Department of Biomedicine
Nye registreringer
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Use of big data and machine learning algorithms to extract possible treatment targets in neurodevelopmental disorders
(Journal article; Peer reviewed, 2023)Neurodevelopmental disorders (NDDs) impact multiple aspects of an individual's functioning, including social interactions, communication, and behaviors. The underlying biological mechanisms of NDDs are not yet fully ... -
The pancreas remembers: epigenetic memory of obesity as subtle, coordinated changes in promoter accessibility
(Master thesis, 2024-06-03)Background: Epigenetic memory involves heritable gene expression changes without DNA sequence alterations, impacting cellular functions long after the initial triggers have ceased. The impact of obesity on pancreatic ... -
Probing cellular interactions in breast cancer and mouse models thereof
(Master thesis, 2024-06-03)The thesis is divided into two different topics: 1. Identifying which receptor, the S100A8 protein is binding to in obesity-induced breast cancer. 2. Implementing a new model for breast cancer in the proper cellular ... -
Molecular pathways of mitochondria transfer in Glioblastoma cells
(Master thesis, 2024-06-03)Glioblastoma (GBM) is a malignant brain tumor and the most aggressive form of brain cancer in adults. The aggressive nature and invasive properties of GBM cells contribute to the poor prognosis and increased rate of ... -
HER2, Tissue Factor, TROP2 and NECTIN4 as targets for antibody-drug conjugate (ADC) therapy in cervical cancer
(Master thesis, 2024-06-03)Early-stage cervical cancers are generally associated with good prognosis. However, for late stage or recurrent disease, survival rates drop significantly, with limited treatment options available. Antibody drug conjugates ... -
eIF4E phosphorylation recruits β-catenin to mRNA cap and promotes Wnt pathway translation in dentate gyrus LTP maintenance
(Journal article; Peer reviewed, 2023)The mRNA cap-binding protein, eukaryotic initiation factor 4E (eIF4E), is crucial for translation and regulated by Ser209 phosphorylation. However, the biochemical and physiological role of eIF4E phosphorylation in ... -
Valtrate, an iridoid compound in Valeriana, elicits anti-glioblastoma activity through inhibition of the PDGFRA/MEK/ERK signaling pathway
(Journal article; Peer reviewed, 2023)Background Valtrate, a natural compound isolated from the root of Valeriana, exhibits antitumor activity in many cancers through different mechanisms. However, its efficacy for the treatment of glioblastoma (GBM), a ... -
Structural properties of the HNF-1A transactivation domain
(Journal article; Peer reviewed, 2023)Hepatocyte nuclear factor 1α (HNF-1A) is a transcription factor with important gene regulatory roles in pancreatic β-cells. HNF1A gene variants are associated with a monogenic form of diabetes (HNF1A-MODY) or an increased ... -
Characterization and Tracking of Melanoma and Lung Brain Metastasis-Derived Extracellular Vesicles in vitro
(Master thesis, 2024-06-03)Brain metastasis (BM) occurs when cancer cells from a primary tumor elsewhere in the body spread to the brain. It poses significant challenges in cancer treatment due to its aggressive nature and limited therapeutic options, ... -
Image Registration for Automated Alignment and Ordering of Non-neoplastic Kidney Biopsy Sections
(Master thesis, 2024-06-03)The kidney, a vital organ responsible for waste excretion and hormone regulation, is frequently afflicted by non-neoplastic diseases affecting components like glomeruli and tubules. Chronic kidney disease (CKD), often ... -
Interplay of the proteotoxic CEL-MODY protein and oncogenic KRAS in pancreatic cancer development
(Master thesis, 2024-06-03)Challenges in diagnosing and treating pancreatic cancer make it the fourth-leading cause of cancer-related deaths. Survival rates remain dismally low, and the molecular mechanisms driving this malignancy are still inadequately ... -
Novel aspects of carboxyl ester lipase (CEL). Investigations on transcriptional regulation and tissue expression
(Master thesis, 2024-06-03)Carboxyl ester lipase (CEL) is a digestive enzyme that breaks down dietary fats in the duodenum, and it is mainly expressed by the pancreas and lactating mammary glands. A pathogenic variant of the CEL gene, named CEL-HYB1, ... -
Role of mechanotransduction in pancreatic endocrine cell fate acquisition in SC-islets
(Master thesis, 2024-06-03) -
Potassium channels in behavioral brain disorders. Molecular mechanisms and therapeutic potential: A narrative review
(Journal article; Peer reviewed, 2023)Potassium channels (K+-channels) selectively control the passive flow of potassium ions across biological membranes and thereby also regulate membrane excitability. Genetic variants affecting many of the human K+-channels ... -
Tryptophan and kynurenine pathway metabolites in neuropsychiatric disorders
(Doctoral thesis, 2024-05-21)Bakgrunn: Kynureninar er ei gruppe metabolittar av den kosthaldsavhengige aminosyra tryptofan (Trp) som er involverte i ei rekkje biologiske mekanismar, mellom anna inflammasjon og reguleringa av nevrotransmitteren glutamat. ... -
Survival in a consecutive series of 467 glioblastoma patients: Association with prognostic factors and treatment at recurrence at two independent institutions
(Journal article; Peer reviewed, 2023-02-02)Therapy of recurrent glioblastoma (GBM) is challenging due to lack of standard treatment. We investigated physicians’ treatment choice at recurrence and prognostic and predictive factors for survival in GBM patients from ... -
Characterization of Melanoma Brain Metastasis Cell Lines
(Master thesis, 2019-06-03)Brain metastasis is a major public health problem. Metastatic brain tumors are ten times more common than that of all other primary brain tumors combined. The estimated annual incidence in Europe is around 1.5 million cases ... -
Identification of a core EMT signature that separates basal-like breast cancers into partial- and post-EMT subtypes
(Journal article; Peer reviewed, 2023)Epithelial-mesenchymal transition (EMT) is a cellular plasticity program critical for embryonic development and tissue regeneration, and aberrant EMT is associated with disease including cancer. The high degree of plasticity ...