• The mycobiome in COPD: Descriptive and longitudinal analysis, and participation in research bronchoscopy studies 

  Martinsen, Einar Marius Hjellestad (Doctoral thesis, 2021-06-25)

  Background: Chronic obstructive pulmonary disease (COPD) is a high-prevalent lung disease with high mortality rates. The COPD pathogenesis is only partly understood, and we do not know why some risk factor exposed subjects ...

• The pulmonary mycobiome—A study of subjects with and without chronic obstructive pulmonary disease 

  Martinsen, Einar Marius Hjellestad; Eagan, Tomas Mikal Lind; Leiten, Elise Orvedal; Haaland, Ingvild; Husebø, Gunnar Reksten; Knudsen, Kristel Svalland; Drengenes, Christine; Sanseverino, Walter; Paytuví-Gallart, Andreu; Nielsen, Rune (Journal article; Peer reviewed, 2021-04-07)

  Background: The fungal part of the pulmonary microbiome (mycobiome) is understudied. We report the composition of the oral and pulmonary mycobiome in participants with COPD compared to controls in a large-scale single-centre ...

• Preclinical molecular imaging in oncology – From chemical synthesis to clinical translatable applications 

  García de Jalón Viñegra, Elvira (Doctoral thesis, 2021-06-25)

  Background: Molecular imaging (MI) is fundamental in clinical settings for diagnosis, treatment selection, intraoperative guidance and treatment efficacy evaluation. This field has progressed rapidly in recent years, driven ...

• Improving response to progestin treatment of low-grade endometrial cancer 

  Baxter, Eva; Brennan, Donal J.; McAlpine, Jessica N.; Mueller, Jennifer J.; Amant, Frédéric; van Gent, Mignon D.J.M.; Huntsman, David G.; Coleman, Robert L.; Westin, Shannon N.; Yates, Melinda S.; Krakstad, Camilla; Quinn, Michael; Janda, Monika; Obermair, Andreas (Journal article; Peer reviewed, 2020)

  Objectives This review examines how response rates to progestin treatment of low-grade endometrial cancer can be improved. In addition to providing a brief overview of the pathogenesis of low-grade endometrial cancer, ...

• Reduced delays in diagnostic pathways for non-small cell lung cancer after local and National initiatives 

  Lærum, Dan; Brustugun, Odd Terje; Gallefoss, Frode; Falk, Ragnhild Sørum; Strand, Trond-Eirik; Fjellbirkeland, Lars (Journal article; Peer reviewed, 2020)

  Objectives Patients with non-small cell lung cancer (NSCLC) may experience progression and stage shift due to delays in a complex and time-consuming diagnostic work-up. We have analyzed the impact of both a local and ...

• Ancestrally Duplicated Conserved Noncoding Element Suggests Dual Regulatory Roles of HOTAIR in cis and trans 

  Nepal, Chirag; Taranta, Andrzej; Hadzhiev, Yavor; Pundhir, Sachin; Mydel, Piotr Mateusz; Lenhard, Boris; Müller, Ferenc; Andersen, Jesper B. (Journal article; Peer reviewed, 2020-04)

  HOTAIR was proposed to regulate either HoxD cluster genes in trans or HoxC cluster genes in cis, a mechanism that remains unclear. We have identified a 32-nucleotide conserved noncoding element (CNE) as HOTAIR ancient ...

• Accurate 3-gene-signature for early diagnosis of liposarcoma progression 

  Serguienko, Anastassia; Braadland, Peder Rustøen; Meza-Zepeda, Leonardo A.; Bjerkehagen, Bodil; Myklebost, Ola (Journal article; Peer reviewed, 2020)

  Background Well- and dedifferentiated liposarcoma (WD/DDLPS) are rare mesenchymal malignant tumors that account for 20% of all sarcomas in adults. The WD form is a low-grade malignancy with a favourable prognosis which ...

