• Generation of an enhancer-driven gene expression viral tool specific to dentate granule cell-types through direct hippocampal injection 

  Potenza, Maria Letizia; Blankvoort, Stefan Matthias Adriaan; Carvalho, Miguel; Grimstvedt, Joachim Schweder; Di Maria, Valentina; Moan, Kristian Magnus; Raveendran Nair, Rajeevkumar; Flatset, Marcus Sandbukt; Zhang, Qiangwei; Thomas, Laurent Francois; Pauzin, Francois Philippe; Da Silva Mazzarini Baldinotti, Rodolfo; Quattrocolo, Giulia; Bramham, Clive Raymond Evjen; Sætrom, Pål; Witter, Menno Peter; Kentros, Clifford George (Journal article; Peer reviewed, 2024)

  Accurate investigations of neural circuitry require specific genetic access to individual circuit elements, i.e., the myriad neuronal cell-types in the brain. However, native promoters cannot achieve this because while ...

• Brain asymmetries from mid- to late life and hemispheric brain age 

  Korbmacher, Max; van der Meer, Dennis; Beck, Dani; Lange, Ann-Marie Glasø de; Eikefjord, Eli Nina Hølleland; Lundervold, Arvid; Andreassen, Ole; Westlye, Lars Tjelta; Maximov, Ivan (Journal article; Peer reviewed, 2024)

  The human brain demonstrates structural and functional asymmetries which have implications for ageing and mental and neurological disease development. We used a set of magnetic resonance imaging (MRI) metrics derived from ...

• Naa80 is required for actin N-terminal acetylation and normal hearing in zebrafish 

  Ree, Rasmus; Lin, Sheng-Jia; Dahl, Lars Ole Sti; Huang, Kevin; Petree, Cassidy; Varshney, Gaurav; Arnesen, Thomas (Journal article; Peer reviewed, 2024)

  Actin is a critical component of the eukaryotic cytoskeleton. In animals, actins undergo unique N-terminal processing by dedicated enzymes resulting in mature acidic and acetylated forms. The final step, N-terminal ...

• Luminal epithelial cells integrate variable responses to aging into stereotypical changes that underlie breast cancer susceptibility 

  Sayaman, Rosalyn W.; Miyano, Masaru; Carlson, Eric G.; Senapati, Parijat; Zirbes, Arrianna; Shalabi, Sundus F.; Todhunter, Michael E.; Seewaldt, Victoria E.; Neuhausen, Susan L.; Stampfer, Martha R.; Schones, Dustin E.; LaBarge, Mark (Journal article; Peer reviewed, 2024)

  Effects from aging in single cells are heterogenous, whereas at the organ- and tissue-levels aging phenotypes tend to appear as stereotypical changes. The mammary epithelium is a bilayer of two major phenotypically and ...

• Large-scale analysis of structural brain asymmetries during neurodevelopment: Associations with age and sex in 4265 children and adolescents 

