Department of Biomedicine
Nye registreringer
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Dietary selenomethionine reduce mercury tissue levels and modulate methylmercury induced proteomic and transcriptomic alterations in hippocampi of adolescent BALB/c mice
(Journal article; Peer reviewed, 2022-10-13)Methylmercury (MeHg) is a well-known environmental contaminant, particularly harmful to the developing brain. The main human dietary exposure to MeHg occurs through seafood consumption. However, seafood also contains several ... -
Arsenic exposure and developmental neurotoxicity: An evaluation of biomarkers of effect.
(Master thesis, 2022-08-01) -
CCT196969 effectively inhibits growth and survival of melanoma brain metastasis cells
(Journal article; Peer reviewed, 2022)Melanomas frequently metastasize to the brain. Despite recent progress in the treatment of melanoma brain metastasis, therapy resistance and relapse of disease remain unsolved challenges. CCT196969 is a SRC family kinase ... -
Quantitative proteomics reveals protein dysregulation during T cell activation in multiple sclerosis patients compared to healthy controls
(Journal article; Peer reviewed, 2022-07-05)Background: Multiple sclerosis (MS) is an autoimmune, neurodegenerative disorder with a strong genetic component that acts in a complex interaction with environmental factors for disease development. CD4+ T cells are pivotal ... -
Inflammatory targeted assessment and laser treatment of knee osteoarthritis : Rater reliability of pain pressure threshold algometry and effectiveness of Low-Level Laser Therapy
(Doctoral thesis, 2022-11-03)Bakgrunn: Ved kneartrose er et høyere nivå av inflammasjon assosiert med mer intens smerte og raskere sykdomsprogresjon. Å redusere kneinflammasjon anbefales derfor som behandlingsmål. Inflammatorisk mediert hyperalgesi ... -
Digital reconstruction, quantitative morphometric analysis, and membrane properties of bipolar cells in the rat retina.
(Doctoral thesis, 2021-09-29)A basic principle of neuroscience is that structure reflects function. This has led to numerous attempts to characterize the complete morphology of types of neurons throughout the central nervous system. The ability to ... -
Evidence for the role of Rab11-positive recycling endosomes as intermediates in coronavirus egress from epithelial cells
(Journal article; Peer reviewed, 2022)After their assembly by budding into the lumen of the intermediate compartment (IC) at the endoplasmic reticulum (ER)–Golgi interface, coronaviruses (CoVs) are released from their host cells following a pathway that remains ... -
Quantitative proteome profiling reveals molecular hallmarks of egg quality in Atlantic halibut: impairments of transcription and protein folding impede protein and energy homeostasis during early development
(Journal article; Peer reviewed, 2022)Background Tandem mass tag spectrometry (TMT labeling-LC-MS/MS) was utilized to examine the global proteomes of Atlantic halibut eggs at the 1-cell-stage post fertilization. Comparisons were made between eggs judged to ... -
Functionalization of Nanoparticles with Tyrosine Hydroxylase : Biotechnological and Therapeutic Implications
(Doctoral thesis, 2022-09-30)Tyrosine hydroxylase (TH) er et viktig enzym for nervesystemet, fordi det katalyserer det første steget i syntesen av dopamin, noradrenalin og adrenalin. Nivået på TH og dopamin synker hos Parkinsons pasienter pga. den ... -
Comparing Efficiency of Lysis Buffer Solutions and Sample Preparation Methods for Liquid Chromatography–Mass Spectrometry Analysis of Human Cells and Plasma
(Journal article; Peer reviewed, 2022)The use of a proper sample processing methodology for maximum proteome coverage and high-quality quantitative data is an important choice to make before initiating a liquid chromatography–mass spectrometry (LC–MS)-based ... -
Structure-based Druggability Predictions of RNA Binding Sites and Design of RNA Ligands
(Doctoral thesis, 2022-09-15)Den post-antibotiske æraen truer og for å møte denne krisen trengs det tilgang til nye klasser av antibiotika. Ribvoswitcher er cis-genregulerende foldete strukturer av ikke-kodende RNA, som handler gjennom konformasjonsendringer ... -
Understanding proteostasis dysregulation in phenylketonuria – a paradigm disease for inborn error of metabolism
(Doctoral thesis, 2022-09-06)Fenylketonuria (PKU) er en medfødt stoffskiftesykdom forårsaket av mutasjoner i genet for fenylalanin hydroksylase (PAH), og fører til ustabile og ofte feilfoldete enzymer med nedsatt evne til å metabolisere aminosyren ... -
Early Evolutionary Selection of NAD Biosynthesis Pathway in Bacteria
(Journal article; Peer reviewed, 2022)Bacteria use two alternative pathways to synthesize nicotinamide adenine dinucleotide (NAD) from nicotinamide (Nam). A short, two-step route proceeds through nicotinamide mononucleotide (NMN) formation, whereas the other ... -
Anti-PD-L1/TGF-βR fusion protein (SHR-1701) overcomes disrupted lymphocyte recovery-induced resistance to PD-1/PD-L1 inhibitors in lung cancer
(Journal article, 2022)Background Second-generation programmed cell death-protein 1/programmed death-ligand 1 (PD-1/PD-L1) inhibitors, such as bintrafusp alfa (M7824), SHR-1701, and YM101, have been developed to simultaneously block PD-1/PD-L1 ... -
Biochemical and biophysical characterisation of HMBS variants associated with acute intermittent porphyria
(Master thesis, 2022-06-01) -
AXL targeting restores PD-1 blockade sensitivity of STK11/LKB1 mutant NSCLC through expansion of TCF1+ CD8 T cells
(Journal article; Peer reviewed, 2022)Mutations in STK11/LKB1 in non-small cell lung cancer (NSCLC) are associated with poor patient responses to immune checkpoint blockade (ICB), and introduction of a Stk11/Lkb1 (L) mutation into murine lung adenocarcinomas ... -
Structural and biophysical characterization of transcription factor HNF-1A as a tool to study MODY3 diabetes variants
(Journal article; Peer reviewed, 2022)Hepatocyte nuclear factor 1A (HNF-1A) is a transcription factor expressed in several embryonic and adult tissues, modulating the expression of numerous target genes. Pathogenic variants in the HNF1A gene are known to cause ... -
Mechanical stress shapes the cancer cell response to neddylation inhibition
(Journal article; Peer reviewed, 2022)Background The inhibition of neddylation by the preclinical drug MLN4924 represents a new strategy to combat cancer. However, despite being effective against hematologic malignancies, its success in solid tumors, where ... -
Development and Validation of Arc Nanobodies: New Tools for Probing Arc Dynamics and Function
(Journal article; Peer reviewed, 2022)Activity-regulated cytoskeleton-associated (Arc) protein plays key roles in long-term synaptic plasticity, memory, and cognitive flexibility. However, an integral understanding of Arc mechanisms is lacking. Arc is proposed ... -
Metabolic flux analysis of 3D spheroids reveals significant differences in glucose metabolism from matched 2D cultures of colorectal cancer and pancreatic ductal adenocarcinoma cell lines
(Journal article; Peer reviewed, 2022)Background Most in vitro cancer cell experiments have been performed using 2D models. However, 3D spheroid cultures are increasingly favored for being more representative of in vivo tumor conditions. To overcome the ...
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