• Generation of a novel mouse strain with fibroblast-specific expression of Cre recombinase 

  Alam, Jahedul; Musiime, Moses; Romaine, Andreas; Sawant, Mugdha; Melleby, Arne Olav; Lu, Ning; Eckes, Beate; Christensen, Geir; Gullberg, Donald (Journal article; Peer reviewed, 2020)

  Cell-specific expression of genes offers the possibility to use their promoters to drive expression of Cre-recombinase, thereby allowing for detailed expression analysis using reporter gene systems, cell lineage tracing, ...

• CREB family transcription factors are major mediators of BDNF transcriptional autoregulation in cortical neurons 

  Esvald, Eli-Eelika; Tuvikene, Jürgen; Sirp, Alex; Patil, Sudarshan; Bramham, Clive R.; Timmusk, Tõnis (Peer reviewed; Journal article, 2020)

  BDNF signaling via its transmembrane receptor TrkB has an important role in neuronal survival, differentiation, and synaptic plasticity. Remarkably, BDNF is capable of modulating its own expression levels in neurons, forming ...

• Development of robust targeted proteomics assays for cerebrospinal fluid biomarkers in multiple sclerosis 

  Guldbrandsen, Astrid; Lereim, Ragnhild Reehorst; Jacobsen, Mari; Garberg, Hilde Kristin; Kroksveen, Ann Cathrine; Barsnes, Harald; Berven, Frode (Journal article; Peer reviewed, 2020)

  Background Verification of cerebrospinal fluid (CSF) biomarkers for multiple sclerosis and other neurological diseases is a major challenge due to a large number of candidates, limited sample material availability, disease ...

• Maternal pre-pregnancy overweight/obesityand the risk of attention-deficit/hyperactivitydisorder in offspring: a systematic review, meta-analysis and quasi-experimental family-based study 

  Li, Lin; Lagerberg, Tyra; Chang, Zheng; Cortese, Samuele; Rosenqvist, Mina A.; Almqvist, Catarina; D'Onofrio, Brian M.; Hegvik, Tor-Arne; Hartman, Catharina A.; Chen, Qi; Larsson, Henrik (Journal article; Peer reviewed, 2020)

  Previous studies are inconclusive concerning the association between maternal pre-pregnancy overweight/obesity and risk of attention-deficit/hyperactivity disorder (ADHD) in offspring. We therefore conducted a systematic ...

• Exploiting the potential of commercial digital holographic microscopy by combining it with 3D matrix cell culture assays 

  Hellesvik, Monica; Øye, Hanne; Aksnes, Henriette (Journal article; Peer reviewed, 2020)

  3D cell culture assays are becoming increasingly popular due to their higher resemblance to tissue environment. These provide an increased complexity compared to the growth on 2D surface and therefore allow studies of ...

• Disulfiram, a ferroptosis inducer, triggers lysosomal membrane permeabilization by up-regulating ROS in glioblastoma 

  Qiu, Chen; Zhang, Xin; Huang, Bin; Wang, Shuai; Zhou, Wenjing; Li, Chao; Li, Xingang; Wang, Jian; Yang, Ning (Journal article; Peer reviewed, 2020)

  Introduction: Disulfiram (DSF), a drug used in the treatment of alcoholism since 1948, has been shown to have antitumor properties in various tumor types possibly due to the induction of a type cell death, ferroptosis, and ...

• N-terminal acetylation of actin by NAA80 is essential for structural integrity of the Golgi apparatus 

  Beigl, Tobias; Hellesvik, Monica; Saraste, Jaakko; Arnesen, Thomas; Aksnes, Henriette (Journal article; Peer reviewed, 2020)

  N-alpha-acetyltransferase 80 (NAA80) was recently demonstrated to acetylate the N-terminus of actin, with NAA80 knockout cells showing actin cytoskeleton-related phenotypes, such as increased formation of membrane protrusions ...

