• Diabetes and Osteoarthritis: Exploring the Interactions and Therapeutic Implications of Insulin, Metformin, and GLP-1-Based Interventions 

  Halabitska, Iryna; Babinets, Liliia; Oksenych, Valentyn; Kamyshnyi, Oleksandr (Journal article; Peer reviewed, 2024-07-23)

  Diabetes mellitus (DM) and osteoarthritis (OA) are prevalent chronic conditions with shared pathophysiological links, including inflammation and metabolic dysregulation. This study investigates the potential impact of ...

• Genomic insight into COVID-19 severity in MAFLD patients: a single-center prospective cohort study 

  Buchynskyi, Mykhailo; Oksenych, Valentyn; Kamyshna, Iryna; Budarna, Olena; Halabitska, Iryna; Petakh, Pavlo; Kamyshnyi, Oleksandr (Journal article; Peer reviewed, 2024-09-04)

  This study investigated the influence of single nucleotide polymorphisms (SNPs) in genes associated with the interferon pathway (IFNAR2 rs2236757), antiviral response (OAS1 rs10774671, OAS3 rs10735079), and viral entry ...

• Beta-Blockers of Different Generations: Features of Influence on the Disturbances of Myocardial Energy Metabolism in Doxorubicin-Induced Chronic Heart Failure in Rats 

  Belenichev, Igor; Goncharov, Olexiy; Bukhtiyarova, Nina; Kuchkovskyi, Oleh; Ryzhenko, Victor; Makyeyeva, Lyudmyla; Oksenych, Valentyn; Kamyshnyi, Oleksandr (Journal article; Peer reviewed, 2024-08-28)

  Beta-blockers are first-line drugs in the treatment of chronic heart failure (CHF). However, there is no consensus on the specific effects of the beta-blockers of the I-III generation on energy metabolism in CHF. The aim ...

• Development and Optimization of Nasal Composition of a Neuroprotective Agent for Use in Neonatology after Prenatal Hypoxia 

  Belenichev, Igor; Aliyeva, Olena; Burlaka, Bogdan; Burlaka, Kristina; Kuchkovskyi, Oleh; Savchenko, Dmytro; Oksenych, Valentyn; Kamyshnyi, Oleksandr (Journal article; Peer reviewed, 2024-07-26)

  The intranasal route of drug administration is characterized by high bioavailability and is considered promising for rapid delivery of drugs with systemic action to the central nervous system (CNS), bypassing the blood-brain ...

• Dysregulation of miR-223, miR-146a, and miR-193a Expression Profile in Acute and Chronic Phases of Experimental Autoimmune Encephalomyelitis in C57BL/6 Mice 

  Gharibi, Saba; Moghimi, Bahram; Mahmoudi, Mohammad Bagher; Shahvazian, Ensieh; Yazd, Ehsan Farashahi; Yadegari, Maryam; Tahoori, Mohammad Taher; Yazdanpanah, Esmaeil; Haghmorad, Dariush; Oksenych, Valentyn (Journal article; Peer reviewed, 2024-09-06)

  Multiple sclerosis (MS) is a chronic autoimmune disease with an unknown etiology. The purpose of this research was to assess miR-223, miR-146a, and miR-193a in acute and chronic phases of experimental autoimmune encephalomyelitis ...

• Identification of Black Cumin (Nigella sativa) MicroRNAs by Next-Generation Sequencing and Their Implications in Secondary Metabolite Biosynthesis 

  Uriostegui-Pena, Andrea G.; Reyes-Calderón, Almendra; Gutiérrez-García, Claudia; Srivastava, Aashish; Sharma, Ashutosh; Paul, Sujay (Journal article; Peer reviewed, 2024-10-08)

  Secondary metabolites are bioactive compounds believed to contribute to the pharmacological properties of plants. MicroRNAs (miRNAs) are small non-coding RNA molecules involved in post-transcriptional regulation and are ...

