Fischer-Vieler, Thomas; Werner, Maren Caroline Frogner; Lunding, Synve Hoffart; Ormerod, Monica Bettina E. Greenwood; Johansen, Ingrid Torp; Dieset, Ingrid; Djurovic, Srdjan; Melle, Ingrid; Ueland, Thor; Andreassen, Ole; Steen, Nils Eiel; Haukvik, Unn Kristin Hansen (Journal article; Peer reviewed, 2022)

  Objective Agitation is a challenging clinical feature in severe mental disorders, but its biological correlates are largely unknown. Inflammasome-related abnormalities have been linked to severe mental disorders and ...

• Conundrums in the breathless athlete; exercise-induced laryngeal obstruction or asthma? 

  Jansrud, Ida; Halvorsen, Thomas; Vollsæter, Maria; Hilland, Magnus; Heimdal, John-Helge; Røksund, Ola Drange; Clemm, Hege Synnøve Havstad (Journal article; Peer reviewed, 2022)

  Purpose: Exercise-induced bronchoconstriction (EIB) and exercise-induced laryngeal obstruction (EILO) are the two disorders commonly considered when athletes complain of exertional dyspnea. They are highly different but ...

• Antibiotic use in children before, during and after hospitalisation 

  Thaulow, Christian Magnus; Blix, Hege Salvesen; Nilsen, Roy Miodini; Eriksen, Beate Horsberg; Wathne, Jannicke Slettli; Berild, Dag; Harthug, Stig (Journal article; Peer reviewed, 2022)

  Purpose To investigate ambulatory antibiotic use in children during 1 year before and 1 year after in-hospital antibiotic exposure compared to children from the general population that had not received antibiotics in-hospital. ...

• Left ventricular venting during extracorporeal membrane oxygenation; the effects on cardiac performance in a porcine model of critical post-cardiotomy failure 

  Solholm, Atle; Salminen, Pirjo-Riitta; Stangeland, Lodve; Dahle, Geir Olav; Mongstad, Arve; Svenheim, Bård; Zhang, Liqun; Haaverstad, Rune; Grong, Ketil (Journal article; Peer reviewed, 2022)

  Introduction Left ventricular distension is a major concern with postcardiotomy veno-arterial extracorporeal membrane oxygenation (VA-ECMO) supporting a critical heart failure after cardiac surgery. This porcine study ...

• Limited association between infections, autoimmune disease and genetic risk and immune activation in severe mental disorders 

  Werner, Maren Caroline Frogner; Wirgenes, Katrine Verena; Shadrin, Alexey; Lunding, Synve Hoffart; Rødevand, Linn; Hjell, Gabriela; Ormerod, Monica; Haram, Marit; Agartz, Ingrid; Djurovic, Srdjan; Melle, Ingrid; Aukrust, Pål; Ueland, Thor; Andreassen, Ole; Steen, Nils Eiel (Journal article; Peer reviewed, 2022)

  Background Low-grade inflammation may be part of the underlying mechanism of schizophrenia and bipolar disorder. We investigated if genetic susceptibility, infections or autoimmunity could explain the immune activation. ...

• The multidimensional fatigue inventory (MFI-20): psychometrical testing in a Norwegian sample of inflammatory bowel disease (IBD) patients 

  Jelsness-Jørgensen, Lars-Petter; Moum, Bjørn Allan; Grimstad, Tore Bjørn; Jahnsen, Jørgen; Hovde, Øistein; Frigstad, Svein Oskar; Bernklev, Tomm (Journal article; Peer reviewed, 2022)

  OBJECTIVES To evaluate the psychometric properties of the Norwegian version of the multidimensional fatigue inventory (MFI-20) in patients with inflammatory bowel disease. METHODS Participants were recruited from nine ...

• Characterization of the genetic architecture of infant and early childhood body mass index 

  Helgeland, Øyvind; Vaudel, Marc; Sole-Navais, Pol; Flatley, Christopher; Juodakis, Julius; Bacelis, Jonas; Koløen, Ingvild; Knudsen, Gun Peggy Strømstad; Johansson, Bente Berg; Magnus, Per Minor; Reichborn-Kjennerud, Ted; Juliusson, Pétur Benedikt; Stoltenberg, Camilla; Holmen, Oddgeir Lingaas; Andreassen, Ole; Jacobsson, Bo; Njølstad, Pål Rasmus; Johansson, Stefan (Journal article; Peer reviewed, 2022)

  Early childhood obesity is a growing global concern; however, the role of common genetic variation on infant and child weight development is unclear. Here, we identify 46 loci associated with early childhood body mass index ...

