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  • Potassium channels in behavioral brain disorders. Molecular mechanisms and therapeutic potential: A narrative review 

    Alam, Kazi Asraful; Svalastoga, Pernille; Martinez, Aurora; Glennon, Jeffrey Colm; Haavik, Jan (Journal article; Peer reviewed, 2023)
    Potassium channels (K+-channels) selectively control the passive flow of potassium ions across biological membranes and thereby also regulate membrane excitability. Genetic variants affecting many of the human K+-channels ...
  • Tryptophan and kynurenine pathway metabolites in neuropsychiatric disorders 

    Aarsland, Tore Ivar Malmei (Doctoral thesis, 2024-05-21)
    Bakgrunn: Kynureninar er ei gruppe metabolittar av den kosthaldsavhengige aminosyra tryptofan (Trp) som er involverte i ei rekkje biologiske mekanismar, mellom anna inflammasjon og reguleringa av nevrotransmitteren glutamat. ...
  • Survival in a consecutive series of 467 glioblastoma patients: Association with prognostic factors and treatment at recurrence at two independent institutions 

    Blakstad, Hanne Kristin; Brekke, Jorunn; Rahman, Mohummad Aminur; Arnesen, Victoria Smith; Miletic, Hrvoje; Brandal, Petter; Lie, Stein Atle; Enger, Martha; Goplen, Dorota (Journal article; Peer reviewed, 2023-02-02)
    Therapy of recurrent glioblastoma (GBM) is challenging due to lack of standard treatment. We investigated physicians’ treatment choice at recurrence and prognostic and predictive factors for survival in GBM patients from ...
  • Characterization of Melanoma Brain Metastasis Cell Lines 

    Bjørnstad, Ole Vidhammer (Master thesis, 2019-06-03)
    Brain metastasis is a major public health problem. Metastatic brain tumors are ten times more common than that of all other primary brain tumors combined. The estimated annual incidence in Europe is around 1.5 million cases ...
  • Identification of a core EMT signature that separates basal-like breast cancers into partial- and post-EMT subtypes 

    Knutsen, Erik; Sajib, Saikat Das; Fiskaa, Tonje; Lorens, James Bradley; Gudjonsson, Thorarinn; Mælandsmo, Gunhild Mari; Johansen, Steinar Daae; Seternes, Ole Morten; Perander, Maria (Journal article; Peer reviewed, 2023)
    Epithelial-mesenchymal transition (EMT) is a cellular plasticity program critical for embryonic development and tissue regeneration, and aberrant EMT is associated with disease including cancer. The high degree of plasticity ...
  • Cardiac Involvement in Systemic and Local Vasculitides: The Value of Noninvasive Multimodality Imaging 

    Mohamed Ali, Abukar; Yakupoglu, H. Yakup; Fuchs, Tobias A.; Larsen, Terje Hjalmar; Aukrust, Pål; Gunnarsson, Ragnar; Saeed, Sahrai (Journal article; Peer reviewed, 2023)
    Despite significant advances in managing systemic vasculitides, cardiovascular morbidity, and mortality are still of primary concern. Advances in noninvasive imaging have broadened our understanding of the clinical ...
  • Quality indicators and early adverse in surgery for atypical meningiomas: A 16-year single centre study and systematic review of the literature 

    Schipmann, Stephanie; Sletvold, Truls P.; Wollertsen, Yvonne; Schwake, Michael; Raknes, Ingrid Cecilie; Miletic, Hrvoje; Mahesparan, Rupavathana (Journal article; Peer reviewed, 2023)
    Introduction Atypical meningiomas represent approximately 20% of all intracranial meningiomas and are characterized by distinct histopathological criteria and an increased risk of postoperative recurrence. Recently, ...
  • Monoamine synthesis in neurometabolic disorders affecting catecholaminergic functioning: biochemical mechanisms and treatment implications 

