• Digital reconstruction and quantitative morphometric analysis of bipolar cells in live rat retinal slices 

  Fournel, Rémi; Veruki, Margaret Lin; Hartveit, Espen (Journal article; Peer reviewed, 2022)

  Bipolar cells convey signals from photoreceptors in the outer retina to amacrine and ganglion cells in the inner retina. In mammals, there are typically 10–15 types of cone bipolar cells and one type of rod bipolar cell. ...

• Multiple sclerosis and myelin basic protein: insights into protein disorder and disease 

  Martinsen, Vebjørn; Kursula, Petri (Journal article; Peer reviewed, 2022)

  Myelin basic protein (MBP) is an abundant protein in central nervous system (CNS) myelin. MBP has long been studied as a factor in the pathogenesis of the autoimmune neurodegenerative disease multiple sclerosis (MS). MS ...

• Gene-Environment Interactions in Attention-Deficit/Hyperactivity Disorder Symptom Dimensions: The Role of Unhealthy Food Habits 

  Li, Lin; Taylor, Mark J; Bälter, Katarina; xie, tian; Solberg, Berit Skretting; Haavik, Jan; Arias-Vásquez, Alejandro; Hartman, Catharina A; Larsson, Henrik (Journal article; Peer reviewed, 2021)

  Background: Dietary habits were investigated as environmental risk factors for Attention-Deficit/Hyperactivity Disorder (ADHD). However, no previous studies explored the effects of dietary factors on modifying the role of ...

• Crystal and solution structures reveal oligomerization of individual capsid homology domains of Drosophila Arc 

  Hallin, Erik Ingmar; Markusson, Sigurbjörn; Bottger, Lev; Torda, Andrew E.; Bramham, Clive Raymond Evjen; Kursula, Petri (Journal article; Peer reviewed, 2021)

  Synaptic plasticity is vital for brain function and memory formation. One of the key proteins in long-term synaptic plasticity and memory is the activity-regulated cytoskeleton-associated protein (Arc). Mammalian Arc forms ...

• Protocol for derivation of organoids and patient-derived orthotopic xenografts from glioma patient tumors 

  Oudin, Anaïs; Baus, Virginie; Barthelemy, Vanessa; Fabian, Carina; Klein, Eliane; Dieterle, Monika; Wantz, May; Hau, Ann-Christin; Dording, Claire; Bernard, Amandine; Michelucci, Alessandro; Yabo, Yahaya A.; Kanli, Georgia; Keunen, Olivier; Bjerkvig, Rolf; Niclou, Simone Pierrette; Golebiewska, Anna (Journal article; Peer reviewed, 2021)

  Tumor organoids and patient-derived orthotopic xenografts (PDOXs) are some of the most valuable pre-clinical tools in cancer research. In this protocol, we describe efficient derivation of organoids and PDOX models from ...

• Pharmacokinetics and pharmacodynamics of t-cell bispecifics in the tumour interstitial fluid 

  Eigenmann, Miro Julian; Karlsen, Tine Veronica; Wagner, Marek; Tenstad, Olav; Weinzierl, Tina; Fauti, Tanja; Grimm, Hans Peter; Skogstrand, Trude; Klein, Christian; Sam, Johannes; Umana, Pablo; Bacac, Marina; Wiig, Helge; Walz, Antje-Christine (Journal article; Peer reviewed, 2021)

  The goal of this study is to investigate the pharmacokinetics in plasma and tumour interstitial fluid of two T-cell bispecifics (TCBs) with different binding affinities to the tumour target and to assess the subsequent ...

• Kidney Segmentation in Renal Magnetic Resonance Imaging - Current Status and Prospects 

  Zollner, Frank G.; Kocinski, Marek Michal; Hansen, Laura; Golla, Alena-Kathrin; Trbalic, Amira Serifovic; Lundervold, Arvid; Materka, Andrzej; Rogelj, Peter (Journal article; Peer reviewed, 2021)

  Magnetic resonance imaging has achieved an increasingly important role in the clinical work-up of renal diseases such chronic kidney disease (CKD). A large panel of parameters have been proposed to diagnose CKD among them ...