  Kurth, F.; Schijven, D.; van den Heuvel, Odile A; Hoogman, M.; van Rooij, Rooij; Stein, D.J.; Buitelaar, J.K.; Bölte, S.; Auzias, G.; Kushki, A.; Venkatasubramanian, G.; Rubia, K.; Bollmann, S.; Isaksson, J.; Jaspers-Fayer, F.; Marsh, R.; Batistuzzo, M.C.; Arnold, P.D.; Bressan, R.A.; Stewart, S.E.; Gruner, P.; Sørensen, Lin; Pan, P.M.; Silk, T.J.; Gur, R.C.; Cubillo, A.I.; Haavik, Jan; O'Gorman Tuura, Tuura; Hartman, C.A.; Calvo, R.; McGrath, J.; Calderoni, S.; Jackowski, Andrea Parolin; Chantiluke, K.C.; Satterthwaite, T.D.; Busatto, G.F.; Nigg, J.T.; Gur, R.E.; Retico, A.; Tosetti, M.; Gallagher, L.; Szeszko, P.R.; Neufeld, J.; Ortiz, A.E.; Ghisleni, C.; Lazaro, L.; Hoekstra, P.J.; Anagnostou, E.; Hoekstra, L.; Simpson, B.; Plessen, J.K.; Deruelle, C.; Soreni, N.; James, A.; Narayanaswamy, J.; Reddy, J.Y.; Fitzgerald, J.; Bellgrove, M.A.; Salum, G.A.; Janssen, J.; Muratori, F.; Vila, M.; Giral, M. Garcia; Ameis, S.H.; Bosco, P.; Remnélius, K. Lundin; Huyser, C.; Pariente, J.C.; Jalbrzikowski, M.; Rosa, P.G.; O'Hearn, K.M.; Ehrlich, S.; Mollon, J.; Zugman, A.; Christakou, A.; Arango, C.; Fisher, S.E.; Kong, X.; Franke, B.; Medland, S.E.; Thomopoulos, S.I.; Jahanshad, N.; Glahn, D.C.; Thompson, P.M.; Francks, C.; Luders, E. (Journal article; Peer reviewed, 2024)

  Only a small number of studies have assessed structural differences between the two hemispheres during childhood and adolescence. However, the existing findings lack consistency or are restricted to a particular brain ...

• Dynamics of affect modulation in neurodevelopmental disorders (DynAMoND) – study design of a prospective cohort study 

  Bayas, Maximilian; Kockler, Tobias D.; Ramos-Quiroga, Josep Antoni; Caller, Silvia Muñoz; Fadeuilhe, Christian; de Girolamo, Giovanni; Iozzino, Laura; D’Addazio, Miriam; Haavik, Jan; Halmøy, Anne; Hellum, Karin Schiøler; Kolle, Joakim Njaastad; Osnes, Berge; Lundervold, Astri J.; Perroud, Nader; Hasler, Roland; De Almeida, Mélanie Teixeira; Ebner-Priemer, Ulrich W.; Thanarajah, Sharmili Edwin; Schiweck, Carmen; Matura, Silke; Repple, Jonathan; Reif, Andreas; Aichholzer, Mareike (Journal article; Peer reviewed, 2024)

  Background Attention-deficit/hyperactivity disorder (ADHD) is a common neuro-developmental disorder that often persists into adulthood. Moreover, it is frequently accompanied by bipolar disorder (BD) as well as borderline ...

• Significance of utilizing in silico structural analysis and phenotypic data to characterize phenylalanine hydroxylase variants: A PAH landscape 

  Himmelreich, Nastassja; Ramón-Maiques, Santiago; Navarrete, Rosa; Castejon-Fernandez, Natalia; Garbade, Sven F.; Martinez, Aurora; Desviat, Lourdes R.; Pérez, Belén; Blau, Nenad (Journal article; Peer reviewed, 2024)

  Phenylketonuria (PKU) is a genetic disorder caused by variations in the phenylalanine hydroxylase (PAH) gene. Among the 3369 reported PAH variants, 33.7% are missense alterations. Unfortunately, 30% of these missense ...

• Comparing in vitro cytotoxic drug sensitivity in colon and pancreatic cancer using 2D and 3D cell models: Contrasting viability and growth inhibition in clinically relevant dose and repeated drug cycles 

  Tidwell, Tia; Røsland, Gro Vatne; Tronstad, Karl Johan; Søreide, Kjetil; Hagland, Hanne Røland (Journal article; Peer reviewed, 2024)

  Background In vitro drug screening that is more translatable to the in vivo tumor environment can reduce both time and cost of cancer drug development. Here we address some of the shortcomings in screening and show how ...