• Association between heavy alcohol consumption and cryptogenic ischaemic stroke in young adults: A case-control study 

  Martinez-Majander, Nicolas; Kutal, Shakar; Ylikotila, Pauli; Yesilot, Nilufer; Tulkki, Lauri; Zedde, Marialuisa; Sarkanen, Tomi; Junttola, Ulla; Nordanstig, Annika; Fromm, Annette; Ryliskiene, Kristina; Licenik, Radim; Ferdinand, Phillip; Jatuzis, Dalius; Kõrv, Liisa; Kõrv, Janika; Pezzini, Alessandro; Tuohinen, Suvi; Sinisalo, Juha; Lehto, Mika; Gerdts, Eva; Ryödi, Essi; Autere, Jaana; Hedman, Marja; Fonseca, Ana Catarina; Waje-Andreassen, Ulrike; Von Sarnowski, Bettina; Redfors, Petra; Sairanen, Tiina; Tatlisumak, Turgut; Roine, Risto O; Huhtakangas, Juha; Numminen, Heikki; Jäkälä, Pekka; Putaala, Jukka (Journal article; Peer reviewed, 2024)

  Background The underlying risk factors for young-onset cryptogenic ischaemic stroke (CIS) remain unclear. This multicentre study aimed to explore the association between heavy alcohol consumption and CIS with subgroup ...

• Impaired Periodontitis-Induced Cytokine Production by Peripheral Blood Monocytes and Myeloid Dendritic Cells in Patients with Rheumatoid Arthritis: A Case–Control Study 

  Silva, Daniela S.; Laranjeira, Paula; Silva, Ana; Silva, Isabel; Kaminska, Marta; Mydel, Piotr Mateusz; de Vries, Charlotte; Lundberg, Karin; da Silva, José António P.; Baptista, Isabel P.; Paiva, Artur (Journal article; Peer reviewed, 2024)

  Background: Immune cells from rheumatoid arthritis (RA) patients display a reduced in vitro response to Porphyromonas gingivalis (P. gingivalis), which may have functional immune consequences. The aim of this study was to ...

• Heart failure with improved versus persistently reduced left ventricular ejection fraction: A comparison of the BIOSTAT-CHF (European) study with the ASIAN-HF registry 

  Cao, Thong Huy; Tay, Wan Ting; Jones, Donald J.L.; Cleland, John G.F.; Tromp, Jasper; Emmens, Johanna Elisabeth; Teng, Tiew-Hwa Katherine; Chandramouli, Chanchal; Slingsby, Oliver Charles; Anker, Stefan D.; dickstein, kenneth; Filippatos, Gerasimos; Lang, Chim C.; Metra, Marco; Ponikowski, Piotr; Samani, Nilesh J.; Van Veldhuisen, Dirk J.; Zannad, Faiez; Anand, Inder S.; Lam, Carolyn S.P.; Voors, Adriaan A.; Ng, Leong L. (Journal article; Peer reviewed, 2024)

  Aims We investigated the prevalence, clinical characteristics, and prognosis of patients with heart failure (HF) with improved ejection fraction (HFimpEF). Methods and results We used data from BIOSTAT-CHF including ...

• Overall survival in patients with endometrial cancer treated with dostarlimab plus carboplatin–paclitaxel in the randomized ENGOT-EN6/GOG-3031/RUBY trial 

  Powell, M.A.; Bjørge, Line; Willmott, L.; Novák, Z.; Black, D.; Gilbert, L.; Sharma, S.; Valabrega, G.; Landrum, L.M.; Gropp-Meier, M.; Stuckey, A.; Boere, I.; Gold, M.A.; Segev, Y.; Gill, S.E.; Gennigens, C.; Sebastianelli, A.; Shahin, M.S.; Pothuri, B.; Monk, B.J.; Buscema, J.; Coleman, R.L.; Slomovitz, B.M.; Ring, K.L.; Herzog, T.J.; Balas, M.M.; Grimshaw, M.; Stevens, S.; Lai, D.W.; McCourt, C.; Mirza, M.R. (Journal article; Peer reviewed, 2024)

  Background: Part 1 of the RUBY trial (NCT03981796) evaluated dostarlimab plus carboplatin–paclitaxel compared with placebo plus carboplatin–paclitaxel in patients with primary advanced or recurrent endometrial cancer (EC). ...

