• Thrombectomy in large vessel occlusion stroke—Does age matter? 

  Rezai Kallaj, Mehdi; Dalen, Ingvild; Advani, Rajiv; Fjetland, Lars; Kurz, Kathinka Dæhli; Sandve, Knut Olav Lende; Kurz, Friedrich Martin Wilhelm (Journal article; Peer reviewed, 2022)

  Objectives Endovascular treatment (EVT) is the gold standard treatment for emergent large vessel occlusion (LVO). The benefit of EVT for emergent LVO in elderly patients (>80 years old) is still debated as they have been ...

• Genome-wide association study identifies Sjögren’s risk loci with functional implications in immune and glandular cells 

  Khatri, Bhuwan; Tessneer, Kandice L.; Rasmussen, Astrid; Aghakhanian, Farhang; Reksten, Tove Ragna; Adler, Adam; Alevizos, Ilias; Anaya, Juan-Manuel; Aqrawi, Lara A.; Baecklund, Eva; Brun, Johan Gorgas; Bucher, Sara Magnusson; Eloranta, Maija-Leena; Engelke, Fiona; Forsblad-d’Elia, Helena; Glenn, Stuart B.; Hammenfors, Daniel; Imgenberg-Kreuz, Juliana; Jensen, Janicke Liaaen; Johnsen, Svein Joar Auglæn; Jonsson, Malin Viktoria; Kvarnström, Marika; Kelly, Jennifer A.; Li, He; Mandl, Thomas; Martín, Javier; Nocturne, Gaétane; Norheim, Katrine Brække; Palm, Øyvind; Skarstein, Kathrine; Stolarczyk, Anna M.; Taylor, Kimberly E.; Teruel, Maria; Theander, Elke; Venuturupalli, Swamy; Wallace, Daniel J.; Grundahl, Kiely M.; Hefner, Kimberly S.; Radfar, Lida; Lewis, David M.; Stone, Donald U.; Kaufman, C. Erick; Brennan, Michael T.; Guthridge, Joel M.; James, Judith A.; Scofield, R. Hal; Gaffney, Patrick M.; Criswell, Lindsey A.; Jonsson, Roland; Eriksson, Per; Bowman, Simon J.; Omdal, Roald; Rönnblom, Lars; Warner, Blake; Rischmueller, Maureen; Witte, Torsten; Farris, A. Darise; Mariette, Xavier; Alarcon-Riquelme, Marta E.; Shiboski, Caroline H.; Herlenius, Marie Elisabeth Wahren; Ng, Wan-Fai; Sivils, Kathy L.; Adrianto, Indra; Nordmark, Gunnel; Lessard, Christopher J. (Journal article; Peer reviewed, 2022)

  Sjögren’s disease is a complex autoimmune disease with twelve established susceptibility loci. This genome-wide association study (GWAS) identifies ten novel genome-wide significant (GWS) regions in Sjögren’s cases of ...

• Multimarker profiling identifies protective and harmful immune processes in heart failure: Findings from BIOSTAT-CHF 

  Markousis-Mavrogenis, George; Tromp, Jasper; Ouwerkerk, Wouter; Ferreira, João Pedro; Anker, Stefan D; Cleland, John G; Dickstein, Kenneth; Filippatos, Gerasimos; Lang, Chim C; Metra, Marco; Samani, Nilesh J; De Boer, Rudolf A; Van Veldhuisen, Dirk J; Voors, Adriaan A; Van Der Meer, Peter (Journal article; Peer reviewed, 2022)

  Aims The exploration of novel immunomodulatory interventions to improve outcome in heart failure (HF) is hampered by the complexity/redundancies of inflammatory pathways, which remain poorly understood. We thus aimed to ...

• Shared etiology of type 1 diabetes and Hashimoto’s thyroiditis: a population-based twin study 

  Skov, Jakob; Kuja-Halkola, Ralf; Magnusson, Patrik K.E.; Gudbjörnsdottir, Soffia; Kämpe, Olle; Bensing, Sophie (Journal article; Peer reviewed, 2022)

  Objective Type 1 diabetes and Hashimoto’s thyroiditis frequently cluster in individuals and in families, indicating shared origins. The objective of this study was to investigate familial co-aggregation of these diseases ...

• Humanized Ovarian Cancer Patient-Derived Xenografts for Improved Preclinical Evaluation of Immunotherapies 

  Kleinmanns, Katrin; Gullaksen, Stein-Erik; Bredholt, Geir; Davidson, Ben; Torkildsen, Cecilie Fredvik; Grindheim, Sindre; Bjørge, Line; Cormack, Emmet Mc (Journal article; Peer reviewed, 2022)

  High-grade serous ovarian cancer (HGSOC) has poor prognosis and new treatment modalities are needed. Immunotherapy, with checkpoint inhibitors, have demonstrated limited impact. To evaluate the suitability for immunotherapeutics, ...

