• Near-Infrared Fluorescent Imaging for Monitoring of Treatment Response in Endometrial Carcinoma Patient-Derived Xenograft Models. 

  Fonnes, Tina; Strand, Elin; Fasmer, Kristine Eldevik; Berg, Hege Fredriksen; Espedal, Heidi; Sortland, Kristina; Stefansson, Ingunn; Bjørge, Line; Haldorsen, Ingfrid S; Krakstad, Camilla; Mc Cormack, Emmet (Journal article; Peer reviewed, 2020)

  Imaging of clinically relevant preclinical animal models is critical to the development of personalized therapeutic strategies for endometrial carcinoma. Although orthotopic patient-derived xenografts (PDXs) reflecting ...

• A Pilot Study of Circulating Monocyte Subsets in Patients Treated with Stem Cell Transplantation for High-Risk Hematological Malignancies. 

  Rundgren, Ida Marie; Ersvær, Elisabeth; Ahmed, Aymen B; Bruserud, Øystein; Ryningen, Anita (Journal article; Peer reviewed, 2020)

  Background and Objectives: Autologous and allogeneic stem cell transplantation is used in the treatment of high-risk hematological malignancies, and monocytes are probably involved in hematological reconstitution as well ...

• Environmental pollutants in blood donors: The multicentre Norwegian donor study 

  Averina, Maria; Hervig, Tor; Huber, Sandra; Kjær, Mette; Kristoffersen, Einar Klæboe; Bolann, Bjørn Johan (Journal article; Peer reviewed, 2020)

  Objectives The aim of this study was to measure blood concentrations of environmental pollutants in Norwegian donors and evaluate the risk of pollutant exposure through blood transfusions. Background Transfused blood ...

• Unsupervised clustering of missense variants in HNF1A using multidimensional functional data aids clinical interpretation 

  Althari, Sara; Najmi, Laeya Abdoli; Bennett, Amanda J.; Aukrust, Ingvild; Rundle, Jana K.; Colclough, Kevin; Molnes, Janne; Kaci, Alba; Nawaz, Sameena; van der Lugt, Timme; Hassanali, Neelam; Mahajan, Anubha; Molven, Anders; Ellard, Sian; McCarthy, Mark I.; Bjørkhaug, Lise; Njølstad, Pål Rasmus; Gloyn, Anna L. (Journal article; Peer reviewed, 2020-10-01)

  Exome sequencing in diabetes presents a diagnostic challenge because depending on frequency, functional impact, and genomic and environmental contexts, HNF1A variants can cause maturity-onset diabetes of the young (MODY), ...

• High-Sensitivity Cardiac Troponin I and T Response Following Strenuous Activity is Attenuated by Smokeless Tobacco: NEEDED (North Sea Race Endurance Exercise Study) 2014 

  Skranes, Julia Brox; Kleiven, Øyunn; Aakre, Kristin Moberg; Skadberg, Øyvind; Melberg, Tor Harald; Omland, Torbjørn; Ørn, Stein (Journal article; Peer reviewed, 2020)

  Background Use of snus, a smokeless tobacco product, is increasing in Scandinavia. Strenuous physical activity is associated with an acute increase in high‐sensitivity cardiac troponin (swhs‐cTn) concentrations. Current ...

• Long-term effect of cognitive–behavioural therapy in patients with Hypochondriacal Disorder 

  Veddegjærde, Kari-Elise Frøystad; Sivertsen, Børge; Skogen, Jens Christoffer; Smith, Otto Robert Frans; Wilhelmsen, Ingvard (Journal article; Peer reviewed, 2020)

  Background Cognitive–behavioural therapy (CBT) is an effective treatment for Hypochondriacal Disorder, but the long-term effect has not been examined extensively. Aims To investigate the long-term effect of CBT on ...

• The PI3K-Akt-mTOR signaling pathway in human acute myeloid leukemia (AML) cells 

  Nepstad, Ina; Hatfield, Kimberley Joanne; Grønningsæter, Ida Sofie; Reikvam, Håkon (Journal article; Peer reviewed, 2020)

  Acute myeloid leukemia (AML) is a heterogeneous group of diseases characterized by uncontrolled proliferation of hematopoietic stem cells in the bone marrow. Malignant cell growth is characterized by disruption of normal ...

• Inhibition of NF-κB signaling alters acute myelogenous leukemia cell transcriptomics 

  Reikvam, Håkon (Journal article; Peer reviewed, 2020)

  Acute myelogenous leukemia (AML) is an aggressive hematological malignancy. The pathophysiology of the disease depends on cytogenetic abnormalities, gene mutations, aberrant gene expressions, and altered epigenetic regulation. ...

• Surgical Treatment of Severe Bowel Obstruction as a Rare Complication Following Allogenic Hematopoietic Stem Cell Transplantation 

  Reikvam, Håkon; Tvedt, Tor Henrik Anderson; Johansen, Silje; Setran, Hege Aase; Havre, Roald Flesland (Journal article, 2020)

  Gastrointestinal graft-versus-host disease (GVHD) and cytomegalovirus (CMV) disease are common complications occurring after allogeneic hematopoietic stem cell transplantation (allo-HSCT), and contribute to a high degree ...