• Assessing N-terminal acetylation status of cellular proteins via an antibody specific for acetylated methionine 

  Larsen, Silje Kathrine; Bekkelund, Åse Karine; Glomnes, Nina; Arnesen, Thomas; Aksnes, Henriette (Journal article; Peer reviewed, 2024)

  N-terminal acetylation is being recognized as a factor affecting protein lifetime and proteostasis. It is a modification where an acetyl group is added to the N-terminus of proteins, and this occurs in 80 % of the human ...

• In vivo turnover and biodistribution of soluble AXL: implications for biomarker development 

  Tenstad, Olav; Christakou, Eleni; Hodneland Nilsson, Linn; Gausdal, Gro; Micklem, David Robert; Kursula, Petri Tapani; Lorens, James; Reed, Rolf Kåre (Journal article; Peer reviewed, 2024)

  Soluble biomarkers are paramount to personalized medicine. However, the in vivo turnover and biodistribution of soluble proteins is seldom characterized. The cleaved extracellular domain of the AXL receptor (sAXL) is a ...

• Review of metastasis to meningiomas with case examples 

  Sættem, Magnus Fagerheim; Sundstrøm, Terje; Sæle, Anna Kristine Myrmel; Mahesparan, Rupavathana (Journal article; Peer reviewed, 2024)

  Introduction A tumor-to-tumor metastasis (TTM) is a rare metastatic process where a primary malignant tumor metastasizes to another tumor, most commonly a benign tumor such as a meningioma. Here, we present two recent ...

• Molecular landscape of the overlap between Alzheimer’s disease and somatic insulin-related diseases 

  Ruisch, I. Hyun; Widomska, Joanna; De Witte, Ward; Mota, Nina R.; Fanelli, Giuseppe; Van Gils, Veerle; Jansen, Willemijn J.; Vos, Stephanie J. B.; Fóthi, Abel; Barta, Csaba; Berkel, Simone; Alam, Kazi Asraful; Martinez, Aurora; Haavik, Jan; O’Leary, Aet; Slattery, David; Sullivan, Mairéad; Glennon, Jeffrey; Buitelaar, Jan K.; Bralten, Janita; Franke, Barbara; Poelmans, Geert (Journal article; Peer reviewed, 2024)

  Alzheimer’s disease (AD) is a multifactorial disease with both genetic and environmental factors contributing to its etiology. Previous evidence has implicated disturbed insulin signaling as a key mechanism that plays a ...

• Dynamic changes in immune cell populations by AXL kinase targeting diminish liver inflammation and fibrosis in experimental MASH 

  Grøndal, Sturla Magnus; Tutusaus, Anna; Boix, Loreto; Reig, Maria; Blø, Magnus; Hodneland, Linn I.; Gausdal, Gro; Jackson, Akil; Garcia de Frutos, Pablo; Lorens, James; Morales, Albert; Marí, Montserrat (Journal article; Peer reviewed, 2024)

  Background and aims: Metabolic dysfunction-associated steatohepatitis (MASH) is a significant health concern with limited treatment options. AXL, a receptor tyrosine kinase activated by the GAS6 ligand, promotes MASH through ...

• Molecular mechanism of HNF-1A–mediated HNF4A gene regulation and promoter-driven HNF4A-MODY diabetes 

  Kind, Laura; Molnes, Janne; Tjora, Erling; Raasakka, Arne; Myllykoski, Matti Aukusti; Colclough, Kevin; Saint-Martin, Cécile; Adelfalk, Caroline; Dusatkova, Petra; Pruhova, Stepanka; Valtonen-André, Camilla; Bellanné-Chantelot, Christine; Arnesen, Thomas; Kursula, Petri Tapani; Njølstad, Pål Rasmus (Journal article; Peer reviewed, 2024)

  Monogenic diabetes is a gateway to precision medicine through molecular mechanistic insight. Hepatocyte nuclear factor 1A (HNF-1A) and HNF-4A are transcription factors that engage in crossregulatory gene transcription ...

