• Novel biomarkers in patients with uncontrolled hypertension with and without kidney damage 

  Brobak, Karl Marius; Halvorsen, Lene Vernås; Aass, Hans Christian; Søraas, Camilla Lund; Aune, Arleen; Olsen, Erik; Bergland, Ola Undrum; Rognstad, Stine; Blom, Kjersti Benedicte; Birkeland, Jon Arne; Høieggen, Aud; Larstorp, Anne Cecilie Kjeldsen; Solbu, Marit Dahl (Journal article; Peer reviewed, 2024)

  Introduction Estimated glomerular filtration rate (eGFR) and urine albumin/creatinine ratio (ACR) are insensitive biomarkers for early detection of hypertension-mediated organ damage (HMOD). In this nationwide cross-sectional ...

• Reference intervals of circulating secretoneurin concentrations determined in a large cohort of community dwellers: the HUNT study 

  Aakre, Kristin Moberg; Lyngbakken, Magnus Nakrem; Faaren, Arne L.; Røsjø, Helge Rørvik; Dalen, Håvard; Omland, Torbjørn (Journal article; Peer reviewed, 2024)

  Objectives Secretoneurin (SN) is a novel cardiac biomarker that associates with the risk of mortality and dysfunctional cardiomyocyte Ca2+ handling in heart failure patients. Reference intervals for SN are unknown. M ...

• Clinicopathological and radiological stratification within FIGO 2018 stages improves risk-prediction in cervical cancer 

  Halle, Mari Kyllesø; Bozickovic, Olivera; Forsse, David Erik; Wagner-Larsen, Kari Strøno; Gold, Rose Meng; Lura, Njål; Woie, Kathrine; Bertelsen, Bjørn; Haldorsen, Ingfrid S.; Krakstad, Camilla (Journal article; Peer reviewed, 2024)

  Objective: Assess the added prognostic value of the updated International Federation of Gynecology and Obstetrics (FIGO) 2018 staging system, and to identify clinicopathological and radiological biomarkers for improved ...

• Lower Limits for Reporting High-Sensitivity Cardiac Troponin Assays and Impact of Analytical Performance on Patient Misclassification 

  Aakre, Kristin Moberg; Apple, Fred S.; Mills, Nicolas L.; Meex, Steven J.R.; Collinson, Paul O.; Hammarsten, Ola; Jaffe, Allan S.; Omland, Torbjørn; Sandoval, Yader; Cullen, Louise (Journal article; Peer reviewed, 2024)

  Background: Cardiac troponin measurements are indispensable for the diagnosis of myocardial infarction and provide useful information for long-term risk prediction of cardiovascular disease. Accelerated diagnostic pathways ...

• Areas of consensus on unwarranted and warranted transfers between nursing homes and emergency care facilities in Norway: a Delphi study 

  Wiik, Arne Bastian; Doupe, Malcolm Bray; Bakken, Marit Stordal; Kittang, Bård Reiakvam; Jacobsen, Frode F.; Førland, Oddvar (Journal article; Peer reviewed, 2024)

  Background Transferring residents from nursing homes (NHs) to emergency care facilities (ECFs) is often questioned as many are terminally ill and have access to onsite care. While some NH to ECF transfers have merit, ...

• Smoking during pregnancy and its effect on placental weight: a Mendelian randomization study 

  Jaitner, Annika; Vaudel, Marc; Tsaneva-Atanasova, Krasimira; Njølstad, Pål Rasmus; Jacobsson, Bo; Bowden, Jack; Johansson, Stefan; Freathy, Rachel M. (Journal article; Peer reviewed, 2024-04-04)

  Background: The causal relationship between maternal smoking in pregnancy and reduced offspring birth weight is well established and is likely due to impaired placental function. However, observational studies have given ...

• Three Scandinavian countries did not see the same increase in foetal situs inversus observed in China during the COVID-19 pandemic 

  Ludvigsson, Jonas F.; Håberg, Siri Eldevik; Juliusson, Pétur Benedikt; Andersen, Anne-Marie Nybo; Urhoj, Stine Kjaer; Stephansson, Olof (Journal article; Peer reviewed, 2024)

• Exercise training and high-sensitivity cardiac troponin-I in patients with heart failure with reduced ejection fraction 

  Riveland, Egil Aarstad; Valborgland, Torstein; Ushakova, Anastasia; Skadberg, Øyvind; Karlsen, Trine; Hole, Torstein Laurits; Støylen, Asbjørn; Dalen, Håvard; Videm, Vibeke; Koppen, Elias; Linke, Axel; Delagardelle, Charles; Van Craenenbroeck, Emeline M.; Beckers, Paul; Prescott, Eva; Halle, Martin; Omland, Torbjørn; Ellingsen, Øyvind; Larsen, Alf Inge (Journal article; Peer reviewed, 2024)

  Aims The aims of this sub-study of the SMARTEX trial were (1) to evaluate the effects of a 12-week exercise training programme on serum levels of high sensitivity cardiac troponin I (hs-cTnI) in patients with moderate ...