• A study of microRNAs as new prognostic biomarkers in anal cancer patients 

  Dahl, Olav; Myklebust, Mette Pernille (Journal article; Peer reviewed, 2024)

  Background: MicroRNA (MiR) influences the growth of cancer by regulation of mRNA for 50–60% of all genes. We present as per our knowledge the first global analysis of microRNA expression in anal cancer patients and their ...

• A retrospective study of non-ventilator hospital-acquired pneumonia in a Norwegian hospital: a serious medical condition in need of better and timelier microbiological diagnostics 

  Feet, Jon Anders; Müller, Karl Erik; Grewal, Harleen; Ulvestad, Elling; Heggelund, Lars (Journal article; Peer reviewed, 2024)

  Background: Hospital-acquired pneumonia (HAP) is the most common hospital-acquired infection (HAI). HAP is associated with a high burden of morbidity and mortality, but the diagnosis is difficult to establish and the ...

• Identification of novel genomic loci for anxiety symptoms and extensive genetic overlap with psychiatric disorders 

  Tesfaye, Markos; Jaholkowski, Piotr Pawel; Shadrin, Alexey; van der Meer, Dennis; Hindley, Guy; Holen, Børge; Parker, Nadine; Parekh, Pravesh; Birkenæs, Viktoria; Rahman, Mohammad Zillur; Bahrami, Shahram; Kutrolli, Gleda; Frei, Oleksandr; Djurovic, Srdjan; Dale, Anders M; Smeland, Olav Bjerkehagen; O'Connell, Kevin Sean; Andreassen, Ole A. (Journal article; Peer reviewed, 2024)

  Aims: Anxiety disorders are prevalent and anxiety symptoms (ANX) co-occur with many psychiatric disorders. We aimed to identify genomic loci associated with ANX, characterize its genetic architecture, and genetic overlap ...

• Clinical profile, microbiology and outcomes in infective endocarditis treated with aortic valve replacement: a multicenter case-control study 

  Dingen, Håvard; Jordal, Stina; Bratt, Sorosh; Aukrust, Pål; Busund, Rolf; Jakobsen, Øyvind; Dalén, Magnus; Ueland, Thor; Svenarud, Peter; Haaverstad, Rune; Saeed, Sahrai; Risnes, Ivar (Journal article; Peer reviewed, 2024)

  Background Aortic valve infective endocarditis (IE) is associated with significant morbidity and mortality. We aimed to describe the clinical profile, risk factors and predictors of short- and long-term mortality in ...

• Associations between fetal position at delivery and duration of active phase of labor: A historical cohort study 

  Eide, Birgitte; Sande, Ragnar; Von Brandis, Phillip; Kessler, Jørg; Tappert, Christian; Eggebø, Torbjørn Moe (Journal article; Peer reviewed, 2024)

  Introduction In clinical experience, occiput posterior (OP) position is associated with longer labor duration than occiput anterior (OA) position, but few studies have investigated the association between labor duration ...

• European Society of Endocrinology and Endocrine Society Joint Clinical Guideline: Diagnosis and Therapy of Glucocorticoid-induced Adrenal Insufficiency 

  Beuschlein, Felix; Else, Tobias; Bancos, Irina; Hahner, Stefanie; Hamidi, Oksana; Van Hulsteijn, Leonie; Husebye, Eystein Sverre; Karavitaki, Niki; Prete, Alessandro; Vaidya, Anand; Yedinak, Christine; Dekkers, Olaf M (Journal article; Peer reviewed, 2024)

  Glucocorticoids are widely prescribed as anti-inflammatory and immunosuppressive agents. This results in at least 1% of the population using chronic glucocorticoid therapy, being at risk for glucocorticoid-induced adrenal ...

