Browsing Faculty of Medicine by Title

Now showing items 1-20 of 8352

    • A 10-gene prognostic signature points to LIMCH1 and HLA-DQB1 as important players in aggressive cervical cancer disease 

      Halle, Mari Kyllesø; Sødal, Marte; Forsse, David Erik; Engerud, Hilde Renate; Woie, Kathrine; Lura, Njål Gjærde; Wagner-Larsen, Kari Strøno; Trovik, Jone; Bertelsen, Bjørn; Haldorsen, Ingfrid S.; Ojesina, Akinyemi I.; Krakstad, Camilla (Journal article; Peer reviewed, 2021)
      Background: Advanced cervical cancer carries a particularly poor prognosis, and few treatment options exist. Identification of effective molecular markers is vital to improve the individualisation of treatment. We investigated ...

    • A 12-month randomized controlled trial evaluating erythritol air-polishing versus curette/ultrasonic debridement of mandibular furcations in supportive periodontal therapy 

      Ulvik, Ingvild Marie; Sæthre, Terje; Bunæs, Dagmar Fosså; Lie, Stein Atle; Enersen, Morten; Leknes, Knut Norvald (Journal article; Peer reviewed, 2021)
      Background Due to complex morphology and limited access, the cleaning of the furcation area is extremely challenging. Therefore, novel therapeutic approaches need to be tested to potentially overcome debridement limitations. ...

    • The 14-3-3 proteins in regulation of cellular metabolism 

      Kleppe, Rune; Martinez, Aurora; Døskeland, Stein Ove; Haavik, Jan (Peer reviewed; Journal article, 2011-09)
      Thirty years ago, it was discovered that 14-3-3 proteins could activate enzymes involved in amino acid metabolism. In the following decades, 14-3-3s have been shown to be involved in many different signaling pathways that ...

    • 18-24-month HIV-free survival as measurement of the effectiveness of prevention of mother-to-child transmission in the context of lifelong antiretroviral therapy: Results of a community-based survey 

      Tiam, Appolinaire; Gill, Michelle; Machekano, Rhoderick; Tukei, Vincent; Mokone, Majoalane; Viana, Shannon; Letsie, Mosilinyane; Tsietso, Mots'Oane; Seipati, Irene; Khachane, Cecilia; Nei, Marethabile; Mohai, Florence; Tylleskär, Thorkild; Guay, Laura (Journal article; Peer reviewed, 2020)
      Introduction Population-based HIV-free survival at 18–24 months of age among HIV-exposed infants in high prevalence settings in the era of treatment for all is largely unknown. We conducted a community-based survey to ...

    • An 18-Gene signature for vascular invasion is associated with aggressive features and reduced survival in breast cancer 

      Mannelqvist, Monica; Wik, Elisabeth; Stefansson, Ingunn; Akslen, Lars A. (Peer reviewed; Journal article, 2014-06-06)
      Aims: Vascular invasion by tumor cells is known to be important for cancer progression. By microarray and qPCR analyses, we earlier identified an 18-gene signature associated with vascular involvement in endometrial cancer. ...

