• AXL expression reflects tumor-immune cell dynamics impacting outcome in non-small cell lung cancer patients treated with immune checkpoint inhibitor monotherapy 

  Rayford, Austin James; Gärtner, Fabian; Ramnefjell, Maria Paula; Lorens, James; Micklem, David Robert; Aanerud, Marianne; Engelsen, Agnete (Journal article; Peer reviewed, 2024-08-21)

  Introduction: AXL receptor expression is proposed to confer immune-checkpoint inhibitor (ICI)-resistance in non-small cell lung cancer (NSCLC) patients. We sought to interrogate AXL expression in conjunction with mutational ...

• Exploring the nutritional composition of farmed Atlantic salmon (Salmo salar) and various shellfish available in Norway : Implications for nutrition and food composition data 

  Reksten, Amalie Moxness (Doctoral thesis, 2024-12-05)

  Bakgrunn: Sjømat spiller en viktig rolle i verdens matforsyning. Det globale behovet for mat er imidlertid økende, og sjømat blir stadig mer anerkjent som en mangfoldig og god kilde til en rekke ulike næringsstoffer, med ...

• On the hunt for metalloenzyme inhibitors: Investigating the presence of metal-coordinating compounds in screening libraries and chemical spaces 

  Schuck de Azevedo, Bruna; Brenk, Ruth (Journal article; Peer reviewed, 2024)

  Metalloenzymes play vital roles in various biological processes, requiring the search for inhibitors to develop treatment options for diverse diseases. While compound library screening is a conventional approach, the ...

• Expression and purification of human neutrophil proteinase 3 from insect cells and characterization of ligand binding 

  Khorsand, Fahimeh; Haug, Bengt Erik; Kursula, Inari Talvikki; Reuter, Nathalie; Brenk, Ruth (Journal article; Peer reviewed, 2024)

  Neutrophil proteinase 3 (PR3) is an important drug target for inflammatory lung diseases such as chronic obstructive pulmonary disease and cystic fibrosis. Drug discovery efforts targeting PR3 require active enzyme for in ...

• Deliberate self-harm in adolescents screening positive for attention-deficit / hyperactivity disorder: a population-based study 

  Austgulen, Amalie; Posserud, Maj-Britt Rocio; Hysing, Mari; Haavik, Jan; Lundervold, Astri J. (Journal article; Peer reviewed, 2024)

  Background Adolescents with attention-deficit / hyperactivity disorder (ADHD) have an increased risk of self-harm. The risk of self-harm among adolescents who display an elevated level of ADHD symptoms, but without a formal ...

• Dietary selenium and protein composition influence methylmercury toxicity in mice 

  Mellingen, Ragnhild Marie (Doctoral thesis, 2024-11-15)

  Metylkvikksølv (MeHg) er en utberedt kontaminant i naturen som mennesker hovedsakelig blir eksponert for gjennom inntak av fisk. Samtidig inneholder fisk, og mat for øvrig, viktige næringsstoffer som kan påvirke MeHg-metabolisme ...

• Updated protein domain annotation of the PARP protein family sheds new light on biological function 

  Suskiewicz, Marcin J.; Munnur, Deeksha; Strømland, Øyvind; Yang, Ji-Chun; Easton, Laura E.; Chatrin, Chatrin; Zhu, Kang; Baretić, Domagoj; Goffinont, Stéphane; Schuller, Marion; Wu, Wing-Fung; Elkins, Jonathan M.; Ahel, Dragana; Sanyal, Sumana; Neuhaus, David; Ahel, Ivan (Journal article; Peer reviewed, 2023)

  AlphaFold2 and related computational tools have greatly aided studies of structural biology through their ability to accurately predict protein structures. In the present work, we explored AF2 structural models of the 17 ...