    Szigetvari, Peter Daniel (Doctoral thesis, 2024-02-14)
    Løpet av de siste 100 år er det oppdaget hundrevis av arvelige metabolske forstyrrelser. Slike tilstander har ofte recessiv Mendelsk arv og kalles også medfødte metabolismefeil. Symptomene debuterer vanligvis like etter ...
  • The effects of phenylalanine and tyrosine levels on dopamine production in rat PC12 cells. Implications for treatment of phenylketonuria, tyrosinemia type 1 and comorbid neurodevelopmental disorders 

    Szigetvari, Peter Daniel; Patil, Sudarshan; Birkeland, Even; Kleppe, Rune; Haavik, Jan (Journal article; Peer reviewed, 2023)
    Phenylketonuria (PKU) is an autosomal recessive metabolic disorder caused by mutations in the phenylalanine hydroxylase (PAH) gene, resulting in phenylalanine accumulation and impaired tyrosine production. In Tyrosinemia ...
  • The quaternary structure of human tyrosine hydroxylase: effects of dystonia‐associated missense variants on oligomeric state and enzyme activity 

    Szigetvari, Peter Daniel; Muruganandam, Gopinath; Kallio, Juha; Hallin, Erik Ingmar; Fossbakk, Agnete; Loris, Remy; Kursula, Inari; Møller, Lisbeth Birk; Knappskog, Per; Kursula, Petri; Haavik, Jan (Journal article; Peer reviewed, 2019)
    Tyrosine hydroxylase (TH) is a multi-domain, homo-oligomeric enzyme that catalyses the rate-limiting step of catecholamine neurotransmitter biosynthesis. Missense variants of human TH are associated with a recessive ...
  • Electroconvulsive therapy-induced volumetric brain changes converge on a common causal circuit in depression 

    Argyelan, Miklos; Deng, Zhi-De; Ousdal, Olga Therese; Oltedal, Leif; Angulo, Brian; Baradits, Mate; Spitzberg, Andrew J.; Kessler, Ute; Sartorius, Alexander; Dols, Annemiek; Narr, Katherine L.; Espinoza, Randall; van Waarde, Jeroen A.; Tendolkar, Indira; van Eijndhoven, Philip; van Wingen, Guido A.; Takamiya, Akihiro; Kishimoto, Taishiro; Jorgensen, Martin B.; Jorgensen, Anders; Paulson, Olaf B.; Yrondi, Antoine; Péran, Patrice; Soriano-Mas, Carles; Cardoner, Narcis; Cano, Marta; van Diermen, Linda; Schrijvers, Didier; Belge, Jean-Baptiste; Emsell, Louise; Bouckaert, Filip; Vandenbulcke, Mathieu; Kiebs, Maximilian; Hurlemann, René; Mulders, Peter Cr.; Redlich, Ronny; Dannlowski, Udo; Erhan, Kavakbasi; Kritzer, Michael D.; Ellard, Kristen K.; Camprodon, Joan A.; Petrides, Georgios; Malhotra, Anil K.; Abbott, Christopher C. (Journal article; Peer reviewed, 2023)
    Neurostimulation is a mainstream treatment option for major depression. Neuromodulation techniques apply repetitive magnetic or electrical stimulation to some neural target but significantly differ in their invasiveness, ...
  • Cuprizone and EAE mouse frontal cortex proteomics revealed proteins altered in multiple sclerosis 

    Oveland, Eystein; Ahmad, Intakhar; Lereim, Ragnhild Reehorst; Kroksveen, Ann Cathrine; Barsnes, Harald; Guldbrandsen, Astrid; Myhr, Kjell-Morten; Bø, Lars; Berven, Frode Steingrimsen; Wergeland, Stig (Journal article; Peer reviewed, 2021)
    Two pathophysiological different experimental models for multiple sclerosis were analyzed in parallel using quantitative proteomics in attempts to discover protein alterations applicable as diagnostic-, prognostic-, or ...
  • Detection of Arc/Arg3.1 oligomers in rat brain: constitutive and synaptic activity-evoked dimer expression in vivo 