    • 1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans 

      Sønderby, Ida Elken; van der Meer, Dennis; Moreau, Clara; Kaufmann, Tobias; Walters, G. Bragi; Ellegaard, Maria; Abdellaoui, Abdel; Ames, David; Amunts, Katrin; Andersson, Micael; Armstrong, Nicola J.; Bernard, Manon; Blackburn, Nicholas B.; Blangero, John; Boomsma, Dorret I.; Brodaty, Henry; Brouwer, Rachel M.; Bülow, Robin; Bøen, Rune; Cahn, Wiepke; Calhoun, Vince D.; Caspers, Svenja; Ching, Christopher R. K.; Cichon, Sven; Ciufolini, Simone; Crespo-Facorro, Benedicto; Curran, Joanne E.; Dale, Anders M.; Dalvie, Shareefa; Dazzan, Paola; de Geus, Eco J. C.; Zubicaray, Greig I. de; Zwarte, Sonja M. C. de; Desrivieres, Sylvane; Doherty, Joanne L.; Donohoe, Gary; Draganski, Bogdan; Ehrlich, Stefan; Eising, Else; Espeseth, Thomas; Fejgin, Kim; Fisher, Simon E.; Fladby, Tormod; Frei, Oleksandr; Frouin, Vincent; Fukunaga, Masaki; Gareau, Thomas; Ge, Tian; Glahn, David C.; Grabe, Hans J.; Groenewold, Nynke A.; Gustafsson, Omar; Haavik, Jan; Haberg, Asta Kristine; Hall, Jeremy; Hashimoto, Ryota; Hehir-Kwa, Jayne Y.; Hibar, Derrek P.; Hillegers, Manon H. J.; Hoffmann, Per; Holleran, Laurena; Holmes, Avram J.; Johansson, Stefan; Jönsson, Erik Gunnar; Hellard, Stephanie Francoise Claire Le; Lundervold, Arvid; Lundervold, Astri J.; Moberget, Torgeir; Nordvik, Jan Egil; Sando, Sigrid Botne; Steen, Vidar Martin; Tamnes, Christian Krog; Agartz, Ingrid; Djurovic, Srdjan; Westlye, Lars Tjelta; Andreassen, Ole; Homuth, Georg; Hottenga, Jouke-Jan; Hulshoff Pol, Hilleke E.; Ikeda, Masashi; Jahanshad, Neda; Jockwitz, Christiane; Jørgensen, Niklas R.; Kikuchi, Masataka; Knowles, Emma E. M.; Kumar, Kuldeep; Leu, Costin; Linden, David E. J.; Liu, Jingyu; Maillard, Anne M.; Martin, Nicholas G.; Martin-Brevet, Sandra; Mather, Karen A.; Mathias, Samuel R.; McMahon, Katie L.; McRae, Allan F.; Medland, Sarah E.; Meyer-Lindenberg, Andreas; Modenato, Claudia; Monereo Sánchez, Jennifer; Morris, Derek W.; Mühleisen, Thomas W.; Murray, Robin M.; Nielsen, Jacob; Nyberg, Lars; Olde Loohuis, Loes M.; Ophoff, Roel A.; Owen, Michael J.; Paus, Tomas; Pausova, Zdenka; Peralta, Juan M.; Pike, G. Bruce; Prieto, Carlos; Quinlan, Erin B.; Reinbold, Céline S.; Reis Marques, Tiago; Rucker, James J. H.; Sachdev, Perminder S.; Schofield, Peter R.; Schork, Andrew J.; Schumann, Gunter; Shin, Jean; Shumskaya, Elena; Silva, Ana I.; Sisodiya, Sanjay M.; Stein, Dan J.; Strike, Lachlan T.; Suzuki, Ikuo K.; Teumer, Alexander; Thalamuthu, Anbupalam; Tordesillas-Gutiérrez, Diana; Uhlmann, Anne; Ulfarsson, Magnus O.; van ‘t Ent, Dennis; van den Bree, Marianne B. M.; Vanderhaeghen, Pierre; Vassos, Evangelos; Wen, Wei; Wittfeld, Katharina; Wright, Margaret J.; Stefansson, Hreinn; Stefansson, Kari; Jacquemont, Sébastien; Thompson, Paul M. (Journal article; Peer reviewed, 2021)
      Low-frequency 1q21.1 distal deletion and duplication copy number variant (CNV) carriers are predisposed to multiple neurodevelopmental disorders, including schizophrenia, autism and intellectual disability. Human carriers ...

    • A 2-Dose AERAS-402 Regimen Boosts CD8+ Polyfunctionality in HIV-Negative, BCG-Vaccinated Recipients 

      Sivakumaran, Dhanasekaran; Blatner, Gretta; Bakken, Rasmus; Hokey, David A.; Ritz, Christian; Jenum, Synne; Grewal, Harleen (Journal article; Peer reviewed, 2021)
      Despite the widespread use of BCG, tuberculosis (TB) remains a global threat. Existing vaccine candidates in clinical trials are designed to replace or boost BCG which does not provide satisfying long-term protection. ...

    • 2.5-fold increased risk of recurrent acute myocardial infarction with familial hypercholesterolemia 

      Svendsen, Karianne; Krogh, Henriette Walaas; Igland, Jannicke; Tell, Grethe S.; Mundal, Liv J.; Holven, Kirsten Bjørklund; Bogsrud, Martin P.; Leren, Trond P.; Retterstøl, Kjetil (Journal article; Peer reviewed, 2021)
      Background and aims A first-time acute myocardial infarction (AMI) is a severe diagnosis that leads to initiation or intensification of lipid-lowering medication to prevent recurrent events. Individuals with familial ...

    • The 2009 influenza pandemic in primary care. Clinical manifestations, attitudes and utilisation of services 

      Simonsen, Kristian Anton (Doctoral thesis, 2015-03-25)
      Background: Primary care plays a major role in the response to a pandemic. The objectives of this thesis were to investigate the outbreak of the 2009 influenza pandemic from a primary care perspective with focus on clinical ...

    • 21-Hydroxylase-Specific CD8+ T Cells in Autoimmune Addison’s Disease Are Restricted by HLA-A2 and HLA-C7 Molecules 

      Hellesen, Alexander; Aslaksen, Sigrid; Breivik, Lars Ertesvåg; Røyrvik, Ellen Christine; Bruserud, Øyvind; Edvardsen, Kine Susann Waade; Brokstad, Karl Albert; Wolff, Anette Susanne Bøe; Husebye, Eystein Sverre; Bratland, Eirik (Journal article; Peer reviewed, 2021)
      Objectives: CD8+ T cells targeting 21-hydroxylase (21OH) are presumed to play a central role in the destruction of adrenocortical cells in autoimmune Addison’s disease (AAD). Earlier reports have suggested two immunodominant ...

