• Chronically elevated exogenous glucose elicits antipodal effects on the proteome signature of differentiating human iPSC-derived pancreatic progenitors 

  Ghila, Luiza; Legøy, Thomas Aga; Mathisen, Andreas Frøslev; Abadpour, Shadab; Paulo, Joao A.; Scholz, Hanne Bjørnson; Ræder, Helge; Chera, Simona (Journal article; Peer reviewed, 2021-04-02)

  The past decade revealed that cell identity changes, such as dedifferentiation or transdifferentiation, accompany the insulin-producing β-cell decay in most diabetes conditions. Mapping and controlling the mechanisms ...

• Prediction of type 1 diabetes at birth: Cord blood metabolites vs genetic risk score in the Norwegian mother, father, and child cohort 

  Tapia, German; Suvitaival, Tommi; Ahonen, Linda; Lund-Blix, Nicolai Andre; Njølstad, Pål Rasmus; Joner, Geir; Skrivarhaug, Torild; Legido-Quigley, Cristina; Størdal, Ketil; Stene, Lars Christian Mørch (Journal article; Peer reviewed, 2021)

  Background and aim: Genetic markers are established as predictive of type 1 diabetes, but unknown early life environment is believed to be involved. Umbilical cord blood may reflect perinatal metabolism and exposures. We ...

• Sex disparity in acute myeloid leukaemia with FLT3 internal tandem duplication mutations: implications for prognosis 

  Hellesøy, Monica; Engen, Caroline Benedicte Nitter; Grob, Tim; Löwenberg, Bob; Valk, Peter J. M.; Gjertsen, Bjørn T. (Journal article; Peer reviewed, 2021)

  Incidence, molecular presentation and outcome of acute myeloid leukaemia (AML) are influenced by sex, but little attention has been directed at untangling sex-related molecular and phenotypic differences between female and ...

• A human iPSC-astroglia neurodevelopmental model reveals divergent transcriptomic patterns in schizophrenia 

  Szabo, Attila; Akkouh, Ibrahim Ahmed; Vandenberghe, Matthieu; Osete, Jordi Requena; Hughes, Timothy; Heine, Vivi M.; Smeland, Olav Bjerkehagen; Glover, Joel Clinton; Andreassen, Ole; Djurovic, Srdjan (Journal article; Peer reviewed, 2021)

  While neurodevelopmental abnormalities have been associated with schizophrenia (SCZ), the role of astroglia in disease pathophysiology remains poorly understood. In the present study, we used a human induced pluripotent ...

• A whole blood based resuscitation strategy in civilian medical services: Experience from a Norwegian hospital in the period 2017–2020 

  Hagen, Kristin Gjerde; Strandenes, Geir; Kristoffersen, Einar Klæboe; Braathen, Hanne; Sivertsen, Joar; Bjerkvig, Christopher Kalhagen; Sommerfelt-Pettersen, Nina Grindheim; Aasheim, Irmelin Beathe; Lunde, Turid Helen Felli; Hervig, Tor; Apelseth, Torunn Oveland (Journal article; Peer reviewed, 2021)

  Background: Civilian and military guidelines recommend early balanced transfusion to patients with life-threatening bleeding. Low titer group O whole blood was introduced as the primary blood product for resuscitation of ...

• Early manifestations of genetic risk for neurodevelopmental disorders 

  Askeland, Ragna Bugge; Hannigan, Laurie J.; Ask, Helga; Ayorech, Ziada; Tesli, Martin Steen; Corfield, Elizabeth; Magnus, Per Minor; Njølstad, Pål Rasmus; Andreassen, Ole A.; Smith, George Davey; Reichborn-Kjennerud, Ted; Havdahl, Alexandra (Journal article; Peer reviewed, 2021)

  Background: Attention deficit/hyperactivity disorder (ADHD), autism spectrum disorder (autism) and schizophrenia are highly heritable neurodevelopmental disorders, affecting the lives of many individuals. It is important ...

• The natural history of 21-hydroxylase autoantibodies in autoimmune Addison’s disease 

  Wolff, Anette Susanne Bøe; Breivik, Lars Ertesvåg; Hufthammer, Karl Ove; Grytaas, Marianne; Bratland, Eirik; Husebye, Eystein Sverre; Oftedal, Bergithe Eikeland (Journal article; Peer reviewed, 2021)

  Background: The most common cause of primary adrenal failure (Addison’s disease) in the Western world is autoimmunity characterized by autoantibodies against the steroidogenic enzyme 21-hydroxylase (CYP21A2, 21OH). Detection ...