• Metabolic analysis of amino acids and vitamin B6 pathways in lymphoma survivors with cancer related chronic fatigue 

  Fosså, Alexander; Smeland, Knut Bjøro; Fluge, Øystein; Tronstad, Karl Johan; Loge, Jon Håvard; Midtun, Øyvind; Ueland, Per Magne; Kiserud, Cecilie E. (Journal article; Peer reviewed, 2020)

  Chronic cancer-related fatigue (CF) is a common and distressing condition in a subset of cancer survivors and common also after successful treatment of malignant lymphoma. The etiology and pathogenesis of CF is unknown, ...

• Sequential bortezomib and temozolomide treatment promotes immunological responses in glioblastoma patients with positive clinical outcomes: A phase 1B study 

  Rahman, Mohummad Aminur; Brekke, Jorunn; Arnesen, Victoria Smith; Hannisdal, Marianne; Navarro, Andrea Gras; Waha, Andreas; Herfindal, Lars; Rygh, Cecilie Brekke; Bratland, Eirik; Brandal, Petter; Haász, Judit; Oltedal, Leif; Miletic, Hrvoje; Lundervold, Arvid; Lie, Stein Atle; Goplen, Dorota; Chekenya, Martha (Journal article; Peer reviewed, 2020)

  Background Glioblastoma (GBM) is an aggressive malignant brain tumor where median survival is approximately 15 months after best available multimodal treatment. Recurrence is inevitable, largely due to O6 methylguanine ...

• Identification of a Blood-Based Protein Biomarker Panel for Lung Cancer Detection 

  El-Khoury, Victoria; Schritz, Anna; Kim, Sang-Yoon; Lesur, Antoine; Sertamo, Katriina; Bernardin, Francois; Petritis, Konstantinos; Pirrotte, Patrick; Selinsky, Cheryl; Whiteaker, Jeffrey R; Zhang, Haizhen; Kennedy, Jacob J; Lin, Chenwei; Lee, Lik Wee; Yan, Ping; Tran, Nhan L; Inge, Landon J; Chalabi, Khaled; Decker, Georges; Bjerkvig, Rolf; Paulovich, Amanda G; Berchem, Guy; Kim, Yeoun Jin (Journal article; Peer reviewed, 2020)

  Lung cancer is the deadliest cancer worldwide, mainly due to its advanced stage at the time of diagnosis. A non-invasive method for its early detection remains mandatory to improve patients’ survival. Plasma levels of 351 ...

• AXL is a driver of stemness in normal mammary gland and breast cancer 

  Engelsen, Agnete; Wnuk-Lipinska, Katarzyna; Bougnaud, Sébastien; Vatter, Fanny A. Pelissier; Tiron, Crina Elena; Villadsen, René; Miyano, Masaru; Lotsberg, Maria Lie; Madeleine, Noëlly; Panahandeh, Pouda; Dhakal, Sushil; Tan, Tuan Zea; Peters, Stacey D'Mello; Grøndal, Sturla Magnus; Aziz, Sura Mohammed; Nord, Silje; Herfindal, Lars; Stampfer, Martha R.; Sørlie, Therese; Brekken, Rolf A; Straume, Oddbjørn; Halberg, Nils; Gausdal, Gro; Thiery, Jean Paul; Akslen, Lars A.; Petersen, Ole W.; LaBarge, Mark A.; Lorens, James (Journal article; Peer reviewed, 2020)

  The receptor tyrosine kinase AXL is associated with epithelial plasticity in several solid tumors including breast cancer and AXL-targeting agents are currently in clinical trials. We hypothesized that AXL is a driver of ...

• SLC25A51 is a mammalian mitochondrial NAD+ transporter 

  Luongo, Timothy S.; Eller, Jared M.; Lu, Mu-Jie; Niere, Marc; Raith, Fabio; Perry, Caroline; Bornstein, Marc R.; Oliphint, Paul; Wang, Lin; McReynolds, Melanie R.; Migaud, Marie E.; Rabinowitz, Joshua D.; Johnson, F. Brad; Johnsson, Kai; Ziegler, Mathias; Cambronne, Xiaolu A.; Baur, Joseph A. (Journal article; Peer reviewed, 2020)

  Mitochondria require nicotinamide adenine dinucleotide (NAD+) to carry out the fundamental processes that fuel respiration and mediate cellular energy transduction. Mitochondrial NAD+ transporters have been identified in ...

