• Understanding proteostasis dysregulation in phenylketonuria – a paradigm disease for inborn error of metabolism 

  Prestegård, Karina Skjervheim (Doctoral thesis, 2022-09-06)

  Fenylketonuria (PKU) er en medfødt stoffskiftesykdom forårsaket av mutasjoner i genet for fenylalanin hydroksylase (PAH), og fører til ustabile og ofte feilfoldete enzymer med nedsatt evne til å metabolisere aminosyren ...

• Early Evolutionary Selection of NAD Biosynthesis Pathway in Bacteria 

  Sharma, Suraj; Hsieh, Yin-Chen; Dietze, Jørn; Bockwoldt, Mathias; Strømland, Øyvind; Ziegler, Mathias; Heiland, Ines (Journal article; Peer reviewed, 2022)

  Bacteria use two alternative pathways to synthesize nicotinamide adenine dinucleotide (NAD) from nicotinamide (Nam). A short, two-step route proceeds through nicotinamide mononucleotide (NMN) formation, whereas the other ...

• Anti-PD-L1/TGF-βR fusion protein (SHR-1701) overcomes disrupted lymphocyte recovery-induced resistance to PD-1/PD-L1 inhibitors in lung cancer 

  Cheng, Bo; Ding, Kaikai; Chen, Pengxiang; Ji, Jianxiong; Luo, Tao; Guo, Xiaofan; Qiu, Wei; Ma, Chunhong; Meng, Xue; Wang, Jian; Yu, Jinming; Liu, Yuan (Journal article, 2022)

  Background Second-generation programmed cell death-protein 1/programmed death-ligand 1 (PD-1/PD-L1) inhibitors, such as bintrafusp alfa (M7824), SHR-1701, and YM101, have been developed to simultaneously block PD-1/PD-L1 ...

• Biochemical and biophysical characterisation of HMBS variants associated with acute intermittent porphyria 

  Sæter, Marthe Christie (Master thesis, 2022-06-01)

• AXL targeting restores PD-1 blockade sensitivity of STK11/LKB1 mutant NSCLC through expansion of TCF1+ CD8 T cells 

  Li, Huiyu; Liu, Zhida; Liu, Longchao; Zhang, Hongyi; Han, Chuanhui; Girard, Luc; Park, Hyunsil; Zhang, Anli; Dong, Chunbo; Ye, Jianfeng; Rayford, Austin James; Peyton, Michael; Li, Xiaoguang; Avila, Kimberley; Cao, Xuezhi; Hu, Shuiqing; Alam, Md Maksudul; Akbay, Esra A.; Solis, Luisa M.; Behrens, Carmen; Hernandez-Ruiz, Sharia; Lu, Wei; Wistuba, Ignacio; Heymach, John V.; Chisamore, Michael; Micklem, David Robert; Gabra, Hani; Gausdal, Gro; Lorens, James; Li, Bo; Fu, Yang-Xin; Minna, John D.; Brekken, Rolf A. (Journal article; Peer reviewed, 2022)

  Mutations in STK11/LKB1 in non-small cell lung cancer (NSCLC) are associated with poor patient responses to immune checkpoint blockade (ICB), and introduction of a Stk11/Lkb1 (L) mutation into murine lung adenocarcinomas ...

• Structural and biophysical characterization of transcription factor HNF-1A as a tool to study MODY3 diabetes variants 

  Kind, Laura; Raasakka, Arne; Molnes, Janne; Aukrust, Ingvild; Bjørkhaug, Lise; Njølstad, Pål Rasmus; Kursula, Petri; Arnesen, Thomas (Journal article; Peer reviewed, 2022)

  Hepatocyte nuclear factor 1A (HNF-1A) is a transcription factor expressed in several embryonic and adult tissues, modulating the expression of numerous target genes. Pathogenic variants in the HNF1A gene are known to cause ...

• Mechanical stress shapes the cancer cell response to neddylation inhibition 

  Mittler, Frédérique; Obeïd, Patricia; Haguet, Vincent; Allier, Cédric; Gerbaud, Sophie; Rulina, Anastasiia; Gidrol, Xavier; Balakirev, Maxim Y. (Journal article; Peer reviewed, 2022)

  Background The inhibition of neddylation by the preclinical drug MLN4924 represents a new strategy to combat cancer. However, despite being effective against hematologic malignancies, its success in solid tumors, where ...