• Imaging of Clear Cell Renal Carcinoma with Immune Checkpoint Targeting Aptamer-Based Probe 

  Malicki, Stanisław; Pucelik, Barbara; Żyła, Edyta; Benedyk-Machaczka, Małgorzata; Gałan, Wojciech; Golda, Anna; Sochaj-Gregorczyk, Alicja; Kaminska, Marta; Encarnação, João Crispim; Chruścicka, Barbara; Marti, Hans Peter; Chen, Tony Jialiang; Magiera-Mularz, Katarzyna; Zięba, Bartosz; Holak, Tad A.; Dabrowski, Janusz M.; Czarna, Anna; Kozieł, Joanna; Mydel, Piotr Mateusz; Dubin, Grzegorz (Journal article; Peer reviewed, 2022-06-01)

  Immune checkpoint targeting immunotherapy has revolutionized the treatment of certain cancers in the recent years. Determination of the status of immune checkpoint expression in particular cancers may assist decision making. ...

• Pretransplant Systemic Lipidomic Profiles in Allogeneic Stem Cell Transplant Recipients 

  Hatfield, Kimberley Joanne; Bruserud, Øystein; Reikvam, Håkon (Journal article; Peer reviewed, 2022-06-13)

  Allogeneic stem cell transplantation is used in the treatment of high-risk hematological malignancies. However, this treatment is associated with severe treatment-related morbidity and mortality. The metabolic status of ...

• NPM1-Mutated Patient-Derived AML Cells Are More Vulnerable to Rac1 Inhibition 

  Hemsing, Anette Lodvir; Rye, Kristin Paulsen; Hatfield, Kimberley Joanne; Reikvam, Håkon (Journal article; Peer reviewed, 2022)

  The prognosis of acute myeloid leukemia (AML) is poor, especially for the elderly population. Targeted therapy with small molecules may be a potential strategy to overcome chemoresistance and improve survival in AML. We ...

• Premature menopause and autoimmune primary ovarian insufficiency in two international multi-center cohorts 

  Vogt, Elinor Margrethe Chelsom; Real, Francisco Gomez; Husebye, Eystein Sverre; Björnsdottir, Sigridur; Benediktsdottir, Bryndis; Bertelsen, Randi Jacobsen; Demoly, Pascal; Franklin, Karl Anders; Gallastegui, Leire Sainz de Aja; González, Francisco Javier Callejas; Heinrich, Joachim; Holm, Mathias; Jögi, Nils Oskar; Leynaert, Benedicte; Lindberg, Eva; Malinovschi, Andrei; Martínez-Moratalla, Jesús; Mayoral, Raúl Godoy; Oudin, Anna; Pereira-Vega, Antonio; Semjen, Chantal Raherison; Schlünssen, Vivi; Triebner, Kai Philipp; Øksnes, Marianne (Journal article; Peer reviewed, 2022)

  Objective To investigate markers of premature menopause (<40 years) and specifically the prevalence of autoimmune primary ovarian insufficiency (POI) in European women. Design Postmenopausal women were categorized ...

• Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway 

  Helland, Åslaug; Russnes, Hege Elisabeth Giercksky; Fagereng, Gro Live; Al-Shibli, Khalid Ibrahim; Andersson, Yvonne; Berg, Thomas; Bjørge, Line; Blix, Egil Støre; Bjerkehagen, Bodil; Brabrand, Sigmund; Dalhaug, Astrid; Dietzel, Dalia; Dønnem, Tom; Enerly, Espen; Flobak, Åsmund; Fluge, Sverre; Gilje, Bjørnar; Gjertsen, Bjørn Tore; Grønberg, Bjørn Henning; Grønås, Kari; Guren, Tormod Kyrre; Hamre, Hanne Mari; Haug, Åse; Heinrich, Daniel; Hjortland, Geir Olav; Hovig, Eivind; Hovland, Randi; Iversen, Ann-Charlotte; Janssen, Emiel; Kyte, Jon A; Gythfeldt, Hedda; Lothe, Ragnhild Adelheid; Lund, Jo-Åsmund; Meza, Leonardo Zepeda; Munthe-Kaas, Monica Cheng; Nguyen, Olav Toai Duc; Niehusmann, Pitt; Nilsen, Hilde; Puco, Katarina; Ree, Anne Hansen; Riste, Tonje Bøyum; Semb, Karin; Steinskog, Eli Sihn Samdal; Stensvold, Andreas; Suhrke, Pål; Tennøe, Øyvind Krohn; Tjønnfjord, Geir Erland; Vassbotn, Liv Jorunn; Aas, Eline; Aasebø, Kristine Øverås; Tasken, Kjetil; Smeland, Sigbjørn; Cameron, Marte Grønlie (Journal article; Peer reviewed, 2022)

  Background Matching treatment based on tumour molecular characteristics has revolutionized the treatment of some cancers and has given hope to many patients. Although personalized cancer care is an old concept, renewed ...