    Mergiya, Tadiwos Feyissa; Gundersen, Jens Edvard Trygstad; Kanhema, Tambudzai; Brighter, Grant Mitchell; Ishizuka, Yuta; Bramham, Clive Raymond Evjen (Journal article; Peer reviewed, 2023)
    The immediate early gene product activity-regulated cytoskeleton-associated protein (Arc or Arg3.1) is a major regulator of long-term synaptic plasticity with critical roles in postnatal cortical development and memory ...
  • GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity 

    Watson, Dionysios C.; Bayik, Defne; Storevik, Simon Humberto; Moreino, Shannon Sherwin; Sprowls, Samuel A.; Han, Jianhua; Augustsson, Mina Thue; Lauko, Adam; Sravya, Palavalasa; Røsland, Gro Vatne; Troike, Katie; Tronstad, Karl Johan; Wang, Sabrina; Sarnow, Katharina; Kay, Kristen; Lunavat, Taral; Silver, Daniel J.; Dayal, Sahil; Vareecal Joseph, Justin; Mulkearns-Hubert, Erin; Ystaas, Lars Andreas Rømo; Deshpande, Gauravi; Guyon, Joris; Zhou, Yadi; Magaut, Capucine R.; Seder, Juliana; Neises, Laura; Williford, Sarah E.; Meiser, Johannes; Scott, Andrew J.; Sajjakulnukit, Peter; Mears, Jason A.; Bjerkvig, Rolf; Chakraborty, Abhishek; Daubon, Thomas; Cheng, Feixiong; Lyssiotis, Costas A.; Wahl, Daniel R.; Hjelmeland, Anita B.; Hossain, Md Jubayer al; Miletic, Hrvoje; Lathia, Justin D. (Journal article; Peer reviewed, 2023)
    The transfer of intact mitochondria between heterogeneous cell types has been confirmed in various settings, including cancer. However, the functional implications of mitochondria transfer on tumor biology are poorly ...
  • Inhibition of extracellular vesicle-derived miR-146a-5p decreases progression of melanoma brain metastasis via Notch pathway dysregulation in astrocytes 

    Rigg, Emma Kayleigh; Wang, Jiwei; Xue, Zhiwei; Lunavat, Taral; Liu, Guowei; Hoang, Tuyen; Parajuli, Himalaya; Han, Mingzhi; Bjerkvig, Rolf; Nazarov, Petr V.; Nicot, Nathalie; Kreis, Stephanie; Margue, Christiane; Nomigni, Miléne Tetsi; Utikal, Jochen; Miletic, Hrvoje; Sundstrøm, Terje; Ystaas, Lars Andreas Rømo; Li, Xingang; Thorsen, Frits (Journal article; Peer reviewed, 2023)
    Melanoma has the highest propensity of all cancers to metastasize to the brain with a large percentage of late-stage patients developing metastases in the central nervous system (CNS). It is well known that metastasis ...
  • Feasibility of deep learning-based tumor segmentation for target delineation and response assessment in grade-4 glioma using multi-parametric MRI 

    Hannisdal, Marianne Hjellvik; Goplen, Dorota; Alam, Saruar; Haász, Judit; Oltedal, Leif; Rahman, Mohummad Aminur; Rygh, Cecilie Brekke; Lie, Stein Atle; Lundervold, Arvid; Enger, Martha (Journal article; Peer reviewed, 2023)
    Background Tumor burden assessment is essential for radiation therapy (RT), treatment response evaluation, and clinical decision-making. However, manual tumor delineation remains laborious and challenging due to ...
  • Case report: ADHD and prognosis in tyrosinemia type 1 

