Department of Biomedicine
Recent Submissions
-
The dopamine hypothesis for ADHD: An evaluation of evidence accumulated from human studies and animal models
(Journal article; Peer reviewed, 2024)Multiple lines of evidence indicate that altered dopamine signaling may be involved in neuropsychiatric disorders and common behavioral traits. Here we critically review evidence collected during the past 40-plus years ... -
Dietary protein affects tissue accumulation of mercury and induces hepatic Phase I and Phase II enzyme expression after co-exposure with methylmercury in mice
(Journal article; Peer reviewed, 2024)Methylmercury (MeHg) is a ubiquitous environmental contaminant, well known for its neurotoxic effects. MeHg can interact with several nutrients in the diet and affect nutrient metabolism, however the interaction between ... -
Human serum proteomics reveals a molecular signature after one night of sleep deprivation
(Journal article; Peer reviewed, 2024)Study Objectives Sleep deprivation is highly prevalent and caused by conditions such as night shift work or illnesses like obstructive sleep apnea. Compromised sleep affects cardiovascular-, immune-, and neuronal systems. ... -
Analysis of factors associated with use of real-world data in single technology appraisals of cancer drugs by the National Institute for Health and Care Excellence
(Journal article; Peer reviewed, 2024)Objectives This study investigates factors associated with use of real-world data (RWD) in economic modelling for single technology appraisals (STAs) of cancer drugs by the National Institute for Health and Care Excellence ... -
Natalizumab promotes anti-inflammatory and repair effects in multiple sclerosis
(Journal article; Peer reviewed, 2024)Background Multiple sclerosis is an inflammatory and degenerative disease of the central nervous system leading to demyelination and axonal loss. Relapsing-remitting multiple sclerosis (RRMS) is commonly treated by ... -
Tetrahydrobiopterin (BH<inf>4</inf>) treatment stabilizes tyrosine hydroxylase: Rescue of tyrosine hydroxylase deficiency phenotypes in human neurons and in a knock-in mouse model
(Journal article; Peer reviewed, 2024)Proteostatic regulation of tyrosine hydroxylase (TH), the rate-limiting enzyme in dopamine biosynthesis, is crucial for maintaining proper brain neurotransmitter homeostasis. Variants of the TH gene are associated with ... -
The cytoplasmic tail of myelin protein zero induces morphological changes in lipid membranes
(Journal article; Peer reviewed, 2024)The major myelin protein expressed by the peripheral nervous system Schwann cells is protein zero (P0), which represents 50% of the total protein content in myelin. This 30-kDa integral membrane protein consists of an ... -
Dopamine synthesis and transport: current and novel therapeutics for parkinsonisms
(Journal article; Peer reviewed, 2024)Parkinsonism is the primary type of movement disorder in adults, encompassing a set of clinical symptoms, including rigidity, tremors, dystonia, bradykinesia, and postural instability. These symptoms are primarily caused ... -
N-terminal cysteine acetylation and oxidation patterns may define protein stability
(Journal article; Peer reviewed, 2024)Oxygen homeostasis is maintained in plants and animals by O2-sensing enzymes initiating adaptive responses to low O2 (hypoxia). Recently, the O2-sensitive enzyme ADO was shown to initiate degradation of target proteins ... -
Evolution of fungal tuberculosis necrotizing toxin (TNT) domain-containing enzymes reveals divergent adaptations to enhance NAD cleavage
(Journal article; Peer reviewed, 2024)Tuberculosis necrotizing toxin (TNT) is a protein domain discovered on the outer membrane of Mycobacterium tuberculosis (Mtb), and the fungal pathogen Aspergillus fumigatus. TNT domains have pure NAD(P) hydrolytic activity, ... -
Breaking boundaries: A rare case of glioblastoma with uncommon extraneural metastases: A case report and literature review
(Journal article; Peer reviewed, 2024)Introduction Extraneural metastases (ENM) from glioblastoma (GBM) remain extremely rare with only a scarce number of cases described in the literature. The lack of cases leads to no consensus on the optimal treatment and ... -
A Nanobody-Based Proximity Ligation Assay Detects Constitutive and Stimulus-Regulated Native Arc/Arg3.1 Oligomers in Hippocampal Neuronal Dendrites
(Journal article; Peer reviewed, 2024)Activity-regulated cytoskeleton-associated protein (Arc), the product of an immediate early gene, plays critical roles in synaptic plasticity and memory. Evidence suggests that Arc function is determined by its oligomeric ... -
Biallelic NAA60 variants with impaired n-terminal acetylation capacity cause autosomal recessive primary familial brain calcifications
(Journal article; Peer reviewed, 2024)Primary familial brain calcification (PFBC) is characterized by calcium deposition in the brain, causing progressive movement disorders, psychiatric symptoms, and cognitive decline. PFBC is a heterogeneous disorder currently ... -
Study preferences and exam outcomes in medical education: insights from renal physiology
(Journal article; Peer reviewed, 2024)Background Efficient learning strategies and resource utilization are critical in medical education, especially for complex subjects like renal physiology. This is increasingly important given the rise in chronic renal ... -
Exploring the nutrient composition of various shellfish available in Norway and their role in providing key nutrients
(Journal article; Peer reviewed, 2024)Shellfish constitute a diverse group of aquatic animals, encompassing numerous species of molluscs and crustaceans able to supply important nutrients beneficial to human health. However, information regarding their nutritional ... -
Distinct Longitudinal Brain White Matter Microstructure Changes and Associated Polygenic Risk of Common Psychiatric Disorders and Alzheimer's Disease in the UK Biobank
(Journal article; Peer reviewed, 2024)Background: During the course of adulthood and aging, white matter (WM) structure and organization are characterized by slow degradation processes such as demyelination and shrinkage. An acceleration of such aging processes ... -
ELF5: A Molecular Clock for Breast Aging and Cancer Susceptibility
(Journal article; Peer reviewed, 2024)Breast cancer is predominantly an age-related disease, with aging serving as the most significant risk factor, compounded by germline mutations in high-risk genes like BRCA1/2. Aging induces architectural changes in breast ... -
Exploring phenotypic heterogeneity of fibronectin binding proteins in Isogenic populations of Staphylococcus aureus
(Master thesis, 2024-09-30)Infectious diseases are a major global health threat, and the primary cause of child mortality in the world. Particularly concerning is the increasing number of antibiotic-resistant bacteria, listed as one of WHOs 10 biggest ... -
Overlay databank unlocks data-driven analyses of biomolecules for all
(Journal article; Peer reviewed, 2024)Tools based on artificial intelligence (AI) are currently revolutionising many fields, yet their applications are often limited by the lack of suitable training data in programmatically accessible format. Here we propose ... -
GWAS meta-analysis reveals key risk loci in essential tremor pathogenesis
(Journal article; Peer reviewed, 2024)Essential tremor (ET) is a prevalent neurological disorder with a largely unknown underlying biology. In this genome-wide association study meta-analysis, comprising 16,480 ET cases and 1,936,173 controls from seven datasets, ...
RSS 2.0