• Lack of collagen XVIII leads to lipodystrophy and perturbs hepatic glucose and lipid homeostasis 

  Petäistö, Tiina; Vicente, David; Mäkelä, Kari A; Finnilä, Mikko A; Miinalainen, Ilkka; Koivunen, Jarkko; Izzi, Valerio; Aikio, Mari; Karppinen, Sanna-Maria; Davarajan, Raman; Thevenot, Jerome; Herzig, Karl-Heinz; Heljasvaara, Ritva Leena; Pihlajaniemi, Taina (Journal article; Peer reviewed, 2020)

  Liver and adipose tissues play important roles in the regulation of systemic glucose and lipid metabolism. Extracellular matrix synthesis and remodelling are significantly altered in these tissues in obesity and type 2 ...

• Cerebrospinal fluid proteome shows disrupted neuronal development in multiple sclerosis 

  Mosleth, Ellen Færgestad; Vedeler, Christian Alexander; Liland, Kristian Hovde; McLeod, Anette; Bringeland, Gerd Haga; Kroondijk, Liesbeth; Berven, Frode Steingrimsen; Lysenko, Artem; Rawlings, Christopher J.; El-Hajj Eid, Karim; Opsahl, Jill Anette; Gjertsen, Bjørn Tore; Myhr, Kjell-Morten; Gavasso, Sonia (Journal article; Peer reviewed, 2021-02-18)

  Despite intensive research, the aetiology of multiple sclerosis (MS) remains unknown. Cerebrospinal fluid proteomics has the potential to reveal mechanisms of MS pathogenesis, but analyses must account for disease ...

• Editorial: Golgi Dynamics in Physiological and Pathological Conditions 

  Prydz, Kristian; Lupashin, Vladimir; Wang, Yanzhuang; Saraste, Jaakko (Journal article; Peer reviewed, 2020-01-29)

• 2D and 3D U-Nets for skull stripping in a large and heterogeneous set of head MRI using fastai 

  Kaliyugarasan, Satheshkumar; Kocinski, Marek; Lundervold, Arvid; Lundervold, Alexander Selvikvåg (Journal article, 2020)

  Skull stripping in brain imaging is the removal of the parts of images corresponding to non-brain tissue. Fast and accurate skull stripping is a crucial step for numerous medical brain imaging applications, e.g. registration, ...

• Ursodeoxycholic Acid Inhibits Glioblastoma Progression via Endoplasmic Reticulum Stress Related Apoptosis and Synergizes with the Proteasome Inhibitor Bortezomib 

  Yao, Zhong; Zhang, Xun; Zhao, Feihu; Wang, Shuai; Chen, Anjing; Huang, Bin; Wang, Jian; Li, Xingang (Journal article; Peer reviewed, 2020)

  Ursodeoxycholic acid (UDCA) has demonstrated cancer suppressive potential in several tumors. Here, we investigated the antitumor potential and biochemical mechanism of UDCA on glioblastoma multiforme (GBM), the deadliest ...

• Glioblastoma organoids: pre-clinical applications and challenges in the context of immunotherapy 

  Klein, Eliane; Hau, Ann-Christin; Oudin, Anaïs; Golebiewska, Anna; Niclou, Simone Pierrette (Journal article; Peer reviewed, 2020-12-08)

  Malignant brain tumors remain uniformly fatal, even with the best-to-date treatment. For Glioblastoma (GBM), the most severe form of brain cancer in adults, the median overall survival is roughly over a year. New therapeutic ...

• NAA10 p.(D10G) and NAA10 p.(L11R) variants hamper formation of the NatA N-terminal acetyltransferase complex 

  Mc Tiernan, Nina; Darbakk, Christine; Ree, Rasmus; Arnesen, Thomas (Journal article; Peer reviewed, 2020)

  The majority of the human proteome is subjected to N-terminal (Nt) acetylation catalysed by N-terminal acetyltransferases (NATs). The NatA complex is composed of two core subunits—the catalytic subunit NAA10 and the ribosomal ...

• TRIM22 activates NF-κB signaling in glioblastoma by accelerating the degradation of IκBα 

  Ji, Jianxiong; Ding, Kaikai; Luo, Tao; Zhang, Xin; Chen, Anjing; Zhang, Di; Li, Gang; Thorsen, Frits; Huang, Bin; Li, Xingang; Wang, Jian (Journal article; Peer reviewed, 2021)

  NF-κB signaling plays a critical role in tumor growth and treatment resistance in GBM as in many other cancers. However, the molecular mechanisms underlying high, constitutive NF-κB activity in GBM remains to be elucidated. ...

• Tumor-Derived Lactic Acid Contributes to the Paucity of Intratumoral ILC2s 

  Wagner, Marek; Ealey, Kafi N; Tetsu, Hiroe; Kiniwa, Tsuyoshi; Motomura, Yasutaka; Moro, Kazuyo; Koyasu, Shigeo (Journal article; Peer reviewed, 2020)

  Group 2 innate lymphoid cells (ILC2s) are abundant in non-lymphoid tissues and increase following infectious and inflammatory insults. In solid tumors, however, ILC2s constitute a relatively small proportion of immune ...

• Efficient and crucial quality control of HAP1 cell ploidy status 

  Beigl, Tobias B.; Kjosås, Ine; Seljeseth, Emilie; Glomnes, Nina; Aksnes, Henriette (Journal article; Peer reviewed, 2020)

  The near-haploid human cell line HAP1 recently became a popular subject for CRISPR/Cas9 editing, since only one allele requires modification. Through the gene-editing service at Horizon Discovery, there are at present more ...

