• Fluid transport from the dental pulp revisited. 

  Berggreen, Ellen; Wiig, Helge; Virtej, Anca (Journal article; Peer reviewed, 2020-10)

  In the dental pulp surrounded by rigid dentinal walls, an increase in fluid volume will be followed by a rapid increase in interstitial fluid pressure. To maintain pressure homeostasis, a fluid drainage system is required. ...

• Revealing and Harnessing Tumour-Associated Microglia/Macrophage Heterogeneity in Glioblastoma 

  Pires-Afonso, Yolanda; Niclou, Simone Pierrette; Michelucci, Alessandro (Journal article; Peer reviewed, 2020)

  Cancer heterogeneity and progression are subject to complex interactions between neoplastic cells and their microenvironment, including the immune system. Although glioblastomas (GBMs) are classified as ‘cold tumours’ with ...

• A multi-layer perceptron network for perfusion parameter estimation in DCE-MRI studies of the healthy kidney 

  Klepaczko, Artur; Strzelecki, Michał; Kociołek, Marcin; Eikefjord, Eli Bjøvad; Lundervold, Arvid (Journal article; Peer reviewed, 2020)

  Background: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is an imaging technique which helps in visualizing and quantifying perfusion—one of the most important indicators of an organ’s state. This paper ...

• Mechanism of actin N-terminal acetylation 

  Rebowski, Grzegorz; Boczkowska, Malgorzata; Drazic, Adrian; Ree, Rasmus Moen; Goris, Marianne; Arnesen, Thomas; Dominguez, Roberto (Journal article; Peer reviewed, 2020)

  About 80% of human proteins are amino-terminally acetylated (Nt-acetylated) by one of seven Nt-acetyltransferases (NATs). Actin, the most abundant protein in the cytoplasm, has its own dedicated NAT, NAA80, which acts ...

• Flexible Players within the Sheaths: The Intrinsically Disordered Proteins of Myelin in Health and Disease 

  Raasakka, Arne; Kursula, Petri (Journal article; Peer reviewed, 2020)

  Myelin ensheathes selected axonal segments within the nervous system, resulting primarily in nerve impulse acceleration, as well as mechanical and trophic support for neurons. In the central and peripheral nervous systems, ...

• Melatonin enhances proliferation and modulates differentiation of neural stem cells via autophagy in hyperglycemia 

  Li, Haoyuan; Zhang, Yanming; Liu, Shangming; Li, Fengpeng; Wang, Benlin; Wang, Jianjie; Cao, Lanfang; Xia, Tongliang; Yao, Qingyu; Chen, Haijun; Zhang, Yulin; Zhu, Xiaodong; Li, Yang; Li, Gang; Wang, Jian; Li, Xingang; Ni, Shilei (Journal article; Peer reviewed, 2019-01)

  Dysfunction of neural stem cells (NSCs) has been linked to fetal neuropathy, one of the most devastating complications of gestational diabetes. Several studies have demonstrated that melatonin (Mel) exerted neuroprotective ...

• Molecular basis for N-terminal acetylation by human NatE and its modulation by HYPK 

  Deng, Sunbin; Mc Tiernan, Nina; Wei, Xuepeng; Arnesen, Thomas; Marmorstein, Ronen (Journal article; Peer reviewed, 2020-02)

  The human N-terminal acetyltransferase E (NatE) contains NAA10 and NAA50 catalytic, and NAA15 auxiliary subunits and associates with HYPK, a protein with intrinsic NAA10 inhibitory activity. NatE co-translationally acetylates ...

• How Does Protein Zero Assemble Compact Myelin? 

  Raasakka, Arne; Kursula, Petri (Journal article; Peer reviewed, 2020-08)

  Myelin protein zero (P0), a type I transmembrane protein, is the most abundant protein in peripheral nervous system (PNS) myelin—the lipid-rich, periodic structure of membrane pairs that concentrically encloses long axonal ...

• Studies on the Molecular Mechanisms of the Bystander Effect in HSV-TK mediated Suicide Gene Therapy for Glioblastoma Treatment 

  Jeyendran, Sayintha (Master thesis, 2020-08-07)

• A study on metabolic rewiring in cancer cell plasticity 

  Dyrstad, Sissel Elisabeth (Doctoral thesis, 2020-08-21)

  Adaptation of cellular energetics is an important feature of tumorigenesis as a vast supply of nutrients is needed to accommodate increased growth. Essential energy pathways includes glucose, fatty acid and amino acid ...

• Actin Post-translational Modifications: The Cinderella of Cytoskeletal Control 

  Varland, Sylvia; Vandekerckhove, Joel; Drazic, Adrian (Peer reviewed; Journal article, 2019)

  Actin is one of the most abundant proteins in eukaryotic cells and the main component of the microfilament system. It plays essential roles in numerous cellular activities including muscle contraction, maintenance of cell ...

• Integrin α11 cytoplasmic tail is required for FAK activation to initiate 3D cell invasion and ERK-mediated cell proliferation 

  Murugan Erusappan, Pugazendhi; Alam, Jahedul; Lu, Ning; Zeltz, Cedric; Gullberg, Donald (Peer reviewed; Journal article, 2019)

  Integrin α11β1 is a collagen-binding integrin, which is receiving increasing attention in the context of wound healing and fibrosis. Although α11β1 integrin displays similar collagen specificity to α2β1 integrin, both ...

