• Correlating local and systemic tumor-associated inflammation in colon cancer : CRP and the tumor immune microenvironment 

  Køstner, Anne Helene (Doctoral thesis, 2023-12-14)

  Bakgrunn: Markører for systemisk inflammasjon er assosiert med dårlig prognose i en rekke ulike kreft typer, inkludert tykk- og endetarms kreft (CRC). I dette prosjektet fokuseres på betydningen av systemisk tumor-assosiert ...

• Early-onset preeclampsia in the balance of Immunology and Pregnancy: Risk factors, the Role of Allergy, and potential protection by Antihistamine use 

  Sande, Anne Kvie (Doctoral thesis, 2023-12-15)

  Bakgrunn: Preeklampsi er delt inn i en tidlig og en sen variant. Dagens kunnskap om kjente risikofaktorer og deres sammenheng mellom de to variantene av preeklampsi er begrenset. Mål: Vårt overordnede mål var å undersøke ...

• Breast cancer of the young: Exploring age-related breast cancer biology 

  Ingebriktsen, Lise Martine (Doctoral thesis, 2023-11-30)

  Brystkreft er en sykdom som i en økende grad rammer kvinner i Norge og den vestlige verden. Brystkreft blant yngre kvinner er også økende, og dessuten assosiert med mer aggressiv tumor type og verre klinisk utfall sammenlignet ...

• Systems analyses of the Fabry kidney transcriptome and its response to enzyme replacement therapy identified and cross-validated enzyme replacement therapy-resistant targets amenable to drug repurposing 

  Delaleu, Nicolas; Marti, Hans Peter; Strauss, Philipp; Sekulic, Miroslav; Osman, Tarig Al-Hadi; Tøndel, Camilla; Skrunes, Rannveig; Leh, Sabine; Svarstad, Einar; Nowak, Albina; Gaspert, Ariana; Rusu, Elena; Kwee, Ivo; Rinaldi, Andrea; Flatberg, Arnar; Eikrem, Øystein Solberg (Journal article; Peer reviewed, 2023)

  Fabry disease is a rare disorder caused by variations in the alpha-galactosidase gene. To a degree, Fabry disease is manageable via enzyme replacement therapy (ERT). By understanding the molecular basis of Fabry nephropathy ...

• Risk assessment and antibody responses to SARS-CoV-2 in healthcare workers 

  Bansal, Amit; Trieu, Mai Chi; Mohn, Kristin Greve-Isdahl; Madsen, Anders; Olofsson, Jan Stefan; Sandnes, Helene Heitmann; Sævik, Marianne; Søyland, Hanne; Hansen, Lena; Onyango, Therese Bredholt; Tøndel, Camilla; Brokstad, Karl Albert; Syre, Heidi; Riis, Åse Garløv; Langeland, Nina; Cox, Rebecca Jane (Journal article; Peer reviewed, 2023)

  Background: Preventing infection in healthcare workers (HCWs) is crucial for protecting healthcare systems during the COVID-19 pandemic. Here, we investigated the seroepidemiology of SARS-CoV-2 in HCWs in Norway with ...

• Differences in white blood cell proportions between schizophrenia cases and controls are influenced by medication and variations in time of day 

  Villar, Jonelle Marie Dickow; Stavrum, Anne-Kristin Støbakk; Nery Spindola, Leticia Maria; Torsvik, Anja; Bjella, Thomas; Steen, Nils Eiel; Djurovic, Srdjan; Andreassen, Ole; Steen, Vidar Martin; Hellard, Stephanie Francoise Claire Le (Journal article; Peer reviewed, 2023)

  Cases with schizophrenia (SCZ) and healthy controls show differences in white blood cell (WBC) counts and blood inflammation markers. Here, we investigate whether time of blood draw and treatment with psychiatric medications ...

• Kvinners erfaringer med abortnemnder 

  Haaland, Marte E. S.; Kjelsvik, Marianne; Cetin, Kaya; Gjengedal, Eva; Moland, Karen Marie; Daltveit, Anne Kjersti; Bruvik, Frøydis (Research report, 2023)

• Primary sclerosing cholangitis: Surrogate markers of natural history, disease severity, and prognosis 

  Fossdal, Guri (Doctoral thesis, 2023-12-01)

  Sammendrag Bakgrunn: Primær skleroserende kolangitt (PSC) er en immunrelatert leversykdom av ukjent årsak som karakteriseres av kolestase, inflammasjon og strikturer i galletreet og vanligvis utvikler seg til generell ...