• Dynamic switching between intrinsic and extrinsic mode networks as demands change from passive to active processing 

  Riemer, Frank; Gruner, Eli Renate; Beresniewicz, Justyna; Kazimierczak, Katarzyna Anna; Ersland, Lars; Hugdahl, Kenneth (Journal article; Peer reviewed, 2020-12-08)

  In this study we report on the relationship between default and extrinsic mode networks across alternating brief periods of rest and active task processing. Three different visual tasks were used in a classic fMRI ON–OFF ...

• On the Effect of DCE MRI Slice Thickness and Noise on Estimated Pharmacokinetic Biomarkers – A Simulation Study 

  Jurek, Jakub; Reisæter, Lars Anders Rokne; Kocinski, Marek; Materka, Andrzej (Journal article; Peer reviewed, 2020)

  Simulation of a dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) multiple sclerosis brain dataset is described. The simulated images in the implemented version have 1×1×1mm3 voxel resolution and arbitrary ...

• Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology 

  Golebiewska, Anna; Hau, Ann-Christin; Oudin, Anaïs; Stieber, Daniel; Yabo, Yahaya A.; Baus, Virginie; Barthelemy, Vanessa; Klein, Eliane; Bougnaud, Sébastien; Keunen, Olivier; Wantz, May; Michelucci, Alessandro; Neirinckx, Virginie; Muller, Arnaud; Kaoma, Tony; Nazarov, Petr V.; Azuaje, Francisco; De Falco, Alfonso; Flies, Ben; Richart, Lorraine; Poovathingal, Suresh K; Arns, Thais; Grzyb, Kamil; Mock, Andreas; Herold-Mende, Christel; Steino, Anne; Brown, Dennis; May, Patrick; Miletic, Hrvoje; Malta, Tathiane M.; Noushmehr, Houtan; Kwon, Yong-Jun; Jahn, Winnie; Klink, Barbara; Tanner, Georgette; Stead, Lucy F.; Mittelbronn, Michel; Skupin, Alexander; Hertel, Frank; Bjerkvig, Rolf; Niclou, Simone Pierrette (Journal article; Peer reviewed, 2020)

  Patient-based cancer models are essential tools for studying tumor biology and for the assessment of drug responses in a translational context. We report the establishment a large cohort of unique organoids and patient-derived ...

• AXL Targeting Abrogates Autophagic Flux and Induces Immunogenic Cell Death in Drug-Resistant Cancer Cells 

  Lotsberg, Maria Lie; Wnuk-Lipinska, Katarzyna; Terry, Stéphane; Tan, Tuan Zea; Lu, Ning; Trachsel-Moncho, Laura; Røsland, Gro Vatne; Siraji, Muntequa Ishtiaq; Hellesøy, Monica; Rayford, Austin James; Jacobsen, Kirstine; Ditzel, Henrik J; Vintermyr, Olav Karsten; Bivona, Trever G; Minna, John; Brekken, Rolf A; Baguley, Bruce; Micklem, David; Akslen, Lars A.; Gausdal, Gro; Simonsen, Anne; Thiery, Jean Paul; Chouaib, Salem; Lorens, James; Engelsen, Agnete (Journal article; Peer reviewed, 2020)

  Introduction Acquired cancer therapy resistance evolves under selection pressure of immune surveillance and favors mechanisms that promote drug resistance through cell survival and immune evasion. AXL receptor tyrosine ...