• Equilibrative Nucleoside Transporters Mediate the Import of Nicotinamide Riboside and Nicotinic Acid Riboside into Human Cells 

  Kropotov, Andrey; Kulikova, Veronika; Nerinovski, Kirill; Yakimov, Alexander; Svetlova, Maria; Solovjeva, Ljudmila; Sudnitsyna, Julia; Migaud, Marie E.; Khodorkovskiy, Mikhail; Ziegler, Mathias; Nikiforov, Andrey (Journal article; Peer reviewed, 2021)

  Nicotinamide riboside (NR), a new form of vitamin B3, is an effective precursor of nicotinamide adenine dinucleotide (NAD+) in human and animal cells. The introduction of NR into the body effectively increases the level ...

• Structural properties and peptide ligand binding of the capsid homology domains of human Arc 

  Hallin, Erik Ingmar; Bramham, Clive Raymond Evjen; Kursula, Petri (Journal article; Peer reviewed, 2021)

  The activity-regulated cytoskeleton-associated protein (Arc) is important for synaptic plasticity and the normal function of the brain. Arc interacts with neuronal postsynaptic proteins, but the mechanistic details of its ...

• Healthy kidney segmentation in the dce-mr images using a convolutional neural network and temporal signal characteristics 

  Klepaczko, Artur; Eikefjord, Eli Nina; Lundervold, Arvid (Journal article; Peer reviewed, 2021)

  Quantification of renal perfusion based on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) requires determination of signal intensity time courses in the region of renal parenchyma. Thus, selection of voxels ...

• Innate Lymphoid Cells in Skin Homeostasis and Malignancy 

  Wagner, Marek; Koyasu, Shigeo (Journal article; Peer reviewed, 2021)

  Innate lymphoid cells (ILCs) are mostly tissue resident lymphocytes that are preferentially enriched in barrier tissues such as the skin. Although they lack the expression of somatically rearranged antigen receptors present ...

• The World Federation of ADHD International Consensus Statement: 208 Evidence-based conclusions about the disorder 

  Faraone, Stephen; Banaschewski, Tobias; Coghill, David; Zheng, Yi; Biederman, Joseph; Bellgrove, Mark A.; Newcorn, Jeffrey H.; Gignac, Martin; Al Saud, Nouf M.; Manor, Iris; Rohde, Luis Augusto; Yang, Li; Cortese, Samuele; Almagor, Doron; Stein, Mark A.; Albatti, Turki H.; Aljoudi, Haya F.; Alqahtani, Mohammed M.J.; Asherson, Philip; Atwoli, Lukoye; Bölte, Sven; Buitelaar, Jan K.; Crunelle, Cleo L.; Daley, David; Dalsgaard, Søren; Döpfner, Manfred; Espinet, Stacey; Fitzgerald, Michael; Franke, Barbara; Gerlach, Manfred; Haavik, Jan; Hartman, Catharina A.; Hartung, Cynthia M.; Hinshaw, Stephen P.; Hoekstra, Pieter J.; Hollis, Chris; Kollins, Scott H.; Sandra Kooij, Kooij; Kuntsi, Jonna; Larsson, Henrik; Li, Tingyu; Liu, Jing; Merzon, Eugene; Mattingly, Gregory; Mattos, Paulo; McCarthy, Suzanne; Mikami, Amori Yee; Molina, Brooke S.G.; Nigg, Joel T.; Purper-Ouakil, Diane; Omigbodun, Olayinka O.; Polanczyk, Guilherme V.; Pollak, Yehuda; Poulton, Alison S.; Rajkumar, Ravi Philip; Reding, Andrew; Reif, Andreas; Rubia, Katya; Rucklidge, Julia; Romanos, Marcel; Ramos-Quiroga, J. Antoni; Schellekens, Arnt; Scheres, Anouk; Schoeman, Renata; Schweitzer, Julie B.; Shah, Henal; Solanto, Mary V.; Sonuga-Barke, Edmund; Soutullo, César; Steinhausen, Hans-Christoph; Swanson, James M.; Thapar, Anita; Tripp, G; van de Glind, Geurt; Brink, Wim van den; Van der Oord, Saskia; Venter, Andre; Vitiello, Benedetto; Walitza, Susanne; Wang, Yufeng (Journal article; Peer reviewed, 2021)

  Background Misconceptions about ADHD stigmatize affected people, reduce credibility of providers, and prevent/delay treatment. To challenge misconceptions, we curated findings with strong evidence base. Methods We ...