• Disturbance in cerebral blood microcirculation and hypoxic-ischemic microenvironment are associated with the development of brain metastasis 

  Roesler, Jenny; Spitzer, Daniel; Jia, Xiaoxiong; Aasen, Synnøve Nymark; Sommer, Kathleen; Roller, Bastian; Olshausen, Niels; Hebach, Nils R.; Albinger, Nawid; Ullrich, Evelyn; Zhu, Ling; Wang, Fan; MacAs, Jadranka; Forster, Marie-Therese; Steinbach, Joachim P.; Sevenich, Lisa; Devraj, Kavi; Thorsen, Frits; Karreman, Matthia A.; Plate, Karl H.; Reiss, Yvonne; Harter, Patrick N. (Journal article; Peer reviewed, 2024)

  Background Brain metastases (BM) constitute an increasing challenge in oncology due to their impact on neurological function, limited treatment options, and poor prognosis. BM occurs through extravasation of circulating ...

• Tricyclic and tetracyclic antidepressants upregulate VMAT2 activity and rescue disease-causing VMAT2 variants 

  Wang, Xunan; Marmouzi, Ilias; Finnie, Peter S. B.; Bucher, Meghan L.; Yan, Yuanye; Williams, Erin Q.; Støve, Svein Isungset; Lipina, Tatiana V.; Ramsey, Amy J.; Miller, Gary W.; Salahpour, Ali (Journal article; Peer reviewed, 2024)

  Vesicular monoamine transporter 2 (VMAT2) is an essential transporter that regulates brain monoamine transmission and is important for mood, cognition, motor activity, and stress regulation. However, VMAT2 remains underexplored ...

• Emerging insights in senescence: pathways from preclinical models to therapeutic innovations 

  Mansfield, Luke; Ramponi, Valentina; Gupta, Kavya; Stevenson, Thomas Michael James; Mathew, Abraham Binoy; Barinda, Agian Jeffilano; Herbstein, Florencia; Morsli, Samir (Journal article; Peer reviewed, 2024)

  Senescence is a crucial hallmark of ageing and a significant contributor to the pathology of age-related disorders. As committee members of the young International Cell Senescence Association (yICSA), we aim to synthesise ...

• Evaluating possible maternal effect lethality and genetic background effects in Naa10 knockout mice 

  Lyon, Gholson J.; Longo, Joseph; Garcia, Andrew; Inusa, Fatima; Marchi, Elaine; Shi, Daniel; Dörfel, Max; Arnesen, Thomas; Aldabe, Rafael; Lyons, Scott; Nashat, Melissa A.; Bolton, David (Journal article; Peer reviewed, 2024)

  Amino-terminal (Nt-) acetylation (NTA) is a common protein modification, affecting approximately 80% of all human proteins. The human essential X-linked gene, NAA10, encodes for the enzyme NAA10, which is the catalytic ...

• Bridging big data in the ENIGMA consortium to combine non-equivalent cognitive measures 