• Patient-reported outcome and fracture-related infection after ankle fracture surgery 

  Pilskog, Kristian (Doctoral thesis, 2023-12-01)

  Ankelbrudd er det tredje mest vanlige bruddet som opereres etter håndleddsbrudd og hoftebrudd. Disse bruddene utgjør 10% av alle brudd. Operativ behandling er ofte nødvendig for å hindre utvikling av stivhet, smerte og ...

• Functional and Prognostic Role of MicroRNAs in Cancer Associated Fibroblasts and Stroma in Oral Squamous Cell Carcinoma 

  Rajthala, Saroj (Doctoral thesis, 2023-11-23)

  Nyere studier har vist at forandringer i bindevevscellene som omgir kreftsvulsten er viktige for utviklingen av munnhulekreft. Kreft stroma kan regulere fenotypen av kreftcellene, og på den måten kan påvirke klinisk forløpet ...

• Congener-specific accumulation of persistent organic pollutants in marine fish from the Northeast Atlantic Ocean 

  Ho, Quang Tri; Frantzen, Sylvia; Nilsen, Bente Merete; Nøstbakken, Ole Jakob; Mahjour Azad, Atabak; Duinker, Arne; Madsen, Lise; Bank, Michael (Journal article; Peer reviewed, 2023)

  Bioaccumulation of persistent organic pollutants (POPs) in marine fish may pose a health risk to human consumers. Using data from ∼8400 individuals of 15 fish species collected in the North-East Atlantic Ocean (NEAO), we ...

• Comparative effectiveness of Anti-IL5 and Anti-IgE biologic classes in patients with severe asthma eligible for both 

  Pfeffer, Paul E.; Ali, Nasloon; Murray, Ruth; Ulrik, Charlotte; Tran, Trung N.; Maspero, Jorge; Peters, Matthew; Christoff, George C.; Sadatsafavi, Mohsen; Torres-Duque, Carlos A.; Altraja, Alan; Lehtimäki, Lauri; Papadopoulos, Nikolaos G.; Salvi, Sundeep; Costello, Richard W.; Cushen, Breda; Heffler, Enrico; Iwanaga, Takashi; Al-Ahmad, Mona; Larenas-Linnemann, Désirée; Kuna, Piotr; Fonseca, João A; Al-Lehebi, Riyad; Rhee, Chin Kook; Perez-de-Llano, Luis; Perng Steve, Diahn-Warng; Mahboub, Bassam; Wang, Eileen; Goh, Celine; Lyu, Juntao; Newell, Anthony; Alacqua, Marianna; Belevskiy, Andrey S.; Bhutani, Mohit; Bjermer, Leif Hilding; Bjornsdottir, Unnur; Bourdin, Arnaud; Bulow, Anna von; Busby, John; Canonica, Giorgio Walter; Cosio, Borja G.; Dorscheid, Delbert R.; Muñoz-Esquerre, Mariana; FitzGerald, J. Mark; Gil, Esther Garcia; Gibson, Peter G.; Heaney, Liam G.; Hew, Mark; Hilberg, Ole; Hoyte, Flavia; Jackson, David J.; Koh, Mariko Siyue; Ko, Hsin-Kuo Bruce; Lee, Jae Ha; Lehmann, Sverre; Chaves Loureiro, Cláudia; Lúðvíksdóttir, Dóra; Menzies-Gow, Andrew N.; Mitchell, Patrick; Papaioannou, Andriana I.; Popov, Todor A.; Porsbjerg, Celeste M.; Salameh, Laila; Sirena, Concetta; Taillé, Camille; Taube, Christian; Tohda, Yuji; Wechsler, Michael E.; Price, David B. (Journal article; Peer reviewed, 2023)

  Background: Patients with severe asthma may present with characteristics representing overlapping phenotypes, making them eligible for more than one class of biologic. Our aim was to describe the profile of adult patients ...

• CACNA1D overexpression and voltage-gated calcium channels in prostate cancer during androgen deprivation 

  McKerr, Niamh; Mohd-Sarip, Adone; Dorrian, Hannah; Breen, Conor; A. James, Jacqueline; McQuaid, Stephen; Mills, Ian Geoffrey; McCloskey, Karen D. (Journal article; Peer reviewed, 2023)

  Prostate cancer is often treated by perturbing androgen receptor signalling. CACNA1D, encoding CaV1.3 ion channels is upregulated in prostate cancer. Here we show how hormone therapy affects CACNA1D expression and CaV1.3 ...

