Department of Biomedicine
Recent Submissions
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Structure-based design of 1-deoxy-D-xylulose 5-phosphate reductoisomerase ligands
(Doctoral thesis, 2024-08-29)The widespread use of antibiotics has undoubtedly saved countless lives over the last century. However, their indiscriminate use has contributed to the emergence of antimicrobial resistance (AMR), posing a significant ... -
Structural characterization of two nanobodies targeting the ligand-binding pocket of human Arc
(Journal article; Peer reviewed, 2024)The activity-regulated cytoskeleton-associated protein (Arc) is a complex regulator of synaptic plasticity in glutamatergic neurons. Understanding its molecular function is key to elucidate the neurobiology of memory and ... -
Maternal Fiber Intake During Pregnancy and Development of Attention-Deficit/Hyperactivity Disorder Symptoms Across Childhood: The Norwegian Mother, Father, and Child Cohort Study
(Journal article; Peer reviewed, 2023)Background Epidemiological studies suggest that maternal diet quality during pregnancy may influence the risk of neurodevelopmental disorders in offspring. Here, we investigated associations between maternal intake of ... -
Novel tools to investigate Arc protein molecular function in synaptic plasticity
(Doctoral thesis, 2024-09-11)Synaptisk plastisitet er en korrelasjon for læring og hukommelse i det mammale hjernen, som produserer endringer på et synaptisk nivå i det nevrale nettverket, som kan være av kortvarig eller langvarig art. For langvarige ... -
Three-dimensional nanofibrous sponges with aligned architecture and controlled hierarchy regulate neural stem cell fate for spinal cord regeneration
(Journal article; Peer reviewed, 2023)Background: Spinal cord injury (SCI) induces neuronal death and disrupts the nerve fiber bundles, which leads to severe neurological dysfunction and even permanent paralysis. A strategy combining biomimetic nanomaterial ... -
One ring closer to a closure: the crystal structure of the ES<inf>3</inf> hydroxymethylbilane synthase intermediate
(Journal article; Peer reviewed, 2023)Hydroxymethylbilane synthase (HMBS), involved in haem biosynthesis, catalyses the head-to-tail coupling of four porphobilinogens (PBGs) via a dipyrromethane (DPM) cofactor. DPM is composed of two PBGs, and a hexapyrrole ... -
Novel Calcium-Binding Motif Stabilizes and Increases the Activity of Aspergillus fumigatus Ecto-NADase
(Journal article; Peer reviewed, 2023)Nicotinamide adenine dinucleotide (NAD) is an essential molecule in all kingdoms of life, mediating energy metabolism and cellular signaling. Recently, a new class of highly active fungal surface NADases was discovered. ... -
Roles of extracellular vesicles in glioblastoma: foes, friends and informers
(Journal article; Peer reviewed, 2023)Glioblastoma (GB) tumors are one of the most insidious cancers which take over the brain and defy therapy. Over time and in response to treatment the tumor and the brain cells in the tumor microenvironment (TME) undergo ... -
Linking resting state metabolite concentrations in the dorsal anterior cingulate cortex to response inhibition in OCD, a combined fMRI-MRS study
(Journal article; Peer reviewed, 2023)Introduction Obsessive-compulsive disorder (OCD) has been associated with abnormal brain activation in regions related to response inhibition, such as the dorsal anterior cingulate cortex (dACC), as well as dysregulation ... -
Conformational analysis of membrane-proximal segments of GDAP1 in a lipidic environment using synchrotron radiation suggests a mode of assembly at the mitochondrial outer membrane
(Journal article; Peer reviewed, 2023)The mitochondrial outer membrane creates a diffusion barrier between the cytosol and the mitochondrial intermembrane space, allowing the exchange of metabolic products, important for efficient mitochondrial function in ... -
Forward genetics and functional analysis highlight Itga11 as a modulator of murine psoriasiform dermatitis
(Journal article; Peer reviewed, 2023)Psoriasis is a chronic inflammatory skin condition. Repeated epicutaneous application of Aldara® (imiquimod) cream results in psoriasiform dermatitis in mice. The Aldara®-induced psoriasiform dermatitis (AIPD) mouse model ... -
BCL2L13 promotes mitophagy through DNM1L-mediated mitochondrial fission in glioblastoma
(Journal article; Peer reviewed, 2023)There is an urgent need for novel diagnostic and therapeutic strategies for patients with Glioblastoma multiforme (GBM). Previous studies have shown that BCL2 like 13 (BCL2L13) is a member of the BCL2 family regulating ... -
Subcellular Distribution of BALF2 and the Role of Rab1 in the Formation of Epstein-Barr Virus Cytoplasmic Assembly Compartment and Virion Release
(Journal article; Peer reviewed, 2023)Epstein-Barr virus (EBV) replicates its genome in the nucleus and undergoes tegumentation and envelopment in the cytoplasm. We are interested in how the single-stranded DNA binding protein BALF2, which executes its function ... -
Conserved intramolecular networks in GDAP1 are closely connected to CMT-linked mutations and protein stability
(Journal article; Peer reviewed, 2023)Charcot-Marie-Tooth disease (CMT) is the most common inherited peripheral polyneuropathy in humans, and its subtypes are linked to mutations in dozens of different genes, including the gene coding for ganglioside-induced ... -
The phospholipid transporter PITPNC1 links KRAS to MYC to prevent autophagy in lung and pancreatic cancer
(Journal article; Peer reviewed, 2023)Background The discovery of functionally relevant KRAS effectors in lung and pancreatic ductal adenocarcinoma (LUAD and PDAC) may yield novel molecular targets or mechanisms amenable to inhibition strategies. Phospholipids ... -
Sulfonylpiperazine compounds prevent Plasmodium falciparum invasion of red blood cells through interference with actin-1/profilin dynamics
(Journal article; Peer reviewed, 2023)With emerging resistance to frontline treatments, it is vital that new antimalarial drugs are identified to target Plasmodium falciparum. We have recently described a compound, MMV020291, as a specific inhibitor of red ... -
A Glimpse into Milestones of Insulin Resistance and an Updated Review of Its Management
(Journal article; Peer reviewed, 2023)Insulin is the main metabolic regulator of fuel molecules in the diet, such as carbohydrates, lipids, and proteins. It does so by facilitating glucose influx from the circulation into the liver, adipose tissue, and skeletal ... -
RNA-binding is an ancient trait of the Annexin family
(Journal article; Peer reviewed, 2023)Introduction: The regulation of intracellular functions in mammalian cells involves close coordination of cellular processes. During recent years it has become evident that the sorting, trafficking and distribution of ... -
Multiparametric brain MRI and deep learning models applied to segmentation and prediction in patients with glioma
(Doctoral thesis, 2024-08-28)Avhandlingen undersøker metoder og algoritmer for hjernetumor (gliom) segmenter- ing, med prediksjon av histologisk gradering, og anatomisk profilering fra MR-bilder. En viktig motivasjon for dette arbeidet har vært ... -
Visualizing Arc protein dynamics and localization in the mammalian brain using AAV-mediated in situ gene labeling
(Journal article; Peer reviewed, 2023)The activity-regulated cytoskeleton-associated (Arc) protein is essential for synaptic plasticity and memory formation. The Arc gene, which contains remnants of a structural GAG retrotransposon sequence, produces a protein ...
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