• Antidepressant drugs act by directly binding to TRKB neurotrophin receptors 

  Casarotto, Plinio C.; Girych, Mykhailo; Fred, Senem M.; Kovaleva, Vera; Moliner, Rafael; Enkavi, Giray; Biojone, Caroline; Cannarozzo, Cecilia; Sahu, Madhusmita Pryiadrashini; Kaurinkoski, Katja; Brunello, Cecilia A.; Steinzeig, Anna; Winkel, Frederike; Patil, Sudarshan; Vestring, Stefan; Serchov, Tsvetan; Diniz, Cassiano R.A.F.; Laukkanen, Liina; Cardon, Iseline; Antila, Hanna; Rog, Tomasz; Piepponen, Timo Petteri; Bramham, Clive Raymond Evjen; Normann, Claus; Lauri, Sari E.; Saarma, Mart; Vattulainen, Ilpo; Castrén, Eero (Journal article; Peer reviewed, 2021)

  It is unclear how binding of antidepressant drugs to their targets gives rise to the clinical antidepressant effect. We discovered that the transmembrane domain of tyrosine kinase receptor 2 (TRKB), the brain-derived ...

• DrugPred_RNA—A Tool for Structure-Based Druggability Predictions for RNA Binding Sites 

  Rekand, Illimar Hugo; Brenk, Ruth (Journal article; Peer reviewed, 2021)

  RNA is an emerging target for drug discovery. However, like for proteins, not all RNA binding sites are equally suited to be addressed with conventional drug-like ligands. To this end, we have developed the structure-based ...

• Herpes Simplex Virus Type 1 Neuronal Infection Triggers the Disassembly of Key Structural Components of Dendritic Spines 

  Acuña-Hinrichsen, Francisca; Covarrubias-Pinto, Adriana; Ishizuka, Yuta; Stolzenbach, María Francisca; Martin, Carolina; Salazar, Paula; Castro, Maite A.; Bramham, Clive Raymond Evjen; Otth, Carola (Journal article; Peer reviewed, 2021)

  Herpes simplex virus type 1 (HSV-1) is a widespread neurotropic virus. Primary infection of HSV-1 in facial epithelium leads to retrograde axonal transport to the central nervous system (CNS) where it establishes latency. ...

• Structure of transmembrane prolyl 4-hydroxylase reveals unique organization of EF and dioxygenase domains 

  Myllykoski, Matti; Sutinen, Aleksi; Koski, M. Kristian; Kallio, Juha Pekka; Raasakka, Arne; Myllyharju, Johanna; Wierenga, Rik K.; Koivunen, Peppi (Journal article; Peer reviewed, 2021)

  Prolyl 4-hydroxylases (P4Hs) catalyze post-translational hydroxylation of peptidyl proline residues. In addition to collagen P4Hs and hypoxia-inducible factor P4Hs, a third P4H—the poorly characterized endoplasmic ...

• Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets 

  Postema, Merel C.; Hoogman, Martine; Ambrosino, Sara; Asherson, Philip; Banaschewski, Tobias; Bandeira, Cibele E.; Baranov, Alexandr; Bau, Claiton H.D.; Baumeister, Sarah; Baur-Streubel, Ramona; Bellgrove, Mark A.; Biederman, Joseph; Bralten, Janita; Brandeis, Daniel; Brem, Silvia; Buitelaar, Jan K.; Busatto, Geraldo F.; Castellanos, Francisco X.; Cercignani, Mara; Chaim-Avancini, Tiffany M.; Chantiluke, Kaylita C.; Christakou, Anastasia; Coghill, David; Conzelmann, Annette; Cubillo, Ana; Cupertino, Renata B.; de Zeeuw, Patrick; Doyle, Alysa E.; Durston, Sarah; Earl, Eric A.; Epstein, Jeffery N.; Ethofer, Thomas; Fair, Damien A.; Fallgatter, Andreas J.; Faraone, Stephen V.; Frodl, Thomas; Gabel, Matt C.; Gogberashvili, Tinatin; Grevet, Eugenio H.; Haavik, Jan; Harrison, Neil A.; Hartman, Catharina A.; Heslenfeld, Dirk J.; Hoekstra, Pieter J.; Hohmann, Sarah; Høvik, Marie Farstad; Jernigan, Terry L.; Kardatzki, Bernd; Karkashadze, George A.; Kelly, Clare; Kohls, Gregor; Konrad, Kerstin; Kuntsi, Jonna; Lazaro, Luisa; Lera-Miguel, Sara; Lesch, Klaus-Peter; Louza, Mario R.; Lundervold, Astri J.; Malpas, Charles B.; Mattos, Paulo; McCarthy, Hazel; Namazova-Baranova, Leyla; Nicolau, Rosa; Nigg, Joel T.; Novotny, Stephanie E.; Oberwelland Weiss, Eileen; O'Gorman Tuura, Ruth L.; Oosterlaan, Jaap; Oranje, Bob; Paloyelis, Yannis; Pauli, Paul; Picon, Felipe A.; Plessen, Kerstin J.; Ramos-Quiroga, J. Antoni; Reif, Andreas; Reneman, Liesbeth; Rosa, Pedro G.P.; Rubia, Katya; Schrantee, Anouk; Schweren, Lizanne J.S.; Seitz, Jochen; Shaw, Philip; Silk, Tim J.; Skokauskas, Norbert; Soliva, Joan Carles; Stevens, Michael C.; Sudre, Gustavo; Tamm, Leanne; Tovar-Moll, Fernanda; van Erp, Theo G.M.; Vance, Alasdair; Vilarroya, Oscar; Vives-Gilabert, Yolanda; von Polier, Georg G.; Walitza, Susanne; Yoncheva, Yuliya N.; Zanetti, Marcus V; Ziegler, Georg C.; Glahn, David C.; Jahanshad, Neda; Medland, Sarah E.; Thompson, Paul M.; Fisher, Simon E.; Franke, Barbara; Francks, Clyde (Journal article; Peer reviewed, 2021)

  Objective Some studies have suggested alterations of structural brain asymmetry in attention-deficit/hyperactivity disorder (ADHD), but findings have been contradictory and based on small samples. Here, we performed the ...

• Investigating Shared Genetic Basis Across Tourette Syndrome and Comorbid Neurodevelopmental Disorders Along the Impulsivity-Compulsivity Spectrum 

  Yang, Zhiyu; Wu, Hanrui; Lee, Phil H.; Tsetsos, Fotis; Davis, Lea K.; Yu, Dongmei; Lee, Sang Hong; Dalsgaard, Søren; Haavik, Jan; Barta, Csaba; Zayats, Tetyana; Eapen, Valsamma; Wray, Naomi R.; Devlin, Bernie; Daly, Mark; Neale, Benjamin; Børglum, Anders D.; Crowley, James J.; Scharf, Jeremiah; Mathews, Carol A.; Faraone, Stephen V.; Franke, Barbara; Mattheisen, Manuel; Smoller, Jordan W.; Paschou, Peristera (Journal article; Peer reviewed, 2021)

  Background Tourette syndrome (TS) is often found comorbid with other neurodevelopmental disorders across the impulsivity-compulsivity spectrum, with attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder ...

• Structure of the Complete Dimeric Human GDAP1 Core Domain Provides Insights into Ligand Binding and Clustering of Disease Mutations 

  Nguyen, Giang Thi Tuyet; Sutinen, Aleksi; Raasakka, Arne; Muruganandam, Gopinath; Loris, Remy; Kursula, Petri (Journal article; Peer reviewed, 2021)

  Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neurological disorders. Despite the common involvement of ganglioside-induced differentiation-associated protein 1 (GDAP1) in CMT, the protein structure ...

• An Experimental Toolbox for Structure-Based Hit Discovery for P. aeruginosa FabF, a Promising Target for Antibiotics 

  Espeland, Ludvik Olai; Georgiou, Charis; Klein, Raphael; Bhukya, Hemalatha; Haug, Bengt Erik; Underhaug, Jarl; Mainkar, Prathama S.; Brenk, Ruth (Journal article; Peer reviewed, 2021)

  FabF (3-oxoacyl-[acyl-carrier-protein] synthase 2), which catalyses the rate limiting condensation reaction in the fatty acid synthesis II pathway, is an attractive target for new antibiotics. Here, we focus on FabF from ...

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