• Interfering with long non-coding RNA MIR22HG processing inhibits glioblastoma progression through suppression of Wnt/β-catenin signalling 

  Han, Mingzhi; Wang, Shuai; Fritah, Sabrina; Wang, Xu; Zhou, Wenjing; Yang, Ning; Ni, Shilei; Huang, Bin; Chen, Anjing; Li, Gang; Miletic, Hrvoje; Thorsen, Frits; Bjerkvig, Rolf; Li, Xingang; Wang, Jian (Peer reviewed; Journal article, 2020)

  Long non-coding RNAs play critical roles in tumour progression. Through analysis of publicly available genomic datasets, we found that MIR22HG, the host gene of microRNAs miR-22-3p and miR-22-5p, is ranked among the most ...

• Ionic strength and calcium regulate membrane interactions of myelin basic protein and the cytoplasmic domain of myelin protein zero 

  Raasakka, Arne; Jones, Nykola C; Hoffmann, Søren V; Kursula, Petri (Peer reviewed; Journal article, 2019)

  The formation of a mature myelin sheath in the vertebrate nervous system requires specific protein-membrane interactions. Several myelin-specific proteins are involved in stacking lipid membranes into multilayered structures ...

• Mitochondrial DNA depletion in sporadic inclusion body myositis 

  Bhatt, Padmanabh S.; Tzoulis, Charalampos; Balafkan, Novin; Miletic, Hrvoje; Tran, Gia Tuong Thi; Sanaker, Petter Schandl; Bindoff, Laurence (Peer reviewed; Journal article, 2019)

  Sporadic inclusion body myositis (sIBM) is a late onset disorder of unkown aetiology. Mitochondrial changes such as cytochrome oxidase deficient fibres are a well recognised feature and mitochondrial DNA (mtDNA) deletions ...

• Impact of Docetaxel on blood-brain barrier function and formation of breast cancer brain metastases 

  Bernatz, Simon; Ilina, Elena I.; Devraj, Kavi; Harter, Patrick N.; Mueller, Klaus; Kleber, Sascha; Braun, Yannick; Penski, Cornelia; Renner, Christoph; Halder, Rashi; Jennewein, Lukas; Solbach, Christine; Thorsen, Frits; Pestalozzi, Bernhard C.; Mischo, Axel; Mittelbronn, Michael (Peer reviewed; Journal article, 2019-10-29)

  Background: Breast cancer (BC) is the most frequent malignant tumor in females and the 2nd most common cause of brain metastasis (BM), that are associated with a fatal prognosis. The increasing incidence from 10% up to 40% ...

• Immune checkpoint molecule herpes virus entry mediator is overexpressed and associated with poor prognosis in human glioblastoma 

  Han, Mingzhi; Wang, Shuai; Zhao, Wen-Bo; Ni, Shi-Lei; Yang, Ning; Kong, Yang; Huang, Bin; Chen, An-Jing; Li, Xin-Gang; Wang, Jian; Wang, Dong-Hai (Peer reviewed; Journal article, 2019)

  Background: Dysregulation of immune checkpoint molecules leads to immune evasion in human tumours but has become a viable target for tumour therapy. Here, we examined expression of Herpes virus entry mediator (HVEM), an ...

• Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis 

  Gucek, Alenka; Gandasi, Nikhil R.; Omar-Hmeadi, Muhmmad; Bakke, Marit; Doskeland, Stein Ove; Tengholm, Anders; Barg, Sebastian (Peer reviewed; Journal article, 2019-05-20)

  Regulated exocytosis establishes a narrow fusion pore as initial aqueous connection to the extracellular space, through which small transmitter molecules such as ATP can exit. Co-release of polypeptides and hormones like ...

• Identification of a potential allosteric site of Golgi α-mannosidase II using computer-aided drug design 

  Irsheid, Lina; Wehler, Thomas; Borek, Christoph; Kiefer, Werner; Brenk, Ruth; Ortiz-Soto, Maria Elena; Seibel, Jurgen; Schirmeister, Tanja (Peer reviewed; Journal article, 2019-05-08)

  Golgi α-mannosidase II (GMII) is a glycoside hydrolase playing a crucial role in the N-glycosylation pathway. In various tumour cell lines, the distribution of N-linked sugars on the cell surface is modified and correlates ...

• PMEPA1 isoform a drives progression of glioblastoma by promoting protein degradation of the Hippo pathway kinase LATS1 

  Ji, Jianxiong; Ding, Kaikai; Luo, Tao; Xu, Ran; Zhang, Xin; Huang, Bin; Chen, An-Jing; Zhang, Di; Miletic, Hrvoje; Bjerkvig, Rolf; Thorsen, Frits; Wang, Jian; Li, Xingang (Peer reviewed; Journal article, 2019)

  The Hippo signaling pathway controls organ development and is also known, in cancer, to have a tumor suppressing role. Within the Hippo pathway, we here demonstrate, in human gliomas, a functional interaction of a transmembrane ...

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