• Fatigue in Parkinson's Disease: A Proteomic Study of Cerebrospinal Fluid 

  Eidem, Live Egeland; Birkeland, Even; Austdal, Marie; Bårdsen, Kjetil; Lange, Johannes; Alves, Guido Werner; Berven, Frode Steingrimsen; Nilsen, Mari Mæland; Herlofson, Karen; Tysnes, Ole-Bjørn; Omdal, Roald (Journal article; Peer reviewed, 2024)

• Structure-based design of 1-deoxy-D-xylulose 5-phosphate reductoisomerase ligands 

  Schuck de Azevedo, Bruna (Doctoral thesis, 2024-08-29)

  The widespread use of antibiotics has undoubtedly saved countless lives over the last century. However, their indiscriminate use has contributed to the emergence of antimicrobial resistance (AMR), posing a significant ...

• Structural characterization of two nanobodies targeting the ligand-binding pocket of human Arc 

  Godoy Munoz, Jose Miguel; Neset, Lasse; Markusson, Sigurbjörn; Weber, Sarah; Krokengen, Oda Caspara; Sutinen, Aleksi; Christakou, Eleni; Lopez, Andrea J.; Bramham, Clive Raymond Evjen; Kursula, Petri Tapani (Journal article; Peer reviewed, 2024)

  The activity-regulated cytoskeleton-associated protein (Arc) is a complex regulator of synaptic plasticity in glutamatergic neurons. Understanding its molecular function is key to elucidate the neurobiology of memory and ...

• Maternal Fiber Intake During Pregnancy and Development of Attention-Deficit/Hyperactivity Disorder Symptoms Across Childhood: The Norwegian Mother, Father, and Child Cohort Study 

  Solberg, Berit Skretting; Kvalvik, Liv Grimstvedt; Instanes, Johanne Telnes; Hartman, Catharina A.; Klungsøyr, Kari; Li, Lin; Larsson, Henrik; Magnus, Per Minor; Njølstad, Pål Rasmus; Johansson, Stefan; Andreassen, Ole; Bakken, Nora Refsum; Bekkhus, Mona; Austerberry, Chloe; Smajlagic, Dinka; Havdahl, Alexandra; Corfield, Elizabeth Claire; Haavik, Jan; Gjestad, Rolf; Zayats, Tetyana (Journal article; Peer reviewed, 2023)

  Background Epidemiological studies suggest that maternal diet quality during pregnancy may influence the risk of neurodevelopmental disorders in offspring. Here, we investigated associations between maternal intake of ...

• Novel tools to investigate Arc protein molecular function in synaptic plasticity 

  Da Silva Mazzarini Baldinotti, Rodolfo (Doctoral thesis, 2024-09-11)

  Synaptisk plastisitet er en korrelasjon for læring og hukommelse i det mammale hjernen, som produserer endringer på et synaptisk nivå i det nevrale nettverket, som kan være av kortvarig eller langvarig art. For langvarige ...

• Three-dimensional nanofibrous sponges with aligned architecture and controlled hierarchy regulate neural stem cell fate for spinal cord regeneration 

  Li, Zhiwei; Qi, Ye; Sun, Lei; Li, Zheng; Chen, Shaojuan; Zhang, Yuqi; Ma, Yuan; Han, Jinming; Wang, Zide; Zhang, Yulin; Geng, Huimin; Huang, Bin; Wang, Jian; Li, Gang; Li, Xingang; Wu, Shaohua; Ni, Shilei (Journal article; Peer reviewed, 2023)

  Background: Spinal cord injury (SCI) induces neuronal death and disrupts the nerve fiber bundles, which leads to severe neurological dysfunction and even permanent paralysis. A strategy combining biomimetic nanomaterial ...

• One ring closer to a closure: the crystal structure of the ES<inf>3</inf> hydroxymethylbilane synthase intermediate 

  Bustad, Helene J.; Sæter, Marthe Christie; Laitaoja, Mikko; Aarsand, Aasne Karine; Martinez, Aurora; Jänis, Janne; Kallio, Juha Pekka (Journal article; Peer reviewed, 2023)

  Hydroxymethylbilane synthase (HMBS), involved in haem biosynthesis, catalyses the head-to-tail coupling of four porphobilinogens (PBGs) via a dipyrromethane (DPM) cofactor. DPM is composed of two PBGs, and a hexapyrrole ...