• Consortium neuroscience of attention deficit/hyperactivity disorder and autism spectrum disorder: The ENIGMA adventure 

  Hoogman, Martine; Van Rooij, Daan; Klein, Marieke; Boedhoe, Premika; Ilioska, Iva; Li, Ting; Patel, Yash; Postema, Merel C.; Zhang-James, Yanli; Anagnostou, Evdokia; Arango, Celso; Auzias, Guillaume; Banaschewski, Tobias; Bau, Claiton H.D.; Behrmann, Marlene; Bellgrove, Mark A.; Brandeis, Daniel; Brem, Silvia; Busatto, Geraldo F.; Calderoni, Sara; Calvo, Rosa; Castellanos, Francisco X.; Coghill, David; Conzelmann, Annette; Daly, Eileen; Deruelle, Christine; Dinstein, Ilan; Durston, Sarah; Ecker, Christine; Ehrlich, Stefan; Epstein, Jeffery N.; Fair, Damien A.; Fitzgerald, Jacqueline; Freitag, Christine; Frodl, Thomas; Gallagher, Louise; Grevet, Eugenio H.; Haavik, Jan; Hoekstra, Pieter J.; Janssen, Joost; Karkashadze, George A.; King, Joseph A.; Konrad, Kerstin; Kuntsi, Jonna; Lazaro, Luisa; Lerch, Jason P.; Lesch, Klaus-Peter; Louza, Mario R.; Luna, Beatriz; Mattos, Paulo; McGrath, Jane; Muratori, Filippo; Murphy, Clodagh; Nigg, Joel T.; Oberwelland Weiss, Eileen; O'Gorman Tuura, Ruth L.; O'Hearn, Kirsten; Oosterlaan, Jaap; Parellada, Mara; Pauli, Paul; Plessen, Kerstin von; Ramos-Quiroga, Josep Antoni; Reif, Andreas; Reneman, Liesbeth; Retico, Alessandra; Rosa, Pedro G.; Rubia, Katya; Shaw, Philip; Silk, Tim J.; Tamm, Leanne; Vilarroya, Oscar; Walitza, Susanne; Jahanshad, Neda; Faraone, Stephen V.; Francks, Clyde; van den Heuvel, Odile A.; Paus, Tomáš; Thompson, Paul M.; Buitelaar, Jan; Franke, Barbara (Journal article; Peer reviewed, 2020)

  Neuroimaging has been extensively used to study brain structure and function in individuals with attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) over the past decades. Two of the main ...

• Discovery and biological characterization of a novel scaffold for potent inhibitors of peripheral serotonin synthesis 

  Betari, Nibal; Sahlholm, Kristoffer; Ishizuka, Yuta; Teigen, Knut; Haavik, Jan (Journal article; Peer reviewed, 2020)

  Aim: Tryptophan hydroxylase 1 (TPH1) catalyzes serotonin synthesis in peripheral tissues. Selective TPH1 inhibitors may be useful for treating disorders related to serotonin dysregulation. Results & methodology: Screening ...

• Lipopolysaccharide induces filtrate leakage from renal tubular lumina into the interstitial space via a proximal tubular Toll-like receptor 4–dependent pathway and limits sensitivity to fluid therapy in mice 

  Nakano, Daisuke; Kitada, Kento; Wan, Ningning; Zhang, Yahua; Wiig, Helge; Wararat, Kittikulsuth; Yanagita, Motoko; Lee, Syann; Jia, Lin; Titze, Jens M.; Nishiyama, Akira (Journal article; Peer reviewed, 2019-12-16)

  Sustained oliguria during fluid resuscitation represents a perplexing problem in patients undergoing therapy for septic acute kidney injury. Here, we tested whether lipopolysaccharide induces filtrate leakage from the ...

• Temozolomide-induced rna interactome uncovers novel lncrna regulatory loops in glioblastoma 

  Fritah, Sabrina; Muller, Arnaud; Jiang, Wei; Mitra, Ramkrishna; Sarmini, Mohamad; Dieterle, Monika; Golebiewska, Anna; Ye, Tao; van Dyck, Eric; Herold-Mende, Christel; Zhao, Zhongming; Azuaje, Francisco; Niclou, Simone Pierrette (Journal article; Peer reviewed, 2020-09-10)

  Resistance to chemotherapy by temozolomide (TMZ) is a major cause of glioblastoma (GBM) recurrence. So far, attempts to characterize factors that contribute to TMZ sensitivity have largely focused on protein-coding genes, ...

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