• The Biological Context of C-Reactive Protein as a Prognostic Marker in Renal Cell Carcinoma: Studies on the Acute Phase Cytokine Profile 

  Aarstad, Helene Hersvik; Gudbrandsdottir, Gigja; Hjelle, Karin; Bostad, Leif; Bruserud, Øystein; Tvedt, Tor Henrik Anderson; Beisland, Christian (Journal article; Peer reviewed, 2020)

  High serum levels of the acute phase protein C-reactive protein (CRP) are associated with an adverse prognosis in renal cancer. The acute phase reaction is cytokine-driven and includes a wide range of inflammatory mediators. ...

• Multimodal imaging of thyroid cancer 

  Brauckhoff, Katrin; Biermann, Martin (Journal article, 2020)

  Purpose of review Thyroid cancer is the most common endocrine cancer in adults with rising incidence. Challenges in imaging thyroid cancer are twofold: distinguishing thyroid cancer from benign thyroid nodules, which ...

• Single cell signalling and immune cell profiling in psoriasis 

  Aarebrot, Anders Krogh (Doctoral thesis, 2021-02-19)

  Psoriasis is a common, chronic inflammatory skin disease with associated autoantigens, autoantibodies, local and systemic inflammation, and systemic comorbidities, such as cardiovascular disease and metabolic syndrome. ...

• Circulating monocyte subsets in multiple myeloma patients receiving autologous stem cell transplantation – a study of the preconditioning status and the course until posttransplant reconstitution for a consecutive group of patients 

  Rundgren, Ida Marie; Ersvær, Elisabeth; Ahmed, Aymen B; Ryningen, Anita; Bruserud, Øystein (Journal article, 2019)

  Background Induction therapy of multiple myeloma patients prior to autologous stem cell transplantation has changed from conventional chemotherapy to treatment based on proteasome inhibitors or immunomodulatory drugs. We ...

• Self-esteem in patients with inflammatory bowel disease 

  Opheim, Randi; Moum, Bjørn; Jahnsen, Jørgen; Berset, Ingrid Prytz; Hovde, Øistein; Huppertz-Hauss, Gert; Bernklev, Tomm; Jelsness-Jørgensen, Lars-Petter; Grimstad, Bjørn Tore (Journal article; Peer reviewed, 2020)

  Purpose: The purpose of this study was to explore self-esteem and associations between self-esteem and sociodemographic, clinical, and psychological factors in patients with inflammatory bowel disease (IBD), a disease ...

• Assessment of tumor suppressor promoter methylation in healthy individuals 

  Poduval, Deepak; Berge, Elisabet Ognedal; Sichmanovà, Zuzana; Valen, Eivind; Iversen, Gjertrud Titlestad; Minsaas, Laura; Lønning, Per Eystein; Knappskog, Stian (Journal article; Peer reviewed, 2020-08)

  Background The number of tumor suppressor genes for which germline mutations have been linked to cancer risk is steadily increasing. However, while recent reports have linked constitutional normal tissue promoter methylation ...

• Identifying targets for antibiotic stewardship interventions through analysis of the antibiotic prescribing process in hospitals - a multicentre observational cohort study 

  Wathne, Jannicke Slettli; Skodvin, Brita; Charani, Esmita; Harthug, Stig; Blix, Hege Salvesen; Nilsen, Roy Miodini; Kleppe, Lars Kåre Selland; Vukovic, Marta; Smith, Ingrid (Journal article; Peer reviewed, 2020)

  Background: In order to change antibiotic prescribing behaviour, we need to understand the prescribing process. The aim of this study was to identify targets for antibiotic stewardship interventions in hospitals through ...

• In vivo environment swiftly restricts human pancreatic progenitors toward mono-hormonal identity via a HNF1A/HNF4A mechanism 

  Legøy, Thomas Aga; Mathisen, Andreas Frøslev; Salim, Zaidon; Vethe, Heidrun; Bjørlykke, Yngvild; Abadpour, Shadab; Paulo, Joao; Scholz, Hanne; Ræder, Helge; Ghila, Luiza; Chera, Simona (Journal article; Peer reviewed, 2020)

  Generating insulin-producing β-cells from human induced pluripotent stem cells is a promising cell replacement therapy for improving or curing insulin-dependent diabetes. The transplantation of end-stages differentiating ...

• Beyond sleep duration: Sleep timing as a risk factor for childhood obesity 

  Skjåkødegård, Hanna Flækøy; Danielsen, Yngvild Sørebø; Frisk, Bente; Hystad, Sigurd William; Roelants, Mathieu; Pallesen, Ståle; Conlon, Rachel; Wilfley, Denise E.; Juliusson, Petur Benedikt (Journal article; Peer reviewed, 2021)

  Background: Ample evidence attests to the relationship between short sleep duration, sleep problems and childhood obesity. However, few studies have examined the association between sleep timing and obesity in ...

• Granulocyte colony-stimulating factor alters the systemic metabolomic profile in healthy donors 

  Hatfield, Kimberley Joanne; Melve, Guro Kristin; Bruserud, Øystein (Journal article; Peer reviewed, 2017)

  Introduction: Peripheral blood stem cells mobilized by granulocyte colony-stimulating factor (G-CSF) from healthy donors are commonly used for allogeneic stem cell transplantation. The effect of G-CSF administration on ...

• Monocyte-derived dendritic cells in cancer immunotherapy : Considerations on their applicability 

  Yi, Dag Heiro (Doctoral thesis, 2021-02-17)

  Cancer is the leading cause of death in the developed world. While treatment options and detection have improved over the last century, mortality rate remains high especially in metastatic disease. Traditional treatment ...

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