• Integrin Binding Dynamics Modulate Ligand-Specific Mechanosensing in Mammary Gland Fibroblasts 

  Lerche, Martina; Elosegui-Artola, Alberto; Kechagia, Jenny Z.; Guzmán, Camilo; Georgiadou, Maria; Andreu, Ion; Gullberg, Donald; Roca-Cusachs, Pere; Peuhu, Emilia; Ivaska, Johanna (Journal article; Peer reviewed, 2020)

  The link between integrin activity regulation and cellular mechanosensing of tissue rigidity, especially on different extracellular matrix ligands, remains poorly understood. Here, we find that primary mouse mammary gland ...

• Trifluoperazine prolongs the survival of experimental brain metastases by STAT3-dependent lysosome membrane permeabilization 

  Zhang, Xin; Ding, Kaikai; Ji, Jianxiong; Parajuli, Himalaya; Aasen, Synnøve Nymark; Espedal, Heidi; Huang, Bin; Chen, Anjing; Wang, Jian; Li, Xingang; Thorsen, Frits (Journal article; Peer reviewed, 2020)

  Brain metastasis is a major cause of mortality in melanoma patients. The blood-brain barrier (BBB) prevents most anti-tumor compounds from entering the brain, which significantly limits their use in the treatment of brain ...

• Novel clearance of muscle proteins by muscle cells 

  Muslimovic, Aida; Friden, Vincent; Starnberg, Karin; Tenstad, Olav; Espedal, Heidi; Vukusic, Kristina; Nyström, Susanne; Wesén, Emelie; Esbjörner, Elin K; Granholm, Kristoffer; Lindahl, Bertil; Hammarsten, Ola (Journal article; Peer reviewed, 2020)

  Blood levels of cardiac troponins (cTn) and myoglobin are analysed when myocardial infarction (MI) is suspected. Here we describe a novel clearance mechanism for muscle proteins by muscle cells. The complete plasma clearance ...

• Cryo-EM, X-ray diffraction, and atomistic simulations reveal determinants for the formation of a supramolecular myelin-like proteolipid lattice 

  Ruskamo, Salla; Krokengen, Oda Caspara; Kowal, Julia; Nieminen, Tuomo; Lehtimäki, Mari; Raasakka, Arne; Dandey, Venkata P; Vattulainen, Ilpo; Stahlberg, Henning; Kursula, Petri (Journal article; Peer reviewed, 2020)

  Myelin protein P2 is a peripheral membrane protein of the fatty acid–binding protein family that functions in the formation and maintenance of the peripheral nerve myelin sheath. Several P2 gene mutations cause human ...

• Bidirectional Dysregulation of AMPA Receptor-Mediated Synaptic Transmission and Plasticity in Brain Disorders 

  Zhang, Hongyu; Bramham, Clive R. (Journal article; Peer reviewed, 2020-07-10)

  AMPA receptors (AMPARs) are glutamate-gated ion channels that mediate the majority of fast excitatory synaptic transmission throughout the brain. Changes in the properties and postsynaptic abundance of AMPARs are pivotal ...

• Biophysical analysis of Plasmodium falciparum Hsp70-Hsp90 organising protein (PfHop) reveals a monomer that is characterised by folded segments connected by flexible linkers 

  Makumire, Stanley; Zininga, Tawanda; Vahokoski, Juha; Kursula, Inari; Shonhai, Addmore (Journal article; Peer reviewed, 2020)

  Plasmodium falciparum causes the most lethal form of malaria. The cooperation of heat shock protein (Hsp) 70 and 90 is thought to facilitate folding of select group of cellular proteins that are crucial for cyto-protection ...

• Crystal and solution structure of NDRG1, a membranebinding protein linked to myelination and tumour suppression 

  Mustonen, Venla; Muruganandam, Gopinath; Loris, Remy; Kursula, Petri; Ruskamo, Salla (Journal article; Peer reviewed, 2021)

  N-myc downstream-regulated gene 1 (NDRG1) is a tumour suppressor involved in vesicular trafficking and stress response. NDRG1 participates in peripheral nerve myelination, and mutations in the NDRG1 gene lead to ...

• Targeting the Class A Carbapenemase GES-5 via Virtual Screening 

  Klein, Raphael; Cendron, Laura; Montanari, Maria; Bellio, Pierangelo; Celenza, Giuseppe; Maso, Lorenzo; Tondi, Donatella; Brenk, Ruth (Journal article; Peer reviewed, 2020)

  The worldwide spread of β-lactamases able to hydrolyze last resort carbapenems contributes to the antibiotic resistance problem and menaces the successful antimicrobial treatment of clinically relevant pathogens. Class A ...

• LncRNAs Predicted to Interfere With the Gene Regulation Activity of miR-637 and miR-196a-5p in GBM 

  Zheng, Jingfang; Su, Zhiying; Kong, Yang; Lin, Qingping; Liu, Hongli; Wang, Yanlong; Wang, Jian (Journal article; Peer reviewed, 2020)

  Rigorous molecular characterization of biological systems has uncovered a variety of gene variations underlying normal and disease states and a remarkable complexity in the forms of RNA transcripts that exist. A recent ...

• Phosphoglycerate Mutase 1 Activates DNA Damage Repair via Regulation of WIP1 Activity 

  Ohba, Shigeo; Johannessen, Tor-Christian Aase; Chatla, Kamalakar; Yang, Xiaodong; Pieper, Russell O.; Mukherjee, Joydeep (Journal article; Peer reviewed, 2020)

  The metabolic enzyme phosphoglycerate mutase 1 (PGAM1) is overexpressed in several types of cancer, suggesting an additional function beyond its established role in the glycolytic pathway. We here report that PGAM1 is ...

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