• A genome-wide association study provides insights into the genetic etiology of 57 essential and non-essential trace elements in humans 

  Moksnes, Marta Riise; Hansen, Ailin Falkmo; Wolford, Brooke; Thomas, Laurent Francois; Rasheed, Humaira; Simic, Anica; Bhatta, Laxmi; Brantsæter, Anne Lise; Surakka, Ida; Zhou, Wei; Magnus, Per Minor; Njølstad, Pål Rasmus; Andreassen, Ole; Syversen, Tore; Zheng, Jie; Fritsche, Lars; Evans, David M.; Warrington, Nicole Maree; Nøst, Therese Haugdahl; Åsvold, Bjørn Olav; Flaten, Trond Peder; Willer, Cristen J.; Hveem, Kristian; Brumpton, Ben Michael (Journal article; Peer reviewed, 2024)

  Trace elements are important for human health but may exert toxic or adverse effects. Mechanisms of uptake, distribution, metabolism, and excretion are partly under genetic control but have not yet been extensively mapped. ...

• Intake of different types of seafood and meat and risk of type 2 diabetes in women: a prospective study supported by a dietary intervention in mice 

  Myrmel, Lene Secher; Øyen, Jannike; Brantsæter, Anne Lise; Fjære, Even; Haugvaldstad, Karen; Birkeland, Kåre Inge; Nygård, Ottar Kjell; Kristiansen, Karstein Berge; Egeland, Grace M.; Madsen, Lise (Journal article; Peer reviewed, 2024)

  Detailed knowledge regarding the associations between intake of different types of seafood and meat and the risk of type 2 diabetes (T2D), and insight into possible mechanisms are warranted. In this study we aimed to ...

• No association between long-chain n-3 fatty acid intake during pregnancy and risk of type 1 diabetes in offspring in two large Scandinavian pregnancy cohorts 

  Lund-Blix, Nicolai Andre; Bjerregaard, Anne A.; Tapia, German; Størdal, Ketil; Brantsæter, Anne Lise; Strøm, Marin; Halldorsson, Thorhallur I.; Granstrøm, Charlotta; Svensson, Jannet; Joner, Geir; Skrivarhaug, Torild; Njølstad, Pål Rasmus; Olsen, Sjurdur F.; Stene, Lars Christian Mørch (Journal article; Peer reviewed, 2024)

  Aims/hypothesis The aim of this study was to investigate whether higher dietary intake of marine n-3 fatty acids during pregnancy is associated with a lower risk of type 1 diabetes in children. Methods The Danish ...

• Osteopontin characterizes bile duct-associated macrophages and correlates with liver fibrosis severity in primary sclerosing cholangitis 

  De Muynck, Kevin; Heyerick, Lander; De Ponti, Federico F.; Vanderborght, Bart; Meese, Tim; Van Campenhout, Sanne; Baudonck, Leen; Gijbels, Eva; Rodrigues, Pedro M.; Banales, Jesus M.; Vesterhus, Mette Nåmdal; Folseraas, Trine; Scott, Charlotte L.; Vinken, Mathieu; Van Der Linden, Malaïka; Hoorens, Anne; Van Dorpe, Jo; Lefere, Sander; Geerts, Anja; Van Nieuwerburgh, Filip; Verhelst, Xavier; Van Vlierberghe, Hans; Devisscher, Lindsey (Journal article; Peer reviewed, 2024)

  Background and Aims: Primary sclerosing cholangitis (PSC) is an immune-mediated cholestatic liver disease for which pharmacological treatment options are currently unavailable. PSC is strongly associated with colitis ...

• First trans-diagnostic experiences with a novel micro-choice based concentrated group rehabilitation for patients with low back pain, long COVID, and type 2 diabetes: a pilot study 

  Kvale, Gerd; Søfteland, Eirik; Jürgensen, Marte; Wilhelmsen-Langeland, Ane; Haugstvedt, Anne; Hystad, Sigurd William; Ødegaard-Olsen, Øystein Theodor; Aarli, Bernt Bøgvald; Rykken, Sidsel; Frisk, Bente (Journal article; Peer reviewed, 2024)

  Background The health care is likely to break down unless we are able to increase the level of functioning for the growing number of patients with complex, chronic illnesses. Hence, novel high-capacity and cost-effective ...