    Halleland, Helene; Elgen, Irene Bircow; Bliksrud, Yngve Thomas; Hansen, Eirik Vangsøy; Skavhellen, Rita Rigmor; Furevik, Magne Ivar; Haavik, Jan (Journal article; Peer reviewed, 2023-07-18)
    Neurometabolic disorders such as tyrosinemia type 1 (TYRSN1) may interfere with brain metabolism and show symptoms of attention-deficit hyperactivity disorder (ADHD) in patients treated with the enzyme inhibitor nitisinone ...
  • VEGF-B hypertrophy predisposes to transition from diastolic to systolic heart failure in hypertensive rats 

    Samuelsson, Anne-Maj; Bartolomaeus, Theda Ulrike Patricia; Anandakumar, Harithaa; Thowsen, Irene Matre; Nikpey, Elham; Han, Jianhua; Marko, Lajos; Finne, Kenneth; Tenstad, Olav; Eckstein, Johannes; Berndt, Nikolaus; Kühne, Titus; Kedziora, Sarah; Sultan, Ibrahim; Skogstrand, Trude; Karlsen, Tine Veronica; Nurmi, Harri; Forslund, Sofia K.; Bollano, Entela; Alitalo, Kari; Muller, Dominik N.; Wiig, Helge (Journal article; Peer reviewed, 2023)
    Aims: Cardiac energy metabolism is centrally involved in heart failure (HF), although the direction of the metabolic alterations is complex and likely dependent on the particular stage of HF progression. Vascular endothelial ...
  • PARP14 is a PARP with both ADP-ribosyl transferase and hydrolase activities 

    Đukić, Nina; Strømland, Øyvind; Elsborg, Jonas Damgaard; Munnur, Deeksha; Zhu, Kang; Schuller, Marion; Chatrin, Chatrin; Kar, Pulak; Duma, Lena; Suyari, Osamu; Rack, Johannes Gregor Matthias; Baretić, Domagoj; Crudgington, Dorian Richard Kenneth; Groslambert, Joséphine; Fowler, Gerissa; Wijngaarden, Sven; Prokhorova, Evgeniia; Rehwinkel, Jan; Schüler, Herwig; Filippov, Dmitri V.; Sanyal, Sumana; Ahel, Dragana; Nielsen, Michael L.; Smith, Rebecca; Ahel, Ivan (Journal article; Peer reviewed, 2023)
    PARP14 is a mono–ADP-ribosyl transferase involved in the control of immunity, transcription, and DNA replication stress management. However, little is known about the ADP-ribosylation activity of PARP14, including its ...
  • Protein target highlights in CASP15: Analysis of models by structure providers 

    Alexander, Leila T.; Durairaj, Janani; Kryshtafovych, Andriy; Abriata, Luciano A.; Bayo, Yusupha; Bhabha, Gira; Breyton, Cécile; Caulton, Simon G.; Chen, James; Degroux, Séraphine; Ekiert, Damian C.; Erlandsen, Benedikte S.; Freddolino, Peter L.; Gilzer, Dominic; Greening, Chris; Grimes, Jonathan M.; Grinter, Rhys; Gurusaran, Manickam; Hartmann, Marcus D.; Hitchman, Charlie J.; Keown, Jeremy R.; Kropp, Ashleigh; Kursula, Petri Tapani; Lovering, Andrew L.; Lemaitre, Bruno; Lia, Andrea; Liu, Shiheng; Logotheti, Maria; Lu, Shuze; Markusson, Sigurbjörn; Miller, Mitchell D.; Minasov, George; Niemann, Hartmut H.; Opazo, Felipe; Phillips, George N.; Davies, Owen R.; Rommelaere, Samuel; Rosas-Lemus, Monica; Roversi, Pietro; Satchell, Karla; Smith, Nathan; Wilson, Mark A.; Wu, Kuan-Lin; Xia, Xian; Xiao, Han; Zhang, Wenhua; Zhou, Z. Hong; Fidelis, Krzysztof; Topf, Maya; Moult, John; Schwede, Torsten (Journal article; Peer reviewed, 2023)
    We present an in-depth analysis of selected CASP15 targets, focusing on their biological and functional significance. The authors of the structures identify and discuss key protein features and evaluate how effectively ...

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