• Immune marker levels in severe mental disorders: associations with polygenic risk scores of related mental phenotypes and psoriasis 

  Werner, Maren Caroline Frogner; Wirgenes, Katrine Verena; Shadrin, Alexey; Lunding, Synve Hoffart; Rødevand, Linn; Hjell, Gabriela; Ormerod, Monica Bettina E. Greenwood; Haram, Marit; Agartz, Ingrid; Djurovic, Srdjan; Melle, Ingrid; Aukrust, Pål; Ueland, Thor; Andreassen, Ole; Steen, Nils Eiel (Journal article; Peer reviewed, 2022)

  Several lines of evidence implicate immune abnormalities in the pathophysiology of severe mental disorders (SMD) and comorbid mental disorders. Here, we use the data from genome-wide association studies (GWAS) of autoimmune ...

• Corticosteroids and superinfections in COVID-19 patients on invasive mechanical ventilation 

  Søvik, Signe; Barrat-Due, Andreas; Kåsine, Trine; Olasveengen, Theresa M.; Strand, Marianne Wigernes; Tveita, Anders Aune; Berdal, Jan-Erik; Lehre, Martin Andreas; Lorentsen, Torleif; Heggelund, Lars; Stenstad, Tore; Ringstad, Jetmund; Müller, Fredrik; Aukrust, Pål; Holter, Jan Cato; Nordøy, Ingvild (Journal article; Peer reviewed, 2022)

  Objectives To determine the incidence and characteristics of superinfections in mechanically ventilated COVID-19 patients, and the impact of dexamethasone as standard therapy. Methods This multicentre, observational, ...

• Sepsis and antibiotic exposure in the neonatal period 

  Vatne, Anlaug (Doctoral thesis, 2022-09-30)

  Bakgrunn: Neonatalperioden (første 28 levedager) er den perioden i livet med høyest risiko for å utvikle sepsis. Tidlig nyfødt-sepsis (oppvekst i blodkultur innen første tre levedager) er assosiert med høy morbiditet og ...

• Distinct pathophysiological pathways in women and men with heart failure 

  Ravera, Alice; Santema, Bernadet T.; de Boer, Rudolf A.; Anker, Stefan D.; Samani, Nilesh J.; Lang, Chim C.; Ng, Leong; Cleland, John G.F.; Dickstein, Kenneth; Lam, Carolyn S.P.; Van Spall, Harriette G. C.; Filippatos, Gerasimos; van Veldhuisen, Dirk J.; Metra, Marco; Voors, Adriaan A.; Sama, Iziah E. (Journal article; Peer reviewed, 2022)

  Aims: Clinical differences between women and men have been described in heart failure (HF). However, less is known about the underlying pathophysiological mechanisms. In this study, we compared multiple circulating biomarkers ...

• Effects of sildenafil on symptoms and exercise capacity for heart failure with reduced ejection fraction and pulmonary hypertension (the SilHF study): a randomized placebo-controlled multicentre trial 

  Cooper, Trond Johan; Cleland, John G.F.; Guazzi, Marco; Pellicori, Pierpaolo; Ben Gal, Tuvia; Amir, Offer; Al-Mohammad, Abdallah; Clark, Andrew L.; McConnachie, Alex; Steine, Kjetil; Dickstein, Kenneth (Journal article; Peer reviewed, 2022)

  Aims: Pulmonary hypertension (PHT) may complicate heart failure with reduced ejection fraction (HFrEF) and is associated with a substantial symptom burden and poor prognosis. Sildenafil, a phosphodiesterase-5 (PDE-5) ...

• Composite immune marker scores associated with severe mental disorders and illness course 

  Ormerod, Monica Bettina E. Greenwood; Ueland, Thor; Werner, Maren Caroline Frogner; Hjell, Gabriela; Rødevand, Linn Nilsen; Sæther, Linn Sofie; Lunding, Synve Hoffart; Johansen, Ingrid Torp; Ueland, Torill; Lagerberg, Trine Vik; Melle, Ingrid; Djurovic, Srdjan; Andreassen, Ole; Steen, Nils Eiel (Journal article; Peer reviewed, 2022)

  Background Low-grade inflammation has been implicated in the pathophysiology of severe mental disorders (SMDs) and a link between immune activation and clinical characteristics is suggested. However, few studies have ...