• Development and Validation of Arc Nanobodies: New Tools for Probing Arc Dynamics and Function 

  Ishizuka, Yuta; Mergiya, Tadiwos Feyissa; Baldinotti, Rodolfo Da Silva Mazzarini; Xu, Ju; Hallin, Erik Ingmar; Markusson, Sigurbjörn; Kursula, Petri; Bramham, Clive Raymond Evjen (Journal article; Peer reviewed, 2022)

  Activity-regulated cytoskeleton-associated (Arc) protein plays key roles in long-term synaptic plasticity, memory, and cognitive flexibility. However, an integral understanding of Arc mechanisms is lacking. Arc is proposed ...

• Metabolic flux analysis of 3D spheroids reveals significant differences in glucose metabolism from matched 2D cultures of colorectal cancer and pancreatic ductal adenocarcinoma cell lines 

  Tidwell, Tia R.; Røsland, Gro Vatne; Tronstad, Karl Johan; Søreide, Kjetil; Hagland, Hanne Røland (Journal article; Peer reviewed, 2022)

  Background Most in vitro cancer cell experiments have been performed using 2D models. However, 3D spheroid cultures are increasingly favored for being more representative of in vivo tumor conditions. To overcome the ...

• The Final Maturation State of β-actin Involves N-terminal Acetylation by NAA80, not N-terminal Arginylation by ATE1 

  Drazic, Adrian; Timmerman, Evy; Kajan, Ulrike; Marie, Michaël Bruno Eric; Varland, Sylvia; Impens, Francis; Gevaert, Kris; Arnesen, Thomas (Journal article; Peer reviewed, 2022)

  Actin is a hallmark protein of the cytoskeleton in eukaryotic cells, affecting a range of cellular functions. Actin dynamics is regulated through a myriad of actin-binding proteins and post-translational modifications. The ...

• Human organotypic airway and lung organoid cells of bronchiolar and alveolar differentiation are permissive to infection by influenza and SARS-CoV-2 respiratory virus 

  Ekanger, Camilla Tvedt; Zhou, Fan; Bohan, Dana; Lotsberg, Maria Lie; Ramnefjell, Maria; Hoareau, Laurence; Røsland, Gro Vatne; Lu, Ning; Aanerud, Marianne; Gärtner, Fabian; Salminen, Pirjo-Riitta; Bentsen, Mariann; Halvorsen, Thomas; Ræder, Helge; Akslen, Lars Andreas; Langeland, Nina; Brokstad, Rebecca Jane Cox; Maury, Wendy; Stuhr, Linda Elin Birkhaug; Lorens, James; Engelsen, Agnete Svendsen Tenfjord (Journal article; Peer reviewed, 2022)

  The ongoing coronavirus disease 2019 (COVID-19) pandemic has led to the initiation of unprecedented research efforts to understand the pathogenesis mediated by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). ...

• The styryl benzoic acid derivative DC10 potentiates radiotherapy by targeting the xCT-glutathione axis 

  Sarowar, Shahin; Cirillo, Davide; Játiva, Pablo; Nilsen, Mette Hartmark; Otragane, Sarah-Muheha Anni; Heggdal, Jan Ingemann; Selheim, Frode; Ceña, Valentín; Bjørsvik, Hans-René; Enger, Per Øyvind (Journal article; Peer reviewed, 2022)

  Metastatic tumors with moderate radiosensitivity account for most cancer-related deaths, highlighting the limitations of current radiotherapy regimens. The xCT-inhibitor sulfasalazine (SAS) sensitizes cancer cells to ...

• Inhibitory inputs to an inhibitory interneuron: Spontaneous postsynaptic currents and GABA_A receptors of A17 amacrine cells in the rat retina 

  Beltran Matas, Pablo; Castilho, Aurea; Tencer, Barbora; Veruki, Margaret Lin; Hartveit, Espen (Journal article; Peer reviewed, 2022)

  Amacrine cells constitute a large and heterogeneous group of inhibitory interneurons in the retina. The A17 amacrine plays an important role for visual signalling in the rod pathway microcircuit of the mammalian retina. ...