• Molecular characterization of a large unselected cohort of metastatic colorectal cancers in relation to primary tumor location, rare metastatic sites and prognosis 

  Nunes, Luís; Aasebø, Kristine; Mathot, Lucy; Ljungström, Viktor; Edqvist, Per-Henrik; Sundström, Magnus; Dragomir, Anca; Pfeiffer, Per; Ameur, Adam; Pontén, Fredrik; Mezheyeuski, Artur; Sorbye, Halfdan; Sjöblom, Tobias; Glimelius, Bengt (Journal article; Peer reviewed, 2020-01-10)

  Background: We have reported that BRAF V600E mutations and microsatellite instability-high (MSI-H) are more prevalent in a population-based cohort of metastatic colorectal cancer (mCRC) patients than has been reported from ...

• The kynurenine pathway in cognition, dementia, and aging 

  Solvang, Stein-Erik Hafstad (Doctoral thesis, 2021-06-16)

  Background: Experimental studies implicate the kynurenine pathway in cognitive function, dementia, aging, and longevity. Comparatively, clinical studies are few and most lack comprehensive targeted metabolomic profiling ...

• Second-line and Third-line therapy for Autoimmune Hepatitis: A position statement from the European Reference Network on Hepatological Diseases and the International Autoimmune Hepatitis Group 

  Lohse, Ansgar W.; Sebode, Marcial; Jørgensen, Marianne H.; Ytting, Henriette; Karlsen, Tom Hemming; Kelly, Deirdre; Manns, Michael P.; Vesterhus, Mette (Journal article; Peer reviewed, 2020)

  Most patients with autoimmune hepatitis respond well to standard immunosuppressive therapy with steroids and azathioprine, and while untreated disease is usually fatal, patients who respond well to therapy have an excellent ...

• Detection of remaining Plasmodium DNA and gametocytes during follow up after curative malaria treatment among returned travellers in Norway 

  Haanshuus, Christel Gill; Mørch, Kristine (Journal article; Peer reviewed, 2020)

  Background PCR can be positive weeks after effective malaria treatment, potentially leading to over diagnose of recrudescence and re-infections. The DNA detected by PCR post-treatment might stem from residuals of destroyed ...

• Circulating trimethyllysine and risk of acute myocardial infarction in patients with suspected stable coronary heart disease 

  Bjørnestad, Espen Ø.; Olset, Hilde; Dhar, Indu; Løland, Kjetil Halvorsen; Pedersen, Eva Ringdal; Svingen, Gard Frodahl Tveitevåg; Svardal, Asbjørn M.; Berge, Rolf K; Ueland, Per Magne; Tell, Grethe S.; Nilsen, Dennis W.T.; Jan E., Nordrehaug; Nygaard, Ellisif; Nygård, Ottar (Journal article; Peer reviewed, 2020)

  Background The carnitine precursor trimethyllysine (TML) is associated with progression of atherosclerosis, possibly through a relationship with trimethylamine-N-oxide (TMAO). Riboflavin is a cofactor in TMAO synthesis. ...

• Half of children with recurrent or chronic wet cough before three years of age were symptom-free by age seven 

  Sørensen, Karen Galta; Mikalsen, Ingvild Bruun; Neven, Axel; Øymar, Knut (Journal article; Peer reviewed, 2020)

  Aim We aimed to study the natural course of recurrent episodic and chronic wet cough in preschool children, the proportion and age of resolution, and risk factors for persistent symptoms. Methods Parents of children ...

• High rate of antimicrobial resistance and multiple mutations in the dihydrofolate reductase gene among Streptococcus pneumoniae isolated from HIV-infected adults in a community setting in Tanzania 

  Manyahi, Joel; Moyo, Sabrina John; Aboud, Said; Langeland, Nina; Blomberg, Bjørn (Journal article; Peer reviewed, 2020)

  Objectives The aim of this study was to characterize molecular mechanisms of resistance to trimethoprim and other antibiotics in Streptococcus pneumoniae isolates from HIV-infected adults in Dar es Salaam, Tanzania. Methods A ...

• Acute exacerbations of COPD and risk of lung cancer in COPD patients with and without a history of asthma 

  Gagnat, Ane Aamli; Gjerdevik, Miriam; Lie, Stein Atle; Gulsvik, Amund; Bakke, Per S.; Nielsen, Rune (Journal article; Peer reviewed, 2020)

  Rationale There is limited knowledge on the effect of acute exacerbations in chronic obstructive pulmonary disease (AECOPD) on lung cancer risk in COPD patients with and without a history of asthma. This study aims to ...

• Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults 

  Hofer, Edith; Roshchupkin, Gennady V.; Adams, Hieab H H; Knol, Maria J.; Lin, Honghuang; Li, Shuo; Zare, Habil; Ahmad, Shahzad; Armstrong, Nicola J.; Satizabal, Claudia L.; Panizzon, Matthew S.; Andreassen, Ole Andreas; Dale, Anders M.; Logue, Mark; Grasby, Katrina L.; Van Duijn, Cornelia M.; Grabe, Hans J.; Longstreth, William T.; Fornage, Myriam; Paus, Tomas; Debette, Stephanie; Ikram, M. Arfan; Schmidt, Helena; Schmidt, Reinhold; Seshadri, Sudha; Agartz, Ingrid; Alhusaini, Saud; Almeida, Marcio A.A.; Alnæs, Dag; Amlien, Inge Kasbohm; Doan, Nhat Trung; Gurholt, Tiril Pedersen; Kaufmann, Tobias; Richard, Geneviève; Sønderby, Ida Elken; van der Meer, Dennis; Wang, Yunpeng; Westlye, Lars Tjelta; Brandt, Christine Lycke; Djurovic, Srdjan; Kolskår, Knut-Kristian; Melle, Ingrid; Nordvik, Jan Egil; Steen, Vidar Martin; Espeseth, Thomas; Håberg, Asta; Wright, Margaret J.; Zhou, Juan; Stein, Jason L.; Thompson, Paul M.; Medland, Sarah E. (Journal article; Peer reviewed, 2020)

  Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these ...

• Cholesterol crystals and NLRP3 mediated inflammation in the uterine wall decidua in normal and preeclamptic pregnancies 

  Silva, Gabriela; Gierman, Lobke; Rakner, Johanne Johnsen; Stødle, Guro; Mundal, Siv Boon; Thaning, Astrid Josefin; Sporsheim, Bjørnar; Elschot, Mattijs; Collett, Karin; Bjørge, Line; Aune, Marie Hjelmseth; Thomsen, Liv Cecilie Vestrheim; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2020)

  Preeclampsia is a hypertensive and inflammatory pregnancy disorder associated with cholesterol accumulation and inflammation at the maternal-fetal interface. Preeclampsia can be complicated with fetal growth restriction ...

• COL6A3 expression in adipose tissue cells is associated with levels of the homeobox transcription factor PRRX1 

  Dankel, Simon N; Grytten, Elise; Bjune, Jan-Inge; Nielsen, Hans Jørgen; Dietrich, Arne; Blüher, Matthias; Sagen, Jørn V.; Mellgren, Gunnar (Journal article; Peer reviewed, 2020)

  Fibrillar collagen COL6α3 in adipose tissue has been associated with obesity, inflammation, insulin resistance and cancer. We here aimed to identify novel transcriptional regulators of COL6A3 expression. Based on a ...

• Systemic inflammatory markers as predictors of longitudinal outcomes in COPD : Results from the Bergen COPD Cohort Study 

  Husebø, Gunnar Reksten (Doctoral thesis, 2021-06-02)

  Background: Chronic obstructive pulmonary disease (COPD) is major cause of morbidity and mortality worldwide. The prevalence is increasing worldwide, as a result of an increase in cigarette smoking the last decades. The ...

• Early Induction of Cross-Reactive CD8+ T-Cell Responses in Tonsils After Live-Attenuated Influenza Vaccination in Children 

  Mohn, Kristin Greve Isdahl; Brokstad, Karl Albert; Islam, Shahinul; Oftung, Fredrik; Tøndel, Camilla; Aarstad, Hans Jørgen; Cox, Rebecca Jane (Journal article; Peer reviewed, 2020)

  Background Live-attenuated influenza vaccine (LAIV) was licensed for prophylaxis of children 2–17 years old in Europe in 2012 and is administered as a nasal spray. Live-attenuated influenza vaccine induces both mucosal ...

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