• Lifetime Cannabis Use Is Not Associated With Negative Beliefs About Medication in Patients With First Treatment Psychosis 

  Gjerde, Priyanthi Borgen; Steen, Synne Wollen; Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Reponen, Elina Johanna; Andreassen, Ole; Steen, Vidar Martin; Melle, Ingrid (Journal article; Peer reviewed, 2022)

  Objective: Cannabis use is common among patients with psychosis, and along with negative beliefs about medication, it has been found to predict poor adherence to antipsychotic drug treatment. Such lack of adherence to ...

• Investigating the human jejunal microbiota 

  Villmones, Heidi Cecilie; Svanevik, Marius; Ulvestad, Elling; Stenstad, Tore; Anthonisen, Inger Lill; Nygaard, Randi Monsen; Dyrhovden, Ruben; Kommedal, Øyvind (Journal article; Peer reviewed, 2022)

  Descriptions of the small intestinal microbiota are deficient and conflicting. We aimed to get a reliable description of the jejunal bacterial microbiota by investigating samples from two separate jejunal segments collected ...

• COVID-19 pandemic and mortality in nursing homes across USA and Europe up to October 2021 

  Aalto, Ulla L.; Pitkala, Kaisu H; Andersen-Ranberg, Karen; Bonin-Guillaume, Sylvie; Cruz-Jentoft, Alfonso J.; Eriksdotter, Maria; Gordon, Adam; Gosch, Markus; Holmerova, Iva; Kautiainen, Hannu; Kivipelto, Miia; Macijauskiene, Jurate; O’Neill, Desmond; Van Den Noortgate, Nele; Ranhoff, Anette Hylen; Schols, Jos M. G. A.; Singler, Katrin; Stankunas, Mindaugas; Ouslander, Joseph G. (Journal article; Peer reviewed, 2022)

  Purpose: We compared the prevalence of COVID-19 and related mortality in nursing homes (NHs) in 14 countries until October 2021. We explored the relationship between COVID-19 mortality in NHs with the average size of NHs ...

• Breastfed Infants With Spells, Tremor, or Irritability: Rule Out Vitamin B12 Deficiency 

  Ljungblad, Ulf Wike; Astrup, Henriette; Mørkrid, Lars; Hager, Helle Borgstrøm; Lindberg, Morten; Eklund, Erik A.; Monsen, Anne-Lise Bjørke; Rootwelt-Revheim, Terje; Tangeraas, Trine (Journal article; Peer reviewed, 2022)

  Background: In Norway, 5-10% of neonates and infants have biomarkers suggesting vitamin B12 deficiency from newborn screening tests and unselected clinical screening, respectively. Aims: The aims were to identify risk ...

• Do reduced numbers of plasmacytoid dendritic cells contribute to the aggressive clinical course of COVID-19 in chronic lymphocytic leukaemia? 

  Smith, Carl Inge Edvard; Zain, Rula; Österborg, Anders; Palma, Marzia; Buggert, Marcus; Bergman, Peter; Bryceson, Yenan (Journal article; Peer reviewed, 2022)

  Infections with SARS-CoV-2 have been unduly severe in patients with haematological malignancies, in particular in those with chronic lymphocytic leukaemia (CLL). Based on a series of observations, we propose that an ...

• Exercise related respiratory problems in the young—Is it exercise-induced bronchoconstriction or laryngeal obstruction? 

  Vollsæter, Maria; Stensrud, Trine; Maat, Robert; Halvorsen, Thomas; Røksund, Ola Drange; Sandnes, Astrid; Clemm, Hege Synnøve Havstad (Journal article; Peer reviewed, 2022)

  Complaints of breathlessness during heavy exercise is common in children and adolescents, and represent expressions of a subjective feeling that may be difficult to verify and to link with specific diagnoses through objective ...

• Exercise-induced Laryngeal Obstruction: Protocol for a Randomized Controlled Treatment Trial 

  Clemm, Hege Synnøve Havstad; Røksund, Ola Drange; Andersen, Tiina Maarit; Heimdal, John-Helge; Karlsen, Tom; Hilland, Magnus; Fretheim-Kelly, Zoe; Hufthammer, Karl Ove; Sandnes, Astrid; Hjelle, Sigrun Margrethe; Vollsæter, Maria; Halvorsen, Thomas (Journal article; Peer reviewed, 2022)

  Background: Exercise-induced laryngeal obstruction (EILO) is a common cause of exertional breathing problems in young individuals, caused by paradoxical inspiratory adduction of laryngeal structures, and diagnosed by ...

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