Browsing Department of Clinical Science by Title
Now showing items 1-20 of 1092
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0729. Interstitial changes in spleen during sepsis
(Conference object; Peer reviewed, 2014-09-26) -
Ability of a lean-seafood diet to modulate lipid and glucose metabolism in healthy humans – a randomized controlled trial with a crossover design
(Doctoral thesis, 2016-01-08)Background: A Westernised lifestyle, which involves a high-energy diet and reduced physical activity, is indisputably linked to the pandemics of obesity and type 2 diabetes. Prevention of cardiovascular disease and type 2 ... -
Absence of the proteoglycan decorin reduces glucose tolerance in overfed male mice
(Peer reviewed; Journal article, 2019)Studies have implicated the extracellular matrix (ECM) of adipose tissue in insulin resistance. The proteoglycan decorin, a component of ECM, has been associated with glucose tolerance, but possible causal effects on ... -
Abundant Genetic Overlap between Blood Lipids and Immune-Mediated Diseases Indicates Shared Molecular Genetic Mechanisms
(Peer reviewed; Journal article, 2015-04-08)Epidemiological studies suggest a relationship between blood lipids and immune-mediated diseases, but the nature of these associations is not well understood. We used genome-wide association studies (GWAS) to investigate ... -
Accuracy and usability of single-lead ECG from smartphones - A clinical study
(Peer reviewed; Journal article, 2019)Background: Several wireless ECG devices are commercially available for possible screening, monitoring and diagnosis of rhythms. The field is rapidly expanding, and some devices have demonstrated acceptable qualities. The ... -
Activated dendritic cells and monocytes in HIV immunological nonresponders: HIV-induced interferon-inducible protein-10 correlates with low future CD4+ recovery
(Peer reviewed; Journal article, 2019)Objective: To explore monocyte and dendritic cell immune responses, and their association with future CD4+ gain in treated HIV patients with suboptimal CD4+ recovery. Design: A cross-sectional study of HIV-infected, virally ... -
Activation of Akt characterizes estrogen receptor positive human breast cancers which respond to anthracyclines
(Peer reviewed; Journal article, 2017-04-17)Anthracyclines are key components of human breast cancer chemotherapy. Here, we explored the role of Akt signaling in anthracycline resistance. The antitumor activity of doxorubicin and Akt inhibitor A-443654 alone or ... -
The Active Tamoxifen Metabolite Endoxifen (4OHNDtam) Strongly Down-Regulates Cytokeratin 6 (CK6) in MCF-7 Breast Cancer Cells
(Peer reviewed; Journal article, 2015-04-13)Introduction: Tamoxifen is an anti-estrogen drug used in treatment of Estrogen Receptor (ER) positive breast cancer. Effects and side effects of tamoxifen is the sumof tamoxifen and all itsmetabolites. 4-Hydroxytamoxifen ... -
The activity of pregnancy-associated plasma protein A (PAPP-A) as expressed by immunohistochemistry in atherothrombotic plaques obtained by aspiration thrombectomy in patients presenting with a ST-elevation myocardial infarction: a brief communication
(Peer reviewed; Journal article, 2010-01-27)Background The expression of pregnancy-associated plasma protein A (PAPP-A) was identified by immunohistochemistry (IHC) in culprit atherothrombotic plaque specimens harvested from patients admitted with ST-segment elevation ... -
Acute bronchiolitis in infants, a review
(Peer reviewed; Journal article, 2014-04-03)Acute viral bronchiolitis is one of the most common medical emergency situations in infancy, and physicians caring for acutely ill children will regularly be faced with this condition. In this article we present a summary ... -
Adaptation and psychometric properties of the Norwegian version of the heart continuity of care questionnaire (HCCQ)
(Peer reviewed; Journal article, 2019-03-18)Background: Continuity of cardiac care after hospital discharge is a priority, especially as healthcare systems become increasingly complex and fragmented. There are few available instruments to measure continuity of cardiac ... -
Adaptive computerized working memory training in patients with mild cognitive impairment. A randomized double-blind active controlled trial
(Peer reviewed; Journal article, 2019-04-12)Objective: We investigated if a 5-week computerized adaptive working memory training program (Cogmed®) of 20 to 25 sessions would be effective in improving the working memory capacity and other neuropsychological functions ... -
Addition of IMP3 to L1CAM for discrimination between low- and high-grade endometrial carcinomas: a European Network for Individualised Treatment of Endometrial Cancer collaboration study
(Peer reviewed; Journal article, 2019)Discrimination between low- and high-grade endometrial carcinomas (ECs) is clinically relevant but can be challenging for pathologists, with moderate interobserver agreement. Insulin-like growth factor-II mRNA-binding ... -
Addressing the threat of AMR in Norway: optimising antibiotic prescribing and microbiology testing in hospitals
(Doctoral thesis, 2019-06-14)Increasing antimicrobial resistance rates are recognised as a global public health threat and many efforts are being undertaken to curb this development. One important measure is to optimise the use of antibiotics and ... -
Adenosine Deaminase Activity Is a Sensitive Marker for the Diagnosis of Tuberculous Pleuritis in Patients with Very Low CD4 Counts
(Peer reviewed; Journal article, 2008-07-30)Background: Adenosine Deaminase Activity (ADA) is a commonly used marker for the diagnosis of tuberculous pleural effusion. There has been concern about its usefulness in immunocompromised patients, especially HIV positive ... -
Adherence to the Healthy Nordic Food Index and the incidence of acute myocardial infarction and mortality among patients with stable angina pectoris
(Peer reviewed; Journal article, 2018-08-08)Background: The Healthy Nordic Food Index (HNFI) has been associated with beneficial effects on markers of cardiovascular disease (CVD). Whether such effects are present among patients with established coronary heart disease ... -
Adjusting team involvement: a grounded theory study of challenges in utilizing a surgical safety checklist as experienced by nurses in the operating room
(Peer reviewed; Journal article, 2012-09-07)Background: Even though the use of perioperative checklists have resulted in significant reduction in postoperative mortality and morbidity, as well as improvements of important information communication, the utilization ... -
Adjuvant treatment: the contribution of expression microarrays
(Peer reviewed; Journal article, 2007-12-20) -
Aetiology, antimicrobial therapy and outcome of patients with community acquired severe sepsis: a prospective study in a Norwegian university hospital
(Peer reviewed; Journal article, 2014-03-04)Background: Severe sepsis is recognized as an inflammatory response causing organ dysfunction in patients with infection. Antimicrobial therapy is the mainstay of treatment. There is an ongoing demand for local surveillance ... -
Afferent arteriolopathy and glomerular collapse but not segmental sclerosis induce tubular atrophy in old spontaneously hypertensive rats
(Peer reviewed; Journal article, 2011-06-10)In chronic renal disease, the temporal and spatial relationship between vascular, glomerular and tubular changes is still unclear. Hypertension, an important cause of chronic renal failure, leads to afferent arteriolopathy, ...