• The 14-3-3 proteins in regulation of cellular metabolism 

      Kleppe, Rune; Martinez, Aurora; Døskeland, Stein Ove; Haavik, Jan (Peer reviewed; Journal article, 2011-09)
      Thirty years ago, it was discovered that 14-3-3 proteins could activate enzymes involved in amino acid metabolism. In the following decades, 14-3-3s have been shown to be involved in many different signaling pathways that ...
    • Abrogation of Anthracycline and Ischemia-Reperfusion Induced Injury by Cell Signaling Modulators 

      Wergeland, Anita (Doctoral thesis; Peer reviewed, 2013-10-18)
      Chemotherapy has a long history in cancer treatment, and the anthracycline used in Paper I and II are among the most effective anti-cancer drugs developed. Unfortunately, the use of anthracyclines is dose-restricted due ...
    • An accessible proteogenomics informatics resource for cancer researchers 

      Chambers, Matthew C.; Jagtap, Pratik D.; Johnson, James E.; McGowan, Thomas; Kumar, Praveen; Onsongo, Getiria; Guerrero, Candace R.; Barsnes, Harald; Vaudel, Marc; Martens, Lennart; Grüning, Björn; Cooke, Ira R.; Heydarian, Mohammad; Reddy, Karen L.; Griffin, Timothy J. (Peer reviewed; Journal article, 2017)
      Proteogenomics has emerged as a valuable approach in cancer research, which integrates genomic and transcriptomic data with mass spectrometry–based proteomics data to directly identify expressed, variant protein sequences ...
    • Actin Post-translational Modifications: The Cinderella of Cytoskeletal Control 

      Varland, Sylvia; Vandekerckhove, Joel; Drazic, Adrian (Peer reviewed; Journal article, 2019)
      Actin is one of the most abundant proteins in eukaryotic cells and the main component of the microfilament system. It plays essential roles in numerous cellular activities including muscle contraction, maintenance of cell ...
    • Activated NK cells are potent effectors against glioblastoma cells due to activating KIR2DS2 and KIR2DS4 - HLA ligand interactions - In vitro study 

      Gras Navarro, Andrea (Master thesis, 2013-06-03)
      Background: Glioblastoma (GBM) is the most malignant brain tumor, where patients' median survival is only 14,6 months after diagnosis, thus novel, effective adjuvant therapies are required. Natural Killer (NK) cells are ...
    • Activation of Protein Kinase A and Exchange Protein Directly Activated by cAMP Promotes Adipocyte Differentiation of Human Mesenchymal Stem Cells 

      Jia, Bingbing; Madsen, Lise; Petersen, Rasmus Koefoed; Techer, Nathalie; Kopperud, Reidun Kristin; Ma, Tao; Døskeland, Stein Ove; Ailhaud, Gérard; Wang, Jinfu; Amri, Ez-Zoubir; Kristiansen, Karsten (Peer reviewed; Journal article, 2012-03-27)
      Human mesenchymal stem cells are primary multipotent cells capable of differentiating into several cell types including adipocytes when cultured under defined in vitro conditions. In the present study we investigated the ...
    • Adult ADHD and Comorbid Somatic Disease: A Systematic Literature Review 

      Instanes, Johanne Telnes; Klungsøyr, Kari; Halmøy, Anne; Fasmer, Ole Bernt; Haavik, Jan (Peer reviewed; Journal article, 2016)
      Objective: To systematically review, synthesize, and appraise available evidence, connecting adult ADHD (aADHD) with somatic disease. Method: Embase, Psychinfo, and Medline databases were searched for studies published ...
    • Age-dependent association between protein expression of the embryonic stem cell marker Cripto-1 and survival of glioblastoma patients 

      Tysnes, Berit Bølge; Sætran, Hege Aase; Mørk, Sverre; Margaryan, Naira v.; Eide, Geir Egil; Petersen, Kjell; Strizzi, Luigi; Hendrix, J. C. (Peer reviewed; Journal article, 2013-12)
      Exploring the re-emergence of embryonic signaling pathways may reveal important information for cancer biology. Nodal is a transforming growth factor-β (TGF-β)-related morphogen that plays a critical role during embryonic ...
    • Age-Related Dysfunction in Mechanotransduction Impairs Differentiation of Human Mammary Epithelial Progenitors 

      Pelissier, Fanny; Garbe, James C.; Ananthanarayanan, Badriprasad; Miyano, Masaru; Lin, ChunHan; Jokela, Tiina; Kumar, Sanjay; Stampfer, Martha R.; Lorens, James; LaBarge, Mark A. (Peer reviewed; Journal article, 2014-06-26)
      Dysfunctional progenitor and luminal cells with acquired basal cell properties accumulate during human mammary epithelial aging for reasons not understood. Multipotent progenitors from women aged <30 years were exposed to ...
    • AII amacrine cells: quantitative reconstruction and morphometric analysis of electrophysiologically identified cells in live rat retinal slices imaged with multi-photon excitation microscopy 

      Zandt, Bas-Jan; Liu, Jian Hao; Veruki, Margaret Lin; Hartveit, Espen (Peer reviewed; Journal article, 2016-02)
      AII amacrine cells have been found in all mammalian retinas examined and play an important role for visual processing under both scotopic and photopic conditions. Whereas ultrastructural investigations have provided a ...
    • Altered DNA methylation profile in Norwegian patients with Autoimmune Addison’s Disease 

