Department of Clinical Science
Recent Submissions
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Residual Corticosteroid Production in Autoimmune Addison Disease
(Journal article; Peer reviewed, 2020)Design: Two-staged, cross-sectional clinical study in 17 centers (Norway, Sweden, and Germany). Residual glucocorticoid (GC) production was defined as quantifiable serum cortisol and 11-deoxycortisol and residual ... -
Human mucosal IgA immune responses against enterotoxigenic escherichia coli
(Journal article; Peer reviewed, 2020-08-29)Infection with enterotoxigenic Escherichia coli (ETEC) is a major contributor to diarrheal illness in children in low- and middle-income countries and travelers to these areas. There is an ongoing effort to develop vaccines ... -
Bioinformatic analyses of miRNA-mRNA signature during hiPSC differentiation towards insulin-producing cells upon HNF4α mutation
(Journal article; Peer reviewed, 2020)Mutations in the hepatocyte nuclear factor 4α (HNF4α) gene affect prenatal and postnatal pancreas development, being characterized by insulin-producing β-cell dysfunction. Little is known about the cellular and molecular ... -
The core clock transcription factor BMAL1 drives circadian β-cell proliferation during compensatory regeneration of the endocrine pancreas
(Journal article; Peer reviewed, 2020)Circadian clocks in pancreatic islets participate in the regulation of glucose homeostasis. Here we examined the role of these timekeepers in β-cell regeneration after the massive ablation of β cells by doxycycline-induced ... -
Effects of a multicomponent high intensity exercise program on physical function and health-related quality of life in older adults with or at risk of mobility disability after discharge from hospital: a randomised controlled trial
(Journal article; Peer reviewed, 2020)Background Many older people suffer from mobility limitations and reduced health-related quality of life (HRQOL) after discharge from hospital. A consensus regarding the most effective exercise-program to optimize physical ... -
Endoplasmic Reticulum Calcium Pumps and Tumor Cell Differentiation
(Journal article; Peer reviewed, 2020)Endoplasmic reticulum (ER) calcium homeostasis plays an essential role in cellular calcium signaling, intra-ER protein chaperoning and maturation, as well as in the interaction of the ER with other organelles. Calcium is ... -
The novel microRNAs hsa-miR-nov7 and hsamiR- nov3 are over-expressed in locally advanced breast cancer
(Journal article; Peer reviewed, 2020)miRNAs are an important class of small non-coding RNAs, which play a versatile role in gene regulation at the post-transcriptional level. Expression of miRNAs is often deregulated in human cancers. We analyzed small RNA ... -
Association of adult lung function with accelerated biological aging
(Journal article; Peer reviewed, 2020)Lung function, strongly associated with morbidity and mortality, decreases with age. This study examines whether poor adult lung function is associated with age accelerations (AAs). DNA methylation (DNAm) based AAs, lifespan ... -
References for ultrasound staging of breast maturation, tanner breast staging, pubic hair, and menarche in Norwegian girls
(Journal article; Peer reviewed, 2020)Context: Discriminating adipose and glandular tissue is challenging when clinically assessing breast development. Ultrasound facilitates staging of pubertal breast maturation (US B), but has not been systematically compared ... -
Gene Methylation and Silencing of WIF1 Is a Frequent Genetic Abnormality in Mantle Cell Lymphoma
(Journal article; Peer reviewed, 2021)We have previously shown that the Wnt canonical pathway (WCP) is constitutively active in most cases of mantle cell lymphoma (MCL). Here, we aimed to elucidate the mechanisms underlying this biochemical deregulation. We ... -
Incremental costs of COPD exacerbations in GOLD stage 2+ COPD in ever-smokers of a general population
(Journal article; Peer reviewed, 2020-11)Objectives To estimate treatment- and productivity-related costs associated with COPD in two different samples, and to analyse the association between the costs and moderate and severe exacerbations. Methods We performed ... -
Runaway multi-allelic copy number variation at the α-defensin locus in African and Asian populations
(Journal article; Peer reviewed, 2020-06-04)Alpha defensins are anti-microbial peptides of the innate immune system. The defensin A1 and A3 genes are located in a repeat array of variable copy number (the DEFA1A3 locus) and encode the human neutrophil peptides 1, 2 ... -
NLRP3 inflammasome deficiency attenuates metabolic disturbances involving alterations in the gut microbial profile in mice exposed to high fat diet
(Journal article; Peer reviewed, 2020)Obesity-related diseases (e.g. type 2 diabetes mellitus and cardiovascular disorders) represent an increasing health problem worldwide. NLRP3 inflammasome activation may underlie obesity-induced inflammation and insulin ... -
Point Shear Wave Elastography and the Effect of Physical Exercise, Alcohol Consumption, and Respiration in Healthy Adults
(Journal article; Peer reviewed, 2020)Purpose Ultrasound elastography is a noninvasive method for liver stiffness measurement (LSM) with the aim of reflecting approximate liver fibrosis load. Despite minimal evidence, current guidelines recommend 10 min of ... -
Hormone references for ultrasound breast staging and endocrine profiling to detect female onset of puberty
(Journal article; Peer reviewed, 2020)Context Application of ultrasound (US) to evaluate attainment and morphology of glandular tissue provides a new rationale for evaluating onset and progression of female puberty, but currently no hormone references complement ... -
Hemophagocytic lymphohistiocytosis and miliary tuberculosis in a previously healthy individual: a case report
(Journal article; Peer reviewed, 2020)Background Hemophagocytic lymphohistiocytosis (HLH) is a rare heterogenous genetic or acquired hyperinflammatory syndrome associated with a high degree of morbidity and mortality. HLH has clinical manifestations related ... -
The PPAR pan-agonist tetradecylthioacetic acid promotes redistribution of plasma cholesterol towards large HDL
(Journal article; Peer reviewed, 2020)Tetradecylthioacetic acid (TTA) is a synthetic fatty acid with a sulfur substitution in the β-position. This modification renders TTA unable to undergo complete β-oxidation and increases its biological activity, including ... -
High prevalence of fecal carriage of extended spectrum β-lactamase-producing enterobacteriaceae among newly HIV-diagnosed adults in a community setting in Tanzania
(Journal article; Peer reviewed, 2020)Colonization in HIV-infected populations with extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-PE) is particularly worrisome in low-income settings. This study describes the prevalence of ESBL-PE carriage ... -
How important are parents in the development of child anxiety and depression? A genomic analysis of parent-offspring trios in the Norwegian Mother Father and Child Cohort Study (MoBa)
(Journal article; Peer reviewed, 2020)Background Many studies detect associations between parent behaviour and child symptoms of anxiety and depression. Despite knowledge that anxiety and depression are influenced by a complex interplay of genetic and ... -
Maintained survival outcome after reducing lymphadenectomy rates and optimizing adjuvant treatment in endometrial cancer
(Journal article; Peer reviewed, 2020)Objective Main controversies in endometrial cancer treatment include the role of lymphadenectomy and optimal adjuvant treatment. We assessed clinical outcome in a population-based endometrial cancer cohort in relation to ...
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