• Novel Calcium-Binding Motif Stabilizes and Increases the Activity of Aspergillus fumigatus Ecto-NADase 

  Ferrario, Eugenio; Kallio, Juha Pekka; Strømland, Øyvind; Ziegler, Mathias (Journal article; Peer reviewed, 2023)

  Nicotinamide adenine dinucleotide (NAD) is an essential molecule in all kingdoms of life, mediating energy metabolism and cellular signaling. Recently, a new class of highly active fungal surface NADases was discovered. ...

• Roles of extracellular vesicles in glioblastoma: foes, friends and informers 

  Lunavat, Taral; Nieland, Lisa; Vrijmoet, Anne B.; Zargani-Piccardi, Ayrton; Samaha, Youssef; Breyne, Koen; Breakefield, Xandra O. (Journal article; Peer reviewed, 2023)

  Glioblastoma (GB) tumors are one of the most insidious cancers which take over the brain and defy therapy. Over time and in response to treatment the tumor and the brain cells in the tumor microenvironment (TME) undergo ...

• Linking resting state metabolite concentrations in the dorsal anterior cingulate cortex to response inhibition in OCD, a combined fMRI-MRS study 

  de Joode, Niels T.; Thorsen, Anders Lillevik; Vriend, Chris; Pouwels, Petra J.W.; van Balkom, Anton J.L.M.; Hagen, Kristen; Ousdal, Olga Therese; Hansen, Bjarne Kristian Aaslie; Kvale, Gerd; van den Heuvel, Odile A (Journal article; Peer reviewed, 2023)

  Introduction Obsessive-compulsive disorder (OCD) has been associated with abnormal brain activation in regions related to response inhibition, such as the dorsal anterior cingulate cortex (dACC), as well as dysregulation ...

• Conformational analysis of membrane-proximal segments of GDAP1 in a lipidic environment using synchrotron radiation suggests a mode of assembly at the mitochondrial outer membrane 

  Sutinen, Aleksi; Jones, Nykola C.; Hoffmann, Søren Vrønning; Ruskamo, Salla; Kursula, Petri Tapani (Journal article; Peer reviewed, 2023)

  The mitochondrial outer membrane creates a diffusion barrier between the cytosol and the mitochondrial intermembrane space, allowing the exchange of metabolic products, important for efficient mitochondrial function in ...

• Forward genetics and functional analysis highlight Itga11 as a modulator of murine psoriasiform dermatitis 

  Bieber, Katja; Bezdek, Siegfried; Gupta, Yask; Vorobyev, Artem; Sezin, Tanya; Gross, Natalie; Prüssmann, Jasper; Sayegh, Jean-Paul; Becker, Mareike; Mousavi, Sadegh; Hdnah, Ashref; Künzel, Sven; Ibrahim, Saleh M; Ludwig, Ralf J; Gullberg, Elon Donald; Sadik, Christian D (Journal article; Peer reviewed, 2023)

  Psoriasis is a chronic inflammatory skin condition. Repeated epicutaneous application of Aldara® (imiquimod) cream results in psoriasiform dermatitis in mice. The Aldara®-induced psoriasiform dermatitis (AIPD) mouse model ...

• BCL2L13 promotes mitophagy through DNM1L-mediated mitochondrial fission in glioblastoma 

  Wang, Jiwei; Chen, Anbin; Xue, Zhiwei; Liu, Junzhi; He, Ying; Liu, Guowei; Zhao, Zhimin; Li, Wenjie; Zhang, Qing; Chen, Anjing; Wang, Jian; Li, Xingang; Wang, Xinyu; Huang, Bin (Journal article; Peer reviewed, 2023)

  There is an urgent need for novel diagnostic and therapeutic strategies for patients with Glioblastoma multiforme (GBM). Previous studies have shown that BCL2 like 13 (BCL2L13) is a member of the BCL2 family regulating ...

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