Department of Clinical Science: Recent submissions
Now showing items 1-20 of 2451
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Serum neurofilament light chain associates with symptom burden in Lyme neuroborreliosis patients: a longitudinal cohort study from Norway
(Journal article; Peer reviewed, 2024)Objectives: Serum neurofilament light chain (sNfL), an indicator of neuronal damage, is increasingly recognized as a potential biomarker for disease activity in neurodegenerative disorders. In this study, we wanted to ... -
Methodological Approaches to Experimental Evaluation of Neuroprotective Action of Potential Drugs
(Journal article; Peer reviewed, 2024-09-28)The authors propose a novel approach to a comprehensive evaluation of neuroprotective effects using both in vitro and in vivo methods. This approach allows for the initial screening of numerous newly synthesized chemical ... -
Sex effects on DNA methylation affect discovery in epigenome-wide association study of schizophrenia
(Journal article; Peer reviewed, 2024)Sex differences in the epidemiology and clinical characteristics of schizophrenia are well-known; however, the molecular mechanisms underlying these differences remain unclear. Further, the potential advantages of ... -
Taxonomic diversity and abundance of enchytraeids (Annelida, Clitellata, Enchytraeida) in the Northern Palaearctic. 1. Asian part
(Journal article; Peer reviewed, 2024)Background: Enchytraeids, or potworms, are tiny oligochaetes that are distributed worldwide in many terrestrial, freshwater and marine ecosystems. Despite their key role in the functioning of ecosystems, the diversity and ... -
Quantitative proteomics reveals serum proteome alterations during metastatic disease progression in breast cancer patients
(Journal article; Peer reviewed, 2024)Background Tumor recurrence and metastatic progression remains the leading cause for breast cancer related mortalities. However, the proteomes of patient- matched primary breast cancer (BC) and metastatic lesions have ... -
Increasing region of interest width reduces neonatal circumferential strain
(Journal article; Peer reviewed, 2024)Objective There is growing interest in speckle tracking echocardiography-derived strain as a measure of left ventricular function in neonates. However, knowledge gaps remain regarding the effect of image acquisition and ... -
Germline variants in patients diagnosed with pediatric soft tissue sarcoma
(Journal article; Peer reviewed, 2024)Background: While soft tissue sarcomas affect younger patients, few studies have assessed the distribution of underlying pathogenic germline variants. Patients and methods: We retrospectively identified all pediatric ... -
Decreased T-cell response against latent cytomegalovirus infection does not correlate with anti-IFN autoantibodies in patients with APECED
(Journal article; Peer reviewed, 2024)Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is an inborn error of immunity affecting both multiple endocrine organs and susceptibility to candidiasis, each with an autoimmune basis. Recently, ... -
Six-year follow-up of participants in two clinical trials of rituximab or cyclophosphamide in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
(Journal article; Peer reviewed, 2024)Objectives In this six-year follow-up study, we used patient-reported outcome measures (PROMs) to compare values at baseline, at 18 months, and at six-year follow up from the CycloME and the RituxME trials. Methods Based ... -
Quantified planar collagen distribution in healthy and degenerative mitral valve: biomechanical and clinical implications
(Journal article; Peer reviewed, 2024)Degenerative mitral valve disease is a common valvular disease with two arguably distinct phenotypes: fibroelastic deficiency and Barlow’s disease. These phenotypes significantly alter the microstructures of the leaflets, ... -
Expiratory airflow limitation in adults born extremely preterm: A systematic review and meta-analysis
(Journal article; Peer reviewed, 2024)Extreme preterm (EP) birth, denoting delivery before the onset of the third trimester, interrupts intrauterine development and causes significant early-life pulmonary trauma, thereby posing a lifelong risk to respiratory ... -
α1-Antichymotrypsin Complex (SERPINA3) Is an Independent Predictor of All-Cause but Not Cardiovascular Mortality in Patients Hospitalized for Chest Pain of Suspected Coronary Origin
(Journal article; Peer reviewed, 2024)Introduction: SERPINA3 is an acute phase protein triggered by inflammation. It is upregulated after an acute myocardial infarction (AMI). Data on its long-term prognostic value in MI patients are scarce. We aimed to assess ... -
Monocytic Differentiation in Acute Myeloid Leukemia Cells: Diagnostic Criteria, Biological Heterogeneity, Mitochondrial Metabolism, Resistance to and Induction by Targeted Therapies
(Journal article; Peer reviewed, 2024)We review the importance of monocytic differentiation and differentiation induction in non-APL (acute promyelocytic leukemia) variants of acute myeloid leukemia (AML), a malignancy characterized by proliferation of immature ... -
'When age is not a barrier': an explorative study of nonagenarian patients' experiences of undergoing percutaneous coronary intervention
(Journal article; Peer reviewed, 2024)Aims The recent rise in the number of nonagenarians (age ≥ 90 years) undergoing percutaneous coronary intervention (PCI) has revealed gaps in research, in particular on patients’ experiences. Therefore, the aim of the ... -
Time trends and birth rates in women with congenital heart disease; a nationwide cohort study from Norway 1994–2014
(Journal article; Peer reviewed, 2024)Background: More women with congenital heart disease (CHD) reach reproductive age, but little is known of their success in having children. We investigated time trends of CHD in women of reproductive age and maternal CHD ... -
Recurrent laryngeal nerve injury and nerve recovery evaluated by EMG, accelerometry and direct laryngoscopy : -An experimental approach -
(Doctoral thesis, 2024-12-13)Den mest fryktede komplikasjonen ved endokrinkirurgi på hals er bilateral skade på nervus laryngeus rekurrens (RLN) som kan føre til lammelse av stemmebåndene, ledsaget av alvorlige respirasjonsproblemer som kan ende i ... -
Lung function in Norway in the 20th century : Trends, lower limits of normality and overall and specific mortalities
(Doctoral thesis, 2024-12-06)Bakgrunn og mål: Lungefunksjon er en markør for generell helse og kan predikere mortalitet. Flere faktorer påvirker måling og tolkning av lungefunksjon i en befolkning. Målet med dette doktorgradsarbeidet var å studere den ... -
Preoperative risk factors associated with left ventricular dysfunction after bariatric surgery
(Journal article; Peer reviewed, 2024)A large proportion of patients with severe obesity remain with left ventricular (LV) dysfunction after bariatric surgery. We assessed whether preoperative evaluation by echocardiography and inflammatory proteins can identify ... -
Prognostic factors, treatment approach and clinical outcomes from glioblastoma: a population-based observational cohort study from Western Norway
(Doctoral thesis, 2024-12-06)Bakgrunn: Glioblastom er den vanligste og mest aggressive primære hjernesvulst hos voksne, og prognosen er svært alvorlig med median overlevelse på omtrent 15 måneder tross standard behandling med radiokjemoterapi. I klinisk ... -
Left ventricular mechanics and oxygen demand in patients with severe obesity undergoing Roux-en-Y gastric bypass surgery
(Doctoral thesis, 2024-11-29)Bakgrunn og mål: Venstre ventrikkel (VV) er eksponert for kronisk trykk- og volumoverbelastning ved alvorlig fedme. Effekten av vektreduserende kirurgi på fedme-relatert VV-dysfunksjon har ikke vært kartlagt i detalj ...