• Whole blood RNA sequencing identifies transcriptional differences between primary sclerosing cholangitis and ulcerative colitis 

  Wacker, Eike Matthias; Uellendahl-Werth, Florian; Bej, Saptarshi; Wolkenhauer, Olaf; Vesterhus, Mette Nåmdal; Lieb, Wolfgang; Franke, Andre; Karlsen, Tom Hemming; Folseraas, Trine; Ellinghaus, David (Journal article; Peer reviewed, 2024)

  Background & Aims: Genetic and microbiome studies across patients with primary sclerosing cholangitis (PSC) and ulcerative colitis (UC) have indicated that UC in PSC is a separate disease entity to primary UC, but expression ...

• Rough operators: sphingomyelinase inhibitors spike NK cells to kill cancer 

  Carlsten, Mattias; Bryceson, Yenan (Journal article; Peer reviewed, 2023)

• Endovascular treatment in the elderly 

  Rezai Kallaj, Mehdi (Doctoral thesis, 2024-09-13)

  Bakgrunn Nevrologiske lidelser utgjør en stor helsemessig utfordring og hjerneslag er globalt sett den nest hyppigste årsaken til død og den fremste årsaken til uførhet. Iskemisk hjerneslag behandles primært med medisinsk ...

• Streptococcus dysgalactiae Bloodstream Infections, Norway, 1999-2021 

  Oppegaard, Oddvar; Glambek, Marte; Skutlaberg, Dag Harald; Skrede, Steinar; Sivertsen, Audun; Kittang, Bård Reiakvam (Journal article; Peer reviewed, 2023)

  Streptococcus dysgalactiae increasingly is recognized as a pathogen of concern for human health. However, longitudinal surveillance data describing temporal trends of S. dysgalactiae are scarce. We retrospectively identified ...

• Imaging tumor lactate is feasible for identifying intermediate-risk prostate cancer patients with postsurgical biochemical recurrence 

  Sushentsev, Nikita; Hamm, Gregory; Richings, Jack; McLean, Mary A.; Menih, Ines Horvat; Ayyappan, Vinay; Mills, Ian Geoffrey; Warren, Anne Y.; Gnanapragasam, Vincent J.; Barry, Simon T.; Goodwin, Richard J.A.; Gallagher, Ferdia A.; Barrett, Tristan (Journal article; Peer reviewed, 2023)

  While radical prostatectomy remains the mainstay of prostate cancer (PCa) treatment, 20 to 40% of patients develop postsurgical biochemical recurrence (BCR). A particularly challenging clinical cohort includes patients ...

• Mutation Spectrum in Liquid Versus Solid Biopsies From Patients With Advanced astroenteropancreatic Neuroendocrine Carcinoma 

  Knappskog, Stian; Grob, Tobias; Venizelos, Andreas; Amstutz, Ursula; Hjortland, Geir Olav; Lothe, Inger Marie Bowitz; Kersten, Christian; Hofsli, Eva; Sundlöv, Anna; Elvebakken, Hege; Garresori, Herish; Couvelard, Anne; Svensson, Johanna; Sorbye, Halfdan; Perren, Aurel (Journal article; Peer reviewed, 2023)

  Purpose Gastroenteropancreatic neuroendocrine carcinomas (GEP-NEC) are rare and have a poor prognosis. Most GEP-NEC are diagnosed with metastatic disease, with only minor biopsies available for molecular diagnostics. We ...

• Outcomes of Patients With Graves Disease 25 Years After Initiating Antithyroid Drug Therapy 

  Stokland, Ann-Elin Meling; Austdal, Marie; Nedrebø, Bjørn Gunnar; Carlsen, Siri; Hetland, Hanne Brit; Breivik, Lars Ertesvåg; Ueland, Hans Olav; Watt, Torquil; Cramon, Per Karkov; Løvås, Kristian; Husebye, Eystein Sverre; Ueland, Grethe Åstrøm (Journal article; Peer reviewed, 2023)

  Context Graves disease (GD) is a leading cause of hyperthyroidism. Detailed investigations and predictors of long-term outcomes are missing. Objective This work aimed to investigate the outcomes in GD 25 years after ...

View more