• Chip protein U-box domain truncation affects Purkinje neuron morphology and leads to behavioral changes in zebrafish 

  Pakdaman, Yasaman; Denker, Elsa; Austad, Eirik; Norton, William H.J.; Rolfsnes, Hans Olav; Bindoff, Laurence Albert; Tzoulis, Charalampos; Aukrust, Ingvild; Knappskog, Per Morten; Johansson, Stefan; Ellingsen, Ståle (Journal article; Peer reviewed, 2021-09-24)

  The ubiquitin ligase CHIP (C-terminus of Hsc70-interacting protein) is encoded by STUB1 and promotes ubiquitination of misfolded and damaged proteins. CHIP deficiency has been linked to several diseases, and mutations in ...

• Interleukin-2 receptor in the pathogenesis of diabetic complications and Sjögren's syndrome 

  Keindl, Magdalena (Doctoral thesis, 2021-12-14)

  The cytokine interleukin-2 (IL-2) acts as a double-edged sword by promoting both immunity and immune tolerance. Regulatory T cells (Tregs) are responsible for maintaining self-tolerance and constitutively express the high ...

• Immunohistochemical biomarkers are prognostic relevant in addition to the ESMO-ESGO-ESTRO risk classification in endometrial cancer 

  Vrede, S.W.; van Weelden, Willem Jan; Visser, Nicole C.M.; Bulten, Johan; Van Der Putten, Louis J.M.; Van De Vijver, Koen; Santacana, Maria; Colas, Eva; Gil-Moreno, Antonio; Moiola, Cristian P.; Mancebo, Gemma; Krakstad, C.; Trovik, J.; Haldorsen, Ingfrid S.; Huvila, Jutta; Koskas, Martin; Weinberger, Vit; Bednarikova, M.; Hausnerova, Jitka; van der Wurff, der; Matias-Guiu, Xavier; Amant, Frédéric; Snijders, Marc P.L.M.; Küsters-Vandevelde, Heidi V.N.; Reijnen, Casper; Pijnenborg, Johanna M.A. (Journal article; Peer reviewed, 2021)

  Objective: Pre-operative immunohistochemical (IHC) biomarkers are not incorporated in endometrial cancer (EC) risk classification. We aim to investigate the added prognostic relevance of IHC biomarkers to the ESMO-ESGO-ESTRO ...

• Improved pH-Responsive Release of Phenformin from Low-Defect Graphene Compared to Graphene Oxide 

  Alhourani, Abdelnour; Førde, Jan-Lukas; Eichacker, Lutz Andreas; Herfindal, Lars; Hagland, Hanne Røland (Journal article; Peer reviewed, 2021)

  Graphene-based drug carriers provide a promising addition to current cancer drug delivery options. Increased accessibility of high-quality graphene made by plasma-enhanced chemical vapor deposition (PE-CVD) makes it an ...

• A 10-gene prognostic signature points to LIMCH1 and HLA-DQB1 as important players in aggressive cervical cancer disease 

  Halle, Mari Kyllesø; Sødal, Marte; Forsse, David Erik; Engerud, Hilde Renate; Woie, Kathrine; Lura, Njål Gjærde; Wagner-Larsen, Kari Strøno; Trovik, Jone; Bertelsen, Bjørn; Haldorsen, Ingfrid S.; Ojesina, Akinyemi I.; Krakstad, Camilla (Journal article; Peer reviewed, 2021)

  Background: Advanced cervical cancer carries a particularly poor prognosis, and few treatment options exist. Identification of effective molecular markers is vital to improve the individualisation of treatment. We investigated ...

• Baked cod consumption delayed the development of kidney and liver dysfunction and affected plasma amino acid concentrations, but did not affect blood pressure, blood glucose or liver triacylglycerol concentrations in obese fa/fa Zucker rats. 

  Vikøren, Linn A.; Drotningsvik, Aslaug; Midttun, Øivind; McCann, Adrian; Bergseth, Marthe Tønder; Austgulen, Maren H.; Mellgren, Gunnar; Ueland, Per Magne; Gudbrandsen, Oddrun Anita (Journal article; Peer reviewed, 2021)

  Obesity is associated with changes in amino acid metabolism, and studies show that ingestion of fish proteins influence amino acid composition in plasma and urine, in addition to affecting risk factors for metabolic syndrome. ...