• The Surviving, Not Thriving, Photoreceptors in Patients with ABCA4 Stargardt Disease 

  De Bruyn, Hanna; Johnson, Megan; Moretti, Madelyn; Ahmed, Saleh; Mujat, Mircea; Akula, James D.; Glavan, Tomislav; Mihalek, Ivana; Aslaksen, Sigrid; Molday, Laurie L.; Molday, Robert S.; Berkowitz, Bruce A.; Fulton, Anne B. (Journal article; Peer reviewed, 2024)

  Stargardt disease (STGD1), associated with biallelic variants in the ABCA4 gene, is the most common heritable macular dystrophy and is currently untreatable. To identify potential treatment targets, we characterized surviving ...

• Robust and persistent B-cell responses following SARS-CoV-2 vaccine determine protection from SARS-CoV-2 infection 

  Byrne, Joanne; Gu, Lili; Garcia-Leon, Alejandro; Gaillard, Colette Marie; Saini, Gurvin; Alalwan, Dana; Tomás-Cortázar, Julen; Kenny, Grace; Donohue, Sean; Reynolds, Bearach; O'Gorman, Tessa; Landay, Alan; Doran, Peter; Stemler, Jannik; Koehler, Philipp; Cox, Rebecca Jane; Olesen, Ole F.; Lelievre, Jean-Daniel; O'Broin, Cathal; Savinelli, Stefano; Feeney, Eoin R.; O'Halloran, Jane A.; Cotter, Aoife; Horgan, Mary; Kelly, Christine; Sadlier, Corrina; de Barra, Eoghan; Cornely, Oliver A.; Gautier, Virginie; Mallon, Patrick Wg (Journal article; Peer reviewed, 2024-09-17)

  Introduction: A clear immune correlate of protection from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has not been defined. We explored antibody, B-cell, and T-cell responses to the third-dose ...

• Randomized controlled trial reveals no benefit to a 3-month delay in COVID-19 mRNA booster vaccine 

  Lee, Wen Shi; Audsley, Jennifer; Trieu, Mai Chi; Reynaldi, Arnold; Aurelia, L Carissa; Mehta, Palak H.; Patterson, Joanne; Kent, Helen E.; Nguyen, Julie; Amarasena, Thakshila; Esterbauer, Robyn; Haycroft, Ebene R.; Ramanathan, Pradhipa; Davenport, Miles P.; Schlub, Timothy E.; Sasadeusz, Joseph; Wheatley, Adam K.; Chung, Amy W.; Juno, Jennifer A.; Selva, Kevin J.; Kent, Stephen J. (Journal article; Peer reviewed, 2024)

  BACKGROUND. There is uncertainty about the timing of booster vaccination against COVID-19 in highly vaccinated populations during the present endemic phase of COVID-19. Studies focused on primary vaccination have previously ...

• Carotid plaque offsets sex-related differences in cardiovascular risk of young hypertensive patients 

  Mancusi, Costantino; Basile, Christian; Gerdts, Eva; Fucile, Ilaria; Manzi, Maria Virginia; Lembo, Maria; Pacella, Daniela; Giugliano, Giuseppe; Canciello, Grazia; Piccolo, Raffaele; Spinelli, Alessandra; Morisco, Carmine; De Luca, Nicola; Trimarco, Bruno; de Simone, Giovanni; Bossone, Eduardo; Izzo, Raffaele; Losi, Maria Angela; Esposito, Giovanni (Journal article; Peer reviewed, 2024)

  Background: Women have a lower risk for cardiovascular (CV) disease compared to men. Whether this difference is influenced by the presence of hypertension-mediated organ damage is unknown. Objective: To assess whether ...

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