    • 24-Month HIV-free survival among HIV-exposed Infants in Lesotho: the PEAWIL cohort study 

      Tukei, Vincent; Machekano, Rhoderick; Gill, Michelle; Tiam, Appolinaire; Mokone, Majoalane; Isavwa, Anthony; Nyabela, Malijane; Mots’oane, Tsietso; Nchephe, Seipati; Letsie, Mosilinyane; Kassaye, Seble G.; Guay, Laura (Journal article; Peer reviewed, 2020)
      Introduction Following the implementation of the provision of lifelong antiretroviral therapy to all HIV-positive pregnant or breastfeeding women for prevention of mother-to-child transmission (PMTCT) of HIV by the Kingdom ...

    • 25-hydroxy-vitamin D concentration is not affected by severe or non-severe pneumonia, or inflammation, in young children 

      Haugen, Johanne; Chandyo, Ram Krishna; Ulak, Manjeswori; Mathisen, Maria; Basnet, Sudha; Brokstad, Karl Albert; Valentiner-Branth, Palle; Shrestha, Prakash S.; Strand, Tor A (Peer reviewed; Journal article, 2017-01-17)
      Poor vitamin D status has been associated with increased risk and severity of respiratory tract infections. Whether or not inflammation and infection affects 25-hydroxy vitamin D (25(OH)D) concentration is controversial ...

    • 25-year results after anterior cruciate ligament reconstruction with the use of a patellar tendon autograft 

      Lindanger, Line (Doctoral thesis, 2022-06-17)
      Background: Only a few studies of ACL reconstruction with >20 years of follow-up exists. It is still a pause in the literature concerning the patient’s further sports participation and long-term subjective and objective ...

    • 2D and 3D U-Nets for skull stripping in a large and heterogeneous set of head MRI using fastai 

      Kaliyugarasan, Satheshkumar; Kocinski, Marek; Lundervold, Arvid; Lundervold, Alexander Selvikvåg (Journal article, 2020)
      Skull stripping in brain imaging is the removal of the parts of images corresponding to non-brain tissue. Fast and accurate skull stripping is a crucial step for numerous medical brain imaging applications, e.g. registration, ...

    • A 3-D post-mortem model provides rationale for complications in gastrointestinal surgery : a post-mortem corrosion-cast model 

      Ignjatovic, Dejan (Doctoral thesis, 2007-06-08)

    • 3D dynamic culture of mesenchymal stem cells under fluid flow : Implications for bone regeneration 

      Yamada, Shuntaro (Doctoral thesis, 2023-10-06)
      Skjebnen og veksten til mesenkymale stamceller (MSC) kan påvirkes av biologiske stimuli. I benvev regnes skjærspenning fra væske forårsaket av interstitiell væskestrøm som den primære mekaniske stimulien på celleplan, som ...

    • 3D Modelling of Brain Metastasis Microenvironment for Evaluation of Tumour-Stromal Interactions 

      Berle, Birgitte Feginn (Master thesis, 2023-06-01)
      Brain metastases (BM) occur when cancer cells from the primary location spread to the brain through the bloodstream. BM affects approximately 20-40 % of cancer patients, with the majority originating from lung, breast, and ...

    • 3D-printed Synthetic Polymer Templates for Bone Tissue Engineering : Bulk Modifications and Osteoconduction Assessment 

      Hassan, Mohamad Nageeb (Doctoral thesis, 2022-10-21)
      Syntetiske polymerbiomaterialer er enkle å bearbeide, biologisk inerte og brukes derfor i en rekke biomedisinske applikasjoner. Forskning har i lang tid fokusert på å øke biologiske aktivitet til slike materialers, og å ...

    • A 4 year prospective longitudinal study of progression of dental erosion associated to lifestyle in 13-14 year-old Swedish adolescents 

      Hasselkvist, Agneta; Johansson, Anders; Johansson, Ann-Katrin Gerd (Peer reviewed; Journal article, 2016-04)
      Objectives To evaluate the progression of dental erosion in 13–14 year-olds after 4 years, and its association with lifestyle and oral health. Methods 227 randomly selected 13–14 year-olds from a Public Dental Clinic, ...

    • 450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy 

      Joubert, Bonnie R.; Håberg, Siri Eldevik; Nilsen, Roy Miodini; Wang, Xuting; Vollset, Stein Emil; Murphy, Susan K; Huang, Zhiqing; Hoyo, Cathrine; Midttun, Øivind; Cupul-Uicab, Lea A; Ueland, Per Magne; Wu, Michael C; Nystad, Wenche; Bell, Douglas A; Peddada, Shyamal D; London, Stephanie J (Peer reviewed; Journal article, 2012-10)
      Background: Epigenetic modifications, such as DNA methylation, due to in utero exposures may play a critical role in early programming for childhood and adult illness. Maternal smoking is a major risk factor for multiple ...