• Lower circulating neuron-specific enolase concentrations in adults and adolescents with severe mental illness 

  Andreou, Dimitrios; Steen, Nils Eiel; Jørgensen, Kjetil Nordbø; Smelror, Runar Elle; Wedervang-Resell, Kirsten; Nerland, Stener; Westlye, Lars Tjelta; Nærland, Terje; Myhre, Anne Margrethe; Joa, Inge; Reitan, Solveig Merete Klæbo; Vaaler, Arne; Morken, Gunnar; Bøen, Erlend; Elvsåshagen, Torbjørn; Boye, Birgitte; Malt, Ulrik Fredrik; Aukrust, Pål; Skrede, Silje; Kroken, Rune Andreas; Johnsen, Erik; Djurovic, Srdjan; Andreassen, Ole; Ueland, Thor; Agartz, Ingrid (Journal article; Peer reviewed, 2021)

  Background: Both neurodegenerative and neurodevelopmental abnormalities have been suggested to be part of the etiopathology of severe mental illness (SMI). Neuron-specific enolase (NSE), mainly located in the neuronal ...

• IL-18 and IL-18 binding protein are related to disease severity and parasitemia during falciparum malaria 

  Otterdal, Kari; Berg, Åse; Michelsen, Annika Elisabet; Yndestad, Arne; Patel, Sam; Gregersen, Ida; Halvorsen, Bente; Ueland, Thor; Langeland, Nina; Aukrust, Pål (Journal article; Peer reviewed, 2021)

  Background: Several inflammatory molecules participate in the immune response to malaria. Interleukin (IL)-18 is an inflammatory cytokine activated by NLRP3 inflammasomes. In clinical falciparum malaria, with and without ...

• Novel neonatal simulator provides high-fidelity ventilation training comparable to real-life newborn ventilation 

  Haynes, Joanna; Bjorland, Peder Aleksander; Gomo, Øystein; Ushakova, Anastasia; Rettedal, Siren; Perlman, Jeffrey M.; Ersdal, Hege Langli (Journal article; Peer reviewed, 2021)

  Face mask ventilation of apnoeic neonates is an essential skill. However, many non-paediatric healthcare personnel (HCP) in high-resource childbirth facilities receive little hands-on real-life practice. Simulation training ...

• Liquid Biopsies in Solid Cancers: Implementation in a Nordic Healthcare System 

  Nordgård, Oddmund; Forthun, Rakel Brendsdal; Lapin, Morten; Grønberg, Bjørn Henning; Kalland, Karl Henning; Kopperud, Reidun Kristin; Thomsen, Liv Cecilie Vestrheim; Tjensvoll, Kjersti; Gilje, Bjørnar; Gjertsen, Bjørn Tore; Hovland, Randi (Journal article; Peer reviewed, 2021)

  Liquid biopsies have emerged as a potential new diagnostic tool, providing detailed information relevant for characterization and treatment of solid cancers. We here present an overview of current evidence supporting the ...

• Meal patterns associated with energy intake in people with obesity 

  Horn, Cathrine; Laupsa-Borge, Johnny; Andersen, Amanda; Dyer, Laurence; Revheim, Ingrid; Leikanger, Trine; Næsheim, Nicole Tandrevold; Storås, Inghild; Johannessen, Kristine Kjerpeseth; Mellgren, Gunnar; Dierkes, Jutta; Dankel, Simon Erling Nitter (Journal article; Peer reviewed, 2021)

  It is widely assumed that people with obesity have several common eating patterns, including breakfast-skipping (1), eating during the night (2) and high fast-food consumption (3). However, differences in individual meal ...

• The association between intrapartum opioid fentanyl and early breastfeeding: A prospective observational study 

  Oommen, Hanna; Tveit, Tor Oddbjørn; Eskedal, Leif Torvald; Myr, Rachel; Swanson, David Michael; Vistad, Ingvild (Journal article; Peer reviewed, 2021)

  Introduction: Intrapartum opioids in labor may interfere with the early breastfeeding phase and cause breastfeeding difficulties. This study examines the effects of intrapartum fentanyl given intravenously (IV) or through ...

• Proteomic Comparison of Bone Marrow Derived Osteoblasts and Mesenchymal Stem Cells 

  Aasebø, Elise; Brenner, Annette; Hernandez-Valladares, Maria; Birkeland, Even; Berven, Frode Steingrimsen; Selheim, Frode; Bruserud, Øystein (Journal article; Peer reviewed, 2021)

  Mesenchymal stem cells (MSCs) can differentiate into osteoblasts, and therapeutic targeting of these cells is considered both for malignant and non-malignant diseases. We analyzed global proteomic profiles for osteoblasts ...

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