• Increased Plasma Levels of Triglyceride-Enriched Lipoproteins Associate with Systemic Inflammation, Lipopolysaccharides, and Gut Dysbiosis in Common Variable Immunodeficiency 

  Macpherson, Magnhild Eide; Skarpengland, Tonje; Hov, Johannes Espolin Roksund; Ranheim, Trine; Vestad, Beate; Dahl, Tuva Børresdatter; Fraz, Mai Sasaki Aanensen; Michelsen, Annika Elisabet; Holven, Kirsten Bjørklund; Fevang, Børre; Berge, Rolf Kristian; Aukrust, Pål; Halvorsen, Bente; Jørgensen, Silje Fjellgård (Journal article; Peer reviewed, 2023)

  Purpose: Triglycerides (TG) and their major transport lipoprotein in the circulation (VLDL) appear to be related to inflammation. Patients with common variable immunodeficiency (CVID) have inflammatory complications ...

• Food hypersensitivity: an examination of factors influencing symptoms and temporal changes in the prevalence of sensitization in an adult sample 

  Lam, Holly C. Y.; Neukirch, Catherine; Janson, Christer; Garcia-Aymerich, Judith; Clausen, Michael; Idrose, N. Sabrina; Demoly, Pascal; Bertelsen, Randi Jacobsen; Ruiz, Lidia C.; Raherison, Chantal; Jarvis, Deborah L. (Journal article; Peer reviewed, 2023)

  Background/Objectives: Food hypersensitivity (FHS) is common, but little is known about the factors associated with severe reactions, age of onset and whether sensitization persists. This study examines the factors associated ...

• Antibody-mediated interferences affecting cardiac troponin assays: recommendations from the IFCC Committee on Clinical Applications of Cardiac Biomarkers 

  Hammarsten, Ola; Warner, Janet V.; Lam, Leo; Kavsak, Peter; Lindahl, Bertil; Aakre, Kristin Moberg; Collinson, Paul; Jaffe, Allan S.; Saenger, Amy K.; Body, Richard; Mills, Nicholas L.; Omland, Torbjørn; Ordonez-Llanos, Jordi; Apple, Fred S. (Journal article; Peer reviewed, 2023)

  The International Federation of Clinical Chemistry Committee on Clinical Applications of Cardiac Biomarkers (IFCC C-CB) provides educational documents to facilitate the interpretation and use of cardiac biomarkers in ...

• Shared genetic architecture between irritable bowel syndrome and psychiatric disorders reveals molecular pathways of the gut-brain axis 

  Woldeyohannes, Markos Tesfaye; Jaholkowski, Piotr Pawel; Hindley, Guy; Shadrin, Alexey; Rahman, Zillur; Bahrami, Shahram; Lin, Aihua; Holen, Børge; Parker, Nadine; Cheng, Weiqiu; Rødevand, Linn; Frei, Oleksandr; Djurovic, Srdjan; Dale, Anders M.; Smeland, Olav Bjerkehagen; O’Connell, Kevin S.; Andreassen, Ole (Journal article; Peer reviewed, 2023-08-01)

  Background: Irritable bowel syndrome (IBS) often co-occurs with psychiatric and gastrointestinal disorders. A recent genome-wide association study (GWAS) identified several genetic risk variants for IBS. However, most of ...

• European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for digestive neuroendocrine carcinoma 

  Sorbye, Halfdan; Grande, Enrique; Pavel, Marianne; Tesselaar, Margot; Fazio, Nicola; Reed, Nicholas Simon; Knigge, Ulrich; Christ, Emanuel; Ambrosini, Valentina; Couvelard, Anne; Tiensuu Janson, Eva (Journal article; Peer reviewed, 2023)

  This ENETS guidance paper, developed by a multidisciplinary working group, provides up-to-date and practical advice on the diagnosis and management of digestive neuroendocrine carcinoma, based on recent developments and ...

• Fueling the flames of colon cancer – does CRP play a direct pro-inflammatory role? 

  Køstner, Anne Helene; Fuglestad, Anniken Jørlo; Georgsen, Jeanette Baehr; Nielsen, Patricia Switten; Christensen, Kristina Bang; Zibrandtsen, Helle; Parner, Erik Thorlund; Rajab, Ibraheem M.; Potempa, Lawrence A.; Steiniche, Torben; Kersten, Christian (Journal article; Peer reviewed, 2023-03-17)

  Background: Systemic inflammation, diagnostically ascribed by measuring serum levels of the acute phase reactant C-reactive protein (CRP), has consistently been correlated with poor outcomes across cancer types. CRP exists ...

• Training of medical students in the use of emergency whole blood collection and transfusion in the framework of a civilian walking blood 

  Apelseth, Torunn Oveland; Kristoffersen, Einar Klæboe; Strandenes, Geir; Hervig, Tor Audun (Journal article; Peer reviewed, 2023)

  Introduction: In this report, we describe a training program in emergency whole blood collection and transfusion for medical students at the University of Bergen. The overall aim of the program is to improve the availability ...

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