  Kennedy, Eamonn; Vadlamani, Shashank; Lindsey, Hannah M.; Lei, Pui-Wa; Jo-Pugh, Mary; Thompson, Paul M.; Tate, David F.; Hillary, Frank G.; Dennis, Emily L.; Wilde, Elisabeth A.; Zunta-Soares, Giovana B.; Yatham, Lakshmi N.; Wylie, Glenn R.; Wu, Mon-Ju; Wroblewski, Adrian; Wild, Krista; Westlye, Lars Tjelta; Werden, Emilio; Walker, William C.; Vivash, Lucy; Vilella, Elisabet; Umpierrez, Guillermo; Ulrichsen, Kristine Moe; Turner, Jessica A.; Troyanskaya, Maya; Torres, Ivan; Tone, Erin; Thomopoulos, Sophia I.; Thomas-Odenthal, Florian; Thames, April; Straube, Benjamin; Stein, Frederike; Stasenko, Alena; Španiel, Filip; Spalleta, Gianfranco; Soares, Jair C.; Schmidt, Andre; Sanders, Anne-Marthe; Salvador, Raymond; Ryan, Nicholas P.; Rowland, Jared; Rootes-Murdy, Kelly; Rodriguez, Mabel; Rodriguez, Jonathan; Richard, Geneviève; Repple, Jonathan; Pomarol-Clotet, Edith; Piras, Federica; Piras, Fabrizio; Parent, Marise; Pardoe, Heath; Ozmen, Mustafa; de la Foz, Victor Ortiz García; Olsen, Alexander; Ollinger, John; Oertel, Viola; O’Brien, Terence; Nunes, Abraham; Newsome, Mary R.; Nenadić, Igor; Myall, Daniel J.; Mwangi, Benson; Morey, Rajendra A.; Michel, Chantal; Merchán-Naranjo, Jessica; Melzer, Tracy R.; Meinert, Susanne; McDonald, Carrie R.; Mayeli, Ahmad; Mattos, Paulo; Marquardt, Craig A.; Marotta, Cassandra; Lundervold, Astri J.; Løvstad, Marianne; Lippa, Sara M.; Liou-Johnson, Victoria; Liebel, Spencer W.; Lengenfelder, Jean; Lee, Jungha; Laskowitz, Sarah; Langella, Roberto; Kwon, Jun Soo; Kumari, Veena; Kuhn, Taylor; Kremen, William S.; Krch, Denise; Kolskår, Knut-Kristian; Knížková, Karolina; Kircher, Tilo; Kindler, Jochen; Kim, Minah; Khlif, Mohamed Salah; Kenney, Kimbra; Kang, Xiaojian; Kaess, Michael; Jansen, Andreas; Irimia, Andrei; Hubl, Daniela; Hoskinson, Kristen R.; Hinkin, Charles; Haavik, Jan; Ha, Minji; Gutierrez-Zotes, Alfonso; Gruber, Marius; Grotegerd, Dominik; Goltermann, Janik; Giza, Christopher C.; Genova, Helen; Fuentes-Claramonte, Paola; Franz, Carol; Frank, Lea E.; Ferrarelli, Fabio; Esopenko, Carrie; Ehrlich, Stefan; Dobryakova, Ekaterina; Disner, Seth G.; Diaz-Caneja, Covadonga M.; DeLuca, John; Davenport, Nicholas; Darby, David; Dannlowski, Udo; Dams-O’Connor, Kristen; Dalrymple-Alford, John C.; Crespo-Facorro, Benedicto; Cifu, David X.; Chiaravalloti, Nancy D.; Calhoun, Vince D.; Caeyenberghs, Karen; Brosch, Katharina; Brodtmann, Amy; Borgwardt, Stefan; Bird, Laura J.; Banaj, Nerisa; Babikian, Talin; Ayesa-Arriola, Rosa; Avram, Mihai; Asarnow, Robert F.; Arango, Celso; Anderson, Tim J.; Ambrogi, Sonia; Alonso-Lana, Silvia; Alda, Martin; Adamson, Maheen (Journal article; Peer reviewed, 2024)

  Investigators in neuroscience have turned to Big Data to address replication and reliability issues by increasing sample size. These efforts unveil new questions about how to integrate data across distinct sources and ...

• Hypoxic glioma-derived exosomal miR-25-3p promotes macrophage M2 polarization by activating the PI3K-AKT-mTOR signaling pathway 

  Xue, Zhiwei; Liu, Junzhi; Xing, Wenchen; Mu, Feiyu; Wu, Yanzhao; Zhao, Jiangli; Liu, Xuchen; Wang, Donghai; Wang, Jian; Li, Xingang; Wang, Jiwei; Huang, Bin (Journal article; Peer reviewed, 2024)

  Background Exosomes (EXO) play crucial roles in intercellular communication and glioma microenvironment modulation. Tumor-associated macrophages are more likely to become M2-like type macrophages in the immunosuppressive ...

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