• Biochemical analysis of novel NAA10 variants suggests distinct pathogenic mechanisms involving impaired protein N‑terminal acetylation 

  McTiernan, Nina; Tranebjærg, Lisbeth; Bjørheim, Anna Steensen; Hogue, Jacob S.; Wilson, William G.; Schmidt, Berkley; Boerrigter, Melissa M.; Nybo, Maja L.; Smeland, Marie; Tümer, Zeynep; Arnesen, Thomas (Journal article; Peer reviewed, 2022)

  NAA10 is the catalytic subunit of the N-terminal acetyltransferase complex, NatA, which is responsible for N-terminal acetylation of nearly half the human proteome. Since 2011, at least 21 different NAA10 missense variants ...

• The mosaic of AII amacrine cell bodies in rat retina is indistinguishable from a random distribution 

  Liu, Jian Hao; Peter, David Olukoya; Guttormsen, Maren Sofie Faldalen; Hossain, Md Kaykobad; Gerking, Yola; Veruki, Margaret Lin; Hartveit, Espen (Journal article; Peer reviewed, 2022)

  The vertebrate retina contains a large number of different types of neurons that can be distinguished by their morphological properties. Assuming that no location should be without a contribution from the circuitry and ...

• Digital reconstruction and quantitative morphometric analysis of bipolar cells in live rat retinal slices 

  Fournel, Rémi; Veruki, Margaret Lin; Hartveit, Espen (Journal article; Peer reviewed, 2022)

  Bipolar cells convey signals from photoreceptors in the outer retina to amacrine and ganglion cells in the inner retina. In mammals, there are typically 10–15 types of cone bipolar cells and one type of rod bipolar cell. ...

• Multiple sclerosis and myelin basic protein: insights into protein disorder and disease 

  Martinsen, Vebjørn; Kursula, Petri (Journal article; Peer reviewed, 2022)

  Myelin basic protein (MBP) is an abundant protein in central nervous system (CNS) myelin. MBP has long been studied as a factor in the pathogenesis of the autoimmune neurodegenerative disease multiple sclerosis (MS). MS ...

• Gene-Environment Interactions in Attention-Deficit/Hyperactivity Disorder Symptom Dimensions: The Role of Unhealthy Food Habits 

  Li, Lin; Taylor, Mark J; Bälter, Katarina; xie, tian; Solberg, Berit Skretting; Haavik, Jan; Arias-Vásquez, Alejandro; Hartman, Catharina A; Larsson, Henrik (Journal article; Peer reviewed, 2021)

  Background: Dietary habits were investigated as environmental risk factors for Attention-Deficit/Hyperactivity Disorder (ADHD). However, no previous studies explored the effects of dietary factors on modifying the role of ...

• Crystal and solution structures reveal oligomerization of individual capsid homology domains of Drosophila Arc 

  Hallin, Erik Ingmar; Markusson, Sigurbjörn; Bottger, Lev; Torda, Andrew E.; Bramham, Clive Raymond Evjen; Kursula, Petri (Journal article; Peer reviewed, 2021)

  Synaptic plasticity is vital for brain function and memory formation. One of the key proteins in long-term synaptic plasticity and memory is the activity-regulated cytoskeleton-associated protein (Arc). Mammalian Arc forms ...

• Protocol for derivation of organoids and patient-derived orthotopic xenografts from glioma patient tumors 

  Oudin, Anaïs; Baus, Virginie; Barthelemy, Vanessa; Fabian, Carina; Klein, Eliane; Dieterle, Monika; Wantz, May; Hau, Ann-Christin; Dording, Claire; Bernard, Amandine; Michelucci, Alessandro; Yabo, Yahaya A.; Kanli, Georgia; Keunen, Olivier; Bjerkvig, Rolf; Niclou, Simone Pierrette; Golebiewska, Anna (Journal article; Peer reviewed, 2021)

  Tumor organoids and patient-derived orthotopic xenografts (PDOXs) are some of the most valuable pre-clinical tools in cancer research. In this protocol, we describe efficient derivation of organoids and PDOX models from ...

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