• The course and determinants of post-traumatic stress over 12 months after hospitalization for COVID-19 

  Stavem, Knut; Heir, Trond; Dammen, Toril; Brønstad, Eivind; Lerum, Tøri Vigeland; Durheim, Michael Thomas; Lund, Kristine Marie Aarberg; Aarli, Bernt Bøgvald; Einvik, Gunnar (Journal article; Peer reviewed, 2022)

  Objective: To assess the trajectory of symptoms and symptom-defined post-traumatic stress disorder (PTSD) from 1.5 to 12 months after hospitalization for COVID-19 and determine risk factors for persistent symptoms and ...

• Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects 

  Howe, Laurence J.; Nivard, Michel G.; Morris, Tim T.; Hansen, Ailin Falkmo; Rasheed, Humaira; Cho, Yoonsu; Chittoor, Geetha; Ahlskog, Rafael; Lind, Penelope A.; Palviainen, Teemu; van der Zee, Matthijs D.; Cheesman, Rosa Catherine Gillespie; Mangino, Massimo; Wang, Yunzhang; Li, Shuai; Klaric, Lucija; Ratliff, Scott M.; Bielak, Lawrence F.; Nygaard, Marianne; Giannelis, Alexandros; Willoughby, Emily A.; Reynolds, Chandra A.; Balbona, Jared V.; Andreassen, Ole; Ask, Helga; Baras, Aris; Bauer, Christopher R.; Boomsma, Dorret I.; Campbell, Archie; Campbell, Harry; Chen, Zhengming; Christofidou, Paraskevi; Corfield, Elizabeth Claire; Dahm, Christina C.; Dokuru, Deepika R.; Evans, Luke M.; de Geus, Eco J. C.; Giddaluru, Sudheer; Gordon, Scott D.; Harden, K. Paige; Hill, W. David; Hughes, Amanda; Kerr, Shona M.; Kim, Yongkang; Kweon, Hyeokmoon; Latvala, Antti; Lawlor, Deborah A.; Li, Liming; Lin, Kuang; Magnus, Per Minor; Magnusson, Patrik K. E.; Mallard, Travis T.; Martikainen, Pekka; Mills, Melinda C.; Njølstad, Pål Rasmus; Overton, John D.; Pedersen, Nancy L.; Porteous, David J.; Reid, Jeffrey; Silventoinen, Karri; Southey, Melissa C.; Stoltenberg, Camilla; Tucker-Drob, Elliot M.; Wright, Margaret J.; Kweon, Hyeokmoon; Koellinger, Philipp D.; Benjamin, Daniel J.; Turley, Patrick; Howe, Laurence J.; Nivard, Michel G.; Morris, Tim T.; Plomin, Robert; Havdahl, Alexandra; Bartels, Meike; Martin, Nicholas G.; Oskarsson, Sven; Justice, Anne E.; Millwood, Iona Y.; Hveem, Kristian; Naess, Øyvind; Willer, Cristen J.; Åsvold, Bjørn Olav; Kaprio, Jaakko; Medland, Sarah E.; Walters, Robin G.; Evans, David M.; Smith, George Davey; Hayward, Caroline; Brumpton, Ben; Hemani, Gibran; Davies, Neil Martin; Hewitt, John K.; Keller, Matthew C.; Stallings, Michael C.; Lee, James J.; Christensen, Kaare; Kardia, Sharon L. R.; Peyser, Patricia A.; Smith, Jennifer A.; Wilson, James F.; Hopper, John L.; Hägg, Sara; Spector, Tim D.; Pingault, Jean-Baptiste; Næss, Øyvind Erik; Davey Smith, George; Brumpton, Ben Michael (Journal article; Peer reviewed, 2022)

  Estimates from genome-wide association studies (GWAS) of unrelated individuals capture effects of inherited variation (direct effects), demography (population stratification, assortative mating) and relatives (indirect ...

• Boosting Schizophrenia Genetics by Utilizing Genetic Overlap With Brain Morphology 

  van der Meer, Dennis; Shadrin, Alexey; O'Connell, Kevin Sean; Bettella, Francesco; Djurovic, Srdjan; Wolfers, Thomas; Alnæs, Dag; Agartz, Ingrid; Smeland, Olav Bjerkehagen; Melle, Ingrid; Sánchez, Jennifer Monereo; Linden, David E.J.; Dale, Anders; Westlye, Lars Tjelta; Andreassen, Ole; Frei, Oleksandr; Kaufmann, Tobias (Journal article; Peer reviewed, 2022)

  Background Schizophrenia is a complex polygenic disorder with subtle, distributed abnormalities in brain morphology. There are indications of shared genetic architecture between schizophrenia and brain measures despite ...

• Helminth exposure and its association with allergies and lung function in Northern European cohorts 

  Jögi, Nils Oskar (Doctoral thesis, 2022-09-19)

  Bakgrunn: De siste tiårene har forekomsten av astma og allergi økt over hele verden. I land hvor parasittinfeksjoner er endemiske, er forekomsten av astma og allergi lavere enn i land med lavere forekomst av parasitter. ...

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