Department of Clinical Science
Recent Submissions
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Increasing region of interest width reduces neonatal circumferential strain
(Journal article; Peer reviewed, 2024)Objective There is growing interest in speckle tracking echocardiography-derived strain as a measure of left ventricular function in neonates. However, knowledge gaps remain regarding the effect of image acquisition and ... -
Quantified planar collagen distribution in healthy and degenerative mitral valve: biomechanical and clinical implications
(Journal article; Peer reviewed, 2024)Degenerative mitral valve disease is a common valvular disease with two arguably distinct phenotypes: fibroelastic deficiency and Barlow’s disease. These phenotypes significantly alter the microstructures of the leaflets, ... -
'When age is not a barrier': an explorative study of nonagenarian patients' experiences of undergoing percutaneous coronary intervention
(Journal article; Peer reviewed, 2024)Aims The recent rise in the number of nonagenarians (age ≥ 90 years) undergoing percutaneous coronary intervention (PCI) has revealed gaps in research, in particular on patients’ experiences. Therefore, the aim of the ... -
α1-Antichymotrypsin Complex (SERPINA3) Is an Independent Predictor of All-Cause but Not Cardiovascular Mortality in Patients Hospitalized for Chest Pain of Suspected Coronary Origin
(Journal article; Peer reviewed, 2024)Introduction: SERPINA3 is an acute phase protein triggered by inflammation. It is upregulated after an acute myocardial infarction (AMI). Data on its long-term prognostic value in MI patients are scarce. We aimed to assess ... -
Monocytic Differentiation in Acute Myeloid Leukemia Cells: Diagnostic Criteria, Biological Heterogeneity, Mitochondrial Metabolism, Resistance to and Induction by Targeted Therapies
(Journal article; Peer reviewed, 2024)We review the importance of monocytic differentiation and differentiation induction in non-APL (acute promyelocytic leukemia) variants of acute myeloid leukemia (AML), a malignancy characterized by proliferation of immature ... -
Time trends and birth rates in women with congenital heart disease; a nationwide cohort study from Norway 1994–2014
(Journal article; Peer reviewed, 2024)Background: More women with congenital heart disease (CHD) reach reproductive age, but little is known of their success in having children. We investigated time trends of CHD in women of reproductive age and maternal CHD ... -
Recurrent laryngeal nerve injury and nerve recovery evaluated by EMG, accelerometry and direct laryngoscopy : -An experimental approach -
(Doctoral thesis, 2024-12-13)Den mest fryktede komplikasjonen ved endokrinkirurgi på hals er bilateral skade på nervus laryngeus rekurrens (RLN) som kan føre til lammelse av stemmebåndene, ledsaget av alvorlige respirasjonsproblemer som kan ende i ... -
Lung function in Norway in the 20th century : Trends, lower limits of normality and overall and specific mortalities
(Doctoral thesis, 2024-12-06)Bakgrunn og mål: Lungefunksjon er en markør for generell helse og kan predikere mortalitet. Flere faktorer påvirker måling og tolkning av lungefunksjon i en befolkning. Målet med dette doktorgradsarbeidet var å studere den ... -
Preoperative risk factors associated with left ventricular dysfunction after bariatric surgery
(Journal article; Peer reviewed, 2024)A large proportion of patients with severe obesity remain with left ventricular (LV) dysfunction after bariatric surgery. We assessed whether preoperative evaluation by echocardiography and inflammatory proteins can identify ... -
Prognostic factors, treatment approach and clinical outcomes from glioblastoma: a population-based observational cohort study from Western Norway
(Doctoral thesis, 2024-12-06)Bakgrunn: Glioblastom er den vanligste og mest aggressive primære hjernesvulst hos voksne, og prognosen er svært alvorlig med median overlevelse på omtrent 15 måneder tross standard behandling med radiokjemoterapi. I klinisk ... -
Left ventricular mechanics and oxygen demand in patients with severe obesity undergoing Roux-en-Y gastric bypass surgery
(Doctoral thesis, 2024-11-29)Bakgrunn og mål: Venstre ventrikkel (VV) er eksponert for kronisk trykk- og volumoverbelastning ved alvorlig fedme. Effekten av vektreduserende kirurgi på fedme-relatert VV-dysfunksjon har ikke vært kartlagt i detalj ... -
The NORwegian atrial fibrillation self-SCREENing (NORSCREEN) trial: rationale and design of a randomized controlled trial
(Journal article; Peer reviewed, 2024)Aims Atrial fibrillation (AF) is a common arrhythmia, and many cases of AF may be undiagnosed. Whether screening for AF and subsequent treatment if AF is detected can improve long-term outcome remains an unsettled ... -
HyperTraPS-CT: Inference and prediction for accumulation pathways with flexible data and model structures
(Journal article; Peer reviewed, 2024-09-04)Accumulation processes, where many potentially coupled features are acquired over time, occur throughout the sciences from evolutionary biology to disease progression, and particularly in the study of cancer progression. ... -
SARS-CoV-2 infection in healthcare workers, and biomarkers of long COVID
(Doctoral thesis, 2024-11-27)I denne doktorgradsavhandlingen har vi studert risikoen for å bli smittet av SARS-CoV-2 virus blant norske helsearbeidere gjennom de ulike covid-19 smittebølgene. Kunnskap om prevalens og risikofaktorer for smitte hos ... -
Prostate Biopsies Can Be Omitted in Most Patients with a Positive Stockholm3 Test and Negative Prostate Magnetic Resonance Imaging
(Journal article; Peer reviewed, 2024)Background Magnetic resonance imaging (MRI) combined with the Stockholm3 test can be used to inform biopsy decision-making in patients with a suspicion of prostate cancer. Objective To determine the consequence of ... -
Effect of Therapeutic Drug Monitoring on Adherence and Blood Pressure: A Multicenter Randomized Clinical Trial
(Journal article; Peer reviewed, 2024)Background: Drug concentration in blood or urine is an acknowledged method to detect nonadherence. Observational studies suggest that informing patients about low or absent serum drug levels improves blood pressure (BP). ... -
Efficient CAR T cell targeting of the CA125 extracellular repeat domain of MUC16
(Journal article; Peer reviewed, 2024)Background Ovarian cancer (OC) is the leading cause of death from gynecologic malignancies in the Western world. Contributing factors include a high frequency of late-stage diagnosis, the development of chemoresistance, ... -
Characterisation of global and regional mitral annular strains in an acute porcine model
(Journal article, 2024)OBJECTIVES This study aimed to explore regional mitral annular strain using a novel computational method. METHODS Eight pigs underwent implantation with piezoelectric transducers around the mitral annulus. Interventions ... -
Association between dietary macronutrient composition and plasma one-carbon metabolites and B-vitamin cofactors in patients with stable angina pectoris
(Journal article; Peer reviewed, 2024)Elevated plasma concentrations of several one-carbon metabolites are associated with increased CVD risk. Both diet-induced regulation and dietary content of one-carbon metabolites can influence circulating concentrations ... -
Extracellular matrix remodelling pathway in peripheral blood mononuclear cells from severe COVID-19 patients: an explorative study
(Journal article; Peer reviewed, 2024)There is a reciprocal relationship between extracellular matrix (ECM) remodelling and inflammation that could be operating in the progression of severe COVID-19. To explore the immune-driven ECM remodelling in COVID-19, ...