      Bjånesøy, Trine Elholm; Andreassen, Bettina Kulle; Bratland, Eirik; Reiner, Andrew Henry; Islam, Shahinul; Husebye, Eystein Sverre; Bakke, Marit (Peer reviewed; Journal article, 2014-03-22)
      Autoimmune Addison's Disease (AAD) is an endocrine and immunological disease of uncertain pathogenesis resulting from the immune system's destruction of the hormone producing cells of the adrenal cortex. The underlying ...
    • Altered metabolic landscape in IDH‐mutant gliomas affects phospholipid, energy, and oxidative stress pathways 

      Fack, Fred; Tardito, Saverio; Hochart, Guillaume; Oudin, Anaïs; Zheng, Liang; Fritah, Sabrina; Golebiewska, Anna; Nazarov, Petr; Bernard, Amandine; Hau, Ann-Christin; Keunen, Olivier; Leenders, William P.J.; Lund-Johansen, Morten; Stauber, Jonathan; Gottlieb, Eyal; Bjerkvig, Rolf; Niclou, Simone Pierrette (Peer reviewed; Journal article, 2017)
      Heterozygous mutations in NADP‐dependent isocitrate dehydrogenases (IDH) define the large majority of diffuse gliomas and are associated with hypermethylation of DNA and chromatin. The metabolic dysregulations imposed by ...
    • AMPA receptors at ribbon synapses in the mammalian retina: kinetic models and molecular identity 

      Hartveit, Espen; Zandt, Bas-Jan; Madsen, Eirik; Castilho, Aurea; Mørkve, Svein Harald; Veruki, Margaret Lin (Peer reviewed; Journal article, 2017)
      In chemical synapses, neurotransmitter molecules released from presynaptic vesicles activate populations of postsynaptic receptors that vary in functional properties depending on their subunit composition. Differential ...
    • Amplification of the 20q Chromosomal Arm Occurs Early in Tumorigenic Transformation and May Initiate Cancer 

      Tabach, Yuval; Kogan-Sakin, Ira; Buganim, Yosef; Solomon, Hilla; Goldfinger, Naomi; Hovland, Randi; Ke, Xi-Song; Øyan, Anne Margrete; Kalland, Karl-Henning; Rotter, Varda; Domany, Eytan (Peer reviewed; Journal article, 2011-01-31)
      Duplication of chromosomal arm 20q occurs in prostate, cervical, colon, gastric, bladder, melanoma, pancreas and breast cancer, suggesting that 20q amplification may play a causal role in tumorigenesis. According to an ...
    • Anabaenolysins, Novel Cytolytic Lipopeptides from Benthic Anabaena Cyanobacteria 

      Jokela, Jouni; Oftedal, Linn; Herfindal, Lars; Permi, Perttu; Wahlsten, Matti; Døskeland, Stein Ove; Sivonen, Kaarina (Peer reviewed; Journal article, 2012-07-19)
      Two novel cyclic lipopeptides, anabaenolysin A and anabaenolysin B, were isolated from two benthic cyanobacterial strains of the genus Anabaena. This novel class of cyanobacterial lipopeptides has a general structure of a ...
    • Analyzing the Structure of Pathways and Its Influence on the Interpretation of Biomedical Proteomics Data Sets 

      Burger, Bram; Hernández Sánchez, Luis Francisco; Lereim, Ragnhild Reehorst; Barsnes, Harald; Vaudel, Marc (Peer reviewed; Journal article, 2018)
      Biochemical pathways are commonly used as a reference to conduct functional analysis on biomedical omics data sets, where experimental results are mapped to knowledgebases comprising known molecular interactions collected ...
    • Androgen receptor as potential therapeutic target in metastatic endometrial cancer 

      Tangen, Ingvild Løberg; Onyango, Therese Bredholt; Kopperud, Reidun Kristin; Berg, Anna; Halle, Mari Kyllesø; Øyan, Anne Margrete; Werner, Henrica Maria Johanna; Trovik, Jone; Kalland, Karl-Henning; Salvesen, Helga Birgitte; Krakstad, Camilla (Peer reviewed; Journal article, 2016-06-30)
      Purpose: The expression and involvement of estrogen (ER) and progesterone receptor (PR) is extensively studied in endometrial cancer. Androgen receptor (AR) is a hormone receptor less studied in female cancers, and we here ...
    • Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin 

      Snaidero, Nicolas; Velte, Caroline; Myllykoski, Matti; Raasakka, Arne; Ignatev, Alexander; Werner, Hauke B.; Erwig, Michelle S.; Möbius, Wiebke; Kursula, Petri; Nave, Klaus-Armin; Simons, Mikael (Peer reviewed; Journal article, 2017-01)
      The myelin sheath is a multilamellar plasma membrane extension of highly specialized glial cells laid down in regularly spaced segments along axons. Recent studies indicate that myelin is metabolically active and capable ...
    • Antibodies raised against aldehyde-fixed antigens improve sensitivity for postembedding electron microscopy 

      Hussain, Suleman; Fredriksen, Irene; Ringsevjen, Håvard; Kavalali, Ege T.; Davanger, Svend (Peer reviewed; Journal article, 2019)
      Background: Antibodies are one of the most important tools in biological research. High specificity and sensitivity of antibodies are crucial to obtain reliable results. Tissue fixed with glutaraldehyde (GA) is commonly ...
    • Apicomplexan actin polymerization depends on nucleation 

      Kumpula, Esa-Pekka; Pires, Isa; Lasiwa, Davki; Piirainen, Henni; Bergmann, Ulrich; Vahokoski, Juha; Kursula, Inari (Peer reviewed; Journal article, 2017-09-22)
      Filamentous actin is critical for apicomplexan motility and host cell invasion. Yet, parasite actin filaments are short and unstable. Their kinetic characterization has been hampered by the lack of robust quantitative ...